format-version: 1.2
date: 14:03:2024 13:35
auto-generated-by: bio2obo:sgd
data-version: R64-3-1
ontology: sgd
property_value: http://purl.org/dc/elements/1.1/title "Saccharomyces Genome Database" xsd:string
property_value: http://purl.org/dc/elements/1.1/description "The Saccharomyces Genome Database \(SGD\) project collects information and maintains a database of the molecular biology of the yeast Saccharomyces cerevisiae." xsd:string

[Typedef]
id: RO:0002162
name: in taxon

[Term]
id: sgd:S000000001
name: YAL001C
def: "Subunit of RNA polymerase III transcription initiation factor complex; part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of the RNA polymerase III transcription initiation factor complex \(TFIIIC\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN24" EXACT []
synonym: "TFC3" EXACT []
synonym: "TSV115" EXACT []
synonym: "tau 138" EXACT []
synonym: "transcription factor TFIIIC subunit TFC3" EXACT []

[Term]
id: sgd:S000000002
name: YAL002W
def: "Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CORVET complex membrane-binding subunit VPS8" EXACT []
synonym: "FUN15" EXACT []
synonym: "VPL8" EXACT []
synonym: "VPS8" EXACT []
synonym: "VPT8" EXACT []

[Term]
id: sgd:S000000003
name: YAL003W
def: "Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex\, which facilitates binding of aminoacyl-tRNA to the ribosomal A site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EF-1beta" EXACT []
synonym: "EFB1" EXACT []
synonym: "TEF5" EXACT []
synonym: "eEF1Balpha" EXACT []
synonym: "translation elongation factor 1 subunit beta" EXACT []

[Term]
id: sgd:S000000004
name: YAL005C
def: "ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus\, cytoplasm\, and cell wall; 98% identical with paralog Ssa2p\, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast \[URE3\] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family ATPase SSA1" EXACT []
synonym: "SSA1" EXACT []
synonym: "YG100" EXACT []

[Term]
id: sgd:S000000005
name: YAL007C
def: "Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p\, Emp24p\, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog\, ERP4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP2" EXACT []

[Term]
id: sgd:S000000006
name: YAL008W
def: "Mitochondrial protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN14" EXACT []

[Term]
id: sgd:S000000007
name: YAL009W
def: "Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis\, required for normal nuclear envelope morphology\, premeiotic replication\, and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Nem1-Spo7 phosphatase regulatory subunit SPO7" EXACT []
synonym: "SPO7" EXACT []

[Term]
id: sgd:S000000008
name: YAL010C
def: "Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER\, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN37" EXACT []
synonym: "MDM10" EXACT []

[Term]
id: sgd:S000000009
name: YAL011W
def: "Protein of unknown function; component of the SWR1 complex\, which exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWC1" EXACT []
synonym: "SWC3" EXACT []

[Term]
id: sgd:S000000010
name: YAL012W
def: "Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYI1" EXACT []
synonym: "CYS3" EXACT []
synonym: "FUN35" EXACT []
synonym: "STR1" EXACT []
synonym: "cystathionine gamma-lyase CYS3" EXACT []

[Term]
id: sgd:S000000011
name: YAL013W
def: "Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes\, as well as maintenance of telomeres\, mating efficiency\, and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEP1" EXACT []
synonym: "FUN54" EXACT []
synonym: "Rpd3L histone deacetylase complex subunit DEP1" EXACT []

[Term]
id: sgd:S000000012
name: YAL014C
def: "Endosomal SNARE related to mammalian syntaxin 8" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLT2" EXACT []
synonym: "SYN8" EXACT []
synonym: "UIP2" EXACT []
synonym: "syntaxin" EXACT []

[Term]
id: sgd:S000000013
name: YAL015C
def: "DNA N-glycosylase and apurinic/apyrimidinic \(AP\) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog\, NTG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN33" EXACT []
synonym: "NTG1" EXACT []
synonym: "SCR1" EXACT []
synonym: "bifunctional N-glycosylase/AP lyase NTG1" EXACT []
synonym: "ogg2" EXACT []

[Term]
id: sgd:S000000014
name: YAL016W
def: "Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A \(PP2A\) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN32" EXACT []
synonym: "TPD3" EXACT []
synonym: "protein phosphatase 2A structural subunit TPD3" EXACT []

[Term]
id: sgd:S000000015
name: YAL017W
def: "PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog\, PSK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN31" EXACT []
synonym: "PSK1" EXACT []
synonym: "serine/threonine protein kinase PSK1" EXACT []

[Term]
id: sgd:S000000016
name: YAL018C
def: "Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p\, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDS1" EXACT []

[Term]
id: sgd:S000000017
name: YAL019W
def: "Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus\, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres\, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks \(DSBs\) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-dependent ATPase FUN30" EXACT []
synonym: "FUN30" EXACT []

[Term]
id: sgd:S000000018
name: YAL020C
def: "Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex\, Kti11p\, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATS1" EXACT []
synonym: "FUN28" EXACT []
synonym: "KTI13" EXACT []

[Term]
id: sgd:S000000019
name: YAL021C
def: "Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase\, which is involved in mRNA poly\(A\) tail shortening" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4" EXACT []
synonym: "CCR4-NOT core exoribonuclease subunit CCR4" EXACT []
synonym: "FUN27" EXACT []
synonym: "NUT21" EXACT []

[Term]
id: sgd:S000000020
name: YAL022C
def: "High affinity\, broad selectivity\, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside \(NmR\) levels between the cytosol and vacuole\, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter \(ENT\) family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN26" EXACT []
synonym: "nucleoside transmembrane transporter FUN26" EXACT []

[Term]
id: sgd:S000000021
name: YAL023C
def: "Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p\, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog\, PMT3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN25" EXACT []
synonym: "PMT2" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase PMT2" EXACT []

[Term]
id: sgd:S000000022
name: YAL024C
def: "Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTE1" EXACT []
synonym: "MSI2" EXACT []
synonym: "mitotic regulator LTE1" EXACT []

[Term]
id: sgd:S000000023
name: YAL025C
def: "Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK16" EXACT []
synonym: "ribosome biosynthesis protein MAK16" EXACT []

[Term]
id: sgd:S000000024
name: YAL026C
def: "Trans-golgi network aminophospholipid translocase \(flippase\); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation\, endocytosis\, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRS2" EXACT []
synonym: "FUN38" EXACT []
synonym: "SWA3" EXACT []
synonym: "aminophospholipid-translocating P4-type ATPase DRS2" EXACT []

[Term]
id: sgd:S000000025
name: YAL027W
def: "5'- and 3'-flap DNA binding protein; recruits Rad1p-Rad10p to single-strand annealing intermediates with 3' non-homologous tails for removal during double-strand break repair; complexes with Rad1p-Rad10p and stimulates its endonuclease activity; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding protein SAW1" EXACT []
synonym: "SAW1" EXACT []

[Term]
id: sgd:S000000026
name: YAL028W
def: "Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+\, alkaline pH\, or cell wall stress\, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog\, FRT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRT2" EXACT []
synonym: "HPH2" EXACT []

[Term]
id: sgd:S000000027
name: YAL029C
def: "Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport\, including ASH1 mRNA\, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog\, MYO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN22" EXACT []
synonym: "MYO4" EXACT []
synonym: "SHE1" EXACT []
synonym: "myosin 4" EXACT []

[Term]
id: sgd:S000000028
name: YAL030W
def: "Vesicle membrane receptor protein \(v-SNARE\); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog\, SNC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNAP receptor SNC1" EXACT []
synonym: "SNC1" EXACT []

[Term]
id: sgd:S000000029
name: YAL031C
def: "Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN21" EXACT []
synonym: "GIP4" EXACT []
synonym: "protein phosphatase regulator GIP4" EXACT []

[Term]
id: sgd:S000000030
name: YAL032C
def: "Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN20" EXACT []
synonym: "PRP45" EXACT []
synonym: "mRNA splicing protein PRP45" EXACT []

[Term]
id: sgd:S000000031
name: YAL033W
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN53" EXACT []
synonym: "POP5" EXACT []
synonym: "RNA-binding protein POP5" EXACT []

[Term]
id: sgd:S000000032
name: YAL034W-A
def: "Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p \(MIND\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSN3" EXACT []
synonym: "MIND complex subunit MTW1" EXACT []
synonym: "MTW1" EXACT []
synonym: "NSL2" EXACT []

[Term]
id: sgd:S000000033
name: YAL035W
def: "Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN12" EXACT []
synonym: "eIF5B" EXACT []
synonym: "translation initiation factor eIF5B" EXACT []
synonym: "yIF2" EXACT []

[Term]
id: sgd:S000000034
name: YAL036C
def: "Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p\, Ygr250cp\, Gir2p and Yap1p via two-hybrid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN11" EXACT []
synonym: "GTP-binding protein RBG1" EXACT []
synonym: "RBG1" EXACT []

[Term]
id: sgd:S000000035
name: YAL037W
def: "Putative protein of unknown function; YAL037W has a paralog\, YOR342C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000036
name: YAL038W
def: "Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate\, the input for aerobic \(TCA cycle\) or anaerobic \(glucose fermentation\) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog\, PYK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC19" EXACT []
synonym: "PYK1" EXACT []
synonym: "pyruvate kinase CDC19" EXACT []

[Term]
id: sgd:S000000037
name: YAL039C
def: "Cytochrome c heme lyase \(holocytochrome c synthase\); attaches heme to apo-cytochrome c \(Cyc1p or Cyc7p\) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects \(MLS\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCHL" EXACT []
synonym: "CYC3" EXACT []
synonym: "holocytochrome c synthase CYC3" EXACT []

[Term]
id: sgd:S000000038
name: YAL040C
def: "G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins\, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetly-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLN3" EXACT []
synonym: "DAF1" EXACT []
synonym: "FUN10" EXACT []
synonym: "WHI1" EXACT []
synonym: "cyclin CLN3" EXACT []

[Term]
id: sgd:S000000039
name: YAL041W
def: "Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance\, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC24" EXACT []
synonym: "CLS4" EXACT []
synonym: "Rho family guanine nucleotide exchange factor CDC24" EXACT []

[Term]
id: sgd:S000000040
name: YAL042W
def: "Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV46" EXACT []
synonym: "FUN9" EXACT []

[Term]
id: sgd:S000000041
name: YAL043C
def: "Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF\, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN39" EXACT []
synonym: "PTA1" EXACT []
synonym: "RNA-processing protein PTA1" EXACT []

[Term]
id: sgd:S000000042
name: YAL044C
def: "H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5\,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5\,10-methylene-THF" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCV3" EXACT []
synonym: "glycine decarboxylase subunit H" EXACT []

[Term]
id: sgd:S000000043
name: YAL045C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000044
name: YAL046C
def: "Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM1" EXACT []

[Term]
id: sgd:S000000045
name: YAL047C
def: "Component of the cytoplasmic Tub4p \(gamma-tubulin\) complex; binds spindle pole bodies and links them to microtubules; is regulated by Cdc5 kinase; has roles in astral microtubule formation and stabilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB4" EXACT []
synonym: "SPC72" EXACT []
synonym: "gamma-tubulin complex subunit SPC72" EXACT []

[Term]
id: sgd:S000000046
name: YAL048C
def: "Outer mitochondrial membrane GTPase\, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed\, globular\, or grape-like mitochondria; ortholog of metazoan Miro GTPases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERMES complex Ca(2+)-binding regulatory GTPase GEM1" EXACT []
synonym: "GEM1" EXACT []
synonym: "GON1" EXACT []

[Term]
id: sgd:S000000047
name: YAL049C
def: "Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM2" EXACT []
synonym: "protein AIM2" EXACT []

[Term]
id: sgd:S000000048
name: YAL051W
def: "Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p\, which binds to oleate-response elements \(ORE\) in the promoter of genes involved in beta-oxidation of fatty acids\, peroxisome organization and biogenesis\, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog\, PIP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OAF1" EXACT []
synonym: "YAF1" EXACT []
synonym: "oleate-activated transcription factor OAF1" EXACT []

[Term]
id: sgd:S000000049
name: YAL053W
def: "Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog\, YOR365C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAD transporter FLC2" EXACT []
synonym: "FLC2" EXACT []
synonym: "HUF2" EXACT []

[Term]
id: sgd:S000000050
name: YAL054C
def: "Acetyl-coA synthetase isoform; along with Acs2p\, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACS1" EXACT []
synonym: "FUN44" EXACT []
synonym: "acetate--CoA ligase 1" EXACT []

[Term]
id: sgd:S000000051
name: YAL055W
def: "Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX22" EXACT []
synonym: "YAF5" EXACT []
synonym: "ubiquitin-protein transferase activating protein PEX22" EXACT []

[Term]
id: sgd:S000000052
name: YAL056W
def: "Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p\, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog\, GPB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPB2" EXACT []
synonym: "KRH1" EXACT []

[Term]
id: sgd:S000000054
name: YAL058W
def: "Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p\, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNE1" EXACT []
synonym: "FUN48" EXACT []
synonym: "calnexin" EXACT []

[Term]
id: sgd:S000000055
name: YAL059W
def: "Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM1" EXACT []

[Term]
id: sgd:S000000056
name: YAL060W
def: "NAD-dependent \(R\,R\)-butanediol dehydrogenase; catalyzes oxidation of \(R\,R\)-2\,3-butanediol to \(3R\)-acetoin\, oxidation of meso-butanediol to \(3S\)-acetoin\, and reduction of acetoin; enhances use of 2\,3-butanediol as an aerobic carbon source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "(R" EXACT []
synonym: "BDH" EXACT []
synonym: "BDH1" EXACT []
synonym: "R)-butanediol dehydrogenase" EXACT []

[Term]
id: sgd:S000000057
name: YAL061W
def: "Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BDH2" EXACT []
synonym: "putative dehydrogenase BDH2" EXACT []

[Term]
id: sgd:S000000058
name: YAL062W
def: "NADP\(+\)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog\, GDH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN51" EXACT []
synonym: "GDH3" EXACT []
synonym: "glutamate dehydrogenase (NADP(+)) GDH3" EXACT []

[Term]
id: sgd:S000000059
name: YAL063C
def: "Lectin-like protein with similarity to Flo1p; thought to be expressed and involved in flocculation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLO9" EXACT []
synonym: "flocculin FLO9" EXACT []

[Term]
id: sgd:S000000060
name: YAL064W
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000061
name: YAL066W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000062
name: YAL067C
def: "Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEO1" EXACT []
synonym: "putative permease SEO1" EXACT []

[Term]
id: sgd:S000000063
name: YAR002W
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex \(NPC\) permeability barrier and is involved in gene tethering at the nuclear periphery; relocalizes to the cytosol in response to hypoxia; both NUP1 and NUP60 are homologous to human NUP153" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP60" EXACT []
synonym: "NUP60" EXACT []

[Term]
id: sgd:S000000064
name: YAR003W
def: "Subunit of the COMPASS \(Set1C\) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COMPASS subunit protein SWD1" EXACT []
synonym: "CPS50" EXACT []
synonym: "FUN16" EXACT []
synonym: "SAF49" EXACT []
synonym: "SWD1" EXACT []

[Term]
id: sgd:S000000065
name: YAR007C
def: "Subunit of heterotrimeric Replication Protein A \(RPA\); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication\, repair\, and recombination; RPA protects against inappropriate telomere recombination\, and upon telomere uncapping\, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUF2" EXACT []
synonym: "FUN3" EXACT []
synonym: "RFA1" EXACT []
synonym: "RPA1" EXACT []
synonym: "RPA70" EXACT []
synonym: "replication factor A subunit protein RFA1" EXACT []

[Term]
id: sgd:S000000066
name: YAR008W
def: "Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p\, Sen15p\, Sen34p\, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN4" EXACT []
synonym: "SEN34" EXACT []
synonym: "tRNA splicing endonuclease subunit SEN34" EXACT []

[Term]
id: sgd:S000000069
name: YAR014C
def: "Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p \(formin\); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD14" EXACT []
synonym: "protein phosphatase regulator BUD14" EXACT []

[Term]
id: sgd:S000000070
name: YAR015W
def: "N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE1" EXACT []
synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthase" EXACT []

[Term]
id: sgd:S000000071
name: YAR018C
def: "Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN52" EXACT []
synonym: "KIN3" EXACT []
synonym: "NPK1" EXACT []
synonym: "serine/threonine protein kinase KIN3" EXACT []

[Term]
id: sgd:S000000072
name: YAR019C
def: "Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC15" EXACT []
synonym: "LYT1" EXACT []
synonym: "serine/threonine protein kinase CDC15" EXACT []

[Term]
id: sgd:S000000073
name: YAR020C
def: "Member of the seripauperin multigene family; active during alcoholic fermentation\, regulated by anaerobiosis\, inhibited by oxygen\, repressed by heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU7" EXACT []
synonym: "seripauperin PAU7" EXACT []

[Term]
id: sgd:S000000074
name: YAR023C
def: "Putative integral membrane protein; member of DUP240 gene family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein" EXACT []

[Term]
id: sgd:S000000075
name: YAR027W
def: "Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein UIP3" EXACT []
synonym: "UIP3" EXACT []

[Term]
id: sgd:S000000076
name: YAR028W
def: "Putative integral membrane protein; member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein" EXACT []

[Term]
id: sgd:S000000077
name: YAR029W
def: "Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein" EXACT []

[Term]
id: sgd:S000000078
name: YAR031W
def: "Pheromone-regulated protein; contains 3 predicted transmembrane segments and an FF sequence\, a motif involved in COPII binding; member of DUP240 gene family; PRM9 has a paralog\, PRM8\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM9" EXACT []
synonym: "pheromone-regulated DUP240 family protein PRM9" EXACT []

[Term]
id: sgd:S000000079
name: YAR033W
def: "Putative integral membrane protein\, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles; MST28 has a paralog\, MST27\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein MST28" EXACT []
synonym: "MST28" EXACT []

[Term]
id: sgd:S000000080
name: YAR035W
def: "Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAT1" EXACT []
synonym: "carnitine O-acetyltransferase YAT1" EXACT []

[Term]
id: sgd:S000000081
name: YAR042W
def: "Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction; SWH1 has a paralog\, OSH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSH1" EXACT []
synonym: "SWH1" EXACT []
synonym: "YAR044W" EXACT []
synonym: "oxysterol-binding protein related protein SWH1" EXACT []

[Term]
id: sgd:S000000083
name: YAR047C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000084
name: YAR050W
def: "Lectin-like protein involved in flocculation; cell wall protein that binds mannose chains on the surface of other cells\, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; FLO1 has a paralog\, FLO5\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLO1" EXACT []
synonym: "FLO2" EXACT []
synonym: "FLO4" EXACT []
synonym: "flocculin FLO1" EXACT []

[Term]
id: sgd:S000000085
name: YAR053W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000086
name: YAR060C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YAR060C has a paralog\, YHR212C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000089
name: YAR064W
def: "Pseudogenic fragment with similarity to flocculins; YAR064W has a paralog\, YHR213W-B\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000091
name: YAR068W
def: "Fungal-specific protein of unknown function; induced in respiratory-deficient cells; YAR068W has a paralog\, YHR214W-A\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000092
name: YAR069C
def: "Dubious open reading frame; unlikely to encode a protein\, based on available experimental and comparative sequence data; YAR069C has a paralog\, YHR214C-D\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000093
name: YAR070C
def: "Dubious open reading frame; unlikely to encode a protein\, based on available experimental and comparative sequence data; YAR070C has a paralog\, YHR214C-B\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000094
name: YAR071W
def: "One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog\, PHO12\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO11" EXACT []
synonym: "acid phosphatase PHO11" EXACT []

[Term]
id: sgd:S000000095
name: YAR073W
def: "Nonfunctional protein with homology to IMP dehydrogenase; blocked reading frame\, located close to the telomere; not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog\, IMD2\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMD1" EXACT []

[Term]
id: sgd:S000000097
name: YBL001C
def: "Non-essential protein of unknown function; likely exists as tetramer\, may be regulated by the binding of small-molecule ligands \(possibly sulfate ions\)\, may have a role in yeast cell-wall biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM15" EXACT []

[Term]
id: sgd:S000000098
name: YBL002W
def: "Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication\, transcriptional activation\, meiotic DSB formation and H3 methylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTB2" EXACT []
synonym: "histone H2B" EXACT []

[Term]
id: sgd:S000000099
name: YBL003C
def: "Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical \(see also HTA1\) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H2A2" EXACT []
synonym: "HTA2" EXACT []
synonym: "histone H2A" EXACT []

[Term]
id: sgd:S000000100
name: YBL004W
def: "Component of the small-subunit \(SSU\) processome; SSU processome is involved in the biogenesis of the 18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP20" EXACT []

[Term]
id: sgd:S000000101
name: YBL005W
def: "Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette \(ABC\) transporters through binding to cis-acting PDRE sites \(PDR responsive elements\); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC\(Cdh1\) substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMY2" EXACT []
synonym: "PDR3" EXACT []
synonym: "TPE2" EXACT []
synonym: "drug-responsive transcription factor PDR3" EXACT []

[Term]
id: sgd:S000000102
name: YBL006C
def: "Component of the RSC chromatin remodeling complex; interacts with Rsc3p\, Rsc30p\, Npl6p\, and Htl1p to form a module important for a broad range of RSC functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB7" EXACT []
synonym: "RSC14" EXACT []

[Term]
id: sgd:S000000103
name: YBL007C
def: "Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLA1" EXACT []
synonym: "cytoskeletal protein-binding protein SLA1" EXACT []

[Term]
id: sgd:S000000104
name: YBL008W
def: "Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation\, heterochromatic gene silencing\, and formation of functional kinetochores" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIR1" EXACT []

[Term]
id: sgd:S000000105
name: YBL009W
def: "Protein kinase; along with its paralog\, ALK1\, required for proper spindle positioning and nuclear segregation following mitotic arrest\, proper organization of cell polarity factors in mitosis\, proper localization of formins and polarity factors\, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog\, ALK1\, that arose from the whole genome duplication; similar to mammalian haspins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALK2" EXACT []
synonym: "protein kinase ALK2" EXACT []

[Term]
id: sgd:S000000106
name: YBL010C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein colocalizes with clathrin-coated vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000107
name: YBL011W
def: "Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT2" EXACT []
synonym: "SCT1" EXACT []
synonym: "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1" EXACT []

[Term]
id: sgd:S000000108
name: YBL012C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000109
name: YBL013W
def: "Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMT1" EXACT []

[Term]
id: sgd:S000000110
name: YBL014C
def: "Component of the core factor \(CF\) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p\, Rrn7p\, and Rrn11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN6" EXACT []

[Term]
id: sgd:S000000111
name: YBL015W
def: "Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACH1" EXACT []

[Term]
id: sgd:S000000112
name: YBL016W
def: "Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p\, Far1p\, Bni1p\, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p\, promoting its; inhibits recruitment of Ste5p\, Cdc42p-mediated asymmetry and mating morphogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAC2" EXACT []
synonym: "FUS3" EXACT []
synonym: "mitogen-activated serine/threonine-protein kinase FUS3" EXACT []

[Term]
id: sgd:S000000113
name: YBL017C
def: "Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP1" EXACT []
synonym: "VPS10" EXACT []
synonym: "VPT1" EXACT []

[Term]
id: sgd:S000000114
name: YBL018C
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP8" EXACT []

[Term]
id: sgd:S000000115
name: YBL019W
def: "Class II abasic \(AP\) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APN2" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) lyase APN2" EXACT []
synonym: "ETH1" EXACT []

[Term]
id: sgd:S000000116
name: YBL020W
def: "Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFT1" EXACT []

[Term]
id: sgd:S000000117
name: YBL021C
def: "Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAP3" EXACT []

[Term]
id: sgd:S000000118
name: YBL022C
def: "ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent Lon protease PIM1" EXACT []
synonym: "LON1" EXACT []
synonym: "PIM1" EXACT []

[Term]
id: sgd:S000000119
name: YBL023C
def: "Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCM DNA helicase complex subunit MCM2" EXACT []
synonym: "MCM2" EXACT []

[Term]
id: sgd:S000000120
name: YBL024W
def: "S-adenosyl-L-methionine-dependent tRNA\: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu\(CAA\) with m5C at wobble position in response to hydrogen peroxide\, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCL1" EXACT []
synonym: "TRM4" EXACT []

[Term]
id: sgd:S000000121
name: YBL025W
def: "Protein involved in promoting high level transcription of rDNA; subunit of UAF \(upstream activation factor\) for RNA polymerase I" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN10" EXACT []

[Term]
id: sgd:S000000122
name: YBL026W
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM2" EXACT []
synonym: "SMX5" EXACT []
synonym: "SNP3" EXACT []
synonym: "Sm-like protein LSM2" EXACT []

[Term]
id: sgd:S000000123
name: YBL027W
def: "Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth\, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19\, no bacterial homolog; RPL19B has a paralog\, RPL19A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L19B" EXACT []
synonym: "L19e" EXACT []
synonym: "L23B" EXACT []
synonym: "RPL19B" EXACT []
synonym: "YL14" EXACT []
synonym: "ribosomal 60S subunit protein L19B" EXACT []
synonym: "rpl5L" EXACT []

[Term]
id: sgd:S000000124
name: YBL028C
def: "Protein of unknown function that may interact with ribosomes; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000125
name: YBL029W
def: "Non-essential protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000126
name: YBL030C
def: "Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog\, AAC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAC2" EXACT []
synonym: "ADP/ATP carrier protein PET9" EXACT []
synonym: "ANC2" EXACT []
synonym: "OP1" EXACT []
synonym: "PET9" EXACT []

[Term]
id: sgd:S000000127
name: YBL031W
def: "Mitotic spindle protein; interacts with components of the Dam1 \(DASH\) complex\, its effector Sli15p\, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHE1" EXACT []

[Term]
id: sgd:S000000128
name: YBL032W
def: "RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA\, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEK2" EXACT []
synonym: "KHD1" EXACT []

[Term]
id: sgd:S000000129
name: YBL033C
def: "GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTP cyclohydrolase II" EXACT []
synonym: "RIB1" EXACT []

[Term]
id: sgd:S000000130
name: YBL034C
def: "Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin \(Tub2p\); required for interpolar microtubules to provide an outward force on the spindle poles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STU1" EXACT []

[Term]
id: sgd:S000000131
name: YBL035C
def: "B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-directed DNA polymerase alpha subunit POL12" EXACT []
synonym: "POL12" EXACT []

[Term]
id: sgd:S000000132
name: YBL036C
def: "Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000133
name: YBL037W
def: "Alpha-adaptin; large subunit of the clathrin associated protein complex \(AP-2\); involved in vesicle mediated transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL3" EXACT []

[Term]
id: sgd:S000000134
name: YBL038W
def: "Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL16" EXACT []
synonym: "RML16" EXACT []
synonym: "YmL47" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL47" EXACT []

[Term]
id: sgd:S000000135
name: YBL039C
def: "Major CTP synthase isozyme \(see also URA8\); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP\, forming CTP\, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium\, especially during conditions of glucose depletion; URA7 has a paralog\, URA8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTP synthase URA7" EXACT []
synonym: "URA7" EXACT []

[Term]
id: sgd:S000000136
name: YBL040C
def: "HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERD2" EXACT []

[Term]
id: sgd:S000000137
name: YBL041W
def: "Beta 6 subunit of the 20S proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE7" EXACT []
synonym: "PRS3" EXACT []
synonym: "proteasome core particle subunit beta 6" EXACT []

[Term]
id: sgd:S000000138
name: YBL042C
def: "High affinity uridine permease\, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUI1" EXACT []

[Term]
id: sgd:S000000139
name: YBL043W
def: "Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog\, YJR115W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM13" EXACT []

[Term]
id: sgd:S000000140
name: YBL044W
def: "Putative protein of unknown function; YBL044W is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000141
name: YBL045C
def: "Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex \(bc1 complex\) is a component of the mitochondrial inner membrane electron transport chain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COR1" EXACT []
synonym: "QCR1" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit COR1" EXACT []

[Term]
id: sgd:S000000142
name: YBL046W
def: "Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex \(along with catalytic subunit Pph3p and Psy2p\) is required for dephosphorylation of the histone variant H2AX\, but not for dephosphorylation of Rad53p\, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSY4" EXACT []

[Term]
id: sgd:S000000143
name: YBL047C
def: "Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD15" EXACT []
synonym: "EDE1" EXACT []

[Term]
id: sgd:S000000144
name: YBL048W
def: "Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein\, based on experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT1" EXACT []

[Term]
id: sgd:S000000145
name: YBL049W
def: "Protein of unknown function; has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase; possibly linked with vacuolar transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOH1" EXACT []

[Term]
id: sgd:S000000146
name: YBL050W
def: "Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 \(NSF\) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi\, the 'priming' step in homotypic vacuole fusion\, and autophagy; similar to mammalian alpha-SNAP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNS3" EXACT []
synonym: "SEC17" EXACT []

[Term]
id: sgd:S000000147
name: YBL051C
def: "Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif\, a nuclear localization signal\, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDT1" EXACT []
synonym: "PIN4" EXACT []

[Term]
id: sgd:S000000148
name: YBL052C
def: "Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3\, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAT6" EXACT []
synonym: "SAS3" EXACT []

[Term]
id: sgd:S000000149
name: YBL053W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000150
name: YBL054W
def: "PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBF1" EXACT []
synonym: "TOD6" EXACT []

[Term]
id: sgd:S000000151
name: YBL055C
def: "3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3'-5'-exodeoxyribonuclease" EXACT []
synonym: "Tat-D" EXACT []

[Term]
id: sgd:S000000152
name: YBL056W
def: "Type 2C protein phosphatase \(PP2C\); dephosphorylates Hog1p \(see also Ptc2p\) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p \(see also Ptc2p\); role in DNA damage checkpoint inactivation; PTC3 has a paralog\, PTC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTC3" EXACT []
synonym: "type 2C protein phosphatase PTC3" EXACT []

[Term]
id: sgd:S000000153
name: YBL057C
def: "One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTH2" EXACT []

[Term]
id: sgd:S000000154
name: YBL058W
def: "UBX \(ubiquitin regulatory X\) domain-containing protein; regulates Glc7p phosphatase activity; shp1 mutants are impaired in growth and mitotic progression; functions in growth and mitotic progression require Cdc48p binding; mitotic phenotype is caused by reduced Glc7p activity; interacts with ubiquitylated proteins\, required for degradation of a ubiquitylated model substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHP1" EXACT []
synonym: "UBX1" EXACT []
synonym: "protein phosphatase regulator SHP1" EXACT []

[Term]
id: sgd:S000000155
name: YBL059W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog\, YER093C-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000156
name: YBL060W
def: "Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor YEL1" EXACT []
synonym: "YEL1" EXACT []

[Term]
id: sgd:S000000157
name: YBL061C
def: "Activator of Chs3p \(chitin synthase III\) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog\, SHC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAL2" EXACT []
synonym: "CHS4" EXACT []
synonym: "CSD4" EXACT []
synonym: "SKT5" EXACT []

[Term]
id: sgd:S000000158
name: YBL062W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000159
name: YBL063W
def: "Kinesin-related motor protein; required for mitotic spindle assembly\, chromosome segregation\, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIN9" EXACT []
synonym: "KIP1" EXACT []

[Term]
id: sgd:S000000160
name: YBL064C
def: "Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRX1" EXACT []

[Term]
id: sgd:S000000161
name: YBL065W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000162
name: YBL066C
def: "Putative transcription factor; has homolog in Kluyveromyces lactis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEF1" EXACT []

[Term]
id: sgd:S000000163
name: YBL067C
def: "Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog\, UBP9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP13" EXACT []

[Term]
id: sgd:S000000164
name: YBL068W
def: "5-phospho-ribosyl-1\(alpha\)-pyrophosphate synthetase\, synthesizes PRPP; which is required for nucleotide\, histidine\, and tryptophan biosynthesis; one of five related enzymes\, which are active as heteromultimeric complexes; PRS4 has a paralog\, PRS2\, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRS4" EXACT []
synonym: "ribose phosphate diphosphokinase subunit PRS4" EXACT []

[Term]
id: sgd:S000000165
name: YBL069W
def: "Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases \(MDRs\) superfamily; AST1 has a paralog\, AST2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AST1" EXACT []

[Term]
id: sgd:S000000166
name: YBL070C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000167
name: YBL071C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000168
name: YBL072C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S8\, no bacterial homolog; RPS8A has a paralog\, RPS8B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS8A" EXACT []
synonym: "S14A" EXACT []
synonym: "S8A" EXACT []
synonym: "S8e" EXACT []
synonym: "YS9" EXACT []
synonym: "ribosomal 40S subunit protein S8A" EXACT []
synonym: "rp19" EXACT []

[Term]
id: sgd:S000000169
name: YBL073W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000170
name: YBL074C
def: "Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAR2" EXACT []

[Term]
id: sgd:S000000171
name: YBL075C
def: "ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 \(HSP70\) family; localized to the cytoplasm; SSA3 has a paralog\, SSA4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family ATPase SSA3" EXACT []
synonym: "SSA3" EXACT []
synonym: "YG106" EXACT []

[Term]
id: sgd:S000000172
name: YBL076C
def: "Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILS1" EXACT []
synonym: "isoleucine--tRNA ligase ILS1" EXACT []

[Term]
id: sgd:S000000173
name: YBL077W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000174
name: YBL078C
def: "Component of autophagosomes and Cvt vesicles; regulator of Atg1p\, targets it to autophagosomes; binds the Atg1p-Atg13p complex\, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine \(PE\); Atg8p-PE is anchored to membranes\, is involved in phagophore expansion\, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG8" EXACT []
synonym: "ATG8" EXACT []
synonym: "AUT7" EXACT []
synonym: "CVT5" EXACT []
synonym: "ubiquitin-like protein ATG8" EXACT []

[Term]
id: sgd:S000000175
name: YBL079W
def: "Subunit of the inner ring of the nuclear pore complex \(NPC\); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog\, NUP157\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NLE3" EXACT []
synonym: "NUP170" EXACT []

[Term]
id: sgd:S000000176
name: YBL080C
def: "Subunit of the trimeric GatFAB AmidoTransferase\(AdT\) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET112" EXACT []
synonym: "glutamyl-tRNA(Gln) amidotransferase subunit PET112" EXACT []

[Term]
id: sgd:S000000177
name: YBL081W
def: "Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000178
name: YBL082C
def: "Dolichol-P-Man dependent alpha\(1-3\) mannosyltransferase; involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-mannosyltransferase" EXACT []
synonym: "ALG3" EXACT []
synonym: "RHK1" EXACT []
synonym: "dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000000179
name: YBL083C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps verified ORF ALG3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000180
name: YBL084C
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC3" EXACT []
synonym: "CDC27" EXACT []
synonym: "SNB1" EXACT []
synonym: "anaphase promoting complex subunit CDC27" EXACT []

[Term]
id: sgd:S000000181
name: YBL085W
def: "Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 \(src homology 3\) domain and a PH \(pleckstrin homology\) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog\, BOI2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOB1" EXACT []
synonym: "BOI1" EXACT []
synonym: "GIN7" EXACT []

[Term]
id: sgd:S000000182
name: YBL086C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000183
name: YBL087C
def: "Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog\, RPL23B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L14" EXACT []
synonym: "L17aA" EXACT []
synonym: "L23A" EXACT []
synonym: "RPL23A" EXACT []
synonym: "YL32" EXACT []
synonym: "ribosomal 60S subunit protein L23A" EXACT []

[Term]
id: sgd:S000000184
name: YBL088C
def: "Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated \(ATM\) gene\, the gene responsible for ataxia telangiectasia \(AT\) \(OMIM 607585\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding protein kinase TEL1" EXACT []
synonym: "TEL1" EXACT []

[Term]
id: sgd:S000000185
name: YBL089W
def: "Putative transporter; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters; AVT5 has a paralog\, AVT6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT5" EXACT []

[Term]
id: sgd:S000000186
name: YBL090W
def: "Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP21" EXACT []
synonym: "MRP50" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRP21" EXACT []

[Term]
id: sgd:S000000187
name: YBL091C
def: "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAP2" EXACT []

[Term]
id: sgd:S000000188
name: YBL092W
def: "Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L32" EXACT []
synonym: "L32e" EXACT []
synonym: "RPL32" EXACT []
synonym: "ribosomal 60S subunit protein L32" EXACT []

[Term]
id: sgd:S000000189
name: YBL093C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED19" EXACT []
synonym: "NUT3" EXACT []
synonym: "ROX3" EXACT []
synonym: "SSN7" EXACT []
synonym: "SSX2" EXACT []

[Term]
id: sgd:S000000190
name: YBL094C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000191
name: YBL095W
def: "Putative protein of unknown function; likely functions in cristae junction formation; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000192
name: YBL096C
def: "Non-essential protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000193
name: YBL097W
def: "Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRN1" EXACT []

[Term]
id: sgd:S000000194
name: YBL098W
def: "Kynurenine 3-mono oxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA4" EXACT []
synonym: "kynurenine 3-monooxygenase" EXACT []

[Term]
id: sgd:S000000195
name: YBL099W
def: "Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP1" EXACT []
synonym: "F1F0 ATP synthase subunit alpha" EXACT []

[Term]
id: sgd:S000000196
name: YBL100C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000197
name: YBL101C
def: "Protein involved in regulating endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements; ECM21 has a paralog\, CSR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART2" EXACT []
synonym: "ECM21" EXACT []

[Term]
id: sgd:S000000198
name: YBL102W
def: "Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery\, but precise function is unknown; similar to mammalian syntaxin 5" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFT2" EXACT []

[Term]
id: sgd:S000000199
name: YBL103C
def: "bHLH/Zip transcription factor for retrograde \(RTG\) and TOR pathways; forms a complex with another bHLH/Zip protein\, Rtg1p\, to activate the pathways; target of Hog1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTG3" EXACT []

[Term]
id: sgd:S000000200
name: YBL104C
def: "Subunit of the SEA \(Seh1-associated\) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEA4" EXACT []
synonym: "YBL103C-A" EXACT []

[Term]
id: sgd:S000000201
name: YBL105C
def: "Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha\, beta\, and gamma isoforms of mammalian protein kinase C \(PKC\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLY15" EXACT []
synonym: "CLY5" EXACT []
synonym: "CLY7" EXACT []
synonym: "HPO2" EXACT []
synonym: "PKC1" EXACT []
synonym: "STT1" EXACT []
synonym: "protein kinase C" EXACT []

[Term]
id: sgd:S000000202
name: YBL106C
def: "Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog\, SRO7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNI2" EXACT []
synonym: "SOP2" EXACT []
synonym: "SRO77" EXACT []

[Term]
id: sgd:S000000203
name: YBL107C
def: "Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif \(CX13C CX14C\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIC23" EXACT []
synonym: "MIX23" EXACT []

[Term]
id: sgd:S000000204
name: YBL108W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000205
name: YBR001C
def: "Putative neutral trehalase\, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog\, NTH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTH2" EXACT []
synonym: "alpha" EXACT []
synonym: "alpha-trehalase NTH2" EXACT []

[Term]
id: sgd:S000000206
name: YBR002C
def: "Cis-prenyltransferase involved in dolichol synthesis; major enzyme of polyprenol synthesis in both the endoplasmic reticulum \(ER\) and in lipid droplets; participates in ER protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RER2" EXACT []

[Term]
id: sgd:S000000207
name: YBR003W
def: "Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone \(coenzyme Q\) biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ1" EXACT []
synonym: "trans-hexaprenyltranstransferase" EXACT []

[Term]
id: sgd:S000000208
name: YBR004C
def: "Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic\, non-tagged protein was localized to mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP44" EXACT []
synonym: "GPI18" EXACT []

[Term]
id: sgd:S000000209
name: YBR005W
def: "Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway\, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog\, RCR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCR1" EXACT []
synonym: "SSH6" EXACT []

[Term]
id: sgd:S000000210
name: YBR006W
def: "Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate \(GABA\) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGA2" EXACT []
synonym: "UGA5" EXACT []
synonym: "succinate-semialdehyde dehydrogenase (NAD(P)(+))" EXACT []

[Term]
id: sgd:S000000211
name: YBR007C
def: "Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSF2" EXACT []

[Term]
id: sgd:S000000212
name: YBR008C
def: "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; involved in efflux of fluconazole\, diazaborine\, benomyl\, methotrexate\, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLR1" EXACT []

[Term]
id: sgd:S000000213
name: YBR009C
def: "Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins \(see also HHF2\); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HHF1" EXACT []
synonym: "histone H4" EXACT []

[Term]
id: sgd:S000000214
name: YBR010W
def: "Histone H3; core histone protein required for chromatin assembly\, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins \(see HHT2\); regulated by acetylation\, methylation\, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUR5" EXACT []
synonym: "HHT1" EXACT []
synonym: "SIN2" EXACT []
synonym: "histone H3" EXACT []

[Term]
id: sgd:S000000215
name: YBR011C
def: "Cytoplasmic inorganic pyrophosphatase \(PPase\); homodimer that catalyzes the rapid exchange of oxygens from Pi with water\, highly expressed and essential for viability\, active-site residues show identity to those from E. coli PPase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPP1" EXACT []
synonym: "PPA1" EXACT []
synonym: "inorganic diphosphatase IPP1" EXACT []

[Term]
id: sgd:S000000216
name: YBR012C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; expression induced by iron-regulated transcriptional activator Aft2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000217
name: YBR013C
def: "Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000218
name: YBR014C
def: "Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog\, GRX6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX7" EXACT []
synonym: "glutathione-disulfide reductase GRX7" EXACT []

[Term]
id: sgd:S000000219
name: YBR015C
def: "Alpha-1\,2-mannosyltransferase; responsible for addition of the first alpha-1\,2-linked mannose to form the branches on the mannan backbone of oligosaccharides\, localizes to an early Golgi compartment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRV4" EXACT []
synonym: "LDB8" EXACT []
synonym: "MNN2" EXACT []
synonym: "TTP1" EXACT []

[Term]
id: sgd:S000000220
name: YBR016W
def: "Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins\, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog\, YDL012C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000221
name: YBR017C
def: "Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP104" EXACT []

[Term]
id: sgd:S000000222
name: YBR018C
def: "Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL7" EXACT []
synonym: "UDP-glucose:hexose-1-phosphate uridylyltransferase" EXACT []

[Term]
id: sgd:S000000223
name: YBR019C
def: "UDP-glucose-4-epimerase; catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL10" EXACT []
synonym: "bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase" EXACT []

[Term]
id: sgd:S000000224
name: YBR020W
def: "Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog\, GAL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL1" EXACT []
synonym: "galactokinase" EXACT []

[Term]
id: sgd:S000000225
name: YBR021W
def: "Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUR4" EXACT []

[Term]
id: sgd:S000000226
name: YBR022W
def: "Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POA1" EXACT []

[Term]
id: sgd:S000000227
name: YBR023C
def: "Chitin synthase III; catalyzes the transfer of N-acetylglucosamine \(GlcNAc\) to chitin; required for synthesis of the majority of cell wall chitin\, the chitin ring during bud emergence\, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate\, respectively\, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAL1" EXACT []
synonym: "CHS3" EXACT []
synonym: "CSD2" EXACT []
synonym: "DIT101" EXACT []
synonym: "KTI2" EXACT []
synonym: "chitin synthase CHS3" EXACT []

[Term]
id: sgd:S000000228
name: YBR024W
def: "Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog\, SCO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCO2" EXACT []

[Term]
id: sgd:S000000229
name: YBR025C
def: "P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OLA1" EXACT []

[Term]
id: sgd:S000000230
name: YBR026C
def: "2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to in mitochondria\, where it has a probable role in fatty acid synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ETR1" EXACT []
synonym: "MRF1" EXACT []
synonym: "MRF1'" EXACT []

[Term]
id: sgd:S000000231
name: YBR027C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000232
name: YBR028C
def: "AGC kinase; phosphorylated by cAMP-dependent protein kinase \(PKA\) in a TORC1-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPK3" EXACT []
synonym: "putative protein kinase YPK3" EXACT []

[Term]
id: sgd:S000000233
name: YBR029C
def: "Phosphatidate cytidylyltransferase \(CDP-diglyceride synthetase\); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol\, a critical step in the synthesis of all major yeast phospholipids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDG1" EXACT []
synonym: "CDS1" EXACT []
synonym: "phosphatidate cytidylyltransferase" EXACT []

[Term]
id: sgd:S000000234
name: YBR030W
def: "Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp \(lysine 40\); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKM3" EXACT []

[Term]
id: sgd:S000000235
name: YBR031W
def: "Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog\, RPL4B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L2A" EXACT []
synonym: "L4" EXACT []
synonym: "L4A" EXACT []
synonym: "RPL4A" EXACT []
synonym: "YL2" EXACT []
synonym: "ribosomal 60S subunit protein L4A" EXACT []
synonym: "rp2" EXACT []

[Term]
id: sgd:S000000236
name: YBR032W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000237
name: YBR033W
def: "Putative zinc cluster protein\, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog\, RGT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EDS1" EXACT []

[Term]
id: sgd:S000000238
name: YBR034C
def: "Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs\, including Npl3p and Hrp1p\, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3\(L\) and this interaction is important for Rpd3 recruitment to the subtelomeric region." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCP1" EXACT []
synonym: "HMT1" EXACT []
synonym: "ODP1" EXACT []
synonym: "RMT1" EXACT []
synonym: "protein-arginine omega-N  methyltransferase HMT1" EXACT []

[Term]
id: sgd:S000000239
name: YBR035C
def: "Pyridoxine \(pyridoxamine\) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDX3" EXACT []
synonym: "pyridoxamine-phosphate oxidase PDX3" EXACT []

[Term]
id: sgd:S000000240
name: YBR036C
def: "Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS2" EXACT []
synonym: "CSG2" EXACT []
synonym: "mannosylinositol phosphorylceramide synthase regulatory subunit" EXACT []

[Term]
id: sgd:S000000241
name: YBR037C
def: "Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog\, SCO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET161" EXACT []
synonym: "SCO1" EXACT []

[Term]
id: sgd:S000000242
name: YBR038W
def: "Chitin synthase II; catalyzes transfer of N-acetylglucosamine \(GlcNAc\) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHS2" EXACT []
synonym: "chitin synthase CHS2" EXACT []

[Term]
id: sgd:S000000243
name: YBR039W
def: "Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP3" EXACT []
synonym: "F1F0 ATP synthase subunit gamma" EXACT []

[Term]
id: sgd:S000000244
name: YBR040W
def: "Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system\, which affects intracellular signaling and cell-cell fusion during mating" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIG1" EXACT []

[Term]
id: sgd:S000000245
name: YBR041W
def: "Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths \(C20-C26\); has a separate function in the transport of long chain fatty acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAT1" EXACT []
synonym: "long-chain fatty acid transporter FAT1" EXACT []

[Term]
id: sgd:S000000246
name: YBR042C
def: "Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog\, YDR018C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST26" EXACT []
synonym: "PSI1" EXACT []

[Term]
id: sgd:S000000247
name: YBR043C
def: "Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1\, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine\, barban\, cisplatin\, and bleomycin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AQR2" EXACT []
synonym: "QDR3" EXACT []

[Term]
id: sgd:S000000248
name: YBR044C
def: "Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCM62" EXACT []

[Term]
id: sgd:S000000249
name: YBR045C
def: "Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization\, required for expression of some late meiotic genes and for normal localization of Glc7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIP1" EXACT []
synonym: "protein phosphatase regulator GIP1" EXACT []

[Term]
id: sgd:S000000250
name: YBR046C
def: "NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZTA1" EXACT []

[Term]
id: sgd:S000000251
name: YBR047W
def: "Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP23" EXACT []

[Term]
id: sgd:S000000252
name: YBR048W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog\, RPS11A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS11B" EXACT []
synonym: "S11B" EXACT []
synonym: "S17" EXACT []
synonym: "S18B" EXACT []
synonym: "YS12" EXACT []
synonym: "ribosomal 40S subunit protein S11B" EXACT []
synonym: "rp41B" EXACT []

[Term]
id: sgd:S000000253
name: YBR049C
def: "RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding protein REB1" EXACT []
synonym: "GRF2" EXACT []
synonym: "REB1" EXACT []

[Term]
id: sgd:S000000254
name: YBR050C
def: "Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p\, Glc7p\, and Snf1p in regulation of glucose-repressible genes\, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog\, REG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REG2" EXACT []
synonym: "protein phosphatase regulator REG2" EXACT []

[Term]
id: sgd:S000000255
name: YBR051W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000256
name: YBR052C
def: "Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog\, PST2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFS1" EXACT []

[Term]
id: sgd:S000000257
name: YBR053C
def: "Putative protein of unknown function; induced by cell wall perturbation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000258
name: YBR054W
def: "Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic\, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YRO2" EXACT []

[Term]
id: sgd:S000000259
name: YBR055C
def: "Splicing factor; component of the U4/U6-U5 snRNP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP6" EXACT []
synonym: "RNA6" EXACT []
synonym: "TSM7269" EXACT []

[Term]
id: sgd:S000000260
name: YBR056W
def: "Putative glycoside hydrolase of the mitochondrial intermembrane space" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "17-beta-hydroxysteroid dehydrogenase-like protein" EXACT []

[Term]
id: sgd:S000000261
name: YBR057C
def: "Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p\, which is a component of the origin recognition complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUM2" EXACT []
synonym: "SPOT8" EXACT []

[Term]
id: sgd:S000000262
name: YBR058C
def: "Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1\,6-bisphosphatase \(Fbp1p\) degradation; similar to human isopeptidase T" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID6" EXACT []
synonym: "UBP14" EXACT []

[Term]
id: sgd:S000000263
name: YBR059C
def: "Ser-Thr protein kinase; member \(with Ark1p and Prk1p\) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AKL1" EXACT []
synonym: "serine/threonine protein kinase AKL1" EXACT []

[Term]
id: sgd:S000000264
name: YBR060C
def: "Subunit of the origin recognition complex \(ORC\); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC2" EXACT []
synonym: "RRR1" EXACT []
synonym: "SIR5" EXACT []
synonym: "origin recognition complex subunit 2" EXACT []

[Term]
id: sgd:S000000265
name: YBR061C
def: "2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe\, tRNA-Trp\, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs\, respectively; functionally complemented by human FTSJ1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM7" EXACT []

[Term]
id: sgd:S000000266
name: YBR062C
def: "Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000267
name: YBR063C
def: "Putative protein of unknown function; YBR063C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000268
name: YBR064W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR063C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000269
name: YBR065C
def: "Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome\, function may be regulated by Slu7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM2" EXACT []
synonym: "SLT11" EXACT []

[Term]
id: sgd:S000000270
name: YBR066C
def: "Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRG2" EXACT []

[Term]
id: sgd:S000000271
name: YBR067C
def: "Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIP1" EXACT []

[Term]
id: sgd:S000000272
name: YBR068C
def: "High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine\, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog\, BAP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAP2" EXACT []
synonym: "branched-chain amino acid permease BAP2" EXACT []

[Term]
id: sgd:S000000273
name: YBR069C
def: "Amino acid transporter for valine\, leucine\, isoleucine\, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAP1" EXACT []
synonym: "TAT1" EXACT []
synonym: "VAP1" EXACT []
synonym: "amino acid transporter TAT1" EXACT []

[Term]
id: sgd:S000000274
name: YBR070C
def: "Component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALG14" EXACT []
synonym: "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14" EXACT []

[Term]
id: sgd:S000000275
name: YBR071W
def: "Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000276
name: YBR072W
def: "Small heat shock protein \(sHSP\) with chaperone activity; forms hollow\, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP26" EXACT []
synonym: "chaperone protein HSP26" EXACT []

[Term]
id: sgd:S000000277
name: YBR073W
def: "DNA-dependent ATPase; DNA recombination/repair translocase\, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks \(DSBs\) during mitosis and meiosis; phosphorylated in Mec1p-\, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-dependent ATPase RDH54" EXACT []
synonym: "RDH54" EXACT []
synonym: "TID1" EXACT []

[Term]
id: sgd:S000000278
name: YBR074W
def: "Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFF1" EXACT []
synonym: "YBR075W" EXACT []

[Term]
id: sgd:S000000280
name: YBR076W
def: "Non-essential protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM8" EXACT []

[Term]
id: sgd:S000000281
name: YBR077C
def: "Component of the EGO and GSE complexes; essential for integrity and function of EGO; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGO3" EXACT []
synonym: "GSE1" EXACT []
synonym: "NIR1" EXACT []
synonym: "SLM4" EXACT []

[Term]
id: sgd:S000000282
name: YBR078W
def: "GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog\, PST1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM33" EXACT []

[Term]
id: sgd:S000000283
name: YBR079C
def: "eIF3a subunit of the eukaryotic translation initiation factor 3 \(eIF3\); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA\(i\)Met to ribosomes; involved in translation reinitiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPG1" EXACT []
synonym: "TIF32" EXACT []

[Term]
id: sgd:S000000284
name: YBR080C
def: "AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi\, the 'priming' step in homotypic vacuole fusion\, autophagy\, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor \(NSF\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase SEC18" EXACT []
synonym: "ANU4" EXACT []
synonym: "SEC18" EXACT []

[Term]
id: sgd:S000000285
name: YBR081C
def: "Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIT2" EXACT []
synonym: "SAGA histone acetyltransferase complex subunit SPT7" EXACT []
synonym: "SPT7" EXACT []

[Term]
id: sgd:S000000286
name: YBR082C
def: "Ubiquitin-conjugating enzyme \(E2\); key E2 partner with Ubc1p for the anaphase-promoting complex \(APC\); mediates degradation of abnormal or excess proteins\, including calmodulin and histone H3; regulates levels of DNA Polymerase-\{alpha\} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog\, UBC5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-conjugating protein UBC4" EXACT []
synonym: "UBC4" EXACT []

[Term]
id: sgd:S000000287
name: YBR083W
def: "Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes\, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROC1" EXACT []
synonym: "TEC1" EXACT []

[Term]
id: sgd:S000000288
name: YBR084W
def: "Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate \(THF\); provides activities of formyl-THF synthetase\, methenyl-THF cyclohydrolase\, and methylene-THF dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIS1" EXACT []
synonym: "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1" EXACT []

[Term]
id: sgd:S000000289
name: YBR085W
def: "Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog\, PET9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAC3" EXACT []
synonym: "ADP/ATP carrier protein AAC3" EXACT []
synonym: "ANC3" EXACT []

[Term]
id: sgd:S000000290
name: YBR086C
def: "Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to the plasma membrane \(PM\) and regulate PM phosphatidylinositol-4-phosphate \(PI4P\) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IST2" EXACT []

[Term]
id: sgd:S000000291
name: YBR087W
def: "Subunit of heteropentameric Replication factor C \(RF-C\); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen \(PCNA\) processivity factor for DNA polymerases delta and epsilon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFC5" EXACT []
synonym: "replication factor C subunit 5" EXACT []

[Term]
id: sgd:S000000292
name: YBR088C
def: "Proliferating cell nuclear antigen \(PCNA\); functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCNA" EXACT []
synonym: "POL30" EXACT []
synonym: "proliferating cell nuclear antigen" EXACT []

[Term]
id: sgd:S000000293
name: YBR089W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000294
name: YBR090C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000295
name: YBR091C
def: "Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex\, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS5" EXACT []
synonym: "TIM12" EXACT []

[Term]
id: sgd:S000000296
name: YBR092C
def: "Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space\, increasing cellular thiamin uptake; expression is repressed by thiamin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO3" EXACT []
synonym: "acid phosphatase PHO3" EXACT []
synonym: "phoC" EXACT []

[Term]
id: sgd:S000000297
name: YBR093C
def: "Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO5" EXACT []
synonym: "acid phosphatase PHO5" EXACT []
synonym: "phoE" EXACT []

[Term]
id: sgd:S000000298
name: YBR094W
def: "Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBY1" EXACT []

[Term]
id: sgd:S000000299
name: YBR095C
def: "Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAF60" EXACT []
synonym: "RXT2" EXACT []

[Term]
id: sgd:S000000300
name: YBR096W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000301
name: YBR097W
def: "Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized\, with Vps34p\, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD8" EXACT []
synonym: "VAC4" EXACT []
synonym: "VPL19" EXACT []
synonym: "VPS15" EXACT []
synonym: "VPS40" EXACT []
synonym: "VPT15" EXACT []
synonym: "ubiquitin-binding serine/threonine protein kinase VPS15" EXACT []

[Term]
id: sgd:S000000302
name: YBR098W
def: "Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination\, DNA repair\, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMS4" EXACT []
synonym: "SLX2" EXACT []
synonym: "YBR100W" EXACT []

[Term]
id: sgd:S000000303
name: YBR099C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000305
name: YBR101C
def: "Hsp70 \(Ssa1p\) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p\, which is the nucleotide exchange factor for BiP \(Kar2p\) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FES1" EXACT []

[Term]
id: sgd:S000000306
name: YBR102C
def: "Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane \(PM\) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EXO84" EXACT []
synonym: "USA3" EXACT []

[Term]
id: sgd:S000000307
name: YBR103W
def: "WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMB1" EXACT []
synonym: "SIF2" EXACT []

[Term]
id: sgd:S000000308
name: YBR104W
def: "Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier \(MCF\) family; YMC2 has a paralog\, YMC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMC2" EXACT []

[Term]
id: sgd:S000000309
name: YBR105C
def: "GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1\,6-bisphosphatase \(FBPase\) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid \(vacuole import and degradation\) vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID4" EXACT []
synonym: "VID24" EXACT []
synonym: "glucose-induced degradation complex subunit VID24" EXACT []

[Term]
id: sgd:S000000310
name: YBR106W
def: "Probable membrane protein; involved in phosphate transport; role in the maturation of secretory proteins; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO88" EXACT []

[Term]
id: sgd:S000000311
name: YBR107C
def: "Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-L and fission yeast fta1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IML3" EXACT []
synonym: "MCM19" EXACT []

[Term]
id: sgd:S000000312
name: YBR108W
def: "Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM3" EXACT []

[Term]
id: sgd:S000000313
name: YBR109C
def: "Calmodulin; Ca++ binding protein that regulates Ca++ independent processes \(mitosis\, bud growth\, actin organization\, endocytosis\, etc.\) and Ca++ dependent processes \(stress-activated pathways\)\, targets include Nuf1p\, Myo2p and calcineurin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMD1" EXACT []
synonym: "CaM" EXACT []
synonym: "calmodulin" EXACT []

[Term]
id: sgd:S000000314
name: YBR110W
def: "Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum \(ER\); essential for viability\, mutation is functionally complemented by human ortholog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4 mannosyltransferase" EXACT []
synonym: "ALG1" EXACT []
synonym: "chitobiosyldiphosphodolichol beta-1" EXACT []

[Term]
id: sgd:S000000315
name: YBR111C
def: "Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMA2" EXACT []
synonym: "YSA1" EXACT []

[Term]
id: sgd:S000000316
name: YBR112C
def: "General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion \[OCT+\]" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT8" EXACT []
synonym: "CYC8" EXACT []
synonym: "SSN6" EXACT []
synonym: "[OCT1+]" EXACT []
synonym: "[OCT]" EXACT []
synonym: "transcription regulator CYC8" EXACT []

[Term]
id: sgd:S000000317
name: YBR113W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000318
name: YBR114W
def: "Nucleotide excision repair \(NER\) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner \(with Rad7p\) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 \(NEF4\) and the Elongin-Cullin-Socs \(ECS\) ligase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA repair protein RAD16" EXACT []
synonym: "PSO5" EXACT []
synonym: "RAD16" EXACT []

[Term]
id: sgd:S000000319
name: YBR115C
def: "Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde\, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L-aminoadipate-semialdehyde dehydrogenase" EXACT []
synonym: "LYS2" EXACT []

[Term]
id: sgd:S000000320
name: YBR116C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000321
name: YBR117C
def: "Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog\, TKL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TKL2" EXACT []
synonym: "transketolase TKL2" EXACT []

[Term]
id: sgd:S000000322
name: YBR118W
def: "Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA \(AA-tRNA\) to ribosomes; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog\, TEF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EF-1 alpha" EXACT []
synonym: "TEF2" EXACT []
synonym: "eEF1A" EXACT []
synonym: "translation elongation factor EF-1 alpha" EXACT []

[Term]
id: sgd:S000000323
name: YBR119W
def: "U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUD1" EXACT []
synonym: "U1-A" EXACT []
synonym: "U1A" EXACT []

[Term]
id: sgd:S000000324
name: YBR120C
def: "Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b \(Cobp\) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked\, downregulating COB mRNA translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP6" EXACT []

[Term]
id: sgd:S000000325
name: YBR121C
def: "Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog\, GRS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRS1" EXACT []
synonym: "glycine--tRNA ligase" EXACT []

[Term]
id: sgd:S000000326
name: YBR122C
def: "Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL36" EXACT []
synonym: "YmL36" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL36" EXACT []

[Term]
id: sgd:S000000327
name: YBR123C
def: "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex \(TFIIIC\); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFC1" EXACT []
synonym: "tau 95" EXACT []
synonym: "transcription factor TFIIIC subunit TFC1" EXACT []

[Term]
id: sgd:S000000328
name: YBR124W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000329
name: YBR125C
def: "Cytoplasmic type 2C protein phosphatase \(PP2C\); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCT1" EXACT []
synonym: "PTC4" EXACT []
synonym: "type 2C protein phosphatase PTC4" EXACT []

[Term]
id: sgd:S000000330
name: YBR126C
def: "Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BYP1" EXACT []
synonym: "CIF1" EXACT []
synonym: "FDP1" EXACT []
synonym: "GGS1" EXACT []
synonym: "GLC6" EXACT []
synonym: "TPS1" EXACT []
synonym: "TSS1" EXACT []
synonym: "alpha" EXACT []
synonym: "alpha-trehalose-phosphate synthase (UDP-forming) TPS1" EXACT []

[Term]
id: sgd:S000000331
name: YBR127C
def: "Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATPSV" EXACT []
synonym: "H(+)-transporting V1 sector ATPase subunit B" EXACT []
synonym: "VAT2" EXACT []
synonym: "VMA2" EXACT []

[Term]
id: sgd:S000000332
name: YBR128C
def: "Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site \(PAS\); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34\, Vps15\, and Vps30p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG14" EXACT []
synonym: "ATG14" EXACT []
synonym: "CVT12" EXACT []

[Term]
id: sgd:S000000333
name: YBR129C
def: "Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPY1" EXACT []

[Term]
id: sgd:S000000334
name: YBR130C
def: "Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHE3" EXACT []

[Term]
id: sgd:S000000335
name: YBR131W
def: "Subunit of a heterodimeric guanine nucleotide exchange factor \(GEF\); subunit of the Mon1-Ccz1 GEF complex\, which stimulates nucleotide exchange and activation of Ypt7p\, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy\, the CVT pathway and mitophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCZ1" EXACT []
synonym: "CVT16" EXACT []

[Term]
id: sgd:S000000336
name: YBR132C
def: "Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGP2" EXACT []

[Term]
id: sgd:S000000337
name: YBR133C
def: "Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment\, phosphorylation\, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSL7" EXACT []

[Term]
id: sgd:S000000338
name: YBR134W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000339
name: YBR135W
def: "Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p\(Cdk1p\); required for G1/S and G2/M phase transitions and budding; mediates the phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation\, recruiting proteasomal subunits to target gene promoters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKS1" EXACT []
synonym: "cyclin-dependent protein kinase regulatory subunit CKS1" EXACT []

[Term]
id: sgd:S000000340
name: YBR136W
def: "Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened\, dysfunctional telomeres" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESR1" EXACT []
synonym: "MEC1" EXACT []
synonym: "RAD31" EXACT []
synonym: "SAD3" EXACT []
synonym: "protein kinase MEC1" EXACT []

[Term]
id: sgd:S000000341
name: YBR137W
def: "Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex\, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000342
name: YBR138C
def: "Cytoplasmic protein of unknown function; APCC\(Cdh1\) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDR1" EXACT []

[Term]
id: sgd:S000000343
name: YBR139W
def: "Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3\, GAT1-independent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "carboxypeptidase C" EXACT []

[Term]
id: sgd:S000000344
name: YBR140C
def: "GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form\, required for reducing cAMP levels under nutrient limiting conditions\, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency\, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog\, IRA2\, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLC1" EXACT []
synonym: "IRA1" EXACT []
synonym: "PPD1" EXACT []

[Term]
id: sgd:S000000345
name: YBR141C
def: "Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine \(m1A\) of the large subunit \(LSU\) rRNA at position 2142; belongs to Rossmann fold superfamily; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BMT2" EXACT []

[Term]
id: sgd:S000000346
name: YBR142W
def: "Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large \(60S\) ribosomal subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK5" EXACT []

[Term]
id: sgd:S000000347
name: YBR143C
def: "Polypeptide release factor \(eRF1\) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAL4" EXACT []
synonym: "SUP1" EXACT []
synonym: "SUP45" EXACT []
synonym: "SUP47" EXACT []
synonym: "eRF1" EXACT []
synonym: "translation termination factor eRF1" EXACT []

[Term]
id: sgd:S000000348
name: YBR144C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YBR144C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000349
name: YBR145W
def: "Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog\, ADH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH5" EXACT []
synonym: "alcohol dehydrogenase ADH5" EXACT []

[Term]
id: sgd:S000000350
name: YBR146W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS9" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS9" EXACT []

[Term]
id: sgd:S000000351
name: YBR147W
def: "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family\, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog\, YPQ1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT11" EXACT []
synonym: "RTC2" EXACT []
synonym: "YPQ3" EXACT []

[Term]
id: sgd:S000000352
name: YBR148W
def: "Protein required for normal prospore membrane formation; interacts with Gip1p\, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; YSW1 has a paralog\, SPO21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSW1" EXACT []

[Term]
id: sgd:S000000353
name: YBR149W
def: "NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARA1" EXACT []
synonym: "D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1" EXACT []

[Term]
id: sgd:S000000354
name: YBR150C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog\, HAL9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TBS1" EXACT []

[Term]
id: sgd:S000000355
name: YBR151W
def: "Protein of unknown function; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APD1" EXACT []

[Term]
id: sgd:S000000356
name: YBR152W
def: "mRNA splicing factor\, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPP381" EXACT []

[Term]
id: sgd:S000000357
name: YBR153W
def: "Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIB7" EXACT []

[Term]
id: sgd:S000000358
name: YBR154C
def: "RNA polymerase subunit ABC27; common to RNA polymerases I\, II\, and III; contacts DNA and affects transactivation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC27" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPB5" EXACT []
synonym: "RPB5" EXACT []

[Term]
id: sgd:S000000359
name: YBR155W
def: "TPR-containing co-chaperone; binds both Hsp82p \(Hsp90\) and Ssa1p \(Hsp70\) and stimulates the ATPase activity of SSA1\, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNS1" EXACT []

[Term]
id: sgd:S000000360
name: YBR156C
def: "Subunit of the conserved chromosomal passenger complex \(CPC\); complex regulates kinetochore-microtubule attachments\, activation of the spindle tension checkpoint\, and mitotic spindle disassembly; other complex members are Ipl1p\, Bir1p\, and Nbl1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLI15" EXACT []

[Term]
id: sgd:S000000361
name: YBR157C
def: "Protein of unknown function; null mutation does not confer any obvious defects in growth\, spore germination\, viability\, or carbohydrate utilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICS2" EXACT []

[Term]
id: sgd:S000000362
name: YBR158W
def: "Protein required for daughter cell separation; multiple mitotic checkpoints\, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network \(MEN\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMN1" EXACT []
synonym: "CST13" EXACT []
synonym: "ICS4" EXACT []

[Term]
id: sgd:S000000363
name: YBR159W
def: "Microsomal beta-keto-reductase; contains oleate response element \(ORE\) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis\, accumulate high levels of dihydrosphingosine\, phytosphingosine and medium-chain ceramides" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IFA38" EXACT []
synonym: "ketoreductase" EXACT []

[Term]
id: sgd:S000000364
name: YBR160W
def: "Cyclin-dependent kinase \(CDK\) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1 \(CLNs\)\, S and G2/M \(CLBs\) phase cyclins\, which provide substrate specificity; regulates cell cycle and basal transcription\, chromosome duplication and segregation\, lipid biosynthesis\, membrane trafficking\, polarized growth\, and morphogenesis; abundance increases in DNA replication stress; transcript induction in osmostress involves antisense RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC28" EXACT []
synonym: "CDK1" EXACT []
synonym: "HSL5" EXACT []
synonym: "SRM5" EXACT []
synonym: "cyclin-dependent serine/threonine-protein kinase CDC28" EXACT []

[Term]
id: sgd:S000000365
name: YBR161W
def: "Mannosylinositol phosphorylceramide \(MIPC\) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog\, SUR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSH1" EXACT []
synonym: "mannosylinositol phosphorylceramide synthase catalytic subunit CSH1" EXACT []

[Term]
id: sgd:S000000366
name: YBR162C
def: "Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1\,3-glucanase; has sequence similarity to YJL171C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS1" EXACT []

[Term]
id: sgd:S000000367
name: YBR163W
def: "Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEM1" EXACT []
synonym: "EXO5" EXACT []

[Term]
id: sgd:S000000368
name: YBR164C
def: "Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; G protein of the Ras superfamily\, similar to ADP-ribosylation factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARL1" EXACT []
synonym: "Arf family GTPase ARL1" EXACT []
synonym: "DLP2" EXACT []

[Term]
id: sgd:S000000369
name: YBR165W
def: "Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBS1" EXACT []

[Term]
id: sgd:S000000370
name: YBR166C
def: "Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TYR1" EXACT []
synonym: "pprephenate dehydrogenase (NADP(+))" EXACT []

[Term]
id: sgd:S000000371
name: YBR167C
def: "Subunit of both RNase MRP and nuclear RNase P; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP7" EXACT []
synonym: "RPP2" EXACT []

[Term]
id: sgd:S000000372
name: YBR168W
def: "Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX32" EXACT []

[Term]
id: sgd:S000000373
name: YBR169C
def: "Member of the heat shock protein 70 \(HSP70\) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog\, SSE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSE2" EXACT []
synonym: "adenyl-nucleotide exchange factor SSE2" EXACT []

[Term]
id: sgd:S000000374
name: YBR170C
def: "Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded\, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins\, such as HMG-CoA reductase \(Hmg1/2p\) and cytoplasmic proteins \(Fbp1p\); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing \(RUP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRD4" EXACT []
synonym: "NPL4" EXACT []

[Term]
id: sgd:S000000375
name: YBR171W
def: "Non-essential subunit of Sec63 complex; with Sec61 complex\, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p\, Sec62p\, and Sec72p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSS1" EXACT []
synonym: "SEC66" EXACT []
synonym: "SEC71" EXACT []
synonym: "Sec63 complex subunit SEC66" EXACT []

[Term]
id: sgd:S000000376
name: YBR172C
def: "GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog\, SYH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMY2" EXACT []

[Term]
id: sgd:S000000377
name: YBR173C
def: "Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNS2" EXACT []
synonym: "UMP1" EXACT []

[Term]
id: sgd:S000000378
name: YBR174C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000379
name: YBR175W
def: "Essential subunit of the COMPASS \(Set1C\) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS30" EXACT []
synonym: "SAF35" EXACT []
synonym: "SWD3" EXACT []

[Term]
id: sgd:S000000380
name: YBR176W
def: "Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis\, converts 2-oxoisovalerate into 2-dehydropantoate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-methyl-2-oxobutanoate hydroxymethyltransferase" EXACT []
synonym: "ECM31" EXACT []

[Term]
id: sgd:S000000381
name: YBR177C
def: "Acyl-coenzymeA\:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog\, EEB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EHT1" EXACT []

[Term]
id: sgd:S000000382
name: YBR178W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000383
name: YBR179C
def: "Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FZO1" EXACT []
synonym: "mitofusin" EXACT []

[Term]
id: sgd:S000000384
name: YBR180W
def: "Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3\, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DTR1" EXACT []

[Term]
id: sgd:S000000385
name: YBR181C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S6\, no bacterial homolog; RPS6B has a paralog\, RPS6A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPG18" EXACT []
synonym: "RPS101" EXACT []
synonym: "RPS102" EXACT []
synonym: "RPS6B" EXACT []
synonym: "S6e" EXACT []
synonym: "ribosomal 40S subunit protein S6B" EXACT []

[Term]
id: sgd:S000000386
name: YBR182C
def: "MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog\, RLM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMP1" EXACT []

[Term]
id: sgd:S000000387
name: YBR183W
def: "Alkaline ceramidase; also has reverse \(CoA-independent\) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog\, YDC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPC1" EXACT []
synonym: "phytoceramidase" EXACT []

[Term]
id: sgd:S000000388
name: YBR184W
def: "Putative protein of unknown function; YBR184W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000389
name: YBR185C
def: "Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MBA1" EXACT []

[Term]
id: sgd:S000000390
name: YBR186W
def: "Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint\, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCH2" EXACT []

[Term]
id: sgd:S000000391
name: YBR187W
def: "Protein of unknown function involved in calcium homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion protein localizes to the vacuole; TMEM165\, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDT1" EXACT []

[Term]
id: sgd:S000000392
name: YBR188C
def: "Member of the NineTeen Complex \(NTC\); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTC20" EXACT []

[Term]
id: sgd:S000000393
name: YBR189W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog\, RPS9A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS13A" EXACT []
synonym: "RPS9B" EXACT []
synonym: "S13" EXACT []
synonym: "S4" EXACT []
synonym: "S9B" EXACT []
synonym: "SUP46" EXACT []
synonym: "YS11" EXACT []
synonym: "ribosomal 40S subunit protein S9B" EXACT []
synonym: "rp21" EXACT []

[Term]
id: sgd:S000000394
name: YBR190W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000395
name: YBR191W
def: "Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21\, no bacterial homolog; RPL21A has a paralog\, RPL21B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L21A" EXACT []
synonym: "L21e" EXACT []
synonym: "RPL21A" EXACT []
synonym: "URP1" EXACT []
synonym: "ribosomal 60S subunit protein L21A" EXACT []

[Term]
id: sgd:S000000396
name: YBR192W
def: "Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PYT1" EXACT []
synonym: "RIM2" EXACT []

[Term]
id: sgd:S000000397
name: YBR193C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED8" EXACT []

[Term]
id: sgd:S000000398
name: YBR194W
def: "Protein proposed to be associated with the nuclear pore complex; null mutant is viable\, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM4" EXACT []
synonym: "SOY1" EXACT []

[Term]
id: sgd:S000000399
name: YBR195C
def: "Subunit of chromatin assembly factor I \(CAF-1\); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres\, mating type loci\, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAC3" EXACT []
synonym: "MSI1" EXACT []

[Term]
id: sgd:S000000400
name: YBR196C
def: "Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC30" EXACT []
synonym: "PGI1" EXACT []
synonym: "glucose-6-phosphate isomerase" EXACT []

[Term]
id: sgd:S000000401
name: YBR197C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog\, YPL077C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000402
name: YBR198C
def: "Subunit \(90 kDa\) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF5" EXACT []
synonym: "TAF90" EXACT []
synonym: "TafII90" EXACT []

[Term]
id: sgd:S000000403
name: YBR199W
def: "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus\, a membrane-spanning region and a highly conserved catalytic lumenal domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR4" EXACT []

[Term]
id: sgd:S000000404
name: YBR200W
def: "Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p\, Ste5p\, Ste20p\, and Rsr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEM1" EXACT []
synonym: "SRO1" EXACT []
synonym: "phosphatidylinositol-3-phosphate-binding protein BEM1" EXACT []

[Term]
id: sgd:S000000405
name: YBR201W
def: "ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into the ER membrane and routing them to Hrd1p for ubiquitylation; N- and C- termini protrude into the cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DER1" EXACT []

[Term]
id: sgd:S000000406
name: YBR202W
def: "Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC47" EXACT []
synonym: "MCM7" EXACT []
synonym: "mini-chromosome maintenance complex protein 7" EXACT []

[Term]
id: sgd:S000000407
name: YBR203W
def: "Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS111" EXACT []

[Term]
id: sgd:S000000408
name: YBR204C
def: "Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis\, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet \(LD\) surface; contains a classical serine containing catalytic triad \(GxSxG motif\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDH1" EXACT []

[Term]
id: sgd:S000000409
name: YBR205W
def: "Putative alpha-1\,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR3" EXACT []
synonym: "mannosyltransferase KTR3" EXACT []

[Term]
id: sgd:S000000410
name: YBR206W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000411
name: YBR207W
def: "Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FTH1" EXACT []

[Term]
id: sgd:S000000412
name: YBR208C
def: "Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities\, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate\, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUR1,2" EXACT []
synonym: "DUR80" EXACT []
synonym: "bifunctional urea carboxylase/allophanate hydrolase" EXACT []

[Term]
id: sgd:S000000413
name: YBR209W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YBR209W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000414
name: YBR210W
def: "Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog\, ERV14\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV15" EXACT []

[Term]
id: sgd:S000000415
name: YBR211C
def: "Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA \(Ctf19p\, Okp1p\, Mcm21p\, Ame1p\); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AME1" EXACT []
synonym: "ARP100" EXACT []

[Term]
id: sgd:S000000416
name: YBR212W
def: "RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin \(POR1\) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NGR1" EXACT []
synonym: "RBP1" EXACT []

[Term]
id: sgd:S000000417
name: YBR213W
def: "Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme\, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET8" EXACT []
synonym: "bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8" EXACT []

[Term]
id: sgd:S000000418
name: YBR214W
def: "Protein involved in cell separation during budding; one of two S. cerevisiae homologs \(Sds23p and Sds24p\) of the S. pombe Sds23 protein\, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog\, SDS23\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDS24" EXACT []

[Term]
id: sgd:S000000419
name: YBR215W
def: "Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT\, a complex that allows passage of RNA Pol II through nucleosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPC2" EXACT []

[Term]
id: sgd:S000000420
name: YBR216C
def: "Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p\, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog\, YBP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YBP1" EXACT []

[Term]
id: sgd:S000000421
name: YBR217W
def: "Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p cojugate also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG12" EXACT []
synonym: "ATG12" EXACT []

[Term]
id: sgd:S000000422
name: YBR218C
def: "Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog\, PYC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PYC2" EXACT []
synonym: "pyruvate carboxylase 2" EXACT []

[Term]
id: sgd:S000000423
name: YBR219C
def: "Putative protein of unknown function; YBR219C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000424
name: YBR220C
def: "Putative protein of unknown function; YBR220C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000425
name: YBR221C
def: "E1 beta subunit of the pyruvate dehydrogenase \(PDH\) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDB1" EXACT []
synonym: "pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta" EXACT []

[Term]
id: sgd:S000000426
name: YBR222C
def: "Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix\, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAT2" EXACT []
synonym: "PCS60" EXACT []

[Term]
id: sgd:S000000427
name: YBR223C
def: "Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDP1" EXACT []
synonym: "tyrosyl-DNA phosphodiesterase 1" EXACT []

[Term]
id: sgd:S000000428
name: YBR224W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000429
name: YBR225W
def: "Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000430
name: YBR226C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000431
name: YBR227C
def: "Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCX1" EXACT []

[Term]
id: sgd:S000000432
name: YBR228W
def: "Endonuclease involved in DNA recombination and repair; subunit of a complex\, with Slx4p\, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLX1" EXACT []

[Term]
id: sgd:S000000433
name: YBR229C
def: "Glucosidase II catalytic subunit; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations\, and are synthetically lethal with rot1 mutations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-alpha-glucosidase ROT2" EXACT []
synonym: "GLS2" EXACT []
synonym: "ROT2" EXACT []
synonym: "glucan 1" EXACT []

[Term]
id: sgd:S000000434
name: YBR230C
def: "Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex \(NAC\) bound to ribosomes\, contributing to co-translational mitochondrial import; interacts with porin \(Por1p\) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OM14" EXACT []

[Term]
id: sgd:S000000435
name: YBR231C
def: "Component of the SWR1 complex; complex exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AOR1" EXACT []
synonym: "SWC5" EXACT []

[Term]
id: sgd:S000000436
name: YBR232C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000437
name: YBR233W
def: "RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein\, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEK1" EXACT []
synonym: "PBP2" EXACT []

[Term]
id: sgd:S000000438
name: YBR234C
def: "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC40" EXACT []

[Term]
id: sgd:S000000439
name: YBR235W
def: "Vacuolar membrane cation-chloride cotransporter \(CCC\); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na\(+\)-\(K+\)-C1- cotransporter family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHC1" EXACT []

[Term]
id: sgd:S000000440
name: YBR236C
def: "Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABD1" EXACT []

[Term]
id: sgd:S000000441
name: YBR237W
def: "RNA helicase in the DEAD-box family; necessary for prespliceosome formation\, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAD-box RNA helicase PRP5" EXACT []
synonym: "PRP5" EXACT []
synonym: "RNA5" EXACT []

[Term]
id: sgd:S000000442
name: YBR238C
def: "Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog\, RMD9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000443
name: YBR239C
def: "Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm\, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins\, similar to Rds2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERT1" EXACT []

[Term]
id: sgd:S000000444
name: YBR240C
def: "Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand\, possibly as related to carbon source availability; zinc finger protein of the Zn\(II\)2Cys6 type" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO6" EXACT []
synonym: "THI2" EXACT []
synonym: "phoF" EXACT []

[Term]
id: sgd:S000000445
name: YBR241C
def: "Putative transporter\, member of the sugar porter family; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene; YBR241C has a paralog\, VPS73\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000446
name: YBR242W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene; YBR242W has a paralog\, YGL101W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000447
name: YBR243C
def: "UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALG7" EXACT []
synonym: "TUR1" EXACT []
synonym: "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" EXACT []

[Term]
id: sgd:S000000448
name: YBR244W
def: "Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMI1" EXACT []
synonym: "GPX2" EXACT []
synonym: "glutathione peroxidase GPX2" EXACT []

[Term]
id: sgd:S000000449
name: YBR245C
def: "ATPase subunit of imitation-switch \(ISWI\) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISW1" EXACT []
synonym: "SGN2" EXACT []
synonym: "chromatin-remodeling ATPase ISW1" EXACT []

[Term]
id: sgd:S000000450
name: YBR246W
def: "Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH7" EXACT []
synonym: "ERE1" EXACT []
synonym: "RRT2" EXACT []
synonym: "diphthamide synthase" EXACT []

[Term]
id: sgd:S000000451
name: YBR247C
def: "Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENP1" EXACT []
synonym: "MEG1" EXACT []

[Term]
id: sgd:S000000452
name: YBR248C
def: "Imidazole glycerol phosphate synthase; glutamine amidotransferase\:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide \(AICAR\)\, a purine precursor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIS7" EXACT []
synonym: "imidazoleglycerol-phosphate synthase" EXACT []

[Term]
id: sgd:S000000453
name: YBR249C
def: "3-deoxy-D-arabino-heptulosonate-7-phosphate \(DAHP\) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-deoxy-7-phosphoheptulonate synthase ARO4" EXACT []
synonym: "ARO4" EXACT []

[Term]
id: sgd:S000000454
name: YBR250W
def: "Protein of unknown function; associates with meiosis-specific protein Spo1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO23" EXACT []

[Term]
id: sgd:S000000455
name: YBR251W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS5" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS5" EXACT []

[Term]
id: sgd:S000000456
name: YBR252W
def: "deoxyuridine triphosphate diphosphatase \(dUTPase\); catalyzes hydrolysis of dUTP to dUMP and PPi\, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUT1" EXACT []
synonym: "bifunctional dITP/dUTP diphosphatase" EXACT []

[Term]
id: sgd:S000000457
name: YBR253W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED22" EXACT []
synonym: "SRB6" EXACT []

[Term]
id: sgd:S000000458
name: YBR254C
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\); mutation of conserved residues leads to defects in endocytic recycling and a block in sporulation/meiosis; mutations in the human homolog cause the spondyloepiphyseal dysplasia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS20" EXACT []

[Term]
id: sgd:S000000459
name: YBR255W
def: "Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC4" EXACT []

[Term]
id: sgd:S000000460
name: YBR256C
def: "Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIB5" EXACT []
synonym: "riboflavin synthase" EXACT []

[Term]
id: sgd:S000000461
name: YBR257W
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP4" EXACT []

[Term]
id: sgd:S000000462
name: YBR258C
def: "Subunit of the COMPASS \(Set1C\) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS15" EXACT []
synonym: "SHG1" EXACT []

[Term]
id: sgd:S000000463
name: YBR259W
def: "Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000464
name: YBR260C
def: "GTPase-activating protein \(RhoGAP\) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGD1" EXACT []

[Term]
id: sgd:S000000465
name: YBR261C
def: "AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTM1" EXACT []
synonym: "TAE1" EXACT []

[Term]
id: sgd:S000000466
name: YBR262C
def: "Component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM5" EXACT []
synonym: "FMP51" EXACT []
synonym: "MCS12" EXACT []
synonym: "MIC12" EXACT []

[Term]
id: sgd:S000000467
name: YBR263W
def: "Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5\,10 methylenetetrahydrofolate; involved in generating precursors for purine\, pyrimidine\, amino acid\, and lipid biosynthesis; reverse reaction generates serine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHM1" EXACT []
synonym: "SHMT1" EXACT []
synonym: "TMP3" EXACT []
synonym: "glycine hydroxymethyltransferase SHM1" EXACT []

[Term]
id: sgd:S000000468
name: YBR264C
def: "Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT10" EXACT []
synonym: "YPT10" EXACT []

[Term]
id: sgd:S000000469
name: YBR265W
def: "3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-dehydrosphinganine reductase" EXACT []
synonym: "TSC10" EXACT []

[Term]
id: sgd:S000000470
name: YBR266C
def: "Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLM6" EXACT []

[Term]
id: sgd:S000000471
name: YBR267W
def: "Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1\, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REI1" EXACT []

[Term]
id: sgd:S000000472
name: YBR268W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL37" EXACT []
synonym: "YmL37" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL37" EXACT []

[Term]
id: sgd:S000000473
name: YBR269C
def: "Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p\, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP21" EXACT []
synonym: "SDH8" EXACT []

[Term]
id: sgd:S000000474
name: YBR270C
def: "Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p\, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog\, BIT61\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIT2" EXACT []

[Term]
id: sgd:S000000475
name: YBR271W
def: "S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 \(Eft1p and Eft2p\) at lysine 613 and methylates EF3 \(Yef3p\) at lysine 187; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFM2" EXACT []

[Term]
id: sgd:S000000476
name: YBR272C
def: "Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle \(RP\); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSM3" EXACT []

[Term]
id: sgd:S000000477
name: YBR273C
def: "UBX \(ubiquitin regulatory X\) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog\, UBX6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUI3" EXACT []
synonym: "UBX7" EXACT []

[Term]
id: sgd:S000000478
name: YBR274W
def: "Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHK1" EXACT []
synonym: "serine/threonine protein kinase CHK1" EXACT []

[Term]
id: sgd:S000000479
name: YBR275C
def: "Protein that binds to the Rap1p C-terminus; acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; contributes to resection of DNA double strand breaks \(DSBs\); deletion results in telomere elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding protein RIF1" EXACT []
synonym: "RIF1" EXACT []

[Term]
id: sgd:S000000480
name: YBR276C
def: "Protein phosphatase; has specificity for serine\, threonine\, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPS1" EXACT []
synonym: "tyrosine/serine/threonine protein phosphatase PPS1" EXACT []

[Term]
id: sgd:S000000481
name: YBR277C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000482
name: YBR278W
def: "Third-largest subunit of DNA polymerase II \(DNA polymerase epsilon\); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA\, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog\, DLS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPB3" EXACT []

[Term]
id: sgd:S000000483
name: YBR279W
def: "Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes\, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAF1" EXACT []

[Term]
id: sgd:S000000484
name: YBR280C
def: "F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAF1" EXACT []
synonym: "SCF ubiquitin ligase complex subunit SAF1" EXACT []

[Term]
id: sgd:S000000485
name: YBR281C
def: "Component of glutamine amidotransferase \(GATase II\); forms a complex with Dug3p to degrade glutathione \(GSH\) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase \(Ecm38p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUG2" EXACT []
synonym: "glutamine amidotransferase subunit DUG2" EXACT []

[Term]
id: sgd:S000000486
name: YBR282W
def: "Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL27" EXACT []
synonym: "YmL27" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL27" EXACT []

[Term]
id: sgd:S000000487
name: YBR283C
def: "Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSH1" EXACT []

[Term]
id: sgd:S000000488
name: YBR284W
def: "Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres\, altered Ty mobility\, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog\, YJL070C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "metallo-dependent hydrolase superfamily protein" EXACT []

[Term]
id: sgd:S000000489
name: YBR285W
def: "Putative protein of unknown function; YBR285W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000490
name: YBR286W
def: "Vacuolar aminopeptidase Y; processed to mature form by Prb1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APE3" EXACT []
synonym: "APY1" EXACT []

[Term]
id: sgd:S000000491
name: YBR287W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the ER; YBR287W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZSP1" EXACT []

[Term]
id: sgd:S000000492
name: YBR288C
def: "Mu3-like subunit of the clathrin associated protein complex \(AP-3\); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APM3" EXACT []
synonym: "YKS6" EXACT []

[Term]
id: sgd:S000000493
name: YBR289W
def: "Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAF4" EXACT []
synonym: "SNF5" EXACT []
synonym: "SWI10" EXACT []
synonym: "TYE4" EXACT []

[Term]
id: sgd:S000000494
name: YBR290W
def: "Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport\, prevents metal hyperaccumulation\, functions in copper detoxification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSD2" EXACT []

[Term]
id: sgd:S000000495
name: YBR291C
def: "Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTP1" EXACT []

[Term]
id: sgd:S000000496
name: YBR292C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YBR292C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000497
name: YBR293W
def: "Permease of basic amino acids in the vacuolar membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VBA2" EXACT []

[Term]
id: sgd:S000000498
name: YBR294W
def: "High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p\, which control the concentration of endogenous activated sulfate intermediates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFP2" EXACT []
synonym: "SUL1" EXACT []

[Term]
id: sgd:S000000499
name: YBR295W
def: "Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding\, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAD2" EXACT []
synonym: "PAY2" EXACT []
synonym: "PCA1" EXACT []
synonym: "cation-transporting P-type ATPase PCA1" EXACT []

[Term]
id: sgd:S000000500
name: YBR296C
def: "Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ITN1" EXACT []
synonym: "PHO89" EXACT []

[Term]
id: sgd:S000000501
name: YBR297W
def: "MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAL33" EXACT []
synonym: "MAL3R" EXACT []
synonym: "MALR" EXACT []
synonym: "transcription factor MAL33" EXACT []

[Term]
id: sgd:S000000502
name: YBR298C
def: "Maltose permease; high-affinity maltose transporter \(alpha-glucoside transporter\); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAL31" EXACT []
synonym: "MAL3T" EXACT []
synonym: "MALT" EXACT []

[Term]
id: sgd:S000000503
name: YBR299W
def: "Maltase \(alpha-D-glucosidase\); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose\, turanose\, maltotriose\, and sucrose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAL32" EXACT []
synonym: "MAL3S" EXACT []
synonym: "MALS" EXACT []
synonym: "alpha-glucosidase MAL32" EXACT []

[Term]
id: sgd:S000000504
name: YBR300C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000505
name: YBR301W
def: "Cell wall mannoprotein; has similarity to Tir1p\, Tir2p\, Tir3p\, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions\, completely repressed during aerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAN3" EXACT []
synonym: "PAU24" EXACT []
synonym: "seripauperin PAU24" EXACT []

[Term]
id: sgd:S000000506
name: YBR302C
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS2" EXACT []

[Term]
id: sgd:S000000507
name: YCL001W
def: "Protein involved in retention of membrane proteins; including Sec12p\, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RER1" EXACT []

[Term]
id: sgd:S000000508
name: YCL002C
def: "Putative protein of unknown function; YCL002C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000510
name: YCL004W
def: "Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" EXACT []
synonym: "PEL1" EXACT []
synonym: "PGS1" EXACT []
synonym: "YCL003W" EXACT []

[Term]
id: sgd:S000000511
name: YCL005W
def: "Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB16" EXACT []

[Term]
id: sgd:S000000513
name: YCL007C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white\, but this phenotype was later shown to be due to the defect in YCL005W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH36" EXACT []

[Term]
id: sgd:S000000514
name: YCL008C
def: "Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p\, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGS1" EXACT []
synonym: "STP22" EXACT []
synonym: "VPL15" EXACT []
synonym: "VPS23" EXACT []
synonym: "ubiquitin-binding ESCRT-I subunit protein STP22" EXACT []

[Term]
id: sgd:S000000515
name: YCL009C
def: "Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit\, localizes to mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILV6" EXACT []
synonym: "acetolactate synthase regulatory subunit" EXACT []

[Term]
id: sgd:S000000516
name: YCL010C
def: "Component of the HAT/Core module of the SAGA\, SLIK\, and ADA complexes; HAT/Core module also contains Gcn5p\, Ngg1p\, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGF29" EXACT []

[Term]
id: sgd:S000000517
name: YCL011C
def: "Poly\(A+\) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog\, HRB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GBP2" EXACT []
synonym: "RLF6" EXACT []

[Term]
id: sgd:S000000520
name: YCL014W
def: "Protein involved in bud-site selection; required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD3" EXACT []
synonym: "YCL012W" EXACT []

[Term]
id: sgd:S000000521
name: YCL016C
def: "Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCC1" EXACT []

[Term]
id: sgd:S000000522
name: YCL017C
def: "Cysteine desulfurase; involved in iron-sulfur cluster \(Fe/S\) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NFS1" EXACT []
synonym: "SPL1" EXACT []

[Term]
id: sgd:S000000523
name: YCL018W
def: "Beta-isopropylmalate dehydrogenase \(IMDH\); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of β-ethylmalate into α-ketovalerate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-isopropylmalate dehydrogenase" EXACT []
synonym: "LEU2" EXACT []

[Term]
id: sgd:S000000527
name: YCL022C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000528
name: YCL023C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000529
name: YCL024W
def: "Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins\, negatively regulates Swe1p by phosphorylation\, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog\, GIN4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KCC4" EXACT []

[Term]
id: sgd:S000000530
name: YCL025C
def: "Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine\, glutamine\, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system \(Ssy1p-Ptr3p-Ssy5p\); AGP1 has a paralog\, GNP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGP1" EXACT []
synonym: "YCC5" EXACT []
synonym: "amino acid transporter AGP1" EXACT []

[Term]
id: sgd:S000000532
name: YCL027W
def: "Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling\, fusion\, and polarization events required for fusion; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUS1" EXACT []

[Term]
id: sgd:S000000533
name: YCL028W
def: "\[PIN\(+\)\] prion; an infectious protein conformation that is generally an ordered protein aggregate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNQ1" EXACT []
synonym: "[PIN(+)]" EXACT []
synonym: "prion domain-containing protein RNQ1" EXACT []

[Term]
id: sgd:S000000534
name: YCL029C
def: "Microtubule-associated protein; component of the interface between microtubules and kinetochore\, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARM5" EXACT []
synonym: "BIK1" EXACT []
synonym: "PAC14" EXACT []

[Term]
id: sgd:S000000535
name: YCL030C
def: "Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase\, and histidinol dehydrogenase activities; catalyzes the second\, third\, ninth and tenth steps in histidine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIS4" EXACT []
synonym: "trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase" EXACT []

[Term]
id: sgd:S000000536
name: YCL031C
def: "Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP7" EXACT []

[Term]
id: sgd:S000000537
name: YCL032W
def: "Adaptor protein for various signaling pathways; involved in mating response\, invasive/filamentous growth\, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE50" EXACT []

[Term]
id: sgd:S000000538
name: YCL033C
def: "Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSRB" EXACT []
synonym: "MXR2" EXACT []

[Term]
id: sgd:S000000539
name: YCL034W
def: "Protein of unknown function; binds Las17p\, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSB5" EXACT []

[Term]
id: sgd:S000000540
name: YCL035C
def: "Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive\, heat-stable\, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog\, GRX2\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX1" EXACT []
synonym: "dithiol glutaredoxin GRX1" EXACT []

[Term]
id: sgd:S000000541
name: YCL036W
def: "Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog\, YDR514C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GFD2" EXACT []
synonym: "YCD6" EXACT []

[Term]
id: sgd:S000000542
name: YCL037C
def: "Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex\, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog\, SLF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRO9" EXACT []

[Term]
id: sgd:S000000543
name: YCL038C
def: "Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG22" EXACT []
synonym: "AUT4" EXACT []

[Term]
id: sgd:S000000544
name: YCL039W
def: "Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1\,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID7" EXACT []
synonym: "MOH2" EXACT []
synonym: "glucose-induced degradation complex subunit GID7" EXACT []

[Term]
id: sgd:S000000545
name: YCL040W
def: "Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog\, EMI2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLK1" EXACT []
synonym: "HOR3" EXACT []
synonym: "glucokinase" EXACT []

[Term]
id: sgd:S000000546
name: YCL041C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000547
name: YCL042W
def: "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000548
name: YCL043C
def: "Protein disulfide isomerase; multifunctional protein of ER lumen\, essential for formation of disulfide bonds in secretory and cell-surface proteins\, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity\, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2\, promoting degradation in unfolded protein response; PDI1 has a paralog\, EUG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFP1" EXACT []
synonym: "PDI1" EXACT []
synonym: "TRG1" EXACT []
synonym: "protein disulfide isomerase PDI1" EXACT []

[Term]
id: sgd:S000000549
name: YCL044C
def: "Subunit of the mitochondrial \(mt\) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGR1" EXACT []

[Term]
id: sgd:S000000550
name: YCL045C
def: "Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1\, fly CG2943\, and human KIAA0090" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMC1" EXACT []

[Term]
id: sgd:S000000551
name: YCL046W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000552
name: YCL047C
def: "Nicotinamide mononucleotide-specific adenylyltransferase \(NMNAT\); catalyzes the conversion of nicotinamide mononucleotide \(NMN\) to nicotinamide adenine dinucleotide \(NAD+\); role in the nicotinamide riboside \(NR\) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POF1" EXACT []

[Term]
id: sgd:S000000553
name: YCL048W
def: "Protein of unknown function; SPS22 has a paralog\, SPS2\, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS22" EXACT []

[Term]
id: sgd:S000000554
name: YCL049C
def: "Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000555
name: YCL050C
def: "AP4A phosphorylase; bifunctional diadenosine 5'\,5'''-P1\,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis\(5'-nucleosidyl\) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates\, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog\, APA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APA1" EXACT []
synonym: "DTP1" EXACT []

[Term]
id: sgd:S000000556
name: YCL051W
def: "Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related \(NDR\) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog\, HLR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LRE1" EXACT []

[Term]
id: sgd:S000000557
name: YCL052C
def: "Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBN1" EXACT []

[Term]
id: sgd:S000000559
name: YCL054W
def: "AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52\, U2921; suppressor of PAB1 mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPB1" EXACT []

[Term]
id: sgd:S000000560
name: YCL055W
def: "Transcription factor required for response to pheromones; also required during meiosis; exists in two forms\, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAR4" EXACT []

[Term]
id: sgd:S000000561
name: YCL056C
def: "Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p\, Pex25p\, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX34" EXACT []

[Term]
id: sgd:S000000562
name: YCL057W
def: "Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p\, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRD1" EXACT []

[Term]
id: sgd:S000000563
name: YCL058C
def: "Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV5" EXACT []
synonym: "MDF1" EXACT []

[Term]
id: sgd:S000000564
name: YCL059C
def: "Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRR1" EXACT []

[Term]
id: sgd:S000000566
name: YCL061C
def: "S-phase checkpoint protein required for DNA replication; couples DNA helicase and DNA polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress\, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; with Hog1p defines a novel S-phase checkpoint that permits eukaryotic cells to prevent conflicts between DNA replication and transcription; protects uncapped telomeres; degradation via Dia2p help cells resume cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRC1" EXACT []
synonym: "YCL060C" EXACT []
synonym: "chromatin-modulating protein MRC1" EXACT []

[Term]
id: sgd:S000000568
name: YCL063W
def: "Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAC17" EXACT []
synonym: "YCL062W" EXACT []

[Term]
id: sgd:S000000569
name: YCL064C
def: "Catabolic L-serine \(L-threonine\) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source\, transcriptionally induced by serine and threonine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHA1" EXACT []
synonym: "L-serine/L-threonine ammonia-lyase CHA1" EXACT []

[Term]
id: sgd:S000000570
name: YCL065W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps HMLALPHA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000571
name: YCL066W
def: "Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALPHA1" EXACT []
synonym: "HMLALPHA1" EXACT []

[Term]
id: sgd:S000000572
name: YCL067C
def: "Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALPHA2" EXACT []
synonym: "HMLALPHA2" EXACT []

[Term]
id: sgd:S000000573
name: YCL068C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000574
name: YCL069W
def: "Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog\, VBA5\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VBA3" EXACT []

[Term]
id: sgd:S000000575
name: YCL073C
def: "Proton\:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog\, GEX2\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEX1" EXACT []

[Term]
id: sgd:S000000581
name: YCL076W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000589
name: YCL026C-A
def: "Type II nitroreductase\, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRM2" EXACT []
synonym: "YCLX08C" EXACT []

[Term]
id: sgd:S000000594
name: YCR001W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YCR001W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000595
name: YCR002C
def: "Component of the septin ring\, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4\,5-bisphosphate; protein abundance increases under DNA damage stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC10" EXACT []
synonym: "septin CDC10" EXACT []

[Term]
id: sgd:S000000596
name: YCR003W
def: "Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL32" EXACT []
synonym: "YmL32" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL32" EXACT []

[Term]
id: sgd:S000000597
name: YCR004C
def: "Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCP4" EXACT []

[Term]
id: sgd:S000000598
name: YCR005C
def: "Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate\, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog\, CIT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIT2" EXACT []
synonym: "citrate (Si)-synthase CIT2" EXACT []

[Term]
id: sgd:S000000599
name: YCR006C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000600
name: YCR007C
def: "Putative integral membrane protein; member of DUP240 gene family; YCR007C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein" EXACT []

[Term]
id: sgd:S000000601
name: YCR008W
def: "Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p\, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL4" EXACT []
synonym: "SAT4" EXACT []
synonym: "serine/threonine protein kinase SAT4" EXACT []

[Term]
id: sgd:S000000602
name: YCR009C
def: "Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton\, endocytosis\, cell polarity\, cell fusion and viability following starvation or osmotic stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END6" EXACT []
synonym: "FUS7" EXACT []
synonym: "RVS161" EXACT []
synonym: "SPE161" EXACT []
synonym: "amphiphysin-like protein RVS161" EXACT []

[Term]
id: sgd:S000000603
name: YCR010C
def: "Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog\, ATO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADY2" EXACT []
synonym: "ATO1" EXACT []

[Term]
id: sgd:S000000604
name: YCR011C
def: "Putative ATP-dependent permease of the ABC transporter family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADP1" EXACT []
synonym: "putative ATP-dependent permease ADP1" EXACT []

[Term]
id: sgd:S000000605
name: YCR012W
def: "3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1\,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGK1" EXACT []
synonym: "phosphoglycerate kinase" EXACT []

[Term]
id: sgd:S000000606
name: YCR013C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000607
name: YCR014C
def: "DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining \(NHEJ\); homologous to mammalian DNA polymerase beta" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POL4" EXACT []
synonym: "POLX" EXACT []

[Term]
id: sgd:S000000608
name: YCR015C
def: "Putative protein of unknown function; YCR015C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000609
name: YCR016W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000610
name: YCR017C
def: "Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH43" EXACT []

[Term]
id: sgd:S000000611
name: YCR018C
def: "Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRD1" EXACT []

[Term]
id: sgd:S000000612
name: YCR019W
def: "Protein necessary for stability of L-A dsRNA-containing particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK32" EXACT []

[Term]
id: sgd:S000000613
name: YCR020C
def: "Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIT2" EXACT []
synonym: "PET18" EXACT []

[Term]
id: sgd:S000000614
name: YCR020C-A
def: "Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM9" EXACT []
synonym: "MAK31" EXACT []
synonym: "NAA38" EXACT []
synonym: "SMX1" EXACT []

[Term]
id: sgd:S000000615
name: YCR021C
def: "Negative regulator of the H\(+\)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock\, ethanol treatment\, weak organic acid\, glucose limitation\, and entry into stationary phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP30" EXACT []
synonym: "YRO1" EXACT []

[Term]
id: sgd:S000000616
name: YCR022C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YCR022C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000617
name: YCR023C
def: "Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000618
name: YCR024C
def: "Mitochondrial asparaginyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLM5" EXACT []
synonym: "asparagine--tRNA ligase SLM5" EXACT []

[Term]
id: sgd:S000000619
name: YCR024C-A
def: "Regulatory subunit for the plasma membrane H\(+\)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog\, PMP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMP1" EXACT []

[Term]
id: sgd:S000000620
name: YCR025C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YCR025C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000621
name: YCR026C
def: "Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog\, NPP2\, that arose from the whole genome duplication\, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPP1" EXACT []

[Term]
id: sgd:S000000622
name: YCR027C
def: "Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHB1" EXACT []
synonym: "RSG1" EXACT []
synonym: "putative GTPase RHB1" EXACT []

[Term]
id: sgd:S000000623
name: YCR028C
def: "Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FEN2" EXACT []

[Term]
id: sgd:S000000626
name: YCR030C
def: "Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYP1" EXACT []
synonym: "YCR029C-A" EXACT []

[Term]
id: sgd:S000000627
name: YCR031C
def: "Protein component of the small \(40S\) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog\, RPS14B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRY1" EXACT []
synonym: "RPL59" EXACT []
synonym: "RPS14A" EXACT []
synonym: "S11" EXACT []
synonym: "S14A" EXACT []
synonym: "ribosomal 40S subunit protein S14A" EXACT []
synonym: "rp59A" EXACT []

[Term]
id: sgd:S000000628
name: YCR032W
def: "Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse\, respectively\, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BPH1" EXACT []

[Term]
id: sgd:S000000629
name: YCR033W
def: "Subunit of the Set3C deacetylase complex; interacts directly with the Set3C subunit\, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNT1" EXACT []

[Term]
id: sgd:S000000630
name: YCR034W
def: "Fatty acid elongase\, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1\,3-beta-glucan synthase\, vacuolar ATPase\, and the secretory pathway; ELO2 has a paralog\, ELO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELO2" EXACT []
synonym: "FEN1" EXACT []
synonym: "GNS1" EXACT []
synonym: "VBM2" EXACT []
synonym: "fatty acid elongase ELO2" EXACT []

[Term]
id: sgd:S000000631
name: YCR035C
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p \(OIP2\, EXOSC8\); protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP43" EXACT []

[Term]
id: sgd:S000000632
name: YCR036W
def: "Putative ribokinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBK1" EXACT []

[Term]
id: sgd:S000000633
name: YCR037C
def: "Low-affinity inorganic phosphate \(Pi\) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog\, PHO90\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO87" EXACT []

[Term]
id: sgd:S000000634
name: YCR038C
def: "GTP/GDP exchange factor for Rsr1p \(Bud1p\); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD5" EXACT []
synonym: "Ras family guanine nucleotide exchange factor BUD5" EXACT []

[Term]
id: sgd:S000000635
name: YCR039C
def: "Homeobox-domain protein; with Mcm1p\, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALPHA2" EXACT []
synonym: "MATALPHA2" EXACT []

[Term]
id: sgd:S000000636
name: YCR040W
def: "Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALPHA1" EXACT []
synonym: "MATALPHA1" EXACT []

[Term]
id: sgd:S000000637
name: YCR041W
def: "Uncharacterized open reading frame; overexpression suppresses the high-frequency loss of mini-chromosomes\, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W\, but not its transcript\, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000638
name: YCR042C
def: "TFIID subunit \(150 kDa\); involved in RNA polymerase II transcription initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF150" EXACT []
synonym: "TAF2" EXACT []
synonym: "TSM1" EXACT []
synonym: "TafII150" EXACT []

[Term]
id: sgd:S000000639
name: YCR043C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000640
name: YCR044C
def: "Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS16" EXACT []
synonym: "PER1" EXACT []

[Term]
id: sgd:S000000641
name: YCR045C
def: "Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSW3" EXACT []
synonym: "RRT12" EXACT []

[Term]
id: sgd:S000000642
name: YCR046C
def: "Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMG1" EXACT []
synonym: "mitochondrial 54S ribosomal protein IMG1" EXACT []

[Term]
id: sgd:S000000643
name: YCR047C
def: "Methyltransferase; methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD23" EXACT []

[Term]
id: sgd:S000000644
name: YCR048W
def: "Acyl-CoA\:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog\, ARE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARE1" EXACT []
synonym: "SAT2" EXACT []

[Term]
id: sgd:S000000645
name: YCR049C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000646
name: YCR050C
def: "Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000647
name: YCR051W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin \(Ank\) repeats; YCR051W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000648
name: YCR052W
def: "Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog\, SNF12\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC6" EXACT []

[Term]
id: sgd:S000000649
name: YCR053W
def: "Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THR4" EXACT []
synonym: "threonine synthase THR4" EXACT []

[Term]
id: sgd:S000000650
name: YCR054C
def: "Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10\, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTR86" EXACT []

[Term]
id: sgd:S000000653
name: YCR057C
def: "Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0\, A1\, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PWP2" EXACT []
synonym: "UTP1" EXACT []
synonym: "YCR055C" EXACT []
synonym: "YCR058C" EXACT []

[Term]
id: sgd:S000000655
name: YCR059C
def: "Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIH1" EXACT []

[Term]
id: sgd:S000000656
name: YCR060W
def: "Component of conserved R2TP complex \(Rvb1-Rvb2-Tah1-Pih1\); R2TP complex interacts with Hsp90 \(Hsp82p and Hsc82p\) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAH1" EXACT []

[Term]
id: sgd:S000000657
name: YCR061W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCR062W" EXACT []

[Term]
id: sgd:S000000659
name: YCR063W
def: "Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start\, but is not required for G2/M transition or exit from mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD31" EXACT []
synonym: "CWC14" EXACT []

[Term]
id: sgd:S000000660
name: YCR064C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene BUD31" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000661
name: YCR065W
def: "Forkhead transcription factor; drives S-phase specific expression of genes involved in chromosome segregation\, spindle dynamics\, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role; regulates replicative lifespan; ortholog of C. elegans lifespan regulator PHA-4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCM1" EXACT []

[Term]
id: sgd:S000000662
name: YCR066W
def: "E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase \(STUbl\) that contains a SUMO-interacting motif \(SIM\) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase RAD18" EXACT []
synonym: "RAD18" EXACT []

[Term]
id: sgd:S000000663
name: YCR067C
def: "Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog\, SEC12\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SED4" EXACT []

[Term]
id: sgd:S000000664
name: YCR068W
def: "Lipase required for intravacuolar lysis of autophagic and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body \(MVB\) pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG15" EXACT []
synonym: "AUT5" EXACT []
synonym: "CVT17" EXACT []
synonym: "triglyceride lipase ATG15" EXACT []

[Term]
id: sgd:S000000665
name: YCR069W
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog\, CPR8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR4" EXACT []
synonym: "CYP4" EXACT []
synonym: "SCC3" EXACT []
synonym: "YCR070W" EXACT []
synonym: "peptidylprolyl isomerase family protein CPR4" EXACT []

[Term]
id: sgd:S000000667
name: YCR071C
def: "Mitochondrial ribosomal protein of the large subunit; conserved in metazoa\, with similarity to human mitochondrial ribosomal protein MRPL49" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMG2" EXACT []
synonym: "mitochondrial 54S ribosomal protein IMG2" EXACT []

[Term]
id: sgd:S000000668
name: YCR072C
def: "WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits\, localizes to the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSA4" EXACT []

[Term]
id: sgd:S000000669
name: YCR073C
def: "MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog\, SSK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSK22" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase SSK22" EXACT []

[Term]
id: sgd:S000000671
name: YCR075C
def: "Protein with similarity to human cystinosin; cystinosin is a H\(+\)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERS1" EXACT []

[Term]
id: sgd:S000000672
name: YCR076C
def: "Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1\, a proteasome inhibitor; not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUB1" EXACT []

[Term]
id: sgd:S000000673
name: YCR077C
def: "Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission\, maintenance of rDNA locus stability\, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation\, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRT1" EXACT []
synonym: "PAT1" EXACT []

[Term]
id: sgd:S000000677
name: YCR081W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIG1" EXACT []
synonym: "MED12" EXACT []
synonym: "NUT6" EXACT []
synonym: "SRB8" EXACT []
synonym: "SSN5" EXACT []
synonym: "YCR080W" EXACT []

[Term]
id: sgd:S000000678
name: YCR082W
def: "Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AHC2" EXACT []

[Term]
id: sgd:S000000679
name: YCR083W
def: "Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell\, forms the mitochondrial thioredoxin system with Trr2p\, redox state is maintained by both Trr2p and Glr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRX3" EXACT []

[Term]
id: sgd:S000000680
name: YCR084C
def: "General repressor of transcription; forms complex with Cyc8p\, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4\, appears to enhance expression of some genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAR1" EXACT []
synonym: "AER2" EXACT []
synonym: "AMM1" EXACT []
synonym: "CRT4" EXACT []
synonym: "CYC9" EXACT []
synonym: "FLK1" EXACT []
synonym: "ROX4" EXACT []
synonym: "SFL2" EXACT []
synonym: "TUP1" EXACT []
synonym: "UMR7" EXACT []
synonym: "chromatin-silencing transcriptional regulator TUP1" EXACT []

[Term]
id: sgd:S000000681
name: YCR085W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000682
name: YCR086W
def: "Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSM1" EXACT []

[Term]
id: sgd:S000000683
name: YCR087W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000684
name: YCR088W
def: "Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filament elongation; phosphorylation within its Proline-Rich Regio\, mediated by Cdc28p and Pho85p\, protects Abp1p from proteolysis mediated by its own PEST sequences; mammalian homologue of HIP-55 \(hematopoietic progenitor kinase 1 \[HPK1\]-interacting protein of 55 kDa\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABP1" EXACT []

[Term]
id: sgd:S000000685
name: YCR089W
def: "Cell wall adhesin\, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog\, AGA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIG2" EXACT []

[Term]
id: sgd:S000000686
name: YCR090C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000687
name: YCR091W
def: "Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases \(flippases\); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog\, FPK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FPK2" EXACT []
synonym: "KIN82" EXACT []
synonym: "putative serine/threonine protein kinase KIN82" EXACT []

[Term]
id: sgd:S000000688
name: YCR092C
def: "Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends\, contains a PCNA \(Pol30p\) binding motif required for genome stability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH3" EXACT []
synonym: "mismatch repair protein MSH3" EXACT []

[Term]
id: sgd:S000000689
name: YCR093W
def: "Component of the CCR4-NOT1 core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4-NOT core subunit CDC39" EXACT []
synonym: "CDC39" EXACT []
synonym: "NOT1" EXACT []
synonym: "ROS1" EXACT []
synonym: "SMD6" EXACT []

[Term]
id: sgd:S000000690
name: YCR094W
def: "Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog\, YNR048W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC50" EXACT []
synonym: "aminophospholipid translocase regulatory protein CDC50" EXACT []

[Term]
id: sgd:S000000691
name: YCR095C
def: "Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA4" EXACT []

[Term]
id: sgd:S000000692
name: YCR096C
def: "Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A2" EXACT []
synonym: "HMRA2" EXACT []

[Term]
id: sgd:S000000694
name: YCR097W
def: "Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMRA1" EXACT []
synonym: "YCR097WB" EXACT []

[Term]
id: sgd:S000000695
name: YCR098C
def: "Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIT1" EXACT []

[Term]
id: sgd:S000000696
name: YCR099C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000697
name: YCR100C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000698
name: YCR101C
def: "Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000699
name: YCR102C
def: "Putative protein of unknown function; involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000701
name: YCR104W
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU3" EXACT []
synonym: "seripauperin PAU3" EXACT []

[Term]
id: sgd:S000000702
name: YCR105W
def: "NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH7" EXACT []
synonym: "ADHVII" EXACT []

[Term]
id: sgd:S000000703
name: YCR106W
def: "Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDS1" EXACT []

[Term]
id: sgd:S000000704
name: YCR107W
def: "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog\, AAD15\, that arose from a segmental duplication; members of the AAD gene family comprise three pairs \(AAD3 + AAD15\, AAD6/AAD16 + AAD4\, AAD10 + AAD14\) whose two genes are more related to one another than to other members of the family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAD3" EXACT []

[Term]
id: sgd:S000000718
name: YCR073W-A
def: "Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog\, SOL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOL2" EXACT []
synonym: "YCRX13W" EXACT []

[Term]
id: sgd:S000000727
name: YEL001C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC22" EXACT []

[Term]
id: sgd:S000000728
name: YEL002C
def: "Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WBP1" EXACT []

[Term]
id: sgd:S000000729
name: YEL003W
def: "Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM4" EXACT []
synonym: "PFD2" EXACT []

[Term]
id: sgd:S000000730
name: YEL004W
def: "Uridine diphosphate-N-acetylglucosamine \(UDP-GlcNAc\) transporter; required for cell wall chitin synthesis; localized to the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEA4" EXACT []

[Term]
id: sgd:S000000731
name: YEL005C
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function\, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAB2" EXACT []
synonym: "VAB31" EXACT []

[Term]
id: sgd:S000000732
name: YEL006W
def: "Putative mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily \(see also YIA6\); has putative human ortholog; YEA6 has a paralog\, YIA6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDT2" EXACT []
synonym: "YEA6" EXACT []

[Term]
id: sgd:S000000733
name: YEL007W
def: "Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ \(gluconate transport inducer 1\) and C. albicans Wor1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIT1" EXACT []
synonym: "TOS9" EXACT []

[Term]
id: sgd:S000000734
name: YEL008W
def: "Hypothetical protein predicted to be involved in metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000735
name: YEL009C
def: "bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAS101" EXACT []
synonym: "AAS3" EXACT []
synonym: "ARG9" EXACT []
synonym: "GCN4" EXACT []
synonym: "amino acid starvation-responsive transcription factor GCN4" EXACT []

[Term]
id: sgd:S000000736
name: YEL010W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000737
name: YEL011W
def: "Glycogen branching enzyme\, involved in glycogen accumulation; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1" EXACT []
synonym: "4-alpha-glucan branching enzyme" EXACT []
synonym: "GHA1" EXACT []
synonym: "GLC3" EXACT []

[Term]
id: sgd:S000000738
name: YEL012W
def: "Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1\,6-bisphosphatase \(FBPase\); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-conjugating protein UBC8" EXACT []
synonym: "GID3" EXACT []
synonym: "UBC8" EXACT []

[Term]
id: sgd:S000000739
name: YEL013W
def: "Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p\, required for the cytoplasm-to-vacuole targeting \(Cvt\) pathway; interacts with Nvj1p to form nucleus-vacuole junctions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAC8" EXACT []
synonym: "YEB3" EXACT []
synonym: "protein anchor VAC8" EXACT []

[Term]
id: sgd:S000000740
name: YEL014C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000741
name: YEL015W
def: "Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp \(or Rps28Ap\) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different\, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCP3" EXACT []
synonym: "EDC3" EXACT []
synonym: "LSM16" EXACT []

[Term]
id: sgd:S000000742
name: YEL016C
def: "Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP2 has a paralog\, NPP1\, that arose from the whole genome duplication\, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPP2" EXACT []

[Term]
id: sgd:S000000743
name: YEL017W
def: "Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTT3" EXACT []

[Term]
id: sgd:S000000744
name: YEL018W
def: "Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF5" EXACT []

[Term]
id: sgd:S000000745
name: YEL019C
def: "SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMS21" EXACT []
synonym: "NSE2" EXACT []
synonym: "PSO10" EXACT []
synonym: "SUMO ligase MMS21" EXACT []

[Term]
id: sgd:S000000746
name: YEL020C
def: "Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative indolepyruvate decarboxylase family protein" EXACT []

[Term]
id: sgd:S000000747
name: YEL021W
def: "Orotidine-5'-phosphate \(OMP\) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines\, converting OMP into uridine monophosphate \(UMP\); converts 5-FOA into 5-fluorouracil\, a toxic compound" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URA3" EXACT []
synonym: "orotidine-5'-phosphate decarboxylase" EXACT []

[Term]
id: sgd:S000000748
name: YEL022W
def: "Guanine nucleotide exchange factor for ADP ribosylation factors \(ARFs\); involved in vesicular transport between the Golgi and ER\, Golgi organization\, and actin cytoskeleton organization; GEA2 has a paralog\, GEA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor GEA2" EXACT []
synonym: "GEA2" EXACT []

[Term]
id: sgd:S000000749
name: YEL023C
def: "Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000750
name: YEL024W
def: "Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import\, Rip1p is first imported into the mitochondrial matrix where it is processed\, acquires its Fe-S cluster\, and is folded\, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p\, and finally is delivered by Bcs1p to Complex III for assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIP1" EXACT []
synonym: "ubiquinol--cytochrome-c reductase catalytic subunit RIP1" EXACT []

[Term]
id: sgd:S000000751
name: YEL025C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRI1" EXACT []

[Term]
id: sgd:S000000752
name: YEL026W
def: "RNA binding protein; part of U3 snoRNP involved in rRNA processing\, part of U4/U6-U5 tri-snRNP involved in mRNA splicing\, similar to human 15.5K protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA binding protein SNU13" EXACT []
synonym: "SNU13" EXACT []

[Term]
id: sgd:S000000753
name: YEL027W
def: "Proteolipid subunit c of the V0 domain of vacuolar H\(+\)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS7" EXACT []
synonym: "CUP5" EXACT []
synonym: "GEF2" EXACT []
synonym: "H(+)-transporting V0 sector ATPase subunit c" EXACT []
synonym: "VMA3" EXACT []

[Term]
id: sgd:S000000754
name: YEL028W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000755
name: YEL029C
def: "Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis\, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase \(PDXK\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD16" EXACT []
synonym: "putative pyridoxal kinase BUD16" EXACT []

[Term]
id: sgd:S000000756
name: YEL030W
def: "Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids\, plays a role in protein translocation\, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog\, SSC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM10" EXACT []
synonym: "Hsp70 family ATPase ECM10" EXACT []
synonym: "SSC3" EXACT []

[Term]
id: sgd:S000000757
name: YEL031W
def: "P-type ATPase\, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin \(SMKT\) produced by Pichia farinosa KK1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COD1" EXACT []
synonym: "PER9" EXACT []
synonym: "PIO1" EXACT []
synonym: "SPF1" EXACT []
synonym: "ion-transporting P-type ATPase SPF1" EXACT []

[Term]
id: sgd:S000000758
name: YEL032W
def: "Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCM DNA helicase complex subunit MCM3" EXACT []
synonym: "MCM3" EXACT []

[Term]
id: sgd:S000000759
name: YEL033W
def: "Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments\, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC7" EXACT []

[Term]
id: sgd:S000000760
name: YEL034W
def: "Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches\, including Bni1p\, and this leads to a requirement for mating projection formation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog\, ANB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HYP2" EXACT []
synonym: "TIF51A" EXACT []
synonym: "eIF-5A" EXACT []
synonym: "eIF5A" EXACT []
synonym: "translation elongation factor eIF-5A" EXACT []

[Term]
id: sgd:S000000761
name: YEL035C
def: "Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard \(aerobic\) conditions but not under anaerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTR5" EXACT []

[Term]
id: sgd:S000000762
name: YEL036C
def: "Subunit of the alpha-1\,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANP1" EXACT []
synonym: "GEM3" EXACT []
synonym: "MNN8" EXACT []

[Term]
id: sgd:S000000763
name: YEL037C
def: "Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 \(NEF2\) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved\, with Rad4p\, in ubiquitylated protein turnover" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD23" EXACT []

[Term]
id: sgd:S000000764
name: YEL038W
def: "Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTR4" EXACT []
synonym: "putative acireductone synthase UTR4" EXACT []

[Term]
id: sgd:S000000765
name: YEL039C
def: "Cytochrome c isoform 2\, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog\, CYC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYC7" EXACT []
synonym: "cytochrome c isoform 2" EXACT []

[Term]
id: sgd:S000000766
name: YEL040W
def: "Chitin transglycosylase; functions in the transfer of chitin to beta\(1-6\) and beta\(1-3\) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol \(GPI\)-anchored protein localized to bud neck" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRH2" EXACT []
synonym: "UTR2" EXACT []

[Term]
id: sgd:S000000767
name: YEL041W
def: "ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog\, UTR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEF1" EXACT []

[Term]
id: sgd:S000000768
name: YEL042W
def: "Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDA1" EXACT []

[Term]
id: sgd:S000000769
name: YEL043W
def: "Predicted cytoskeleton protein involved in intracellular signaling; based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes\, based on co-purification studies; contains fibronectin type III domain fold" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000770
name: YEL044W
def: "Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES6" EXACT []

[Term]
id: sgd:S000000771
name: YEL045C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion gives MMS sensitivity\, growth defect under alkaline conditions\, less than optimal growth upon citric acid stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000772
name: YEL046C
def: "Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLY1" EXACT []
synonym: "threonine aldolase GLY1" EXACT []

[Term]
id: sgd:S000000773
name: YEL047C
def: "Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes\, based on co-purification experiments; authentic\, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog\, OSM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRD1" EXACT []
synonym: "FRDS1" EXACT []

[Term]
id: sgd:S000000774
name: YEL048C
def: "Component of transport protein particle \(TRAPP\) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT\, a skeletal disorder" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCA17" EXACT []

[Term]
id: sgd:S000000775
name: YEL049W
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU2" EXACT []
synonym: "seripauperin PAU2" EXACT []

[Term]
id: sgd:S000000776
name: YEL050C
def: "Mitochondrial ribosomal protein of the large subunit \(L2\); has similarity to E. coli L2 ribosomal protein; mutant allele \(fat21\) causes inability to utilize oleate\, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RML2" EXACT []
synonym: "mitochondrial 54S ribosomal protein RML2" EXACT []

[Term]
id: sgd:S000000777
name: YEL051W
def: "Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase \(V-ATPase\) has eight subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V1 sector ATPase subunit D" EXACT []
synonym: "VMA8" EXACT []

[Term]
id: sgd:S000000778
name: YEL052W
def: "Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFG1" EXACT []

[Term]
id: sgd:S000000779
name: YEL053C
def: "Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; expression is glucose-repressible" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK10" EXACT []
synonym: "NAA35" EXACT []

[Term]
id: sgd:S000000780
name: YEL054C
def: "Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog\, RPL12B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L11" EXACT []
synonym: "L12A" EXACT []
synonym: "L15A" EXACT []
synonym: "RPL12A" EXACT []
synonym: "YL23" EXACT []
synonym: "ribosomal 60S subunit protein L12A" EXACT []

[Term]
id: sgd:S000000781
name: YEL055C
def: "DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases\, not required for chromosomal DNA replication; required for the synthesis of rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POL5" EXACT []

[Term]
id: sgd:S000000782
name: YEL056W
def: "Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4\, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAT2" EXACT []

[Term]
id: sgd:S000000783
name: YEL057C
def: "Protein of unknown function involved in telomere maintenance; target of UME6 regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000784
name: YEL058W
def: "Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P\, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGM1" EXACT []
synonym: "PCM1" EXACT []
synonym: "phosphoacetylglucosamine mutase PCM1" EXACT []

[Term]
id: sgd:S000000785
name: YEL059W
def: "Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV6" EXACT []
synonym: "HHY1" EXACT []

[Term]
id: sgd:S000000786
name: YEL060C
def: "Vacuolar proteinase B \(yscB\) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog\, YSP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CVT1" EXACT []
synonym: "PRB1" EXACT []
synonym: "proteinase B" EXACT []

[Term]
id: sgd:S000000787
name: YEL061C
def: "Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIN8" EXACT []
synonym: "KSL2" EXACT []
synonym: "SDS15" EXACT []
synonym: "kinesin motor protein CIN8" EXACT []

[Term]
id: sgd:S000000788
name: YEL062W
def: "Subunit of SEA \(Seh1-associated\)\, Npr2/3\, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex is required for non-nitrogen-starvation \(NNS\)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human tumor suppressor NPRL2; target of Grr1p; required for growth on urea and proline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPR2" EXACT []
synonym: "nitrogen permease regulating protein NPR2" EXACT []

[Term]
id: sgd:S000000789
name: YEL063C
def: "Plasma membrane arginine permease; requires phosphatidyl ethanolamine \(PE\) for localization\, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog\, ALP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAN1" EXACT []
synonym: "arginine permease CAN1" EXACT []

[Term]
id: sgd:S000000790
name: YEL064C
def: "Putative transporter; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT2" EXACT []

[Term]
id: sgd:S000000791
name: YEL065W
def: "Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARN3" EXACT []
synonym: "SIT1" EXACT []

[Term]
id: sgd:S000000792
name: YEL066W
def: "D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines\, also autoacetylates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPA3" EXACT []

[Term]
id: sgd:S000000793
name: YEL067C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000794
name: YEL068C
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000795
name: YEL069C
def: "Hexose transporter; induced in the presence of non-fermentable carbon sources\, induced by low levels of glucose\, repressed by high levels of glucose; HXT13 has a paralog\, HXT17\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT13" EXACT []
synonym: "hexose transporter HXT13" EXACT []

[Term]
id: sgd:S000000796
name: YEL070W
def: "Putative mannitol dehydrogenase; deletion suppressor of mpt5 mutation; DSF1 has a paralog\, YNR073C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSF1" EXACT []
synonym: "mannitol dehydrogenase DSF1" EXACT []

[Term]
id: sgd:S000000797
name: YEL071W
def: "D-lactate dehydrogenase; part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source\, located in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DLD3" EXACT []

[Term]
id: sgd:S000000798
name: YEL072W
def: "Protein required for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMD6" EXACT []

[Term]
id: sgd:S000000799
name: YEL073C
def: "Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000800
name: YEL074W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000801
name: YEL075C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000802
name: YEL076C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000803
name: YER001W
def: "Alpha-1\,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex\, required for addition of alpha1\,3-mannose linkages to N-linked and O-linked oligosaccharides\, one of five S. cerevisiae proteins of the MNN1 family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNN1" EXACT []

[Term]
id: sgd:S000000804
name: YER002W
def: "Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP16" EXACT []

[Term]
id: sgd:S000000805
name: YER003C
def: "Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMI" EXACT []
synonym: "PMI40" EXACT []
synonym: "mannose-6-phosphate isomerase PMI40" EXACT []

[Term]
id: sgd:S000000806
name: YER004W
def: "Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP52" EXACT []

[Term]
id: sgd:S000000807
name: YER005W
def: "Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APY1" EXACT []
synonym: "YEJ5" EXACT []
synonym: "YND1" EXACT []

[Term]
id: sgd:S000000808
name: YER006W
def: "GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUG1" EXACT []
synonym: "RNA-binding GTPase NUG1" EXACT []

[Term]
id: sgd:S000000809
name: YER007W
def: "Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin\, required for normal microtubule function\, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAC2" EXACT []

[Term]
id: sgd:S000000810
name: YER008C
def: "Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns\[4\,5\]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent\, actin-independent manner\, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSL1" EXACT []
synonym: "SEC3" EXACT []

[Term]
id: sgd:S000000811
name: YER009W
def: "Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTF2" EXACT []

[Term]
id: sgd:S000000812
name: YER010C
def: "Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II \(divalent metal ion dependent\) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000813
name: YER011W
def: "Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP1" EXACT []
synonym: "TIR1" EXACT []

[Term]
id: sgd:S000000814
name: YER012W
def: "Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE1" EXACT []
synonym: "proteasome core particle subunit beta 4" EXACT []

[Term]
id: sgd:S000000815
name: YER013W
def: "DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAH-box ATP-dependent RNA helicase PRP22" EXACT []
synonym: "PRP22" EXACT []

[Term]
id: sgd:S000000816
name: YER014W
def: "Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway\, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM14" EXACT []
synonym: "oxygen-dependent protoporphyrinogen oxidase" EXACT []

[Term]
id: sgd:S000000817
name: YER015W
def: "Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains\, C9\:0-C13\:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAA2" EXACT []
synonym: "FAM1" EXACT []
synonym: "medium-chain fatty acid-CoA ligase FAA2" EXACT []

[Term]
id: sgd:S000000818
name: YER016W
def: "Microtubule plus end-tracking protein; together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIM1" EXACT []
synonym: "EB1" EXACT []
synonym: "YEB1" EXACT []
synonym: "microtubule-binding protein BIM1" EXACT []

[Term]
id: sgd:S000000819
name: YER017C
def: "Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase AFG3" EXACT []
synonym: "AFG3" EXACT []
synonym: "YTA10" EXACT []

[Term]
id: sgd:S000000820
name: YER018C
def: "Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation\, spindle checkpoint activity\, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p\, Nuf2p\, Spc24p\, and Spc25p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC25" EXACT []

[Term]
id: sgd:S000000821
name: YER019W
def: "Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; activated by phosphatidylserine\, cardiolipin\, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISC1" EXACT []
synonym: "inositol phosphosphingolipid phospholipase" EXACT []

[Term]
id: sgd:S000000822
name: YER020W
def: "Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p\, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPA2" EXACT []
synonym: "SSP101" EXACT []
synonym: "guanine nucleotide-binding protein subunit alpha" EXACT []

[Term]
id: sgd:S000000823
name: YER021W
def: "Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest\, suggesting a role for the proteasome in cell cycle control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN3" EXACT []
synonym: "SUN2" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN3" EXACT []

[Term]
id: sgd:S000000824
name: YER022W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED17" EXACT []
synonym: "SRB4" EXACT []

[Term]
id: sgd:S000000825
name: YER023W
def: "Delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORE2" EXACT []
synonym: "PRO3" EXACT []
synonym: "pyrroline-5-carboxylate reductase" EXACT []

[Term]
id: sgd:S000000826
name: YER024W
def: "Carnitine acetyltransferase; has similarity to Yat1p\, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAT2" EXACT []
synonym: "carnitine O-acetyltransferase YAT2" EXACT []

[Term]
id: sgd:S000000827
name: YER025W
def: "Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability \(XLID\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD11" EXACT []
synonym: "SUI4" EXACT []
synonym: "translation initiation factor eIF2 subunit gamma" EXACT []

[Term]
id: sgd:S000000828
name: YER026C
def: "Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine\, transcriptionally repressed by myo-inositol and choline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDP-diacylglycerol-serine O-phosphatidyltransferase" EXACT []
synonym: "CHO1" EXACT []
synonym: "PSS1" EXACT []

[Term]
id: sgd:S000000829
name: YER027C
def: "One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain; GAL83 has a paralog\, SIP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL83" EXACT []
synonym: "SPM1" EXACT []

[Term]
id: sgd:S000000830
name: YER028C
def: "Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p\, allowing induction of damage response genesenvironment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIG3" EXACT []

[Term]
id: sgd:S000000831
name: YER029C
def: "Core Sm protein Sm B; part of heteroheptameric complex \(with Smd1p\, Smd2p\, Smd3p\, Sme1p\, Smx3p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm B and Sm B'" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMB1" EXACT []
synonym: "Sm B" EXACT []
synonym: "SmB" EXACT []

[Term]
id: sgd:S000000832
name: YER030W
def: "Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHZ1" EXACT []

[Term]
id: sgd:S000000833
name: YER031C
def: "Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog\, YPT32\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT31" EXACT []
synonym: "YPT31" EXACT []
synonym: "YPT8" EXACT []

[Term]
id: sgd:S000000834
name: YER032W
def: "Protein involved in 3' mRNA processing; interacts with Ref2p; APCC\(Cdh1\) substrate; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIR1" EXACT []
synonym: "PIP1" EXACT []

[Term]
id: sgd:S000000835
name: YER033C
def: "Protein of unknown function; authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZRG8" EXACT []

[Term]
id: sgd:S000000836
name: YER034W
def: "Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000837
name: YER035W
def: "RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog\, EDC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EDC2" EXACT []

[Term]
id: sgd:S000000838
name: YER036C
def: "ATPase of the ATP-binding cassette \(ABC\) family; involved in 40S and 60S ribosome biogenesis\, has similarity to Gcn20p; shuttles from nucleus to cytoplasm\, physically interacts with Tif6p\, Lsg1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARB1" EXACT []
synonym: "ATP-binding cassette family ATPase ARB1" EXACT []

[Term]
id: sgd:S000000839
name: YER037W
def: "Lysophosphatidic acid \(LPA\) phosphatase\, nucleotidase; principle and physiological nucleotidase working on GMP\, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; PHM8 has a paralog\, SDT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM8" EXACT []

[Term]
id: sgd:S000000840
name: YER038C
def: "Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE29" EXACT []
synonym: "NSE6" EXACT []

[Term]
id: sgd:S000000841
name: YER039C
def: "Protein of unknown function; HVG1 has a paralog\, VRG4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HVG1" EXACT []
synonym: "YEM9" EXACT []

[Term]
id: sgd:S000000842
name: YER040W
def: "Transcriptional activator of genes regulated by nitrogen catabolite repression; localization and activity regulated by quality of nitrogen source and Ure2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLN3" EXACT []
synonym: "nitrogen-responsive transcriptional regulator GLN3" EXACT []

[Term]
id: sgd:S000000843
name: YER041W
def: "Holliday junction resolvase; promotes template switching during break-induced replication \(BIR\)\, causing non-reciprocal translocations \(NRTs\); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEN1" EXACT []

[Term]
id: sgd:S000000844
name: YER042W
def: "Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MXR1" EXACT []
synonym: "msrA" EXACT []

[Term]
id: sgd:S000000845
name: YER043C
def: "S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine \(AdoMet\) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine\(PC\)synthesis and triacylglycerol \(TG\) levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAH1" EXACT []
synonym: "adenosylhomocysteinase" EXACT []

[Term]
id: sgd:S000000846
name: YER044C
def: "Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER\, also interacts with Erg6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD18" EXACT []
synonym: "ERG28" EXACT []

[Term]
id: sgd:S000000847
name: YER045C
def: "ATF/CREB family basic leucine zipper \(bZIP\) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog\, CST6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACA1" EXACT []

[Term]
id: sgd:S000000848
name: YER046W
def: "Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO73" EXACT []

[Term]
id: sgd:S000000849
name: YER047C
def: "Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP1" EXACT []
synonym: "putative AAA family ATPase SAP1" EXACT []

[Term]
id: sgd:S000000850
name: YER048C
def: "Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif\, binds to non-native substrates for presentation to Ssa3p\, may function during protein translocation\, assembly and disassembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAJ1" EXACT []

[Term]
id: sgd:S000000851
name: YER049W
def: "Fe\(II\)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly\(rA\)-binding protein involved in mRNA poly\(A\) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p \(eRF1\)\, Sup35p \(eRF3\) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe\(II\) and 2-oxoglutarate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPA1" EXACT []

[Term]
id: sgd:S000000852
name: YER050C
def: "Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM18" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM18" EXACT []

[Term]
id: sgd:S000000853
name: YER051W
def: "JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human\, mouse\, drosophila\, X. laevis\, C. elegans\, and S. pombe" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JHD1" EXACT []
synonym: "JHDM1" EXACT []
synonym: "KDM2" EXACT []

[Term]
id: sgd:S000000854
name: YER052C
def: "Aspartate kinase \(L-aspartate 4-P-transferase\); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOR1" EXACT []
synonym: "HOM3" EXACT []
synonym: "SIL4" EXACT []
synonym: "THR3" EXACT []
synonym: "aspartate kinase" EXACT []

[Term]
id: sgd:S000000855
name: YER053C
def: "Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIC2" EXACT []

[Term]
id: sgd:S000000856
name: YER054C
def: "Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif \(GVNK motif\) that is also found in Gac1p\, Pig1p\, and Pig2p; GIP2 has a paralog\, PIG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIP2" EXACT []

[Term]
id: sgd:S000000857
name: YER055C
def: "ATP phosphoribosyltransferase; a hexameric enzyme\, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu\, Co\, and Ni salts; transcription is regulated by general amino acid control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP phosphoribosyltransferase" EXACT []
synonym: "HIS1" EXACT []

[Term]
id: sgd:S000000858
name: YER056C
def: "Purine-cytosine permease; mediates purine \(adenine\, guanine\, and hypoxanthine\) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRA7" EXACT []
synonym: "FCY2" EXACT []

[Term]
id: sgd:S000000859
name: YER057C
def: "Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog\, MMF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIG1" EXACT []
synonym: "HMF1" EXACT []

[Term]
id: sgd:S000000860
name: YER058W
def: "Protein required for assembly of cytochrome c oxidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET117" EXACT []

[Term]
id: sgd:S000000861
name: YER059W
def: "Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog\, PCL7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL6" EXACT []

[Term]
id: sgd:S000000862
name: YER060W
def: "Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCY21" EXACT []

[Term]
id: sgd:S000000863
name: YER061C
def: "Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEM1" EXACT []
synonym: "fatty acid synthase CEM1" EXACT []

[Term]
id: sgd:S000000864
name: YER062C
def: "DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress\, and during diauxic shift; GPP2 has a paralog\, GPP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPP2" EXACT []
synonym: "HOR2" EXACT []
synonym: "glycerol-1-phosphatase HOR2" EXACT []

[Term]
id: sgd:S000000865
name: YER063W
def: "Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner\, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THO1" EXACT []

[Term]
id: sgd:S000000866
name: YER064C
def: "Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog\, VHR1\, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHR2" EXACT []

[Term]
id: sgd:S000000867
name: YER065C
def: "Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate\, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICL1" EXACT []
synonym: "isocitrate lyase 1" EXACT []

[Term]
id: sgd:S000000868
name: YER066W
def: "Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT13" EXACT []

[Term]
id: sgd:S000000869
name: YER067W
def: "Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog\, RGI2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGI1" EXACT []

[Term]
id: sgd:S000000870
name: YER068W
def: "Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p\, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation\, mRNA degradation\, and post-transcriptional modifications; regulates levels of DNA Polymerase-\{alpha\} to promote efficient and accurate DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4-NOT core ubiquitin-protein ligase subunit MOT2" EXACT []
synonym: "MOT2" EXACT []
synonym: "NOT4" EXACT []
synonym: "SIG1" EXACT []

[Term]
id: sgd:S000000871
name: YER069W
def: "Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase \(NAGK\) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase \(NAGSA\)\, the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes\, slows catalysis and is involved in feed-back inhibition by arginine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG5,6" EXACT []
synonym: "bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase" EXACT []

[Term]
id: sgd:S000000872
name: YER070W
def: "Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis\, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog\, RNR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT7" EXACT []
synonym: "RIR1" EXACT []
synonym: "RNR1" EXACT []
synonym: "SDS12" EXACT []
synonym: "ribonucleotide-diphosphate reductase subunit RNR1" EXACT []

[Term]
id: sgd:S000000873
name: YER071C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA2" EXACT []

[Term]
id: sgd:S000000874
name: YER072W
def: "Subunit of the vacuolar transporter chaperone \(VTC\) complex; VTC complex is involved in membrane trafficking\, vacuolar polyphosphate accumulation\, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRF1" EXACT []
synonym: "PHM4" EXACT []
synonym: "VTC1" EXACT []

[Term]
id: sgd:S000000875
name: YER073W
def: "Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALD5" EXACT []
synonym: "aldehyde dehydrogenase (NAD(P)(+)) ALD5" EXACT []

[Term]
id: sgd:S000000876
name: YER074W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S24\, no bacterial homolog; RPS24A has a paralog\, RPS24B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS24A" EXACT []
synonym: "RPS24EA" EXACT []
synonym: "S24A" EXACT []
synonym: "S24e" EXACT []
synonym: "ribosomal 40S subunit protein S24A" EXACT []

[Term]
id: sgd:S000000877
name: YER075C
def: "Phosphotyrosine-specific protein phosphatase; involved in the inactivation of mitogen-activated protein kinase \(MAPK\) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTP3" EXACT []
synonym: "tyrosine protein phosphatase PTP3" EXACT []

[Term]
id: sgd:S000000878
name: YER076C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000879
name: YER077C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000880
name: YER078C
def: "Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase \(MPP\)\, thereby increasing their stability; member of the aminopeptidase P family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICP55" EXACT []

[Term]
id: sgd:S000000881
name: YER079W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000882
name: YER080W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM9" EXACT []
synonym: "FMP29" EXACT []

[Term]
id: sgd:S000000883
name: YER081W
def: "3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog\, SER33\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SER3" EXACT []
synonym: "phosphoglycerate dehydrogenase SER3" EXACT []

[Term]
id: sgd:S000000884
name: YER082C
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE31" EXACT []
synonym: "UTP7" EXACT []

[Term]
id: sgd:S000000885
name: YER083C
def: "Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GET2" EXACT []
synonym: "HUR2" EXACT []
synonym: "RMD7" EXACT []

[Term]
id: sgd:S000000886
name: YER084W
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000887
name: YER085C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000888
name: YER086W
def: "Threonine deaminase\, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILV1" EXACT []
synonym: "ISO1" EXACT []
synonym: "threonine ammonia-lyase ILV1" EXACT []

[Term]
id: sgd:S000000889
name: YER087W
def: "Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM10" EXACT []
synonym: "putative proline--tRNA ligase AIM10" EXACT []

[Term]
id: sgd:S000000890
name: YER088C
def: "Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOT6" EXACT []
synonym: "PBF2" EXACT []

[Term]
id: sgd:S000000891
name: YER089C
def: "Type 2C protein phosphatase \(PP2C\); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog\, PTC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTC2" EXACT []
synonym: "type 2C protein phosphatase PTC2" EXACT []

[Term]
id: sgd:S000000892
name: YER090W
def: "Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis\, forms multifunctional hetero-oligomeric anthranilate synthase\:indole-3-glycerol phosphate synthase enzyme complex with Trp3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRP2" EXACT []
synonym: "anthranilate synthase TRP2" EXACT []

[Term]
id: sgd:S000000893
name: YER091C
def: "Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate\, similar to bacterial metE homologs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase" EXACT []
synonym: "MET6" EXACT []

[Term]
id: sgd:S000000894
name: YER092W
def: "Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES5" EXACT []

[Term]
id: sgd:S000000895
name: YER093C
def: "Subunit of TORC2 \(Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p\); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVO3" EXACT []
synonym: "TSC11" EXACT []

[Term]
id: sgd:S000000896
name: YER094C
def: "Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUP3" EXACT []
synonym: "SCS32" EXACT []
synonym: "proteasome core particle subunit beta 3" EXACT []

[Term]
id: sgd:S000000897
name: YER095W
def: "Strand exchange protein; forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUT5" EXACT []
synonym: "RAD51" EXACT []
synonym: "recombinase RAD51" EXACT []

[Term]
id: sgd:S000000898
name: YER096W
def: "Sporulation-specific activator of Chs3p \(chitin synthase III\); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog\, SKT5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHC1" EXACT []

[Term]
id: sgd:S000000899
name: YER097W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000900
name: YER098W
def: "Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog\, UBP13\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP9" EXACT []

[Term]
id: sgd:S000000901
name: YER099C
def: "5-phospho-ribosyl-1\(alpha\)-pyrophosphate synthetase\, synthesizes PRPP; which is required for nucleotide\, histidine\, and tryptophan biosynthesis; one of five related enzymes\, which are active as heteromultimeric complexes; PRS2 has a paralog\, PRS4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRS2" EXACT []
synonym: "ribose phosphate diphosphokinase subunit PRS2" EXACT []

[Term]
id: sgd:S000000902
name: YER100W
def: "Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA2" EXACT []
synonym: "E2 ubiquitin-conjugating protein UBC6" EXACT []
synonym: "UBC6" EXACT []

[Term]
id: sgd:S000000903
name: YER101C
def: "Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases \(MDRs\) superfamily; AST2 has a paralog\, AST1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AST2" EXACT []

[Term]
id: sgd:S000000904
name: YER102W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S8\, no bacterial homolog; RPS8B has a paralog\, RPS8A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS8B" EXACT []
synonym: "S14B" EXACT []
synonym: "S8B" EXACT []
synonym: "S8e" EXACT []
synonym: "YS9" EXACT []
synonym: "ribosomal 40S subunit protein S8B" EXACT []
synonym: "rp19" EXACT []

[Term]
id: sgd:S000000905
name: YER103W
def: "Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog\, SSA3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family chaperone SSA4" EXACT []
synonym: "SSA4" EXACT []
synonym: "YG107" EXACT []

[Term]
id: sgd:S000000906
name: YER104W
def: "Protein with a role in regulation of Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTT105" EXACT []

[Term]
id: sgd:S000000907
name: YER105C
def: "Subunit of the inner ring of the nuclear pore complex \(NPC\); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog\, NUP170\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP157" EXACT []

[Term]
id: sgd:S000000908
name: YER106W
def: "Monopolin; kinetochore associated protein involved in chromosome attachment to meiotic spindle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAM1" EXACT []

[Term]
id: sgd:S000000909
name: YER107C
def: "RNA export factor associated with the nuclear pore complex \(NPC\); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLE2" EXACT []
synonym: "RAE1" EXACT []
synonym: "RNA export factor GLE2" EXACT []

[Term]
id: sgd:S000000912
name: YER110C
def: "Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore\, nucleus\, and cytoplasm; exhibits genetic interactions with RAI1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP123" EXACT []
synonym: "YRB4" EXACT []

[Term]
id: sgd:S000000913
name: YER111C
def: "DNA binding component of the SBF complex \(Swi4p-Swi6p\); a transcriptional activator that in concert with MBF \(Mbp1-Swi6p\) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites\, K1016 and K1066\, regulates interaction with Swi6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART1" EXACT []
synonym: "SBF complex DNA-binding subunit SWI4" EXACT []
synonym: "SWI4" EXACT []

[Term]
id: sgd:S000000914
name: YER112W
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM4" EXACT []
synonym: "SDB23" EXACT []
synonym: "USS1" EXACT []

[Term]
id: sgd:S000000915
name: YER113C
def: "Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMN3" EXACT []

[Term]
id: sgd:S000000916
name: YER114C
def: "Protein implicated in polar growth\, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 \(src homology 3\) domain and a PH \(pleckstrin homology\) domain; BOI2 has a paralog\, BOI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEB1" EXACT []
synonym: "BOI2" EXACT []

[Term]
id: sgd:S000000917
name: YER115C
def: "Protein of unknown function; expressed during sporulation; not required for sporulation\, but gene exhibits genetic interactions with other genes required for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPR6" EXACT []

[Term]
id: sgd:S000000918
name: YER116C
def: "Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase \(STUbL\) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; null mutants are aneuploid\, have a metaphase delay\, and spindle defects including\: mispositioned spindles\, fish hook spindles\, and aberrant spindle kinetics; required for maintenance of genome integrity like human ortholog RNF4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLX8" EXACT []
synonym: "SUMO-targeted ubiquitin ligase complex subunit SLX8" EXACT []

[Term]
id: sgd:S000000919
name: YER117W
def: "Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog\, RPL23A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L14" EXACT []
synonym: "L17aB" EXACT []
synonym: "L23B" EXACT []
synonym: "RPL23B" EXACT []
synonym: "YL32" EXACT []
synonym: "ribosomal 60S subunit protein L23B" EXACT []

[Term]
id: sgd:S000000920
name: YER118C
def: "Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol \(HOG\) response pathway; phosphorylated by Hog1p; interacts with Pbs2p\, Msb2p\, Hkr1p\, and Ste11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHO1" EXACT []
synonym: "SSU81" EXACT []
synonym: "osmosensor SHO1" EXACT []

[Term]
id: sgd:S000000921
name: YER119C
def: "Vacuolar aspartate and glutamate exporter; member of a family of seven genes \(AVT1-7\) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog\, AVT5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT6" EXACT []

[Term]
id: sgd:S000000922
name: YER120W
def: "Integral ER membrane protein\, regulates phospholipid metabolism; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to the plasma membrane \(PM\) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog\, SCS22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCS2" EXACT []
synonym: "phosphatidylinositol-binding protein SCS2" EXACT []

[Term]
id: sgd:S000000923
name: YER121W
def: "Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000924
name: YER122C
def: "ADP-ribosylation factor GTPase activating protein \(ARF GAP\); involved in ER-Golgi transport; shares functional similarity with Gcs1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLO3" EXACT []

[Term]
id: sgd:S000000925
name: YER123W
def: "Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKI3" EXACT []
synonym: "YCK3" EXACT []
synonym: "casein kinase YCK3" EXACT []

[Term]
id: sgd:S000000926
name: YER124C
def: "Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSE1" EXACT []

[Term]
id: sgd:S000000927
name: YER125W
def: "E3 ubiquitin ligase of NEDD4 family; regulates many cellular processes including MVB sorting\, heat shock response\, transcription\, endocytosis\, ribosome stability; mutant tolerates aneuploidy; autoubiquitinates; ubiquitinates Sec23p and Sna3p; deubiquitinated by Ubp2p; activity regulated by SUMO ligase Siz1p\, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; human homolog implicated in Liddle syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDP1" EXACT []
synonym: "MUT2" EXACT []
synonym: "NEDD4 family E3 ubiquitin-protein ligase" EXACT []
synonym: "NPI1" EXACT []
synonym: "RSP5" EXACT []
synonym: "SMM1" EXACT []
synonym: "UBY1" EXACT []

[Term]
id: sgd:S000000928
name: YER126C
def: "Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSA2" EXACT []

[Term]
id: sgd:S000000929
name: YER127W
def: "Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCP5" EXACT []

[Term]
id: sgd:S000000930
name: YER128W
def: "Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VFA1" EXACT []

[Term]
id: sgd:S000000931
name: YER129W
def: "Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1\, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog\, TOS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAK1" EXACT []
synonym: "SAK1" EXACT []
synonym: "serine/threonine protein kinase SAK1" EXACT []

[Term]
id: sgd:S000000932
name: YER130C
def: "Transcription factor that binds IME1 Upstream Activation Signal \(UAS\)ru; COM2 transcription is regulated by Haa1p\, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog \(MNL1\) plays a role in adaptation to stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COM2" EXACT []

[Term]
id: sgd:S000000933
name: YER131W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S26\, no bacterial homolog; RPS26B has a paralog\, RPS26A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS26B" EXACT []
synonym: "S26B" EXACT []
synonym: "S26e" EXACT []
synonym: "ribosomal 40S subunit protein S26B" EXACT []

[Term]
id: sgd:S000000934
name: YER132C
def: "Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required\, with Mds3p\, for growth under alkaline conditions; PMD1 has a paralog\, MDS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMD1" EXACT []

[Term]
id: sgd:S000000935
name: YER133W
def: "Type 1 serine/threonine protein phosphatase catalytic subunit; cleavage and polyadenylation factor \(CPF\) component; involved in various processes including glycogen metabolism\, sporulation\, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CID1" EXACT []
synonym: "DIS2" EXACT []
synonym: "DIS2S1" EXACT []
synonym: "GLC7" EXACT []
synonym: "PP1" EXACT []
synonym: "type 1 serine/threonine-protein phosphatase catalytic subunit GLC7" EXACT []

[Term]
id: sgd:S000000936
name: YER134C
def: "Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDP-1" EXACT []
synonym: "Mg-dependent acid phosphatase" EXACT []

[Term]
id: sgd:S000000937
name: YER135C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YER135C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000938
name: YER136W
def: "GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDI1" EXACT []
synonym: "SEC19" EXACT []

[Term]
id: sgd:S000000939
name: YER137C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000941
name: YER139C
def: "CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog\, RTR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTR1" EXACT []

[Term]
id: sgd:S000000942
name: YER140W
def: "ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response \(UPR\); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMP65" EXACT []

[Term]
id: sgd:S000000943
name: YER141W
def: "Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX15" EXACT []

[Term]
id: sgd:S000000944
name: YER142C
def: "3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAG1" EXACT []
synonym: "MMS5" EXACT []

[Term]
id: sgd:S000000945
name: YER143W
def: "DNA damage-inducible v-SNARE binding protein; role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated \(UBA\)\, ubiquitin-like \(UBL\)\, and retroviral-like proteinase \(RVP\) domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDI1" EXACT []
synonym: "VSM1" EXACT []

[Term]
id: sgd:S000000946
name: YER144C
def: "Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog\, DOA4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP5" EXACT []

[Term]
id: sgd:S000000947
name: YER145C
def: "High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FTR1" EXACT []
synonym: "high-affinity iron permease FTR1" EXACT []

[Term]
id: sgd:S000000948
name: YER146W
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM5" EXACT []
synonym: "RNA-binding protein LSM5" EXACT []

[Term]
id: sgd:S000000949
name: YER147C
def: "Subunit of cohesin loading factor \(Scc2p-Scc4p\); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCC4" EXACT []

[Term]
id: sgd:S000000950
name: YER148W
def: "TATA-binding protein; general transcription factor that interacts with other factors to form the preinitiation complex at promoters\, essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTF1" EXACT []
synonym: "SPT15" EXACT []
synonym: "TATA-binding protein" EXACT []
synonym: "TBP" EXACT []
synonym: "TBP1" EXACT []

[Term]
id: sgd:S000000951
name: YER149C
def: "Coiled-coil 12S polarisome subunit; required for polarity establishment\, apical bud growth\, shmoo formation\, filamentous differentiation; involved in Bni1p localization at sites of polarized growth\, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx\, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFG9" EXACT []
synonym: "PEA2" EXACT []
synonym: "PPF2" EXACT []

[Term]
id: sgd:S000000952
name: YER150W
def: "GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog\, SED1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPI1" EXACT []

[Term]
id: sgd:S000000953
name: YER151C
def: "Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress; role in ribophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLM3" EXACT []
synonym: "UBP3" EXACT []
synonym: "mRNA-binding ubiquitin-specific protease UBP3" EXACT []

[Term]
id: sgd:S000000954
name: YER152C
def: "Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-aminoadipate transaminase" EXACT []

[Term]
id: sgd:S000000955
name: YER153C
def: "Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET122" EXACT []

[Term]
id: sgd:S000000956
name: YER154W
def: "Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel\, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OXA1" EXACT []
synonym: "PET1402" EXACT []

[Term]
id: sgd:S000000957
name: YER155C
def: "Rho GTPase activating protein \(RhoGAP\); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEM2" EXACT []
synonym: "IPL2" EXACT []
synonym: "SUP9" EXACT []
synonym: "TSL1" EXACT []

[Term]
id: sgd:S000000958
name: YER156C
def: "Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1\, a copper-responsive transcription factor; similarity to mammalian MYG1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000959
name: YER157W
def: "Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COG3" EXACT []
synonym: "GRD20" EXACT []
synonym: "SEC34" EXACT []

[Term]
id: sgd:S000000960
name: YER158C
def: "Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog\, AFR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000961
name: YER159C
def: "Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUR6" EXACT []
synonym: "NCB1" EXACT []

[Term]
id: sgd:S000000963
name: YER161C
def: "Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EXA1" EXACT []
synonym: "SIN1" EXACT []
synonym: "SPT2" EXACT []

[Term]
id: sgd:S000000964
name: YER162C
def: "Protein that recognizes and binds damaged DNA \(with Rad23p\) during NER; subunit of Nuclear Excision Repair Factor 2 \(NEF2\); also involved\, with Rad23p\, in turnover of ubiquitylated proteins; NER stands for nucleotide excision repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD4" EXACT []

[Term]
id: sgd:S000000965
name: YER163C
def: "Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCG1" EXACT []

[Term]
id: sgd:S000000966
name: YER164W
def: "Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain\, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHD1" EXACT []
synonym: "chromatin-remodeling ATPase CHD1" EXACT []

[Term]
id: sgd:S000000967
name: YER165W
def: "Poly\(A\) binding protein; part of the 3'-end RNA-processing complex\, mediates interactions between the 5' cap structure and the 3' mRNA poly\(A\) tail\, involved in control of poly\(A\) tail length\, interacts with translation factor eIF-4G; stimulates\, but is not required for the deadenylation activity of the Pan2p-Pan3p poly\(A\)-ribonuclease complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAB1" EXACT []
synonym: "polyadenylate-binding protein" EXACT []

[Term]
id: sgd:S000000968
name: YER166W
def: "Aminophospholipid translocase \(flippase\); type 4 P-type ATPase; involved in phospholipid translocation\, contributing to endocytosis\, protein transport\, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog\, DNF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNF1" EXACT []
synonym: "aminophospholipid-translocating P4-type ATPase DNF1" EXACT []

[Term]
id: sgd:S000000969
name: YER167W
def: "Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C \(PKC1\) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCK2" EXACT []
synonym: "CTR7" EXACT []

[Term]
id: sgd:S000000970
name: YER168C
def: "ATP \(CTP\)\:tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus\, cytosol\, and mitochondrion are generated via the use of multiple transcriptional and translational start sites" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCA1" EXACT []
synonym: "TNT1" EXACT []

[Term]
id: sgd:S000000971
name: YER169W
def: "JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed \(RNAP II\) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; target of stess-induced hormesis; RPH1 has a paralog\, GIS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KDM4" EXACT []
synonym: "RPH1" EXACT []

[Term]
id: sgd:S000000972
name: YER170W
def: "Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADK2" EXACT []
synonym: "AKY3" EXACT []
synonym: "PAK3" EXACT []
synonym: "adenylate kinase ADK2" EXACT []

[Term]
id: sgd:S000000973
name: YER171W
def: "5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 \(NEF3\); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD3" EXACT []
synonym: "REM1" EXACT []
synonym: "TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3" EXACT []

[Term]
id: sgd:S000000974
name: YER172C
def: "RNA-dependent ATPase RNA helicase \(DEIH box\); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRR2" EXACT []
synonym: "PRP44" EXACT []
synonym: "RSS1" EXACT []
synonym: "SLT22" EXACT []
synonym: "SNU246" EXACT []

[Term]
id: sgd:S000000975
name: YER173W
def: "Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD24" EXACT []
synonym: "RS1" EXACT []

[Term]
id: sgd:S000000976
name: YER174C
def: "Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p\, binds to Aft1p in iron-replete conditions\, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog\, GRX3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX4" EXACT []
synonym: "monothiol glutaredoxin GRX4" EXACT []

[Term]
id: sgd:S000000977
name: YER175C
def: "Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate\, an intermediate of the leucine biosynthetic pathway\, and trans-aconitate\, which inhibits the citric acid cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAM1" EXACT []
synonym: "TMT1" EXACT []

[Term]
id: sgd:S000000978
name: YER176W
def: "DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors\, localized to polysomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM32" EXACT []
synonym: "HEL1" EXACT []
synonym: "MTT1" EXACT []

[Term]
id: sgd:S000000979
name: YER177W
def: "14-3-3 protein\, major isoform; controls proteome at post-transcriptional level\, binds proteins and DNA\, involved in regulation of exocytosis\, vesicle transport\, Ras/MAPK and rapamycin-sensitive signaling\, aggresome formation\, spindle position checkpoint; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; antiapoptotic gene similar to human 14-3-3; BMH1 has a paralog\, BMH2\, that arose from whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "14-3-3 family protein BMH1" EXACT []
synonym: "APR6" EXACT []
synonym: "BMH1" EXACT []

[Term]
id: sgd:S000000980
name: YER178W
def: "E1 alpha subunit of the pyruvate dehydrogenase \(PDH\) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix\, often near the ERMES complex and near peroxisomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDA1" EXACT []
synonym: "pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha" EXACT []

[Term]
id: sgd:S000000981
name: YER179W
def: "Meiosis-specific recombinase required for repair of double-strand breaks; also required for pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA\, forms helical filaments; stimulated by Rdh54p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DMC1" EXACT []
synonym: "ISC2" EXACT []
synonym: "recombinase DMC1" EXACT []

[Term]
id: sgd:S000000982
name: YER180C
def: "Protein required for sporulation; transcript is induced 7.5 hours after induction of meiosis\, expected to play significant role in the formation of reproductive cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISC10" EXACT []

[Term]
id: sgd:S000000983
name: YER181C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000984
name: YER182W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP10" EXACT []

[Term]
id: sgd:S000000985
name: YER183C
def: "5\,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "5-formyltetrahydrofolate cyclo-ligase" EXACT []
synonym: "FAU1" EXACT []

[Term]
id: sgd:S000000986
name: YER184C
def: "Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white\, and prevents growth on glycerol or lactate as sole carbon source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOG1" EXACT []

[Term]
id: sgd:S000000987
name: YER185W
def: "Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter \(LTE\) family of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUG1" EXACT []

[Term]
id: sgd:S000000988
name: YER186C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000989
name: YER187W
def: "Putative protein of unknown function; induced in respiratory-deficient cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000990
name: YER188W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000991
name: YER189W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000992
name: YER190W
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 2" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-2" EXACT []

[Term]
id: sgd:S000000993
name: YHL001W
def: "Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14\, no bacterial homolog; RPL14B has a paralog\, RPL14A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L14B" EXACT []
synonym: "L14e" EXACT []
synonym: "RPL14B" EXACT []
synonym: "ribosomal 60S subunit protein L14B" EXACT []

[Term]
id: sgd:S000000994
name: YHL002W
def: "Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation\, as well as for recycling of Golgi proteins and formation of lumenal membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-0 subunit protein HSE1" EXACT []
synonym: "HSE1" EXACT []

[Term]
id: sgd:S000000995
name: YHL003C
def: "Ceramide synthase component; involved in synthesis of ceramide from C26\(acyl\)-coenzyme A and dihydrosphingosine or phytosphingosine\, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2\, a tumor metastasis suppressor gene whose silencing enahnces invasion/metastasis of prostate cancer cells; LAG1 has a paralog\, LAC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAG1" EXACT []
synonym: "sphingosine N-acyltransferase LAG1" EXACT []

[Term]
id: sgd:S000000996
name: YHL004W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP4" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRP4" EXACT []

[Term]
id: sgd:S000000997
name: YHL005C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000000998
name: YHL006C
def: "Component of Shu complex \(aka PCSS complex\); Shu complex also includes Psy3\, Csm2\, Shu2\, and promotes error-free DNA repair\, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover \(CO\) and non-crossover \(NCO\) pathways of meiotic recombination and formation of Rad51p filaments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHU1" EXACT []

[Term]
id: sgd:S000000999
name: YHL007C
def: "Cdc42p-activated signal transducing kinase; involved in pheromone response\, pseudohyphal/invasive growth\, vacuole inheritance\, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK \(p21-activated kinase\) family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE20" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase kinase STE20" EXACT []

[Term]
id: sgd:S000001000
name: YHL008C
def: "Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001001
name: YHL009C
def: "Basic leucine zipper \(bZIP\) transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP3" EXACT []

[Term]
id: sgd:S000001002
name: YHL010C
def: "Putative protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2\, which is a cytoplasmic protein that binds nuclear localization sequences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRP2" EXACT []
synonym: "ETP1" EXACT []

[Term]
id: sgd:S000001003
name: YHL011C
def: "5-phospho-ribosyl-1\(alpha\)-pyrophosphate synthetase; synthesizes PRPP\, which is required for nucleotide\, histidine\, and tryptophan biosynthesis; one of five related enzymes\, which are active as heteromultimeric complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRS3" EXACT []
synonym: "ribose phosphate diphosphokinase subunit PRS3" EXACT []

[Term]
id: sgd:S000001004
name: YHL012W
def: "Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog\, UGP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP--glucose-1-phosphate uridylyltransferase" EXACT []

[Term]
id: sgd:S000001005
name: YHL013C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; member of the ovarian tumor-like \(OTU\) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OTU2" EXACT []

[Term]
id: sgd:S000001006
name: YHL014C
def: "Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YLF1" EXACT []
synonym: "YLF2" EXACT []

[Term]
id: sgd:S000001007
name: YHL015W
def: "Protein component of the small \(40S\) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS20" EXACT []
synonym: "S10" EXACT []
synonym: "URP2" EXACT []
synonym: "ribosomal 40S subunit protein S20" EXACT []

[Term]
id: sgd:S000001008
name: YHL016C
def: "Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate\, the last intermediate of the allantoin degradative pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUR3" EXACT []

[Term]
id: sgd:S000001009
name: YHL017W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog\, PTM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001010
name: YHL018W
def: "Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4a-hydroxytetrahydrobiopterin dehydratase" EXACT []

[Term]
id: sgd:S000001011
name: YHL019C
def: "Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APM2" EXACT []

[Term]
id: sgd:S000001012
name: YHL020C
def: "Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content\, strongly correlated with overproduction of inositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI1" EXACT []
synonym: "transcriptional regulator OPI1" EXACT []

[Term]
id: sgd:S000001013
name: YHL021C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM17" EXACT []
synonym: "FMP12" EXACT []

[Term]
id: sgd:S000001014
name: YHL022C
def: "Meiosis-specific protein that initiates meiotic recombination; initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO11" EXACT []

[Term]
id: sgd:S000001015
name: YHL023C
def: "Subunit of SEA \(Seh1-associated\)\, Npr2/3\, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex \(Iml1p-Npr2p-Npr3p\) is required for non-nitrogen-starvation \(NNS\)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPR3" EXACT []
synonym: "RMD11" EXACT []

[Term]
id: sgd:S000001016
name: YHL024W
def: "Putative RNA-binding protein; required for the expression of early and middle sporulation genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM4" EXACT []

[Term]
id: sgd:S000001017
name: YHL025W
def: "Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNF6" EXACT []

[Term]
id: sgd:S000001018
name: YHL026C
def: "Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream \(see Locus History\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001019
name: YHL027W
def: "Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM1" EXACT []
synonym: "RIM101" EXACT []
synonym: "alkaline-responsive transcriptional regulator RIM101" EXACT []

[Term]
id: sgd:S000001020
name: YHL028W
def: "Endoplasmic reticulum \(ER\) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WSC4" EXACT []
synonym: "YFW1" EXACT []
synonym: "YHC8" EXACT []

[Term]
id: sgd:S000001021
name: YHL029C
def: "Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA5" EXACT []

[Term]
id: sgd:S000001022
name: YHL030W
def: "Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM29" EXACT []

[Term]
id: sgd:S000001023
name: YHL031C
def: "v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GOS1" EXACT []

[Term]
id: sgd:S000001024
name: YHL032C
def: "Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUT1" EXACT []
synonym: "glycerol kinase" EXACT []

[Term]
id: sgd:S000001025
name: YHL033C
def: "Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A\, no bacterial homolog; RPL8A has a paralog\, RPL8B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L4A" EXACT []
synonym: "L8A" EXACT []
synonym: "L8e" EXACT []
synonym: "MAK7" EXACT []
synonym: "RPL8A" EXACT []
synonym: "YL5" EXACT []
synonym: "ribosomal 60S subunit protein L8A" EXACT []
synonym: "rp6" EXACT []

[Term]
id: sgd:S000001026
name: YHL034C
def: "Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress\, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog\, RNP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SBP1" EXACT []
synonym: "SSB1" EXACT []
synonym: "SSBR1" EXACT []

[Term]
id: sgd:S000001027
name: YHL035C
def: "Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette \(ABC\) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog\, YBT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VMR1" EXACT []
synonym: "putative ATP-binding cassette multidrug transporter VMR1" EXACT []

[Term]
id: sgd:S000001028
name: YHL036W
def: "Low affinity methionine permease; similar to Mup1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUP3" EXACT []

[Term]
id: sgd:S000001029
name: YHL037C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001030
name: YHL038C
def: "Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP2" EXACT []

[Term]
id: sgd:S000001031
name: YHL039W
def: "Lysine methyltransferase; involved in the monomethylation of eEF1A \(Tef1p/Tef2p\); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFM1" EXACT []

[Term]
id: sgd:S000001032
name: YHL040C
def: "ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin\, ferrirhodin\, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARN1" EXACT []

[Term]
id: sgd:S000001033
name: YHL041W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001034
name: YHL042W
def: "Putative protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001035
name: YHL043W
def: "Putative protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM34" EXACT []

[Term]
id: sgd:S000001036
name: YHL044W
def: "Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein \(GFP\)-fusion protein localizes to the plasma membrane in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein" EXACT []

[Term]
id: sgd:S000001037
name: YHL045W
def: "Putative protein of unknown function; not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001038
name: YHL046C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU13" EXACT []
synonym: "seripauperin PAU13" EXACT []

[Term]
id: sgd:S000001039
name: YHL047C
def: "Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARN2" EXACT []
synonym: "TAF1" EXACT []

[Term]
id: sgd:S000001040
name: YHL048W
def: "Nuclear membrane protein; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS8" EXACT []

[Term]
id: sgd:S000001041
name: YHL049C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001042
name: YHL050C
def: "Putative protein of unknown function; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001043
name: YHR001W
def: "Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping\, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog\, OSH6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSH7" EXACT []
synonym: "oxysterol-binding protein related protein OSH7" EXACT []

[Term]
id: sgd:S000001044
name: YHR002W
def: "Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p\, as first hypothesized" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEU5" EXACT []

[Term]
id: sgd:S000001045
name: YHR003C
def: "tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification\, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog\, TCD2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCD1" EXACT []

[Term]
id: sgd:S000001046
name: YHR004C
def: "Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis\, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEM1" EXACT []
synonym: "Nem1-Spo7 phosphatase catalytic subunit NEM1" EXACT []

[Term]
id: sgd:S000001047
name: YHR005C
def: "Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G\(beta\)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC70" EXACT []
synonym: "DAC1" EXACT []
synonym: "GPA1" EXACT []
synonym: "SCG1" EXACT []
synonym: "guanine nucleotide-binding protein subunit alpha" EXACT []

[Term]
id: sgd:S000001048
name: YHR006W
def: "Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog\, STP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STP2" EXACT []

[Term]
id: sgd:S000001049
name: YHR007C
def: "Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4\,4''-dimethyl cholesta-8\,14\,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYP51" EXACT []
synonym: "ERG11" EXACT []
synonym: "sterol 14-demethylase" EXACT []

[Term]
id: sgd:S000001050
name: YHR008C
def: "Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOD2" EXACT []
synonym: "superoxide dismutase SOD2" EXACT []

[Term]
id: sgd:S000001051
name: YHR009C
def: "Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable\, has extended S phase\, and sensitive to expression of top1-T722A allele; similar to human FOXRED1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTN3" EXACT []
synonym: "TDA3" EXACT []

[Term]
id: sgd:S000001052
name: YHR010W
def: "Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27\, no bacterial homolog; RPL27A has a paralog\, RPL27B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L27A" EXACT []
synonym: "L27e" EXACT []
synonym: "RPL27" EXACT []
synonym: "RPL27A" EXACT []
synonym: "ribosomal 60S subunit protein L27A" EXACT []

[Term]
id: sgd:S000001053
name: YHR011W
def: "Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIA4" EXACT []
synonym: "putative serine--tRNA ligase DIA4" EXACT []

[Term]
id: sgd:S000001054
name: YHR012W
def: "Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP11" EXACT []
synonym: "VPS29" EXACT []
synonym: "VPT6" EXACT []

[Term]
id: sgd:S000001055
name: YHR013C
def: "Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p\, Ard1p\, and Nat5p; acetylates many proteins and thus affects telomeric silencing\, cell cycle\, heat-shock resistance\, mating\, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARD1" EXACT []
synonym: "NAA10" EXACT []

[Term]
id: sgd:S000001056
name: YHR014W
def: "Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex \(APC\) substrate that is degraded during anaphase I; expressed only in meiotic cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO13" EXACT []

[Term]
id: sgd:S000001057
name: YHR015W
def: "Putative RNA-binding protein; interacts with Mex67p\, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog\, PES4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIP6" EXACT []

[Term]
id: sgd:S000001058
name: YHR016C
def: "Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog\, LSB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSB4" EXACT []
synonym: "YSC84" EXACT []

[Term]
id: sgd:S000001059
name: YHR017W
def: "Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis\, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSC83" EXACT []

[Term]
id: sgd:S000001060
name: YHR018C
def: "Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG4" EXACT []
synonym: "argininosuccinate lyase ARG4" EXACT []

[Term]
id: sgd:S000001061
name: YHR019C
def: "Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis\, catalyzes the specific attachment of asparagine to its cognate tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DED81" EXACT []
synonym: "asparagine--tRNA ligase DED81" EXACT []

[Term]
id: sgd:S000001062
name: YHR020W
def: "Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain\, but does not possess posttransfer editing activity; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "proline--tRNA ligase" EXACT []

[Term]
id: sgd:S000001063
name: YHR021C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S27\, no bacterial homolog; RPS27B has a paralog\, RPS27A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS27B" EXACT []
synonym: "S27B" EXACT []
synonym: "S27e" EXACT []
synonym: "YS20" EXACT []
synonym: "ribosomal 40S subunit protein S27B" EXACT []
synonym: "rp61" EXACT []

[Term]
id: sgd:S000001064
name: YHR022C
def: "Putative protein of unknown function; YHR022C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001065
name: YHR023W
def: "Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MYO1" EXACT []
synonym: "myosin 1" EXACT []

[Term]
id: sgd:S000001066
name: YHR024C
def: "Alpha subunit of the mitochondrial processing protease \(MPP\); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS2" EXACT []
synonym: "MIF2" EXACT []

[Term]
id: sgd:S000001067
name: YHR025W
def: "Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THR1" EXACT []
synonym: "homoserine kinase" EXACT []

[Term]
id: sgd:S000001068
name: YHR026W
def: "Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V0 sector ATPase subunit c''" EXACT []
synonym: "PPA1" EXACT []
synonym: "VMA16" EXACT []

[Term]
id: sgd:S000001069
name: YHR027C
def: "Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat \(LRR\) domain\, a site for protein-protein interactions; RP is the acronym for regulatory particle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRD2" EXACT []
synonym: "NAS1" EXACT []
synonym: "RPN1" EXACT []
synonym: "proteasome regulatory particle base subunit RPN1" EXACT []

[Term]
id: sgd:S000001070
name: YHR028C
def: "Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAP2" EXACT []
synonym: "DPP2" EXACT []

[Term]
id: sgd:S000001071
name: YHR029C
def: "Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily\, though most likely not involved in phenazine production" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YHI9" EXACT []

[Term]
id: sgd:S000001072
name: YHR030C
def: "Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity\, cell cycle progression\, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to phagophore assembly site \(PAS\); plays a role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; SLT2 has a paralog\, KDX1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BYC2" EXACT []
synonym: "LYT2" EXACT []
synonym: "MPK1" EXACT []
synonym: "SLK2" EXACT []
synonym: "SLT2" EXACT []
synonym: "mitogen-activated serine/threonine-protein kinase SLT2" EXACT []

[Term]
id: sgd:S000001073
name: YHR031C
def: "DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRM3" EXACT []
synonym: "RTT104" EXACT []

[Term]
id: sgd:S000001074
name: YHR032W
def: "Member of the multi-drug and toxin extrusion \(MATE\) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide \(MOP\) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERC1" EXACT []

[Term]
id: sgd:S000001075
name: YHR033W
def: "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog\, PRO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative glutamate 5-kinase" EXACT []

[Term]
id: sgd:S000001076
name: YHR034C
def: "Component of the conserved R2TP complex \(Rvb1-Rvb2-Tah1-Pih1\); R2TP complex interacts with Hsp90 \(Hsp82p and Hsc82p\) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP17" EXACT []
synonym: "PIH1" EXACT []

[Term]
id: sgd:S000001077
name: YHR035W
def: "Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEL1" EXACT []

[Term]
id: sgd:S000001078
name: YHR036W
def: "Essential nuclear envelope integral membrane protein; identified as a suppressor of a conditional mutation in the major karyopherin\, CRM1; homologous to and interacts with Brr6p\, a nuclear envelope protein involved in nuclear export" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRL1" EXACT []

[Term]
id: sgd:S000001079
name: YHR037W
def: "Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog ALDH4A1 causes type II hyperprolinemia \(HPII\)\, an autosomal recessive inborn error of metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-pyrroline-5-carboxylate dehydrogenase" EXACT []
synonym: "PUT2" EXACT []

[Term]
id: sgd:S000001080
name: YHR038W
def: "Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIL1" EXACT []
synonym: "KIM4" EXACT []
synonym: "RRF1" EXACT []

[Term]
id: sgd:S000001081
name: YHR039C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSC7" EXACT []

[Term]
id: sgd:S000001082
name: YHR040W
def: "Essential protein required for the accumulation of box C/D snoRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCD1" EXACT []

[Term]
id: sgd:S000001083
name: YHR041C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRS2" EXACT []
synonym: "MED20" EXACT []
synonym: "SRB2" EXACT []

[Term]
id: sgd:S000001084
name: YHR042W
def: "NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR1" EXACT []
synonym: "NCP1" EXACT []

[Term]
id: sgd:S000001085
name: YHR043C
def: "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases\, induced by oxidative and osmotic stress\, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog\, DOG1\, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae\, S. paradoxus\, and S. mikatae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOG2" EXACT []

[Term]
id: sgd:S000001086
name: YHR044C
def: "2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog\, DOG2\, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae\, S. paradoxus\, and S. mikatae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOG1" EXACT []

[Term]
id: sgd:S000001087
name: YHR045W
def: "Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001088
name: YHR046C
def: "Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INM1" EXACT []
synonym: "inositol monophosphate 1-phosphatase INM1" EXACT []

[Term]
id: sgd:S000001089
name: YHR047C
def: "Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog\, APE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAP1" EXACT []
synonym: "AAP1'" EXACT []

[Term]
id: sgd:S000001090
name: YHR048W
def: "Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YHK8" EXACT []

[Term]
id: sgd:S000001091
name: YHR049W
def: "Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FSH1" EXACT []

[Term]
id: sgd:S000001092
name: YHR050W
def: "Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMF2" EXACT []
synonym: "divalent metal ion transporter SMF2" EXACT []

[Term]
id: sgd:S000001093
name: YHR051W
def: "Subunit VI of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX6" EXACT []
synonym: "cytochrome c oxidase subunit VI" EXACT []

[Term]
id: sgd:S000001094
name: YHR052W
def: "Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIC1" EXACT []
synonym: "NSA3" EXACT []

[Term]
id: sgd:S000001095
name: YHR053C
def: "Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains\, with two copies\, CUP1-1 and CUP1-2\, in the genomic sequence reference strain S288C; CUP1-1 has a paralog\, CUP1-2\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUP1" EXACT []
synonym: "CUP1-1" EXACT []
synonym: "metallothionein CUP1" EXACT []

[Term]
id: sgd:S000001096
name: YHR054C
def: "Putative protein of unknown function; partial duplicate of RSC30/YHR056C\, truncated remnant of segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001097
name: YHR055C
def: "Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains\, with two copies\, CUP1-1 and CUP1-2\, in the genomic sequence reference strain S288C; CUP1-2 has a paralog\, CUP1-1\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUP1" EXACT []
synonym: "CUP1-2" EXACT []
synonym: "metallothionein CUP1" EXACT []

[Term]
id: sgd:S000001098
name: YHR056C
def: "Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog\, RSC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC30" EXACT []

[Term]
id: sgd:S000001099
name: YHR057C
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR2 has a paralog\, CPR5\, that arose from the whole genome duplication; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR2" EXACT []
synonym: "CYP2" EXACT []
synonym: "peptidylprolyl isomerase CPR2" EXACT []

[Term]
id: sgd:S000001100
name: YHR058C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED6" EXACT []

[Term]
id: sgd:S000001101
name: YHR059W
def: "Protein of unknown function; required for survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV4" EXACT []

[Term]
id: sgd:S000001102
name: YHR060W
def: "Protein that is required for vacuolar H+-ATPase \(V-ATPase\) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum \(ER\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEV1" EXACT []
synonym: "VMA22" EXACT []
synonym: "VPH6" EXACT []

[Term]
id: sgd:S000001103
name: YHR061C
def: "Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding \(CRIB\) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog\, GIC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIC1" EXACT []

[Term]
id: sgd:S000001104
name: YHR062C
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPP1" EXACT []

[Term]
id: sgd:S000001105
name: YHR063C
def: "2-dehydropantoate 2-reductase; part of the pantothenic acid pathway\, structurally homologous to E. coli panE" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-dehydropantoate 2-reductase PAN5" EXACT []
synonym: "PAN5" EXACT []

[Term]
id: sgd:S000001106
name: YHR064C
def: "Hsp70 protein that interacts with Zuo1p \(a DnaJ homolog\); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDR13" EXACT []
synonym: "SSZ1" EXACT []

[Term]
id: sgd:S000001107
name: YHR065C
def: "Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a\, which is a DEAD box RNA-dependent ATPase with helicase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA-dependent ATPase RRP3" EXACT []
synonym: "RRP3" EXACT []

[Term]
id: sgd:S000001108
name: YHR066W
def: "Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog\, SSF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSF1" EXACT []

[Term]
id: sgd:S000001109
name: YHR067W
def: "Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis\, required for respiratory growth and for normal mitochondrial morphology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTD2" EXACT []
synonym: "RMD12" EXACT []
synonym: "hydroxyacyl-thioester dehydratase HTD2" EXACT []

[Term]
id: sgd:S000001110
name: YHR068W
def: "Deoxyhypusine synthase; catalyzes formation of deoxyhypusine\, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DYS1" EXACT []

[Term]
id: sgd:S000001111
name: YHR069C
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p \(EXOSC2\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP4" EXACT []

[Term]
id: sgd:S000001112
name: YHR070W
def: "tRNA\(m\(1\)G37\)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea\, Bacteria\, and Eukarya" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM5" EXACT []

[Term]
id: sgd:S000001113
name: YHR071W
def: "Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase \(Cdk\)\, induced by Gcn4p at level of transcription\, specifically required for Gcn4p degradation\, may be sensor of cellular protein biosynthetic capacity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL5" EXACT []

[Term]
id: sgd:S000001114
name: YHR072W
def: "Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2\,3-epoxide\, a step in ergosterol biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG7" EXACT []
synonym: "lanosterol synthase ERG7" EXACT []

[Term]
id: sgd:S000001115
name: YHR073W
def: "Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping\, redundant functions in sterol metabolism and collectively perform a function essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSH3" EXACT []
synonym: "oxysterol-binding protein related protein OSH3" EXACT []

[Term]
id: sgd:S000001116
name: YHR074W
def: "Glutamine-dependent NAD\(+\) synthetase; essential for the formation of NAD\(+\) from nicotinic acid adenine dinucleotide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QNS1" EXACT []
synonym: "glutamine-dependent NAD(+) synthetase" EXACT []

[Term]
id: sgd:S000001117
name: YHR075C
def: "Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS2" EXACT []
synonym: "PPE1" EXACT []
synonym: "YmS2" EXACT []
synonym: "carboxylesterase-mitochondrial 37S ribosomal protein YmS2" EXACT []

[Term]
id: sgd:S000001118
name: YHR076W
def: "Type 2C serine/threonine protein phosphatase \(PP2C\); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTC7" EXACT []
synonym: "type 2C protein phosphatase PTC7" EXACT []

[Term]
id: sgd:S000001119
name: YHR077C
def: "Protein involved in the nonsense-mediated mRNA decay \(NMD\) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IFS1" EXACT []
synonym: "NMD2" EXACT []
synonym: "SUA1" EXACT []
synonym: "SUP111" EXACT []
synonym: "UPF2" EXACT []

[Term]
id: sgd:S000001120
name: YHR078W
def: "High osmolarity-regulated gene of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001121
name: YHR079C
def: "Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response \(UPR\) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERN1" EXACT []
synonym: "IRE1" EXACT []
synonym: "bifunctional endoribonuclease/protein kinase IRE1" EXACT []

[Term]
id: sgd:S000001122
name: YHR080C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; may have a role in intracellular sterol transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001123
name: YHR081W
def: "Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing\, surveillance\, degradation\, tethering\, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LRP1" EXACT []
synonym: "RRP47" EXACT []
synonym: "YC1D" EXACT []

[Term]
id: sgd:S000001124
name: YHR082C
def: "Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p\, Fus3p\, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KSP1" EXACT []
synonym: "putative serine/threonine protein kinase KSP1" EXACT []

[Term]
id: sgd:S000001125
name: YHR083W
def: "Component of the sorting and assembly machinery \(SAM\) complex; the SAM \(or TOB\) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP20" EXACT []
synonym: "SAM complex subunit SAM35" EXACT []
synonym: "SAM35" EXACT []
synonym: "TOB38" EXACT []
synonym: "TOM38" EXACT []

[Term]
id: sgd:S000001126
name: YHR084W
def: "Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE12" EXACT []
synonym: "homeodomain family transcription factor STE12" EXACT []

[Term]
id: sgd:S000001127
name: YHR085W
def: "Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex \(pre-RC\) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPI1" EXACT []

[Term]
id: sgd:S000001128
name: YHR086W
def: "RNA binding protein\, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores\, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107\, HFM1\, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRE2" EXACT []
synonym: "MUD15" EXACT []
synonym: "NAM8" EXACT []

[Term]
id: sgd:S000001129
name: YHR087W
def: "Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS\, the human protein mutated in Shwachman-Diamond Syndrome \(the yeast SBDS ortholog = SDO1\); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HGI1" EXACT []
synonym: "RTC3" EXACT []

[Term]
id: sgd:S000001130
name: YHR088W
def: "Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma\(70\)-like motif\, which is thought to bind RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPF1" EXACT []

[Term]
id: sgd:S000001131
name: YHR089C
def: "Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAR1" EXACT []
synonym: "H/ACA snoRNP pseudouridylase subunit GAR1" EXACT []

[Term]
id: sgd:S000001132
name: YHR090C
def: "Subunit of NuA4\, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF4" EXACT []
synonym: "NBN1" EXACT []
synonym: "YNG2" EXACT []
synonym: "histone acetyltransferase YNG2" EXACT []

[Term]
id: sgd:S000001133
name: YHR091C
def: "Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog\, YDR341C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSR1" EXACT []
synonym: "arginine--tRNA ligase MSR1" EXACT []

[Term]
id: sgd:S000001134
name: YHR092C
def: "High-affinity glucose transporter; member of the major facilitator superfamily\, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog\, HXT7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT4" EXACT []
synonym: "LGT1" EXACT []
synonym: "RAG1" EXACT []
synonym: "hexose transporter HXT4" EXACT []

[Term]
id: sgd:S000001135
name: YHR093W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects\, likely due to the presence of an HXT4 regulatory element in the region" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AHT1" EXACT []

[Term]
id: sgd:S000001136
name: YHR094C
def: "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog\, HXT6\, what arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOR4" EXACT []
synonym: "HXT1" EXACT []
synonym: "hexose transporter HXT1" EXACT []

[Term]
id: sgd:S000001137
name: YHR095W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001138
name: YHR096C
def: "Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources\, induced by a decrease in growth rate\, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog\, HXT3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT5" EXACT []
synonym: "hexose transporter HXT5" EXACT []

[Term]
id: sgd:S000001139
name: YHR097C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog\, PAL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001140
name: YHR098C
def: "Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LST1" EXACT []
synonym: "SFB3" EXACT []

[Term]
id: sgd:S000001141
name: YHR099W
def: "Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators \(e.g.\, Gal4p\) which leads to transcription activation; similar to human TRRAP\, which is a cofactor for c-Myc mediated oncogenic transformation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRA1" EXACT []
synonym: "histone acetyltransferase TRA1" EXACT []

[Term]
id: sgd:S000001142
name: YHR100C
def: "Mitochondrial phosphatidylglycerophosphatase \(PGP phosphatase\); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol\, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin\, DTT" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEP4" EXACT []

[Term]
id: sgd:S000001143
name: YHR101C
def: "Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1\,6-glucan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIG1" EXACT []

[Term]
id: sgd:S000001144
name: YHR102W
def: "Protein kinase of the PAK/Ste20 family\, required for cell integrity; physically interacts with Cdc31p \(centrin\)\, which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIC1" EXACT []
synonym: "NRK1" EXACT []
synonym: "putative serine/threonine protein kinase KIC1" EXACT []

[Term]
id: sgd:S000001145
name: YHR103W
def: "Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog\, SBE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SBE22" EXACT []

[Term]
id: sgd:S000001146
name: YHR104W
def: "Aldose reductase; involved in methylglyoxal\, d-xylose\, arabinose\, and galactose metabolism; stress induced \(osmotic\, ionic\, oxidative\, heat shock\, starvation and heavy metals\); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRE3" EXACT []
synonym: "trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))" EXACT []

[Term]
id: sgd:S000001147
name: YHR105W
def: "Endosomal protein of unknown function; contains a phox \(PX\) homology domain; binds to both phosphatidylinositol-3-phosphate \(PtdIns\(3\)P\) and proteins involved in ER-Golgi or vesicular transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPT35" EXACT []

[Term]
id: sgd:S000001148
name: YHR106W
def: "Mitochondrial thioredoxin reductase; involved in protection against oxidative stress\, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif \(CAVC\) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog\, TRR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRR2" EXACT []
synonym: "thioredoxin-disulfide reductase TRR2" EXACT []

[Term]
id: sgd:S000001149
name: YHR107C
def: "Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC12" EXACT []
synonym: "CLA10" EXACT []
synonym: "PSL7" EXACT []
synonym: "septin CDC12" EXACT []

[Term]
id: sgd:S000001150
name: YHR108W
def: "Protein that regulates Arf1p\, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate\, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog\, GGA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GGA2" EXACT []

[Term]
id: sgd:S000001151
name: YHR109W
def: "Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c \(Cyc1p\) in the cytosol; not required for normal respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTM1" EXACT []

[Term]
id: sgd:S000001152
name: YHR110W
def: "Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP5" EXACT []

[Term]
id: sgd:S000001153
name: YHR111W
def: "E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBA4" EXACT []
synonym: "YHR1" EXACT []

[Term]
id: sgd:S000001154
name: YHR112C
def: "Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative cystathionine beta-lyase" EXACT []

[Term]
id: sgd:S000001155
name: YHR113W
def: "Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APE4" EXACT []

[Term]
id: sgd:S000001156
name: YHR114W
def: "SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BZZ1" EXACT []
synonym: "LSB7" EXACT []

[Term]
id: sgd:S000001157
name: YHR115C
def: "Ubiquitin-protein ligase \(E3\); controls septin dynamics\, spindle position checkpoint \(SPOC\) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p\, as well as abundance\, localization\, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8\, similar to human Chfr; contains FHA\, RING fingers; DMA1 has a paralog\, DMA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHF1" EXACT []
synonym: "DMA1" EXACT []
synonym: "ubiquitin-conjugating protein DMA1" EXACT []

[Term]
id: sgd:S000001158
name: YHR116W
def: "Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX23" EXACT []

[Term]
id: sgd:S000001159
name: YHR117W
def: "Mitochondrial outer membrane protein; probable minor component of the TOM \(translocase of outer membrane\) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog\, TOM70\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOM71" EXACT []
synonym: "TOM72" EXACT []
synonym: "protein channel TOM71" EXACT []

[Term]
id: sgd:S000001160
name: YHR118C
def: "Subunit of the origin recognition complex \(ORC\); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC6" EXACT []
synonym: "origin recognition complex subunit 6" EXACT []

[Term]
id: sgd:S000001161
name: YHR119W
def: "Histone methyltransferase\, subunit of the COMPASS \(Set1C\) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p\, allowing efficient termination of snoRNAs and cryptic unstable transcripts \(CUTs\) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KMT2" EXACT []
synonym: "SET1" EXACT []
synonym: "YTX1" EXACT []
synonym: "histone methyltransferase SET1" EXACT []

[Term]
id: sgd:S000001162
name: YHR120W
def: "DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH1" EXACT []
synonym: "mismatch repair ATPase MSH1" EXACT []

[Term]
id: sgd:S000001163
name: YHR121W
def: "Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM12" EXACT []

[Term]
id: sgd:S000001164
name: YHR122W
def: "Component of cytosolic iron-sulfur protein assembly \(CIA\) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis\, DNA replication and repair\, transcription\, and telomere maintenance; ortholog of human FAM96B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIA2" EXACT []

[Term]
id: sgd:S000001165
name: YHR123W
def: "sn-1\,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog\, CPT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPT1" EXACT []
synonym: "bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase" EXACT []

[Term]
id: sgd:S000001166
name: YHR124W
def: "Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements \(MSE\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDT80" EXACT []
synonym: "transcription factor NDT80" EXACT []

[Term]
id: sgd:S000001167
name: YHR125W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001168
name: YHR126C
def: "Putative GPI protein; transcription dependent upon Azf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANS1" EXACT []

[Term]
id: sgd:S000001169
name: YHR127W
def: "Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSN1" EXACT []

[Term]
id: sgd:S000001170
name: YHR128W
def: "Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUR1" EXACT []
synonym: "uracil phosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000001171
name: YHR129C
def: "Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACT5" EXACT []
synonym: "ARP1" EXACT []
synonym: "actin-related protein 1" EXACT []

[Term]
id: sgd:S000001172
name: YHR130C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001173
name: YHR131C
def: "Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog\, YNL144C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001174
name: YHR132C
def: "Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM14" EXACT []

[Term]
id: sgd:S000001175
name: YHR133C
def: "Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p\, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog\, NSG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSG1" EXACT []

[Term]
id: sgd:S000001176
name: YHR134W
def: "Metalloprotease involved in DNA repair\, removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; sumoylated protein localizing to the nuclear periphery of mother cells; localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; activated by DNA binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WSS1" EXACT []

[Term]
id: sgd:S000001177
name: YHR135C
def: "Palmitoylated plasma membrane-bound casein kinase I \(CK1\) isoform; shares redundant functions with Yck2p in morphogenesis\, proper septin assembly\, endocytic trafficking\, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen\, causing glucose repression of respiratory metabolism; YCK1 has a paralog\, YCK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKI2" EXACT []
synonym: "YCK1" EXACT []
synonym: "serine/threonine protein kinase YCK1" EXACT []

[Term]
id: sgd:S000001178
name: YHR136C
def: "Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element \(HRE\) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPL2" EXACT []

[Term]
id: sgd:S000001179
name: YHR137W
def: "Aromatic aminotransferase II; catalyzes the first step of tryptophan\, phenylalanine\, and tyrosine catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO9" EXACT []
synonym: "aromatic-amino-acid:2-oxoglutarate transaminase" EXACT []

[Term]
id: sgd:S000001180
name: YHR138C
def: "Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001181
name: YHR139C
def: "Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog\, YGP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS100" EXACT []

[Term]
id: sgd:S000001182
name: YHR140W
def: "Putative integral membrane protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001183
name: YHR141C
def: "Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A\, no bacterial homolog; RPL42B has a paralog\, RPL42A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L41B" EXACT []
synonym: "L42B" EXACT []
synonym: "L44e" EXACT []
synonym: "MAK18" EXACT []
synonym: "RPL42B" EXACT []
synonym: "YL27" EXACT []
synonym: "YP44" EXACT []
synonym: "ribosomal 60S subunit protein L42B" EXACT []

[Term]
id: sgd:S000001184
name: YHR142W
def: "Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHS7" EXACT []

[Term]
id: sgd:S000001185
name: YHR143W-A
def: "RNA polymerase subunit ABC10-alpha\, found in RNA pol I\, II\, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC10-alpha" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPB12" EXACT []
synonym: "RPB12" EXACT []
synonym: "RPC10" EXACT []

[Term]
id: sgd:S000001186
name: YHR143W
def: "Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSE2" EXACT []

[Term]
id: sgd:S000001187
name: YHR144C
def: "Deoxycytidine monophosphate \(dCMP\) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCD1" EXACT []

[Term]
id: sgd:S000001188
name: YHR145C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001189
name: YHR146W
def: "Protein that binds to cruciform DNA structures; CRP1 has a paralog\, MDG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRP1" EXACT []

[Term]
id: sgd:S000001190
name: YHR147C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL6" EXACT []
synonym: "YmL16" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL16" EXACT []

[Term]
id: sgd:S000001191
name: YHR148W
def: "Component of the SSU processome; SSU processome is required for pre-18S rRNA processing\, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP3" EXACT []

[Term]
id: sgd:S000001192
name: YHR149C
def: "Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog\, TOS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKG6" EXACT []

[Term]
id: sgd:S000001193
name: YHR150W
def: "Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size\, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p\, Pex31p\, and Pex32p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX28" EXACT []

[Term]
id: sgd:S000001194
name: YHR151C
def: "Protein of unknown function; mtc6 is synthetically sick with cdc13-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC6" EXACT []

[Term]
id: sgd:S000001195
name: YHR152W
def: "Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase\, may play similar role in meiosis; SPO12 has a paralog\, BNS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDB21" EXACT []
synonym: "SPO12" EXACT []

[Term]
id: sgd:S000001196
name: YHR153C
def: "Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO16" EXACT []

[Term]
id: sgd:S000001197
name: YHR154W
def: "Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESC4" EXACT []
synonym: "RTT107" EXACT []

[Term]
id: sgd:S000001198
name: YHR155W
def: "Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog\, SIP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSP1" EXACT []

[Term]
id: sgd:S000001199
name: YHR156C
def: "Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation\, mRNA splicing and DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIN1" EXACT []
synonym: "SNU40" EXACT []

[Term]
id: sgd:S000001200
name: YHR157W
def: "Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REC104" EXACT []

[Term]
id: sgd:S000001201
name: YHR158C
def: "Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit\, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL1 has a paralog\, KEL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEL1" EXACT []

[Term]
id: sgd:S000001202
name: YHR159W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA11" EXACT []

[Term]
id: sgd:S000001203
name: YHR160C
def: "Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; PEX18 has a paralog\, PEX21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX18" EXACT []

[Term]
id: sgd:S000001204
name: YHR161C
def: "Protein of the AP180 family\, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog\, YAP1802\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP1801" EXACT []

[Term]
id: sgd:S000001205
name: YHR162W
def: "Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Mpc1p and either Mpc2p or Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; MPC2 has a paralog\, FMP43\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPC2" EXACT []

[Term]
id: sgd:S000001206
name: YHR163W
def: "6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog\, SOL4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-phosphogluconolactonase SOL3" EXACT []
synonym: "SOL3" EXACT []

[Term]
id: sgd:S000001207
name: YHR164C
def: "Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase\, ATP-dependent nuclease\, and helicase activities; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair and processing of meiotic DNA double strand breaks; required for normal life span; component of telomeric chromatin\, with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA2" EXACT []
synonym: "WEB2" EXACT []
synonym: "bifuctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2" EXACT []

[Term]
id: sgd:S000001208
name: YHR165C
def: "Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in its human ortholog\, PRPF8\, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBF3" EXACT []
synonym: "DNA39" EXACT []
synonym: "PRP8" EXACT []
synonym: "RNA8" EXACT []
synonym: "SLT21" EXACT []
synonym: "U4/U6-U5 snRNP complex component PRP8" EXACT []
synonym: "USA2" EXACT []

[Term]
id: sgd:S000001209
name: YHR166C
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC23" EXACT []
synonym: "anaphase promoting complex subunit CDC23" EXACT []

[Term]
id: sgd:S000001210
name: YHR167W
def: "Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination\, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THP2" EXACT []

[Term]
id: sgd:S000001211
name: YHR168W
def: "Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation\, possibly via a role in ribosome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTG2" EXACT []
synonym: "putative GTPase MTG2" EXACT []

[Term]
id: sgd:S000001212
name: YHR169W
def: "ATPase\, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase DBP8" EXACT []
synonym: "DBP8" EXACT []

[Term]
id: sgd:S000001213
name: YHR170W
def: "Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NMD3" EXACT []
synonym: "SRC5" EXACT []
synonym: "ribosome-binding protein NMD3" EXACT []

[Term]
id: sgd:S000001214
name: YHR171W
def: "Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG11" EXACT []
synonym: "APG7" EXACT []
synonym: "ATG7" EXACT []
synonym: "CVT2" EXACT []

[Term]
id: sgd:S000001215
name: YHR172W
def: "Component of the microtubule-nucleating Tub4p \(gamma-tubulin\) complex; interacts with Spc110p at the spindle pole body \(SPB\) inner plaque and with Spc72p at the SPB outer plaque" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC97" EXACT []

[Term]
id: sgd:S000001216
name: YHR173C
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001217
name: YHR174W
def: "Enolase II\, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression induced in response to glucose; ENO2 has a paralog\, ENO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENO2" EXACT []
synonym: "phosphopyruvate hydratase ENO2" EXACT []

[Term]
id: sgd:S000001218
name: YHR175W
def: "Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations\, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTR2" EXACT []

[Term]
id: sgd:S000001219
name: YHR176W
def: "Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMO1" EXACT []

[Term]
id: sgd:S000001220
name: YHR177W
def: "Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GON3" EXACT []

[Term]
id: sgd:S000001221
name: YHR178W
def: "Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn\(II\)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB5" EXACT []

[Term]
id: sgd:S000001222
name: YHR179W
def: "Conserved NADPH oxidoreductase containing flavin mononucleotide \(FMN\); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism\, oxidative stress response\, and programmed cell death; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OYE2" EXACT []

[Term]
id: sgd:S000001223
name: YHR180W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001224
name: YHR181W
def: "Integral membrane protein of the early Golgi apparatus and ER; involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV26" EXACT []
synonym: "SVP26" EXACT []

[Term]
id: sgd:S000001225
name: YHR182W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001226
name: YHR183W
def: "6-phosphogluconate dehydrogenase \(decarboxylating\); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog\, GND2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GND1" EXACT []
synonym: "phosphogluconate dehydrogenase (decarboxylating) GND1" EXACT []

[Term]
id: sgd:S000001227
name: YHR184W
def: "Protein involved in the control of meiotic nuclear division; also involved in the coordination of meiosis with spore formation; transcription is induced midway through meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO3" EXACT []
synonym: "SSP1" EXACT []

[Term]
id: sgd:S000001228
name: YHR185C
def: "Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADY1" EXACT []
synonym: "PFS1" EXACT []

[Term]
id: sgd:S000001229
name: YHR186C
def: "Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p\, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KOG1" EXACT []
synonym: "LAS24" EXACT []

[Term]
id: sgd:S000001230
name: YHR187W
def: "Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP5" EXACT []
synonym: "Elongator subunit IKI1" EXACT []
synonym: "HAP2" EXACT []
synonym: "IKI1" EXACT []
synonym: "TOT5" EXACT []

[Term]
id: sgd:S000001231
name: YHR188C
def: "Subunit of the glycosylphosphatidylinositol transamidase complex; transmembrane protein; adds GPIs to newly synthesized proteins; human PIG-Tp homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI16" EXACT []

[Term]
id: sgd:S000001232
name: YHR189W
def: "One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium\, but required for respiratory growth on minimal medium; see also PTH2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTH" EXACT []
synonym: "PTH1" EXACT []

[Term]
id: sgd:S000001233
name: YHR190W
def: "Farnesyl-diphosphate farnesyl transferase \(squalene synthase\); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG9" EXACT []
synonym: "bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase" EXACT []

[Term]
id: sgd:S000001234
name: YHR191C
def: "Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTF8" EXACT []

[Term]
id: sgd:S000001235
name: YHR192W
def: "Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LNP1" EXACT []

[Term]
id: sgd:S000001236
name: YHR193C
def: "Alpha subunit of the nascent polypeptide-associated complex \(NAC\); involved in protein sorting and translocation; associated with cytoplasmic ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGD2" EXACT []

[Term]
id: sgd:S000001237
name: YHR194W
def: "Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1\, MMM2\, MDM10\, MDM12\, and MDM34" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM31" EXACT []

[Term]
id: sgd:S000001238
name: YHR195W
def: "Nuclear envelope protein; anchored to the nuclear inner membrane\, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus \(PMN\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NVJ1" EXACT []
synonym: "VAB36" EXACT []

[Term]
id: sgd:S000001239
name: YHR196W
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP9" EXACT []

[Term]
id: sgd:S000001240
name: YHR197W
def: "Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex \(pre-RC\) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPI2" EXACT []
synonym: "RIX1" EXACT []

[Term]
id: sgd:S000001241
name: YHR198C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM18" EXACT []
synonym: "FMP22" EXACT []

[Term]
id: sgd:S000001242
name: YHR199C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM46" EXACT []
synonym: "FMP34" EXACT []

[Term]
id: sgd:S000001243
name: YHR200W
def: "Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle \(RP\); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCB1" EXACT []
synonym: "RPN10" EXACT []
synonym: "SUN1" EXACT []
synonym: "proteasome regulatory particle base subunit RPN10" EXACT []

[Term]
id: sgd:S000001244
name: YHR201C
def: "Exopolyphosphatase; hydrolyzes inorganic polyphosphate \(poly P\) into Pi residues; located in the cytosol\, plasma membrane\, and mitochondrial matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPX1" EXACT []

[Term]
id: sgd:S000001245
name: YHR202W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole\, while HA-tagged protein is found in the soluble fraction\, suggesting cytoplasmic localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001246
name: YHR203C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S4\, no bacterial homolog; RPS4B has a paralog\, RPS4A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS4B" EXACT []
synonym: "S4B" EXACT []
synonym: "S4e" EXACT []
synonym: "S7B" EXACT []
synonym: "YS6" EXACT []
synonym: "ribosomal 40S subunit protein S4B" EXACT []
synonym: "rp5" EXACT []

[Term]
id: sgd:S000001247
name: YHR204W
def: "Alpha-1\,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p\, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-mannosidase MNL1" EXACT []
synonym: "HTM1" EXACT []
synonym: "MNL1" EXACT []
synonym: "alpha-1" EXACT []

[Term]
id: sgd:S000001248
name: YHR205W
def: "AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis\, translation initiation\, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression\, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRM2" EXACT []
synonym: "KOM1" EXACT []
synonym: "SCH9" EXACT []
synonym: "serine/threonine protein kinase SCH9" EXACT []

[Term]
id: sgd:S000001249
name: YHR206W
def: "Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog\, HMS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRY1" EXACT []
synonym: "POS9" EXACT []
synonym: "SKN7" EXACT []
synonym: "kinase-regulated stress-responsive transcription factor SKN7" EXACT []

[Term]
id: sgd:S000001250
name: YHR207C
def: "Methyltransferase involved in methylation of histone H4 Lys5\, -8\, -12; S-adenosylmethionine-dependent; zinc-finger protein\, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SET5" EXACT []

[Term]
id: sgd:S000001251
name: YHR208W
def: "Mitochondrial branched-chain amino acid \(BCAA\) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog\, BAT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAT1" EXACT []
synonym: "ECA39" EXACT []
synonym: "TWT1" EXACT []
synonym: "branched-chain-amino-acid transaminase BAT1" EXACT []

[Term]
id: sgd:S000001252
name: YHR209W
def: "S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRG1" EXACT []

[Term]
id: sgd:S000001253
name: YHR210C
def: "Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "aldose 1-epimerase superfamily protein" EXACT []

[Term]
id: sgd:S000001254
name: YHR211W
def: "Lectin-like cell wall protein \(flocculin\) involved in flocculation; binds mannose chains on the surface of other cells\, confers floc-forming ability that is chymotrypsin resistant but heat labile; FLO5 has a paralog\, FLO1\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLO5" EXACT []
synonym: "flocculin FLO5" EXACT []

[Term]
id: sgd:S000001255
name: YHR212C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YHR212C has a paralog\, YAR060C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001256
name: YHR213W
def: "Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog\, YAR062W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001257
name: YHR214W
def: "Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified \(GPI\) protein; YHR214W has a paralog\, YAR066W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001258
name: YHR215W
def: "One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog\, PHO11\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO10" EXACT []
synonym: "PHO12" EXACT []
synonym: "acid phosphatase PHO12" EXACT []

[Term]
id: sgd:S000001259
name: YHR216W
def: "Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis\, expression is induced by mycophenolic acid resulting in resistance to the drug\, expression is repressed by nutrient limitation; IMD2 has a paralog\, YAR073W/YAR075W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMD2" EXACT []
synonym: "IMP dehydrogenase IMD2" EXACT []
synonym: "PUR5" EXACT []

[Term]
id: sgd:S000001260
name: YHR217C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; located in the telomeric region TEL08R" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001261
name: YHR218W
def: "Helicase-like protein encoded within the telomeric Y' element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001262
name: YHR219W
def: "Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001263
name: YIL001W
def: "Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001264
name: YIL002C
def: "Phosphatidylinositol 4\,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain\, plays a role in phosphatidylinositol 4\,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP51" EXACT []
synonym: "SJL1" EXACT []
synonym: "phosphoinositide 5-phosphatase INP51" EXACT []

[Term]
id: sgd:S000001265
name: YIL003W
def: "Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CFD1" EXACT []
synonym: "DRE3" EXACT []

[Term]
id: sgd:S000001266
name: YIL004C
def: "Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BET1" EXACT []
synonym: "SLY12" EXACT []

[Term]
id: sgd:S000001267
name: YIL005W
def: "ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation \(ERAD\)\, member of the protein disulfide isomerase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPS1" EXACT []
synonym: "protein disulfide isomerase EPS1" EXACT []

[Term]
id: sgd:S000001268
name: YIL006W
def: "Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria \(see also YEA6\); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog\, YEA6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDT1" EXACT []
synonym: "YIA6" EXACT []

[Term]
id: sgd:S000001269
name: YIL007C
def: "Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle \(RP\); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAS2" EXACT []

[Term]
id: sgd:S000001270
name: YIL008W
def: "Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URM1" EXACT []
synonym: "ubiquitin-related modifier URM1" EXACT []

[Term]
id: sgd:S000001271
name: YIL009W
def: "Long chain fatty acyl-CoA synthetase; activates imported fatty acids; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAA3" EXACT []
synonym: "long-chain fatty acid-CoA ligase FAA3" EXACT []

[Term]
id: sgd:S000001272
name: YIL010W
def: "Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOT5" EXACT []

[Term]
id: sgd:S000001273
name: YIL011W
def: "Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog\, TIR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIR3" EXACT []
synonym: "YIB1" EXACT []

[Term]
id: sgd:S000001274
name: YIL012W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001275
name: YIL013C
def: "ATP-binding cassette \(ABC\) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog\, AUS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR11" EXACT []
synonym: "PDR11" EXACT []

[Term]
id: sgd:S000001276
name: YIL014W
def: "Alpha-1\,3-mannosyltransferase; adds the fourth and fifth alpha-1\,3-linked mannose residues to O-linked glycans during protein O-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNT3" EXACT []

[Term]
id: sgd:S000001277
name: YIL015W
def: "Aspartyl protease; secreted into the periplasmic space of mating type a cell; helps cells find mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAR1" EXACT []
synonym: "SST1" EXACT []
synonym: "aspartyl protease BAR1" EXACT []

[Term]
id: sgd:S000001278
name: YIL016W
def: "Ribosome-associated protein; proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNL1" EXACT []

[Term]
id: sgd:S000001279
name: YIL017C
def: "GID Complex subunit\, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1\,6-bisphosphatase \(FBPase\); localized to the nucleus and the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID5" EXACT []
synonym: "VID28" EXACT []
synonym: "YIL017W" EXACT []
synonym: "glucose-induced degradation complex subunit VID28" EXACT []

[Term]
id: sgd:S000001280
name: YIL018W
def: "Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog\, RPL2A\, that arose from the whole genome duplication; expression is upregulated at low temperatures" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L2" EXACT []
synonym: "L2B" EXACT []
synonym: "L5B" EXACT []
synonym: "LOT2" EXACT []
synonym: "RPL2B" EXACT []
synonym: "RPL5A" EXACT []
synonym: "YL6" EXACT []
synonym: "ribosomal 60S subunit protein L2B" EXACT []
synonym: "rp8" EXACT []

[Term]
id: sgd:S000001281
name: YIL019W
def: "Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAF1" EXACT []

[Term]
id: sgd:S000001282
name: YIL020C
def: "Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu\, Co\, and Ni salts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6" EXACT []
synonym: "HIS6" EXACT []

[Term]
id: sgd:S000001283
name: YIL021W
def: "RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B44" EXACT []
synonym: "DNA-directed RNA polymerase II core subunit RPB3" EXACT []
synonym: "RPB3" EXACT []

[Term]
id: sgd:S000001284
name: YIL022W
def: "Essential component of the TIM23 complex; tethers the import motor and regulatory factors \(PAM complex\) to the translocation channel \(Tim23p-Tim17p core complex\); TIM23 complex is short for the translocase of the inner mitochondrial membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISP45" EXACT []
synonym: "MIM44" EXACT []
synonym: "MPI1" EXACT []
synonym: "TIM44" EXACT []

[Term]
id: sgd:S000001285
name: YIL023C
def: "Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white\, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP \(ZRT\, IRT-like Protein\) family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YKE4" EXACT []
synonym: "Zn(2+) transporter YKE4" EXACT []

[Term]
id: sgd:S000001286
name: YIL024C
def: "Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001287
name: YIL025C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001288
name: YIL026C
def: "Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRR1" EXACT []
synonym: "SCC3" EXACT []

[Term]
id: sgd:S000001289
name: YIL027C
def: "Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response\, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5\, fly CG15168\, human MMGT" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMC5" EXACT []
synonym: "KRE27" EXACT []

[Term]
id: sgd:S000001290
name: YIL028W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001291
name: YIL029C
def: "Putative protein of unknown function; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\); YIL029C has a paralog\, YPR071W\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001292
name: YIL030C
def: "Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA10" EXACT []
synonym: "E3 ubiquitin-protein ligase SSM4" EXACT []
synonym: "KIS3" EXACT []
synonym: "SSM4" EXACT []

[Term]
id: sgd:S000001293
name: YIL031W
def: "Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMT4" EXACT []
synonym: "ULP2" EXACT []

[Term]
id: sgd:S000001294
name: YIL032C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001295
name: YIL033C
def: "Regulatory subunit of the cyclic AMP-dependent protein kinase \(PKA\); PKA is a component of a signaling pathway that controls a variety of cellular processes\, including metabolism\, cell cycle\, stress response\, stationary phase\, and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCY1" EXACT []
synonym: "SRA1" EXACT []
synonym: "cAMP-dependent protein kinase regulatory subunit BCY1" EXACT []

[Term]
id: sgd:S000001296
name: YIL034C
def: "Beta subunit of the capping protein heterodimer \(Cap1p and Cap2p\); capping protein \(CP\) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAP2" EXACT []
synonym: "F-actin-capping protein subunit beta" EXACT []

[Term]
id: sgd:S000001297
name: YIL035C
def: "Alpha catalytic subunit of casein kinase 2 \(CK2\); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2\, comprised of CKA1\, CKA2\, CKB1 and CKB2\, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKA1" EXACT []
synonym: "casein kinase 2 catalytic subunit CKA1" EXACT []

[Term]
id: sgd:S000001298
name: YIL036W
def: "Basic leucine zipper \(bZIP\) transcription factor\, in ATF/CREB family; mediates transcriptional activation of NCE103 \(encoding carbonic anhydrase\) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog\, ACA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACA2" EXACT []
synonym: "CST6" EXACT []
synonym: "SHF1" EXACT []

[Term]
id: sgd:S000001299
name: YIL037C
def: "Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM2" EXACT []
synonym: "pheromone-regulated protein PRM2" EXACT []

[Term]
id: sgd:S000001300
name: YIL038C
def: "Subunit of CCR4-NOT global transcriptional regulator; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4-NOT core subunit NOT3" EXACT []
synonym: "NOT3" EXACT []

[Term]
id: sgd:S000001301
name: YIL039W
def: "Conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TED1" EXACT []

[Term]
id: sgd:S000001302
name: YIL040W
def: "Protein required for nuclear envelope morphology; nuclear pore complex localization\, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APQ12" EXACT []

[Term]
id: sgd:S000001303
name: YIL041W
def: "BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations\, fluid-phase endocytosis\, polarization of the actin cytoskeleton\, and vacuole biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GVP36" EXACT []

[Term]
id: sgd:S000001304
name: YIL042C
def: "Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKP1" EXACT []
synonym: "protein kinase PKP1" EXACT []

[Term]
id: sgd:S000001305
name: YIL043C
def: "Microsomal cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBR1" EXACT []
synonym: "CBR5" EXACT []

[Term]
id: sgd:S000001306
name: YIL044C
def: "ADP-ribosylation factor \(ARF\) GTPase activating protein \(GAP\) effector; involved in Trans-Golgi-Network \(TGN\) transport; contains C2C2H2 cysteine/histidine motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGE2" EXACT []
synonym: "SAT2" EXACT []

[Term]
id: sgd:S000001307
name: YIL045W
def: "Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog\, GIP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIG2" EXACT []
synonym: "putative protein phosphatase regulator PIG2" EXACT []

[Term]
id: sgd:S000001308
name: YIL046W
def: "F-box protein containing five copies of the WD40 motif; controls cell cycle function\, sulfur metabolism\, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p\, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET30" EXACT []
synonym: "ZRG11" EXACT []

[Term]
id: sgd:S000001309
name: YIL047C
def: "Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYG1" EXACT []

[Term]
id: sgd:S000001310
name: YIL048W
def: "Putative aminophospholipid translocase \(flippase\); involved in endocytosis\, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEO1" EXACT []
synonym: "putative aminophospholipid-translocating P4-type ATPase NEO1" EXACT []

[Term]
id: sgd:S000001311
name: YIL049W
def: "Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol\, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG \(Congenital Disorders of Glycosylation\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFG10" EXACT []

[Term]
id: sgd:S000001312
name: YIL050W
def: "Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism\, expression is cell-cycle regulated; PCL7 has a paralog\, PCL6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL7" EXACT []

[Term]
id: sgd:S000001313
name: YIL051C
def: "Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog\, HMF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IBM1" EXACT []
synonym: "MMF1" EXACT []

[Term]
id: sgd:S000001314
name: YIL052C
def: "Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34\, no bacterial homolog; RPL34B has a paralog\, RPL34A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L34B" EXACT []
synonym: "L34e" EXACT []
synonym: "RPL34B" EXACT []
synonym: "ribosomal 60S subunit protein L34B" EXACT []

[Term]
id: sgd:S000001315
name: YIL053W
def: "Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis\, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog\, GPP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPP1" EXACT []
synonym: "RHR2" EXACT []
synonym: "glycerol-1-phosphatase RHR2" EXACT []

[Term]
id: sgd:S000001316
name: YIL054W
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001317
name: YIL055C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001318
name: YIL056W
def: "Transcriptional activator; required for the vitamin H-responsive element \(VHRE\) mediated induction of VHT1 \(Vitamin H transporter\) and BIO5 \(biotin biosynthesis intermediate transporter\) in response to low biotin concentrations; VHR1 has a paralog\, VHR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHR1" EXACT []

[Term]
id: sgd:S000001319
name: YIL057C
def: "Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog\, RGI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGI2" EXACT []

[Term]
id: sgd:S000001320
name: YIL058W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001321
name: YIL059C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001322
name: YIL060W
def: "Mitochondrial protein of unknown function; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001323
name: YIL061C
def: "Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly\(A\) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNP1" EXACT []
synonym: "U1-70K" EXACT []

[Term]
id: sgd:S000001324
name: YIL062C
def: "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC15" EXACT []

[Term]
id: sgd:S000001325
name: YIL063C
def: "Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p\, GTP-Gsp1p\, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YRB2" EXACT []

[Term]
id: sgd:S000001326
name: YIL064W
def: "Lysine methyltransferase; involved in the dimethylation of eEF1A \(Tef1p/Tef2p\) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFM4" EXACT []
synonym: "SEE1" EXACT []

[Term]
id: sgd:S000001327
name: YIL065C
def: "Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIS1" EXACT []
synonym: "MDV2" EXACT []

[Term]
id: sgd:S000001328
name: YIL066C
def: "Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis\, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog\, RNR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIN1" EXACT []
synonym: "RIR3" EXACT []
synonym: "RNR3" EXACT []
synonym: "ribonucleotide-diphosphate reductase subunit RNR3" EXACT []

[Term]
id: sgd:S000001329
name: YIL067C
def: "Uncharacterized protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001330
name: YIL068C
def: "Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC6" EXACT []

[Term]
id: sgd:S000001331
name: YIL069C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S24\, no bacterial homolog; RPS24B has a paralog\, RPS24A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS24B" EXACT []
synonym: "RPS24EB" EXACT []
synonym: "S24B" EXACT []
synonym: "S24e" EXACT []
synonym: "ribosomal 40S subunit protein S24B" EXACT []

[Term]
id: sgd:S000001332
name: YIL070C
def: "Acidic protein of the mitochondrial matrix; involved in oxidative phosphorylation; related to the human complement receptor gC1q-R" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAM33" EXACT []

[Term]
id: sgd:S000001333
name: YIL071C
def: "Possible shared subunit of Cop9 signalosome \(CSN\) and eIF3; binds eIF3b subunit Prt1p\, has possible dual functions in transcriptional and translational control\, contains a PCI \(Proteasome-COP9 signalosome \(CSN\)-eIF3\) domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSN11" EXACT []
synonym: "PCI8" EXACT []
synonym: "YIH1" EXACT []
synonym: "YIL071W" EXACT []

[Term]
id: sgd:S000001334
name: YIL072W
def: "Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro\, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOP1" EXACT []

[Term]
id: sgd:S000001335
name: YIL073C
def: "Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO22" EXACT []
synonym: "ZIP4" EXACT []

[Term]
id: sgd:S000001336
name: YIL074C
def: "3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog\, SER3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SER33" EXACT []
synonym: "phosphoglycerate dehydrogenase SER33" EXACT []

[Term]
id: sgd:S000001337
name: YIL075C
def: "Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN2" EXACT []
synonym: "SEN3" EXACT []
synonym: "proteasome regulatory particle base subunit RPN2" EXACT []

[Term]
id: sgd:S000001338
name: YIL076W
def: "Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p\, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANU2" EXACT []
synonym: "SEC28" EXACT []

[Term]
id: sgd:S000001339
name: YIL077C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001340
name: YIL078W
def: "Threonyl-tRNA synthetase; essential cytoplasmic protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THS1" EXACT []
synonym: "threonine--tRNA ligase THS1" EXACT []

[Term]
id: sgd:S000001341
name: YIL079C
def: "Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly\(A\) polymerase activity of Pap2p in vitro; AIR1 has a paralog\, AIR2\, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits\, they have nonredundant roles in regulation of substrate specificity of the exosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIR1" EXACT []

[Term]
id: sgd:S000001344
name: YIL082W
def: "Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles \(VLPs\); similar to retroviral Gag" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001345
name: YIL083C
def: "Subunit of the CoA-Synthesizing Protein Complex \(CoA-SPC\); subunits of this complex are\: Cab2p\, Cab3p\, Cab4p\, Cab5p\, Sis2p and Vhs3p; probable phosphopantothenoylcysteine synthetase \(PPCS\)\, which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC \(encoding a bifunctional enzyme with PPCS activity\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAB2" EXACT []
synonym: "phosphopantothenate--cysteine ligase CAB2" EXACT []

[Term]
id: sgd:S000001346
name: YIL084C
def: "Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity\, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDS3" EXACT []

[Term]
id: sgd:S000001347
name: YIL085C
def: "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog\, KTR5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR7" EXACT []

[Term]
id: sgd:S000001348
name: YIL086C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001349
name: YIL087C
def: "Putative protein of unknown function; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM19" EXACT []
synonym: "LRC2" EXACT []

[Term]
id: sgd:S000001350
name: YIL088C
def: "Putative transporter; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT7" EXACT []

[Term]
id: sgd:S000001351
name: YIL089W
def: "Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001352
name: YIL090W
def: "Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICE2" EXACT []

[Term]
id: sgd:S000001353
name: YIL091C
def: "Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP25" EXACT []

[Term]
id: sgd:S000001354
name: YIL092W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001355
name: YIL093C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM25" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM25" EXACT []

[Term]
id: sgd:S000001356
name: YIL094C
def: "Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine\, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS10" EXACT []
synonym: "LYS11" EXACT []
synonym: "LYS12" EXACT []
synonym: "homoisocitrate dehydrogenase" EXACT []

[Term]
id: sgd:S000001357
name: YIL095W
def: "Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog\, ARK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAK1" EXACT []
synonym: "PRK1" EXACT []
synonym: "serine/threonine protein kinase PRK1" EXACT []

[Term]
id: sgd:S000001358
name: YIL096C
def: "Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BMT5" EXACT []

[Term]
id: sgd:S000001359
name: YIL097W
def: "Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase\, PEPCK\, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo\, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV10" EXACT []
synonym: "GID9" EXACT []
synonym: "glucose-induced degradation complex subunit FYV10" EXACT []

[Term]
id: sgd:S000001360
name: YIL098C
def: "Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMC1" EXACT []

[Term]
id: sgd:S000001361
name: YIL099W
def: "Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation\, but dispensable for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4-alpha-glucosidase" EXACT []
synonym: "SGA1" EXACT []
synonym: "glucan 1" EXACT []

[Term]
id: sgd:S000001362
name: YIL100W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001363
name: YIL101C
def: "Transcriptional repressor; binds to promoter sequences of the cyclin genes\, CYS3\, and SMF2; expression is induced by stress or starvation during mitosis\, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "XBP1" EXACT []

[Term]
id: sgd:S000001364
name: YIL102C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001365
name: YIL103W
def: "Protein required for synthesis of diphthamide; required along with Dph2p\, Kti11p\, Jjj3p\, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 \(Eft1p or Eft2p\); may act in a complex with Dph2p and Kti11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH1" EXACT []
synonym: "KIF48" EXACT []

[Term]
id: sgd:S000001366
name: YIL104C
def: "Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHQ1" EXACT []

[Term]
id: sgd:S000001367
name: YIL105C
def: "Phosphoinositide PI4\,5P\(2\) binding protein\, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog\, SLM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIT2" EXACT []
synonym: "SLM1" EXACT []

[Term]
id: sgd:S000001368
name: YIL106W
def: "Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOB1" EXACT []

[Term]
id: sgd:S000001369
name: YIL107C
def: "6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2\,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFK-2" EXACT []
synonym: "PFK2" EXACT []
synonym: "PFK26" EXACT []

[Term]
id: sgd:S000001370
name: YIL108W
def: "Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative metalloendopeptidase" EXACT []

[Term]
id: sgd:S000001371
name: YIL109C
def: "Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog\, SFB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANU1" EXACT []
synonym: "COPII subunit SEC24" EXACT []
synonym: "SEC24" EXACT []

[Term]
id: sgd:S000001372
name: YIL110W
def: "AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPM1" EXACT []
synonym: "MNI1" EXACT []

[Term]
id: sgd:S000001373
name: YIL111W
def: "Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va \(Cox5Ap\) is expressed during aerobic growth; COX5B has a paralog\, COX5A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX5B" EXACT []
synonym: "cytochrome c oxidase subunit Vb" EXACT []

[Term]
id: sgd:S000001374
name: YIL112W
def: "Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOS4" EXACT []

[Term]
id: sgd:S000001375
name: YIL113W
def: "Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation\, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog\, MSG5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDP1" EXACT []
synonym: "mitogen-activated protein kinase tyrosine protein phosphatase SDP1" EXACT []

[Term]
id: sgd:S000001376
name: YIL114C
def: "Putative mitochondrial porin \(voltage-dependent anion channel\); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog\, POR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POR2" EXACT []
synonym: "YVDAC2" EXACT []
synonym: "putative porin POR2" EXACT []

[Term]
id: sgd:S000001377
name: YIL115C
def: "FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex \(NPC\) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p\, Gle2p and two other FG-nucleoporins \(Nsp1p and Nup116p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP159" EXACT []
synonym: "NUP158" EXACT []
synonym: "NUP159" EXACT []
synonym: "RAT7" EXACT []

[Term]
id: sgd:S000001378
name: YIL116W
def: "Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu\, Co\, and Ni salts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIS5" EXACT []
synonym: "histidinol-phosphate transaminase" EXACT []

[Term]
id: sgd:S000001379
name: YIL117C
def: "Pheromone-regulated protein\, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog\, YNL058C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM5" EXACT []
synonym: "pheromone-regulated protein PRM5" EXACT []

[Term]
id: sgd:S000001380
name: YIL118W
def: "Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein \(GAP\) Rgd1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHO3" EXACT []
synonym: "Rho family GTPase RHO3" EXACT []

[Term]
id: sgd:S000001381
name: YIL119C
def: "Transcription factor\, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPI1" EXACT []

[Term]
id: sgd:S000001382
name: YIL120W
def: "Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3\, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine\, ketoconazole\, fluconazole\, and barban; QDR1 has a paralog\, AQR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QDR1" EXACT []

[Term]
id: sgd:S000001383
name: YIL121W
def: "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine\, barban\, cisplatin\, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QDR2" EXACT []

[Term]
id: sgd:S000001384
name: YIL122W
def: "Nuclear chromatin-associated protein of unknown function; may have a role in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phsosphoylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; SBF regulated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POG1" EXACT []

[Term]
id: sgd:S000001385
name: YIL123W
def: "Protein of the SUN family \(Sim1p\, Uth1p\, Nca3p\, Sun4p\); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog\, SUN4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIM1" EXACT []
synonym: "putative glucosidase SIM1" EXACT []

[Term]
id: sgd:S000001386
name: YIL124W
def: "Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles\, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AYR1" EXACT []
synonym: "GBG1" EXACT []
synonym: "acylglycerone-phosphate reductase" EXACT []

[Term]
id: sgd:S000001387
name: YIL125W
def: "Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid \(TCA\) cycle\, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KGD1" EXACT []
synonym: "OGD1" EXACT []
synonym: "alpha-ketoglutarate dehydrogenase KGD1" EXACT []

[Term]
id: sgd:S000001388
name: YIL126W
def: "ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPS1" EXACT []
synonym: "RSC chromatin remodeling complex ATPase subunit STH1" EXACT []
synonym: "STH1" EXACT []

[Term]
id: sgd:S000001389
name: YIL127C
def: "Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT14" EXACT []

[Term]
id: sgd:S000001390
name: YIL128W
def: "Component of cytosolic iron-sulfur protein assembly \(CIA\) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis\, DNA replication and repair\, transcription\, and telomere maintenance; ortholog of human MMS19" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET18" EXACT []
synonym: "MMS19" EXACT []

[Term]
id: sgd:S000001391
name: YIL129C
def: "Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis\, interacts with protein kinase Cbk1p and also with Kic1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAG1" EXACT []
synonym: "TAO3" EXACT []

[Term]
id: sgd:S000001392
name: YIL130W
def: "Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency\, calcofluor white sensitivity and slightly increased cycloheximide resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASG1" EXACT []

[Term]
id: sgd:S000001393
name: YIL131C
def: "Forkhead family transcription factor; minor role in expression of G2/M phase genes; negatively regulates transcription elongation; positive role in chromatin silencing at HML\, HMR; facilitates clustering and activation of early-firing replication origins; binds to recombination enhancer near HML\, regulates donor preference during mating-type switching; relocalizes to cytosol in response to hypoxia; FKH1 has a paralog\, FKH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FKH1" EXACT []
synonym: "forkhead family transcription factor FKH1" EXACT []

[Term]
id: sgd:S000001394
name: YIL132C
def: "Component of Shu complex \(aka PCSS complex\); Shu complex also includes Psy3\, Shu1\, Shu2\, and promotes error-free DNA repair\,; Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSM2" EXACT []

[Term]
id: sgd:S000001395
name: YIL133C
def: "Ribosomal 60S subunit protein L16A; N-terminally acetylated\, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog\, RPL16B\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13" EXACT []
synonym: "L16A" EXACT []
synonym: "L21A" EXACT []
synonym: "RPL13" EXACT []
synonym: "RPL16A" EXACT []
synonym: "YL15" EXACT []
synonym: "ribosomal 60S subunit protein L16A" EXACT []
synonym: "rp22" EXACT []

[Term]
id: sgd:S000001396
name: YIL134W
def: "Protein required for transport of flavin adenine dinucleotide \(FAD\); a synthesis product of riboflavin\, across the mitochondrial membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLX1" EXACT []

[Term]
id: sgd:S000001397
name: YIL135C
def: "Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry\, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog\, MLF3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHS2" EXACT []

[Term]
id: sgd:S000001398
name: YIL136W
def: "Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane\, located on the outer \(cytosolic\) face; interacts with porin \(Por1p\) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes\, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OM45" EXACT []

[Term]
id: sgd:S000001399
name: YIL137C
def: "Ribosome-associated protein that is involved in ribosome biogenesis; putative metalloprotease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF108" EXACT []
synonym: "TAE3" EXACT []
synonym: "TMA108" EXACT []

[Term]
id: sgd:S000001400
name: YIL138C
def: "Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments\, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog\, TPM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPM2" EXACT []
synonym: "tropomyosin TPM2" EXACT []

[Term]
id: sgd:S000001401
name: YIL139C
def: "Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev3p\, Pol31p and Pol32p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REV7" EXACT []

[Term]
id: sgd:S000001402
name: YIL140W
def: "Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AXL2" EXACT []
synonym: "BUD10" EXACT []
synonym: "SRO4" EXACT []

[Term]
id: sgd:S000001403
name: YIL141W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001404
name: YIL142W
def: "Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIN3" EXACT []
synonym: "CCT2" EXACT []
synonym: "TCP2" EXACT []

[Term]
id: sgd:S000001405
name: YIL143C
def: "Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required\, with Rad3p\, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to the cytosol in response to hypoxia; homolog of human ERCC3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOM3" EXACT []
synonym: "RAD25" EXACT []
synonym: "SSL2" EXACT []
synonym: "TFIIH/NER complex ATPase/helicase subunit SSL2" EXACT []

[Term]
id: sgd:S000001406
name: YIL144W
def: "Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation\, spindle checkpoint activity\, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p\, Nuf2p\, Scp24p\, and Spc25p; modified by sumoylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEC1" EXACT []
synonym: "NDC80" EXACT []
synonym: "TID3" EXACT []

[Term]
id: sgd:S000001407
name: YIL145C
def: "Pantothenate synthase; also known as pantoate-beta-alanine ligase\, required for pantothenic acid biosynthesis\, deletion causes pantothenic acid auxotrophy\, homologous to E. coli panC" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAN6" EXACT []
synonym: "pantoate--beta-alanine ligase PAN6" EXACT []

[Term]
id: sgd:S000001408
name: YIL146C
def: "Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy\, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG32" EXACT []
synonym: "ECM37" EXACT []
synonym: "mitophagy protein ATG32" EXACT []

[Term]
id: sgd:S000001409
name: YIL147C
def: "Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p\, thereby forming a phosphorelay system similar to bacterial two-component regulators" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLN1" EXACT []
synonym: "YPD2" EXACT []

[Term]
id: sgd:S000001410
name: YIL148W
def: "Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40\, no bacterial homolog; RPL40A has a paralog\, RPL40B\, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEP52A" EXACT []
synonym: "L40A" EXACT []
synonym: "L40e" EXACT []
synonym: "RPL40A" EXACT []
synonym: "UB11" EXACT []
synonym: "UBI1" EXACT []
synonym: "ubiquitin-ribosomal 60S subunit protein L40A fusion protein" EXACT []

[Term]
id: sgd:S000001411
name: YIL149C
def: "Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog\, MLP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLP2" EXACT []

[Term]
id: sgd:S000001412
name: YIL150C
def: "Essential chromatin-associated protein; involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA43" EXACT []
synonym: "MCM10" EXACT []

[Term]
id: sgd:S000001413
name: YIL151C
def: "Protein of unknown function; predicted to contain a PINc domain; ESL1 has a paralog\, ESL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESL1" EXACT []

[Term]
id: sgd:S000001414
name: YIL152W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001415
name: YIL153W
def: "Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression\, microtubule dynamics\, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRD1" EXACT []
synonym: "YPA1" EXACT []
synonym: "peptidylprolyl isomerase RRD1" EXACT []

[Term]
id: sgd:S000001416
name: YIL154C
def: "Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP2" EXACT []
synonym: "IMP2'" EXACT []

[Term]
id: sgd:S000001417
name: YIL155C
def: "Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p\, Rsf1p\, Hap2/3/4/5 complex dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUT2" EXACT []
synonym: "glycerol-3-phosphate dehydrogenase" EXACT []

[Term]
id: sgd:S000001418
name: YIL156W
def: "Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog\, UBP11\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP7" EXACT []

[Term]
id: sgd:S000001419
name: YIL157C
def: "Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex \(complex IV\); interacts with complex IV assembly factor Shy1p during the early stages of assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COA1" EXACT []
synonym: "FMP35" EXACT []

[Term]
id: sgd:S000001420
name: YIL158W
def: "Putative protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein \(GFP\)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog\, SKG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM20" EXACT []

[Term]
id: sgd:S000001421
name: YIL159W
def: "Formin; nucleates the formation of linear actin filaments\, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables\, functionally redundant with BNI1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNR1" EXACT []
synonym: "formin BNR1" EXACT []

[Term]
id: sgd:S000001422
name: YIL160C
def: "3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOX3" EXACT []
synonym: "POT1" EXACT []
synonym: "POX3" EXACT []
synonym: "acetyl-CoA C-acyltransferase" EXACT []

[Term]
id: sgd:S000001423
name: YIL161W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001424
name: YIL162W
def: "Invertase; sucrose hydrolyzing enzyme; a secreted\, glycosylated form is regulated by glucose repression\, and an intracellular\, nonglycosylated enzyme is produced constitutively" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUC2" EXACT []
synonym: "beta-fructofuranosidase SUC2" EXACT []

[Term]
id: sgd:S000001425
name: YIL163C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001426
name: YIL164C
def: "Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF\, YIL165C\, likely constitute a single ORF encoding a nitrilase gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIT1" EXACT []

[Term]
id: sgd:S000001427
name: YIL165C
def: "Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF\, YIL164C\, likely constitute a single ORF encoding a nitrilase gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001428
name: YIL166C
def: "Putative protein with similarity to allantoate permease; similar to the allantoate permease \(Dal5p\) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001431
name: YIL169C
def: "Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C\, a putative glucan alpha-1\,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPF1'" EXACT []

[Term]
id: sgd:S000001434
name: YIL172C
def: "Alpha-glucosidase; weak\, but broad substrate specificity for alpha-1\,4- and alpha-1\,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization\, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1\,3 linkage of nigerose and turanose\, but not alpha-1\,5 of leucrose; identical to IMA4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase IMA3" EXACT []
synonym: "IMA3" EXACT []
synonym: "oligo-1" EXACT []

[Term]
id: sgd:S000001435
name: YIL173W
def: "Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VTH1" EXACT []

[Term]
id: sgd:S000001438
name: YIL176C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU14" EXACT []
synonym: "seripauperin PAU14" EXACT []

[Term]
id: sgd:S000001439
name: YIL177C
def: "Putative Y' element ATP-dependent helicase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000001440
name: YIR001C
def: "Cytoplasmic RNA-binding protein; contains an RNA recognition motif \(RRM\); may have a role in mRNA translation\, as suggested by genetic interactions with genes encoding proteins involved in translational initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBP1" EXACT []
synonym: "RBP29" EXACT []
synonym: "SGN1" EXACT []

[Term]
id: sgd:S000001441
name: YIR002C
def: "3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA in error-free bypass pathway\, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; similar to FANCM human Fanconi anemia complementation group protein that with MHF complex is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPH1" EXACT []

[Term]
id: sgd:S000001442
name: YIR003W
def: "Protein of unknown function; involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM21" EXACT []

[Term]
id: sgd:S000001443
name: YIR004W
def: "Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly\, homologous to E. coli DnaJ" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DJP1" EXACT []
synonym: "ICS1" EXACT []
synonym: "PAS22" EXACT []

[Term]
id: sgd:S000001444
name: YIR005W
def: "Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IST3" EXACT []
synonym: "SNU17" EXACT []

[Term]
id: sgd:S000001445
name: YIR006C
def: "Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress; previously thought to be a subunit of poly\(A\) ribonuclease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIM2" EXACT []
synonym: "MDP3" EXACT []
synonym: "MIP3" EXACT []
synonym: "PAN1" EXACT []

[Term]
id: sgd:S000001446
name: YIR007W
def: "Putative glycosidase; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "hydrolase" EXACT []

[Term]
id: sgd:S000001447
name: YIR008C
def: "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA primase subunit PRI1" EXACT []
synonym: "PRI1" EXACT []

[Term]
id: sgd:S000001448
name: YIR009W
def: "U2B component of U2 snRNP; involved in splicing\, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSL1" EXACT []
synonym: "YIB9" EXACT []
synonym: "YIB9w" EXACT []

[Term]
id: sgd:S000001449
name: YIR010W
def: "Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation of Dsn1p promotes interaction between outer and inner kinetochore proteins; N-terminal end interacts with monopolin subunit Csm1p and is essential for meiotic but not mitotic chromosome segregation; important for chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p \(MIND\); modified by sumoylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSN1" EXACT []
synonym: "MIND complex subunit DSN1" EXACT []

[Term]
id: sgd:S000001450
name: YIR011C
def: "Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBF8" EXACT []
synonym: "SSM5" EXACT []
synonym: "STS1" EXACT []

[Term]
id: sgd:S000001451
name: YIR012W
def: "Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SQT1" EXACT []

[Term]
id: sgd:S000001452
name: YIR013C
def: "Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3\, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT4" EXACT []

[Term]
id: sgd:S000001453
name: YIR014W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001454
name: YIR015W
def: "Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P\, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPR2" EXACT []

[Term]
id: sgd:S000001455
name: YIR016W
def: "Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog\, YOL036W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001456
name: YIR017C
def: "bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET28" EXACT []

[Term]
id: sgd:S000001457
name: YIR018W
def: "Basic leucine zipper \(bZIP\) iron-sensing transcription factor; involved in diauxic shift; YAP5 has a paralog\, YAP7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP5" EXACT []

[Term]
id: sgd:S000001458
name: YIR019C
def: "GPI-anchored cell surface glycoprotein \(flocculin\); required for pseudohyphal formation\, invasive growth\, flocculation\, and biofilms; transcriptionally regulated by the MAPK pathway \(via Ste12p and Tec1p\) and the cAMP pathway \(via Flo8p\); required for formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain; a portion is cleaved and shed from cells\, and free extracellular Flo11p contributes to the surface properties of cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLO11" EXACT []
synonym: "MUC1" EXACT []
synonym: "STA4" EXACT []

[Term]
id: sgd:S000001459
name: YIR020C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001460
name: YIR021W
def: "Splicing protein; required for splicing of two mitochondrial group I introns \(BI3 in COB and AI5beta in COX1\); forms a splicing complex\, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase\, that binds to the BI3 RNA; MRS1 has a paralog\, CCE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS1" EXACT []
synonym: "PET157" EXACT []

[Term]
id: sgd:S000001461
name: YIR022W
def: "18kDa catalytic subunit of the Signal Peptidase Complex \(SPC\); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p\, Spc2p\, Spc3p\, and Sec11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC11" EXACT []

[Term]
id: sgd:S000001462
name: YIR023W
def: "Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL81" EXACT []
synonym: "DURL" EXACT []
synonym: "UGA35" EXACT []

[Term]
id: sgd:S000001463
name: YIR024C
def: "F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex \(Ina22p-Ina17p\) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p\, ATP synthase subunits\, and cytochrome bc1 complex assembly factors; interacts with Arh1p\, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIF1" EXACT []
synonym: "INA22" EXACT []

[Term]
id: sgd:S000001464
name: YIR025W
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC\(Ama1\) ubiquitin ligase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MND2" EXACT []

[Term]
id: sgd:S000001465
name: YIR026C
def: "Protein phosphatase; involved in vegetative growth at low temperatures\, sporulation\, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YVH1" EXACT []
synonym: "tyrosine protein phosphatase YVH1" EXACT []

[Term]
id: sgd:S000001466
name: YIR027C
def: "Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL1" EXACT []
synonym: "allantoinase" EXACT []

[Term]
id: sgd:S000001467
name: YIR028W
def: "Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate\, an intermediate in allantoin degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL4" EXACT []

[Term]
id: sgd:S000001468
name: YIR029W
def: "Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate\, an intermediate in allantoin degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALC1" EXACT []
synonym: "DAL2" EXACT []
synonym: "allantoicase" EXACT []

[Term]
id: sgd:S000001469
name: YIR030C
def: "Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCG1" EXACT []

[Term]
id: sgd:S000001470
name: YIR031C
def: "Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate\, an intermediate in allantoin degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL7" EXACT []
synonym: "MLS2" EXACT []
synonym: "MSL2" EXACT []
synonym: "malate synthase DAL7" EXACT []

[Term]
id: sgd:S000001471
name: YIR032C
def: "Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to \"ureidoglycolate hydrolase\" but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate\, ammonia and carbon dioxide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL3" EXACT []
synonym: "ureidoglycolate hydrolase" EXACT []

[Term]
id: sgd:S000001472
name: YIR033W
def: "ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog\, SPT23\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGA2" EXACT []

[Term]
id: sgd:S000001473
name: YIR034C
def: "Saccharopine dehydrogenase \(NAD+\, L-lysine-forming\); catalyzes the conversion of saccharopine to L-lysine\, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: " L-lysine-forming)" EXACT []
synonym: "LYS1" EXACT []
synonym: "saccharopine dehydrogenase (NAD+" EXACT []

[Term]
id: sgd:S000001474
name: YIR035C
def: "Putative cytoplasmic short-chain dehydrogenase/reductase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "sepiapterin reductase family protein" EXACT []

[Term]
id: sgd:S000001475
name: YIR036C
def: "Putative benzil reductase;\(GFP\)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC24" EXACT []
synonym: "sepiapterin reductase family protein IRC24" EXACT []

[Term]
id: sgd:S000001476
name: YIR037W
def: "Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; HYR1 has a paralog\, GPX1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPX3" EXACT []
synonym: "HYR1" EXACT []
synonym: "ORP1" EXACT []
synonym: "peroxiredoxin HYR1" EXACT []

[Term]
id: sgd:S000001477
name: YIR038C
def: "ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p\, Grx1p\, and Grx2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTT1" EXACT []
synonym: "bifunctional glutathione transferase/peroxidase" EXACT []

[Term]
id: sgd:S000001478
name: YIR039C
def: "Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPS6" EXACT []

[Term]
id: sgd:S000001479
name: YIR040C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001480
name: YIR041W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU15" EXACT []
synonym: "seripauperin PAU15" EXACT []

[Term]
id: sgd:S000001481
name: YIR042C
def: "Putative protein of unknown function; YIR042C is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001484
name: YKL001C
def: "Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET14" EXACT []
synonym: "adenylyl-sulfate kinase" EXACT []

[Term]
id: sgd:S000001485
name: YKL002W
def: "Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies\, and for delivery of newly synthesized vacuolar enzymes to the vacuole\, involved in endocytosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHM2" EXACT []
synonym: "DID4" EXACT []
synonym: "ESCRT-III subunit protein DID4" EXACT []
synonym: "GRD7" EXACT []
synonym: "REN1" EXACT []
synonym: "VPL2" EXACT []
synonym: "VPS14" EXACT []
synonym: "VPS2" EXACT []
synonym: "VPT14" EXACT []

[Term]
id: sgd:S000001486
name: YKL003C
def: "Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122\, encoding a COX3-specific translational activator" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP17" EXACT []
synonym: "mitochondrial 37S ribosomal protein YmS16" EXACT []

[Term]
id: sgd:S000001487
name: YKL004W
def: "Phosphatidylinositol\:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AUR1" EXACT []
synonym: "inositol phosphorylceramide synthase" EXACT []

[Term]
id: sgd:S000001488
name: YKL005C
def: "Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations\, binds RNA polymerase II large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BYE1" EXACT []

[Term]
id: sgd:S000001489
name: YKL006W
def: "Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14\, no bacterial homolog; RPL14A has a paralog\, RPL14B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L14A" EXACT []
synonym: "L14e" EXACT []
synonym: "RPL14A" EXACT []
synonym: "ribosomal 60S subunit protein L14A" EXACT []

[Term]
id: sgd:S000001490
name: YKL007W
def: "Alpha subunit of the capping protein heterodimer \(Cap1p and Cap2p\); capping protein \(CP\) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAP1" EXACT []

[Term]
id: sgd:S000001491
name: YKL008C
def: "Ceramide synthase component; involved in synthesis of ceramide from C26\(acyl\)-coenzyme A and dihydrosphingosine or phytosphingosine\, functionally equivalent to Lag1p; LAC1 has a paralog\, LAG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DGT1" EXACT []
synonym: "LAC1" EXACT []
synonym: "sphingosine N-acyltransferase LAC1" EXACT []

[Term]
id: sgd:S000001492
name: YKL009W
def: "Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRT4" EXACT []

[Term]
id: sgd:S000001493
name: YKL010C
def: "Ubiquitin-protein ligase \(E3\); interacts with Rpt4p and Rpt6p\, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UFD4" EXACT []
synonym: "putative ubiquitin-protein ligase UFD4" EXACT []

[Term]
id: sgd:S000001494
name: YKL011C
def: "Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog\, MRS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCE1" EXACT []
synonym: "MGT1" EXACT []

[Term]
id: sgd:S000001495
name: YKL012W
def: "U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP40" EXACT []

[Term]
id: sgd:S000001496
name: YKL013C
def: "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC19" EXACT []

[Term]
id: sgd:S000001497
name: YKL014C
def: "Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPA1" EXACT []
synonym: "URB1" EXACT []

[Term]
id: sgd:S000001498
name: YKL015W
def: "Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes\, constitutively binds PUT1 and PUT2 promoters as a dimer\, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn\(2\)-Cys\(6\) binuclear cluster domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUT3" EXACT []

[Term]
id: sgd:S000001499
name: YKL016C
def: "Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP7" EXACT []
synonym: "F1F0 ATP synthase subunit d" EXACT []

[Term]
id: sgd:S000001500
name: YKL017C
def: "Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent 5'-3' DNA helicase HCS1" EXACT []
synonym: "DIP1" EXACT []
synonym: "HCS1" EXACT []

[Term]
id: sgd:S000001501
name: YKL018W
def: "Subunit of the COMPASS \(Set1C\) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF \(cleavage and polyadenylation factor\)\, a complex involved in RNAP II transcription termination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS35" EXACT []
synonym: "SAF37" EXACT []
synonym: "SWD2" EXACT []

[Term]
id: sgd:S000001502
name: YKL019W
def: "Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase \(RAM2-RAM1 heterodimer\) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase \(RAM2-CDC43 heterodimer\) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAM2" EXACT []
synonym: "bifunctional protein farnesyltransferase/protein geranylgeranyltransferase" EXACT []

[Term]
id: sgd:S000001503
name: YKL020C
def: "ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog\, MGA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPT23" EXACT []

[Term]
id: sgd:S000001504
name: YKL021C
def: "Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK11" EXACT []

[Term]
id: sgd:S000001505
name: YKL022C
def: "Subunit of the anaphase-promoting complex/cyclosome \(APC/C\); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC16" EXACT []
synonym: "anaphase promoting complex subunit CDC16" EXACT []

[Term]
id: sgd:S000001506
name: YKL023W
def: "Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001507
name: YKL024C
def: "Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines\, converting uridine monophosphate \(UMP\) into uridine-5'-diphosphate \(UDP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOC8" EXACT []
synonym: "URA6" EXACT []
synonym: "bifunctional uridylate/adenylate kinase" EXACT []

[Term]
id: sgd:S000001508
name: YKL025C
def: "Essential subunit of the Pan2p-Pan3p poly\(A\)-ribonuclease complex; poly \(A\) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly\(A\) tail length and regulates the stoichiometry and activity of postreplication repair complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM35" EXACT []
synonym: "PAN3" EXACT []

[Term]
id: sgd:S000001509
name: YKL026C
def: "Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog\, HYR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPX1" EXACT []
synonym: "glutathione peroxidase GPX1" EXACT []

[Term]
id: sgd:S000001510
name: YKL027W
def: "tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification\, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog\, TCD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCD2" EXACT []

[Term]
id: sgd:S000001511
name: YKL028W
def: "TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter\, activation of TFIIH\, and promoter opening" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFA1" EXACT []

[Term]
id: sgd:S000001512
name: YKL029C
def: "Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate\, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAE1" EXACT []
synonym: "malate dehydrogenase (oxaloacetate-decarboxylating)" EXACT []

[Term]
id: sgd:S000001513
name: YKL030W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001514
name: YKL031W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001515
name: YKL032C
def: "Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b\, TIR1\, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG \(high mobility group box\) domain containing protein which binds and bends cisplatin-modified DNA\, blocking excision repair; IXR1 has a paralog\, ABF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IXR1" EXACT []
synonym: "ORD1" EXACT []

[Term]
id: sgd:S000001516
name: YKL033W
def: "Subunit of the ASTRA complex\, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP47" EXACT []
synonym: "TTI1" EXACT []

[Term]
id: sgd:S000001517
name: YKL034W
def: "Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase \(E3\) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUL1" EXACT []
synonym: "ubiquitin-protein ligase TUL1" EXACT []

[Term]
id: sgd:S000001518
name: YKL035W
def: "UDP-glucose pyrophosphorylase \(UGPase\); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP\, involved in a wide variety of metabolic pathways\, expression modulated by Pho85p through Pho4p; UGP1 has a paralog\, YHL012W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGP1" EXACT []
synonym: "UTP glucose-1-phosphate uridylyltransferase" EXACT []

[Term]
id: sgd:S000001519
name: YKL036C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001520
name: YKL037W
def: "Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM26" EXACT []

[Term]
id: sgd:S000001521
name: YKL038W
def: "Glucose-responsive transcription factor; regulates expression of several glucose transporter \(HXT\) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog\, EDS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGT1" EXACT []

[Term]
id: sgd:S000001522
name: YKL039W
def: "Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog\, YHL017W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTM1" EXACT []

[Term]
id: sgd:S000001523
name: YKL040C
def: "Protein involved in iron metabolism in mitochondria; similar to NifU\, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NFU1" EXACT []
synonym: "NUB1" EXACT []

[Term]
id: sgd:S000001524
name: YKL041W
def: "One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III \(ESCRT-III\) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body \(MVB\) pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DID3" EXACT []
synonym: "ESCRT-III subunit protein VPS24" EXACT []
synonym: "VPL26" EXACT []
synonym: "VPS24" EXACT []

[Term]
id: sgd:S000001525
name: YKL042W
def: "Central plaque component of spindle pole body \(SPB\); involved in SPB duplication\, may facilitate attachment of the SPB to the nuclear membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC42" EXACT []

[Term]
id: sgd:S000001526
name: YKL043W
def: "Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11\, an adhesin required for pseudohyphal filament formation; similar to StuA\, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog\, SOK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHD1" EXACT []

[Term]
id: sgd:S000001527
name: YKL044W
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001528
name: YKL045W
def: "Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA primase subunit PRI2" EXACT []
synonym: "PRI2" EXACT []

[Term]
id: sgd:S000001529
name: YKL046C
def: "Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCW1" EXACT []

[Term]
id: sgd:S000001530
name: YKL047W
def: "Putative protein of unknown function; may have a role in lipid metabolism\, based on localization to lipid droplets; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANR2" EXACT []

[Term]
id: sgd:S000001531
name: YKL048C
def: "Serine/threonine protein kinase that regulates cellular morphogenesis; septin behavior\, and cytokinesis; required for the regulation of other kinases\, such as Kin4p; forms part of the bud neck ring" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELM1" EXACT []
synonym: "LDB9" EXACT []
synonym: "serine/threonine protein kinase ELM1" EXACT []

[Term]
id: sgd:S000001532
name: YKL049C
def: "Centromere protein that resembles histone H3; associated with promoters\, accessible chromatin and RNA polymerase II-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation of Cse4p may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N terminus regulates Cse4p proteolysis for faithful chromosome segregation; human CENP-A homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSE4" EXACT []
synonym: "CSL2" EXACT []
synonym: "centromeric DNA-binding histone H3-like protein CSE4" EXACT []

[Term]
id: sgd:S000001533
name: YKL050C
def: "Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has a paralog\, EIS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001534
name: YKL051W
def: "Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFK1" EXACT []

[Term]
id: sgd:S000001535
name: YKL052C
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASK1" EXACT []

[Term]
id: sgd:S000001536
name: YKL053W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001537
name: YKL054C
def: "RNAPII degradation factor; forms a complex with Rad26p in chromatin\, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEF1" EXACT []
synonym: "DNA damage-responsive RNA polymerase-degradation factor DEF1" EXACT []
synonym: "VID31" EXACT []

[Term]
id: sgd:S000001538
name: YKL055C
def: "Mitochondrial 3-oxoacyl-\[acyl-carrier-protein\] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)" EXACT []
synonym: "OAR1" EXACT []

[Term]
id: sgd:S000001539
name: YKL056C
def: "Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMI1" EXACT []
synonym: "RBF18" EXACT []
synonym: "TMA19" EXACT []

[Term]
id: sgd:S000001540
name: YKL057C
def: "Subunit of the Nup84p subcomplex of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery\, including double-strand break repair\, transcription and chromatin silencing; homologous to human NUP160" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP120" EXACT []
synonym: "RAT2" EXACT []

[Term]
id: sgd:S000001541
name: YKL058W
def: "TFIIA small subunit; involved in transcriptional activation\, acts as antirepressor or as coactivator; required\, along with Toa1p\, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFIIA subunit gamma" EXACT []
synonym: "TOA2" EXACT []

[Term]
id: sgd:S000001542
name: YKL059C
def: "Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like \(UBL\) domain\, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPE1" EXACT []

[Term]
id: sgd:S000001543
name: YKL060C
def: "Fructose 1\,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1\,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FBA1" EXACT []
synonym: "LOT1" EXACT []
synonym: "fructose-bisphosphate aldolase FBA1" EXACT []

[Term]
id: sgd:S000001544
name: YKL061W
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein \(GFP\)-fusion protein localizes to the endosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLI1" EXACT []

[Term]
id: sgd:S000001545
name: YKL062W
def: "Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes\, inducing gene expression; involved in diauxic shift" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSN4" EXACT []
synonym: "stress-responsive transcriptional activator MSN4" EXACT []

[Term]
id: sgd:S000001546
name: YKL063C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the Golgi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001547
name: YKL064W
def: "Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p\, which mediate influx of Mg2+ and other divalent cations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNR2" EXACT []
synonym: "putative Mg(2+) transporter MNR2" EXACT []

[Term]
id: sgd:S000001548
name: YKL065C
def: "Endoplasmic reticulum transmembrane protein; may interact with ribosomes\, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog\, YET2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YET1" EXACT []

[Term]
id: sgd:S000001549
name: YKL066W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001550
name: YKL067W
def: "Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates\, usually ATP\, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDK1" EXACT []
synonym: "YNK1" EXACT []
synonym: "nucleoside diphosphate kinase" EXACT []

[Term]
id: sgd:S000001551
name: YKL068W
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex \(NPC\) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog\, NUP116\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP100" EXACT []
synonym: "NSP100" EXACT []
synonym: "NUP100" EXACT []
synonym: "[NUP100+]" EXACT []

[Term]
id: sgd:S000001552
name: YKL069W
def: "Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO\, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YKG9" EXACT []
synonym: "fRMsr" EXACT []

[Term]
id: sgd:S000001553
name: YKL070W
def: "Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001554
name: YKL071W
def: "Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin\, and also the quinone methide triterpene celastrol; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001555
name: YKL072W
def: "Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog\, STB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB6" EXACT []

[Term]
id: sgd:S000001556
name: YKL073W
def: "Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CER1" EXACT []
synonym: "Hsp70 family chaperone LHS1" EXACT []
synonym: "LHS1" EXACT []
synonym: "SSI1" EXACT []

[Term]
id: sgd:S000001557
name: YKL074C
def: "Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex\, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUD2" EXACT []

[Term]
id: sgd:S000001558
name: YKL075C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001559
name: YKL076C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSY1" EXACT []

[Term]
id: sgd:S000001560
name: YKL077W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001561
name: YKL078W
def: "Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHR2" EXACT []

[Term]
id: sgd:S000001562
name: YKL079W
def: "Kinesin-like myosin passenger-protein; interacts with Myo2p; controls actin cable structure and dynamics; proposed to be involved in exocytosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMY1" EXACT []

[Term]
id: sgd:S000001563
name: YKL080W
def: "Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase \(V-ATPase\) has eight subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSL5" EXACT []
synonym: "H(+)-transporting V1 sector ATPase subunit C" EXACT []
synonym: "VAT3" EXACT []
synonym: "VMA5" EXACT []

[Term]
id: sgd:S000001564
name: YKL081W
def: "Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA \(AA-tRNA\) to ribosomes by releasing eEF1A \(Tef1p/Tef2p\) from the ribosomal complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFC1" EXACT []
synonym: "TEF4" EXACT []

[Term]
id: sgd:S000001565
name: YKL082C
def: "Essential protein\, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP14" EXACT []

[Term]
id: sgd:S000001566
name: YKL083W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001567
name: YKL084W
def: "Zinc-binding mitochondrial intermembrane space \(IMS\) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation\, probably by sequestering zinc" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOT13" EXACT []

[Term]
id: sgd:S000001568
name: YKL085W
def: "Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid \(TCA\) cycle; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDH1" EXACT []
synonym: "malate dehydrogenase MDH1" EXACT []

[Term]
id: sgd:S000001569
name: YKL086W
def: "Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p\, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRX1" EXACT []

[Term]
id: sgd:S000001570
name: YKL087C
def: "Cytochrome c1 heme lyase; involved in maturation of cytochrome c1\, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CC1HL" EXACT []
synonym: "CYT2" EXACT []
synonym: "cytochrome c1 heme lyase CYT2" EXACT []

[Term]
id: sgd:S000001571
name: YKL088W
def: "Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase \(PPCDC\) complex are\: Cab3p\, Sis2p\, Vhs3p\, while the subunits of the CoA-synthesizing protein complex \(CoA-SPC\) are\: Cab2p\, Cab3p\, Cab4p\, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAB3" EXACT []
synonym: "phosphopantothenoylcysteine decarboxylase complex subunit CAB3" EXACT []

[Term]
id: sgd:S000001572
name: YKL089W
def: "Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A\, H2B\, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-C and fission yeast cnp3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIF2" EXACT []

[Term]
id: sgd:S000001573
name: YKL090W
def: "Protein of unknown function; has two CUE domains that bind ubiquitin\, which may facilitate intramolecular monoubiquitination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUE2" EXACT []

[Term]
id: sgd:S000001574
name: YKL091C
def: "Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog\, SEC14\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFH1" EXACT []
synonym: "phosphatidylinositol/phosphatidylcholine-binding protein" EXACT []

[Term]
id: sgd:S000001575
name: YKL092C
def: "GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD2" EXACT []
synonym: "CLA2" EXACT []
synonym: "ERC25" EXACT []

[Term]
id: sgd:S000001576
name: YKL093W
def: "Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2\, hap3\, and hap4 mutants; MBR1 has a paralog\, ISF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MBR1" EXACT []

[Term]
id: sgd:S000001577
name: YKL094W
def: "Monoglyceride lipase \(MGL\); functional ortholog of mammalian MGL\, localizes to lipid particles and membranes\, also member of the eukaryotic serine hydrolase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YJU3" EXACT []

[Term]
id: sgd:S000001578
name: YKL095W
def: "Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC \(\"nineteen complex\"\) and acts after Prp2p to promote the first catalytic reaction of splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC16" EXACT []
synonym: "YJU2" EXACT []

[Term]
id: sgd:S000001579
name: YKL096W
def: "Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1\,3- and beta-1\,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWP1" EXACT []
synonym: "YJU1" EXACT []

[Term]
id: sgd:S000001580
name: YKL097C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001581
name: YKL098W
def: "Protein of unknown function; mtc2 is synthetically sick with cdc13-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC2" EXACT []

[Term]
id: sgd:S000001582
name: YKL099C
def: "Subunit of U3-containing Small Subunit \(SSU\) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP11" EXACT []

[Term]
id: sgd:S000001583
name: YKL100C
def: "Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation \(ERAD\) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase \(SPP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPF1" EXACT []

[Term]
id: sgd:S000001584
name: YKL101W
def: "Nim1p-related protein kinase; regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment\, phosphorylation\, and degradation of Swe1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELM2" EXACT []
synonym: "HSL1" EXACT []
synonym: "NIK1" EXACT []
synonym: "protein kinase HSL1" EXACT []

[Term]
id: sgd:S000001585
name: YKL102C
def: "Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001586
name: YKL103C
def: "Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting \(CVT\) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APE1" EXACT []
synonym: "API" EXACT []
synonym: "LAP4" EXACT []
synonym: "YSC1" EXACT []

[Term]
id: sgd:S000001587
name: YKL104C
def: "Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region\, comprising ORFs YMR084W-YMR085W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GFA1" EXACT []
synonym: "glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1" EXACT []

[Term]
id: sgd:S000001588
name: YKL105C
def: "Eisosome component; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog\, SEG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEG2" EXACT []

[Term]
id: sgd:S000001589
name: YKL106W
def: "Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAT1" EXACT []
synonym: "aspartate transaminase AAT1" EXACT []

[Term]
id: sgd:S000001590
name: YKL107W
def: "Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative short-chain dehydrogenase/reductase" EXACT []

[Term]
id: sgd:S000001591
name: YKL108W
def: "Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases \(Cdks\)\, promoting origin binding\, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRC1" EXACT []
synonym: "SLD2" EXACT []

[Term]
id: sgd:S000001592
name: YKL109W
def: "Transcription factor; subunit of the heme-activated\, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex\, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAP4" EXACT []
synonym: "transcription factor HAP4" EXACT []

[Term]
id: sgd:S000001593
name: YKL110C
def: "Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTI12" EXACT []
synonym: "TOT4" EXACT []

[Term]
id: sgd:S000001594
name: YKL111C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001595
name: YKL112W
def: "DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation\, gene silencing\, and DNA replication and repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABF1" EXACT []
synonym: "BAF1" EXACT []
synonym: "DNA-binding protein ABF1" EXACT []
synonym: "OBF1" EXACT []
synonym: "REB2" EXACT []
synonym: "SBF1" EXACT []

[Term]
id: sgd:S000001596
name: YKL113C
def: "5' to 3' exonuclease\, 5' flap endonuclease; required for Okazaki fragment processing and maturation\, for long-patch base-excision repair and large loop repair \(LLR\)\, ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERC11" EXACT []
synonym: "FEN1" EXACT []
synonym: "RAD27" EXACT []
synonym: "RTH1" EXACT []
synonym: "multifunctional nuclease RAD27" EXACT []

[Term]
id: sgd:S000001597
name: YKL114C
def: "Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7\,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APN1" EXACT []
synonym: "DNA-(apurinic or apyrimidinic site) lyase APN1" EXACT []

[Term]
id: sgd:S000001598
name: YKL115C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene PRR1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001599
name: YKL116C
def: "Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK\, possibly at the level of the Ste12p transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRR1" EXACT []
synonym: "serine/threonine protein kinase PRR1" EXACT []

[Term]
id: sgd:S000001600
name: YKL117W
def: "Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins\, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST18" EXACT []
synonym: "SBA1" EXACT []

[Term]
id: sgd:S000001601
name: YKL118W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene VPH2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001602
name: YKL119C
def: "Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase \(V-ATPase\) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum \(ER\); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS10" EXACT []
synonym: "VMA12" EXACT []
synonym: "VPH2" EXACT []

[Term]
id: sgd:S000001603
name: YKL120W
def: "Mitochondrial inner membrane transporter; transports oxaloacetate\, sulfate\, thiosulfate\, and isopropylmalate; member of the mitochondrial carrier family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OAC1" EXACT []

[Term]
id: sgd:S000001604
name: YKL121W
def: "Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog\, YMR102C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DGR2" EXACT []

[Term]
id: sgd:S000001605
name: YKL122C
def: "Subunit of the signal recognition particle \(SRP\); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP21" EXACT []

[Term]
id: sgd:S000001606
name: YKL123W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene SSH4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001607
name: YKL124W
def: "Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion\, increasing steady-state levels of amino acid permeases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLF4" EXACT []
synonym: "SSH4" EXACT []

[Term]
id: sgd:S000001608
name: YKL125W
def: "Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN3" EXACT []

[Term]
id: sgd:S000001609
name: YKL126W
def: "Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p \(inhibitors of serine\:palmitoyl-coenzyme A transferase\) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog\, YPK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLI2" EXACT []
synonym: "YPK1" EXACT []
synonym: "serine/threonine protein kinase YPK1" EXACT []

[Term]
id: sgd:S000001610
name: YKL127W
def: "Phosphoglucomutase\, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate\, which is a key step in hexose metabolism; PGM1 has a paralog\, PGM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGM1" EXACT []
synonym: "phosphoglucomutase PGM1" EXACT []

[Term]
id: sgd:S000001611
name: YKL128C
def: "Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMU1" EXACT []

[Term]
id: sgd:S000001612
name: YKL129C
def: "One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth\, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog\, MYO5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MYO3" EXACT []
synonym: "myosin 3" EXACT []

[Term]
id: sgd:S000001613
name: YKL130C
def: "RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHE2" EXACT []

[Term]
id: sgd:S000001614
name: YKL131W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001615
name: YKL132C
def: "Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog\, FOL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMA1" EXACT []
synonym: "putative tetrahydrofolate synthase" EXACT []

[Term]
id: sgd:S000001616
name: YKL133C
def: "Putative protein of unknown function; not required for growth of cells lacking the mitochondrial genome \(null mutation does not confer a petite-negative phenotype\); YKL133C has a paralog\, MGR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001617
name: YKL134C
def: "Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import\, after their cleavage by mitochondrial processing peptidase \(Mas1p-Mas2p\); may contribute to mitochondrial iron homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCT1" EXACT []

[Term]
id: sgd:S000001618
name: YKL135C
def: "Beta-adaptin subunit of the clathrin-associated protein \(AP-1\) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL2" EXACT []

[Term]
id: sgd:S000001619
name: YKL136W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001620
name: YKL137W
def: "Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMC1" EXACT []

[Term]
id: sgd:S000001621
name: YKL138C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL31" EXACT []
synonym: "YmL31" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL31" EXACT []

[Term]
id: sgd:S000001622
name: YKL139W
def: "Catalytic \(alpha\) subunit of C-terminal domain kinase I \(CTDK-I\); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing\, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTK1" EXACT []
synonym: "cyclin-dependent serine/threonine protein kinase CTK1" EXACT []

[Term]
id: sgd:S000001623
name: YKL140W
def: "Steryl ester hydrolase; one of three gene products \(Yeh1p\, Yeh2p\, Tgl1p\) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TGL1" EXACT []
synonym: "YKL5" EXACT []

[Term]
id: sgd:S000001624
name: YKL141W
def: "Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase\, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog\, SHH3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYB3" EXACT []
synonym: "SDH3" EXACT []
synonym: "YKL4" EXACT []
synonym: "succinate dehydrogenase cytochrome b subunit SDH3" EXACT []

[Term]
id: sgd:S000001625
name: YKL142W
def: "Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP8" EXACT []
synonym: "YKL3" EXACT []

[Term]
id: sgd:S000001626
name: YKL143W
def: "Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTV1" EXACT []
synonym: "YKL2" EXACT []

[Term]
id: sgd:S000001627
name: YKL144C
def: "RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C25" EXACT []
synonym: "DNA-directed RNA polymerase III subunit RPC25" EXACT []
synonym: "RPC25" EXACT []
synonym: "YKL1" EXACT []

[Term]
id: sgd:S000001628
name: YKL145W
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIM5" EXACT []
synonym: "RPT1" EXACT []
synonym: "YTA3" EXACT []
synonym: "proteasome regulatory particle base subunit RPT1" EXACT []

[Term]
id: sgd:S000001629
name: YKL146W
def: "Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT3" EXACT []

[Term]
id: sgd:S000001630
name: YKL147C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001631
name: YKL148C
def: "Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; SDH1 has a paralog\, YJL045W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDH1" EXACT []
synonym: "SDHA" EXACT []
synonym: "succinate dehydrogenase flavoprotein subunit SDH1" EXACT []

[Term]
id: sgd:S000001632
name: YKL149C
def: "RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis \(ALS\)\, suggests potential therapeutic target for ALS and related TDP-43 proteinopathies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBR1" EXACT []
synonym: "PRP26" EXACT []

[Term]
id: sgd:S000001633
name: YKL150W
def: "Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCR1" EXACT []

[Term]
id: sgd:S000001634
name: YKL151C
def: "NADHX dehydratase; converts \(S\)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals\, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes\, prokaryotes and archaea; YKL151C promoter contains STREs \(stress response elements\) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NADHX dehydratase" EXACT []

[Term]
id: sgd:S000001635
name: YKL152C
def: "Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPM1" EXACT []
synonym: "phosphoglycerate mutase GPM1" EXACT []

[Term]
id: sgd:S000001636
name: YKL153W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001637
name: YKL154W
def: "Signal recognition particle \(SRP\) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit\, Srp101p to the ER membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP102" EXACT []
synonym: "Signal recognition particle receptor subunit beta" EXACT []

[Term]
id: sgd:S000001638
name: YKL155C
def: "Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM22" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM22" EXACT []

[Term]
id: sgd:S000001639
name: YKL156W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S27\, no bacterial homolog; RPS27A has a paralog\, RPS27B\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS27A" EXACT []
synonym: "S27A" EXACT []
synonym: "S27e" EXACT []
synonym: "YS20" EXACT []
synonym: "ribosomal 40S subunit protein S27A" EXACT []
synonym: "rp61" EXACT []

[Term]
id: sgd:S000001640
name: YKL157W
def: "Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog\, AAP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APE2" EXACT []
synonym: "LAP1" EXACT []
synonym: "YKL158W" EXACT []

[Term]
id: sgd:S000001642
name: YKL159C
def: "Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCN1" EXACT []

[Term]
id: sgd:S000001643
name: YKL160W
def: "Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus \(BMV\) gene expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELF1" EXACT []

[Term]
id: sgd:S000001644
name: YKL161C
def: "Protein kinase; implicated in Slt2p mitogen-activated \(MAP\) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog\, SLT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KDX1" EXACT []
synonym: "MLP1" EXACT []
synonym: "putative protein kinase KDX1" EXACT []

[Term]
id: sgd:S000001645
name: YKL162C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001646
name: YKL163W
def: "O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated\, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog\, HSP150\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW8" EXACT []
synonym: "PIR3" EXACT []

[Term]
id: sgd:S000001647
name: YKL164C
def: "O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1\,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog\, YJL160C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW6" EXACT []
synonym: "PIR1" EXACT []

[Term]
id: sgd:S000001648
name: YKL165C
def: "Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FSR2" EXACT []
synonym: "MCD4" EXACT []
synonym: "SSU21" EXACT []
synonym: "ZRG16" EXACT []

[Term]
id: sgd:S000001649
name: YKL166C
def: "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog\, TPK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPK3" EXACT []
synonym: "cAMP-dependent protein kinase catalytic subunit TPK3" EXACT []

[Term]
id: sgd:S000001650
name: YKL167C
def: "Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP49" EXACT []
synonym: "mitochondrial 54S ribosomal protein MRP49" EXACT []

[Term]
id: sgd:S000001651
name: YKL168C
def: "Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog\, HAL5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KKQ8" EXACT []
synonym: "putative serine/threonine protein kinase KKQ8" EXACT []

[Term]
id: sgd:S000001652
name: YKL169C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001653
name: YKL170W
def: "Mitochondrial ribosomal protein of the large subunit; appears as two protein spots \(YmL34 and YmL38\) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL34" EXACT []
synonym: "MRPL38" EXACT []
synonym: "YmL34" EXACT []
synonym: "YmL38" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL38/YmL34" EXACT []

[Term]
id: sgd:S000001654
name: YKL171W
def: "Protein kinase; implicated in proteasome function; interacts with TORC1\, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NNK1" EXACT []
synonym: "protein kinase NNK1" EXACT []

[Term]
id: sgd:S000001655
name: YKL172W
def: "Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p\, but is not involved in telomere tethering" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EBP2" EXACT []

[Term]
id: sgd:S000001656
name: YKL173W
def: "GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIN10" EXACT []
synonym: "SNU114" EXACT []
synonym: "U5 snRNP GTPase SNU114" EXACT []

[Term]
id: sgd:S000001657
name: YKL174C
def: "Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPO5" EXACT []

[Term]
id: sgd:S000001658
name: YKL175W
def: "Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZRT3" EXACT []
synonym: "Zn(2+) transporter ZRT3" EXACT []

[Term]
id: sgd:S000001659
name: YKL176C
def: "Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LST4" EXACT []

[Term]
id: sgd:S000001660
name: YKL177W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001661
name: YKL178C
def: "Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells\, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAF2" EXACT []
synonym: "STE3" EXACT []

[Term]
id: sgd:S000001662
name: YKL179C
def: "Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 \(encoding a Golgi snare protein\) suggest a role in Golgi function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COY1" EXACT []

[Term]
id: sgd:S000001663
name: YKL180W
def: "Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex \(aka DASH complex\); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog\, RPL17B\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L17A" EXACT []
synonym: "L20A" EXACT []
synonym: "L22" EXACT []
synonym: "RPL17" EXACT []
synonym: "RPL17A" EXACT []
synonym: "YL17" EXACT []
synonym: "ribosomal 60S subunit protein L17A" EXACT []

[Term]
id: sgd:S000001664
name: YKL181W
def: "5-phospho-ribosyl-1\(alpha\)-pyrophosphate synthetase; synthesizes PRPP\, which is required for nucleotide\, histidine\, and tryptophan biosynthesis; plays a key role in cell wall integrity \(CWI\) pathway; one of five related enzymes\, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth \(CMTX5\) disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP1" EXACT []
synonym: "PRS1" EXACT []
synonym: "ribose phosphate diphosphokinase subunit PRS1" EXACT []

[Term]
id: sgd:S000001665
name: YKL182W
def: "Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase\, dehydratase\, enoyl reductase\, malonyl transacylase\, and palmitoyl transacylase activities" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAS1" EXACT []
synonym: "tetrafunctional fatty acid synthase subunit FAS1" EXACT []

[Term]
id: sgd:S000001666
name: YKL183W
def: "Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOT5" EXACT []

[Term]
id: sgd:S000001667
name: YKL184W
def: "Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan\, and increases necrotic cell death and ROS generation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORD1" EXACT []
synonym: "SPE1" EXACT []
synonym: "SPE10" EXACT []
synonym: "ornithine decarboxylase SPE1" EXACT []

[Term]
id: sgd:S000001668
name: YKL185W
def: "Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells\, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASH1" EXACT []
synonym: "DNA-binding transcription repressor ASH1" EXACT []

[Term]
id: sgd:S000001669
name: YKL186C
def: "mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTR2" EXACT []

[Term]
id: sgd:S000001670
name: YKL187C
def: "Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic\, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog\, YLR413W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAT3" EXACT []

[Term]
id: sgd:S000001671
name: YKL188C
def: "Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy \(X-ALD\)\, a peroxisomal disorder; complex also includes Pxa1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette long-chain fatty acid transporter PXA2" EXACT []
synonym: "PAT1" EXACT []
synonym: "PXA2" EXACT []

[Term]
id: sgd:S000001672
name: YKL189W
def: "Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis\, interacts with Kic1p and Sog2p\, localizes to sites of polarized growth during budding and during the mating response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HYM1" EXACT []

[Term]
id: sgd:S000001673
name: YKL190W
def: "Calcineurin B; regulatory subunit of calcineurin\, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p \(stress-response transcription factor\); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals\, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNB1" EXACT []
synonym: "CRV1" EXACT []
synonym: "YCN2" EXACT []
synonym: "calcineurin regulatory subunit B" EXACT []

[Term]
id: sgd:S000001674
name: YKL191W
def: "Protein required for synthesis of diphthamide; required along with Dph1p\, Kti11p\, Jjj3p\, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 \(Eft1p or Eft2p\); may act in a complex with Dph1p and Kti11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH2" EXACT []

[Term]
id: sgd:S000001675
name: YKL192C
def: "Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate\, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACP1" EXACT []

[Term]
id: sgd:S000001676
name: YKL193C
def: "Regulatory subunit of the type 1 protein phosphatase \(PP1\) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGP1" EXACT []
synonym: "SDS22" EXACT []

[Term]
id: sgd:S000001677
name: YKL194C
def: "Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT\(UGU\)Q1 and the unusual threonine tRNA tT\(UAG\)Q2 in vitro; lacks a typical editing domain\, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MST1" EXACT []
synonym: "threonine--tRNA ligase MST1" EXACT []

[Term]
id: sgd:S000001678
name: YKL195W
def: "Mitochondrial oxidoreductase; involved in mitochondrial intermembrane space import; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p\, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP15" EXACT []
synonym: "MIA40" EXACT []
synonym: "TIM40" EXACT []

[Term]
id: sgd:S000001679
name: YKL196C
def: "Vesicle membrane protein \(v-SNARE\) with acyltransferase activity; involved in trafficking to and within the Golgi\, endocytic trafficking to the vacuole\, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YKT6" EXACT []
synonym: "palmitoyltransferase YKT6" EXACT []

[Term]
id: sgd:S000001680
name: YKL197C
def: "AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase peroxin 1" EXACT []
synonym: "PAS1" EXACT []
synonym: "PEX1" EXACT []

[Term]
id: sgd:S000001681
name: YKL198C
def: "Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog\, PTK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KKT8" EXACT []
synonym: "POT1" EXACT []
synonym: "PTK1" EXACT []
synonym: "STK1" EXACT []
synonym: "YKL199C" EXACT []
synonym: "YKT9" EXACT []
synonym: "putative serine/threonine protein kinase PTK1" EXACT []

[Term]
id: sgd:S000001684
name: YKL201C
def: "Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog\, YJR061W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNN4" EXACT []
synonym: "YKL200C" EXACT []

[Term]
id: sgd:S000001685
name: YKL202W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001686
name: YKL203C
def: "PIK-related protein kinase and rapamycin target; subunit of TORC1\, a complex that regulates growth in response to nutrients and TORC2\, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog\, TOR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRR2" EXACT []
synonym: "TOR2" EXACT []
synonym: "phosphatidylinositol kinase-related protein kinase TOR2" EXACT []

[Term]
id: sgd:S000001687
name: YKL204W
def: "eIF4E-associated protein\, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping\, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth\, implicated in the TOR signaling cascade" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAP1" EXACT []

[Term]
id: sgd:S000001688
name: YKL205W
def: "Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOS1" EXACT []

[Term]
id: sgd:S000001689
name: YKL206C
def: "Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADD66" EXACT []
synonym: "PBA2" EXACT []
synonym: "POC2" EXACT []

[Term]
id: sgd:S000001690
name: YKL207W
def: "Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3\, fly CG6750\, human TMEM111" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM27" EXACT []
synonym: "EMC3" EXACT []
synonym: "LRC3" EXACT []

[Term]
id: sgd:S000001691
name: YKL208W
def: "Protein involved in 5' RNA end processing; substrates include mitochondrial COB\, 15S_rRNA\, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBT1" EXACT []
synonym: "SOC1" EXACT []

[Term]
id: sgd:S000001692
name: YKL209C
def: "Plasma membrane ATP-binding cassette \(ABC\) transporter; required for the export of a-factor\, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette alpha-factor transporter STE6" EXACT []
synonym: "STE6" EXACT []

[Term]
id: sgd:S000001693
name: YKL210W
def: "Ubiquitin activating enzyme \(E1\); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E1 ubiquitin-activating protein UBA1" EXACT []
synonym: "UBA1" EXACT []

[Term]
id: sgd:S000001694
name: YKL211C
def: "Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase\:indole-3-glycerol phosphate synthase enzyme complex with Trp2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRP3" EXACT []
synonym: "bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase" EXACT []

[Term]
id: sgd:S000001695
name: YKL212W
def: "Phosphatidylinositol phosphate \(PtdInsP\) phosphatase; involved in hydrolysis of PtdIns\[4\]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing\, secretion\, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns\(4\)P metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSD1" EXACT []
synonym: "SAC1" EXACT []
synonym: "phosphatidylinositol-3-phosphatase SAC1" EXACT []

[Term]
id: sgd:S000001696
name: YKL213C
def: "WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 \(Cse4p\) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA1" EXACT []
synonym: "UFD3" EXACT []
synonym: "ZZZ4" EXACT []

[Term]
id: sgd:S000001697
name: YKL214C
def: "Member of the REF \(RNA and export factor binding proteins\) family; when overexpressed\, can substitute for the function of Yra1p in export of poly\(A\)+ mRNA from the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YRA2" EXACT []

[Term]
id: sgd:S000001698
name: YKL215C
def: "5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OXP1" EXACT []

[Term]
id: sgd:S000001699
name: YKL216W
def: "Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines\, converting dihydroorotic acid into orotic acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URA1" EXACT []
synonym: "dihydroorotate dehydrogenase" EXACT []

[Term]
id: sgd:S000001700
name: YKL217W
def: "Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate\, pyuvate\, and acetate\, and also of the micronutrient selenite\, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated\, with transcription repression\, mRNA degradation\, and protein endocytosis and degradation all occurring in the presence of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JEN1" EXACT []

[Term]
id: sgd:S000001701
name: YKL218C
def: "3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase \(Srr\) but has no serine racemase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRY1" EXACT []
synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase SRY1" EXACT []

[Term]
id: sgd:S000001702
name: YKL219W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS9" EXACT []

[Term]
id: sgd:S000001703
name: YKL220C
def: "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE2" EXACT []

[Term]
id: sgd:S000001704
name: YKL221W
def: "Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCH2" EXACT []

[Term]
id: sgd:S000001705
name: YKL222C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster \(binuclear cluster\) family; null mutant is sensitive to caffeine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001706
name: YKL223W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001707
name: YKL224C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU16" EXACT []
synonym: "seripauperin PAU16" EXACT []

[Term]
id: sgd:S000001708
name: YKL225W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001709
name: YKR001C
def: "Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization\, endocytosis\, late Golgi-retention of some proteins\, regulation of peroxisome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD1" EXACT []
synonym: "LAM1" EXACT []
synonym: "SPO15" EXACT []
synonym: "VPL1" EXACT []
synonym: "VPS1" EXACT []
synonym: "VPT26" EXACT []
synonym: "dynamin-like GTPase VPS1" EXACT []

[Term]
id: sgd:S000001710
name: YKR002W
def: "Poly\(A\) polymerase; one of three factors required for mRNA 3'-end polyadenylation\, forms multiprotein complex with polyadenylation factor I \(PF I\)\, also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAP1" EXACT []
synonym: "polynucleotide adenylyltransferase PAP1" EXACT []

[Term]
id: sgd:S000001711
name: YKR003W
def: "Member of an oxysterol-binding protein family; overlapping\, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog\, OSH7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSH6" EXACT []
synonym: "oxysterol-binding protein OSH6" EXACT []

[Term]
id: sgd:S000001712
name: YKR004C
def: "Non-essential protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM9" EXACT []
synonym: "YKR004C-A" EXACT []

[Term]
id: sgd:S000001713
name: YKR005C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001714
name: YKR006C
def: "Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL13" EXACT []
synonym: "YK105" EXACT []
synonym: "YmL13" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL13" EXACT []

[Term]
id: sgd:S000001715
name: YKR007W
def: "Component of the EGO and GSE complexes; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGO1" EXACT []
synonym: "GSE2" EXACT []
synonym: "MEH1" EXACT []

[Term]
id: sgd:S000001716
name: YKR008W
def: "Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated \(K25\) by Gcn5p\, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 \(H3K14ac\) by Gcn5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC4" EXACT []

[Term]
id: sgd:S000001717
name: YKR009C
def: "3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOX2" EXACT []
synonym: "POX2" EXACT []
synonym: "bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2" EXACT []

[Term]
id: sgd:S000001718
name: YKR010C
def: "Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog\, NET1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOF2" EXACT []

[Term]
id: sgd:S000001719
name: YKR011C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS5" EXACT []

[Term]
id: sgd:S000001720
name: YKR012C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001721
name: YKR013W
def: "Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily \(cysteine-rich secretory proteins \(CRISP\)\, antigen 5\, and pathogenesis related 1 proteins\); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog\, PRY1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRY2" EXACT []
synonym: "YFW12" EXACT []

[Term]
id: sgd:S000001722
name: YKR014C
def: "Endosomal Rab family GTPase; required for vacuolar protein sorting\, endocytosis and multivesicular body \(MVB\) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT52" EXACT []
synonym: "YPT52" EXACT []

[Term]
id: sgd:S000001723
name: YKR015C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001724
name: YKR016W
def: "Component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space \(IMS\) proteins\, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM28" EXACT []
synonym: "FCJ1" EXACT []
synonym: "FMP13" EXACT []
synonym: "MIC60" EXACT []

[Term]
id: sgd:S000001725
name: YKR017C
def: "RING finger ubiquitin ligase \(E3\); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea \(HU\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase HEL1" EXACT []
synonym: "HEL1" EXACT []

[Term]
id: sgd:S000001726
name: YKR018C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog\, IML2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001727
name: YKR019C
def: "EH domain-containing protein; involved in regulating phosphatidylinositol 4\,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog\, TAX4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRS4" EXACT []

[Term]
id: sgd:S000001728
name: YKR020W
def: "Component of the GARP \(Golgi-associated retrograde protein\) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi\, and for mitosis after DNA damage induced checkpoint arrest; links the \(VFT/GARP\) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p\," []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "API3" EXACT []
synonym: "VPS51" EXACT []
synonym: "VPS67" EXACT []
synonym: "WHI6" EXACT []

[Term]
id: sgd:S000001729
name: YKR021W
def: "Alpha arrestin\, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog\, ALY2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALY1" EXACT []
synonym: "ART6" EXACT []

[Term]
id: sgd:S000001730
name: YKR022C
def: "Essential protein that forms a dimer with Ntr1p; also forms a trimer\, with Ntr2p and the DExD/H-box RNA helicase Prp43p\, that is involved in spliceosome disassembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTR2" EXACT []

[Term]
id: sgd:S000001731
name: YKR023W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001732
name: YKR024C
def: "Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP7" EXACT []

[Term]
id: sgd:S000001733
name: YKR025W
def: "RNA polymerase III subunit C37" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C37" EXACT []
synonym: "RPC37" EXACT []

[Term]
id: sgd:S000001734
name: YKR026C
def: "Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p\, Gcd6p\, Gcd7p\, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAS2" EXACT []
synonym: "GCN3" EXACT []
synonym: "translation initiation factor eIF2B subunit alpha" EXACT []

[Term]
id: sgd:S000001735
name: YKR027W
def: "Member of the ChAPs \(Chs5p-Arf1p-binding proteins\) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins\, including Chs3p\, from the Golgi to the plasma membrane; BCH2 has a paralog\, CHS6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCH2" EXACT []
synonym: "FMP50" EXACT []

[Term]
id: sgd:S000001736
name: YKR028W
def: "Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p\, Sap155p\, and Sap185p; SAP190 has a paralog\, SAP185\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP190" EXACT []

[Term]
id: sgd:S000001737
name: YKR029C
def: "Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog\, SET4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SET3" EXACT []
synonym: "histone-binding protein SET3" EXACT []

[Term]
id: sgd:S000001738
name: YKR030W
def: "Golgi membrane protein of unknown function; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GMH1" EXACT []
synonym: "MSG1" EXACT []

[Term]
id: sgd:S000001739
name: YKR031C
def: "Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine\, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with \"foot domain\" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLD1" EXACT []
synonym: "SPO14" EXACT []
synonym: "phospholipase D" EXACT []

[Term]
id: sgd:S000001740
name: YKR032W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001741
name: YKR033C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001742
name: YKR034W
def: "Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family\, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog\, GZF3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL80" EXACT []
synonym: "UGA43" EXACT []

[Term]
id: sgd:S000001743
name: YKR035C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI8" EXACT []

[Term]
id: sgd:S000001744
name: YKR036C
def: "WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p\, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog\, MDV1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF4" EXACT []

[Term]
id: sgd:S000001745
name: YKR037C
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC34" EXACT []

[Term]
id: sgd:S000001746
name: YKR038C
def: "Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex\, with Bud32p\, Cgi121p\, Pcc1p\, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAE1" EXACT []

[Term]
id: sgd:S000001747
name: YKR039W
def: "General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAP1" EXACT []
synonym: "amino acid permease GAP1" EXACT []

[Term]
id: sgd:S000001748
name: YKR040C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001749
name: YKR041W
def: "Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001750
name: YKR042W
def: "Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis\, the oxidative stress response\, life span during starvation\, and cell death; SUN family member; UTH1 has a paralog\, NCA3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUN family protein UTH1" EXACT []
synonym: "UTH1" EXACT []

[Term]
id: sgd:S000001751
name: YKR043C
def: "Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1\,7-bisphosphate\, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1\,6-bisphosphatase activity but this is probably not biologically relevant\, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHB17" EXACT []

[Term]
id: sgd:S000001752
name: YKR044W
def: "Protein of unknown function that interacts with Ulp1p; a Ubl \(ubiquitin-like protein\)-specific protease for Smt3p protein conjugates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UIP5" EXACT []

[Term]
id: sgd:S000001753
name: YKR045C
def: "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001754
name: YKR046C
def: "Protein of unknown function that localizes to lipid particles; localization suggests a role in lipid metabolism; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET10" EXACT []

[Term]
id: sgd:S000001755
name: YKR047W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001756
name: YKR048C
def: "Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the transport of H2A and H2B histones to the nucleus; required for the regulation of microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAP1" EXACT []
synonym: "histone chaperone NAP1" EXACT []

[Term]
id: sgd:S000001757
name: YKR049C
def: "Putative redox protein containing a thioredoxin fold; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP46" EXACT []

[Term]
id: sgd:S000001758
name: YKR050W
def: "Component of the Trk1p-Trk2p potassium transport system; contributes to K\(+\) supply and maintenance of plasma-membrane potential; TRK2 has a paralog\, TRK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPD2" EXACT []
synonym: "TRK2" EXACT []

[Term]
id: sgd:S000001759
name: YKR051W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001760
name: YKR052C
def: "Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog\, MRS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS4" EXACT []

[Term]
id: sgd:S000001761
name: YKR053C
def: "Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog\, LCB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LBP2" EXACT []
synonym: "YSR3" EXACT []
synonym: "sphinganine kinase YSR3" EXACT []

[Term]
id: sgd:S000001762
name: YKR054C
def: "Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family\, required for anaphase spindle elongation; involved in spindle assembly\, chromosome movement\, and spindle orientation during cell division\, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHC1" EXACT []
synonym: "DYN1" EXACT []
synonym: "PAC6" EXACT []
synonym: "dynein heavy chain" EXACT []

[Term]
id: sgd:S000001763
name: YKR055W
def: "Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHO4" EXACT []
synonym: "Rho family GTPase RHO4" EXACT []

[Term]
id: sgd:S000001764
name: YKR056W
def: "tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUC2" EXACT []
synonym: "NUD1" EXACT []
synonym: "RNC1" EXACT []
synonym: "TRM2" EXACT []

[Term]
id: sgd:S000001765
name: YKR057W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S21\, no bacterial homolog; RPS21A has a paralog\, RPS21B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS21A" EXACT []
synonym: "RPS25" EXACT []
synonym: "S21A" EXACT []
synonym: "S21e" EXACT []
synonym: "S26A" EXACT []
synonym: "YS25" EXACT []
synonym: "ribosomal 40S subunit protein S21A" EXACT []

[Term]
id: sgd:S000001766
name: YKR058W
def: "Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis\, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog\, GLG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLG1" EXACT []
synonym: "glycogenin glucosyltransferase GLG1" EXACT []

[Term]
id: sgd:S000001767
name: YKR059W
def: "Translation initiation factor eIF4A; DEA\(D/H\)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog\, TIF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF1" EXACT []
synonym: "eIF4A" EXACT []
synonym: "translation initiation factor eIF4A" EXACT []

[Term]
id: sgd:S000001768
name: YKR060W
def: "Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP30" EXACT []

[Term]
id: sgd:S000001769
name: YKR061W
def: "Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog\, YUR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR2" EXACT []
synonym: "mannosyltransferase KTR2" EXACT []

[Term]
id: sgd:S000001770
name: YKR062W
def: "TFIIE small subunit; involved in RNA polymerase II transcription initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFA2" EXACT []

[Term]
id: sgd:S000001771
name: YKR063C
def: "Protein required for pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAS1" EXACT []

[Term]
id: sgd:S000001772
name: YKR064W
def: "Putative transcriptional repressor with Zn\(2\)-Cys\(6\) finger; negatively regulates transcription in response to oleate levels\, based on mutant phenotype and localization to oleate-responsive promoters; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OAF3" EXACT []

[Term]
id: sgd:S000001773
name: YKR065C
def: "Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor \(PAM complex\) or to interact with and modulate the core TIM23 \(Translocase of the Inner mitochondrial Membrane\) complex; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP18" EXACT []
synonym: "PAM17" EXACT []

[Term]
id: sgd:S000001774
name: YKR066C
def: "Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria\, involved in the response to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCP1" EXACT []

[Term]
id: sgd:S000001775
name: YKR067W
def: "Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT1" EXACT []
synonym: "GPT2" EXACT []
synonym: "bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2" EXACT []

[Term]
id: sgd:S000001776
name: YKR068C
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BET3" EXACT []
synonym: "TRAPP complex core subunit BET3" EXACT []

[Term]
id: sgd:S000001777
name: YKR069W
def: "S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme\, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET1" EXACT []
synonym: "MET20" EXACT []
synonym: "uroporphyrinogen-III C-methyltransferase" EXACT []

[Term]
id: sgd:S000001778
name: YKR070W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001779
name: YKR071C
def: "Component of the cytosolic Fe-S protein assembly \(CIA\) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRE2" EXACT []

[Term]
id: sgd:S000001780
name: YKR072C
def: "Negative regulatory subunit of protein phosphatase 1 \(Ppz1p\); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase \(PPCDC\: Cab3p\, Sis2p\, Vhs3p\) complex and the CoA-Synthesizing Protein Complex \(CoA-SPC\: Cab2p\, Cab3p\, Cab4p\, Cab5p\, Sis2p and Vhs3p\); SIS2 has a paralog\, VHS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL3" EXACT []
synonym: "SIS2" EXACT []
synonym: "phosphopantothenoylcysteine decarboxylase complex subunit SIS2" EXACT []

[Term]
id: sgd:S000001781
name: YKR073C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001782
name: YKR074W
def: "Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM29" EXACT []

[Term]
id: sgd:S000001783
name: YKR075C
def: "Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog\, YOR062C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001784
name: YKR076W
def: "Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM4" EXACT []
synonym: "GTO2" EXACT []

[Term]
id: sgd:S000001785
name: YKR077W
def: "Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog\, MSA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSA2" EXACT []

[Term]
id: sgd:S000001786
name: YKR078W
def: "Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology \(PX\) domain and specifically binds phosphatidylinositol 3-phosphate \(PtdIns-3-P\); YKR078W has a paralog\, VPS5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001787
name: YKR079C
def: "tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRZ1" EXACT []

[Term]
id: sgd:S000001788
name: YKR080W
def: "NAD-dependent 5\,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p\, repressed by adenine\, and may be induced by inositol and choline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTD1" EXACT []
synonym: "methylenetetrahydrofolate dehydrogenase (NAD(+))" EXACT []

[Term]
id: sgd:S000001789
name: YKR081C
def: "Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPF2" EXACT []

[Term]
id: sgd:S000001790
name: YKR082W
def: "Subunit of Nup84p subcomplex of nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport\, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery\, including double-strand break repair\, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP133" EXACT []
synonym: "RAT3" EXACT []

[Term]
id: sgd:S000001791
name: YKR083C
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAD2" EXACT []
synonym: "HSK1" EXACT []

[Term]
id: sgd:S000001792
name: YKR084C
def: "GTPase with similarity to translation release factors; together with binding partner Dom34p\, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled\, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog\, SKI7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HBS1" EXACT []
synonym: "ribosome dissociation factor GTPase HBS1" EXACT []

[Term]
id: sgd:S000001793
name: YKR085C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL20" EXACT []
synonym: "YmL20" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL20" EXACT []

[Term]
id: sgd:S000001794
name: YKR086W
def: "DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP\, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAH-box RNA helicase PRP16" EXACT []
synonym: "PRP16" EXACT []
synonym: "PRP23" EXACT []
synonym: "RNA16" EXACT []

[Term]
id: sgd:S000001795
name: YKR087C
def: "Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults and preservation of normal mitochondrial function under damage-eliciting conditions; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OMA1" EXACT []

[Term]
id: sgd:S000001796
name: YKR088C
def: "Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TVP38" EXACT []

[Term]
id: sgd:S000001797
name: YKR089C
def: "Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase\, steryl ester hydrolase\, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog\, TGL5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STC1" EXACT []
synonym: "TGL4" EXACT []

[Term]
id: sgd:S000001798
name: YKR090W
def: "Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites\, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PXL1" EXACT []

[Term]
id: sgd:S000001799
name: YKR091W
def: "GTB motif \(G1/S transcription factor binding\) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed\, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog\, WHI5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding protein SRL3" EXACT []
synonym: "SRL3" EXACT []
synonym: "WHI7" EXACT []

[Term]
id: sgd:S000001800
name: YKR092C
def: "Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles \(snoRNPs\); immunologically and structurally to rat Nopp140" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP40" EXACT []

[Term]
id: sgd:S000001801
name: YKR093W
def: "Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTR2" EXACT []

[Term]
id: sgd:S000001802
name: YKR094C
def: "Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40\, no bacterial homolog; RPL40B has a paralog\, RPL40A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEP52B" EXACT []
synonym: "L40B" EXACT []
synonym: "L40e" EXACT []
synonym: "RPL40B" EXACT []
synonym: "UB12" EXACT []
synonym: "UBI2" EXACT []
synonym: "ubiquitin-ribosomal 60S subunit protein L40B fusion protein" EXACT []

[Term]
id: sgd:S000001803
name: YKR095W
def: "Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog\, MLP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLP1" EXACT []
synonym: "MPL1" EXACT []

[Term]
id: sgd:S000001804
name: YKR096W
def: "Protein of unknown function; interacts with Pex14p; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain; ESL2 has a paralog\, ESL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESL2" EXACT []

[Term]
id: sgd:S000001805
name: YKR097W
def: "Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis\, catalyzes early reaction in carbohydrate biosynthesis\, glucose represses transcription and accelerates mRNA degradation\, regulated by Mcm1p and Cat8p\, located in the cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JPM2" EXACT []
synonym: "PCK1" EXACT []
synonym: "PPC1" EXACT []
synonym: "phosphoenolpyruvate carboxykinase PCK1" EXACT []

[Term]
id: sgd:S000001806
name: YKR098C
def: "Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog\, UBP7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP11" EXACT []

[Term]
id: sgd:S000001807
name: YKR099W
def: "Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAS1" EXACT []

[Term]
id: sgd:S000001808
name: YKR100C
def: "Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog\, AIM20\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKG1" EXACT []
synonym: "YKR099C-A" EXACT []

[Term]
id: sgd:S000001809
name: YKR101W
def: "Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p\, through a common Sir1p domain; binds to centromeric chromatin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIR1" EXACT []

[Term]
id: sgd:S000001810
name: YKR102W
def: "Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose\, sucrose\, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLO10" EXACT []

[Term]
id: sgd:S000001811
name: YKR103W
def: "Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NFT1" EXACT []
synonym: "putative multidrug transporter NFT1" EXACT []

[Term]
id: sgd:S000001812
name: YKR104W
def: "Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NFT1" EXACT []

[Term]
id: sgd:S000001813
name: YKR105C
def: "Plasma membrane protein of the Major Facilitator Superfamily \(MFS\); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog\, VBA3\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VBA5" EXACT []

[Term]
id: sgd:S000001814
name: YKR106W
def: "Proton\:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog\, GEX1\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEX2" EXACT []

[Term]
id: sgd:S000001817
name: YAL065C
def: "Putative protein of unknown function; has homology to FLO1; possible pseudogene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001821
name: YAR030C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001826
name: YFL068W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001827
name: YFL067W
def: "Protein of unknown function; down-regulated at low calcium levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001828
name: YFL066C
def: "Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000001829
name: YFL065C
def: "Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001830
name: YFL064C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001831
name: YFL063W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001832
name: YFL062W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS4" EXACT []

[Term]
id: sgd:S000001833
name: YFL061W
def: "Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDI2" EXACT []

[Term]
id: sgd:S000001834
name: YFL060C
def: "Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNO3" EXACT []

[Term]
id: sgd:S000001835
name: YFL059W
def: "Member of a stationary phase-induced gene family; expressed in the presence of galactose; transcription of SNZ3 is induced prior to diauxic shift\, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNZ3" EXACT []
synonym: "pyridoxine biosynthesis protein SNZ3" EXACT []

[Term]
id: sgd:S000001836
name: YFL058W
def: "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5\, THI11\, THI12\, and THI13; hydroxymethylpyrimidine is also known as HMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI5" EXACT []

[Term]
id: sgd:S000001839
name: YFL055W
def: "Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGP3" EXACT []

[Term]
id: sgd:S000001840
name: YFL054C
def: "Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001841
name: YFL053W
def: "Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone \(DHA\); involved in stress adaptation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAK2" EXACT []

[Term]
id: sgd:S000001842
name: YFL052W
def: "Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White\, low osmolarity\, and heat\, suggesting a role for YFL052Wp in cell wall integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding domain containing protein" EXACT []
synonym: "ROP1" EXACT []

[Term]
id: sgd:S000001843
name: YFL051C
def: "Putative protein of unknown function; YFL051C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001844
name: YFL050C
def: "Probable Mg\(2+\) transporter; overexpression confers increased tolerance to Al\(3+\) and Ga\(3+\) ions; plays a role in regulating Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALR2" EXACT []
synonym: "putative Mg(2+) transporter ALR2" EXACT []

[Term]
id: sgd:S000001845
name: YFL049W
def: "Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWP82" EXACT []

[Term]
id: sgd:S000001846
name: YFL048C
def: "Integral membrane component of ER-derived COPII-coated vesicles; functionS in ER to Golgi transport; EMP47 has a paralog\, EMP46\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMP47" EXACT []

[Term]
id: sgd:S000001847
name: YFL047W
def: "GTPase-activating protein \(RhoGAP\) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGD2" EXACT []

[Term]
id: sgd:S000001848
name: YFL046W
def: "Putative assembly factor for cytochrome c oxidase; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; has similarity to human MCUR1/CCDC90A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP32" EXACT []

[Term]
id: sgd:S000001849
name: YFL045C
def: "Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALG4" EXACT []
synonym: "SEC53" EXACT []
synonym: "phosphomannomutase SEC53" EXACT []

[Term]
id: sgd:S000001850
name: YFL044C
def: "Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor \(OTU\) family; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OTU1" EXACT []
synonym: "YOD1" EXACT []

[Term]
id: sgd:S000001852
name: YFL042C
def: "Putative protein of unknown function; not an essential gene; YFL042C has a paralog\, YLR072W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YFL043C" EXACT []

[Term]
id: sgd:S000001853
name: YFL041W
def: "Multicopper oxidase; integral membrane protein with similarity to Fet3p; may have a role in iron transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FET5" EXACT []
synonym: "ferroxidase FET5" EXACT []

[Term]
id: sgd:S000001854
name: YFL040W
def: "Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001855
name: YFL039C
def: "Actin; structural protein involved in cell polarization\, endocytosis\, and other cytoskeletal functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABY1" EXACT []
synonym: "ACT1" EXACT []
synonym: "END7" EXACT []
synonym: "actin" EXACT []

[Term]
id: sgd:S000001856
name: YFL038C
def: "Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II \(Bet2p-Bet4p\); binds to unspliced HAC1 mRNA; regulates unfolded protein response \(UPR\) by promoting the decay of HAC1 RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT1" EXACT []
synonym: "YP2" EXACT []
synonym: "YPT1" EXACT []

[Term]
id: sgd:S000001857
name: YFL037W
def: "Beta-tubulin; associates with alpha-tubulin \(Tub1p and Tub3p\) to form tubulin dimer\, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles \(CFEOM\) with polymicrogyria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARM10" EXACT []
synonym: "SHE8" EXACT []
synonym: "TUB2" EXACT []
synonym: "beta-tubulin" EXACT []

[Term]
id: sgd:S000001858
name: YFL036W
def: "Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex\, enhancing DNA bending and melting to facilitate pre-initiation open complex formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPO41" EXACT []

[Term]
id: sgd:S000001859
name: YFL034C-B
def: "Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOB2" EXACT []
synonym: "YFL035C" EXACT []
synonym: "YFL035C-A" EXACT []

[Term]
id: sgd:S000001860
name: YFL034W
def: "Putative integral membrane protein that interacts with Rpp0p; Rpp0p is a component of the ribosomal stalk" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001861
name: YFL033C
def: "Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients\, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM15" EXACT []
synonym: "TAK1" EXACT []
synonym: "protein kinase RIM15" EXACT []

[Term]
id: sgd:S000001862
name: YFL032W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001863
name: YFL031W
def: "Basic leucine zipper \(bZIP\) transcription factor \(ATF/CREB1 homolog\); regulates the unfolded protein response\, via UPRE binding\, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERN4" EXACT []
synonym: "HAC1" EXACT []
synonym: "IRE15" EXACT []
synonym: "transcription factor HAC1" EXACT []

[Term]
id: sgd:S000001864
name: YFL030W
def: "Alanine\:glyoxylate aminotransferase \(AGT\); catalyzes the synthesis of glycine from glyoxylate\, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine\:glyoxylate aminotransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGX1" EXACT []
synonym: "alanine--glyoxylate transaminase" EXACT []

[Term]
id: sgd:S000001865
name: YFL029C
def: "Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAK1" EXACT []
synonym: "CIV1" EXACT []
synonym: "cyclin-dependent protein kinase-activating kinase CAK1" EXACT []

[Term]
id: sgd:S000001866
name: YFL028C
def: "Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF16" EXACT []
synonym: "putative ATP-binding cassette family ATPase CAF16" EXACT []

[Term]
id: sgd:S000001867
name: YFL027C
def: "GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p\, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP8" EXACT []

[Term]
id: sgd:S000001868
name: YFL026W
def: "Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE2" EXACT []
synonym: "alpha-factor pheromone receptor STE2" EXACT []

[Term]
id: sgd:S000001869
name: YFL025C
def: "GPI inositol deacylase of the endoplasmic reticulum \(ER\); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1\, mutation of which is associated with intellectual disability and encephalopathy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BST1" EXACT []
synonym: "PER17" EXACT []

[Term]
id: sgd:S000001870
name: YFL024C
def: "Subunit of NuA4\, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC \(nucleosome core particle\); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPL1" EXACT []

[Term]
id: sgd:S000001871
name: YFL023W
def: "Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I\, II\, and III in an Rpb5p-dependent manner; shuttles between nucleus and cytoplasm; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD27" EXACT []
synonym: "URI1" EXACT []

[Term]
id: sgd:S000001872
name: YFL022C
def: "Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence\, but substrate binding is similar" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRS2" EXACT []
synonym: "phenylalanine--tRNA ligase subunit alpha" EXACT []

[Term]
id: sgd:S000001873
name: YFL021W
def: "Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT1" EXACT []
synonym: "MEP80" EXACT []
synonym: "NIL1" EXACT []

[Term]
id: sgd:S000001874
name: YFL020C
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU5" EXACT []
synonym: "seripauperin PAU5" EXACT []

[Term]
id: sgd:S000001875
name: YFL019C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YFL019C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001876
name: YFL018C
def: "Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component \(E3\) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix\, often near the ERMES complex and near peroxisomes; LPD1 has a paralog\, IRC15\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPD1" EXACT []
synonym: "LPD1" EXACT []
synonym: "dihydrolipoyl dehydrogenase" EXACT []

[Term]
id: sgd:S000001877
name: YFL017C
def: "Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START\, DNA synthesis\, and mitosis; involved in UDP-N-acetylglucosamine synthesis\, forms GlcNAc6P from AcCoA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GNA1" EXACT []
synonym: "PAT1" EXACT []
synonym: "glucosamine 6-phosphate N-acetyltransferase" EXACT []

[Term]
id: sgd:S000001878
name: YFL016C
def: "Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 \(DnaJ\) family of chaperones" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDJ1" EXACT []

[Term]
id: sgd:S000001879
name: YFL015C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001880
name: YFL014W
def: "Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock\, oxidative stress\, osmostress\, stationary phase\, glucose depletion\, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLP1" EXACT []
synonym: "HOR5" EXACT []
synonym: "HSP12" EXACT []
synonym: "lipid-binding protein HSP12" EXACT []

[Term]
id: sgd:S000001881
name: YFL013C
def: "Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES1" EXACT []

[Term]
id: sgd:S000001882
name: YFL012W
def: "Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001883
name: YFL011W
def: "Putative hexose transporter; expressed at low levels and expression is repressed by glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT10" EXACT []
synonym: "hexose transporter HXT10" EXACT []

[Term]
id: sgd:S000001884
name: YFL010C
def: "WW domain containing protein of unknown function; binds to Mca1p\, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WWM1" EXACT []

[Term]
id: sgd:S000001885
name: YFL009W
def: "F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF \(Cdc53p\, Skp1p and Hrt1p/Rbx1p\) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase \(CDK\) phosphorylated substrates\, such as\: Sic1p\, Far1p\, Cdc6p\, Clb6p\, and Cln3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC4" EXACT []
synonym: "SCF ubiquitin ligase complex subunit CDC4" EXACT []

[Term]
id: sgd:S000001886
name: YFL008W
def: "Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member\, binds DNA with a preference for DNA with secondary structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL10" EXACT []
synonym: "SMC1" EXACT []
synonym: "cohesin subunit SMC1" EXACT []

[Term]
id: sgd:S000001887
name: YFL007W
def: "Proteasome activator; binds the core proteasome \(CP\) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule \(PSG\) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin\, may be involved in protecting against oxidative damage; similar to mammalian PA200" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLM10" EXACT []
synonym: "YFL006W" EXACT []

[Term]
id: sgd:S000001889
name: YFL005W
def: "Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase SEC4" EXACT []
synonym: "SEC4" EXACT []
synonym: "SRO6" EXACT []

[Term]
id: sgd:S000001890
name: YFL004W
def: "Subunit of vacuolar transporter chaperone \(VTC\) complex; involved in membrane trafficking\, vacuolar polyphosphate accumulation\, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog\, VTC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM1" EXACT []
synonym: "VTC2" EXACT []

[Term]
id: sgd:S000001891
name: YFL003C
def: "Protein involved in meiotic recombination; required for normal levels of crossing over\, colocalizes with Zip2p to discrete foci on meiotic chromosomes\, has homology to bacterial MutS protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH4" EXACT []
synonym: "MutS family protein MSH4" EXACT []

[Term]
id: sgd:S000001894
name: YFL002C
def: "Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPB4" EXACT []

[Term]
id: sgd:S000001895
name: YFL001W
def: "tRNA\:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficiency and normal cell growth\, localizes to both the nucleus and cytoplasm; non-essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEG1" EXACT []
synonym: "HRM3" EXACT []
synonym: "PUS3" EXACT []
synonym: "pseudouridine synthase DEG1" EXACT []

[Term]
id: sgd:S000001897
name: YFR001W
def: "Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag\:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOC1" EXACT []

[Term]
id: sgd:S000001898
name: YFR002W
def: "Linker nucleoporin component of the nuclear pore complex \(NPC\); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins \(Nsp1p\, Nup57p\, and Nup49p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIC96" EXACT []
synonym: "linker nucleoporin NIC96" EXACT []

[Term]
id: sgd:S000001899
name: YFR003C
def: "Regulatory subunit of the type I protein phosphatase \(PP1\) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity\, while overproduction confers lithium-tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPI1" EXACT []

[Term]
id: sgd:S000001900
name: YFR004W
def: "Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved\, independent of catalytic activity\, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPR1" EXACT []
synonym: "RPN11" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN11" EXACT []

[Term]
id: sgd:S000001901
name: YFR005C
def: "Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAD1" EXACT []

[Term]
id: sgd:S000001902
name: YFR006W
def: "Putative X-Pro aminopeptidase; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative Xaa-Pro dipeptidase" EXACT []

[Term]
id: sgd:S000001903
name: YFR007W
def: "Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM12" EXACT []
synonym: "YFH7" EXACT []

[Term]
id: sgd:S000001904
name: YFR008W
def: "Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p\, Far8p\, Far9p\, Far10p\, and Far11p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR7" EXACT []

[Term]
id: sgd:S000001905
name: YFR009W
def: "Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCN20" EXACT []
synonym: "putative AAA family ATPase GCN20" EXACT []

[Term]
id: sgd:S000001906
name: YFR010W
def: "Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome\, releases free ubiquitin from branched polyubiquitin chains; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP6" EXACT []

[Term]
id: sgd:S000001907
name: YFR011C
def: "Component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM13" EXACT []
synonym: "MCS19" EXACT []
synonym: "MIC19" EXACT []

[Term]
id: sgd:S000001908
name: YFR012W
def: "Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog\, YOL019W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCV1" EXACT []

[Term]
id: sgd:S000001909
name: YFR013W
def: "Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog\, ESC8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IOC3" EXACT []

[Term]
id: sgd:S000001910
name: YFR014C
def: "Calmodulin-dependent protein kinase; may play a role in stress response\, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro\, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog\, CMK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMK1" EXACT []
synonym: "calmodulin-dependent protein kinase CMK1" EXACT []

[Term]
id: sgd:S000001911
name: YFR015C
def: "Glycogen synthase; expression induced by glucose limitation\, nitrogen starvation\, environmental stress\, and entry into stationary phase; GSY1 has a paralog\, GSY2\, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSY1" EXACT []
synonym: "glycogen (starch) synthase GSY1" EXACT []

[Term]
id: sgd:S000001912
name: YFR016C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFR016C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001913
name: YFR017C
def: "Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog\, YOL024W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IGD1" EXACT []

[Term]
id: sgd:S000001914
name: YFR018C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001915
name: YFR019W
def: "1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol \(3\,5\)P2\, which is involved in vacuolar sorting and homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-phosphatidylinositol-3-phosphate 5-kinase" EXACT []
synonym: "FAB1" EXACT []
synonym: "SVL7" EXACT []

[Term]
id: sgd:S000001916
name: YFR020W
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001917
name: YFR021W
def: "Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting \(Cvt\) pathway; binds both phosphatidylinositol \(3\,5\)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1\, WIPI2\, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG18" EXACT []
synonym: "AUT10" EXACT []
synonym: "CVT18" EXACT []
synonym: "NMR1" EXACT []
synonym: "SVP1" EXACT []
synonym: "phosphoinositide binding protein ATG18" EXACT []

[Term]
id: sgd:S000001918
name: YFR022W
def: "Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; ROG3 has a paralog\, ROD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART7" EXACT []
synonym: "ROG3" EXACT []

[Term]
id: sgd:S000001919
name: YFR023W
def: "Poly\(A\) binding protein\, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog\, MIP6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PES4" EXACT []

[Term]
id: sgd:S000001921
name: YFR025C
def: "Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu\, Co\, and Ni salts; transcription is regulated by general amino acid control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIS2" EXACT []
synonym: "histidinol-phosphatase" EXACT []

[Term]
id: sgd:S000001922
name: YFR026C
def: "Putative protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response \(UPR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ULI1" EXACT []

[Term]
id: sgd:S000001923
name: YFR027W
def: "Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases \(Cdc28p\, Cdc7p\, Mck1p\) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTF7" EXACT []
synonym: "ECO1" EXACT []

[Term]
id: sgd:S000001924
name: YFR028C
def: "Protein phosphatase required for mitotic exit; required for rDNA segregation\, cytokinesis\, meiosis I spindle disassembly\, and environmental stress response; maintained in nucleolus by Cdc55p in early meiosis until liberated by the FEAR and Mitotic Exit Network in anaphase\, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II\, then released again upon entry into anaphase II" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC14" EXACT []
synonym: "OAF3" EXACT []
synonym: "phosphoprotein phosphatase CDC14" EXACT []

[Term]
id: sgd:S000001925
name: YFR029W
def: "Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p\, Ptr3p\, and Ssy5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTR3" EXACT []
synonym: "RAA2" EXACT []
synonym: "SSY3" EXACT []

[Term]
id: sgd:S000001926
name: YFR030W
def: "Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET10" EXACT []
synonym: "sulfite reductase subunit alpha" EXACT []

[Term]
id: sgd:S000001927
name: YFR031C
def: "Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity\, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMC2" EXACT []
synonym: "condensin subunit SMC2" EXACT []

[Term]
id: sgd:S000001928
name: YFR032C
def: "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT5" EXACT []

[Term]
id: sgd:S000001929
name: YFR033C
def: "Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex\, also known as the cytochrome bc\(1\) complex or Complex III\, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COR3" EXACT []
synonym: "QCR6" EXACT []
synonym: "UCR6" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 6" EXACT []

[Term]
id: sgd:S000001930
name: YFR034C
def: "Basic helix-loop-helix \(bHLH\) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction\, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO4" EXACT []
synonym: "phoD" EXACT []
synonym: "phosphate-sensing transcription factor PHO4" EXACT []

[Term]
id: sgd:S000001931
name: YFR035C
def: "Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001932
name: YFR036W
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC26" EXACT []
synonym: "HIT3" EXACT []
synonym: "SCD26" EXACT []
synonym: "anaphase promoting complex subunit CDC26" EXACT []

[Term]
id: sgd:S000001933
name: YFR037C
def: "Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p\, but unlike Swi3p\, does not activate transcription of reporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC8" EXACT []
synonym: "SWH3" EXACT []

[Term]
id: sgd:S000001934
name: YFR038W
def: "Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC5" EXACT []

[Term]
id: sgd:S000001935
name: YFR039C
def: "Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog\, SHE10\, that arose from the whole genome duplication; deletion of both OSW7 and SHE10 results in reduced dityrosine fluorescence from the spore wall relative to other mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSW7" EXACT []

[Term]
id: sgd:S000001936
name: YFR040W
def: "Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p\, Sap185p\, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog\, SAP4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP155" EXACT []

[Term]
id: sgd:S000001937
name: YFR041C
def: "Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERJ5" EXACT []

[Term]
id: sgd:S000001938
name: YFR042W
def: "Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1\,6-glucan in the cell wall; required for cell viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEG1" EXACT []

[Term]
id: sgd:S000001939
name: YFR043C
def: "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC6" EXACT []

[Term]
id: sgd:S000001940
name: YFR044C
def: "Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione \(GSH\) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase \(Ecm38p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUG1" EXACT []
synonym: "metallodipeptidase" EXACT []

[Term]
id: sgd:S000001941
name: YFR045W
def: "Putative mitochondrial transport protein; null mutant is viable\, exhibits decreased levels of chitin and normal resistance to calcofluor white" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001942
name: YFR046C
def: "Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1\, Mps1p\, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNN1" EXACT []

[Term]
id: sgd:S000001943
name: YFR047C
def: "Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA6" EXACT []
synonym: "QPT1" EXACT []
synonym: "nicotinate-nucleotide diphosphorylase (carboxylating)" EXACT []

[Term]
id: sgd:S000001944
name: YFR048W
def: "Cytosolic protein required for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMD8" EXACT []

[Term]
id: sgd:S000001945
name: YFR049W
def: "Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit \(Lpd1p\) to the E1-E2 \(Kgd1p\, Kgd2p\) core; has similarity to human mitochondrial ribosomal protein MRP-S36" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KGD4" EXACT []
synonym: "YMR31" EXACT []
synonym: "mitochondrial 37S ribosomal protein YMR31" EXACT []

[Term]
id: sgd:S000001946
name: YFR050C
def: "Beta 7 subunit of the 20S proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE4" EXACT []
synonym: "proteasome core particle subunit beta 7" EXACT []

[Term]
id: sgd:S000001947
name: YFR051C
def: "Delta subunit of the coatomer complex \(COPI\); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RET2" EXACT []

[Term]
id: sgd:S000001948
name: YFR052W
def: "Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1\, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIN1" EXACT []
synonym: "RPN12" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN12" EXACT []

[Term]
id: sgd:S000001949
name: YFR053C
def: "Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog\, HXK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXK1" EXACT []
synonym: "hexokinase 1" EXACT []

[Term]
id: sgd:S000001950
name: YFR054C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001951
name: YFR056C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001952
name: YFR055W
def: "Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3\, GAT1-dependent manner and by copper levels in a Mac1-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC7" EXACT []
synonym: "cysteine-S-conjugate beta-lyase IRC7" EXACT []

[Term]
id: sgd:S000001953
name: YFR057W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000001954
name: YER044C-A
def: "Meiosis-specific protein involved in forming DSBs; involved in double-strand break \(DSBs\) formation during meiotic recombination; required for chromosome synapsis and production of viable spores" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEI4" EXACT []

[Term]
id: sgd:S000001955
name: YFL010W-A
def: "Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AUA1" EXACT []
synonym: "YFL011W-A" EXACT []

[Term]
id: sgd:S000001956
name: YKL096W-A
def: "Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWP2" EXACT []
synonym: "LPR1" EXACT []
synonym: "YKL097W-A" EXACT []

[Term]
id: sgd:S000001957
name: YHR079C-A
def: "Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAE3" EXACT []
synonym: "YHR079BC" EXACT []
synonym: "YHR079C-B" EXACT []

[Term]
id: sgd:S000002100
name: YHR039C-A
def: "Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase \(V-ATPase\) has eight subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V1 sector ATPase subunit G" EXACT []
synonym: "VMA10" EXACT []
synonym: "YHR039BC" EXACT []
synonym: "YHR039C-B" EXACT []

[Term]
id: sgd:S000002101
name: YKL006C-A
def: "Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFT1" EXACT []

[Term]
id: sgd:S000002103
name: YEL017C-A
def: "Proteolipid associated with plasma membrane H\(+\)-ATPase \(Pma1p\); regulates plasma membrane H\(+\)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog\, PMP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMP2" EXACT []

[Term]
id: sgd:S000002104
name: YFR031C-A
def: "Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog\, RPL2B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L2" EXACT []
synonym: "L2A" EXACT []
synonym: "L5A" EXACT []
synonym: "RPL2A" EXACT []
synonym: "RPL5B" EXACT []
synonym: "YL6" EXACT []
synonym: "ribosomal 60S subunit protein L2A" EXACT []
synonym: "rp8" EXACT []

[Term]
id: sgd:S000002127
name: YER019C-A
def: "Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog\, SBH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor SBH2" EXACT []
synonym: "SBH2" EXACT []
synonym: "SEB2" EXACT []

[Term]
id: sgd:S000002128
name: YER087C-B
def: "Beta subunit of Sec61p ER translocation complex \(Sec61p-Sss1p-Sbh1p\); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog\, SBH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor SBH1" EXACT []
synonym: "SBH1" EXACT []
synonym: "SEB1" EXACT []
synonym: "YER087C-A" EXACT []

[Term]
id: sgd:S000002129
name: YAR002C-A
def: "Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms heterotrimeric complex with Erp2p\, Emp24p\, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog\, ERP6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP1" EXACT []

[Term]
id: sgd:S000002133
name: YCR079W
def: "Mitochondrial type 2C protein phosphatase \(PP2C\); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AUP1" EXACT []
synonym: "PPP2" EXACT []
synonym: "PTC6" EXACT []
synonym: "type 2C protein phosphatase PTC6" EXACT []

[Term]
id: sgd:S000002134
name: YAL034C
def: "Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog\, YOR338W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN19" EXACT []

[Term]
id: sgd:S000002135
name: YER056C-A
def: "Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34\, no bacterial homolog; RPL34A has a paralog\, RPL34B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L34A" EXACT []
synonym: "L34e" EXACT []
synonym: "RPL34A" EXACT []
synonym: "ribosomal 60S subunit protein L34A" EXACT []

[Term]
id: sgd:S000002136
name: YAL004W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002137
name: YAL034C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAL035C-A" EXACT []

[Term]
id: sgd:S000002138
name: YAL042C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAL043C-A" EXACT []

[Term]
id: sgd:S000002139
name: YAL056C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAL058C-A" EXACT []

[Term]
id: sgd:S000002140
name: YAL064C-A
def: "Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA8" EXACT []
synonym: "YAL065C-A" EXACT []

[Term]
id: sgd:S000002141
name: YAL064W-B
def: "Fungal-specific protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002142
name: YAL068C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU8" EXACT []
synonym: "seripauperin PAU8" EXACT []

[Term]
id: sgd:S000002143
name: YAL069W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002144
name: YAR066W
def: "Putative GPI protein; YAR066W has a paralog\, YHR214W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002145
name: YAR075W
def: "Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog\, IMD2\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002150
name: YBL109W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002151
name: YBL111C
def: "Helicase-like protein encoded within the telomeric Y' element; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002152
name: YBL112C
def: "Putative protein of unknown function; YBL112C is contained within TEL02L" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002153
name: YBL113C
def: "Helicase-like protein encoded within the telomeric Y' element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002156
name: YBR084C-A
def: "Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth\, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19\, no bacterial homolog; RPL19A has a paralog\, RPL19B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L19A" EXACT []
synonym: "L19e" EXACT []
synonym: "L23A" EXACT []
synonym: "RPL19A" EXACT []
synonym: "YL14" EXACT []
synonym: "ribosomal 60S subunit protein L19A" EXACT []
synonym: "rpl5L" EXACT []

[Term]
id: sgd:S000002157
name: YBR089C-A
def: "High-mobility group \(HMG\) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog\, NHP6A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NHP6B" EXACT []
synonym: "YBR090C-A" EXACT []

[Term]
id: sgd:S000002158
name: YBR162W-A
def: "Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSY6" EXACT []

[Term]
id: sgd:S000002159
name: YDL001W
def: "Cytoplasmic protein required for sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMD1" EXACT []

[Term]
id: sgd:S000002160
name: YDL002C
def: "Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends\, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMO2" EXACT []
synonym: "NHP10" EXACT []

[Term]
id: sgd:S000002161
name: YDL003W
def: "Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCD1" EXACT []
synonym: "PDS3" EXACT []
synonym: "RHC21" EXACT []
synonym: "SCC1" EXACT []

[Term]
id: sgd:S000002162
name: YDL004W
def: "Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP16" EXACT []
synonym: "F1F0 ATP synthase subunit delta" EXACT []

[Term]
id: sgd:S000002163
name: YDL005C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED2" EXACT []

[Term]
id: sgd:S000002164
name: YDL006W
def: "Type 2C protein phosphatase \(PP2C\); dephosphorylates Hog1p\, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing\, mitochondrial inheritance\, and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH47" EXACT []
synonym: "KCS2" EXACT []
synonym: "PTC1" EXACT []
synonym: "TPD1" EXACT []
synonym: "type 2C protein phosphatase PTC1" EXACT []

[Term]
id: sgd:S000002165
name: YDL007W
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPT2" EXACT []
synonym: "YHS4" EXACT []
synonym: "YTA5" EXACT []
synonym: "proteasome regulatory particle base subunit RPT2" EXACT []

[Term]
id: sgd:S000002166
name: YDL008W
def: "Catalytic core subunit\, Anaphase-Promoting Complex/Cyclosome \(APC/C\); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC11" EXACT []
synonym: "anaphase promoting complex subunit 11" EXACT []

[Term]
id: sgd:S000002167
name: YDL009C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002168
name: YDL010W
def: "Cis-golgi localized monothiol glutaredoxin\, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog\, GRX7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX6" EXACT []
synonym: "glutathione-disulfide reductase GRX6" EXACT []

[Term]
id: sgd:S000002169
name: YDL011C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002170
name: YDL012C
def: "Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining \(NHEJ\) based on ydl012c htz1 double null phenotype; YDL012C has a paralog\, YBR016W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002171
name: YDL013W
def: "Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase \(STUbL\) complex; stimulated by SUMO-modified substrates; contains a RING domain and two SIM motifs; forms SUMO-dependent nuclear foci\, including DNA repair centers; associates with the centromere; null mutants are aneuploid\, have a metaphase delay\, and spindle defects including\: mispositioned spindles\, fish hook spindles\, and aberrant spindle kinetics; required for maintenance of genome integrity like human ortholog RNF4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEX3" EXACT []
synonym: "SLX5" EXACT []
synonym: "SUMO-targeted ubiquitin ligase complex subunit SLX5" EXACT []
synonym: "ULS2" EXACT []

[Term]
id: sgd:S000002172
name: YDL014W
def: "Histone glutamine methyltransferase\, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex\, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOT3" EXACT []
synonym: "NOP1" EXACT []
synonym: "rRNA methyltransferase NOP1" EXACT []

[Term]
id: sgd:S000002173
name: YDL015C
def: "Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER\, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSC13" EXACT []
synonym: "trans-2-enoyl-CoA reductase (NADPH) TSC13" EXACT []

[Term]
id: sgd:S000002174
name: YDL016C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C\, the catalytic subunit of a complex that regulates DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002175
name: YDL017W
def: "DDK \(Dbf4-dependent kinase\) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication\, meiotic DSB formation\, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC7" EXACT []
synonym: "LSD6" EXACT []
synonym: "SAS1" EXACT []
synonym: "serine/threonine protein kinase CDC7" EXACT []

[Term]
id: sgd:S000002176
name: YDL018C
def: "Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP3" EXACT []

[Term]
id: sgd:S000002177
name: YDL019C
def: "Member of an oxysterol-binding protein family with seven members; in S. cerevisiae\, family members have overlapping\, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH2 has a paralog\, SWH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSH2" EXACT []
synonym: "oxysterol-binding protein related protein OSH2" EXACT []

[Term]
id: sgd:S000002178
name: YDL020C
def: "Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN4" EXACT []
synonym: "SON1" EXACT []
synonym: "UFD5" EXACT []
synonym: "stress-regulated transcription factor RPN4" EXACT []

[Term]
id: sgd:S000002179
name: YDL021W
def: "Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog\, GPM3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPM2" EXACT []
synonym: "phosphoglycerate mutase family protein GPM2" EXACT []

[Term]
id: sgd:S000002180
name: YDL022W
def: "NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis\, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2\, dephosphorylation increases catalytic activity; GPD1 has a paralog\, GPD2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAR1" EXACT []
synonym: "GPD1" EXACT []
synonym: "HOR1" EXACT []
synonym: "OSG1" EXACT []
synonym: "OSR5" EXACT []
synonym: "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1" EXACT []

[Term]
id: sgd:S000002181
name: YDL023C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF4" EXACT []

[Term]
id: sgd:S000002182
name: YDL024C
def: "Protein of unknown function; involved in invasive and pseudohyphal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIA3" EXACT []
synonym: "putative acid phosphatase DIA3" EXACT []

[Term]
id: sgd:S000002183
name: YDL025C
def: "Putative protein kinase\, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors\, Cka2\, Gus1 and Arc1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTK1" EXACT []
synonym: "putative serine/threonine protein kinase RTK1" EXACT []

[Term]
id: sgd:S000002184
name: YDL026W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002185
name: YDL027C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002186
name: YDL028C
def: "Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body \(SPB\) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p\, Spc110p\, and Spc98p\, mitotic exit network protein Mob1p\, kinetochore protein Cnn1p\, and checkpoint protein Mad1p; substrate of APCC\(Cdh1\); similar to human Mps1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPS1" EXACT []
synonym: "PAC8" EXACT []
synonym: "RPK1" EXACT []
synonym: "serine/threonine/tyrosine protein kinase MPS1" EXACT []

[Term]
id: sgd:S000002187
name: YDL029W
def: "Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACT2" EXACT []
synonym: "ARP2" EXACT []
synonym: "actin-related protein 2" EXACT []

[Term]
id: sgd:S000002188
name: YDL030W
def: "Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP9" EXACT []

[Term]
id: sgd:S000002189
name: YDL031W
def: "Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP10" EXACT []

[Term]
id: sgd:S000002190
name: YDL032W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002191
name: YDL033C
def: "tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers \(MERRF\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTO2" EXACT []
synonym: "MTU1" EXACT []
synonym: "SLM3" EXACT []

[Term]
id: sgd:S000002192
name: YDL034W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002193
name: YDL035C
def: "Plasma membrane G protein coupled receptor \(GPCR\); interacts with the heterotrimeric G protein alpha subunit\, Gpa2p\, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPR1" EXACT []

[Term]
id: sgd:S000002194
name: YDL036C
def: "Mitochondrial tRNA\:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog\, RIB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS9" EXACT []
synonym: "pseudouridine synthase PUS9" EXACT []

[Term]
id: sgd:S000002195
name: YDL037C
def: "Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC1" EXACT []

[Term]
id: sgd:S000002197
name: YDL039C
def: "Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM7" EXACT []
synonym: "YDL038C" EXACT []
synonym: "pheromone-regulated protein PRM7" EXACT []

[Term]
id: sgd:S000002198
name: YDL040C
def: "Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p\, Ard1p\, and Nat5p; N-terminally acetylates many proteins\, which influences multiple processes such as the cell cycle\, heat-shock resistance\, mating\, sporulation\, and telomeric silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA1" EXACT []
synonym: "NAA15" EXACT []
synonym: "NAT1" EXACT []

[Term]
id: sgd:S000002199
name: YDL041W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002200
name: YDL042C
def: "Conserved NAD+ dependent histone deacetylase of the Sirtuin family; involved in regulation of lifespan; plays roles in silencing at HML\, HMR\, telomeres\, and the rDNA locus; negatively regulates initiation of DNA replication; functions as a regulator of autophagy like mammalian homolog SIRT1\, and also of mitophagy; SIR2 has a paralog\, HST1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAR1" EXACT []
synonym: "NAD-dependent histone deacetylase SIR2" EXACT []
synonym: "SIR2" EXACT []

[Term]
id: sgd:S000002201
name: YDL043C
def: "Subunit of the SF3a splicing factor complex; required for spliceosome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP11" EXACT []
synonym: "RNA11" EXACT []

[Term]
id: sgd:S000002202
name: YDL044C
def: "Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase \(Rpo41p\) and couples RNA processing and translation to transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTF2" EXACT []
synonym: "NAM1" EXACT []

[Term]
id: sgd:S000002203
name: YDL045C
def: "Flavin adenine dinucleotide \(FAD\) synthetase; performs the second step in synthesis of FAD from riboflavin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAD1" EXACT []
synonym: "FMN adenylyltransferase" EXACT []

[Term]
id: sgd:S000002204
name: YDL046W
def: "Functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPC2" EXACT []

[Term]
id: sgd:S000002205
name: YDL047W
def: "Type 2A-related serine-threonine phosphatase; functions in the G1/S transition of the mitotic cycle; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPH1" EXACT []
synonym: "SIT4" EXACT []
synonym: "type 2A-related serine/threonine-protein phosphatase SIT4" EXACT []

[Term]
id: sgd:S000002206
name: YDL048C
def: "Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p\, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog\, STP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STP4" EXACT []

[Term]
id: sgd:S000002207
name: YDL049C
def: "Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1\,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KNH1" EXACT []

[Term]
id: sgd:S000002208
name: YDL050C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002209
name: YDL051W
def: "RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La \(SS-B\) autoantigen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAH1" EXACT []
synonym: "LHP1" EXACT []
synonym: "YLA1" EXACT []

[Term]
id: sgd:S000002210
name: YDL052C
def: "1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid\, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-acylglycerol-3-phosphate O-acyltransferase SLC1" EXACT []
synonym: "SLC1" EXACT []

[Term]
id: sgd:S000002211
name: YDL053C
def: "Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 \(Pbp1p\) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBP4" EXACT []

[Term]
id: sgd:S000002212
name: YDL054C
def: "Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCH1" EXACT []

[Term]
id: sgd:S000002213
name: YDL055C
def: "GDP-mannose pyrophosphorylase \(mannose-1-phosphate guanyltransferase\); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPG1" EXACT []
synonym: "PSA1" EXACT []
synonym: "SRB1" EXACT []
synonym: "VIG9" EXACT []
synonym: "mannose-1-phosphate guanylyltransferase" EXACT []

[Term]
id: sgd:S000002214
name: YDL056W
def: "Transcription factor; involved in regulation of cell cycle progression from G1 to S phase\, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MBP1" EXACT []
synonym: "transcription factor MBP1" EXACT []

[Term]
id: sgd:S000002215
name: YDL057W
def: "Putative protein of unknown function; YDL057W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002216
name: YDL058W
def: "Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INT1" EXACT []
synonym: "USO1" EXACT []

[Term]
id: sgd:S000002217
name: YDL059C
def: "Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD59" EXACT []

[Term]
id: sgd:S000002218
name: YDL060W
def: "Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSR1" EXACT []

[Term]
id: sgd:S000002219
name: YDL061C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog\, RPS29A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS29B" EXACT []
synonym: "S14" EXACT []
synonym: "S29B" EXACT []
synonym: "S36B" EXACT []
synonym: "YS29" EXACT []
synonym: "YS29B" EXACT []
synonym: "ribosomal 40S subunit protein S29B" EXACT []

[Term]
id: sgd:S000002220
name: YDL062W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002221
name: YDL063C
def: "Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYO1" EXACT []

[Term]
id: sgd:S000002222
name: YDL064W
def: "SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome \(APCC\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 SUMO-conjugating protein UBC9" EXACT []
synonym: "UBC9" EXACT []

[Term]
id: sgd:S000002223
name: YDL065C
def: "Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins \(PMPs\) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS12" EXACT []
synonym: "PEX19" EXACT []

[Term]
id: sgd:S000002224
name: YDL066W
def: "Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDP1" EXACT []
synonym: "isocitrate dehydrogenase (NADP(+)) IDP1" EXACT []

[Term]
id: sgd:S000002225
name: YDL067C
def: "Subunit VIIa of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX9" EXACT []
synonym: "cytochrome c oxidase subunit VIIa" EXACT []

[Term]
id: sgd:S000002226
name: YDL068W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002227
name: YDL069C
def: "Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes\, acts on the COB mRNA 5'-untranslated leader" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBS1" EXACT []

[Term]
id: sgd:S000002228
name: YDL070W
def: "Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog\, BDF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BDF2" EXACT []

[Term]
id: sgd:S000002229
name: YDL071C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC1" EXACT []

[Term]
id: sgd:S000002230
name: YDL072C
def: "Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YET3" EXACT []

[Term]
id: sgd:S000002231
name: YDL073W
def: "Putative protein of unknown function; YDL073W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002232
name: YDL074C
def: "E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquinate histone H2B-K123\, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR\, transcription\, silencing\, and checkpoint control; interacts with RNA-binding protein Npl3p\, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRE1" EXACT []
synonym: "E3 ubiquitin-protein ligase BRE1" EXACT []

[Term]
id: sgd:S000002233
name: YDL075W
def: "Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31\, no bacterial homolog; RPL31A has a paralog\, RPL31B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L31A" EXACT []
synonym: "L31e" EXACT []
synonym: "L34A" EXACT []
synonym: "RPL31A" EXACT []
synonym: "RPL34" EXACT []
synonym: "YL28" EXACT []
synonym: "ribosomal 60S subunit protein L31A" EXACT []

[Term]
id: sgd:S000002234
name: YDL076C
def: "Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RXT3" EXACT []

[Term]
id: sgd:S000002235
name: YDL077C
def: "Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector\, interacting with both GTP- and GDP-bound conformations of Ypt7p\, facilitating tethering and promoting several membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CVT4" EXACT []
synonym: "VAM6" EXACT []
synonym: "VPL18" EXACT []
synonym: "VPL22" EXACT []
synonym: "VPS39" EXACT []

[Term]
id: sgd:S000002236
name: YDL078C
def: "Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDH3" EXACT []
synonym: "malate dehydrogenase MDH3" EXACT []

[Term]
id: sgd:S000002237
name: YDL079C
def: "Glycogen synthase kinase 3 \(GSK-3\) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog\, RIM11\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRK1" EXACT []
synonym: "putative serine/threonine protein kinase MRK1" EXACT []

[Term]
id: sgd:S000002238
name: YDL080C
def: "Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them\, but releases and de-activates them upon binding to thiamine pyrophosphate \(TPP\)\, the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KID1" EXACT []
synonym: "THI3" EXACT []
synonym: "branched-chain-2-oxoacid decarboxylase THI3" EXACT []

[Term]
id: sgd:S000002239
name: YDL081C
def: "Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free \(non-ribosomal\) P1 stimulates the phosphorylation of the eIF2 alpha subunit \(Sui2p\) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPLA1" EXACT []
synonym: "RPP1A" EXACT []
synonym: "ribosomal protein P1A" EXACT []

[Term]
id: sgd:S000002240
name: YDL082W
def: "Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13\, no bacterial homolog; RPL13A has a paralog\, RPL13B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13A" EXACT []
synonym: "L13e" EXACT []
synonym: "RPL13A" EXACT []
synonym: "ribosomal 60S subunit protein L13A" EXACT []

[Term]
id: sgd:S000002241
name: YDL083C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog\, RPS16A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS16B" EXACT []
synonym: "S16B" EXACT []
synonym: "S9" EXACT []
synonym: "ribosomal 40S subunit protein S16B" EXACT []
synonym: "rp61R" EXACT []

[Term]
id: sgd:S000002242
name: YDL084W
def: "Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase SUB2" EXACT []
synonym: "SUB2" EXACT []

[Term]
id: sgd:S000002243
name: YDL085W
def: "Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog\, NDE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NADH-ubiquinone reductase (H(+)-translocating) NDE2" EXACT []
synonym: "NDE2" EXACT []
synonym: "NDH2" EXACT []

[Term]
id: sgd:S000002244
name: YDL086W
def: "Putative carboxymethylenebutenolidase; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "carboxymethylenebutenolidase" EXACT []

[Term]
id: sgd:S000002245
name: YDL087C
def: "Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPE1" EXACT []
synonym: "EXM2" EXACT []
synonym: "LUC7" EXACT []

[Term]
id: sgd:S000002246
name: YDL088C
def: "FG-nucleoporin component of central core of nuclear pore complex \(NPC\); contributes directly to nucleocytoplasmic transport; induces membrane tubulation\, which may contribute to nuclear pore assembly; ASM4 has a paralog\, NUP53\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASM4" EXACT []
synonym: "FG-nucleoporin ASM4" EXACT []
synonym: "NUP59" EXACT []

[Term]
id: sgd:S000002247
name: YDL089W
def: "Protein of unknown function; interacts with Csm1p\, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery\, possible Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUR1" EXACT []

[Term]
id: sgd:S000002248
name: YDL090C
def: "Beta subunit of the CAAX farnesyltransferase \(FTase\); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPR1" EXACT []
synonym: "FUS8" EXACT []
synonym: "RAM1" EXACT []
synonym: "SCG2" EXACT []
synonym: "SGP2" EXACT []
synonym: "STE16" EXACT []
synonym: "protein farnesyltransferase" EXACT []

[Term]
id: sgd:S000002249
name: YDL091C
def: "Subunit of the DSC ubiquitin ligase complex; UBX \(ubiquitin regulatory X\) domain-containing protein that interacts with Cdc48p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBX3" EXACT []

[Term]
id: sgd:S000002250
name: YDL092W
def: "Signal recognition particle \(SRP\) subunit; interacts with the RNA component of SRP to form the Alu domain\, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP14" EXACT []

[Term]
id: sgd:S000002251
name: YDL093W
def: "Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p\, can instead interact with Pmt2p in some conditions; target for new antifungals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT5" EXACT []
synonym: "putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5" EXACT []

[Term]
id: sgd:S000002252
name: YDL094C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002253
name: YDL095W
def: "Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm\, carboxyl terminus faces ER lumen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT1" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase PMT1" EXACT []

[Term]
id: sgd:S000002254
name: YDL096C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI6" EXACT []

[Term]
id: sgd:S000002255
name: YDL097C
def: "Essential\, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog \(S9 protein\) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAS4" EXACT []
synonym: "RPN6" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN6" EXACT []

[Term]
id: sgd:S000002256
name: YDL098C
def: "Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNU23" EXACT []

[Term]
id: sgd:S000002257
name: YDL099W
def: "Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog\, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUG1" EXACT []

[Term]
id: sgd:S000002258
name: YDL100C
def: "Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of the GET complex\, which is involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored \(TA\) proteins into the ER membrane under non-stress conditions; has low-level ATPase activity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARR4" EXACT []
synonym: "GET3" EXACT []
synonym: "guanine nucleotide exchange factor GET3" EXACT []

[Term]
id: sgd:S000002259
name: YDL101C
def: "Cell-cycle checkpoint serine-threonine kinase; required for DNA damage-induced transcription of certain target genes\, phosphorylation of Rad55p and Sml1p\, and transient G2/M arrest after DNA damage; Mec1p and Dun1p function in same pathway to regulate both dNTP pools and telomere length; also regulates postreplicative DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUN1" EXACT []
synonym: "serine/threonine protein kinase DUN1" EXACT []

[Term]
id: sgd:S000002260
name: YDL102W
def: "Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis\, intragenic recombination\, repair of double strand DNA breaks\, and DNA replication during nucleotide excision repair \(NER\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC2" EXACT []
synonym: "DNA-directed DNA polymerase delta POL3" EXACT []
synonym: "HPR6" EXACT []
synonym: "POL3" EXACT []
synonym: "TEX1" EXACT []

[Term]
id: sgd:S000002261
name: YDL103C
def: "UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine \(UDP-GlcNAc\)\, which is important in cell wall biosynthesis\, protein N-glycosylation\, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QRI1" EXACT []
synonym: "UAP1" EXACT []
synonym: "UDP-N-acetylglucosamine diphosphorylase" EXACT []

[Term]
id: sgd:S000002262
name: YDL104C
def: "Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD\, both of which are also required for tRNA t6A modification; when directed to the cytoplasm\, complements the essential function of Kae1p in the KEOPS complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QRI7" EXACT []

[Term]
id: sgd:S000002263
name: YDL105W
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSE4" EXACT []
synonym: "QRI2" EXACT []

[Term]
id: sgd:S000002264
name: YDL106C
def: "Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAS2" EXACT []
synonym: "GRF10" EXACT []
synonym: "PHO2" EXACT []
synonym: "phoB" EXACT []

[Term]
id: sgd:S000002265
name: YDL107W
def: "Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p\, interacts genetically and physically with Cox18p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS2" EXACT []

[Term]
id: sgd:S000002266
name: YDL108W
def: "Serine/threonine protein kinase\, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain \(CTD\) at gene promoters; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIN28" EXACT []
synonym: "TFIIH complex serine/threonine-protein kinase subunit KIN28" EXACT []

[Term]
id: sgd:S000002267
name: YDL109C
def: "Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog\, ROG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative lipase" EXACT []

[Term]
id: sgd:S000002268
name: YDL110C
def: "ATPase dedicated chaperone that adapts proteasome assembly to stress; Tma17p is induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADC17" EXACT []
synonym: "TMA17" EXACT []

[Term]
id: sgd:S000002269
name: YDL111C
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p \(EXOSC7\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP42" EXACT []

[Term]
id: sgd:S000002270
name: YDL112W
def: "2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM3" EXACT []

[Term]
id: sgd:S000002271
name: YDL113C
def: "Sorting nexin family member; required for the cytoplasm-to-vacuole targeting \(Cvt\) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG20" EXACT []
synonym: "CVT20" EXACT []
synonym: "SNX42" EXACT []

[Term]
id: sgd:S000002272
name: YDL114W
def: "Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "short-chain dehydrogenase/reductase" EXACT []

[Term]
id: sgd:S000002273
name: YDL115C
def: "RNA polymerase II transport factor\, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IWR1" EXACT []

[Term]
id: sgd:S000002274
name: YDL116W
def: "Subunit of the Nup84p subcomplex of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery\, including double-strand break repair\, transcription and chromatin silencing; homologous to human NUP107" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP84" EXACT []

[Term]
id: sgd:S000002275
name: YDL117W
def: "SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYK3" EXACT []

[Term]
id: sgd:S000002276
name: YDL118W
def: "Dubious open reading frame\, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002277
name: YDL119C
def: "Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic\, non-tagged protein is detected in purified mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002278
name: YDL120W
def: "Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YFH1" EXACT []

[Term]
id: sgd:S000002279
name: YDL121C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002280
name: YDL122W
def: "Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP1" EXACT []

[Term]
id: sgd:S000002281
name: YDL123W
def: "Protein of unknown function; localized to the vacuolar outer membrane; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNA4" EXACT []

[Term]
id: sgd:S000002282
name: YDL124W
def: "NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides\, aliphatic alpha-keto esters\, and aromatic alpha-keto esters; member of the aldo-keto reductase \(AKR\) family; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "aldo-keto reductase superfamily protein" EXACT []

[Term]
id: sgd:S000002283
name: YDL125C
def: "Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p\, a CDK and TFIIK subunit\, and genetically with CAK1; member of the histidine triad \(HIT\) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HNT1" EXACT []

[Term]
id: sgd:S000002284
name: YDL126C
def: "AAA ATPase; subunit of polyubiquitin-selective segregase complex involved in ERAD\, cell wall integrity during heat stress\, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing\, in macroautophagy\, PMN\, RAD\, ribophagy\, homotypic ER membrane fusion\, disassembly of Met30p from SCF complex; functional ortholog of human p97/VCP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase CDC48" EXACT []
synonym: "CDC48" EXACT []

[Term]
id: sgd:S000002285
name: YDL127W
def: "Cyclin\, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1\,2-like subfamily\, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog\, PCL9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLN4" EXACT []
synonym: "PCL2" EXACT []
synonym: "cyclin PCL2" EXACT []

[Term]
id: sgd:S000002286
name: YDL128W
def: "Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers\, including the bovine Na+/Ca2+\,K+ antiporter" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUM1" EXACT []
synonym: "MNR1" EXACT []
synonym: "VCX1" EXACT []

[Term]
id: sgd:S000002287
name: YDL129W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002288
name: YDL130W
def: "Ribosomal protein P1 beta; component of the ribosomal stalk\, which is involved in interaction of translational elongation factors with ribosome; free \(non-ribosomal\) P1 stimulates the phosphorylation of the eIF2 alpha subunit \(Sui2p\) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Ax" EXACT []
synonym: "L44'" EXACT []
synonym: "P1B" EXACT []
synonym: "RPL44'" EXACT []
synonym: "RPLA3" EXACT []
synonym: "RPP1B" EXACT []
synonym: "YP1beta" EXACT []
synonym: "ribosomal protein P1B" EXACT []

[Term]
id: sgd:S000002289
name: YDL131W
def: "Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate\, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog\, LYS20\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS21" EXACT []
synonym: "homocitrate synthase LYS21" EXACT []

[Term]
id: sgd:S000002290
name: YDL132W
def: "Cullin; structural protein of SCF complexes \(which also contain Skp1p\, Cdc34p\, Hrt1p and an F-box protein\) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC53" EXACT []
synonym: "cullin CDC53" EXACT []

[Term]
id: sgd:S000002291
name: YDL133W
def: "Regulator of phospholipase D \(Spo14p\); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16\:0 platelet activating factor\, a lipid that accumulates intraneuronally in Alzheimer's patients" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF1" EXACT []

[Term]
id: sgd:S000002292
name: YDL134C
def: "Catalytic subunit of protein phosphatase 2A \(PP2A\); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog\, PPH22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPH21" EXACT []
synonym: "phosphoprotein phosphatase 2A catalytic subunit PPH21" EXACT []

[Term]
id: sgd:S000002293
name: YDL133C-A
def: "Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41\, no bacterial homolog; RPL41B has a paralog\, RPL41A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L41B" EXACT []
synonym: "L41e" EXACT []
synonym: "L47B" EXACT []
synonym: "RPL41B" EXACT []
synonym: "RPL47B" EXACT []
synonym: "YDL134C-A" EXACT []
synonym: "YL41" EXACT []
synonym: "ribosomal 60S subunit protein L41B" EXACT []

[Term]
id: sgd:S000002294
name: YDL135C
def: "Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDI1" EXACT []

[Term]
id: sgd:S000002295
name: YDL136W
def: "Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog\, RPL35A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L29" EXACT []
synonym: "L35B" EXACT []
synonym: "RPL35B" EXACT []
synonym: "SOS2" EXACT []
synonym: "ribosomal 60S subunit protein L35B" EXACT []

[Term]
id: sgd:S000002296
name: YDL137W
def: "ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog\, ARF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARF2" EXACT []
synonym: "Arf family GTPase ARF2" EXACT []

[Term]
id: sgd:S000002297
name: YDL138W
def: "Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog\, SNF3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGT2" EXACT []

[Term]
id: sgd:S000002298
name: YDL139C
def: "Nonhistone component of centromeric chromatin; binds to histone H3 variant\, Cse4p\, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCM3" EXACT []

[Term]
id: sgd:S000002299
name: YDL140C
def: "RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B220" EXACT []
synonym: "DNA-directed RNA polymerase II core subunit RPO21" EXACT []
synonym: "RPB1" EXACT []
synonym: "RPB220" EXACT []
synonym: "RPO21" EXACT []
synonym: "SUA8" EXACT []

[Term]
id: sgd:S000002300
name: YDL141W
def: "Biotin\:apoprotein ligase; covalently modifies proteins with the addition of biotin\, required for acetyl-CoA carboxylase \(Acc1p\) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACC2" EXACT []
synonym: "BPL1" EXACT []
synonym: "biotin--[acetyl-CoA-carboxylase] ligase BPL1" EXACT []

[Term]
id: sgd:S000002301
name: YDL142C
def: "Cardiolipin synthase; produces cardiolipin\, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS1" EXACT []
synonym: "CRD1" EXACT []
synonym: "cardiolipin synthase" EXACT []

[Term]
id: sgd:S000002302
name: YDL143W
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANC2" EXACT []
synonym: "CCT4" EXACT []
synonym: "TCP4" EXACT []

[Term]
id: sgd:S000002303
name: YDL144C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002304
name: YDL145C
def: "Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COP1" EXACT []
synonym: "RET1" EXACT []
synonym: "SEC33" EXACT []
synonym: "SOO1" EXACT []

[Term]
id: sgd:S000002305
name: YDL146W
def: "Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery\, cytoplasm\, bud\, and bud neck" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB17" EXACT []

[Term]
id: sgd:S000002306
name: YDL147W
def: "Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit\, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAS5" EXACT []
synonym: "RPN5" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN5" EXACT []

[Term]
id: sgd:S000002307
name: YDL148C
def: "Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex\, which is required for processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP14" EXACT []
synonym: "UTP2" EXACT []

[Term]
id: sgd:S000002308
name: YDL149W
def: "Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site \(PAS\) and other cytosolic punctate structures\, not found in autophagosomes; may be involved in membrane delivery to the PAS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG9" EXACT []
synonym: "ATG9" EXACT []
synonym: "AUT9" EXACT []
synonym: "CVT6" EXACT []
synonym: "CVT7" EXACT []
synonym: "autophagy protein ATG9" EXACT []

[Term]
id: sgd:S000002309
name: YDL150W
def: "RNA polymerase III subunit C53" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C53" EXACT []
synonym: "RPC4" EXACT []
synonym: "RPC53" EXACT []

[Term]
id: sgd:S000002310
name: YDL151C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD30" EXACT []

[Term]
id: sgd:S000002311
name: YDL152W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C\, a component of the small ribosomal subunit processosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002312
name: YDL153C
def: "Subunit of U3-containing Small Subunit \(SSU\) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAS10" EXACT []
synonym: "UTP3" EXACT []

[Term]
id: sgd:S000002313
name: YDL154W
def: "Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH5" EXACT []
synonym: "MutS family protein MSH5" EXACT []

[Term]
id: sgd:S000002314
name: YDL155W
def: "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2\, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog\, CLB4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB3" EXACT []
synonym: "CLB3" EXACT []

[Term]
id: sgd:S000002315
name: YDL156W
def: "DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains \(WD-40 repeat\); green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p\, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMR1" EXACT []

[Term]
id: sgd:S000002316
name: YDL157C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002317
name: YDL158C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002318
name: YDL159W
def: "Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE7" EXACT []
synonym: "mitogen-activated protein kinase kinase STE7" EXACT []

[Term]
id: sgd:S000002319
name: YDL160C
def: "Cytoplasmic DExD/H-box helicase\, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay\, interacts with both the decapping and deadenylase complexes\, role in translational repression\, mRNA decay\, and processing body dynamics; may have a role in mRNA export; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1\, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DExD/H-box ATP-dependent RNA helicase DHH1" EXACT []
synonym: "DHH1" EXACT []

[Term]
id: sgd:S000002320
name: YDL161W
def: "Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog\, ENT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENT1" EXACT []

[Term]
id: sgd:S000002321
name: YDL162C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W\, a verified gene involved in endocytosis and actin cortical patch assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002322
name: YDL163W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002323
name: YDL164C
def: "DNA ligase found in the nucleus and mitochondria; an essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair\, base excision repair\, and recombination\," []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC9" EXACT []
synonym: "DNA ligase (ATP) CDC9" EXACT []
synonym: "MMS8" EXACT []

[Term]
id: sgd:S000002324
name: YDL165W
def: "Component of the CCR4-NOT core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4-NOT core subunit CDC36" EXACT []
synonym: "CDC36" EXACT []
synonym: "DNA19" EXACT []
synonym: "NOT2" EXACT []

[Term]
id: sgd:S000002325
name: YDL166C
def: "Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p\, may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAP7" EXACT []

[Term]
id: sgd:S000002326
name: YDL167C
def: "Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRP1" EXACT []

[Term]
id: sgd:S000002327
name: YDL168W
def: "Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols\, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH5" EXACT []
synonym: "SFA1" EXACT []
synonym: "bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase" EXACT []

[Term]
id: sgd:S000002328
name: YDL169C
def: "Protein of unknown function; transcript accumulates in response to any combination of stress conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGX2" EXACT []

[Term]
id: sgd:S000002329
name: YDL170W
def: "Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA \(gamma-aminobutyrate\); zinc finger transcription factor of the Zn\(2\)-Cys\(6\) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1\, UGA2\, and UGA4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGA3" EXACT []

[Term]
id: sgd:S000002330
name: YDL171C
def: "NAD\(+\)-dependent glutamate synthase \(GOGAT\); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p\, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLT1" EXACT []
synonym: "glutamate synthase (NADH)" EXACT []

[Term]
id: sgd:S000002331
name: YDL172C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002332
name: YDL173W
def: "Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAR32" EXACT []

[Term]
id: sgd:S000002333
name: YDL174C
def: "D-lactate dehydrogenase; oxidizes D-lactate to pyruvate\, transcription is heme-dependent\, repressed by glucose\, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DLD1" EXACT []

[Term]
id: sgd:S000002334
name: YDL175C
def: "RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly\(A\) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog\, AIR1\, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIR2" EXACT []

[Term]
id: sgd:S000002335
name: YDL176W
def: "Protein of unknown function; predicted by computational methods to be involved in fructose-1\,6-bisphosphatase \(Fbp1p\) degradation; interacts with components of the GID complex; YDL176W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002336
name: YDL177C
def: "Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002337
name: YDL178W
def: "D-lactate dehydrogenase; located in the mitochondrial matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIP2" EXACT []
synonym: "DLD2" EXACT []

[Term]
id: sgd:S000002338
name: YDL179W
def: "Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase \(Cdk\)\, expressed in late M/early G1 phase\, activated by Swi5p; PCL9 has a paralog\, PCL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL9" EXACT []

[Term]
id: sgd:S000002339
name: YDL180W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002340
name: YDL181W
def: "Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog\, STF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INH1" EXACT []

[Term]
id: sgd:S000002341
name: YDL182W
def: "Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate\, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog\, LYS21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS20" EXACT []
synonym: "homocitrate synthase LYS20" EXACT []

[Term]
id: sgd:S000002342
name: YDL183C
def: "Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MKR1" EXACT []

[Term]
id: sgd:S000002343
name: YDL184C
def: "Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41\, no bacterial homolog; RPL41A has a paralog\, RPL41B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L41A" EXACT []
synonym: "L41e" EXACT []
synonym: "L47A" EXACT []
synonym: "RPL41A" EXACT []
synonym: "RPL47A" EXACT []
synonym: "YL41" EXACT []
synonym: "ribosomal 60S subunit protein L41A" EXACT []

[Term]
id: sgd:S000002344
name: YDL185W
def: "Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde \(PI-SceI\)\, which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase \(V-ATPase\) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS8" EXACT []
synonym: "H(+)-transporting V1 sector ATPase subunit A" EXACT []
synonym: "TFP1" EXACT []
synonym: "VMA1" EXACT []

[Term]
id: sgd:S000002345
name: YDL186W
def: "Putative protein of unknown function; YDL186W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002346
name: YDL187C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002347
name: YDL188C
def: "Catalytic subunit of protein phosphatase 2A \(PP2A\); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog\, PPH21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPH2" EXACT []
synonym: "PPH22" EXACT []
synonym: "phosphoprotein phosphatase 2A catalytic subunit PPH22" EXACT []

[Term]
id: sgd:S000002348
name: YDL189W
def: "Protein of unknown function; identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBS1" EXACT []

[Term]
id: sgd:S000002349
name: YDL190C
def: "Ubiquitin chain assembly factor \(E4\); cooperates with a ubiquitin-activating enzyme \(E1\)\, a ubiquitin-conjugating enzyme \(E2\)\, and a ubiquitin protein ligase \(E3\) to conjugate ubiquitin to substrates; also functions as an E3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UFD2" EXACT []
synonym: "ubiquitin-ubiquitin ligase UFD2" EXACT []

[Term]
id: sgd:S000002350
name: YDL191W
def: "Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog\, RPL35B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L29" EXACT []
synonym: "L35A" EXACT []
synonym: "RPL35A" EXACT []
synonym: "SOS1" EXACT []
synonym: "ribosomal 60S subunit protein L35A" EXACT []

[Term]
id: sgd:S000002351
name: YDL192W
def: "ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog\, ARF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARF1" EXACT []
synonym: "Arf family GTPase ARF1" EXACT []

[Term]
id: sgd:S000002352
name: YDL193W
def: "Putative prenyltransferase; required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUS1" EXACT []

[Term]
id: sgd:S000002353
name: YDL194W
def: "Plasma membrane low glucose sensor\, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog\, RGT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNF3" EXACT []

[Term]
id: sgd:S000002354
name: YDL195W
def: "Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC31" EXACT []
synonym: "WEB1" EXACT []

[Term]
id: sgd:S000002355
name: YDL196W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002356
name: YDL197C
def: "Anti-silencing protein; causes derepression of silent loci when overexpressed" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASF2" EXACT []

[Term]
id: sgd:S000002357
name: YDL198C
def: "Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GGC1" EXACT []
synonym: "SHM1" EXACT []
synonym: "YHM1" EXACT []

[Term]
id: sgd:S000002358
name: YDL199C
def: "Putative transporter; member of the sugar porter family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002359
name: YDL200C
def: "DNA repair methyltransferase \(6-O-methylguanine-DNA methylase\); involved in protection against DNA alkylation damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGMT" EXACT []
synonym: "MGT1" EXACT []

[Term]
id: sgd:S000002360
name: YDL201W
def: "Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N\(7\) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM8" EXACT []

[Term]
id: sgd:S000002361
name: YDL202W
def: "Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL11" EXACT []
synonym: "YmL11" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL11" EXACT []

[Term]
id: sgd:S000002362
name: YDL203C
def: "Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACK1" EXACT []

[Term]
id: sgd:S000002363
name: YDL204W
def: "Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p\, Yip3p\, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA \(reticulon-like A\) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog\, RTN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTN2" EXACT []

[Term]
id: sgd:S000002364
name: YDL205C
def: "Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane\, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p\, but not by levels of heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM3" EXACT []
synonym: "OLE2" EXACT []
synonym: "hydroxymethylbilane synthase" EXACT []

[Term]
id: sgd:S000002365
name: YDL206W
def: "Putative protein of unknown function; YDL206W is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002366
name: YDL207W
def: "Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate \(IP6\)\, functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRR3" EXACT []
synonym: "GLE1" EXACT []
synonym: "NLE2" EXACT []
synonym: "RSS1" EXACT []
synonym: "nucleoporin GLE1" EXACT []

[Term]
id: sgd:S000002367
name: YDL208W
def: "Protein related to mammalian high mobility group \(HMG\) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs\, which are involved in 18S rRNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NHP2" EXACT []
synonym: "snoRNA-binding protein NHP2" EXACT []

[Term]
id: sgd:S000002368
name: YDL209C
def: "Member of the NineTeen Complex \(NTC\); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC2" EXACT []
synonym: "NTC40" EXACT []

[Term]
id: sgd:S000002369
name: YDL210W
def: "GABA \(gamma-aminobutyrate\) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid \(ALA\); localized to the vacuolar membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGA4" EXACT []

[Term]
id: sgd:S000002370
name: YDL211C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole; YDL211C has a paralog\, TDA7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002371
name: YDL212W
def: "Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APF1" EXACT []
synonym: "SHR3" EXACT []

[Term]
id: sgd:S000002372
name: YDL213C
def: "rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif \(RRM\); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP6" EXACT []

[Term]
id: sgd:S000002373
name: YDL214C
def: "Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK\, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog\, NPR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRR2" EXACT []
synonym: "serine/threonine protein kinase PRR2" EXACT []

[Term]
id: sgd:S000002374
name: YDL215C
def: "NAD\(+\)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDH-B" EXACT []
synonym: "GDH2" EXACT []
synonym: "GDHB" EXACT []
synonym: "glutamate dehydrogenase (NAD(+))" EXACT []

[Term]
id: sgd:S000002375
name: YDL216C
def: "Catalytic subunit of the COP9 signalosome \(CSN\) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSN5" EXACT []
synonym: "JAB1" EXACT []
synonym: "RRI1" EXACT []

[Term]
id: sgd:S000002376
name: YDL217C
def: "Essential core component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM22" EXACT []

[Term]
id: sgd:S000002377
name: YDL218W
def: "Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002378
name: YDL219W
def: "D-Tyr-tRNA\(Tyr\) deacylase; functions in protein translation\, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DTD1" EXACT []

[Term]
id: sgd:S000002379
name: YDL220C
def: "Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase\, telomere end protection\, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes\, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC13" EXACT []
synonym: "EST4" EXACT []
synonym: "telomere-binding protein CDC13" EXACT []

[Term]
id: sgd:S000002380
name: YDL221W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002381
name: YDL222C
def: "Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog\, YNL194C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP45" EXACT []

[Term]
id: sgd:S000002382
name: YDL223C
def: "Shmoo tip protein\, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation\, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog\, YNL195C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HBT1" EXACT []

[Term]
id: sgd:S000002383
name: YDL224C
def: "Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog\, WHI3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WHI4" EXACT []

[Term]
id: sgd:S000002384
name: YDL225W
def: "Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEP7" EXACT []
synonym: "SHS1" EXACT []
synonym: "septin SHS1" EXACT []

[Term]
id: sgd:S000002385
name: YDL226C
def: "ADP-ribosylation factor GTPase activating protein \(ARF GAP\); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog\, SPS18\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCS1" EXACT []

[Term]
id: sgd:S000002386
name: YDL227C
def: "Site-specific endonuclease; required for gene conversion at the MAT locus \(homothallic switching\) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p\, Swi5p\, and Ash1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HO" EXACT []

[Term]
id: sgd:S000002387
name: YDL228C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002388
name: YDL229W
def: "Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog\, SSB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family ATPase SSB1" EXACT []
synonym: "SSB1" EXACT []
synonym: "YG101" EXACT []

[Term]
id: sgd:S000002389
name: YDL230W
def: "Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo\, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTP1" EXACT []
synonym: "tyrosine protein phosphatase PTP1" EXACT []

[Term]
id: sgd:S000002390
name: YDL231C
def: "Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A\, a drug which is known to affect intracellular transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRE4" EXACT []

[Term]
id: sgd:S000002391
name: YDL232W
def: "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OST4" EXACT []

[Term]
id: sgd:S000002392
name: YDL233W
def: "Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; YDL233W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFG1" EXACT []

[Term]
id: sgd:S000002393
name: YDL234C
def: "GTPase-activating protein for yeast Rab family members; members include Ypt7p \(most effective\)\, Ypt1p\, Ypt31p\, and Ypt32p \(in vitro\); involved in vesicle mediated protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP7" EXACT []

[Term]
id: sgd:S000002394
name: YDL235C
def: "Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPD1" EXACT []

[Term]
id: sgd:S000002395
name: YDL236W
def: "Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO13" EXACT []

[Term]
id: sgd:S000002396
name: YDL237W
def: "Putative protein of unknown function; required for respiratory growth; YDL237W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM6" EXACT []
synonym: "LRC1" EXACT []

[Term]
id: sgd:S000002397
name: YDL238C
def: "Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUD1" EXACT []
synonym: "guanine deaminase" EXACT []

[Term]
id: sgd:S000002398
name: YDL239C
def: "Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog\, CNM67\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADY3" EXACT []

[Term]
id: sgd:S000002399
name: YDL240W
def: "GTPase-activating protein \(GAP\); contains Rho1p-specific GAP activity\, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1\,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 \(LIM\) domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LRG1" EXACT []

[Term]
id: sgd:S000002400
name: YDL241W
def: "Putative protein of unknown function; YDL241W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002401
name: YDL242W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002402
name: YDL243C
def: "Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs \(AAD3 + AAD15\, AAD6/AAD16 + AAD4\, AAD10 + AAD14\) whose two genes are more related to one another than to other members of the family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAD4" EXACT []

[Term]
id: sgd:S000002403
name: YDL244W
def: "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5\, THI11\, THI12\, and THI13; hydroxymethylpyrimidine is also known as HMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI13" EXACT []

[Term]
id: sgd:S000002404
name: YDL245C
def: "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT15" EXACT []
synonym: "hexose transporter HXT15" EXACT []

[Term]
id: sgd:S000002405
name: YDL246C
def: "Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L-iditol 2-dehydrogenase SOR2" EXACT []
synonym: "SOR2" EXACT []

[Term]
id: sgd:S000002406
name: YDL247W
def: "Alpha-glucoside permease; transports maltose\, maltotriose\, alpha-methylglucoside\, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPH2" EXACT []

[Term]
id: sgd:S000002407
name: YDL248W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS7" EXACT []

[Term]
id: sgd:S000002408
name: YDR001C
def: "Neutral trehalase\, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; inhibited by Dcs1p; NTH1 has a paralog\, NTH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTH1" EXACT []
synonym: "alpha" EXACT []
synonym: "alpha-trehalase NTH1" EXACT []

[Term]
id: sgd:S000002409
name: YDR002W
def: "Ran GTPase binding protein; involved in nuclear protein import and RNA export\, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST20" EXACT []
synonym: "HTN1" EXACT []
synonym: "SFO1" EXACT []
synonym: "STP52" EXACT []
synonym: "YRB1" EXACT []

[Term]
id: sgd:S000002410
name: YDR003W
def: "Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway\, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog\, RCR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCR2" EXACT []
synonym: "SSH5" EXACT []

[Term]
id: sgd:S000002411
name: YDR004W
def: "Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD57" EXACT []
synonym: "putative DNA-dependent ATPase RAD57" EXACT []

[Term]
id: sgd:S000002412
name: YDR005C
def: "Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay \(RTD\) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation\, mediated by TORC1\, protein kinase A\, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAF1" EXACT []
synonym: "RNA polymerase III-inhibiting protein MAF1" EXACT []

[Term]
id: sgd:S000002413
name: YDR006C
def: "Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOK1" EXACT []

[Term]
id: sgd:S000002414
name: YDR007W
def: "Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004\, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP \(TAA\) to serine \(TCA\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRP1" EXACT []
synonym: "phosphoribosylanthranilate isomerase TRP1" EXACT []

[Term]
id: sgd:S000002415
name: YDR008C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps TRP1/YDR007W on opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002416
name: YDR009W
def: "Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog\, GAL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL3" EXACT []
synonym: "transcriptional regulator GAL3" EXACT []

[Term]
id: sgd:S000002417
name: YDR010C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002418
name: YDR011W
def: "Plasma membrane ATP-binding cassette \(ABC\) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette transporter SNQ2" EXACT []
synonym: "SNQ2" EXACT []

[Term]
id: sgd:S000002419
name: YDR012W
def: "Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog\, RPL4A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L2B" EXACT []
synonym: "L4" EXACT []
synonym: "L4B" EXACT []
synonym: "RPL4B" EXACT []
synonym: "YL2" EXACT []
synonym: "ribosomal 60S subunit protein L4B" EXACT []
synonym: "rp2" EXACT []

[Term]
id: sgd:S000002420
name: YDR013W
def: "Subunit of the GINS complex \(Sld5p\, Psf1p\, Psf2p\, Psf3p\); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC101" EXACT []
synonym: "PSF1" EXACT []

[Term]
id: sgd:S000002421
name: YDR014W
def: "Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD61" EXACT []
synonym: "WPL1" EXACT []

[Term]
id: sgd:S000002422
name: YDR015C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002423
name: YDR016C
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAD1" EXACT []

[Term]
id: sgd:S000002424
name: YDR017C
def: "Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis\, stress response\, and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KCS1" EXACT []
synonym: "inositol polyphosphate kinase KCS1" EXACT []

[Term]
id: sgd:S000002425
name: YDR018C
def: "Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog\, CST26\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative acyltransferase" EXACT []

[Term]
id: sgd:S000002426
name: YDR019C
def: "T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5\,10-methylene-THF; expression is regulated by levels of levels of 5\,10-methylene-THF in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCV1" EXACT []
synonym: "GSD1" EXACT []
synonym: "glycine decarboxylase subunit T" EXACT []

[Term]
id: sgd:S000002427
name: YDR020C
def: "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAS2" EXACT []
synonym: "RRT3" EXACT []
synonym: "putative uridine kinase DAS2" EXACT []

[Term]
id: sgd:S000002428
name: YDR021W
def: "Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase FAL1" EXACT []
synonym: "FAL1" EXACT []

[Term]
id: sgd:S000002429
name: YDR022C
def: "Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG31" EXACT []
synonym: "CIS1" EXACT []

[Term]
id: sgd:S000002430
name: YDR023W
def: "Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA\(Ser\)\, displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate\, interacts with peroxin Pex21p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SES1" EXACT []
synonym: "SerRS" EXACT []
synonym: "serine--tRNA ligase SES1" EXACT []

[Term]
id: sgd:S000002431
name: YDR024W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV1" EXACT []

[Term]
id: sgd:S000002432
name: YDR025W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog\, RPS11B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS11A" EXACT []
synonym: "S11A" EXACT []
synonym: "S17" EXACT []
synonym: "S18A" EXACT []
synonym: "YS12" EXACT []
synonym: "ribosomal 40S subunit protein S11A" EXACT []
synonym: "rp41A" EXACT []

[Term]
id: sgd:S000002433
name: YDR026C
def: "RNA polymerase I termination factor; binds to rDNA terminator element\, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1\, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits\, Sir2p and Net1p; may interact with ribosomes\, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog\, REB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSI1" EXACT []

[Term]
id: sgd:S000002434
name: YDR027C
def: "Component of the GARP \(Golgi-associated retrograde protein\) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi\, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CGP1" EXACT []
synonym: "LUV1" EXACT []
synonym: "TCS3" EXACT []
synonym: "VPS54" EXACT []

[Term]
id: sgd:S000002435
name: YDR028C
def: "Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog\, REG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEX2" EXACT []
synonym: "PZF240" EXACT []
synonym: "REG1" EXACT []
synonym: "SPP43" EXACT []
synonym: "SRN1" EXACT []
synonym: "protein phosphatase regulator REG1" EXACT []

[Term]
id: sgd:S000002436
name: YDR029W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002437
name: YDR030C
def: "Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD28" EXACT []

[Term]
id: sgd:S000002438
name: YDR031W
def: "Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIC14" EXACT []
synonym: "MIX14" EXACT []

[Term]
id: sgd:S000002439
name: YDR032C
def: "Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog\, RFS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PST2" EXACT []

[Term]
id: sgd:S000002440
name: YDR033W
def: "Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic\, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRH1" EXACT []

[Term]
id: sgd:S000002441
name: YDR034C
def: "Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS14" EXACT []

[Term]
id: sgd:S000002442
name: YDR035W
def: "3-deoxy-D-arabino-heptulosonate-7-phosphate \(DAHP\) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-deoxy-7-phosphoheptulonate synthase ARO3" EXACT []
synonym: "ARO3" EXACT []

[Term]
id: sgd:S000002443
name: YDR036C
def: "3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EHD3" EXACT []
synonym: "MRP5" EXACT []

[Term]
id: sgd:S000002444
name: YDR037W
def: "Lysyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD5" EXACT []
synonym: "KRS1" EXACT []
synonym: "lysine--tRNA ligase KRS1" EXACT []

[Term]
id: sgd:S000002445
name: YDR038C
def: "Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENA5" EXACT []
synonym: "putative Na(+)-exporting P-type ATPase ENA5" EXACT []

[Term]
id: sgd:S000002446
name: YDR039C
def: "P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENA2" EXACT []
synonym: "Na(+)-exporting P-type ATPase ENA2" EXACT []

[Term]
id: sgd:S000002447
name: YDR040C
def: "P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENA1" EXACT []
synonym: "HOR6" EXACT []
synonym: "Na(+)/Li(+)-exporting P-type ATPase ENA1" EXACT []
synonym: "PMR2" EXACT []

[Term]
id: sgd:S000002448
name: YDR041W
def: "Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability\, unlike most other mitoribosomal proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM10" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM10" EXACT []

[Term]
id: sgd:S000002449
name: YDR042C
def: "Putative protein of unknown function; expression is increased in ssu72-ts69 mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002450
name: YDR043C
def: "Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRG1" EXACT []
synonym: "transcriptional regulator NRG1" EXACT []

[Term]
id: sgd:S000002451
name: YDR044W
def: "Coproporphyrinogen III oxidase; an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme \(via Rox1p and Hap1p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM13" EXACT []
synonym: "coproporphyrinogen oxidase" EXACT []

[Term]
id: sgd:S000002452
name: YDR045C
def: "RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C11" EXACT []
synonym: "DNA-directed RNA polymerase III core subunit RPC11" EXACT []
synonym: "RPC11" EXACT []

[Term]
id: sgd:S000002453
name: YDR046C
def: "Amino acid permease; involved in uptake of cysteine\, leucine\, isoleucine and valine; BAP3 has a paralog\, BAP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAP3" EXACT []
synonym: "PAP1" EXACT []
synonym: "amino acid transporter BAP3" EXACT []

[Term]
id: sgd:S000002454
name: YDR047W
def: "Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM12" EXACT []
synonym: "HEM6" EXACT []
synonym: "uroporphyrinogen decarboxylase HEM12" EXACT []

[Term]
id: sgd:S000002455
name: YDR048C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF VMS1/YDR049W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002456
name: YDR049W
def: "Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization\, with Cdc48p\, during normal growth\, and contributes to ER-associated degradation \(ERAD\) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation \(MAD\); conserved in C. elegans and humans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VMS1" EXACT []

[Term]
id: sgd:S000002457
name: YDR050C
def: "Triose phosphate isomerase\, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p\, Gcr1p\, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP \(phosphoenolpyruvate\) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPI1" EXACT []
synonym: "triose-phosphate isomerase TPI1" EXACT []

[Term]
id: sgd:S000002458
name: YDR051C
def: "Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DET1" EXACT []
synonym: "acid phosphatase DET1" EXACT []

[Term]
id: sgd:S000002459
name: YDR052C
def: "Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBF4" EXACT []
synonym: "DNA52" EXACT []
synonym: "LSD7" EXACT []
synonym: "protein serine/threonine kinase activating protein DBF4" EXACT []

[Term]
id: sgd:S000002460
name: YDR053W
def: "Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002461
name: YDR054C
def: "Ubiquitin-conjugating enzyme \(E2\); catalytic subunit of SCF ubiquitin-protein ligase complex \(together with Skp1p\, Rbx1p\, Cdc53p\, and an F-box protein\) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC34" EXACT []
synonym: "DNA6" EXACT []
synonym: "SCF E2 ubiquitin-protein ligase catalytic subunit CDC34" EXACT []
synonym: "UBC3" EXACT []

[Term]
id: sgd:S000002462
name: YDR055W
def: "Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway\, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog\, ECM33\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPF2" EXACT []
synonym: "PST1" EXACT []

[Term]
id: sgd:S000002463
name: YDR056C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002464
name: YDR057W
def: "ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1\,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOS9" EXACT []

[Term]
id: sgd:S000002465
name: YDR058C
def: "Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TGL2" EXACT []

[Term]
id: sgd:S000002466
name: YDR059C
def: "Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived\, abnormal\, or excess proteins\, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog\, UBC4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-conjugating protein UBC5" EXACT []
synonym: "UBC5" EXACT []

[Term]
id: sgd:S000002467
name: YDR060W
def: "Constituent of 66S pre-ribosomal particles; required for large \(60S\) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK21" EXACT []
synonym: "NOC1" EXACT []

[Term]
id: sgd:S000002468
name: YDR061W
def: "Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002469
name: YDR062W
def: "Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis\, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCB2" EXACT []
synonym: "SCS1" EXACT []
synonym: "TSC1" EXACT []
synonym: "serine C-palmitoyltransferase LCB2" EXACT []

[Term]
id: sgd:S000002470
name: YDR063W
def: "Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor \(GMF\); null mutant displays elevated mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM7" EXACT []
synonym: "GMF" EXACT []
synonym: "GMF1" EXACT []

[Term]
id: sgd:S000002471
name: YDR064W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS13" EXACT []
synonym: "RPS13B" EXACT []
synonym: "RPS13C" EXACT []
synonym: "S13" EXACT []
synonym: "S15" EXACT []
synonym: "S27a" EXACT []
synonym: "YS15" EXACT []
synonym: "ribosomal 40S subunit protein S13" EXACT []

[Term]
id: sgd:S000002472
name: YDR065W
def: "Protein of unknown function; required for vacuolar acidification and mitochondrial genome maintenance; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRG1" EXACT []

[Term]
id: sgd:S000002473
name: YDR066C
def: "Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog\, RTR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTR2" EXACT []

[Term]
id: sgd:S000002474
name: YDR067C
def: "Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA6" EXACT []

[Term]
id: sgd:S000002475
name: YDR068W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOS2" EXACT []

[Term]
id: sgd:S000002476
name: YDR069C
def: "Ubiquitin hydrolase; deubiquitinates intralumenal vesicle \(ILVs\) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates\, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog\, UBP5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA4" EXACT []
synonym: "DOS1" EXACT []
synonym: "MUT4" EXACT []
synonym: "NPI2" EXACT []
synonym: "SSV7" EXACT []
synonym: "UBP4" EXACT []

[Term]
id: sgd:S000002477
name: YDR070C
def: "Protein of unknown function; may be involved in responding to conditions of stress; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP16" EXACT []

[Term]
id: sgd:S000002478
name: YDR071C
def: "Polyamine acetyltransferase; acetylates polyamines \(e.g. putrescine\, spermidine\, spermine\) and also aralkylamines \(e.g. tryptamine\, phenylethylamine\); may be involved in transcription and/or DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAA1" EXACT []

[Term]
id: sgd:S000002479
name: YDR072C
def: "Inositolphosphotransferase; involved in synthesis of mannose-\(inositol-P\)2-ceramide \(M\(IP\)2C\)\, the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPT1" EXACT []
synonym: "KTI6" EXACT []
synonym: "MIC2" EXACT []
synonym: "SYR4" EXACT []
synonym: "inositolphosphotransferase" EXACT []

[Term]
id: sgd:S000002480
name: YDR073W
def: "Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNF11" EXACT []

[Term]
id: sgd:S000002481
name: YDR074W
def: "Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOG2" EXACT []
synonym: "PFK3" EXACT []
synonym: "TPS2" EXACT []
synonym: "trehalose-phosphatase TPS2" EXACT []

[Term]
id: sgd:S000002482
name: YDR075W
def: "Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex\, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint\, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining \(NHEJ\) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPH3" EXACT []
synonym: "phosphoprotein phosphatase PP4 catalytic subunit PPH3" EXACT []

[Term]
id: sgd:S000002483
name: YDR076W
def: "Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD55" EXACT []
synonym: "putative DNA-dependent ATPase RAD55" EXACT []

[Term]
id: sgd:S000002484
name: YDR077W
def: "Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes\, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog\, SPI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SED1" EXACT []

[Term]
id: sgd:S000002485
name: YDR078C
def: "Component of Shu complex \(aka PCSS complex\); Shu complex also includes Psy3\, Csm2\, Shu1\, and promotes error-free DNA repair\, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHU2" EXACT []

[Term]
id: sgd:S000002486
name: YDR079W
def: "Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII\, VIIa\, and VIII \(Cox7p\, Cox9p\, and Cox8p\) but not with the holoenzyme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET100" EXACT []

[Term]
id: sgd:S000002487
name: YDR080W
def: "Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector\, interacting specifically with the GTP-bound conformation of Ypt7p\, facilitating tethering\, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CVT8" EXACT []
synonym: "FET2" EXACT []
synonym: "SVL2" EXACT []
synonym: "VAM2" EXACT []
synonym: "VPL20" EXACT []
synonym: "VPS41" EXACT []

[Term]
id: sgd:S000002488
name: YDR081C
def: "Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase \(PDC1 and PDC5\) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDC2" EXACT []

[Term]
id: sgd:S000002489
name: YDR082W
def: "Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis\, and in a regulatory step required for telomere capping; similar to human Stn1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STN1" EXACT []

[Term]
id: sgd:S000002490
name: YDR083W
def: "Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine \(m1A\) of the large subunit \(LSU\) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP8" EXACT []

[Term]
id: sgd:S000002491
name: YDR084C
def: "Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TVP23" EXACT []

[Term]
id: sgd:S000002492
name: YDR085C
def: "Protein required for pheromone-induced projection \(shmoo\) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog\, YER158C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFR1" EXACT []

[Term]
id: sgd:S000002493
name: YDR086C
def: "Subunit of the Sec61p translocation complex \(Sec61p-Sss1p-Sbh1p\); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane\, and of the Ssh1p complex \(Ssh1p-Sbh2p-Sss1p\); interacts with Ost4p and Wbp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSS1" EXACT []
synonym: "translocon subunit SSS1" EXACT []

[Term]
id: sgd:S000002494
name: YDR087C
def: "Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP1" EXACT []

[Term]
id: sgd:S000002495
name: YDR088C
def: "RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLT17" EXACT []
synonym: "SLU7" EXACT []

[Term]
id: sgd:S000002496
name: YDR089W
def: "Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain\, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002497
name: YDR090C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002498
name: YDR091C
def: "Essential Fe-S protein; required for ribosome biogenesis\, translation initiation/termination; facilitates binding of multifactor complex \(MFC\) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes\, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters\, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RLI1" EXACT []

[Term]
id: sgd:S000002499
name: YDR092W
def: "E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2  ubiquitin-conjugating protein UBC13" EXACT []
synonym: "UBC13" EXACT []

[Term]
id: sgd:S000002500
name: YDR093W
def: "Aminophospholipid translocase \(flippase\); type 4 P-type ATPase; involved in phospholipid translocation\, contributing to endocytosis\, protein transport\, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog\, DNF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNF2" EXACT []
synonym: "aminophospholipid-translocating P4-type ATPase DNF2" EXACT []

[Term]
id: sgd:S000002501
name: YDR094W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002502
name: YDR095C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002503
name: YDR096W
def: "Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact\, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog\, RPH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIS1" EXACT []
synonym: "histone demethylase GIS1" EXACT []

[Term]
id: sgd:S000002504
name: YDR097C
def: "Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH6" EXACT []
synonym: "PMS3" EXACT []
synonym: "PMS6" EXACT []
synonym: "mismatch repair ATPase MSH6" EXACT []

[Term]
id: sgd:S000002505
name: YDR098C
def: "Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p\, binds to Aft1p in iron-replete conditions\, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated\, but rather Met36; GRX3 has a paralog\, GRX4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX3" EXACT []
synonym: "monothiol glutaredoxin GRX3" EXACT []

[Term]
id: sgd:S000002506
name: YDR099W
def: "14-3-3 protein\, minor isoform; controls proteome at post-transcriptional level\, binds proteins and DNA\, involved in regulation of many processes including exocytosis\, vesicle transport\, Ras/MAPK signaling\, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; abundance relative to Bmh1p increases during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "14-3-3 family protein BMH2" EXACT []
synonym: "BMH2" EXACT []
synonym: "SCD3" EXACT []

[Term]
id: sgd:S000002507
name: YDR100W
def: "Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TVP15" EXACT []

[Term]
id: sgd:S000002508
name: YDR101C
def: "Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARX1" EXACT []

[Term]
id: sgd:S000002509
name: YDR102C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; homozygous diploid deletion strain exhibits high budding index" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002510
name: YDR103W
def: "Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components \(Ste11p\, Ste7p and Fus3p\) under basal conditions; Gbeta-gamma \(Ste4p-Ste18p\)-dependent docking at the plasma membrane and binding of PI\(4\,5\)P2 by the PH domain relieves autoinhibition\, resulting in pheromone-dependent pathway activation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMD3" EXACT []
synonym: "NUL3" EXACT []
synonym: "STE5" EXACT []

[Term]
id: sgd:S000002511
name: YDR104C
def: "Meiosis-specific protein required for spore wall formation; localizes to prospore membrane \(PSM\) and is required for PSM closure during sporulation; mediates PSM size; interacts with Spo1p and Vps13p and recruits Vps13p to the PSM during sporulation; mutants exhibit reduction in PSM PtdIns-phosphate pools; dispensable for both nuclear divisions during meiosis; contains two PH domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO71" EXACT []

[Term]
id: sgd:S000002512
name: YDR105C
def: "Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p\, a protein involved in multidrug resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMS1" EXACT []

[Term]
id: sgd:S000002513
name: YDR106W
def: "Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP10" EXACT []

[Term]
id: sgd:S000002514
name: YDR107C
def: "Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; TMN2 has a paralog\, EMP70\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMN2" EXACT []

[Term]
id: sgd:S000002515
name: YDR108W
def: "Component of transport protein particle \(TRAPP\) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSG1" EXACT []
synonym: "MUM1" EXACT []
synonym: "TRS85" EXACT []

[Term]
id: sgd:S000002516
name: YDR109C
def: "Putative kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative phosphotransferase" EXACT []

[Term]
id: sgd:S000002517
name: YDR110W
def: "Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking\, recombinational hotspot activity\, condensin recruitment to replication fork barrier \(RFB\)\, and rDNA repeat segregation; related to retroviral integrases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOB1" EXACT []
synonym: "HRM1" EXACT []
synonym: "replication fork barrier binding protein FOB1" EXACT []

[Term]
id: sgd:S000002518
name: YDR111C
def: "Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog\, ALT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALT2" EXACT []
synonym: "alanine transaminase ALT2" EXACT []

[Term]
id: sgd:S000002519
name: YDR112W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ALT2/YDR111C; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC2" EXACT []

[Term]
id: sgd:S000002520
name: YDR113C
def: "Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit\, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDS1" EXACT []
synonym: "securin" EXACT []

[Term]
id: sgd:S000002521
name: YDR114C
def: "Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002522
name: YDR115W
def: "Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth\, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative mitochondrial 54S ribosomal protein" EXACT []

[Term]
id: sgd:S000002523
name: YDR116C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL1" EXACT []
synonym: "mitochondrial 54S ribosomal protein MRPL1" EXACT []

[Term]
id: sgd:S000002524
name: YDR117C
def: "Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein\, eIF2D\, has been shown to possess translation initiation factor activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF64" EXACT []
synonym: "TMA64" EXACT []

[Term]
id: sgd:S000002525
name: YDR118W
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; component of the platform domain of the APC/C\, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC4" EXACT []
synonym: "anaphase promoting complex subunit 4" EXACT []

[Term]
id: sgd:S000002526
name: YDR119W
def: "Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VBA4" EXACT []

[Term]
id: sgd:S000002527
name: YDR120C
def: "tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2\,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner membrane in WT\, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body \(SPB\) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM1" EXACT []

[Term]
id: sgd:S000002528
name: YDR121W
def: "Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA\, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPB4" EXACT []

[Term]
id: sgd:S000002529
name: YDR122W
def: "Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog\, KIN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIN1" EXACT []
synonym: "serine/threonine protein kinase KIN1" EXACT []

[Term]
id: sgd:S000002530
name: YDR123C
def: "Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements \(ICREs\)\, required for derepression of phospholipid biosynthetic genes in response to inositol depletion; involved in diauxic shift" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIE1" EXACT []
synonym: "INO2" EXACT []
synonym: "SCS1" EXACT []

[Term]
id: sgd:S000002531
name: YDR124W
def: "Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002532
name: YDR125C
def: "Protein of unknown function; ECM18 has a paralog\, ICT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM18" EXACT []
synonym: "alpha/beta hydrolase family protein" EXACT []

[Term]
id: sgd:S000002533
name: YDR126W
def: "Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p\, Syn8p\, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich \(DHHC-CRD\) domain; may have a role in vacuole fusion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSL10" EXACT []
synonym: "SWF1" EXACT []

[Term]
id: sgd:S000002534
name: YDR127W
def: "Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate\, which is a precursor to aromatic amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO1" EXACT []
synonym: "pentafunctional protein ARO1p" EXACT []

[Term]
id: sgd:S000002535
name: YDR128W
def: "Subunit of the SEA \(Seh1-associated\) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC5" EXACT []
synonym: "SEA3" EXACT []

[Term]
id: sgd:S000002536
name: YDR129C
def: "Fimbrin\, actin-bundling protein; cooperates with Scp1p \(calponin/transgelin\) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABP67" EXACT []
synonym: "SAC6" EXACT []
synonym: "fimbrin" EXACT []

[Term]
id: sgd:S000002537
name: YDR130C
def: "Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIN1" EXACT []

[Term]
id: sgd:S000002538
name: YDR131C
def: "F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002539
name: YDR132C
def: "Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog\, YLR108C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002540
name: YDR133C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps YDR134C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002542
name: YDR135C
def: "Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals \(Cd\, Hg\, As\); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin\, selenodigluthatione\, oxidized glutathione; similar to human cystic fibrosis protein CFTR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette glutathione S-conjugate transporter YCF1" EXACT []
synonym: "YCF1" EXACT []

[Term]
id: sgd:S000002543
name: YDR136C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS61" EXACT []

[Term]
id: sgd:S000002544
name: YDR137W
def: "Subunit of a Golgi membrane exchange factor \(Ric1p-Rgp1p\); this complex catalyzes nucleotide exchange on Ypt6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGP1" EXACT []

[Term]
id: sgd:S000002545
name: YDR138W
def: "Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export\, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPR1" EXACT []
synonym: "TRF1" EXACT []

[Term]
id: sgd:S000002546
name: YDR139C
def: "Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation \(neddylation\) substrates include the cullins Cdc53p\, Rtt101p\, and Cul3p; activated by Ula1p and Uba3p \(E1 enzyme pair\); conjugation mediated by Ubc12p \(E2 enzyme\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEDD8 family protein RUB1" EXACT []
synonym: "RUB1" EXACT []

[Term]
id: sgd:S000002547
name: YDR140W
def: "S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p \(eRF1\) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTQ2" EXACT []

[Term]
id: sgd:S000002548
name: YDR141C
def: "Golgi-localized\, leucine-zipper domain containing protein; involved in endosome to Golgi transport\, organization of the ER\, establishing cell polarity\, and morphogenesis; detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOP1" EXACT []

[Term]
id: sgd:S000002549
name: YDR142C
def: "Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal \(PTS2\); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata \(RCDP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS7" EXACT []
synonym: "PEB1" EXACT []
synonym: "PEX7" EXACT []

[Term]
id: sgd:S000002550
name: YDR143C
def: "Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility\, suggesting that San1p evolved to target highly aggregation-prone proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAN1" EXACT []
synonym: "ubiquitin-protein ligase SAN1" EXACT []

[Term]
id: sgd:S000002551
name: YDR144C
def: "GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog\, YPS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MKC7" EXACT []
synonym: "YPS2" EXACT []

[Term]
id: sgd:S000002552
name: YDR145W
def: "Subunit \(61/68 kDa\) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification\, similar to histone H2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF12" EXACT []
synonym: "TAF61" EXACT []
synonym: "TAF68" EXACT []
synonym: "TafII61" EXACT []
synonym: "TafII68" EXACT []

[Term]
id: sgd:S000002553
name: YDR146C
def: "Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog\, ACE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding transcription factor SWI5" EXACT []
synonym: "SWI5" EXACT []

[Term]
id: sgd:S000002554
name: YDR147W
def: "Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity\, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog\, CKI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EKI1" EXACT []
synonym: "bifunctional choline kinase/ethanolamine kinase EKI1" EXACT []

[Term]
id: sgd:S000002555
name: YDR148C
def: "Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex\, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KGD2" EXACT []
synonym: "alpha-ketoglutarate dehydrogenase KGD2" EXACT []

[Term]
id: sgd:S000002556
name: YDR149C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene NUM1/YDR150W; null mutation blocks anaerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002557
name: YDR150W
def: "Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor \(MECA\); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and motochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUM1" EXACT []
synonym: "PAC12" EXACT []

[Term]
id: sgd:S000002558
name: YDR151C
def: "Member of the CCCH zinc finger family; similar to mammalian Tis11 protein\, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; CTH1 has a paralog\, TIS11\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTH1" EXACT []
synonym: "putative mRNA-binding protein CTH1" EXACT []

[Term]
id: sgd:S000002559
name: YDR152W
def: "Highly-acidic RWD domain-containing protein of unknown function; cytoplasmic; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIR2" EXACT []

[Term]
id: sgd:S000002560
name: YDR153C
def: "Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p\, clathrin adaptor complex AP-1\, and clathrin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENT5" EXACT []

[Term]
id: sgd:S000002561
name: YDR154C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002562
name: YDR155C
def: "Cytoplasmic peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPH1" EXACT []
synonym: "CPR1" EXACT []
synonym: "CYP1" EXACT []
synonym: "peptidylprolyl isomerase CPR1" EXACT []

[Term]
id: sgd:S000002563
name: YDR156W
def: "RNA polymerase I subunit A14" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A14" EXACT []
synonym: "DNA-directed RNA polymerase I subunit RPA14" EXACT []
synonym: "RPA14" EXACT []

[Term]
id: sgd:S000002564
name: YDR157W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002565
name: YDR158W
def: "Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOM2" EXACT []
synonym: "THR2" EXACT []
synonym: "aspartate-semialdehyde dehydrogenase" EXACT []

[Term]
id: sgd:S000002566
name: YDR159W
def: "mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex \(Sac3p-Thp1p-Sus1p-Cdc31p\) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein \(GANP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEP1" EXACT []
synonym: "SAC3" EXACT []

[Term]
id: sgd:S000002567
name: YDR160W
def: "Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p\, Ptr3p\, and Ssy5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAA1" EXACT []
synonym: "SHR10" EXACT []
synonym: "SSY1" EXACT []

[Term]
id: sgd:S000002568
name: YDR161W
def: "Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation \(ERAD\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002569
name: YDR162C
def: "Protein involved in the HOG \(high osmolarity glycerol\) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm\, contains an SH3 domain and a Ptc1p binding domain \(PBM\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NBP2" EXACT []

[Term]
id: sgd:S000002570
name: YDR163W
def: "Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC15" EXACT []

[Term]
id: sgd:S000002571
name: YDR164C
def: "Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion \(bud neck and bud tip\) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC1" EXACT []

[Term]
id: sgd:S000002572
name: YDR165W
def: "Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N\(7\) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM82" EXACT []

[Term]
id: sgd:S000002573
name: YDR166C
def: "Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC5" EXACT []

[Term]
id: sgd:S000002574
name: YDR167W
def: "Subunit \(145 kDa\) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF10" EXACT []
synonym: "TAF23" EXACT []
synonym: "TAF25" EXACT []
synonym: "TafII25" EXACT []

[Term]
id: sgd:S000002575
name: YDR168W
def: "Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC37" EXACT []
synonym: "SMO1" EXACT []

[Term]
id: sgd:S000002576
name: YDR169C
def: "Ribosomal RNA processing element \(RRPE\)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells\, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB3" EXACT []

[Term]
id: sgd:S000002577
name: YDR170C
def: "Guanine nucleotide exchange factor \(GEF\) for ADP ribosylation factors; involved in proliferation of the Golgi\, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor SEC7" EXACT []
synonym: "SEC7" EXACT []

[Term]
id: sgd:S000002578
name: YDR171W
def: "Small heat shock protein \(sHSP\) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP42" EXACT []

[Term]
id: sgd:S000002579
name: YDR172W
def: "Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the \[PSI\(+\)\] prion that modifies cellular fitness\, alters translational fidelity by affecting reading frame selection\, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of \[PSI\(+\)\]" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GST1" EXACT []
synonym: "PNM2" EXACT []
synonym: "SAL3" EXACT []
synonym: "SUF12" EXACT []
synonym: "SUP2" EXACT []
synonym: "SUP35" EXACT []
synonym: "SUP36" EXACT []
synonym: "[PSI(+)]" EXACT []
synonym: "[PSI]" EXACT []
synonym: "eRF3" EXACT []
synonym: "translation termination factor GTPase eRF3" EXACT []

[Term]
id: sgd:S000002580
name: YDR173C
def: "Inositol polyphosphate multikinase \(IPMK\); sequentially phosphorylates Ins\(1\,4\,5\)P3 to form Ins\(1\,3\,4\,5\,6\)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-\, phosphate-\, and nitrogen-responsive genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG82" EXACT []
synonym: "ARGR3" EXACT []
synonym: "ARGRIII" EXACT []
synonym: "IPK2" EXACT []
synonym: "inositol polyphosphate multikinase" EXACT []

[Term]
id: sgd:S000002581
name: YDR174W
def: "Chromatin associated high mobility group \(HMG\) family member; involved in compacting\, bending\, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p\, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMO1" EXACT []
synonym: "HSM2" EXACT []

[Term]
id: sgd:S000002582
name: YDR175C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM24" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM24" EXACT []

[Term]
id: sgd:S000002583
name: YDR176W
def: "Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex\, the SAGA complex\, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADA3" EXACT []
synonym: "NGG1" EXACT []
synonym: "SWI7" EXACT []
synonym: "histone acetyltransferase NGG1" EXACT []

[Term]
id: sgd:S000002584
name: YDR177W
def: "Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex \(APC\); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation \(ERAD\); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex \(APC\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-conjugating protein UBC1" EXACT []
synonym: "UBC1" EXACT []

[Term]
id: sgd:S000002585
name: YDR178W
def: "Membrane anchor subunit of succinate dehydrogenase \(SDH\); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D \(SDHD\)\, which is implicated in paraganglioma" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACN18" EXACT []
synonym: "SDH4" EXACT []
synonym: "succinate dehydrogenase membrane anchor subunit SDH4" EXACT []

[Term]
id: sgd:S000002586
name: YDR179C
def: "Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation\, or removal of the ubiquitin-like protein Rub1p from Cdc53p \(cullin\); involved in adaptation to pheromone signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSN9" EXACT []

[Term]
id: sgd:S000002587
name: YDR179W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002588
name: YDR180W
def: "Subunit of cohesin loading factor \(Scc2p-Scc4p\); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCC2" EXACT []

[Term]
id: sgd:S000002589
name: YDR181C
def: "Subunit of the SAS complex \(Sas2p\, Sas4p\, Sas5p\); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAS4" EXACT []

[Term]
id: sgd:S000002590
name: YDR182W
def: "Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC1" EXACT []
synonym: "DSC1" EXACT []
synonym: "DSR1" EXACT []
synonym: "ESP2" EXACT []
synonym: "putative lipid phosphatase CDC1" EXACT []

[Term]
id: sgd:S000002591
name: YDR183W
def: "Protein that interacts with CCT \(chaperonin containing TCP-1\) complex; has a role in actin and tubulin folding; has weak similarity to phosducins\, which are G-protein regulators" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLP1" EXACT []

[Term]
id: sgd:S000002592
name: YDR184C
def: "Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATC1" EXACT []
synonym: "LIC4" EXACT []

[Term]
id: sgd:S000002593
name: YDR185C
def: "Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog\, UPS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEP2" EXACT []
synonym: "UPS3" EXACT []

[Term]
id: sgd:S000002594
name: YDR186C
def: "Putative protein of unknown function; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002595
name: YDR187C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified\, essential ORF CCT6/YDR188W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002596
name: YDR188W
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCT6" EXACT []
synonym: "HTR3" EXACT []
synonym: "TCP20" EXACT []
synonym: "TCP6" EXACT []

[Term]
id: sgd:S000002597
name: YDR189W
def: "Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM \(Sec1/Munc-18\) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLY1" EXACT []

[Term]
id: sgd:S000002598
name: YDR190C
def: "ATP-dependent DNA helicase\, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex\, the Swr1 complex\, and the R2TP complex \(Rvb1-Rvb2-Tah1-Pih1\); involved in multiple processes such as chromatin remodeling\, box C/D snoRNP assembly\, and RNA polymerase II assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RVB1" EXACT []
synonym: "RuvB family ATP-dependent DNA helicase pontin" EXACT []
synonym: "TIH1" EXACT []
synonym: "TIP49" EXACT []
synonym: "TIP49A" EXACT []

[Term]
id: sgd:S000002599
name: YDR191W
def: "Member of the Sir2 family of NAD\(+\)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres\, cell cycle progression\, radiation resistance\, genomic stability and short-chain fatty acid metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HST4" EXACT []

[Term]
id: sgd:S000002600
name: YDR192C
def: "FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex \(NPC\) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP42" EXACT []
synonym: "NUP42" EXACT []
synonym: "RIP1" EXACT []
synonym: "UIP1" EXACT []

[Term]
id: sgd:S000002601
name: YDR193W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002602
name: YDR194C
def: "Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS116" EXACT []

[Term]
id: sgd:S000002603
name: YDR195W
def: "RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation\, and in snoRNA maturation; part of holo-CPF subcomplex APT\, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REF2" EXACT []

[Term]
id: sgd:S000002604
name: YDR196C
def: "Subunit of the CoA-Synthesizing Protein Complex \(CoA-SPC\); subunits of this complex are\: Cab2p\, Cab3p\, Cab4p\, Cab5p\, Sis2p and Vhs3p; probable dephospho-CoA kinase \(DPCK\) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE \(encoding DPCK\); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAB5" EXACT []
synonym: "putative dephospho-CoA kinase" EXACT []

[Term]
id: sgd:S000002605
name: YDR197W
def: "Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes\, acts on the COB mRNA 5'-untranslated leader" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP7" EXACT []
synonym: "CBS2" EXACT []

[Term]
id: sgd:S000002606
name: YDR198C
def: "Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKM2" EXACT []

[Term]
id: sgd:S000002607
name: YDR199W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64/YDR200C; computationally predicted to have thiol-disulfide oxidoreductase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002608
name: YDR200C
def: "Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog\, FAR10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR9" EXACT []
synonym: "VPS64" EXACT []

[Term]
id: sgd:S000002609
name: YDR201W
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC19" EXACT []

[Term]
id: sgd:S000002610
name: YDR202C
def: "Subunit of RAVE complex \(Rav1p\, Rav2p\, Skp1p\); the RAVE complex associates with the V1 domain of the vacuolar membrane \(H+\)-ATPase \(V-ATPase\) and promotes assembly and reassembly of the holoenzyme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAV2" EXACT []

[Term]
id: sgd:S000002611
name: YDR203W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF RAV2/YDR202C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002612
name: YDR204W
def: "Protein with a role in ubiquinone \(Coenzyme Q\) biosynthesis; possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ4" EXACT []

[Term]
id: sgd:S000002613
name: YDR205W
def: "Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSC2" EXACT []
synonym: "metal cation transporter MSC2" EXACT []

[Term]
id: sgd:S000002614
name: YDR206W
def: "Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog\, EST1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EBS1" EXACT []

[Term]
id: sgd:S000002615
name: YDR207C
def: "Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence\, couples metabolic responses to nutritional cues with initiation and progression of meiosis\, forms complex with Ime1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAR80" EXACT []
synonym: "DNA-binding transcriptional regulator UME6" EXACT []
synonym: "NIM2" EXACT []
synonym: "RIM16" EXACT []
synonym: "UME6" EXACT []

[Term]
id: sgd:S000002616
name: YDR208W
def: "Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-phosphatidylinositol-4-phosphate 5-kinase" EXACT []
synonym: "MSS4" EXACT []

[Term]
id: sgd:S000002617
name: YDR209C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002618
name: YDR210W
def: "Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002619
name: YDR211W
def: "Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD6" EXACT []

[Term]
id: sgd:S000002620
name: YDR212W
def: "Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCT1" EXACT []
synonym: "TCP1" EXACT []
synonym: "chaperonin-containing T-complex alpha subunit TCP1" EXACT []

[Term]
id: sgd:S000002621
name: YDR213W
def: "Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog\, ECM22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOX4" EXACT []
synonym: "UPC2" EXACT []

[Term]
id: sgd:S000002622
name: YDR214W
def: "Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AHA1" EXACT []

[Term]
id: sgd:S000002623
name: YDR215C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002624
name: YDR216W
def: "Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2\, of peroxisomal protein genes\, and of genes required for ethanol\, glycerol\, and fatty acid utilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADR1" EXACT []
synonym: "DNA-binding transcription factor ADR1" EXACT []

[Term]
id: sgd:S000002625
name: YDR217C
def: "DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S\, intra-S\, and G2/M\, plays a role in postreplication repair \(PRR\) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain \(CAD\) is phosphorylated at multiple sites by Cdc28p/Clb2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD9" EXACT []
synonym: "chromatin-binding protein RAD9" EXACT []

[Term]
id: sgd:S000002626
name: YDR218C
def: "Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPR28" EXACT []
synonym: "septin SPR28" EXACT []

[Term]
id: sgd:S000002627
name: YDR219C
def: "Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFB1" EXACT []

[Term]
id: sgd:S000002628
name: YDR220C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002629
name: YDR221W
def: "Glucosidase II beta subunit\, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTB1" EXACT []

[Term]
id: sgd:S000002630
name: YDR222W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog\, YLR225C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002631
name: YDR223W
def: "Transcriptional corepressor; involved in repression of ribosomal protein \(RP\) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog\, IFH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRF1" EXACT []

[Term]
id: sgd:S000002632
name: YDR224C
def: "Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication\, transcriptional activation\, meiotic DSB formation and H3 methylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTB1" EXACT []
synonym: "SPT12" EXACT []
synonym: "histone H2B" EXACT []

[Term]
id: sgd:S000002633
name: YDR225W
def: "Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes \(see also HTA2\); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H2A1" EXACT []
synonym: "HTA1" EXACT []
synonym: "SPT11" EXACT []
synonym: "histone H2A" EXACT []

[Term]
id: sgd:S000002634
name: YDR226W
def: "Adenylate kinase\, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADK1" EXACT []
synonym: "AKY1" EXACT []
synonym: "AKY2" EXACT []
synonym: "adenylate kinase ADK1" EXACT []

[Term]
id: sgd:S000002635
name: YDR227W
def: "SIR protein involved in assembly of silent chromatin domains; silent information regulator \(SIR\) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASD1" EXACT []
synonym: "SIR4" EXACT []
synonym: "STE9" EXACT []
synonym: "UTH2" EXACT []
synonym: "chromatin-silencing protein SIR4" EXACT []

[Term]
id: sgd:S000002636
name: YDR228C
def: "mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA \(CF IA\)\, involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II \(Rpo21p\); required for gene looping; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCF11" EXACT []

[Term]
id: sgd:S000002637
name: YDR229W
def: "Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa\, localizes to the rim of the vacuole as cells approach stationary phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IVY1" EXACT []

[Term]
id: sgd:S000002638
name: YDR230W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20/YDR231C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002639
name: YDR231C
def: "Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX20" EXACT []

[Term]
id: sgd:S000002640
name: YDR232W
def: "5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "5-aminolevulinate synthase" EXACT []
synonym: "CYD1" EXACT []
synonym: "HEM1" EXACT []
synonym: "OLE3" EXACT []

[Term]
id: sgd:S000002641
name: YDR233C
def: "Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p\, Yip3p\, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog\, RTN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTN1" EXACT []

[Term]
id: sgd:S000002642
name: YDR234W
def: "Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate\, which is a step in the lysine biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS3" EXACT []
synonym: "LYS4" EXACT []
synonym: "homoaconitate hydratase LYS4" EXACT []

[Term]
id: sgd:S000002643
name: YDR235W
def: "U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUD16" EXACT []
synonym: "PRP42" EXACT []
synonym: "SNU65" EXACT []

[Term]
id: sgd:S000002644
name: YDR236C
def: "Riboflavin kinase\, produces riboflavin monophosphate \(FMN\); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMN1" EXACT []
synonym: "riboflavin kinase" EXACT []

[Term]
id: sgd:S000002645
name: YDR237W
def: "Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7\, which are two different modified forms of the same protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL7" EXACT []
synonym: "YmL5" EXACT []
synonym: "YmL7" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL7/YmL5" EXACT []

[Term]
id: sgd:S000002646
name: YDR238C
def: "Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein \(beta-COP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC26" EXACT []

[Term]
id: sgd:S000002647
name: YDR239C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002648
name: YDR240C
def: "Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific\, no metazoan counterpart; interacts with mRNA in commitment complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUD10" EXACT []
synonym: "SNU56" EXACT []

[Term]
id: sgd:S000002649
name: YDR241W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD26" EXACT []

[Term]
id: sgd:S000002650
name: YDR242W
def: "Putative amidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMD2" EXACT []

[Term]
id: sgd:S000002651
name: YDR243C
def: "RNA helicase in the DEAD-box family; involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP28" EXACT []

[Term]
id: sgd:S000002652
name: YDR244W
def: "Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence \(PTS1\) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS10" EXACT []
synonym: "PEX5" EXACT []

[Term]
id: sgd:S000002653
name: YDR245W
def: "Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p\, Mnn9p\, Mnn11p\, and Hoc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BED1" EXACT []
synonym: "MNN10" EXACT []
synonym: "REC41" EXACT []
synonym: "SLC2" EXACT []

[Term]
id: sgd:S000002654
name: YDR246W
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\); human homolog is TRAPPC4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS23" EXACT []

[Term]
id: sgd:S000002655
name: YDR247W
def: "Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant\, suggesting a role in G1/S phase progression; VHS1 has a paralog\, SKS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHS1" EXACT []
synonym: "putative serine/threonine protein kinase VHS1" EXACT []

[Term]
id: sgd:S000002656
name: YDR248C
def: "Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor\, PAF1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "gluconokinase" EXACT []

[Term]
id: sgd:S000002657
name: YDR249C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002658
name: YDR250C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002659
name: YDR251W
def: "Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A\, inhibits growth\, and induces a filamentous phenotype; PAM1 has a paralog\, SVL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAM1" EXACT []

[Term]
id: sgd:S000002660
name: YDR252W
def: "Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog\, EGD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTT1" EXACT []
synonym: "CCR4-NOT core subunit BTT1" EXACT []

[Term]
id: sgd:S000002661
name: YDR253C
def: "Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog\, MET31\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET32" EXACT []

[Term]
id: sgd:S000002662
name: YDR254W
def: "Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p\, Ctf3p\, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-N and fission yeast mis15" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL4" EXACT []
synonym: "CTF17" EXACT []
synonym: "MCM17" EXACT []

[Term]
id: sgd:S000002663
name: YDR255C
def: "Component of GID Complex that confers ubiquitin ligase \(U3\) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1\,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID2" EXACT []
synonym: "RMD5" EXACT []
synonym: "ubiquitin-protein ligase RMD5" EXACT []

[Term]
id: sgd:S000002664
name: YDR256C
def: "Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase \(Pox1p\) during fatty acid beta-oxidation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTA1" EXACT []
synonym: "catalase A" EXACT []

[Term]
id: sgd:S000002665
name: YDR257C
def: "Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp \(lysine 55\); nuclear SET-domain containing protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKM4" EXACT []
synonym: "RMS1" EXACT []
synonym: "SET7" EXACT []

[Term]
id: sgd:S000002666
name: YDR258C
def: "Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP78" EXACT []
synonym: "chaperone ATPase HSP78" EXACT []

[Term]
id: sgd:S000002667
name: YDR259C
def: "Basic leucine zipper \(bZIP\) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog\, CIN5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL7" EXACT []
synonym: "YAP6" EXACT []

[Term]
id: sgd:S000002668
name: YDR260C
def: "Subunit of the anaphase-promoting complex \(APC\); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC13" EXACT []
synonym: "SWM1" EXACT []

[Term]
id: sgd:S000002669
name: YDR261C
def: "Exo-1\,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol \(GPI\) anchor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EXG2" EXACT []

[Term]
id: sgd:S000002670
name: YDR262W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002671
name: YDR263C
def: "Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome\, induced by exposure to mutagens\, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog\, EXO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIN3" EXACT []
synonym: "DIN7" EXACT []
synonym: "exodeoxyribonuclease DIN7" EXACT []

[Term]
id: sgd:S000002672
name: YDR264C
def: "Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog\, AKR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AKR1" EXACT []

[Term]
id: sgd:S000002673
name: YDR265W
def: "Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS4" EXACT []
synonym: "PEX10" EXACT []
synonym: "ubiquitin-protein ligase peroxin 10" EXACT []

[Term]
id: sgd:S000002674
name: YDR266C
def: "RING finger ubiquitin ligase \(E3\); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea \(HU\); green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase HEL2" EXACT []
synonym: "HEL2" EXACT []

[Term]
id: sgd:S000002675
name: YDR267C
def: "Component of cytosolic iron-sulfur protein assembly \(CIA\) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis\, DNA replication and repair\, transcription\, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIA1" EXACT []

[Term]
id: sgd:S000002676
name: YDR268W
def: "Mitochondrial tryptophanyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSW1" EXACT []
synonym: "tryptophan--tRNA ligase MSW1" EXACT []

[Term]
id: sgd:S000002677
name: YDR269C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002678
name: YDR270W
def: "Cu\(+2\)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model \(+\)RNA virus replication by regulating copper metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCC2" EXACT []
synonym: "Cu(2+)-transporting P-type ATPase CCC2" EXACT []

[Term]
id: sgd:S000002679
name: YDR271C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002680
name: YDR272W
def: "Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog\, GLO4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLO2" EXACT []
synonym: "hydroxyacylglutathione hydrolase GLO2" EXACT []

[Term]
id: sgd:S000002681
name: YDR273W
def: "Meiosis-specific component of the spindle pole body; part of the leading edge protein \(LEP\) coat\, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; DON1 has a paralog\, CUE5\, that arose from the whole genome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DON1" EXACT []

[Term]
id: sgd:S000002682
name: YDR274C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002683
name: YDR275W
def: "Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; BSC2 has a paralog\, IRC23\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC2" EXACT []

[Term]
id: sgd:S000002684
name: YDR276C
def: "Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMP3" EXACT []
synonym: "SNA1" EXACT []

[Term]
id: sgd:S000002685
name: YDR277C
def: "Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p\, triggering Mth1p degradation; MTH1 has a paralog\, STD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BPC1" EXACT []
synonym: "DGT1" EXACT []
synonym: "HTR1" EXACT []
synonym: "MTH1" EXACT []

[Term]
id: sgd:S000002686
name: YDR278C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002687
name: YDR279W
def: "Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNH202" EXACT []
synonym: "Rnh2B" EXACT []

[Term]
id: sgd:S000002688
name: YDR280W
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p \(PM/SCL-75\, EXOSC9\); protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP45" EXACT []
synonym: "exosome non-catalytic core subunit RRP45" EXACT []

[Term]
id: sgd:S000002689
name: YDR281C
def: "Protein of unknown function; expression is regulated by phosphate levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM6" EXACT []

[Term]
id: sgd:S000002690
name: YDR282C
def: "Mitochondrial inner membrane protein of unknown function; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1\, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002691
name: YDR283C
def: "Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 \(Sui2p\) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAS1" EXACT []
synonym: "AAS102" EXACT []
synonym: "GCN2" EXACT []
synonym: "NDR2" EXACT []
synonym: "serine/threonine-protein kinase GCN2" EXACT []

[Term]
id: sgd:S000002692
name: YDR284C
def: "Diacylglycerol pyrophosphate \(DGPP\) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase\, dephosphorylates DGPP to phosphatidate \(PA\) and Pi\, then PA to diacylglycerol; involved in lipid signaling and cell metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPP1" EXACT []
synonym: "ZRG1" EXACT []
synonym: "bifunctional diacylglycerol diphosphate phospatase/phosphatidate phosphatase" EXACT []

[Term]
id: sgd:S000002693
name: YDR285W
def: "Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZIP1" EXACT []

[Term]
id: sgd:S000002694
name: YDR286C
def: "Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002695
name: YDR287W
def: "Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INM2" EXACT []
synonym: "inositol monophosphate 1-phosphatase INM2" EXACT []

[Term]
id: sgd:S000002696
name: YDR288W
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSE3" EXACT []

[Term]
id: sgd:S000002697
name: YDR289C
def: "Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain \(carboxy-terminal domain interacting domain\); also involved in regulation of Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTT103" EXACT []

[Term]
id: sgd:S000002698
name: YDR290W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWS1" EXACT []

[Term]
id: sgd:S000002699
name: YDR291W
def: "3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome \(RTS\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRQ1" EXACT []

[Term]
id: sgd:S000002700
name: YDR292C
def: "Signal recognition particle \(SRP\) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit\, Srp102p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP101" EXACT []
synonym: "Signal recognition particle receptor subunit alpha" EXACT []

[Term]
id: sgd:S000002701
name: YDR293C
def: "Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLA1" EXACT []
synonym: "MCS1" EXACT []
synonym: "RLT1" EXACT []
synonym: "SRK1" EXACT []
synonym: "SSD1" EXACT []
synonym: "mRNA-binding translational repressor SSD1" EXACT []

[Term]
id: sgd:S000002702
name: YDR294C
def: "Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates \(LCBPs\)\, degrades phosphorylated long chain bases\, prefers C16 dihydrosphingosine-l-phosphate as a substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BST1" EXACT []
synonym: "DPL1" EXACT []
synonym: "sphinganine-1-phosphate aldolase DPL1" EXACT []

[Term]
id: sgd:S000002703
name: YDR295C
def: "Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDA2" EXACT []
synonym: "PLO2" EXACT []

[Term]
id: sgd:S000002704
name: YDR296W
def: "Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHR1" EXACT []
synonym: "XTC1" EXACT []

[Term]
id: sgd:S000002705
name: YDR297W
def: "Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUR2" EXACT []
synonym: "SYR2" EXACT []
synonym: "sphingosine hydroxylase" EXACT []

[Term]
id: sgd:S000002706
name: YDR298C
def: "Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP \(oligomycin sensitivity-conferring protein\); phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP5" EXACT []
synonym: "F1F0 ATP synthase subunit 5" EXACT []
synonym: "OSC1" EXACT []

[Term]
id: sgd:S000002707
name: YDR299W
def: "Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BFR2" EXACT []

[Term]
id: sgd:S000002708
name: YDR300C
def: "Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog\, YHR033W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRO1" EXACT []
synonym: "glutamate 5-kinase" EXACT []

[Term]
id: sgd:S000002709
name: YDR301W
def: "RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly\(A\) site recognition and required for both pre-mRNA cleavage and polyadenylation\, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CFT1" EXACT []
synonym: "YHH1" EXACT []

[Term]
id: sgd:S000002710
name: YDR302W
def: "ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol \(GPI\) intermediate; human PIG-Fp is a functional homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI11" EXACT []

[Term]
id: sgd:S000002711
name: YDR303C
def: "Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog\, RSC30\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC3" EXACT []

[Term]
id: sgd:S000002712
name: YDR304C
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog\, CPR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR5" EXACT []
synonym: "CYP5" EXACT []
synonym: "peptidylprolyl isomerase family protein CPR5" EXACT []

[Term]
id: sgd:S000002713
name: YDR305C
def: "Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad \(HIT\) superfamily of nucleotide-binding proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APH1" EXACT []
synonym: "HNT2" EXACT []

[Term]
id: sgd:S000002714
name: YDR306C
def: "F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat \(LRR\) domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002715
name: YDR307W
def: "Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT7" EXACT []

[Term]
id: sgd:S000002716
name: YDR308C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED21" EXACT []
synonym: "SRB7" EXACT []
synonym: "SSX1" EXACT []

[Term]
id: sgd:S000002717
name: YDR309C
def: "Redundant rho-like GTPase Cdc42p effector; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding \(CRIB\) domain and with PI\(4\,5\)P2 via a polybasic region; GIC2 has a paralog\, GIC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIC2" EXACT []

[Term]
id: sgd:S000002718
name: YDR310C
def: "Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance\, chromatin silencing; regulated by pachytene checkpoint" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUM1" EXACT []

[Term]
id: sgd:S000002719
name: YDR311W
def: "Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair\, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFB1" EXACT []
synonym: "TFIIH/NER complex subunit TFB1" EXACT []

[Term]
id: sgd:S000002720
name: YDR312W
def: "Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog\, SSF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSF2" EXACT []

[Term]
id: sgd:S000002721
name: YDR313C
def: "RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol\(3\)-phosphate; contains a FYVE finger domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIB1" EXACT []
synonym: "phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase" EXACT []

[Term]
id: sgd:S000002722
name: YDR314C
def: "Protein involved in nucleotide excision repair \(NER\); homologous to RAD4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD34" EXACT []

[Term]
id: sgd:S000002723
name: YDR315C
def: "Inositol 1\,3\,4\,5\,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1\,2\,3\,4\,5\,6-hexakisphosphate \(phytate\)\, which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSL1" EXACT []
synonym: "IPK1" EXACT []
synonym: "inositol pentakisphosphate 2-kinase" EXACT []

[Term]
id: sgd:S000002724
name: YDR316W
def: "Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppressor of respiratory defects caused by OXA1 mutations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OMS1" EXACT []

[Term]
id: sgd:S000002725
name: YDR317W
def: "Protein of unknown function involved in DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIM1" EXACT []

[Term]
id: sgd:S000002726
name: YDR318W
def: "Component of the kinetochore sub-complex COMA; COMA \(Ctf19p\, Okp1p\, Mcm21p\, Ame1p\) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-O and fission yeast mal2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTF5" EXACT []
synonym: "MCM21" EXACT []

[Term]
id: sgd:S000002727
name: YDR319C
def: "Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIT2A" EXACT []
synonym: "YFT2" EXACT []

[Term]
id: sgd:S000002728
name: YDR320C
def: "Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AUX1" EXACT []
synonym: "BUD24" EXACT []
synonym: "SWA2" EXACT []

[Term]
id: sgd:S000002729
name: YDR321W
def: "Cytosolic L-asparaginase\, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia\, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASP1" EXACT []
synonym: "asparaginase ASP1" EXACT []

[Term]
id: sgd:S000002730
name: YDR322W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL35" EXACT []
synonym: "YmL35" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL35" EXACT []

[Term]
id: sgd:S000002731
name: YDR323C
def: "Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion\, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP7" EXACT []
synonym: "VAC1" EXACT []
synonym: "VPL21" EXACT []
synonym: "VPS19" EXACT []
synonym: "VPT19" EXACT []

[Term]
id: sgd:S000002732
name: YDR324C
def: "Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP4" EXACT []

[Term]
id: sgd:S000002733
name: YDR325W
def: "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation\, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone \(RSZ\) breakage following Mec1p inactivation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIE1" EXACT []
synonym: "YCG1" EXACT []
synonym: "YCS5" EXACT []

[Term]
id: sgd:S000002734
name: YDR326C
def: "Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog\, YHR080C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSP2" EXACT []

[Term]
id: sgd:S000002735
name: YDR327W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene SKP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002736
name: YDR328C
def: "Evolutionarily conserved kinetochore protein; part of multiple protein complexes\, including the SCF ubiquitin ligase complex\, the CBF3 complex that binds centromeric DNA\, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF3D" EXACT []
synonym: "MGO1" EXACT []
synonym: "SCF ubiquitin ligase subunit SKP1" EXACT []
synonym: "SKP1" EXACT []

[Term]
id: sgd:S000002737
name: YDR329C
def: "Peroxisomal membrane protein \(PMP\); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS3" EXACT []
synonym: "PEX3" EXACT []

[Term]
id: sgd:S000002738
name: YDR330W
def: "UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBX5" EXACT []

[Term]
id: sgd:S000002739
name: YDR331W
def: "ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol \(GPI\) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI8" EXACT []

[Term]
id: sgd:S000002740
name: YDR332W
def: "Double-stranded DNA-dependent helicase of the DExH/D-box family; required for maintenance of the mitochondrial \(mt\) genome; null mutant accumulates double-stranded breaks in mt DNA; localizes to the mt matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC3" EXACT []

[Term]
id: sgd:S000002741
name: YDR333C
def: "Component of the ribosome quality control complex \(RQC\); RQC \(Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p\) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RQC1" EXACT []

[Term]
id: sgd:S000002742
name: YDR334W
def: "Swi2/Snf2-related ATPase; structural component of the SWR1 complex\, which exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWR1" EXACT []
synonym: "chromatin-remodeling protein SWR1" EXACT []

[Term]
id: sgd:S000002743
name: YDR335W
def: "Karyopherin; involved in nuclear import and export of proteins\, including import of replication protein A and export of Far1p and transcription factors Swi5p\, Swi6p\, Msn2p\, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP142" EXACT []
synonym: "MSN5" EXACT []
synonym: "STE21" EXACT []

[Term]
id: sgd:S000002744
name: YDR336W
def: "Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002745
name: YDR337W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS28" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS28" EXACT []

[Term]
id: sgd:S000002746
name: YDR338C
def: "Putative protein of unknown function; member of the multi-drug and toxin extrusion \(MATE\) family of the multidrug/oligosaccharidyl-lipid/polysaccharide \(MOP\) exporter superfamily" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002747
name: YDR339C
def: "Putative PINc domain nuclease; required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU \(small subunit\) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCF1" EXACT []
synonym: "UTP24" EXACT []

[Term]
id: sgd:S000002748
name: YDR340W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002749
name: YDR341C
def: "Arginyl-tRNA synthetase; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog\, MSR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ArgRS" EXACT []
synonym: "RRS1" EXACT []
synonym: "arginine--tRNA ligase" EXACT []

[Term]
id: sgd:S000002750
name: YDR342C
def: "High-affinity glucose transporter; member of the major facilitator superfamily\, nearly identical to Hxt6p\, expressed at high basal levels relative to other HXTs\, expression repressed by high glucose levels; HXT7 has a paralog\, HXT4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT7" EXACT []
synonym: "hexose transporter HXT7" EXACT []

[Term]
id: sgd:S000002751
name: YDR343C
def: "High-affinity glucose transporter; member of the major facilitator superfamily\, nearly identical to Hxt7p\, expressed at high basal levels relative to other HXTs\, repression of expression by high glucose requires SNF3; HXT6 has a paralog\, HXT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT6" EXACT []
synonym: "hexose transporter HXT6" EXACT []

[Term]
id: sgd:S000002752
name: YDR344C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002753
name: YDR345C
def: "Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog\, HXT5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT3" EXACT []
synonym: "hexose transporter HXT3" EXACT []

[Term]
id: sgd:S000002754
name: YDR346C
def: "Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGI1" EXACT []
synonym: "SVF1" EXACT []

[Term]
id: sgd:S000002755
name: YDR347W
def: "Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122\, encoding a COX3-specific translational activator\, and with PET123\, encoding a small subunit mitochondrial ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP1" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRP1" EXACT []

[Term]
id: sgd:S000002756
name: YDR348C
def: "Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein \(GFP\)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog\, YHR097C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAL1" EXACT []

[Term]
id: sgd:S000002757
name: YDR349C
def: "Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPS7" EXACT []

[Term]
id: sgd:S000002758
name: YDR350C
def: "Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP22" EXACT []
synonym: "TCM10" EXACT []

[Term]
id: sgd:S000002759
name: YDR351W
def: "Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog\, SBE22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SBE2" EXACT []

[Term]
id: sgd:S000002760
name: YDR352W
def: "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family\, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPQ2" EXACT []

[Term]
id: sgd:S000002761
name: YDR353W
def: "Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system\, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog\, TRR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRR1" EXACT []
synonym: "thioredoxin-disulfide reductase TRR1" EXACT []

[Term]
id: sgd:S000002762
name: YDR354W
def: "Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRP4" EXACT []
synonym: "anthranilate phosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000002763
name: YDR355C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002764
name: YDR356W
def: "Inner plaque spindle pole body \(SPB\) component; ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUF1" EXACT []
synonym: "SPC110" EXACT []
synonym: "XCM1" EXACT []

[Term]
id: sgd:S000002765
name: YDR357C
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLC1" EXACT []
synonym: "CNL1" EXACT []

[Term]
id: sgd:S000002766
name: YDR358W
def: "Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog\, GGA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GGA1" EXACT []

[Term]
id: sgd:S000002767
name: YDR359C
def: "Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication\, likely due to its requirement for expression of IME1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF1" EXACT []
synonym: "VID21" EXACT []

[Term]
id: sgd:S000002768
name: YDR360W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI7" EXACT []

[Term]
id: sgd:S000002769
name: YDR361C
def: "Essential protein involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4\,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCP1" EXACT []

[Term]
id: sgd:S000002770
name: YDR362C
def: "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex \(TFIIIC\); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFC6" EXACT []
synonym: "tau 91" EXACT []
synonym: "transcription factor TFIIIC subunit TFC6" EXACT []

[Term]
id: sgd:S000002771
name: YDR363W
def: "Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing\, lifespan\, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESC2" EXACT []

[Term]
id: sgd:S000002772
name: YDR364C
def: "Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC40" EXACT []
synonym: "PRP17" EXACT []
synonym: "SLT15" EXACT []
synonym: "SLU4" EXACT []

[Term]
id: sgd:S000002773
name: YDR365C
def: "Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESF1" EXACT []

[Term]
id: sgd:S000002774
name: YDR366C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002775
name: YDR367W
def: "Component of inositol phosphorylceramide \(IPC\) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEI1" EXACT []

[Term]
id: sgd:S000002776
name: YDR368W
def: "NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D\,L-glyceraldehyde\, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog\, GCY1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPR1" EXACT []
synonym: "trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1" EXACT []

[Term]
id: sgd:S000002777
name: YDR369C
def: "Protein required for DNA repair; component of the Mre11 complex\, which is involved in double strand breaks\, meiotic recombination\, telomere maintenance\, and checkpoint signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "XRS2" EXACT []

[Term]
id: sgd:S000002778
name: YDR370C
def: "mRNA 5'-end-capping quality-control protein; has distributive\, 5'-3' exoRNase activity; similar to Rai1p;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DXO1" EXACT []

[Term]
id: sgd:S000002779
name: YDR371W
def: "Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTS2" EXACT []

[Term]
id: sgd:S000002780
name: YDR372C
def: "Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases\, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p\, the major cellular PtdIns4P phosphatase\, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "API1" EXACT []
synonym: "MNN3" EXACT []
synonym: "VPS74" EXACT []

[Term]
id: sgd:S000002781
name: YDR373W
def: "N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRQ1" EXACT []

[Term]
id: sgd:S000002782
name: YDR374C
def: "Posttranscriptional regulator of phosphate metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to PHO4's 3'UTR in a phosphate-dependent manner; contains highly conserved YTH \(YT521-B Homology\) domain that exhibits RNA-binding activity; functional homolog of human YTHDF2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO92" EXACT []

[Term]
id: sgd:S000002783
name: YDR375C
def: "Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane\, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCS1" EXACT []
synonym: "bifunctional AAA family ATPase chaperone/translocase BCS1" EXACT []

[Term]
id: sgd:S000002784
name: YDR376W
def: "Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARH1" EXACT []

[Term]
id: sgd:S000002785
name: YDR377W
def: "Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP17" EXACT []
synonym: "F1F0 ATP synthase subunit f" EXACT []

[Term]
id: sgd:S000002786
name: YDR378C
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM6" EXACT []

[Term]
id: sgd:S000002787
name: YDR379W
def: "GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization\, pheromone response\, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog\, RGA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGA2" EXACT []

[Term]
id: sgd:S000002788
name: YDR380W
def: "Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde\, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO10" EXACT []
synonym: "phenylpyruvate decarboxylase ARO10" EXACT []

[Term]
id: sgd:S000002789
name: YDR381W
def: "Nuclear polyadenylated RNA-binding protein; required for export of poly\(A\)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p\, another REF family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA-binding protein YRA1" EXACT []
synonym: "SHE11" EXACT []
synonym: "YRA1" EXACT []

[Term]
id: sgd:S000002790
name: YDR382W
def: "Ribosomal protein P2 beta; a component of the ribosomal stalk\, which is involved in the interaction between translational elongation factors and the ribosome; free \(non-ribosomal\) P2 stimulates the phosphorylation of the eIF2 alpha subunit \(Sui2p\) by Gcn2p; regulates the accumulation of P1 \(Rpp1Ap and Rpp1Bp\) in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L45" EXACT []
synonym: "P2B" EXACT []
synonym: "RPL45" EXACT []
synonym: "RPP2B" EXACT []
synonym: "YP2beta" EXACT []
synonym: "YPA1" EXACT []
synonym: "ribosomal protein P2B" EXACT []

[Term]
id: sgd:S000002791
name: YDR383C
def: "Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NKP1" EXACT []

[Term]
id: sgd:S000002792
name: YDR384C
def: "Plasma membrane protein\, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATO3" EXACT []
synonym: "putative ammonium permease ATO3" EXACT []

[Term]
id: sgd:S000002793
name: YDR385W
def: "Elongation factor 2 \(EF-2\)\, also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide\, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog\, EFT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFT2" EXACT []
synonym: "elongation factor 2" EXACT []

[Term]
id: sgd:S000002794
name: YDR386W
def: "Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair\, replication fork stability\, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication \(BIR\)\, causing non-reciprocal translocations \(NRTs\); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUS81" EXACT []
synonym: "SLX3" EXACT []

[Term]
id: sgd:S000002795
name: YDR387C
def: "Putative transporter; member of the sugar porter family; YDR387C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002796
name: YDR388W
def: "Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton\, endocytosis\, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RVS167" EXACT []
synonym: "amphiphysin" EXACT []

[Term]
id: sgd:S000002797
name: YDR389W
def: "GTPase activating protein \(GAP\) for Rho1p; regulator of a Tor2p-mediated\, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity \(CWI\) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog\, BAG7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAC7" EXACT []

[Term]
id: sgd:S000002798
name: YDR390C
def: "Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p \(SUMO\) before its conjugation to proteins \(sumoylation\)\, which may play a role in protein targeting; essential for viability;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E1 ubiquitin-activating protein UBA2" EXACT []
synonym: "UAL1" EXACT []
synonym: "UBA2" EXACT []

[Term]
id: sgd:S000002799
name: YDR391C
def: "Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002800
name: YDR392W
def: "Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes\, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPT3" EXACT []
synonym: "transcriptional regulator SPT3" EXACT []

[Term]
id: sgd:S000002801
name: YDR393W
def: "Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane; forms a homo-oligomeric complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM33" EXACT []
synonym: "SHE9" EXACT []

[Term]
id: sgd:S000002802
name: YDR394W
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPT3" EXACT []
synonym: "YNT1" EXACT []
synonym: "YTA2" EXACT []
synonym: "proteasome regulatory particle base subunit RPT3" EXACT []

[Term]
id: sgd:S000002803
name: YDR395W
def: "Nuclear transport factor \(karyopherin\); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p\, Cse1p\, Lph2p\, and the human cellular apoptosis susceptibility protein\, CAS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP108" EXACT []
synonym: "SXM1" EXACT []

[Term]
id: sgd:S000002804
name: YDR396W
def: "Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002805
name: YDR397C
def: "Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCB2" EXACT []
synonym: "YDR1" EXACT []

[Term]
id: sgd:S000002806
name: YDR398W
def: "Subunit of U3-containing Small Subunit \(SSU\) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP5" EXACT []

[Term]
id: sgd:S000002807
name: YDR399W
def: "Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base \(either guanine or hypoxanthine\) to form pyrophosphate and a purine nucleotide \(either guanosine monophosphate or inosine monophosphate\); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRA6" EXACT []
synonym: "HGPRTase" EXACT []
synonym: "HPRT" EXACT []
synonym: "HPT1" EXACT []
synonym: "hypoxanthine phosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000002808
name: YDR400W
def: "Uridine nucleosidase \(uridine-cytidine N-ribohydrolase\); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URH1" EXACT []
synonym: "trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase" EXACT []

[Term]
id: sgd:S000002809
name: YDR401W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002810
name: YDR402C
def: "N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N\,N-bisformyl dityrosine required for spore wall maturation\, homologous to cytochrome P-450s" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYP56" EXACT []
synonym: "DIT2" EXACT []

[Term]
id: sgd:S000002811
name: YDR403W
def: "Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIT1" EXACT []

[Term]
id: sgd:S000002812
name: YDR404C
def: "RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex\, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B16" EXACT []
synonym: "DNA-directed RNA polymerase II subunit RPB7" EXACT []
synonym: "RPB7" EXACT []

[Term]
id: sgd:S000002813
name: YDR405W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP20" EXACT []
synonym: "MRPL41" EXACT []
synonym: "YmL41" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL41" EXACT []

[Term]
id: sgd:S000002814
name: YDR406W
def: "Plasma membrane ATP binding cassette \(ABC\) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p\, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog\, PDR5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR15" EXACT []
synonym: "PDR15" EXACT []

[Term]
id: sgd:S000002815
name: YDR407C
def: "Component of transport protein particle \(TRAPP\) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating intra-Golgi and endosome-Golgi traffic" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS120" EXACT []

[Term]
id: sgd:S000002816
name: YDR408C
def: "Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE8" EXACT []
synonym: "phosphoribosylglycinamide formyltransferase" EXACT []

[Term]
id: sgd:S000002817
name: YDR409W
def: "SUMO/Smt3 ligase; promotes attachment of small ubiquitin-related modifier sumo \(Smt3p\) to proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring; SIZ1 has a paralog\, NFI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIZ1" EXACT []
synonym: "SUMO ligase SIZ1" EXACT []
synonym: "ULL1" EXACT []

[Term]
id: sgd:S000002818
name: YDR410C
def: "Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum\, localizes to the ER membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE14" EXACT []

[Term]
id: sgd:S000002819
name: YDR411C
def: "Endoplasmic reticulum \(ER\) localized protein; involved in ER-associated protein degradation \(ERAD\)\, ER stress\, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFM1" EXACT []

[Term]
id: sgd:S000002820
name: YDR412W
def: "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard \(aerobic\) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP17" EXACT []

[Term]
id: sgd:S000002821
name: YDR413C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002822
name: YDR414C
def: "Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein\, BiP \(Kar2p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERD1" EXACT []
synonym: "LDB2" EXACT []

[Term]
id: sgd:S000002823
name: YDR415C
def: "Putative aminopeptidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative aminopeptidase" EXACT []

[Term]
id: sgd:S000002824
name: YDR416W
def: "Member of the NineTeen Complex \(NTC\); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTC90" EXACT []
synonym: "SYF1" EXACT []

[Term]
id: sgd:S000002825
name: YDR417C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002826
name: YDR418W
def: "Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog\, RPL12A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L11" EXACT []
synonym: "L12B" EXACT []
synonym: "L15B" EXACT []
synonym: "RPL12B" EXACT []
synonym: "YL23" EXACT []
synonym: "ribosomal 60S subunit protein L12B" EXACT []

[Term]
id: sgd:S000002827
name: YDR419W
def: "DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBH1" EXACT []
synonym: "RAD30" EXACT []

[Term]
id: sgd:S000002828
name: YDR420W
def: "Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1\,3 glucan synthesis and bud site selection" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HKR1" EXACT []

[Term]
id: sgd:S000002829
name: YDR421W
def: "Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO80" EXACT []

[Term]
id: sgd:S000002830
name: YDR422C
def: "Alternate beta-subunit of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS \(Kinase-Interacting Sequence\) and ASC \(Association with Snf1 kinase Complex\) domains involved in protein interactions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP1" EXACT []

[Term]
id: sgd:S000002831
name: YDR423C
def: "AP-1-like basic leucine zipper \(bZIP\) transcriptional activator; involved in stress responses\, iron metabolism\, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog\, YAP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAD1" EXACT []
synonym: "YAP2" EXACT []

[Term]
id: sgd:S000002832
name: YDR424C
def: "Cytoplasmic light chain dynein\, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate chain Pac11p that promotes Dyn1p homodimerization\, potentiates motor processivity; Dyn2p-Pac11p complex important for interaction of dynein motor complex with dynactin complex; acts as molecular glue to dimerize\, stabilize Nup82-Nsp1-Nup159 complex module of cytoplasmic pore filaments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DYN2" EXACT []
synonym: "SLC1" EXACT []
synonym: "dynein light chain" EXACT []

[Term]
id: sgd:S000002833
name: YDR425W
def: "Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNX41" EXACT []

[Term]
id: sgd:S000002834
name: YDR426C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002835
name: YDR427W
def: "Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAS7" EXACT []
synonym: "RPN9" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN9" EXACT []

[Term]
id: sgd:S000002836
name: YDR428C
def: "Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA7" EXACT []
synonym: "arylformamidase" EXACT []

[Term]
id: sgd:S000002837
name: YDR429C
def: "eIF3g subunit of the eukaryotic translation initiation factor 3 \(eIF3\); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF35" EXACT []

[Term]
id: sgd:S000002838
name: YDR430C
def: "Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYM1" EXACT []
synonym: "MOP112" EXACT []

[Term]
id: sgd:S000002839
name: YDR431W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002840
name: YDR432W
def: "RNA-binding protein; promotes elongation\, regulates termination\, and carries poly\(A\) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p\, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTR13" EXACT []
synonym: "MTS1" EXACT []
synonym: "NAB1" EXACT []
synonym: "NOP3" EXACT []
synonym: "NPL3" EXACT []
synonym: "mRNA-binding protein NPL3" EXACT []

[Term]
id: sgd:S000002841
name: YDR433W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE22" EXACT []

[Term]
id: sgd:S000002842
name: YDR434W
def: "Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI17" EXACT []

[Term]
id: sgd:S000002843
name: YDR435C
def: "Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit \(Pph21p or Pph22p\)\, which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPM1" EXACT []

[Term]
id: sgd:S000002844
name: YDR436W
def: "Serine/threonine protein phosphatase Z\, isoform of Ppz1p; involved in regulation of potassium transport\, which affects osmotic stability\, cell cycle progression\, and halotolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPZ2" EXACT []

[Term]
id: sgd:S000002845
name: YDR437W
def: "Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol \(GlcNAc-PI\) is the first intermediate in glycosylphosphatidylinositol \(GPI\) anchor synthesis; shares similarity with mammalian PIG-P" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI19" EXACT []

[Term]
id: sgd:S000002846
name: YDR438W
def: "Mitochondrial transporter repressible by thiamine; THI74 has a paralog\, YML018C\, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3\, a thiamine transporter implicated in hypertension" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI74" EXACT []

[Term]
id: sgd:S000002847
name: YDR439W
def: "Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LRS4" EXACT []

[Term]
id: sgd:S000002848
name: YDR440W
def: "Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing\, meiotic checkpoint control\, and DNA damage response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOT1" EXACT []
synonym: "KMT4" EXACT []
synonym: "PCH1" EXACT []
synonym: "histone methyltransferase DOT1" EXACT []

[Term]
id: sgd:S000002849
name: YDR441C
def: "Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase\, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog\, APT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APT2" EXACT []
synonym: "adenine phosphoribosyltransferase APT2" EXACT []

[Term]
id: sgd:S000002850
name: YDR442W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002851
name: YDR443C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED13" EXACT []
synonym: "NUT8" EXACT []
synonym: "RYE3" EXACT []
synonym: "SCA1" EXACT []
synonym: "SRB9" EXACT []
synonym: "SSN2" EXACT []
synonym: "SSX5" EXACT []
synonym: "UME2" EXACT []

[Term]
id: sgd:S000002852
name: YDR444W
def: "Putative hydrolase acting on ester bonds" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative hydrolase" EXACT []

[Term]
id: sgd:S000002853
name: YDR445C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002854
name: YDR446W
def: "Meiosis-specific protein; component of the Synaptonemal Complex \(SC\) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein\, Zip1p; is SUMOlytaed in a Gmc2p manner\, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM11" EXACT []

[Term]
id: sgd:S000002855
name: YDR447C
def: "Ribosomal protein 51 \(rp51\) of the small \(40s\) subunit; homologous to mammalian ribosomal protein S17\, no bacterial homolog; RPS17B has a paralog\, RPS17A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RP51B" EXACT []
synonym: "RPL51B" EXACT []
synonym: "RPS17B" EXACT []
synonym: "S17B" EXACT []
synonym: "S17e" EXACT []
synonym: "ribosomal 40S subunit protein S17B" EXACT []
synonym: "rp51B" EXACT []

[Term]
id: sgd:S000002856
name: YDR448W
def: "Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT \(histone acetyltransferase\) complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADA2" EXACT []
synonym: "SWI8" EXACT []
synonym: "chromatin-binding transcription regulator ADA2" EXACT []

[Term]
id: sgd:S000002857
name: YDR449C
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP6" EXACT []

[Term]
id: sgd:S000002858
name: YDR450W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog\, RPS18B\, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS18A" EXACT []
synonym: "S13" EXACT []
synonym: "S18A" EXACT []
synonym: "ribosomal 40S subunit protein S18A" EXACT []

[Term]
id: sgd:S000002859
name: YDR451C
def: "Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box \(ECB\) elements of cell cycle regulated genes\, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog\, YOX1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YHP1" EXACT []

[Term]
id: sgd:S000002860
name: YDR452W
def: "Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM5" EXACT []
synonym: "PPN1" EXACT []

[Term]
id: sgd:S000002861
name: YDR453C
def: "Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen\, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog\, TSA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSA2" EXACT []
synonym: "cTPxII" EXACT []
synonym: "thioredoxin peroxidase TSA2" EXACT []

[Term]
id: sgd:S000002862
name: YDR454C
def: "Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUK1" EXACT []
synonym: "PUR5" EXACT []
synonym: "guanylate kinase" EXACT []

[Term]
id: sgd:S000002863
name: YDR455C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002864
name: YDR456W
def: "Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9\, which is linked to autism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NHA2" EXACT []
synonym: "NHX1" EXACT []
synonym: "VPL27" EXACT []
synonym: "VPS44" EXACT []
synonym: "bifunctional K:H/Na:H antiporter NHX1" EXACT []

[Term]
id: sgd:S000002865
name: YDR457W
def: "E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase TOM1" EXACT []
synonym: "TOM1" EXACT []

[Term]
id: sgd:S000002866
name: YDR458C
def: "Inner nuclear membrane \(INM\) protein; contains helix-extension-helix \(HEH\) motif\, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog\, SRC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEH2" EXACT []

[Term]
id: sgd:S000002867
name: YDR459C
def: "Palmitoyltransferase with autoacylation activity; likely functions in pathway\(s\) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich \(DHHC-CRD\) domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFA5" EXACT []

[Term]
id: sgd:S000002868
name: YDR460W
def: "Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation\, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIG2" EXACT []
synonym: "TFB3" EXACT []
synonym: "TFIIH/NER complex subunit TFB3" EXACT []

[Term]
id: sgd:S000002869
name: YDR461W
def: "Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification\, N-terminal proteolysis\, and export; also encoded by MFA2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFA1" EXACT []

[Term]
id: sgd:S000002870
name: YDR462W
def: "Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL28" EXACT []
synonym: "YmL28" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL28" EXACT []

[Term]
id: sgd:S000002871
name: YDR463W
def: "Transcription factor; contains a N-terminal regulatory motif \(RI\) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing by SPS \(Ssy1p-Ptr3p-Ssy5p\)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog\, STP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAP1" EXACT []
synonym: "SSY2" EXACT []
synonym: "STP1" EXACT []

[Term]
id: sgd:S000002872
name: YDR464W
def: "Protein of unknown function; involved in negative regulation of expression of spliceosome components PRP4 and PRP3; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPP41" EXACT []

[Term]
id: sgd:S000002873
name: YDR465C
def: "Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 \(L12\) on Arg67; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMT2" EXACT []

[Term]
id: sgd:S000002874
name: YDR466W
def: "Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKH3" EXACT []
synonym: "protein kinase PKH3" EXACT []

[Term]
id: sgd:S000002875
name: YDR467C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002876
name: YDR468C
def: "Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT \(Vps fifty-three\) through interaction with Vps51p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TLG1" EXACT []

[Term]
id: sgd:S000002877
name: YDR469W
def: "Subunit of the COMPASS \(Set1C\) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS25" EXACT []
synonym: "SAF19" EXACT []
synonym: "SDC1" EXACT []

[Term]
id: sgd:S000002878
name: YDR470C
def: "Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UGO1" EXACT []

[Term]
id: sgd:S000002879
name: YDR471W
def: "Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27\, no bacterial homolog; RPL27B has a paralog\, RPL27A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L27B" EXACT []
synonym: "L27e" EXACT []
synonym: "RPL27B" EXACT []
synonym: "ribosomal 60S subunit protein L27B" EXACT []

[Term]
id: sgd:S000002880
name: YDR472W
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS31" EXACT []

[Term]
id: sgd:S000002881
name: YDR473C
def: "Splicing factor; component of the U4/U6-U5 snRNP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP3" EXACT []
synonym: "RNA3" EXACT []

[Term]
id: sgd:S000002883
name: YDR475C
def: "Protein of unknown function; previously annotated as two separate ORFs\, YDR474C and YDR475C\, which were merged as a result of corrections to the systematic reference sequence; JIP4 has a paralog\, YOR019W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JIP4" EXACT []
synonym: "YDR474C" EXACT []

[Term]
id: sgd:S000002884
name: YDR476C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002885
name: YDR477W
def: "AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes\, thermotolerance\, sporulation\, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ubiquitin ligase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMP-activated serine/threonine-protein kinase catalytic subunit SNF1" EXACT []
synonym: "CAT1" EXACT []
synonym: "CCR1" EXACT []
synonym: "GLC2" EXACT []
synonym: "HAF3" EXACT []
synonym: "PAS14" EXACT []
synonym: "SNF1" EXACT []

[Term]
id: sgd:S000002886
name: YDR478W
def: "Ribonuclease MRP complex subunit; ribonuclease \(RNase\) MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNM1" EXACT []

[Term]
id: sgd:S000002887
name: YDR479C
def: "Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size\, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p\, Pex31p\, and Pex32p; forms ER foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX29" EXACT []

[Term]
id: sgd:S000002888
name: YDR480W
def: "MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG2 has a paralog\, DIG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIG2" EXACT []
synonym: "RST2" EXACT []

[Term]
id: sgd:S000002889
name: YDR481C
def: "Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p\, Pho9p\, Pho80p\, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO8" EXACT []
synonym: "alkaline phosphatase PHO8" EXACT []
synonym: "phoH" EXACT []

[Term]
id: sgd:S000002890
name: YDR482C
def: "Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC21" EXACT []

[Term]
id: sgd:S000002891
name: YDR483W
def: "Alpha1\,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog\, KTR6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-mannosyltransferase KRE2" EXACT []
synonym: "KRE2" EXACT []
synonym: "MNT1" EXACT []
synonym: "alpha-1" EXACT []

[Term]
id: sgd:S000002892
name: YDR484W
def: "Component of the GARP \(Golgi-associated retrograde protein\) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi\, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAC2" EXACT []
synonym: "VPS52" EXACT []

[Term]
id: sgd:S000002893
name: YDR485C
def: "Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWC2" EXACT []
synonym: "VPS72" EXACT []

[Term]
id: sgd:S000002894
name: YDR486C
def: "Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHM5" EXACT []
synonym: "MOS10" EXACT []
synonym: "VPS60" EXACT []

[Term]
id: sgd:S000002895
name: YDR487C
def: "3\,4-dihydroxy-2-butanone-4-phosphate synthase \(DHBP synthase\); required for riboflavin biosynthesis from ribulose-5-phosphate\, also has an unrelated function in mitochondrial respiration" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3" EXACT []
synonym: "4-dihydroxy-2-butanone-4-phosphate synthase RIB3" EXACT []
synonym: "RIB3" EXACT []

[Term]
id: sgd:S000002896
name: YDR488C
def: "Dynein intermediate chain\, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex with dynein light chain Dyn2p that promotes Dyn1p homodimerization and potentiates motor processivity; Dyn2p-Pac11p complex is also important for interaction of dynein motor complex with dynactin complex; forms cortical cytoplasmic microtubule capture site with Num1p; essential in the absence of CIN8" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAC11" EXACT []
synonym: "dynein intermediate chain" EXACT []

[Term]
id: sgd:S000002897
name: YDR489W
def: "Subunit of the GINS complex \(Sld5p\, Psf1p\, Psf2p\, Psf3p\); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC105" EXACT []
synonym: "SLD5" EXACT []

[Term]
id: sgd:S000002898
name: YDR490C
def: "Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p\, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p; PKH1 has a paralog\, PKH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKH1" EXACT []
synonym: "serine/threonine protein kinase PKH1" EXACT []

[Term]
id: sgd:S000002899
name: YDR491C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002900
name: YDR492W
def: "Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p\, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog\, IZH4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IZH1" EXACT []

[Term]
id: sgd:S000002901
name: YDR493W
def: "Protein required for assembly of the cytochrome bc\(1\) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels\, which is characteristic of mutations affecting bc\(1\) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM8" EXACT []
synonym: "FMP36" EXACT []
synonym: "MZM1" EXACT []

[Term]
id: sgd:S000002902
name: YDR494W
def: "Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM28" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM28" EXACT []

[Term]
id: sgd:S000002903
name: YDR495C
def: "Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins\, acidification of the vacuolar lumen\, and assembly of the vacuolar H+-ATPase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CORVET complex subunit VPS3" EXACT []
synonym: "PEP6" EXACT []
synonym: "VPL3" EXACT []
synonym: "VPS3" EXACT []
synonym: "VPT17" EXACT []

[Term]
id: sgd:S000002904
name: YDR496C
def: "Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation\, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag\:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUF6" EXACT []

[Term]
id: sgd:S000002905
name: YDR497C
def: "Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog\, ITR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ITR1" EXACT []
synonym: "myo-inositol transporter ITR1" EXACT []

[Term]
id: sgd:S000002906
name: YDR498C
def: "Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum \(ER\); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC20" EXACT []

[Term]
id: sgd:S000002907
name: YDR499W
def: "Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDC2" EXACT []
synonym: "LCD1" EXACT []
synonym: "PIE1" EXACT []

[Term]
id: sgd:S000002908
name: YDR500C
def: "Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37\, no bacterial homolog; RPL37B has a paralog\, RPL37A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L37B" EXACT []
synonym: "L37e" EXACT []
synonym: "L43" EXACT []
synonym: "RPL37B" EXACT []
synonym: "YL35" EXACT []
synonym: "ribosomal 60S subunit protein L37B" EXACT []

[Term]
id: sgd:S000002909
name: YDR501W
def: "Putative transcription factor\, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog\, TOS4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLM2" EXACT []

[Term]
id: sgd:S000002910
name: YDR502C
def: "S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ETH2" EXACT []
synonym: "SAM2" EXACT []
synonym: "methionine adenosyltransferase SAM2" EXACT []

[Term]
id: sgd:S000002911
name: YDR503C
def: "Lipid phosphate phosphatase; catalyzes Mg\(2+\)-independent dephosphorylation of phosphatidic acid \(PA\)\, lysophosphatidic acid\, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPP1" EXACT []
synonym: "phosphatidate phosphatase LPP1" EXACT []

[Term]
id: sgd:S000002912
name: YDR504C
def: "Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPG3" EXACT []

[Term]
id: sgd:S000002913
name: YDR505C
def: "Asn and gln rich protein of unknown function; high-copy suppressor of POL1 \(DNA polymerase alpha\) and partial suppressor of CDC2 \(polymerase delta\) and CDC6 \(pre-RC loading factor\) mutations; overexpression results in growth inhibition; PSP1 has a paralog\, YLR177W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIN5" EXACT []
synonym: "PSP1" EXACT []

[Term]
id: sgd:S000002914
name: YDR506C
def: "Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GMC1" EXACT []

[Term]
id: sgd:S000002915
name: YDR507C
def: "Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog\, KCC4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERC47" EXACT []
synonym: "GIN4" EXACT []
synonym: "protein kinase GIN4" EXACT []

[Term]
id: sgd:S000002916
name: YDR508C
def: "High-affinity glutamine permease; also transports Leu\, Ser\, Thr\, Cys\, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p \(SPS\) sensor of extracellular amino acids; GNP1 has a paralog\, AGP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GNP1" EXACT []
synonym: "glutamine permease GNP1" EXACT []

[Term]
id: sgd:S000002917
name: YDR509W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002918
name: YDR510W
def: "Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion\, chromosome segregation\, APC-mediated proteolysis\, DNA replication and septin ring dynamics; phosphorylated at Ser2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMT3" EXACT []
synonym: "SUMO family protein SMT3" EXACT []

[Term]
id: sgd:S000002919
name: YDR511W
def: "Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACN9" EXACT []
synonym: "SDH7" EXACT []

[Term]
id: sgd:S000002920
name: YDR512C
def: "Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1\, also required for sporulation; contains twin cysteine-x9-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMI1" EXACT []

[Term]
id: sgd:S000002921
name: YDR513W
def: "Cytoplasmic glutaredoxin; thioltransferase\, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins\, also exhibits glutathione peroxidase activity\, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog\, GRX1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX2" EXACT []
synonym: "TTR1" EXACT []
synonym: "dithiol glutaredoxin GRX2" EXACT []

[Term]
id: sgd:S000002922
name: YDR514C
def: "Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog\, GFD2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002923
name: YDR515W
def: "RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog\, SRO9\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLF1" EXACT []
synonym: "SRO99" EXACT []

[Term]
id: sgd:S000002924
name: YDR516C
def: "Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog\, GLK1\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMI2" EXACT []
synonym: "putative glucokinase" EXACT []

[Term]
id: sgd:S000002925
name: YDR517W
def: "Acetylated cis-Golgi protein\, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRH1" EXACT []

[Term]
id: sgd:S000002926
name: YDR518W
def: "Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog\, PDI1\, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EUG1" EXACT []
synonym: "protein disulfide isomerase EUG1" EXACT []

[Term]
id: sgd:S000002927
name: YDR519W
def: "Membrane-bound peptidyl-prolyl cis-trans isomerase \(PPIase\); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FKB2" EXACT []
synonym: "FPR2" EXACT []
synonym: "peptidylprolyl isomerase family protein FPR2" EXACT []

[Term]
id: sgd:S000002928
name: YDR520C
def: "Putative Zn\(II\)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT4" EXACT []
synonym: "URC2" EXACT []

[Term]
id: sgd:S000002929
name: YDR521W
def: "Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002930
name: YDR522C
def: "Protein expressed during sporulation; SPS2 has a paralog\, SPS22\, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS2" EXACT []

[Term]
id: sgd:S000002931
name: YDR523C
def: "Putative protein serine/threonine kinase; expressed at the end of meiosis; localized to nucleus and cytoplasm; required for efficient spore packaging and correct localization of enzymes involved in spore wall synthesis; member of the GCKIII subfamily of STE20 family kinases; multiply phosphorylated on serine and threonine residues; interacts genetically and physically with 14-3-3 proteins Bmh1p and Bmh2p and may be regulated by them" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS1" EXACT []
synonym: "putative serine/threonine protein kinase SPS1" EXACT []

[Term]
id: sgd:S000002932
name: YDR524C
def: "ADP-ribosylation factor \(ARF\) GTPase activating protein \(GAP\) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGE1" EXACT []
synonym: "SAT1" EXACT []

[Term]
id: sgd:S000002933
name: YDR525W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "API2" EXACT []

[Term]
id: sgd:S000002934
name: YDR526C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002935
name: YDR527W
def: "Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p\, Rpb3\, and Rpb11p; has similarity to human RPAP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBA50" EXACT []

[Term]
id: sgd:S000002936
name: YDR528W
def: "Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog\, LRE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HLR1" EXACT []

[Term]
id: sgd:S000002937
name: YDR529C
def: "Subunit 7 of ubiquinol cytochrome-c reductase \(Complex III\); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COR4" EXACT []
synonym: "CRO1" EXACT []
synonym: "QCR7" EXACT []
synonym: "UCR7" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 7" EXACT []

[Term]
id: sgd:S000002938
name: YDR530C
def: "Diadenosine 5'\,5'''-P1\,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis\(5'-nucleosidyl\) tetraphosphates; APA2 has a paralog\, APA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APA2" EXACT []

[Term]
id: sgd:S000002939
name: YDR531W
def: "Pantothenate kinase\, ATP\:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A \(CoA\); transcriptionally regulated by Upc2p via a sterol response element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAB1" EXACT []
synonym: "pantothenate kinase" EXACT []

[Term]
id: sgd:S000002940
name: YDR532C
def: "Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE28" EXACT []

[Term]
id: sgd:S000002941
name: YDR533C
def: "Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance\, diauxic shift\, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily\, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP31" EXACT []

[Term]
id: sgd:S000002942
name: YDR534C
def: "Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol \(GPI\) anchor; involved in the retention of siderophore-iron in the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIT1" EXACT []

[Term]
id: sgd:S000002943
name: YDR535C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YDR535C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002944
name: YDR536W
def: "Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation\, strongly but transiently induced when cells are subjected to osmotic shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STL1" EXACT []
synonym: "glucose-inactivated glycerol proton symporter STL1" EXACT []

[Term]
id: sgd:S000002945
name: YDR537C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps verified ORF PAD1/YDR538W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002946
name: YDR538W
def: "Phenylacrylic acid decarboxylase; confers resistance to cinnamic acid\, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAD1" EXACT []
synonym: "POF1" EXACT []
synonym: "phenylacrylic acid decarboxylase PAD1" EXACT []

[Term]
id: sgd:S000002947
name: YDR539W
def: "Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FDC1" EXACT []
synonym: "putative phenylacrylic acid decarboxylase FDC1" EXACT []

[Term]
id: sgd:S000002948
name: YDR540C
def: "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC4" EXACT []

[Term]
id: sgd:S000002949
name: YDR541C
def: "Putative dihydrokaempferol 4-reductase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "carbonyl reductase (NADPH-dependent)" EXACT []

[Term]
id: sgd:S000002950
name: YDR542W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU10" EXACT []
synonym: "seripauperin PAU10" EXACT []

[Term]
id: sgd:S000002951
name: YDR543C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002952
name: YDR544C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002953
name: YDR545W
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 1" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-1" EXACT []

[Term]
id: sgd:S000002954
name: YEL059C-A
def: "Subunit of the mitochondrial inner membrane peptidase \(IMP\); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOM1" EXACT []

[Term]
id: sgd:S000002955
name: YEL076C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002956
name: YEL075W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEL076W-C" EXACT []

[Term]
id: sgd:S000002957
name: YER007C-A
def: "Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF20" EXACT []
synonym: "TMA20" EXACT []

[Term]
id: sgd:S000002958
name: YER060W-A
def: "Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCY22" EXACT []

[Term]
id: sgd:S000002959
name: YER066C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002960
name: YER093C-A
def: "Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin \(phb1\); contains an intron; YER093C-A has a paralog\, YBL059W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM11" EXACT []
synonym: "GEP8" EXACT []

[Term]
id: sgd:S000002961
name: YER119C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae\, but this is likely due to effects on the overlapping gene SCS2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002964
name: YFL012W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YFL013W-A" EXACT []

[Term]
id: sgd:S000002965
name: YFL017W-A
def: "Core Sm protein Sm G; part of heteroheptameric complex \(with Smb1p\, Smd1p\, Smd2p\, Smd3p\, Sme1p\, and Smx3p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm G" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMX2" EXACT []
synonym: "SNP2" EXACT []
synonym: "Sm G" EXACT []
synonym: "SmG" EXACT []
synonym: "YFL018W-A" EXACT []

[Term]
id: sgd:S000002968
name: YFR024C-A
def: "Protein containing a C-terminal SH3 domain; binds Las17p\, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog\, YSC84\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSB3" EXACT []
synonym: "YFR024C" EXACT []

[Term]
id: sgd:S000002969
name: YGL001C
def: "C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG26" EXACT []
synonym: "sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)" EXACT []

[Term]
id: sgd:S000002970
name: YGL002W
def: "Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog\, ERP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP6" EXACT []

[Term]
id: sgd:S000002971
name: YGL003C
def: "Activator of anaphase-promoting complex/cyclosome \(APC/C\); cell-cycle regulated; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p\, Ase1p\, Cin8p and Fin1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDH1" EXACT []
synonym: "HCT1" EXACT []

[Term]
id: sgd:S000002972
name: YGL004C
def: "Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle \(RP\); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN14" EXACT []

[Term]
id: sgd:S000002973
name: YGL005C
def: "Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COD5" EXACT []
synonym: "COG7" EXACT []

[Term]
id: sgd:S000002974
name: YGL006W
def: "Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMC1" EXACT []
synonym: "calcium-transporting ATPase PMC1" EXACT []

[Term]
id: sgd:S000002975
name: YGL007W
def: "Dubious ORF located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRP1" EXACT []

[Term]
id: sgd:S000002976
name: YGL008C
def: "Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging\, buds emerge with very low levels of Pma1p\, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate \[GAR+\]" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-exporting P2-type ATPase PMA1" EXACT []
synonym: "KTI10" EXACT []
synonym: "PMA1" EXACT []

[Term]
id: sgd:S000002977
name: YGL009C
def: "Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-isopropylmalate dehydratase LEU1" EXACT []
synonym: "LEU1" EXACT []

[Term]
id: sgd:S000002978
name: YGL010W
def: "Protein involved in metabolism of phytosphingosine; not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPO1" EXACT []

[Term]
id: sgd:S000002979
name: YGL011C
def: "Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRC2" EXACT []
synonym: "SCL1" EXACT []
synonym: "proteasome core particle subunit alpha 1" EXACT []

[Term]
id: sgd:S000002980
name: YGL012W
def: "C-24\(28\) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable\, but lack ergosterol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG4" EXACT []
synonym: "delta(24(24(1)))-sterol reductase" EXACT []

[Term]
id: sgd:S000002981
name: YGL013C
def: "Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements \(PDREs\) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog\, PDR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMY1" EXACT []
synonym: "ANT1" EXACT []
synonym: "BOR2" EXACT []
synonym: "CYH3" EXACT []
synonym: "NRA2" EXACT []
synonym: "PDR1" EXACT []
synonym: "SMR2" EXACT []
synonym: "TIL1" EXACT []
synonym: "TPE1" EXACT []
synonym: "TPE3" EXACT []
synonym: "drug-responsive transcription factor PDR1" EXACT []

[Term]
id: sgd:S000002982
name: YGL014W
def: "Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUF4" EXACT []
synonym: "YGL023" EXACT []

[Term]
id: sgd:S000002983
name: YGL015C
def: "Putative protein of unknown function; null mutants accumulate cargo in the Golgi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000002984
name: YGL016W
def: "Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP122" EXACT []
synonym: "PDR6" EXACT []

[Term]
id: sgd:S000002985
name: YGL017W
def: "Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATE1" EXACT []

[Term]
id: sgd:S000002986
name: YGL018C
def: "Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JAC1" EXACT []

[Term]
id: sgd:S000002987
name: YGL019W
def: "Beta regulatory subunit of casein kinase 2 \(CK2\); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2\, comprised of CKA1\, CKA2\, CKB1 and CKB2\, has many substrates including transcription factors and all RNA polymerases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKB1" EXACT []
synonym: "casein kinase 2 regulatory subunit CKB1" EXACT []

[Term]
id: sgd:S000002988
name: YGL020C
def: "Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GET1" EXACT []
synonym: "MDM39" EXACT []

[Term]
id: sgd:S000002989
name: YGL021W
def: "Protein kinase; along with its paralog\, ALK2\, required for proper spindle positioning and nuclear segregation following mitotic arrest\, proper organization of cell polarity factors in mitosis\, proper localization of formins and polarity factors\, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK1 has a paralog\, ALK2\, that arose from the whole genome duplication; similar to mammalian haspins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALK1" EXACT []
synonym: "protein kinase ALK1" EXACT []

[Term]
id: sgd:S000002990
name: YGL022W
def: "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STT3" EXACT []
synonym: "dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3" EXACT []

[Term]
id: sgd:S000002991
name: YGL023C
def: "Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIB2" EXACT []

[Term]
id: sgd:S000002992
name: YGL024W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SST3" EXACT []

[Term]
id: sgd:S000002993
name: YGL025C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRS1" EXACT []
synonym: "MED3" EXACT []
synonym: "PGD1" EXACT []

[Term]
id: sgd:S000002994
name: YGL026C
def: "Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRP5" EXACT []
synonym: "tryptophan synthase TRP5" EXACT []

[Term]
id: sgd:S000002995
name: YGL027C
def: "Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1\,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH41" EXACT []
synonym: "DER7" EXACT []
synonym: "GLS1" EXACT []

[Term]
id: sgd:S000002996
name: YGL028C
def: "Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCW11" EXACT []

[Term]
id: sgd:S000002997
name: YGL029W
def: "Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CGR1" EXACT []

[Term]
id: sgd:S000002998
name: YGL030W
def: "Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L30" EXACT []
synonym: "L30e" EXACT []
synonym: "L32" EXACT []
synonym: "RPL30" EXACT []
synonym: "YL38" EXACT []
synonym: "ribosomal 60S subunit protein L30" EXACT []
synonym: "rp73" EXACT []

[Term]
id: sgd:S000002999
name: YGL031C
def: "Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24\, no bacterial homolog; RPL24A has a paralog\, RPL24B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L24A" EXACT []
synonym: "L24e" EXACT []
synonym: "L30A" EXACT []
synonym: "RPL24A" EXACT []
synonym: "RPL30A" EXACT []
synonym: "YL21" EXACT []
synonym: "ribosomal 60S subunit protein L24A" EXACT []
synonym: "rp29" EXACT []

[Term]
id: sgd:S000003000
name: YGL032C
def: "Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin \(Sag1p\) during agglutination\, modified with O-linked oligomannosyl chains\, linked to anchorage subunit Aga1p via two disulfide bonds" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGA2" EXACT []

[Term]
id: sgd:S000003001
name: YGL033W
def: "Meiosis-specific protein that localizes to chromosomes;preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; contains a second intron at the 3' end; heterodimer of Hop2p-Mnd1p stimulates the activity of Dmc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOP2" EXACT []

[Term]
id: sgd:S000003002
name: YGL034C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003003
name: YGL035C
def: "Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization\, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAT4" EXACT []
synonym: "MIG1" EXACT []
synonym: "SSN1" EXACT []
synonym: "TDS22" EXACT []
synonym: "transcription factor MIG1" EXACT []

[Term]
id: sgd:S000003004
name: YGL036W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003005
name: YGL037C
def: "Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD\(+\) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PNC1" EXACT []
synonym: "nicotinamidase" EXACT []

[Term]
id: sgd:S000003006
name: YGL038C
def: "Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB12" EXACT []
synonym: "NGD29" EXACT []
synonym: "OCH1" EXACT []

[Term]
id: sgd:S000003007
name: YGL039W
def: "Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "carbonyl reductase (NADPH-dependent)" EXACT []

[Term]
id: sgd:S000003008
name: YGL040C
def: "Aminolevulinate dehydratase; a homo-octameric enzyme\, catalyzes the conversion of 5-aminolevulinate to porphobilinogen\, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM2" EXACT []
synonym: "OLE4" EXACT []
synonym: "SLU1" EXACT []
synonym: "porphobilinogen synthase HEM2" EXACT []

[Term]
id: sgd:S000003009
name: YGL041C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003010
name: YGL042C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae\, but this is likely due to effects on the overlapping gene DST1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003011
name: YGL043W
def: "General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DST1" EXACT []
synonym: "P37" EXACT []
synonym: "PPR2" EXACT []
synonym: "S-II" EXACT []
synonym: "SII" EXACT []
synonym: "TFIIS" EXACT []

[Term]
id: sgd:S000003012
name: YGL044C
def: "Component of the cleavage and polyadenylation factor I \(CF I\); CF 1\, composed of the CF 1A complex \(Rna14p\, Rna15p\, Clp1p\, Pcf11p\) and Hrp1\, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on \(GLRO\) assay; required for gene looping and maintenance of genome stability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA15" EXACT []

[Term]
id: sgd:S000003013
name: YGL045W
def: "Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART9" EXACT []
synonym: "PAL3" EXACT []
synonym: "RIM8" EXACT []
synonym: "YGL046W" EXACT []

[Term]
id: sgd:S000003015
name: YGL047W
def: "Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALG13" EXACT []
synonym: "N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13" EXACT []

[Term]
id: sgd:S000003016
name: YGL048C
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIM3" EXACT []
synonym: "CRL3" EXACT []
synonym: "RPT6" EXACT []
synonym: "SCB68" EXACT []
synonym: "SUG1" EXACT []
synonym: "proteasome regulatory particle base subunit RPT6" EXACT []

[Term]
id: sgd:S000003017
name: YGL049C
def: "Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex \(eIF4F\) that also contains eIF4E \(Cdc33p\); associates with the poly\(A\)-binding protein Pab1p\, also interacts with eIF4A \(Tif1p\); TIF4632 has a paralog\, TIF4631\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF4632" EXACT []
synonym: "eIF4G2" EXACT []

[Term]
id: sgd:S000003018
name: YGL050W
def: "tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TYW3" EXACT []

[Term]
id: sgd:S000003019
name: YGL051W
def: "Putative integral membrane protein\, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog\, MST28\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUP240 family protein MST27" EXACT []
synonym: "MST27" EXACT []

[Term]
id: sgd:S000003020
name: YGL052W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003021
name: YGL053W
def: "Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence\, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog\, PRM9\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM8" EXACT []
synonym: "pheromone-regulated DUP240 family protein PRM8" EXACT []

[Term]
id: sgd:S000003022
name: YGL054C
def: "COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog\, ERV15\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV14" EXACT []

[Term]
id: sgd:S000003023
name: YGL055W
def: "Delta\(9\) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM2" EXACT []
synonym: "OLE1" EXACT []
synonym: "stearoyl-CoA 9-desaturase" EXACT []

[Term]
id: sgd:S000003024
name: YGL056C
def: "Protein involved in cell separation during budding; one of two S. cerevisiae homologs \(Sds23p and Sds24p\) of the S. pombe Sds23 protein\, which is implicated in APC/cyclosome regulation; SDS23 has a paralog\, SDS24\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDS23" EXACT []

[Term]
id: sgd:S000003025
name: YGL057C
def: "Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin \(phb1\) and gem1; authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEP7" EXACT []

[Term]
id: sgd:S000003026
name: YGL058W
def: "Ubiquitin-conjugating enzyme \(E2\); involved in postreplication repair as a heterodimer with Rad18p\, DSBR and checkpoint control as a heterodimer with Bre1p\, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p\, as well as endoplasmic reticulum-associated protein degradation \(ERAD\) with Ubr1p in the absence of canonical ER membrane ligases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-conjugating protein RAD6" EXACT []
synonym: "PSO8" EXACT []
synonym: "RAD6" EXACT []
synonym: "UBC2" EXACT []

[Term]
id: sgd:S000003027
name: YGL059W
def: "Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKP2" EXACT []
synonym: "protein kinase PKP2" EXACT []

[Term]
id: sgd:S000003028
name: YGL060W
def: "Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog\, YBP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YBH1" EXACT []
synonym: "YBP2" EXACT []

[Term]
id: sgd:S000003029
name: YGL061C
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); cooperates with Dam1p to connect the DASH complex with microtubules \(MT\); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUO1" EXACT []

[Term]
id: sgd:S000003030
name: YGL062W
def: "Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog\, PYC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PYC1" EXACT []
synonym: "pyruvate carboxylase 1" EXACT []

[Term]
id: sgd:S000003031
name: YGL063W
def: "Mitochondrial tRNA\:pseudouridine synthase; acts at positions 27 and 28\, but not at position 72; efficiently and rapidly targeted to mitochondria\, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog\, PUS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS2" EXACT []
synonym: "pseudouridine synthase PUS2" EXACT []

[Term]
id: sgd:S000003032
name: YGL064C
def: "Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA\, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRH4" EXACT []

[Term]
id: sgd:S000003033
name: YGL065C
def: "Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-mannosyltransferase" EXACT []
synonym: "ALG2" EXACT []
synonym: "GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000003034
name: YGL066W
def: "SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; relocalizes to the cytosol in response to hypoxia; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on \(GLRO\) assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCA7" EXACT []
synonym: "SGF73" EXACT []

[Term]
id: sgd:S000003035
name: YGL067W
def: "NADH diphosphatase \(pyrophosphatase\); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAD(+) diphosphatase" EXACT []
synonym: "NPY1" EXACT []

[Term]
id: sgd:S000003036
name: YGL068W
def: "Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNP1" EXACT []
synonym: "mitochondrial nucleoid protein MNP1" EXACT []

[Term]
id: sgd:S000003037
name: YGL069C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF3" EXACT []

[Term]
id: sgd:S000003038
name: YGL070C
def: "RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B12.6" EXACT []
synonym: "DNA-directed RNA polymerase II core subunit RPB9" EXACT []
synonym: "RPB9" EXACT []
synonym: "SHI" EXACT []
synonym: "SSU73" EXACT []

[Term]
id: sgd:S000003039
name: YGL071W
def: "Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p\, Grx4p\, and Fra2p\, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog\, AFT2\, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFT1" EXACT []
synonym: "DNA-binding transcription factor AFT1" EXACT []
synonym: "RCS1" EXACT []

[Term]
id: sgd:S000003040
name: YGL072C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin\, cycloheximide and H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003041
name: YGL073W
def: "Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses\, including hyperthermia; recognizes variable heat shock elements \(HSEs\) consisting of inverted NGAAN repeats; monitors translational status of cell at the ribosome through an RQC \(Ribosomal Quality Control\)-mediated translation-stress signal; involved in diauxic shift; posttranslationally regulated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EXA3" EXACT []
synonym: "HSF1" EXACT []
synonym: "MAS3" EXACT []
synonym: "stress-responsive transcription factor HSF1" EXACT []

[Term]
id: sgd:S000003042
name: YGL074C
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003043
name: YGL075C
def: "Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog\, CSM4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMC1" EXACT []
synonym: "MPS2" EXACT []

[Term]
id: sgd:S000003044
name: YGL076C
def: "Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain \(NDB2\); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog\, RPL7B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L30" EXACT []
synonym: "L6A" EXACT []
synonym: "L7A" EXACT []
synonym: "RPL7A" EXACT []
synonym: "YL8" EXACT []
synonym: "ribosomal 60S subunit protein L7A" EXACT []
synonym: "rp11" EXACT []

[Term]
id: sgd:S000003045
name: YGL077C
def: "Plasma membrane transporter for choline\, ethanolamine\, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTR1" EXACT []
synonym: "HNM1" EXACT []

[Term]
id: sgd:S000003046
name: YGL078C
def: "RNA-Dependent ATPase\, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth\, but deletion causes severe slow-growth phenotype" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP3" EXACT []
synonym: "RNA-dependent ATPase DBP3" EXACT []

[Term]
id: sgd:S000003047
name: YGL079W
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIB1" EXACT []
synonym: "KXD1" EXACT []

[Term]
id: sgd:S000003048
name: YGL080W
def: "Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Mpc1p and either Mpc2p or Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP37" EXACT []
synonym: "MPC1" EXACT []

[Term]
id: sgd:S000003049
name: YGL081W
def: "Putative protein of unknown function; non-essential gene; interacts genetically with CHS5\, a gene involved in chitin biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003050
name: YGL082W
def: "Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; not an essential gene; YGL082W has a paralog\, YPL191C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003051
name: YGL083W
def: "Putative kinase; suppressor of GTPase mutant; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCY1" EXACT []

[Term]
id: sgd:S000003052
name: YGL084C
def: "Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; GUP1 has a paralog\, GUP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUP1" EXACT []

[Term]
id: sgd:S000003053
name: YGL085W
def: "Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCL3" EXACT []

[Term]
id: sgd:S000003054
name: YGL086W
def: "Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p \(aka Kap121p\) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAD1" EXACT []
synonym: "coiled-coil domain-containing protein MAD1" EXACT []

[Term]
id: sgd:S000003055
name: YGL087C
def: "Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p\, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins\, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2  ubiquitin-conjugating protein MMS2" EXACT []
synonym: "MMS2" EXACT []

[Term]
id: sgd:S000003056
name: YGL088W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps snR10\, a snoRNA required for preRNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003057
name: YGL089C
def: "Mating pheromone alpha-factor\, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF\(ALPHA\)1\, which is more highly expressed; MF\(ALPHA\)2 has a paralog\, MF\(ALPHA\)1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MF(ALPHA)2" EXACT []

[Term]
id: sgd:S000003058
name: YGL090W
def: "Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIF1" EXACT []

[Term]
id: sgd:S000003059
name: YGL091C
def: "Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NBP35" EXACT []

[Term]
id: sgd:S000003060
name: YGL092W
def: "Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex \(with roles in NPC biogenesis and localization of genes to the nuclear periphery\)\, and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP145" EXACT []
synonym: "RAT10" EXACT []

[Term]
id: sgd:S000003061
name: YGL093W
def: "Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC105" EXACT []

[Term]
id: sgd:S000003062
name: YGL094C
def: "Catalytic subunit of the Pan2p-Pan3p poly\(A\)-ribonuclease complex; complex acts to control poly\(A\) tail length and regulate the stoichiometry and activity of postreplication repair complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAN2" EXACT []

[Term]
id: sgd:S000003063
name: YGL095C
def: "Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STT10" EXACT []
synonym: "VPL28" EXACT []
synonym: "VPS45" EXACT []

[Term]
id: sgd:S000003064
name: YGL096W
def: "Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog\, CUP9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS8" EXACT []

[Term]
id: sgd:S000003065
name: YGL097W
def: "Nucleotide exchange factor for Gsp1p; localizes to the nucleus\, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTR1" EXACT []
synonym: "PRP20" EXACT []
synonym: "SRM1" EXACT []
synonym: "TSM437" EXACT []

[Term]
id: sgd:S000003066
name: YGL098W
def: "Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p\, Sec20p and Ufe1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLT1" EXACT []
synonym: "USE1" EXACT []

[Term]
id: sgd:S000003067
name: YGL099W
def: "Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE35" EXACT []
synonym: "LSG1" EXACT []
synonym: "putative GTPase LSG1" EXACT []

[Term]
id: sgd:S000003068
name: YGL100W
def: "Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex \(NPC\) and the Seh1-associated \(SEA\) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEH1" EXACT []

[Term]
id: sgd:S000003069
name: YGL101W
def: "Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog\, YBR242W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003070
name: YGL102C
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003071
name: YGL103W
def: "Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYH2" EXACT []
synonym: "L15" EXACT []
synonym: "L28" EXACT []
synonym: "L29" EXACT []
synonym: "RPL28" EXACT []
synonym: "YL24" EXACT []
synonym: "ribosomal 60S subunit protein L28" EXACT []
synonym: "rp44" EXACT []

[Term]
id: sgd:S000003072
name: YGL104C
def: "Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog\, YBR241C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS73" EXACT []

[Term]
id: sgd:S000003073
name: YGL105W
def: "Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery\, stimulating catalysis\, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC1" EXACT []

[Term]
id: sgd:S000003074
name: YGL106W
def: "Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p\, Iqg1p\, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLC1" EXACT []

[Term]
id: sgd:S000003075
name: YGL107C
def: "Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog\, YBR238C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMD9" EXACT []

[Term]
id: sgd:S000003076
name: YGL108C
def: "Protein of unknown function\, predicted to be palmitoylated; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003077
name: YGL109W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003078
name: YGL110C
def: "Protein of unknown function; has a CUE domain that binds ubiquitin\, which may facilitate intramolecular monoubiquitination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUE3" EXACT []

[Term]
id: sgd:S000003079
name: YGL111W
def: "Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSA1" EXACT []

[Term]
id: sgd:S000003080
name: YGL112C
def: "Subunit \(60 kDa\) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification\, similar to histone H4; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF6" EXACT []
synonym: "TAF60" EXACT []
synonym: "TafII60" EXACT []

[Term]
id: sgd:S000003081
name: YGL113W
def: "Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLD3" EXACT []

[Term]
id: sgd:S000003082
name: YGL114W
def: "Putative protein of unknown function; predicted member of the oligopeptide transporter \(OPT\) family of membrane transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPT3" EXACT []

[Term]
id: sgd:S000003083
name: YGL115W
def: "Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes\, represses glucose-induced genes; role in sporulation\, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMP-activated serine/threonine-protein kinase regulatory subunit SNF4" EXACT []
synonym: "CAT3" EXACT []
synonym: "SCI1" EXACT []
synonym: "SNF4" EXACT []

[Term]
id: sgd:S000003084
name: YGL116W
def: "Activator of anaphase-promoting complex/cyclosome \(APC/C\); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins\, Pds1p\, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC20" EXACT []
synonym: "PAC5" EXACT []
synonym: "ubiquitin-protein transferase activating protein CDC20" EXACT []

[Term]
id: sgd:S000003085
name: YGL117W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003086
name: YGL118C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003087
name: YGL119W
def: "Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9\, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog\, YBR230W-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC1" EXACT []
synonym: "COQ8" EXACT []
synonym: "protein kinase COQ8" EXACT []

[Term]
id: sgd:S000003088
name: YGL120C
def: "RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2\, U5\, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAH-box ATP-dependent RNA helicase PRP43" EXACT []
synonym: "JA1" EXACT []
synonym: "PRP43" EXACT []

[Term]
id: sgd:S000003089
name: YGL121C
def: "Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPG1" EXACT []

[Term]
id: sgd:S000003090
name: YGL122C
def: "Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly\(A\) tail length control; binds nuclear pore protein Mlp1p; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAB2" EXACT []
synonym: "mRNA-binding protein NAB2" EXACT []

[Term]
id: sgd:S000003091
name: YGL123W
def: "Protein component of the small \(40S\) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I \(CTDK-I\) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS2" EXACT []
synonym: "RPS4" EXACT []
synonym: "S2" EXACT []
synonym: "S4" EXACT []
synonym: "S5" EXACT []
synonym: "SUP138" EXACT []
synonym: "SUP38" EXACT []
synonym: "SUP44" EXACT []
synonym: "Ys5" EXACT []
synonym: "ribosomal 40S subunit protein S2" EXACT []
synonym: "rp12" EXACT []

[Term]
id: sgd:S000003092
name: YGL124C
def: "Subunit of a heterodimeric guanine nucleotide exchange factor \(GEF\); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p\, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy\, the CVT pathway and mitophagy; potential Cdc28 substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AUT12" EXACT []
synonym: "MON1" EXACT []

[Term]
id: sgd:S000003093
name: YGL125W
def: "Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5\,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET11" EXACT []
synonym: "MET13" EXACT []
synonym: "MRPL45" EXACT []
synonym: "methylenetetrahydrofolate reductase (NAD(P)H) MET13" EXACT []

[Term]
id: sgd:S000003094
name: YGL126W
def: "Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIT2B" EXACT []
synonym: "SCS3" EXACT []

[Term]
id: sgd:S000003095
name: YGL127C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED31" EXACT []
synonym: "SOH1" EXACT []

[Term]
id: sgd:S000003096
name: YGL128C
def: "Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC23" EXACT []

[Term]
id: sgd:S000003097
name: YGL129C
def: "Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM23" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM23" EXACT []

[Term]
id: sgd:S000003098
name: YGL130W
def: "Guanylyltransferase involved in mRNA 5' capping; subunit of the mRNA capping enzyme\, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p\, the mRNA 5?-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEG1" EXACT []

[Term]
id: sgd:S000003099
name: YGL131C
def: "Subunit of Snt2C complex\, RING finger ubiquitin ligase \(E3\); physically associates with Ecm5p and Rpd3p; along with Ecm5p\, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p\, independently of Rpd3p\, to promoters of stress response genes upon oxidative stress; involved in ubiquitylation\, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding E3 ubiquitin-protein ligase SNT2" EXACT []
synonym: "SNT2" EXACT []

[Term]
id: sgd:S000003100
name: YGL132W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003101
name: YGL133W
def: "Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes\, repression of early meiotic genes during mitotic growth\, and repression of INO1; similar to mammalian Acf1p\, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor \(ACF\) complex; ITC1 has a paralog\, YPL216W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ITC1" EXACT []

[Term]
id: sgd:S000003102
name: YGL134W
def: "Pho85p cyclin; recruits\, activates\, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog\, PCL8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL10" EXACT []

[Term]
id: sgd:S000003103
name: YGL135W
def: "Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog\, RPL1A\, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L1" EXACT []
synonym: "L1B" EXACT []
synonym: "RPL1B" EXACT []
synonym: "SSM2" EXACT []
synonym: "ribosomal 60S subunit protein L1B" EXACT []

[Term]
id: sgd:S000003104
name: YGL136C
def: "Mitochondrial 2' O-ribose methyltransferase; required for methylation of U\(2791\) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p\, and to E. coli FtsJ/RrmJ" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRM2" EXACT []

[Term]
id: sgd:S000003105
name: YGL137W
def: "Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC27" EXACT []

[Term]
id: sgd:S000003106
name: YGL138C
def: "Putative protein of unknown function; has no significant sequence similarity to any known protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003107
name: YGL139W
def: "Putative FAD transporter\, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog\, FLC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLC3" EXACT []
synonym: "HUF3" EXACT []

[Term]
id: sgd:S000003108
name: YGL140C
def: "Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003109
name: YGL141W
def: "Multiubiquitin chain assembly factor \(E4\); proteasome processivity factor that elongates polyUb chains on substrates\, opposing Ubp6p\, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUL5" EXACT []
synonym: "ubiquitin-ubiquitin ligase HUL5" EXACT []

[Term]
id: sgd:S000003110
name: YGL142C
def: "Integral membrane protein involved in GPI anchor synthesis; putative alpha 1\,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol \(GPI\) core structure; human PIG-Bp is a functional homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI10" EXACT []

[Term]
id: sgd:S000003111
name: YGL143C
def: "Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRF1" EXACT []

[Term]
id: sgd:S000003112
name: YGL144C
def: "Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROG1" EXACT []
synonym: "putative lipase ROG1" EXACT []

[Term]
id: sgd:S000003113
name: YGL145W
def: "Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIP1" EXACT []
synonym: "TIP20" EXACT []

[Term]
id: sgd:S000003114
name: YGL146C
def: "Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans\, but no significant homology to other known proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT6" EXACT []

[Term]
id: sgd:S000003115
name: YGL147C
def: "Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog\, RPL9B\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L6" EXACT []
synonym: "L8A" EXACT []
synonym: "L9A" EXACT []
synonym: "RPL9A" EXACT []
synonym: "YL11" EXACT []
synonym: "ribosomal 60S subunit protein L9A" EXACT []
synonym: "rp24" EXACT []

[Term]
id: sgd:S000003116
name: YGL148W
def: "Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate \(EPSP\) to form chorismate\, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO2" EXACT []
synonym: "bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2" EXACT []

[Term]
id: sgd:S000003117
name: YGL149W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003118
name: YGL150C
def: "ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INO80" EXACT []
synonym: "chromatin-remodeling ATPase INO80" EXACT []

[Term]
id: sgd:S000003119
name: YGL151W
def: "Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED5" EXACT []
synonym: "NUT1" EXACT []
synonym: "SSX4" EXACT []

[Term]
id: sgd:S000003120
name: YGL152C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003121
name: YGL153W
def: "Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 \(Pex5p\) and PTS2 \(Pex7p\)\, peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX14" EXACT []

[Term]
id: sgd:S000003122
name: YGL154C
def: "Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p \(alpha-aminoadipate reductase\) into catalytically active holo-form by posttranslational addition of phosphopantetheine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS5" EXACT []

[Term]
id: sgd:S000003123
name: YGL155W
def: "Beta subunit of geranylgeranyltransferase type I; catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAL1" EXACT []
synonym: "CDC43" EXACT []
synonym: "protein geranylgeranyltransferase type I subunit CDC43" EXACT []

[Term]
id: sgd:S000003124
name: YGL156W
def: "Vacuolar alpha mannosidase; involved in free oligosaccharide \(fOS\) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMS1" EXACT []

[Term]
id: sgd:S000003125
name: YGL157W
def: "NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARI1" EXACT []
synonym: "carbonyl reductase (NADPH-dependent) ARI1" EXACT []

[Term]
id: sgd:S000003126
name: YGL158W
def: "Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog\, RCK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCK1" EXACT []
synonym: "putative serine/threonine protein kinase RCK1" EXACT []

[Term]
id: sgd:S000003127
name: YGL159W
def: "Putative protein of unknown function; deletion mutant has no detectable phenotype" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003128
name: YGL160W
def: "NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases \(NOX enzymes\); has similarity to iron/copper reductases \(FRE1-8\)\, particularly Fre8p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM14" EXACT []
synonym: "YNO1" EXACT []

[Term]
id: sgd:S000003129
name: YGL161C
def: "Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIP5" EXACT []

[Term]
id: sgd:S000003130
name: YGL162W
def: "Transcription factor of the Zn\(II\)2Cys6 family; positively regulates genes involved in sterol uptake under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating with SUT2 by repressing expression of genes which act as mating inhibitors; relocalizes from nucleus to cytoplasm upon DNA replication stress; SUT1 has a paralog\, SUT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUT1" EXACT []

[Term]
id: sgd:S000003131
name: YGL163C
def: "DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-dependent ATPase RAD54" EXACT []
synonym: "RAD54" EXACT []
synonym: "XRS1" EXACT []

[Term]
id: sgd:S000003132
name: YGL164C
def: "RanGTP-binding protein; inhibits RanGAP1 \(Rna1p\)-mediated GTP hydrolysis of RanGTP \(Gsp1p\); shares similarity to proteins in other fungi but not in higher eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YRB30" EXACT []

[Term]
id: sgd:S000003133
name: YGL165C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003134
name: YGL166W
def: "Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog\, HAA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACE1" EXACT []
synonym: "CUP2" EXACT []

[Term]
id: sgd:S000003135
name: YGL167C
def: "High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; D53A mutant \(Mn2+ transporting\) is rapamycin sensitive\, Q783A mutant \(Ca2+ transporting\) is rapamycin resistant; Mn2+ transport into Golgi lumen appears to be required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSD1" EXACT []
synonym: "Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1" EXACT []
synonym: "LDB1" EXACT []
synonym: "PMR1" EXACT []
synonym: "SSC1" EXACT []

[Term]
id: sgd:S000003136
name: YGL168W
def: "Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUR1" EXACT []

[Term]
id: sgd:S000003137
name: YGL169W
def: "Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine \(t6A\) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUA5" EXACT []

[Term]
id: sgd:S000003138
name: YGL170C
def: "Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO74" EXACT []

[Term]
id: sgd:S000003139
name: YGL171W
def: "RNA-dependent ATPase; involved in pre-rRNA processing at sites A0\, A1\, and A2\, and in control of cell cycle progression; contains two upstream open reading frames \(uORFs\) in 5' untranslated region which regulate translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA-dependent ATPase ROK1" EXACT []
synonym: "ROK1" EXACT []

[Term]
id: sgd:S000003140
name: YGL172W
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex \(NPC\) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins \(Nsp1p and Nup57p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP49" EXACT []
synonym: "NSP49" EXACT []
synonym: "NUP49" EXACT []

[Term]
id: sgd:S000003141
name: YGL173C
def: "Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing \(P\) bodies involved in mRNA decay; also enters the nucleus and positively regulates transcription initiation and elongation; plays a role in microtubule-mediated processes\, filamentous growth\, ribosomal RNA maturation\, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DST2" EXACT []
synonym: "KEM1" EXACT []
synonym: "RAR5" EXACT []
synonym: "SEP1" EXACT []
synonym: "SKI1" EXACT []
synonym: "XRN1" EXACT []
synonym: "chromatin-binding exonuclease XRN1" EXACT []

[Term]
id: sgd:S000003142
name: YGL174W
def: "Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD13" EXACT []
synonym: "CWC26" EXACT []

[Term]
id: sgd:S000003143
name: YGL175C
def: "Endonuclease required for telomere elongation; also required for telomeric 5' C-rich strand resection; involved in processing hairpin DNA structures with MRX complex; involved in double-strand break repair; sumoylation and phosphorylation both required for function; exists in form of inactive oligomers that are transiently released into smaller active units by a series of phosphorylations; DNA damage triggers removal of Sae2p\, so active Sae2p is present only transiently" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COM1" EXACT []
synonym: "SAE2" EXACT []
synonym: "ssDNA endodeoxyribonuclease SAE2" EXACT []

[Term]
id: sgd:S000003144
name: YGL176C
def: "Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003145
name: YGL177W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003146
name: YGL178W
def: "mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs\, including those involved in mating type switching\, cell wall integrity\, chronological lifespan\, chromatin modification\, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation\, decapping\, and decay; also interacts with the Caf20p translational initiation repressor\, affecting its mRNA target specificity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTR1" EXACT []
synonym: "MPT5" EXACT []
synonym: "PUF5" EXACT []
synonym: "UTH4" EXACT []

[Term]
id: sgd:S000003147
name: YGL179C
def: "Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1\, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog\, SAK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS3" EXACT []
synonym: "serine/threonine protein kinase TOS3" EXACT []

[Term]
id: sgd:S000003148
name: YGL180W
def: "Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting \(Cvt\) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; essential for cell cycle progression from G2/M to G1 under nitrogen starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG1" EXACT []
synonym: "ATG1" EXACT []
synonym: "AUT3" EXACT []
synonym: "CVT10" EXACT []
synonym: "serine/threonine protein kinase ATG1" EXACT []

[Term]
id: sgd:S000003149
name: YGL181W
def: "Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain\, a C-terminal glutamine-rich region\, and a UBA \(ubiquitin associated\) domain; gts1 mutations affect budding\, cell size\, heat tolerance\, sporulation\, life span\, ultradian rhythms\, endocytosis; expression oscillates in a pattern similar to metabolic oscillations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FHT1" EXACT []
synonym: "GTS1" EXACT []
synonym: "LSR1" EXACT []

[Term]
id: sgd:S000003150
name: YGL182C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003151
name: YGL183C
def: "Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p\, which is involved in chromosome pairing and repair of meiotic double-strand breaks" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MND1" EXACT []

[Term]
id: sgd:S000003152
name: YGL184C
def: "Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STR3" EXACT []
synonym: "cystathionine beta-lyase STR3" EXACT []

[Term]
id: sgd:S000003153
name: YGL185C
def: "Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative hydroxyacid dehydrogenase" EXACT []

[Term]
id: sgd:S000003154
name: YGL186C
def: "Plasma membrane pyridoxine \(vitamin B6\) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p\, Fcy2p\, and Fcy22p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPN1" EXACT []

[Term]
id: sgd:S000003155
name: YGL187C
def: "Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX4" EXACT []
synonym: "cytochrome c oxidase subunit IV" EXACT []

[Term]
id: sgd:S000003156
name: YGL188C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003157
name: YGL189C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S26\, no bacterial homolog; RPS26A has a paralog\, RPS26B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS26" EXACT []
synonym: "RPS26A" EXACT []
synonym: "S26A" EXACT []
synonym: "S26e" EXACT []
synonym: "ribosomal 40S subunit protein S26A" EXACT []

[Term]
id: sgd:S000003158
name: YGL190C
def: "Non-essential regulatory subunit B of protein phosphatase 2A \(PP2A\); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC55" EXACT []
synonym: "TMR4" EXACT []
synonym: "protein phosphatase 2A regulatory subunit CDC55" EXACT []

[Term]
id: sgd:S000003159
name: YGL191W
def: "Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX13" EXACT []
synonym: "cytochrome c oxidase subunit VIa" EXACT []

[Term]
id: sgd:S000003160
name: YGL192W
def: "mRNA N6-adenosine methyltransferase required for entry into meiosis; mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1\, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 \(MT-A70\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IME4" EXACT []
synonym: "SPO8" EXACT []
synonym: "mRNA (N6-adenosine)-methyltransferase" EXACT []

[Term]
id: sgd:S000003161
name: YGL193C
def: "Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains\, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003162
name: YGL194C
def: "Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex\, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOS2" EXACT []
synonym: "RTL1" EXACT []
synonym: "histone deacetylase HOS2" EXACT []

[Term]
id: sgd:S000003163
name: YGL195W
def: "Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAS103" EXACT []
synonym: "GCN1" EXACT []
synonym: "NDR1" EXACT []

[Term]
id: sgd:S000003164
name: YGL196W
def: "D-serine dehydratase \(aka D-serine ammonia-lyase\); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "D-serine ammonia-lyase DSD1" EXACT []
synonym: "DSD1" EXACT []

[Term]
id: sgd:S000003165
name: YGL197W
def: "Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required\, with Pmd1p\, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog\, PMD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDS3" EXACT []

[Term]
id: sgd:S000003166
name: YGL198W
def: "Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIP4" EXACT []

[Term]
id: sgd:S000003167
name: YGL199C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003168
name: YGL200C
def: "Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BST2" EXACT []
synonym: "EMP24" EXACT []

[Term]
id: sgd:S000003169
name: YGL201C
def: "Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCM DNA helicase complex subunit MCM6" EXACT []
synonym: "MCM6" EXACT []

[Term]
id: sgd:S000003170
name: YGL202W
def: "Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO8" EXACT []
synonym: "bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase" EXACT []

[Term]
id: sgd:S000003171
name: YGL203C
def: "Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEX1" EXACT []

[Term]
id: sgd:S000003172
name: YGL204C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003173
name: YGL205W
def: "Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOX1" EXACT []
synonym: "POX1" EXACT []
synonym: "acyl-CoA oxidase" EXACT []

[Term]
id: sgd:S000003174
name: YGL206C
def: "Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain \(CLC1\) is thought to regulate function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHC1" EXACT []
synonym: "SWA5" EXACT []
synonym: "clathrin heavy chain" EXACT []

[Term]
id: sgd:S000003175
name: YGL207W
def: "Subunit of the heterodimeric FACT complex \(Spt16p-Pob3p\); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp\, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; SPT16 specifically required for diauxic shift-induced H2B deposition onto rDNA genes; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC68" EXACT []
synonym: "SPT16" EXACT []
synonym: "SSF1" EXACT []
synonym: "chromatin-remodeling protein SPT16" EXACT []

[Term]
id: sgd:S000003176
name: YGL208W
def: "One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog\, GAL83\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP2" EXACT []
synonym: "SPM2" EXACT []

[Term]
id: sgd:S000003177
name: YGL209W
def: "Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion\, where it interacts with Ups1p\, antagonizes mitochondrial fission factor Dnm1p\, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIG2" EXACT []
synonym: "MLZ1" EXACT []

[Term]
id: sgd:S000003178
name: YGL210W
def: "Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog\, YPT31\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT32" EXACT []
synonym: "YPT32" EXACT []

[Term]
id: sgd:S000003179
name: YGL211W
def: "Protein required for uridine thiolation of Gln\, Lys\, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln\, Lys\, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCS6" EXACT []
synonym: "TUC1" EXACT []
synonym: "YGL210W-A" EXACT []

[Term]
id: sgd:S000003180
name: YGL212W
def: "Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain \(phosphoinositide-binding module\) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAM7" EXACT []
synonym: "VPL24" EXACT []
synonym: "VPS43" EXACT []

[Term]
id: sgd:S000003181
name: YGL213C
def: "Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REC103" EXACT []
synonym: "SKI complex subunit WD repeat protein SKI8" EXACT []
synonym: "SKI8" EXACT []

[Term]
id: sgd:S000003182
name: YGL214W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003183
name: YGL215W
def: "Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLG1" EXACT []

[Term]
id: sgd:S000003184
name: YGL216W
def: "Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation\, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIP3" EXACT []
synonym: "tubulin-dependent ATPase KIP3" EXACT []

[Term]
id: sgd:S000003185
name: YGL217C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003186
name: YGL218W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF1" EXACT []

[Term]
id: sgd:S000003187
name: YGL219C
def: "Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERMES complex subunit MDM34" EXACT []
synonym: "MDM34" EXACT []
synonym: "MMM2" EXACT []

[Term]
id: sgd:S000003188
name: YGL220W
def: "Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p\, Grx3p\, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM15" EXACT []
synonym: "FRA2" EXACT []

[Term]
id: sgd:S000003189
name: YGL221C
def: "Protein of unknown function; similar to Listeria monocytogenes major sigma factor \(rpoD gene product\); the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIF3" EXACT []

[Term]
id: sgd:S000003190
name: YGL222C
def: "RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog\, EDC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EDC1" EXACT []

[Term]
id: sgd:S000003191
name: YGL223C
def: "Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COD3" EXACT []
synonym: "COG1" EXACT []
synonym: "LDB11" EXACT []
synonym: "SEC36" EXACT []

[Term]
id: sgd:S000003192
name: YGL224C
def: "Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II\, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog\, PHM8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDT1" EXACT []
synonym: "SSM1" EXACT []

[Term]
id: sgd:S000003193
name: YGL225W
def: "Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog\, HVG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GOG5" EXACT []
synonym: "LDB3" EXACT []
synonym: "VAN2" EXACT []
synonym: "VIG4" EXACT []
synonym: "VRG4" EXACT []

[Term]
id: sgd:S000003194
name: YGL226C-A
def: "Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OST5" EXACT []

[Term]
id: sgd:S000003195
name: YGL226W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC3" EXACT []

[Term]
id: sgd:S000003196
name: YGL227W
def: "Central component of GID Complex\, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH\, CTLH\, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GID1" EXACT []
synonym: "VID30" EXACT []
synonym: "glucose-induced degradation complex subunit VID30" EXACT []

[Term]
id: sgd:S000003197
name: YGL228W
def: "Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest; SHE10 has a paralog\, OSW7/YFR039C\, that arose from the whole genome duplication and deletion of both SHE10 and OWS7 results in reduced dityrosine fluorescence from the spore wall relative to other mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHE10" EXACT []

[Term]
id: sgd:S000003198
name: YGL229C
def: "Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p\, including Sap155p\, Sap185p\, and Sap190p; SAP4 has a paralog\, SAP155\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP4" EXACT []

[Term]
id: sgd:S000003199
name: YGL230C
def: "Putative protein of unknown function; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003200
name: YGL231C
def: "Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4\, fly CG11137\, human TMM85" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMC4" EXACT []

[Term]
id: sgd:S000003201
name: YGL232W
def: "Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N\(4\)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAN1" EXACT []

[Term]
id: sgd:S000003202
name: YGL233W
def: "Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active\, GTP-bound Sec4p\, a Rab family GTPase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC15" EXACT []

[Term]
id: sgd:S000003203
name: YGL234W
def: "Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE5,7" EXACT []
synonym: "bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase" EXACT []

[Term]
id: sgd:S000003204
name: YGL235W
def: "Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin\, cycloheximide and H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003205
name: YGL236C
def: "Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPS1" EXACT []
synonym: "MTO1" EXACT []

[Term]
id: sgd:S000003206
name: YGL237C
def: "Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAP2" EXACT []

[Term]
id: sgd:S000003207
name: YGL238W
def: "Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p \(importin alpha\) back to the cytoplasm after its import substrates have been released into the nucleoplasm\, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSE1" EXACT []
synonym: "KAP109" EXACT []

[Term]
id: sgd:S000003208
name: YGL239C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003209
name: YGL240W
def: "Processivity factor; required for the ubiquitination activity of the anaphase promoting complex \(APC\)\, mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC10" EXACT []
synonym: "DOC1" EXACT []
synonym: "anaphase promoting complex subunit DOC1" EXACT []

[Term]
id: sgd:S000003210
name: YGL241W
def: "Karyopherin\, responsible for nuclear import of specific proteins; cargoes include Spt15p\, Sua7p\, histones H2A and H2B\, and Nap1p; amino terminus shows similarity to those of other importins\, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP114" EXACT []

[Term]
id: sgd:S000003211
name: YGL242C
def: "Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003212
name: YGL243W
def: "tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAD1" EXACT []

[Term]
id: sgd:S000003213
name: YGL244W
def: "Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification\, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on \(GLRO\) assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSL3" EXACT []
synonym: "RTF1" EXACT []

[Term]
id: sgd:S000003214
name: YGL245W
def: "Glutamyl-tRNA synthetase \(GluRS\); forms a complex with methionyl-tRNA synthetase \(Mes1p\) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSN1" EXACT []
synonym: "GUS1" EXACT []
synonym: "GluRS" EXACT []
synonym: "glutamate--tRNA ligase GUS1" EXACT []

[Term]
id: sgd:S000003215
name: YGL246C
def: "Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAI1" EXACT []

[Term]
id: sgd:S000003216
name: YGL247W
def: "Essential nuclear envelope integral membrane protein; required for nuclear envelope morphology\, nuclear pore complex localization\, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRR6" EXACT []

[Term]
id: sgd:S000003217
name: YGL248W
def: "Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling\, target of the cAMP-protein kinase A \(PKA\) pathway; glucose induces transcription and inhibits translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3'" EXACT []
synonym: "5'-cyclic-nucleotide phosphodiesterase PDE1" EXACT []
synonym: "PDE1" EXACT []

[Term]
id: sgd:S000003218
name: YGL249W
def: "Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZIP2" EXACT []

[Term]
id: sgd:S000003219
name: YGL250W
def: "Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMR1" EXACT []

[Term]
id: sgd:S000003220
name: YGL251C
def: "Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HFM1" EXACT []
synonym: "MER3" EXACT []

[Term]
id: sgd:S000003221
name: YGL252C
def: "Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p\, transcriptional activators of the retrograde \(RTG\) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTG2" EXACT []

[Term]
id: sgd:S000003222
name: YGL253W
def: "Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog\, HXK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEX1" EXACT []
synonym: "HKB" EXACT []
synonym: "HXK2" EXACT []
synonym: "SCI2" EXACT []
synonym: "hexokinase 2" EXACT []

[Term]
id: sgd:S000003223
name: YGL254W
def: "Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1\, contains five zinc fingers; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FZF1" EXACT []
synonym: "NRC299" EXACT []
synonym: "RSU1" EXACT []
synonym: "SUL1" EXACT []

[Term]
id: sgd:S000003224
name: YGL255W
def: "High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZRT1" EXACT []
synonym: "high-affinity Zn(2+) transporter ZRT1" EXACT []

[Term]
id: sgd:S000003225
name: YGL256W
def: "Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH4" EXACT []
synonym: "NRC465" EXACT []
synonym: "ZRG5" EXACT []
synonym: "alcohol dehydrogenase ADH4" EXACT []

[Term]
id: sgd:S000003226
name: YGL257C
def: "Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNT2" EXACT []

[Term]
id: sgd:S000003227
name: YGL258W
def: "Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog\, YOR387C\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VEL1" EXACT []

[Term]
id: sgd:S000003228
name: YGL259W
def: "Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPS5" EXACT []

[Term]
id: sgd:S000003229
name: YGL260W
def: "Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003230
name: YGL261C
def: "Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU11" EXACT []
synonym: "seripauperin PAU11" EXACT []

[Term]
id: sgd:S000003231
name: YGL262W
def: "Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003232
name: YGL263W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS12" EXACT []

[Term]
id: sgd:S000003233
name: YGR001C
def: "S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A \(Tef1p/Tef2p\) at lysine 79; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AML1" EXACT []
synonym: "EFM5" EXACT []

[Term]
id: sgd:S000003234
name: YGR002C
def: "Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF2" EXACT []
synonym: "GOD1" EXACT []
synonym: "SWC4" EXACT []

[Term]
id: sgd:S000003235
name: YGR003W
def: "Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUL3" EXACT []
synonym: "CULB" EXACT []
synonym: "CULLIN B" EXACT []
synonym: "cullin CUL3" EXACT []

[Term]
id: sgd:S000003236
name: YGR004W
def: "Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog\, PEX30\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX31" EXACT []

[Term]
id: sgd:S000003237
name: YGR005C
def: "TFIIF \(Transcription Factor II\) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFG2" EXACT []
synonym: "transcription factor IIF subunit TFG2" EXACT []

[Term]
id: sgd:S000003238
name: YGR006W
def: "Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP18" EXACT []

[Term]
id: sgd:S000003239
name: YGR007W
def: "Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP\: phosphocholine cytidylyl-transferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECT1" EXACT []
synonym: "MUQ1" EXACT []
synonym: "ethanolamine-phosphate cytidylyltransferase" EXACT []

[Term]
id: sgd:S000003240
name: YGR008C
def: "Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties\, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog\, TMA10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STF2" EXACT []

[Term]
id: sgd:S000003241
name: YGR009C
def: "t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSS7" EXACT []
synonym: "SEC9" EXACT []

[Term]
id: sgd:S000003242
name: YGR010W
def: "Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD\(+\); homolog of human NMNAT; NMA2 has a paralog\, NMA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NMA2" EXACT []
synonym: "nicotinamide-nucleotide adenylyltransferase NMA2" EXACT []

[Term]
id: sgd:S000003243
name: YGR011W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003244
name: YGR012W
def: "Putative cysteine synthase; localized to the mitochondrial outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative cysteine synthase" EXACT []

[Term]
id: sgd:S000003245
name: YGR013W
def: "Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific\, no metazoan counterpart" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNU71" EXACT []

[Term]
id: sgd:S000003246
name: YGR014W
def: "Mucin family member involved in various signaling pathways; functions as osmosensor in Sho1p-mediated HOG pathway with Msb2p; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSB2" EXACT []

[Term]
id: sgd:S000003247
name: YGR015C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003248
name: YGR016W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003249
name: YGR017W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the nucleus and the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003250
name: YGR018C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003251
name: YGR019W
def: "Gamma-aminobutyrate \(GABA\) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4-aminobutyrate transaminase" EXACT []
synonym: "UGA1" EXACT []

[Term]
id: sgd:S000003252
name: YGR020C
def: "Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase \(V-ATPase\) has eight subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V1 sector ATPase subunit F" EXACT []
synonym: "VMA7" EXACT []

[Term]
id: sgd:S000003253
name: YGR021W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAH1" EXACT []

[Term]
id: sgd:S000003254
name: YGR022C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003255
name: YGR023W
def: "Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog\, MID2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTL1" EXACT []

[Term]
id: sgd:S000003256
name: YGR024C
def: "tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse \(3'-5'\) polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THG1" EXACT []

[Term]
id: sgd:S000003257
name: YGR025W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003258
name: YGR026W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003259
name: YGR027C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S25\, no bacterial homolog; RPS25A has a paralog\, RPS25B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS25A" EXACT []
synonym: "RPS31A" EXACT []
synonym: "S25A" EXACT []
synonym: "S25e" EXACT []
synonym: "S31A" EXACT []
synonym: "YS23" EXACT []
synonym: "ribosomal 40S subunit protein S25A" EXACT []
synonym: "rp45" EXACT []

[Term]
id: sgd:S000003260
name: YGR028W
def: "Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins\, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSP1" EXACT []
synonym: "YTA4" EXACT []

[Term]
id: sgd:S000003261
name: YGR029W
def: "Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria\, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER \(ALR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV1" EXACT []

[Term]
id: sgd:S000003262
name: YGR030C
def: "Subunit of both RNase MRP and nuclear RNase P; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP6" EXACT []

[Term]
id: sgd:S000003263
name: YGR031W
def: "Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMO32" EXACT []

[Term]
id: sgd:S000003264
name: YGR032W
def: "Catalytic subunit of 1\,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog\, FKS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1" EXACT []
synonym: "3-beta-glucan synthase GSC2" EXACT []
synonym: "FKS2" EXACT []
synonym: "GSC2" EXACT []

[Term]
id: sgd:S000003265
name: YGR033C
def: "Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane \(TOM complex\) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane \(TIM23 complex\) activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP17" EXACT []
synonym: "TIM21" EXACT []

[Term]
id: sgd:S000003266
name: YGR034W
def: "Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog\, RPL26A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L24" EXACT []
synonym: "L26B" EXACT []
synonym: "L33B" EXACT []
synonym: "RPL26B" EXACT []
synonym: "YL33" EXACT []
synonym: "ribosomal 60S subunit protein L26B" EXACT []

[Term]
id: sgd:S000003267
name: YGR035C
def: "Putative protein of unknown function\, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog\, YLR346C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003268
name: YGR036C
def: "Dolichyl pyrophosphate \(Dol-P-P\) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAX4" EXACT []
synonym: "CWH8" EXACT []

[Term]
id: sgd:S000003269
name: YGR037C
def: "Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase \(Fas1p-Fas2p\) to acyl-CoA-consuming processes; subject to starvation-induced\, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACB1" EXACT []
synonym: "long-chain fatty acid transporter ACB1" EXACT []

[Term]
id: sgd:S000003270
name: YGR038W
def: "Protein that mediates sphingolipid homeostasis; evolutionarily conserved\, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog\, ORM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORM1" EXACT []

[Term]
id: sgd:S000003271
name: YGR039W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003272
name: YGR040W
def: "Mitogen-activated protein kinase \(MAPK\); involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KSS1" EXACT []
synonym: "mitogen-activated serine/threonine-protein kinase KSS1" EXACT []

[Term]
id: sgd:S000003273
name: YGR041W
def: "Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern\, and bud at the distal pole; BUD9 has a paralog\, BUD8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD9" EXACT []

[Term]
id: sgd:S000003274
name: YGR042W
def: "Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003275
name: YGR043C
def: "Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog\, TAL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NQM1" EXACT []
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1" EXACT []

[Term]
id: sgd:S000003276
name: YGR044C
def: "Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSP1" EXACT []
synonym: "RME1" EXACT []

[Term]
id: sgd:S000003277
name: YGR045C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003278
name: YGR046W
def: "Mitochondrial phosphatidate cytidylyltransferase \(CDP-DAG synthase\); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import\, likely due to altered membrane lipid composition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMP37" EXACT []
synonym: "TAM41" EXACT []

[Term]
id: sgd:S000003279
name: YGR047C
def: "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex \(TFIIIC\); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCF1" EXACT []
synonym: "TFC4" EXACT []
synonym: "tau 131" EXACT []
synonym: "transcription factor TFIIIC subunit TFC4" EXACT []

[Term]
id: sgd:S000003280
name: YGR048W
def: "Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded\, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase \(Hmg1/2p\) and cytoplasmic proteins \(Fbp1p\); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing \(RUP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UFD1" EXACT []
synonym: "polyubiquitin-binding protein UFD1" EXACT []

[Term]
id: sgd:S000003281
name: YGR049W
def: "Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog\, ATG33\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCM4" EXACT []

[Term]
id: sgd:S000003282
name: YGR050C
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003283
name: YGR051C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YGR051C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003284
name: YGR052W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP48" EXACT []
synonym: "protein kinase FMP48" EXACT []

[Term]
id: sgd:S000003285
name: YGR053C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003286
name: YGR054W
def: "Eukaryotic initiation factor \(eIF\) 2A; associates specifically with both 40S subunits and 80 S ribosomes\, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003287
name: YGR055W
def: "High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUP1" EXACT []

[Term]
id: sgd:S000003288
name: YGR056W
def: "Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains\, a bromo-adjacent homology \(BAH\) domain\, and an AT hook; RSC1 has a paralog\, RSC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC subunit protein RSC1" EXACT []
synonym: "RSC1" EXACT []

[Term]
id: sgd:S000003289
name: YGR057C
def: "Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LST7" EXACT []

[Term]
id: sgd:S000003290
name: YGR058W
def: "Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1\, bud neck in G2; binds to Sec31p and modulates COPII coat assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEF1" EXACT []

[Term]
id: sgd:S000003291
name: YGR059W
def: "Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPR3" EXACT []
synonym: "septin SPR3" EXACT []

[Term]
id: sgd:S000003292
name: YGR060W
def: "C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4\,4-dimethylzymosterol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG25" EXACT []
synonym: "methylsterol monooxygenase" EXACT []

[Term]
id: sgd:S000003293
name: YGR061C
def: "Formylglycinamidine-ribonucleotide \(FGAM\)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE6" EXACT []
synonym: "phosphoribosylformylglycinamidine synthase" EXACT []

[Term]
id: sgd:S000003294
name: YGR062C
def: "Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1\, N. crassa Oxa2p\, and E. coli YidC" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX18" EXACT []
synonym: "OXA2" EXACT []

[Term]
id: sgd:S000003295
name: YGR063C
def: "Component of the universally conserved Spt4/5 complex \(DSIF complex\); the complex has multiple roles in concert with RNA polymerases I and II\, including regulation of transcription elongation\, RNA processing\, quality control\, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPT4" EXACT []
synonym: "transcription elongation factor SPT4" EXACT []

[Term]
id: sgd:S000003296
name: YGR064W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003297
name: YGR065C
def: "High-affinity plasma membrane H+-biotin \(vitamin H\) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHT1" EXACT []

[Term]
id: sgd:S000003298
name: YGR066C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003299
name: YGR067C
def: "Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003300
name: YGR068C
def: "Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART5" EXACT []

[Term]
id: sgd:S000003301
name: YGR069W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003302
name: YGR070W
def: "GDP/GTP exchange protein \(GEP\) for Rho1p; mutations are synthetically lethal with mutations in rom2\, which also encodes a GEP; ROM1 has a paralog\, ROM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROM1" EXACT []
synonym: "Rho family guanine nucleotide exchange factor ROM1" EXACT []
synonym: "SKC1" EXACT []

[Term]
id: sgd:S000003303
name: YGR071C
def: "Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; ENV11 has a paralog\, VID22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV11" EXACT []

[Term]
id: sgd:S000003304
name: YGR072W
def: "Component of the nonsense-mediated mRNA decay \(NMD\) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUA6" EXACT []
synonym: "SUP112" EXACT []
synonym: "UPF3" EXACT []

[Term]
id: sgd:S000003305
name: YGR073C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; extensively overlaps essential SMD1 gene encoding a U6 snRNP protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003306
name: YGR074W
def: "Core Sm protein Sm D1; part of heteroheptameric complex \(with Smb1p\, Smd2p\, Smd3p\, Sme1p\, Smx3p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMD1" EXACT []
synonym: "SPP92" EXACT []

[Term]
id: sgd:S000003307
name: YGR075C
def: "Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP38" EXACT []

[Term]
id: sgd:S000003308
name: YGR076C
def: "Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFO1" EXACT []
synonym: "MRPL25" EXACT []
synonym: "YMR26" EXACT []
synonym: "YmL25" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL25" EXACT []

[Term]
id: sgd:S000003309
name: YGR077C
def: "Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex\, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p\, and PTS2-signal receptor Pex7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS6" EXACT []
synonym: "PEX8" EXACT []

[Term]
id: sgd:S000003310
name: YGR078C
def: "Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM2" EXACT []
synonym: "PAC10" EXACT []
synonym: "PFD3" EXACT []
synonym: "RKS2" EXACT []

[Term]
id: sgd:S000003311
name: YGR079W
def: "Putative protein of unknown function; YGR079W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003312
name: YGR080W
def: "Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions\, localizes actin monomers to sites of rapid filament assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TWF1" EXACT []

[Term]
id: sgd:S000003313
name: YGR081C
def: "Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLX9" EXACT []

[Term]
id: sgd:S000003314
name: YGR082W
def: "Component of the TOM \(translocase of outer membrane\) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS20" EXACT []
synonym: "MOM19" EXACT []
synonym: "TOM20" EXACT []

[Term]
id: sgd:S000003315
name: YGR083C
def: "Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD12" EXACT []
synonym: "GCD2" EXACT []

[Term]
id: sgd:S000003316
name: YGR084C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP13" EXACT []
synonym: "mitochondrial 37S ribosomal protein YmS-A" EXACT []

[Term]
id: sgd:S000003317
name: YGR085C
def: "Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog\, RPL11A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L11B" EXACT []
synonym: "L16A" EXACT []
synonym: "L5" EXACT []
synonym: "RPL11B" EXACT []
synonym: "YL22" EXACT []
synonym: "ribosomal 60S subunit protein L11B" EXACT []
synonym: "rp39B" EXACT []

[Term]
id: sgd:S000003318
name: YGR086C
def: "Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIL1" EXACT []
synonym: "lipid-binding protein PIL1" EXACT []

[Term]
id: sgd:S000003319
name: YGR087C
def: "Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde\, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent\, and is strongly induced during sulfur limitation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDC6" EXACT []
synonym: "indolepyruvate decarboxylase 6" EXACT []

[Term]
id: sgd:S000003320
name: YGR088W
def: "Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTT1" EXACT []
synonym: "SPS101" EXACT []
synonym: "catalase T" EXACT []

[Term]
id: sgd:S000003321
name: YGR089W
def: "Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I\, II\, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NNF2" EXACT []

[Term]
id: sgd:S000003322
name: YGR090W
def: "Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP22" EXACT []

[Term]
id: sgd:S000003323
name: YGR091W
def: "Splicing factor; component of the U4/U6-U5 snRNP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP31" EXACT []

[Term]
id: sgd:S000003324
name: YGR092W
def: "Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog\, DBF20\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBF2" EXACT []
synonym: "serine/threonine-protein kinase DBF2" EXACT []

[Term]
id: sgd:S000003325
name: YGR093W
def: "Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus\, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRN1" EXACT []

[Term]
id: sgd:S000003326
name: YGR094W
def: "Mitochondrial and cytoplasmic valyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAS1" EXACT []
synonym: "valine--tRNA ligase" EXACT []

[Term]
id: sgd:S000003327
name: YGR095C
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p \(EXOSC5\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP46" EXACT []

[Term]
id: sgd:S000003328
name: YGR096W
def: "Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate \(ThPP\) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPC1" EXACT []

[Term]
id: sgd:S000003329
name: YGR097W
def: "Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog\, RGC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASK10" EXACT []
synonym: "RGC2" EXACT []

[Term]
id: sgd:S000003330
name: YGR098C
def: "Separase\, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESP1" EXACT []

[Term]
id: sgd:S000003331
name: YGR099W
def: "Subunit of the ASTRA complex\, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats\, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TEL2" EXACT []

[Term]
id: sgd:S000003332
name: YGR100W
def: "Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p\, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP2" EXACT []
synonym: "MDR1" EXACT []
synonym: "MIC1" EXACT []

[Term]
id: sgd:S000003333
name: YGR101W
def: "Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM37" EXACT []
synonym: "PCP1" EXACT []
synonym: "RBD1" EXACT []

[Term]
id: sgd:S000003334
name: YGR102C
def: "Subunit of the trimeric GatFAB AmidoTransferase\(AdT\) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTF1" EXACT []
synonym: "glutamyl-tRNA(Gln) amidotransferase subunit F" EXACT []

[Term]
id: sgd:S000003335
name: YGR103W
def: "Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP7" EXACT []
synonym: "YPH1" EXACT []

[Term]
id: sgd:S000003336
name: YGR104C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED18" EXACT []
synonym: "SRB5" EXACT []

[Term]
id: sgd:S000003337
name: YGR105W
def: "Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase \(V-ATPase\) complex; diverged ortholog of human XMEA \(X-linked Myopathy with Excessive Autophagy\); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum \(ER\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VMA21" EXACT []

[Term]
id: sgd:S000003338
name: YGR106C
def: "ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase \(V-ATPase\) deficiency of a vma21 mutant impaired in endoplasmic reticulum \(ER\) retrieval" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VOA1" EXACT []

[Term]
id: sgd:S000003339
name: YGR107W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003340
name: YGR108W
def: "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M\, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog\, CLB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB1" EXACT []
synonym: "CLB1" EXACT []
synonym: "SCB1" EXACT []

[Term]
id: sgd:S000003341
name: YGR109C
def: "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog\, CLB5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB6" EXACT []
synonym: "CLB6" EXACT []

[Term]
id: sgd:S000003342
name: YGR110W
def: "Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLD1" EXACT []

[Term]
id: sgd:S000003343
name: YGR111W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003344
name: YGR112W
def: "Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHY1" EXACT []

[Term]
id: sgd:S000003345
name: YGR113W
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); cooperates with Duo1p to connect the DASH complex with the microtubules \(MT\); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAM1" EXACT []

[Term]
id: sgd:S000003346
name: YGR114C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003347
name: YGR115C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003348
name: YGR116W
def: "Nucleosome remodeling protein; functions in various aspects of transcription\, chromatin maintenance\, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region; required for H3K36 trimethylation but not dimethylation by Set2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRE2" EXACT []
synonym: "SPT6" EXACT []
synonym: "SSN20" EXACT []
synonym: "chromatin-remodeling histone chaperone SPT6" EXACT []

[Term]
id: sgd:S000003349
name: YGR117C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003350
name: YGR118W
def: "Ribosomal protein 28 \(rp28\) of the small \(40S\) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog\, RPS23B\, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS23A" EXACT []
synonym: "S12" EXACT []
synonym: "S23A" EXACT []
synonym: "S28A" EXACT []
synonym: "YS14" EXACT []
synonym: "ribosomal 40S subunit protein S23A" EXACT []
synonym: "rp37" EXACT []

[Term]
id: sgd:S000003351
name: YGR119C
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex \(NPC\) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins \(Nsp1p and Nup49p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP57" EXACT []
synonym: "NUP57" EXACT []

[Term]
id: sgd:S000003352
name: YGR120C
def: "Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COG2" EXACT []
synonym: "SEC35" EXACT []

[Term]
id: sgd:S000003353
name: YGR121C
def: "Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium \(NH4+\); expression is under the nitrogen catabolite repression regulation; MEP1 has a paralog\, MEP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMT1" EXACT []
synonym: "MEP1" EXACT []
synonym: "ammonium permease MEP1" EXACT []

[Term]
id: sgd:S000003354
name: YGR122W
def: "Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC\, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003355
name: YGR123C
def: "Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPT1" EXACT []

[Term]
id: sgd:S000003356
name: YGR124W
def: "Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog\, ASN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASN2" EXACT []
synonym: "asparagine synthase (glutamine-hydrolyzing) 2" EXACT []

[Term]
id: sgd:S000003357
name: YGR125W
def: "Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003358
name: YGR126W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003359
name: YGR127W
def: "Putative protein of unknown function; expression is regulated by Msn2p/Msn4p\, indicating a possible role in stress response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003360
name: YGR128C
def: "Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP8" EXACT []

[Term]
id: sgd:S000003361
name: YGR129W
def: "Member of the NineTeen Complex \(NTC\); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTC31" EXACT []
synonym: "SYF2" EXACT []

[Term]
id: sgd:S000003362
name: YGR130C
def: "Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate \(IP7\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003363
name: YGR131W
def: "Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif\, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog\, NCE102\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FHN1" EXACT []

[Term]
id: sgd:S000003364
name: YGR132C
def: "Subunit of the prohibitin complex \(Phb1p-Phb2p\); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response \(mtUPR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHB1" EXACT []
synonym: "prohibitin subunit PHB1" EXACT []

[Term]
id: sgd:S000003365
name: YGR133W
def: "Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E2 ubiquitin-protein ligase peroxin 4" EXACT []
synonym: "PAS2" EXACT []
synonym: "PEX4" EXACT []
synonym: "UBC10" EXACT []

[Term]
id: sgd:S000003366
name: YGR134W
def: "Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation\, elongation\, and degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF130" EXACT []
synonym: "CCR4-NOT core subunit CAF130" EXACT []

[Term]
id: sgd:S000003367
name: YGR135W
def: "Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit \(Pre6p\) under stress conditions to create a more active proteasomal isoform" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE9" EXACT []
synonym: "proteasome core particle subunit alpha 3" EXACT []

[Term]
id: sgd:S000003368
name: YGR136W
def: "Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p\, a homolog of human Wiskott-Aldrich Syndrome protein \(WASP\)\, via an N-terminal SH3 domain\, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog\, PIN3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSB1" EXACT []

[Term]
id: sgd:S000003369
name: YGR137W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003370
name: YGR138C
def: "Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog\, TPO3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPO2" EXACT []

[Term]
id: sgd:S000003371
name: YGR139W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003372
name: YGR140W
def: "Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex\, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF2" EXACT []
synonym: "CBF3A" EXACT []
synonym: "CEP2" EXACT []
synonym: "CSL5" EXACT []
synonym: "CTF14" EXACT []
synonym: "NDC10" EXACT []

[Term]
id: sgd:S000003373
name: YGR141W
def: "Vacuolar protein sorting \(VPS\) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog\, TDA6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS62" EXACT []

[Term]
id: sgd:S000003374
name: YGR142W
def: "v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake\, possible role in mediating pH homeostasis between the vacuole and plasma membrane H\(+\)-ATPase; contributes to prion curing; BTN2 has a paralog\, CUR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTN2" EXACT []

[Term]
id: sgd:S000003375
name: YGR143W
def: "Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog\, KRE6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKN1" EXACT []
synonym: "beta-glucan synthesis-associated protein SKN1" EXACT []

[Term]
id: sgd:S000003376
name: YGR144W
def: "Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESP35" EXACT []
synonym: "MOL1" EXACT []
synonym: "THI4" EXACT []
synonym: "thiamine thiazole synthase" EXACT []

[Term]
id: sgd:S000003377
name: YGR145W
def: "Component of the SSU; required for pre-18S rRNA processing\, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA\, Mpp10p and Bfr2p; contains WD repeats\, and has homology to Spb1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENP2" EXACT []

[Term]
id: sgd:S000003378
name: YGR146C
def: "Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECL1" EXACT []

[Term]
id: sgd:S000003379
name: YGR147C
def: "Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAT2" EXACT []

[Term]
id: sgd:S000003380
name: YGR148C
def: "Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24\, no bacterial homolog; RPL24B has a paralog\, RPL24A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L24B" EXACT []
synonym: "L24e" EXACT []
synonym: "L30B" EXACT []
synonym: "RPL24B" EXACT []
synonym: "RPL30B" EXACT []
synonym: "YL21" EXACT []
synonym: "ribosomal 60S subunit protein L24B" EXACT []
synonym: "rp29" EXACT []

[Term]
id: sgd:S000003381
name: YGR149W
def: "Putative protein of unknown function; predicted to be an integal membrane protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003382
name: YGR150C
def: "Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat \(PPR\) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCM1" EXACT []
synonym: "DMR1" EXACT []
synonym: "RRG2" EXACT []

[Term]
id: sgd:S000003383
name: YGR151C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003384
name: YGR152C
def: "GTP-binding protein of the Ras superfamily; required for bud site selection\, morphological changes in response to mating pheromone\, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD1" EXACT []
synonym: "RSR1" EXACT []
synonym: "Ras family GTPase RSR1" EXACT []

[Term]
id: sgd:S000003385
name: YGR153W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS10" EXACT []

[Term]
id: sgd:S000003386
name: YGR154C
def: "Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTO1" EXACT []

[Term]
id: sgd:S000003387
name: YGR155W
def: "Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine\, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity\, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYS4" EXACT []
synonym: "NHS5" EXACT []
synonym: "STR4" EXACT []
synonym: "VMA41" EXACT []
synonym: "cystathionine beta-synthase CYS4" EXACT []

[Term]
id: sgd:S000003388
name: YGR156W
def: "Essential component of CPF \(cleavage and polyadenylation factor\); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTI1" EXACT []

[Term]
id: sgd:S000003389
name: YGR157W
def: "Phosphatidylethanolamine methyltransferase \(PEMT\); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHO2" EXACT []
synonym: "PEM1" EXACT []
synonym: "phosphatidylethanolamine N-methyltransferase" EXACT []

[Term]
id: sgd:S000003390
name: YGR158C
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p \(EXOSC6\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTR3" EXACT []

[Term]
id: sgd:S000003391
name: YGR159C
def: "Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSR1" EXACT []
synonym: "SHE5" EXACT []

[Term]
id: sgd:S000003392
name: YGR160W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003393
name: YGR161C
def: "Putative component of the protein phosphatase type 2A complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTS3" EXACT []

[Term]
id: sgd:S000003394
name: YGR162W
def: "Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex \(eIF4F\) that also contains eIF4E \(Cdc33p\); interacts with Pab1p and with eIF4A \(Tif1p\); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog\, TIF4632\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF4631" EXACT []
synonym: "eiF4G1" EXACT []

[Term]
id: sgd:S000003395
name: YGR163W
def: "Putative GTP binding protein; negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTR2" EXACT []

[Term]
id: sgd:S000003396
name: YGR164W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003397
name: YGR165W
def: "Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol\, is sensitive to 2\,4-dichlorophenol\, and accumulates large lipid droplets" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS35" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS35" EXACT []

[Term]
id: sgd:S000003398
name: YGR166W
def: "Component of transport protein particle \(TRAPP\) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE11" EXACT []
synonym: "TRS65" EXACT []

[Term]
id: sgd:S000003399
name: YGR167W
def: "Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLC1" EXACT []
synonym: "SCD4" EXACT []

[Term]
id: sgd:S000003400
name: YGR168C
def: "Putative protein of unknown function; YGR168C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003401
name: YGR169C
def: "tRNA\:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS6" EXACT []
synonym: "pseudouridine synthase PUS6" EXACT []

[Term]
id: sgd:S000003402
name: YGR170W
def: "Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSD2" EXACT []
synonym: "phosphatidylserine decarboxylase 2" EXACT []

[Term]
id: sgd:S000003403
name: YGR171C
def: "Mitochondrial methionyl-tRNA synthetase \(MetRS\); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSM1" EXACT []
synonym: "methionine--tRNA ligase MSM1" EXACT []

[Term]
id: sgd:S000003404
name: YGR172C
def: "Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi\, the ER\, and COPII vesicles; homolog of human YIPF4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIP1" EXACT []

[Term]
id: sgd:S000003405
name: YGR173W
def: "Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIR1" EXACT []
synonym: "RBG2" EXACT []

[Term]
id: sgd:S000003406
name: YGR174C
def: "Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b \(Cobp\) to promote assembly of Cobp into the cytochrome bc1 complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP4" EXACT []

[Term]
id: sgd:S000003407
name: YGR175C
def: "Squalene epoxidase; catalyzes the epoxidation of squalene to 2\,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG1" EXACT []
synonym: "squalene monooxygenase" EXACT []

[Term]
id: sgd:S000003408
name: YGR176W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003409
name: YGR177C
def: "Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation\, which is important for brewing and winemaking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATF2" EXACT []

[Term]
id: sgd:S000003410
name: YGR178C
def: "Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS16" EXACT []
synonym: "PBP1" EXACT []

[Term]
id: sgd:S000003411
name: YGR179C
def: "Outer kinetochore protein required for accurate chromosome segregation; component of COMA \(Ctf19p\, Okp1p\, Mcm21p\, Ame1p\) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-Q and fission yeast fta7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OKP1" EXACT []

[Term]
id: sgd:S000003412
name: YGR180C
def: "Ribonucleotide-diphosphate reductase \(RNR\) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog\, RNR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT3" EXACT []
synonym: "PSO3" EXACT []
synonym: "RNR4" EXACT []
synonym: "ribonucleotide-diphosphate reductase subunit RNR4" EXACT []

[Term]
id: sgd:S000003413
name: YGR181W
def: "Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM13" EXACT []

[Term]
id: sgd:S000003414
name: YGR182C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003415
name: YGR183C
def: "Subunit 9 of ubiquinol cytochrome-c reductase \(Complex III\); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QCR9" EXACT []
synonym: "UCR9" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 9" EXACT []

[Term]
id: sgd:S000003416
name: YGR184C
def: "E3 ubiquitin ligase \(N-recognin\); heterodimerizes with Rad6p to ubiquitinate substrates in the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation \(ERAD\) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome \(JBS\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase UBR1" EXACT []
synonym: "PTR1" EXACT []
synonym: "UBR1" EXACT []

[Term]
id: sgd:S000003417
name: YGR185C
def: "Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth \(CMT\) neuropathies; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TTS1" EXACT []
synonym: "TYS1" EXACT []
synonym: "TyrRS" EXACT []
synonym: "tyrosine--tRNA ligase TYS1" EXACT []

[Term]
id: sgd:S000003418
name: YGR186W
def: "TFIIF \(Transcription Factor II\) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAP74" EXACT []
synonym: "SSU71" EXACT []
synonym: "TFG1" EXACT []
synonym: "transcription factor IIF subunit TFG1" EXACT []

[Term]
id: sgd:S000003419
name: YGR187C
def: "Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 \(Brain protein 16\); relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HGH1" EXACT []

[Term]
id: sgd:S000003420
name: YGR188C
def: "Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p\, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUB1" EXACT []
synonym: "protein kinase BUB1" EXACT []

[Term]
id: sgd:S000003421
name: YGR189C
def: "Chitin transglycosylase; functions in the transfer of chitin to beta\(1-6\) and beta\(1-3\) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRH1" EXACT []

[Term]
id: sgd:S000003422
name: YGR190C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003423
name: YGR191W
def: "High-affinity histidine permease; also involved in the transport of manganese ions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIP1" EXACT []
synonym: "histidine permease" EXACT []

[Term]
id: sgd:S000003424
name: YGR192C
def: "Glyceraldehyde-3-phosphate dehydrogenase \(GAPDH\)\, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1\,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria; binds AU-rich RNA; TDH3 has a paralog\, TDH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAPDH" EXACT []
synonym: "GLD1" EXACT []
synonym: "GPD" EXACT []
synonym: "HSP35" EXACT []
synonym: "HSP36" EXACT []
synonym: "SSS2" EXACT []
synonym: "TDH3" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3" EXACT []

[Term]
id: sgd:S000003425
name: YGR193C
def: "E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase \(E3\) to the dihydrolipoamide acetyltransferase \(E2\) core" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDX1" EXACT []

[Term]
id: sgd:S000003426
name: YGR194C
def: "Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "XKS1" EXACT []
synonym: "xylulokinase" EXACT []

[Term]
id: sgd:S000003427
name: YGR195W
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p \(EXOSC4\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM20" EXACT []
synonym: "RRP41" EXACT []
synonym: "SKI6" EXACT []

[Term]
id: sgd:S000003428
name: YGR196C
def: "Protein of unknown function; required for survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV8" EXACT []

[Term]
id: sgd:S000003429
name: YGR197C
def: "Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog\, YJR015W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNG1" EXACT []

[Term]
id: sgd:S000003430
name: YGR198W
def: "Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required\, along with Efr3p\, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase \(PIK\) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPP1" EXACT []

[Term]
id: sgd:S000003431
name: YGR199W
def: "Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT6" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase PMT6" EXACT []

[Term]
id: sgd:S000003432
name: YGR200C
def: "Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP2" EXACT []
synonym: "Elongator subunit ELP2" EXACT []
synonym: "KTI3" EXACT []
synonym: "TOT2" EXACT []

[Term]
id: sgd:S000003433
name: YGR201C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003434
name: YGR202C
def: "Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis\, inhibited by Sec14p\, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSR2" EXACT []
synonym: "CCT1" EXACT []
synonym: "PCT1" EXACT []
synonym: "choline-phosphate cytidylyltransferase" EXACT []

[Term]
id: sgd:S000003435
name: YGR203W
def: "Phosphatase with sequence similarity to Cdc25p; Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCH1" EXACT []

[Term]
id: sgd:S000003436
name: YGR204W
def: "Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines\, thymidylate\, methionine\, and histidine; null mutation causes auxotrophy for adenine and histidine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE3" EXACT []
synonym: "trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3" EXACT []

[Term]
id: sgd:S000003437
name: YGR205W
def: "ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA10" EXACT []

[Term]
id: sgd:S000003438
name: YGR206W
def: "ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex \(Stp22p\, Vps28p\, Srn2p\) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MVB12" EXACT []
synonym: "ubiquitin-binding ESCRT-I subunit protein MVB12" EXACT []

[Term]
id: sgd:S000003439
name: YGR207C
def: "Mitochondrial protein that interacts with frataxin \(Yfh1p\); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIR1" EXACT []

[Term]
id: sgd:S000003440
name: YGR208W
def: "Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis\, expression is regulated by the available nitrogen source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SER2" EXACT []
synonym: "phosphoserine phosphatase" EXACT []

[Term]
id: sgd:S000003441
name: YGR209C
def: "Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p\, facilitates mitochondrial import of small Tims Tim9p\, Tim10p\, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog\, TRX1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LMA1" EXACT []
synonym: "TRX2" EXACT []
synonym: "thioredoxin TRX2" EXACT []

[Term]
id: sgd:S000003442
name: YGR210C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003443
name: YGR211W
def: "Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 \(Tef1p\); relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZPR1" EXACT []

[Term]
id: sgd:S000003444
name: YGR212W
def: "N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin \(ISP-1\) by converting it into N-acetyl-myriocin\, co-operates with Ypk1p in mediating resistance to myriocin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLI1" EXACT []

[Term]
id: sgd:S000003445
name: YGR213C
def: "Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter \(LTE\) family of protein; RTA1 has a paralog\, YLR046C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTA1" EXACT []

[Term]
id: sgd:S000003446
name: YGR214W
def: "Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate\, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog\, RPS0B\, that arose from the whole genome duplication;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAB1" EXACT []
synonym: "NAB1A" EXACT []
synonym: "RPS0A" EXACT []
synonym: "S0A" EXACT []
synonym: "S2" EXACT []
synonym: "YST1" EXACT []
synonym: "ribosomal 40S subunit protein S0A" EXACT []

[Term]
id: sgd:S000003447
name: YGR215W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM27" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM27" EXACT []

[Term]
id: sgd:S000003448
name: YGR216C
def: "Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol \(GlcNAc-PI\) is the first intermediate in the synthesis of glycosylphosphatidylinositol \(GPI\) anchors; human and mouse GPI1p are functional homologs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI1" EXACT []

[Term]
id: sgd:S000003449
name: YGR217W
def: "Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however\, evidence suggests CCH1 is not required for Mid1p function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCH1" EXACT []

[Term]
id: sgd:S000003450
name: YGR218W
def: "Major karyopherin; involved in export of proteins\, RNAs\, and ribosomal subunits from the nucleus; exportin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRM1" EXACT []
synonym: "KAP124" EXACT []
synonym: "XPO1" EXACT []
synonym: "exportin CRM1" EXACT []

[Term]
id: sgd:S000003451
name: YGR219W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003452
name: YGR220C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL9" EXACT []
synonym: "YmL9" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL9" EXACT []

[Term]
id: sgd:S000003453
name: YGR221C
def: "Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog\, SKG6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS2" EXACT []

[Term]
id: sgd:S000003454
name: YGR222W
def: "Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET54" EXACT []

[Term]
id: sgd:S000003455
name: YGR223C
def: "Phosphatidylinositol 3\,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSV2" EXACT []

[Term]
id: sgd:S000003456
name: YGR224W
def: "Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AZR1" EXACT []

[Term]
id: sgd:S000003457
name: YGR225W
def: "Activator of meiotic anaphase promoting complex \(APC/C\); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle\, required for DSB induced prophase I arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMA1" EXACT []
synonym: "SPO70" EXACT []

[Term]
id: sgd:S000003458
name: YGR226C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF\, AMA1/YGR225W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003459
name: YGR227W
def: "Dolichyl-phosphoglucose-dependent alpha-1\,2 glucosyltransferase; located in the ER; functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2- glucosyltransferase" EXACT []
synonym: "ALG10" EXACT []
synonym: "DIE2" EXACT []
synonym: "dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000003460
name: YGR228W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003461
name: YGR229C
def: "Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KNR4" EXACT []
synonym: "SMI1" EXACT []

[Term]
id: sgd:S000003462
name: YGR230W
def: "Protein of unknown function; overexpression bypasses need for Spo12p\, but not required for meiosis; BNS1 has a paralog\, SPO12\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNS1" EXACT []

[Term]
id: sgd:S000003463
name: YGR231C
def: "Subunit of the prohibitin complex \(Phb1p-Phb2p\); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response \(mtUPR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHB2" EXACT []
synonym: "prohibitin subunit PHB2" EXACT []

[Term]
id: sgd:S000003464
name: YGR232W
def: "Assembly chaperone for the 19S proteasome regulatory particle base; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle \(RP\); ortholog of human oncoprotein gankyrin\, which interacts with the Rb tumor suppressor and CDK4/6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAS6" EXACT []

[Term]
id: sgd:S000003465
name: YGR233C
def: "Cyclin-dependent kinase \(CDK\) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate \(IP7\) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO81" EXACT []
synonym: "VAC6" EXACT []
synonym: "phoS" EXACT []

[Term]
id: sgd:S000003466
name: YGR234W
def: "Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YHB1" EXACT []
synonym: "YHB4" EXACT []

[Term]
id: sgd:S000003467
name: YGR235C
def: "Component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCS29" EXACT []
synonym: "MIC26" EXACT []
synonym: "MIO27" EXACT []
synonym: "MOS2" EXACT []

[Term]
id: sgd:S000003468
name: YGR236C
def: "Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPG1" EXACT []

[Term]
id: sgd:S000003469
name: YGR237C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003470
name: YGR238C
def: "Protein that negatively regulates mitotic exit; functions in a complex with Kel1p\, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL2 has a paralog\, KEL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEL2" EXACT []

[Term]
id: sgd:S000003471
name: YGR239C
def: "Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress; PEX21 has a paralog\, PEX18\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX21" EXACT []

[Term]
id: sgd:S000003472
name: YGR240C
def: "Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis\, indispensable for anaerobic growth\, activated by fructose-2\,6-bisphosphate and AMP\, mutation inhibits glucose induction of cell cycle-related genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-phosphofructokinase subunit alpha" EXACT []
synonym: "PFK1" EXACT []

[Term]
id: sgd:S000003473
name: YGR241C
def: "Protein of the AP180 family\, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog\, YAP1801\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP1802" EXACT []

[Term]
id: sgd:S000003474
name: YGR242W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003475
name: YGR243W
def: "Highly conserved subunit of mitochondrial pyruvate carrier; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress; MPC3 has a paralog\, MPC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP43" EXACT []
synonym: "MPC3" EXACT []

[Term]
id: sgd:S000003476
name: YGR244C
def: "Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSC2" EXACT []
synonym: "succinate--CoA ligase (GDP-forming) subunit beta" EXACT []

[Term]
id: sgd:S000003477
name: YGR245C
def: "Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDA1" EXACT []

[Term]
id: sgd:S000003478
name: YGR246C
def: "TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB\, binds TFIIIC and TBP and recruits RNA pol III to promoters\, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRF1" EXACT []
synonym: "PCF4" EXACT []
synonym: "TDS4" EXACT []
synonym: "TFIIIB70" EXACT []
synonym: "transcription factor TFIIIB subunit BRF1" EXACT []

[Term]
id: sgd:S000003479
name: YGR247W
def: "Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1''\, 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPD1" EXACT []

[Term]
id: sgd:S000003480
name: YGR248W
def: "6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog\, SOL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-phosphogluconolactonase SOL4" EXACT []
synonym: "SOL4" EXACT []

[Term]
id: sgd:S000003481
name: YGR249W
def: "Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGA1" EXACT []

[Term]
id: sgd:S000003482
name: YGR250C
def: "Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003483
name: YGR251W
def: "Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome\, required for cleavage of pre-rRNA at A0\, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHI1" EXACT []
synonym: "NOP19" EXACT []

[Term]
id: sgd:S000003484
name: YGR252W
def: "Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p\, a subunit of the RSC chromatin-remodeling complex\, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on \(GLRO\) assay; greater involvement in repression of RNAPII-dependent transcription than in activation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAS104" EXACT []
synonym: "ADA4" EXACT []
synonym: "GCN5" EXACT []
synonym: "KAT2" EXACT []
synonym: "SWI9" EXACT []
synonym: "histone acetyltransferase GCN5" EXACT []

[Term]
id: sgd:S000003485
name: YGR253C
def: "Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA5" EXACT []
synonym: "PUP2" EXACT []
synonym: "proteasome core particle subunit alpha 5" EXACT []

[Term]
id: sgd:S000003486
name: YGR254W
def: "Enolase I\, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog\, ENO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENO1" EXACT []
synonym: "HSP48" EXACT []
synonym: "phosphopyruvate hydratase ENO1" EXACT []

[Term]
id: sgd:S000003487
name: YGR255C
def: "Putative flavin-dependent monooxygenase; involved in ubiquinone \(Coenzyme Q\) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome \(SRNS\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ6" EXACT []
synonym: "N-dimethylaniline monooxygenase COQ6" EXACT []
synonym: "putative N" EXACT []

[Term]
id: sgd:S000003488
name: YGR256W
def: "6-phosphogluconate dehydrogenase \(decarboxylating\); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog\, GND1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GND2" EXACT []
synonym: "phosphogluconate dehydrogenase (decarboxylating) GND2" EXACT []

[Term]
id: sgd:S000003489
name: YGR257C
def: "Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5′-phosphate transporter; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTM1" EXACT []

[Term]
id: sgd:S000003490
name: YGR258C
def: "Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 \(NEF3\); homolog of human XPG protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD2" EXACT []
synonym: "ssDNA endodeoxyribonuclease RAD2" EXACT []

[Term]
id: sgd:S000003491
name: YGR259C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003492
name: YGR260W
def: "High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate \(PABA\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TNA1" EXACT []

[Term]
id: sgd:S000003493
name: YGR261C
def: "Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL6" EXACT []
synonym: "YKS5" EXACT []

[Term]
id: sgd:S000003494
name: YGR262C
def: "Protein kinase; component of the EKC/KEOPS complex with Kae1p\, Cgi121p\, Pcc1p\, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD32" EXACT []
synonym: "LDB14" EXACT []
synonym: "serine/threonine protein kinase BUD32" EXACT []

[Term]
id: sgd:S000003495
name: YGR263C
def: "Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum \(ER\) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein \(GFP\)-fusion protein localizes to the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAY1" EXACT []

[Term]
id: sgd:S000003496
name: YGR264C
def: "Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase \(Gus1p\) and Arc1p\, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MES1" EXACT []
synonym: "MESI" EXACT []
synonym: "MetRS" EXACT []
synonym: "methionine--tRNA ligase MES1" EXACT []

[Term]
id: sgd:S000003497
name: YGR265W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C\, which encodes methionyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003498
name: YGR266W
def: "Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003499
name: YGR267C
def: "GTP-cyclohydrolase I; catalyzes the first step in the folic acid biosynthetic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOL2" EXACT []
synonym: "GTP cyclohydrolase I" EXACT []

[Term]
id: sgd:S000003500
name: YGR268C
def: "Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUA1" EXACT []

[Term]
id: sgd:S000003501
name: YGR269W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003502
name: YGR270W
def: "Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3\, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YTA7" EXACT []

[Term]
id: sgd:S000003503
name: YGR271W
def: "Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly\(A\) mRNAs; required for repressing propagation of dsRNA viruses" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLH1" EXACT []

[Term]
id: sgd:S000003505
name: YGR273C
def: "Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog\, YMR295C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IBI1" EXACT []

[Term]
id: sgd:S000003506
name: YGR274C
def: "TFIID subunit\, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAT4" EXACT []
synonym: "TAF1" EXACT []
synonym: "TAF130" EXACT []
synonym: "TAF145" EXACT []
synonym: "TafII130" EXACT []
synonym: "TafII145" EXACT []

[Term]
id: sgd:S000003507
name: YGR275W
def: "Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTT102" EXACT []

[Term]
id: sgd:S000003508
name: YGR276C
def: "3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REX1" EXACT []
synonym: "RNA82" EXACT []
synonym: "RNH70" EXACT []

[Term]
id: sgd:S000003509
name: YGR277C
def: "Subunit of the CoA-Synthesizing Protein Complex \(CoA-SPC\); subunits of this complex are\: Cab2p\, Cab3p\, Cab4p\, Cab5p\, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase \(PPAT\); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD \(encoding PPAT\); widely conserved" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAB4" EXACT []
synonym: "putative pantetheine-phosphate adenylyltransferase" EXACT []

[Term]
id: sgd:S000003510
name: YGR278W
def: "Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC22" EXACT []

[Term]
id: sgd:S000003511
name: YGR279C
def: "Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog\, SCW10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCW4" EXACT []

[Term]
id: sgd:S000003512
name: YGR280C
def: "Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p\, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GNO1" EXACT []
synonym: "PXR1" EXACT []
synonym: "PinX1" EXACT []

[Term]
id: sgd:S000003513
name: YGR281W
def: "Plasma membrane ATP-binding cassette \(ABC\) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor \(CFTR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette transporter YOR1" EXACT []
synonym: "YOR1" EXACT []
synonym: "YRS1" EXACT []

[Term]
id: sgd:S000003514
name: YGR282C
def: "Endo-beta-1\,3-glucanase; major protein of the cell wall\, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BGL2" EXACT []
synonym: "SCW9" EXACT []

[Term]
id: sgd:S000003515
name: YGR283C
def: "Putative methyltransferase; may interact with ribosomes\, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog\, YMR310C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003516
name: YGR284C
def: "Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV29" EXACT []

[Term]
id: sgd:S000003517
name: YGR285C
def: "Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and\, in partnership with Ssz1p and SSb1/2\, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZUO1" EXACT []
synonym: "zuotin" EXACT []

[Term]
id: sgd:S000003518
name: YGR286C
def: "Biotin synthase; catalyzes the conversion of dethiobiotin to biotin\, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIO2" EXACT []
synonym: "biotin synthase" EXACT []

[Term]
id: sgd:S000003519
name: YGR287C
def: "Major isomaltase \(alpha-1\,6-glucosidase/alpha-methylglucosidase\); required for isomaltose utilization; preferred specificity for isomaltose\, alpha-methylglucoside\, and palatinose\, but also exhibits alpha-1\,2 glucosidase activity on sucrose and kojibiose\, and can cleave the 1\,3-alpha linkage of nigerose and turanose and the alpha-1\,5 linkage of leucrose in vitro; member of the IMA isomaltase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase IMA1" EXACT []
synonym: "IMA1" EXACT []
synonym: "oligo-1" EXACT []

[Term]
id: sgd:S000003520
name: YGR288W
def: "MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAL13" EXACT []
synonym: "MALR" EXACT []
synonym: "transcription factor MAL13" EXACT []

[Term]
id: sgd:S000003521
name: YGR289C
def: "High-affinity maltose transporter \(alpha-glucoside transporter\); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGT1" EXACT []
synonym: "MAL11" EXACT []
synonym: "MALT" EXACT []

[Term]
id: sgd:S000003522
name: YGR290W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C \(a high-affinity maltose transporter\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003523
name: YGR291C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003524
name: YGR292W
def: "Maltase \(alpha-D-glucosidase\); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose\, turanose\, maltotriose\, and sucrose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAL12" EXACT []
synonym: "MALS" EXACT []
synonym: "alpha-glucosidase MAL12" EXACT []

[Term]
id: sgd:S000003525
name: YGR293C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003526
name: YGR294W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU12" EXACT []
synonym: "seripauperin PAU12" EXACT []

[Term]
id: sgd:S000003527
name: YGR295C
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS6" EXACT []

[Term]
id: sgd:S000003528
name: YGR296W
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 3" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-3" EXACT []

[Term]
id: sgd:S000003529
name: YHR001W-A
def: "Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp\, Rip1p\, Cyt1p\, Cor1p\, Qcr2p\, Qcr6p\, Qcr7p\, Qcr8p\, Qcr9p\, and Qcr10p and comprises part of the mitochondrial respiratory chain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QCR10" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 10" EXACT []

[Term]
id: sgd:S000003530
name: YHR005C-A
def: "Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p \(TIM10 complex\) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS11" EXACT []
synonym: "TIM10" EXACT []
synonym: "protein transporter TIM10" EXACT []

[Term]
id: sgd:S000003531
name: YHR021W-A
def: "Putative protein of unknown function; may contribute to cell wall biosynthesis\, mutants display zymolyase hypersensitivity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM12" EXACT []

[Term]
id: sgd:S000003532
name: YHR049C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003533
name: YHR139C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003535
name: YHR214W-A
def: "Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog\, YAR068W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003536
name: YIL014C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIL015C-A" EXACT []

[Term]
id: sgd:S000003538
name: YJL001W
def: "Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRL21" EXACT []
synonym: "PRE3" EXACT []
synonym: "proteasome core particle subunit beta 1" EXACT []

[Term]
id: sgd:S000003539
name: YJL002C
def: "Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NLT1" EXACT []
synonym: "OST1" EXACT []

[Term]
id: sgd:S000003540
name: YJL003W
def: "Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX16" EXACT []

[Term]
id: sgd:S000003541
name: YJL004C
def: "Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYS1" EXACT []

[Term]
id: sgd:S000003542
name: YJL005W
def: "Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes\, including metabolism\, cell cycle\, stress response\, stationary phase\, and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC35" EXACT []
synonym: "CYR1" EXACT []
synonym: "FIL1" EXACT []
synonym: "HSR1" EXACT []
synonym: "SRA4" EXACT []
synonym: "TSM0185" EXACT []
synonym: "adenylate cyclase" EXACT []

[Term]
id: sgd:S000003543
name: YJL006C
def: "Beta subunit of C-terminal domain kinase I \(CTDK-I\); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing\, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTK2" EXACT []

[Term]
id: sgd:S000003544
name: YJL007C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003545
name: YJL008C
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCT8" EXACT []

[Term]
id: sgd:S000003546
name: YJL009W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C\, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003547
name: YJL010C
def: "Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP9" EXACT []

[Term]
id: sgd:S000003548
name: YJL011C
def: "RNA polymerase III subunit C17; physically interacts with C31\, C11\, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C17" EXACT []
synonym: "DNA-directed RNA polymerase III subunit RPC17" EXACT []
synonym: "RPC17" EXACT []

[Term]
id: sgd:S000003549
name: YJL012C
def: "Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone \(VTC\) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM3" EXACT []
synonym: "VTC4" EXACT []
synonym: "YJL012C-A" EXACT []

[Term]
id: sgd:S000003550
name: YJL013C
def: "Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC\(Cdc20\)\, the anaphase promoting complex involved in securin \(Pds1p\) turnover; MAD3 has a paralog\, BUB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAD3" EXACT []

[Term]
id: sgd:S000003551
name: YJL014W
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIN2" EXACT []
synonym: "CCT3" EXACT []
synonym: "TCP3" EXACT []

[Term]
id: sgd:S000003552
name: YJL015C
def: "Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex\, overlaps ORF YJL016W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003553
name: YJL016W
def: "Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YJL017W" EXACT []

[Term]
id: sgd:S000003556
name: YJL019W
def: "Nuclear envelope protein; required for SPB insertion\, SPB duplication\, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family \(Sad1-UNC-84 homology\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPS3" EXACT []
synonym: "NEP98" EXACT []
synonym: "YJL018W" EXACT []

[Term]
id: sgd:S000003557
name: YJL020C
def: "Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BBC1" EXACT []
synonym: "MTI1" EXACT []
synonym: "YJL021C" EXACT []

[Term]
id: sgd:S000003559
name: YJL022W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003560
name: YJL023C
def: "Protein required for respiratory growth; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET130" EXACT []

[Term]
id: sgd:S000003561
name: YJL024C
def: "Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APS3" EXACT []
synonym: "YKS7" EXACT []

[Term]
id: sgd:S000003562
name: YJL025W
def: "Component of the core factor \(CF\) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p\, Rrn7p\, and Rrn11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN7" EXACT []

[Term]
id: sgd:S000003563
name: YJL026W
def: "Ribonucleotide-diphosphate reductase \(RNR\)\, small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog\, RNR4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT6" EXACT []
synonym: "RNR2" EXACT []
synonym: "ribonucleotide-diphosphate reductase subunit RNR2" EXACT []

[Term]
id: sgd:S000003564
name: YJL027C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003565
name: YJL028W
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003566
name: YJL029C
def: "Component of the GARP \(Golgi-associated retrograde protein\) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi\, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p\," []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS53" EXACT []

[Term]
id: sgd:S000003567
name: YJL030W
def: "Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAD2" EXACT []
synonym: "spindle checkpoint protein MAD2" EXACT []

[Term]
id: sgd:S000003568
name: YJL031C
def: "Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BET4" EXACT []

[Term]
id: sgd:S000003569
name: YJL032W
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003570
name: YJL033W
def: "DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP4" EXACT []
synonym: "ECM24" EXACT []
synonym: "HCA4" EXACT []
synonym: "RNA-dependent ATPase HCA4" EXACT []

[Term]
id: sgd:S000003571
name: YJL034W
def: "ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIP" EXACT []
synonym: "GRP78" EXACT []
synonym: "Hsp70 family ATPase KAR2" EXACT []
synonym: "KAR2" EXACT []

[Term]
id: sgd:S000003572
name: YJL035C
def: "Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAD2" EXACT []

[Term]
id: sgd:S000003573
name: YJL036W
def: "Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG24" EXACT []
synonym: "CVT13" EXACT []
synonym: "SNX4" EXACT []

[Term]
id: sgd:S000003574
name: YJL037W
def: "Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF\, LOH1/YJL038C\, and the double mutant irc18 loh1 exhibits reduced dityrosine fluorescence relative to the single mutants; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC18" EXACT []
synonym: "OSW6" EXACT []

[Term]
id: sgd:S000003575
name: YJL038C
def: "Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; proposed role in maintenance of genome integrity; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF\, IRC18/YJL037W\, and the double mutant irc18 loh1 exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOH1" EXACT []
synonym: "OSW4" EXACT []

[Term]
id: sgd:S000003576
name: YJL039C
def: "Essential subunit of the inner ring of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport; homologous to human NUP205" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP192" EXACT []

[Term]
id: sgd:S000003577
name: YJL041W
def: "FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex \(NPC\) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p\, Gle2p and two other FG-nucleoporins \(Nup159p and Nup116p\); also found in stable complex with Nic96p and two other FG-nucleoproteins \(Nup49p and Nup57p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NSP1" EXACT []
synonym: "NSP1" EXACT []

[Term]
id: sgd:S000003578
name: YJL042W
def: "Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHP1" EXACT []

[Term]
id: sgd:S000003579
name: YJL043W
def: "Putative protein of unknown function; YJL043W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003580
name: YJL044C
def: "GTPase-activating protein \(GAP\) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP6" EXACT []

[Term]
id: sgd:S000003581
name: YJL045W
def: "Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog\, SDH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDH1b" EXACT []
synonym: "succinate dehydrogenase SDH1b" EXACT []

[Term]
id: sgd:S000003582
name: YJL046W
def: "Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM22" EXACT []
synonym: "LIP3" EXACT []
synonym: "RRG3" EXACT []
synonym: "putative lipoate--protein ligase" EXACT []

[Term]
id: sgd:S000003583
name: YJL047C
def: "Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein\, Rub1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUL8" EXACT []
synonym: "CULC" EXACT []
synonym: "RTT101" EXACT []
synonym: "cullin RTT101" EXACT []

[Term]
id: sgd:S000003584
name: YJL048C
def: "UBX \(ubiquitin regulatory X\) domain-containing protein; interacts with Cdc48p\, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog\, UBX7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUI2" EXACT []
synonym: "UBX6" EXACT []

[Term]
id: sgd:S000003585
name: YJL049W
def: "Putative protein of unknown function; YJL049W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003586
name: YJL050W
def: "ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes\, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain\, with two coiled-coil arms/stalks and a globular fist/KOW domain\, which has RNA binding activity and is required for 5.8S rRNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase MTR4" EXACT []
synonym: "DOB1" EXACT []
synonym: "MTR4" EXACT []

[Term]
id: sgd:S000003587
name: YJL051W
def: "Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p\, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC8" EXACT []

[Term]
id: sgd:S000003588
name: YJL052W
def: "Glyceraldehyde-3-phosphate dehydrogenase \(GAPDH\)\, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1\,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAPDH" EXACT []
synonym: "GLD3" EXACT []
synonym: "TDH1" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1" EXACT []

[Term]
id: sgd:S000003589
name: YJL053W
def: "Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p\, Vps29p\, Vps17p\, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD6" EXACT []
synonym: "PEP8" EXACT []
synonym: "VPS26" EXACT []
synonym: "VPT4" EXACT []
synonym: "retromer subunit PEP8" EXACT []

[Term]
id: sgd:S000003590
name: YJL054W
def: "Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM54" EXACT []

[Term]
id: sgd:S000003591
name: YJL055W
def: "Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA\, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003592
name: YJL056C
def: "Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc\, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZAP1" EXACT []
synonym: "ZRG10" EXACT []

[Term]
id: sgd:S000003593
name: YJL057C
def: "Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IKS1" EXACT []
synonym: "protein kinase IKS1" EXACT []

[Term]
id: sgd:S000003594
name: YJL058C
def: "Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog\, BIT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIT61" EXACT []

[Term]
id: sgd:S000003595
name: YJL059W
def: "Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease \(juvenile onset neuronal ceroid lipofuscinosis\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTN1" EXACT []
synonym: "YHC3" EXACT []

[Term]
id: sgd:S000003596
name: YJL060W
def: "Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA3" EXACT []

[Term]
id: sgd:S000003597
name: YJL061W
def: "Linker nucleoporin component of the nuclear pore complex \(NPC\); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins \(Nsp1p\, Nup159p\, and Nup116p\); relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRB187" EXACT []
synonym: "NUP82" EXACT []
synonym: "linker nucleoporin NUP82" EXACT []

[Term]
id: sgd:S000003598
name: YJL062W
def: "Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol \(GPI\) core structure; mutations affect cell wall integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI7" EXACT []
synonym: "LAS21" EXACT []

[Term]
id: sgd:S000003599
name: YJL063C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRD238" EXACT []
synonym: "MRPL8" EXACT []
synonym: "YmL8" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL8" EXACT []

[Term]
id: sgd:S000003600
name: YJL064W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003601
name: YJL065C
def: "Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p\, Isw2p\, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog\, DPB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DLS1" EXACT []

[Term]
id: sgd:S000003602
name: YJL066C
def: "Mitochondrial intermembrane space protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPM1" EXACT []

[Term]
id: sgd:S000003603
name: YJL067W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003604
name: YJL068C
def: "Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde\, which can be metabolized to S-formylglutathione; similar to human esterase D" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "S-formylglutathione hydrolase" EXACT []
synonym: "SFGH" EXACT []

[Term]
id: sgd:S000003605
name: YJL069C
def: "Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP18" EXACT []

[Term]
id: sgd:S000003606
name: YJL070C
def: "Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog\, YBR284W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "metallo-dependent hydrolase superfamily protein" EXACT []

[Term]
id: sgd:S000003607
name: YJL071W
def: "Acetylglutamate synthase \(glutamate N-acetyltransferase\); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5\,6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG2" EXACT []
synonym: "HRB574" EXACT []
synonym: "acetyl-CoA:L-glutamate N-acetyltransferase" EXACT []

[Term]
id: sgd:S000003608
name: YJL072C
def: "Subunit of the GINS complex \(Sld5p\, Psf1p\, Psf2p\, Psf3p\); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC102" EXACT []
synonym: "PSF2" EXACT []

[Term]
id: sgd:S000003609
name: YJL073W
def: "DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JEM1" EXACT []
synonym: "KAR8" EXACT []

[Term]
id: sgd:S000003610
name: YJL074C
def: "Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required\, with Rec8p\, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMC3" EXACT []
synonym: "cohesin subunit SMC3" EXACT []

[Term]
id: sgd:S000003611
name: YJL075C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APQ13" EXACT []

[Term]
id: sgd:S000003612
name: YJL076W
def: "Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog\, TOF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CFI1" EXACT []
synonym: "ESC5" EXACT []
synonym: "NET1" EXACT []
synonym: "SRM8" EXACT []

[Term]
id: sgd:S000003613
name: YJL077C
def: "Protein with a role in processing of secretory proteins; possible role in vacuolar sorting\, null mutants are hypersensitive to sortin2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICS3" EXACT []

[Term]
id: sgd:S000003614
name: YJL078C
def: "Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily \(cysteine-rich secretory proteins \(CRISP\)\, antigen 5\, and pathogenesis related 1 proteins\); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor\, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRY3" EXACT []

[Term]
id: sgd:S000003615
name: YJL079C
def: "Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily \(cysteine-rich secretory proteins \(CRISP\)\, antigen 5\, and pathogenesis related 1 proteins\); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog\, PRY2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRY1" EXACT []

[Term]
id: sgd:S000003616
name: YJL080C
def: "Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER\, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains\, similar to vertebrate vigilins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCP160" EXACT []

[Term]
id: sgd:S000003617
name: YJL081C
def: "Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACT3" EXACT []
synonym: "ARP4" EXACT []

[Term]
id: sgd:S000003618
name: YJL082W
def: "Protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog\, YKR018C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IML2" EXACT []

[Term]
id: sgd:S000003619
name: YJL083W
def: "EH domain-containing protein; involved in regulating phosphatidylinositol 4\,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog\, IRS4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAX4" EXACT []

[Term]
id: sgd:S000003620
name: YJL084C
def: "Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog\, ALY1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALY2" EXACT []
synonym: "ART3" EXACT []

[Term]
id: sgd:S000003621
name: YJL085W
def: "Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns\[4\,5\]P2-binding protein that localizes to exocytic sites in an actin-independent manner\, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EXO70" EXACT []

[Term]
id: sgd:S000003622
name: YJL086C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003623
name: YJL087C
def: "tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase\, polynucleotide kinase\, and ligase activities; localized at the inner nuclear envelope and partially to polysomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIG1" EXACT []
synonym: "RLG1" EXACT []
synonym: "TRL1" EXACT []
synonym: "tRNA ligase" EXACT []

[Term]
id: sgd:S000003624
name: YJL088W
def: "Ornithine carbamoyltransferase; also known as carbamoylphosphate\:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG3" EXACT []
synonym: "argF" EXACT []
synonym: "ornithine carbamoyltransferase" EXACT []

[Term]
id: sgd:S000003625
name: YJL089W
def: "C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element \(CSRE\) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP4" EXACT []

[Term]
id: sgd:S000003626
name: YJL090C
def: "DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p\, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPB11" EXACT []
synonym: "protein kinase activating protein DPB11" EXACT []

[Term]
id: sgd:S000003627
name: YJL091C
def: "Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol \(GlcN-PI\) forms glucosaminyl\(acyl\)phosphatidylinositol \(GlcN\(acyl\)PI\)\, an intermediate in the biosynthesis of glycosylphosphatidylinositol \(GPI\) anchors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GWT1" EXACT []

[Term]
id: sgd:S000003628
name: YJL092W
def: "DNA helicase and DNA-dependent ATPase; involved in DNA repair and checkpoint recovery\, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; functional homolog of human RTEL1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA helicase SRS2" EXACT []
synonym: "HPR5" EXACT []
synonym: "RADH" EXACT []
synonym: "RADH1" EXACT []
synonym: "SRS2" EXACT []

[Term]
id: sgd:S000003629
name: YJL093C
def: "Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem\, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUK1" EXACT []
synonym: "TOK1" EXACT []
synonym: "YKC1" EXACT []
synonym: "YORK" EXACT []
synonym: "YPK1" EXACT []

[Term]
id: sgd:S000003630
name: YJL094C
def: "Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KHA1" EXACT []

[Term]
id: sgd:S000003631
name: YJL095W
def: "MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein \(MAP\) kinase kinase kinase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCK1" EXACT []
synonym: "LAS3" EXACT []
synonym: "SAP3" EXACT []
synonym: "SLK1" EXACT []
synonym: "SSP31" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase BCK1" EXACT []

[Term]
id: sgd:S000003632
name: YJL096W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL49" EXACT []
synonym: "YmL49" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL49" EXACT []

[Term]
id: sgd:S000003633
name: YJL097W
def: "Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved\, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHS1" EXACT []
synonym: "enoyl-CoA hydratase PHS1" EXACT []

[Term]
id: sgd:S000003634
name: YJL098W
def: "Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p\, Sap155p\, and Sap190p; SAP185 has a paralog\, SAP190\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP185" EXACT []

[Term]
id: sgd:S000003635
name: YJL099W
def: "Member of the ChAPs \(Chs5p-Arf1p-binding proteins\) family; part of the exomer complex that mediates export of specific cargo proteins\, including Chs3p\, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog\, BCH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHS6" EXACT []
synonym: "CSD3" EXACT []

[Term]
id: sgd:S000003636
name: YJL100W
def: "Type II phosphatidylinositol 4-kinase; binds Las17p\, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-phosphatidylinositol 4-kinase LSB6" EXACT []
synonym: "LSB6" EXACT []

[Term]
id: sgd:S000003637
name: YJL101C
def: "Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione \(GSH\) biosynthesis; expression induced by oxidants\, cadmium\, and mercury; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSH1" EXACT []
synonym: "glutamate--cysteine ligase" EXACT []

[Term]
id: sgd:S000003638
name: YJL102W
def: "Mitochondrial elongation factor involved in translational elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEF2" EXACT []

[Term]
id: sgd:S000003639
name: YJL103C
def: "Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism\, based on patterns of expression and sequence analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSM1" EXACT []

[Term]
id: sgd:S000003640
name: YJL104W
def: "Subunit of the import motor \(PAM complex\); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane \(TIM23 complex\); forms a 1\:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIA1" EXACT []
synonym: "PAM16" EXACT []
synonym: "TIM16" EXACT []

[Term]
id: sgd:S000003641
name: YJL105W
def: "Protein of unknown function\, contains a SET domain; SET4 has a paralog\, SET3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SET4" EXACT []

[Term]
id: sgd:S000003642
name: YJL106W
def: "Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability\, activates Ndt80p; IME2 expression is positively regulated by Ime1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IME2" EXACT []
synonym: "SME1" EXACT []
synonym: "protein kinase IME2" EXACT []

[Term]
id: sgd:S000003643
name: YJL107C
def: "Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF\, YJL108C are merged in related fungi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003644
name: YJL108C
def: "Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM10" EXACT []
synonym: "pheromone-regulated protein PRM10" EXACT []

[Term]
id: sgd:S000003645
name: YJL109C
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP10" EXACT []

[Term]
id: sgd:S000003646
name: YJL110C
def: "GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog\, DAL80\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEH1" EXACT []
synonym: "GZF3" EXACT []
synonym: "NIL2" EXACT []

[Term]
id: sgd:S000003647
name: YJL111W
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCT7" EXACT []
synonym: "TCP7" EXACT []

[Term]
id: sgd:S000003648
name: YJL112W
def: "Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog\, CAF4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIS2" EXACT []
synonym: "GAG3" EXACT []
synonym: "MDV1" EXACT []
synonym: "NET2" EXACT []

[Term]
id: sgd:S000003651
name: YJL115W
def: "Nucleosome assembly factor; involved in chromatin assembly and disassembly\, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASF1" EXACT []
synonym: "CIA1" EXACT []
synonym: "nucleosome assembly factor ASF1" EXACT []

[Term]
id: sgd:S000003652
name: YJL116C
def: "Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 \(Atp6p\) and 8 \(Atp8p\) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog\, UTH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCA3" EXACT []
synonym: "SUN family protein NCA3" EXACT []

[Term]
id: sgd:S000003653
name: YJL117W
def: "Endoplasmic reticulum \(ER\) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p\, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO86" EXACT []

[Term]
id: sgd:S000003654
name: YJL118W
def: "Putative protein of unknown function; may interact with ribosomes\, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003655
name: YJL119C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003656
name: YJL120W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003657
name: YJL121C
def: "D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPI1" EXACT []
synonym: "POS18" EXACT []
synonym: "RPE1" EXACT []
synonym: "ribulose-phosphate 3-epimerase RPE1" EXACT []

[Term]
id: sgd:S000003658
name: YJL122W
def: "Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALB1" EXACT []

[Term]
id: sgd:S000003659
name: YJL123C
def: "Protein of unknown function that may interact with ribosomes; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles \(early Golgi\); mtc1 is synthetically lethal with cdc13-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTC1" EXACT []

[Term]
id: sgd:S000003660
name: YJL124C
def: "Lsm \(Like Sm\) protein; forms heteroheptameric complex \(with Lsm2p\, Lsm3p\, Lsm4p\, Lsm5p\, Lsm6p\, and Lsm7p\) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins\, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation\, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM1" EXACT []
synonym: "SPB8" EXACT []

[Term]
id: sgd:S000003661
name: YJL125C
def: "Subunit of tRNA \(1-methyladenosine\) methyltransferase; required\, along with Gcd10p\, for the modification of the adenine at position 58 in tRNAs\, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD14" EXACT []
synonym: "TRM61" EXACT []

[Term]
id: sgd:S000003662
name: YJL126W
def: "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIT2" EXACT []

[Term]
id: sgd:S000003663
name: YJL127C
def: "Putative histone acetylase with a role in transcriptional silencing; sequence-specific activator of histone genes\, binds specifically and cooperatively to pairs of UAS elements in core histone promoters\, functions at or near the TATA box" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRE1" EXACT []
synonym: "SPT10" EXACT []
synonym: "SUD1" EXACT []

[Term]
id: sgd:S000003664
name: YJL128C
def: "MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOG4" EXACT []
synonym: "PBS2" EXACT []
synonym: "SFS4" EXACT []
synonym: "SSK4" EXACT []
synonym: "mitogen-activated protein kinase kinase PBS2" EXACT []

[Term]
id: sgd:S000003665
name: YJL129C
def: "Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p\, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog\, TRK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRK1" EXACT []

[Term]
id: sgd:S000003666
name: YJL130C
def: "Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URA2" EXACT []
synonym: "bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase" EXACT []

[Term]
id: sgd:S000003667
name: YJL131C
def: "Mitochondrial translation initiation factor 3 \(IF3\, mIF3\); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM23" EXACT []

[Term]
id: sgd:S000003668
name: YJL132W
def: "Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003669
name: YJL133W
def: "Iron transporter\, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog\, MRS4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS3" EXACT []

[Term]
id: sgd:S000003670
name: YJL134W
def: "Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate\, regulates ceramide and long-chain base phosphates levels\, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog\, YSR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LBP1" EXACT []
synonym: "LCB3" EXACT []
synonym: "YSR2" EXACT []
synonym: "sphinganine kinase LCB3" EXACT []

[Term]
id: sgd:S000003671
name: YJL135W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003672
name: YJL136C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S21\, no bacterial homolog; RPS21B has a paralog\, RPS21A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS21B" EXACT []
synonym: "S21B" EXACT []
synonym: "S21e" EXACT []
synonym: "S26B" EXACT []
synonym: "YS25" EXACT []
synonym: "ribosomal 40S subunit protein S21B" EXACT []

[Term]
id: sgd:S000003673
name: YJL137C
def: "Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis\, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog\, GLG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLG2" EXACT []
synonym: "glycogenin glucosyltransferase GLG2" EXACT []

[Term]
id: sgd:S000003674
name: YJL138C
def: "Translation initiation factor eIF4A; DEA\(D/H\)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog\, TIF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF2" EXACT []
synonym: "eIF4A" EXACT []
synonym: "translation initiation factor eIF4A" EXACT []

[Term]
id: sgd:S000003675
name: YJL139C
def: "Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog\, KTR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YUR1" EXACT []
synonym: "mannosyltransferase YUR1" EXACT []

[Term]
id: sgd:S000003676
name: YJL140W
def: "RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex\, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B32" EXACT []
synonym: "CTF15" EXACT []
synonym: "DNA-directed RNA polymerase II subunit RPB4" EXACT []
synonym: "RPB4" EXACT []

[Term]
id: sgd:S000003677
name: YJL141C
def: "Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation\, the co-repressor Crf1p to inhibit transcription of ribosomal genes\, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAK1" EXACT []
synonym: "serine/threonine protein kinase YAK1" EXACT []

[Term]
id: sgd:S000003678
name: YJL142C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC9" EXACT []

[Term]
id: sgd:S000003679
name: YJL143W
def: "Essential component of the TIM23 complex; with Tim23p\, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane \(TIM23 complex\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIM17" EXACT []
synonym: "MPI2" EXACT []
synonym: "SMS1" EXACT []
synonym: "TIM17" EXACT []
synonym: "protein transporter TIM17" EXACT []

[Term]
id: sgd:S000003680
name: YJL144W
def: "Cytoplasmic hydrophilin essential in desiccation-rehydration process; expression induced by osmotic stress\, starvation and during stationary phase; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003681
name: YJL145W
def: "Non-classical phosphatidylinositol transfer protein \(PITP\); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum\, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFH5" EXACT []

[Term]
id: sgd:S000003682
name: YJL146W
def: "Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDS2" EXACT []

[Term]
id: sgd:S000003683
name: YJL147C
def: "Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003684
name: YJL148W
def: "RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A34.5" EXACT []
synonym: "CST21" EXACT []
synonym: "DNA-directed RNA polymerase I subunit RPA34" EXACT []
synonym: "RPA34" EXACT []

[Term]
id: sgd:S000003685
name: YJL149W
def: "Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAS1" EXACT []
synonym: "SCF ubiquitin ligase complex subunit DAS1" EXACT []

[Term]
id: sgd:S000003686
name: YJL150W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003687
name: YJL151C
def: "Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNA3" EXACT []

[Term]
id: sgd:S000003688
name: YJL152W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003689
name: YJL153C
def: "Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p\, which bind the UASINO DNA element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APR1" EXACT []
synonym: "INO1" EXACT []
synonym: "inositol-3-phosphate synthase INO1" EXACT []

[Term]
id: sgd:S000003690
name: YJL154C
def: "Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins\, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD9" EXACT []
synonym: "VPS35" EXACT []
synonym: "VPT7" EXACT []

[Term]
id: sgd:S000003691
name: YJL155C
def: "Fructose-2\,6-bisphosphatase\, required for glucose metabolism; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FBP26" EXACT []

[Term]
id: sgd:S000003692
name: YJL156C
def: "Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids\, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAA3" EXACT []
synonym: "SSY5" EXACT []

[Term]
id: sgd:S000003693
name: YJL157C
def: "CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation\, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone\, phosphorylation of Far1p by MAPK Fus3p results in association with\, and inhibition of Cdc28p-Cln\, as well as Msn5p mediated nuclear export of Far1p-Cdc24p\, targeting Cdc24p to polarity sites" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR1" EXACT []
synonym: "cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1" EXACT []

[Term]
id: sgd:S000003694
name: YJL158C
def: "Mannose-containing glycoprotein constituent of the cell wall; member of the PIR \(proteins with internal repeats\) family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW11" EXACT []
synonym: "CCW5" EXACT []
synonym: "CIS3" EXACT []
synonym: "PIR4" EXACT []
synonym: "SCW8" EXACT []

[Term]
id: sgd:S000003695
name: YJL159W
def: "O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1\,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock\, oxidative stress\, and nitrogen limitation; HSP150 has a paralog\, PIR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW7" EXACT []
synonym: "HSP150" EXACT []
synonym: "ORE1" EXACT []
synonym: "PIR2" EXACT []
synonym: "heat shock protein HSP150" EXACT []

[Term]
id: sgd:S000003696
name: YJL160C
def: "Putative protein of unknown function; member of the PIR \(proteins with internal repeats\) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated\, peaking in mitosis; YJL160C has a paralog\, PIR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003697
name: YJL161W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP33" EXACT []

[Term]
id: sgd:S000003698
name: YJL162C
def: "Protein of unknown function; contains a J-domain\, which is a region with homology to the E. coli DnaJ protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JJJ2" EXACT []

[Term]
id: sgd:S000003699
name: YJL163C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003700
name: YJL164C
def: "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p\, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog\, TPK3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKA1" EXACT []
synonym: "SRA3" EXACT []
synonym: "TPK1" EXACT []
synonym: "cAMP-dependent protein kinase catalytic subunit TPK1" EXACT []

[Term]
id: sgd:S000003701
name: YJL165C
def: "Putative protein kinase; overexpression increases sodium and lithium tolerance\, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake\, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog\, KKQ8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL5" EXACT []
synonym: "protein kinase HAL5" EXACT []

[Term]
id: sgd:S000003702
name: YJL166W
def: "Subunit 8 of ubiquinol cytochrome-c reductase \(Complex III\); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COR5" EXACT []
synonym: "QCR8" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 8" EXACT []

[Term]
id: sgd:S000003703
name: YJL167W
def: "Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase" EXACT []
synonym: "BOT3" EXACT []
synonym: "ERG20" EXACT []
synonym: "FDS1" EXACT []
synonym: "FPP1" EXACT []
synonym: "bifunctional (2E" EXACT []

[Term]
id: sgd:S000003704
name: YJL168C
def: "Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 \(H3K36\)\, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain\(CTD\) of Rpo21p; H3K36me3 \(trimethylation\) requires Spt6p\, proline 38 on H3\, CTD of Rpo21p\, Ctk1p\, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EZL1" EXACT []
synonym: "KMT3" EXACT []
synonym: "SET2" EXACT []
synonym: "histone methyltransferase SET2" EXACT []

[Term]
id: sgd:S000003705
name: YJL169W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003706
name: YJL170C
def: "Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASG7" EXACT []

[Term]
id: sgd:S000003707
name: YJL171C
def: "GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1\, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003708
name: YJL172W
def: "Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS1" EXACT []

[Term]
id: sgd:S000003709
name: YJL173C
def: "Subunit of heterotrimeric Replication Protein A \(RPA\); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication\, repair\, recombination; RPA protects against inappropriate telomere recombination\, and upon telomere uncapping\, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p\, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFA3" EXACT []
synonym: "RPA14" EXACT []
synonym: "RPA3" EXACT []

[Term]
id: sgd:S000003710
name: YJL174W
def: "Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects\, aberrant multibudded morphology\, and mating defects" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE9" EXACT []

[Term]
id: sgd:S000003711
name: YJL175W
def: "Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin\, hypersensitivity to 5-fluorouracil\, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003712
name: YJL176C
def: "Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes\, including ADH1\, ADH2\, GAL1\, HO\, INO1 and SUC2; relocates to the cytosol under hypoxic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAF2" EXACT []
synonym: "SWI3" EXACT []
synonym: "TYE2" EXACT []

[Term]
id: sgd:S000003713
name: YJL177W
def: "Ribosomal 60S subunit protein L17B; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog\, RPL17A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L17B" EXACT []
synonym: "L20B" EXACT []
synonym: "L22" EXACT []
synonym: "RPL17B" EXACT []
synonym: "YL17" EXACT []
synonym: "ribosomal 60S subunit protein L17B" EXACT []

[Term]
id: sgd:S000003714
name: YJL178C
def: "Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG27" EXACT []
synonym: "ETF1" EXACT []

[Term]
id: sgd:S000003715
name: YJL179W
def: "Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM6" EXACT []
synonym: "PFD1" EXACT []

[Term]
id: sgd:S000003716
name: YJL180C
def: "Assembly factor for the F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for the assembly of alpha and beta subunits into the F1 sector of the mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP12" EXACT []

[Term]
id: sgd:S000003717
name: YJL181W
def: "Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p\, which binds to the YJL181W promoter region; YJL181W has a paralog\, YJR030C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBH1" EXACT []

[Term]
id: sgd:S000003718
name: YJL182C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003719
name: YJL183W
def: "Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p\, Mnn9p\, Mnn10p\, and Hoc1p\, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNN11" EXACT []

[Term]
id: sgd:S000003720
name: YJL184W
def: "Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p\, Cgi121p\, Pcc1p\, and Bud32p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GON7" EXACT []
synonym: "LDB6" EXACT []
synonym: "PCC2" EXACT []

[Term]
id: sgd:S000003721
name: YJL185C
def: "Pex3p interacting protein\, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated\, peaking in G2 phase; YJL185C is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG36" EXACT []

[Term]
id: sgd:S000003722
name: YJL186W
def: "Alpha-1\,2-mannosyltransferase; responsible for addition of the second alpha-1\,2-linked mannose of the branches on the mannan backbone of oligosaccharides\, localizes to an early Golgi compartment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNN5" EXACT []

[Term]
id: sgd:S000003723
name: YJL187C
def: "Protein kinase that regulates the G2/M transition; regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; phosphorylates conserved tyrosine residue in N-terminus of Hsp90 in cell-cycle associated manner\, thus modulating the ability of Hsp90 to chaperone a selected clientele; homolog of S. pombe Wee1p; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWE1" EXACT []
synonym: "WEE1" EXACT []
synonym: "tyrosine protein kinase SWE1" EXACT []

[Term]
id: sgd:S000003724
name: YJL188C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD19" EXACT []

[Term]
id: sgd:S000003725
name: YJL189W
def: "Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L39" EXACT []
synonym: "L39e" EXACT []
synonym: "L46" EXACT []
synonym: "RPL39" EXACT []
synonym: "RPL46" EXACT []
synonym: "SPB2" EXACT []
synonym: "YL40" EXACT []
synonym: "ribosomal 60S subunit protein L39" EXACT []

[Term]
id: sgd:S000003726
name: YJL190C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog\, RPS22B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS22A" EXACT []
synonym: "RPS24" EXACT []
synonym: "S22A" EXACT []
synonym: "S24A" EXACT []
synonym: "S8" EXACT []
synonym: "YS22" EXACT []
synonym: "ribosomal 40S subunit protein S22A" EXACT []
synonym: "rp50" EXACT []

[Term]
id: sgd:S000003727
name: YJL191W
def: "Protein component of the small \(40S\) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog\, RPS14A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRY2" EXACT []
synonym: "RPS14B" EXACT []
synonym: "S11" EXACT []
synonym: "S14B" EXACT []
synonym: "ribosomal 40S subunit protein S14B" EXACT []
synonym: "rp59B" EXACT []

[Term]
id: sgd:S000003728
name: YJL192C
def: "ER-membrane protein; suppressor of pma1-7\, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOP4" EXACT []

[Term]
id: sgd:S000003729
name: YJL193W
def: "Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003730
name: YJL194W
def: "Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex \(pre-RC\) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase CDC6" EXACT []
synonym: "CDC6" EXACT []

[Term]
id: sgd:S000003731
name: YJL195C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003732
name: YJL196C
def: "Elongase I\, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog\, ELO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELO1" EXACT []
synonym: "fatty acid elongase ELO1" EXACT []

[Term]
id: sgd:S000003733
name: YJL197W
def: "Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP12" EXACT []

[Term]
id: sgd:S000003734
name: YJL198W
def: "Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84\, pho87\, pho89\, pho90\, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog\, PHO87\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO90" EXACT []

[Term]
id: sgd:S000003735
name: YJL199C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MBB1" EXACT []

[Term]
id: sgd:S000003736
name: YJL200C
def: "Putative mitochondrial aconitase isozyme; similarity to Aco1p\, an aconitase required for the TCA cycle; expression induced during growth on glucose\, by amino acid starvation via Gcn4p\, and repressed on ethanol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACO2" EXACT []
synonym: "aconitate hydratase ACO2" EXACT []

[Term]
id: sgd:S000003737
name: YJL201W
def: "Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM25" EXACT []

[Term]
id: sgd:S000003738
name: YJL202C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003739
name: YJL203W
def: "Subunit of the SF3a splicing factor complex; required for spliceosome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP21" EXACT []
synonym: "SPP91" EXACT []

[Term]
id: sgd:S000003740
name: YJL204C
def: "F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCY1" EXACT []

[Term]
id: sgd:S000003741
name: YJL206C
def: "Putative protein of unknown function; similar to transcriptional regulators from the Zn\[2\]-Cys\[6\] binuclear cluster protein family; mRNA is weakly cell cycle regulated\, peaking in S phase; induced rapidly upon MMS treatment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003742
name: YJL205C
def: "Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCE1" EXACT []
synonym: "NCE101" EXACT []
synonym: "YJL205C-A" EXACT []
synonym: "YJL206C-A" EXACT []

[Term]
id: sgd:S000003743
name: YJL207C
def: "AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAA1" EXACT []

[Term]
id: sgd:S000003744
name: YJL208C
def: "Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination\, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND \(programmed nuclear destruction\); encodes ortholog of mammalian endoG" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUC1" EXACT []

[Term]
id: sgd:S000003745
name: YJL209W
def: "Mitochondrial protein\, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP1" EXACT []

[Term]
id: sgd:S000003746
name: YJL210W
def: "RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain\, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT1" EXACT []
synonym: "PAS5" EXACT []
synonym: "PEX2" EXACT []
synonym: "ubiquitin-protein ligase peroxin 2" EXACT []

[Term]
id: sgd:S000003747
name: YJL211C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003748
name: YJL212C
def: "Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSH11" EXACT []
synonym: "HGT1" EXACT []
synonym: "OPT1" EXACT []
synonym: "oligopeptide transporter OPT1" EXACT []

[Term]
id: sgd:S000003749
name: YJL213W
def: "Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network \(MEN\) kinase complex\, Dbf2p/Mob1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003750
name: YJL214W
def: "Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT8" EXACT []
synonym: "hexose transporter HXT8" EXACT []

[Term]
id: sgd:S000003751
name: YJL215C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003752
name: YJL216C
def: "Alpha-glucosidase; specificity for isomaltose\, maltose\, and palatinose\, but not alpha-methylglucoside; most distant member of the IMA isomaltase family\, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization\, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1\,3 linkage of nigerose and turanose and alpha-1\,5 linkage of leucrose and is very sensitive to temperature in vitro" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase IMA5" EXACT []
synonym: "IMA5" EXACT []
synonym: "oligo-1" EXACT []

[Term]
id: sgd:S000003753
name: YJL217W
def: "Cytoplasmic protein involved in the regulation of enolase \(ENO1\); mRNA expression is induced by calcium shortage\, copper deficiency \(via Mac1p\) and the presence of galactose \(via Gal4p\); mRNA expression is also regulated by the cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REE1" EXACT []

[Term]
id: sgd:S000003754
name: YJL218W
def: "Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "acetyltransferase" EXACT []

[Term]
id: sgd:S000003755
name: YJL219W
def: "Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily \(MFS\) transporters\, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT9" EXACT []
synonym: "hexose transporter HXT9" EXACT []

[Term]
id: sgd:S000003756
name: YJL220W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003757
name: YJL221C
def: "Alpha-glucosidase; weak\, but broad substrate specificity for alpha-1\,4- and alpha-1\,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization\, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase IMA4" EXACT []
synonym: "FSP2" EXACT []
synonym: "IMA4" EXACT []
synonym: "oligo-1" EXACT []

[Term]
id: sgd:S000003758
name: YJL222W
def: "Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VTH2" EXACT []

[Term]
id: sgd:S000003759
name: YJL223C
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; active during alcoholic fermentation; regulated by anaerobiosis\, negatively regulated by oxygen; repressed by heme; identical to Pau14p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU1" EXACT []
synonym: "seripauperin PAU1" EXACT []

[Term]
id: sgd:S000003760
name: YJL225C
def: "Putative Y' element ATP-dependent helicase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000003761
name: YJR001W
def: "Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT1" EXACT []

[Term]
id: sgd:S000003762
name: YJR002W
def: "Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing\, interacts with and controls the stability of Imp3p and Imp4p\, essential for viability; similar to human Mpp10p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPP10" EXACT []

[Term]
id: sgd:S000003763
name: YJR003C
def: "Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003764
name: YJR004C
def: "Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination\, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin\, C-terminal half is highly glycosylated and contains GPI anchor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AG(ALPHA)1" EXACT []
synonym: "SAG1" EXACT []

[Term]
id: sgd:S000003765
name: YJR005W
def: "Beta-adaptin; large subunit of the clathrin associated protein complex \(AP-2\); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL1" EXACT []
synonym: "YAP80" EXACT []

[Term]
id: sgd:S000003766
name: YJR006W
def: "Subunit of DNA polymerase delta \(polymerase III\); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p\, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUS2" EXACT []
synonym: "HYS2" EXACT []
synonym: "POL31" EXACT []
synonym: "SDP5" EXACT []

[Term]
id: sgd:S000003767
name: YJR007W
def: "Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUI2" EXACT []
synonym: "translation initiation factor eIF2 subunit alpha" EXACT []

[Term]
id: sgd:S000003768
name: YJR008W
def: "Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C \(PLC1\); expression induced by mild heat-stress on a non-fermentable carbon source\, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo\, the human homolog\, is an ErbB2 interacting protein with an essential function in cell motility" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHO1" EXACT []

[Term]
id: sgd:S000003769
name: YJR009C
def: "Glyceraldehyde-3-phosphate dehydrogenase \(GAPDH\)\, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1\,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog\, TDH3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAPDH" EXACT []
synonym: "GLD2" EXACT []
synonym: "TDH2" EXACT []
synonym: "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2" EXACT []

[Term]
id: sgd:S000003770
name: YJR010C-A
def: "Subunit of the signal peptidase complex \(SPC\); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum \(ER\); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC1" EXACT []

[Term]
id: sgd:S000003771
name: YJR010W
def: "ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation\, essential for assimilatory reduction of sulfate to sulfide\, involved in methionine metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET3" EXACT []
synonym: "sulfate adenylyltransferase" EXACT []

[Term]
id: sgd:S000003772
name: YJR011C
def: "Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003773
name: YJR012C
def: "Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF\, GPI14/YJR013W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003774
name: YJR013W
def: "Glycosylphosphatidylinositol-alpha 1\,4 mannosyltransferase I; involved in GPI anchor biosynthesis\, requires Pbn1p for function; homolog of mammalian PIG-M" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI14" EXACT []
synonym: "PMH1" EXACT []

[Term]
id: sgd:S000003775
name: YJR014W
def: "Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1\, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF22" EXACT []
synonym: "TMA22" EXACT []

[Term]
id: sgd:S000003776
name: YJR015W
def: "Putative protein of unknown function; localizes to endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog\, SNG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003777
name: YJR016C
def: "Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILV3" EXACT []
synonym: "dihydroxy-acid dehydratase ILV3" EXACT []

[Term]
id: sgd:S000003778
name: YJR017C
def: "Peptidylprolyl-cis/trans-isomerase \(PPIase\); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit \(Rpo21p\) C-terminal domain \(CTD\); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESS1" EXACT []
synonym: "PIN1" EXACT []
synonym: "PTF1" EXACT []
synonym: "peptidylprolyl isomerase ESS1" EXACT []

[Term]
id: sgd:S000003779
name: YJR018W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003780
name: YJR019C
def: "Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTE1" EXACT []
synonym: "TES1" EXACT []

[Term]
id: sgd:S000003781
name: YJR020W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003782
name: YJR021C
def: "Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex \(Rec107p-Mei4p-Rec114p\) required for ds break formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MER2" EXACT []
synonym: "REC107" EXACT []

[Term]
id: sgd:S000003783
name: YJR022W
def: "Lsm \(Like Sm\) protein; forms heteroheptameric complex \(with Lsm2p\, Lsm3p\, Lsm4p\, Lsm5p\, Lsm6p\, and Lsm7p\) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA\, pre-snoRNA\, and pre-rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM8" EXACT []

[Term]
id: sgd:S000003784
name: YJR023C
def: "Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003785
name: YJR024C
def: "5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDE1" EXACT []
synonym: "methylthioribulose 1-phosphate dehydratase MDE1" EXACT []

[Term]
id: sgd:S000003786
name: YJR025C
def: "3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-hydroxyanthranilate 3" EXACT []
synonym: "4-dioxygenase" EXACT []
synonym: "BNA1" EXACT []
synonym: "HAD1" EXACT []

[Term]
id: sgd:S000003791
name: YJR030C
def: "Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; YJR030C has a paralog\, YJL181W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBH2" EXACT []

[Term]
id: sgd:S000003792
name: YJR031C
def: "Guanine nucleotide exchange factor for ADP ribosylation factors \(ARFs\); involved in vesicular transport between the Golgi and ER\, Golgi organization\, and actin cytoskeleton organization; GEA1 has a paralog\, GEA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor GEA1" EXACT []
synonym: "GEA1" EXACT []

[Term]
id: sgd:S000003793
name: YJR032W
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR7" EXACT []
synonym: "peptidylprolyl isomerase CPR7" EXACT []

[Term]
id: sgd:S000003794
name: YJR033C
def: "Subunit of RAVE complex \(Rav1p\, Rav2p\, Skp1p\); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAV1" EXACT []
synonym: "SOI3" EXACT []

[Term]
id: sgd:S000003795
name: YJR034W
def: "Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space \(IMS\) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET191" EXACT []

[Term]
id: sgd:S000003796
name: YJR035W
def: "Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-dependent ATPase RAD26" EXACT []
synonym: "RAD26" EXACT []

[Term]
id: sgd:S000003797
name: YJR036C
def: "Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUL4" EXACT []
synonym: "putative E3 ubiquitin-protein ligase HUL4" EXACT []

[Term]
id: sgd:S000003798
name: YJR037W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003799
name: YJR038C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003800
name: YJR039W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003801
name: YJR040W
def: "Voltage-gated chloride channel; localized to the golgi\, the endosomal system\, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model \(+\) RNA virus replication by regulating copper metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLC" EXACT []
synonym: "GEF1" EXACT []

[Term]
id: sgd:S000003802
name: YJR041C
def: "Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPA2" EXACT []
synonym: "URB2" EXACT []

[Term]
id: sgd:S000003803
name: YJR042W
def: "Subunit of the Nup84p subcomplex of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery\, including double-strand break repair\, transcription and chromatin silencing; homologous to human NUP85 aka NUP75" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP85" EXACT []
synonym: "RAT9" EXACT []

[Term]
id: sgd:S000003804
name: YJR043C
def: "Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p\, Rev7p and Pol31p; interacts with Hys2p\, PCNA \(Pol30p\)\, and Pol1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA polymerase delta subunit POL32" EXACT []
synonym: "POL32" EXACT []
synonym: "REV5" EXACT []

[Term]
id: sgd:S000003805
name: YJR044C
def: "Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein \(OB-RGRP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS55" EXACT []

[Term]
id: sgd:S000003806
name: YJR045C
def: "Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane \(TIM23 complex\); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog\, ECM10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENS1" EXACT []
synonym: "Hsp70 family ATPase SSC1" EXACT []
synonym: "SSC1" EXACT []
synonym: "mtHSP70" EXACT []

[Term]
id: sgd:S000003807
name: YJR046W
def: "DNA replication licensing factor; required for pre-replication complex assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDT1" EXACT []
synonym: "SID2" EXACT []
synonym: "TAH11" EXACT []

[Term]
id: sgd:S000003808
name: YJR047C
def: "Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog\, HYP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANB1" EXACT []
synonym: "HYP1" EXACT []
synonym: "TIF51B" EXACT []
synonym: "eIF-5A" EXACT []
synonym: "eIF5A" EXACT []
synonym: "translation elongation factor eIF-5A" EXACT []

[Term]
id: sgd:S000003809
name: YJR048W
def: "Cytochrome c\, isoform 1; also known as iso-1-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; mutations in human homolog cause insulin-responsive hyperglycemia; CYC1 has a paralog\, CYC7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYC1" EXACT []
synonym: "cytochrome c isoform 1" EXACT []

[Term]
id: sgd:S000003810
name: YJR049C
def: "ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase \(Fre1p\); UTR1 has a paralog\, YEF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTR1" EXACT []

[Term]
id: sgd:S000003811
name: YJR050W
def: "Member of the NineTeen Complex \(NTC\); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2\, U5\, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISY1" EXACT []
synonym: "NTC30" EXACT []
synonym: "UTR3" EXACT []

[Term]
id: sgd:S000003812
name: YJR051W
def: "Fumarate reductase\, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites\, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth\, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog\, FRD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRDS2" EXACT []
synonym: "OSM1" EXACT []

[Term]
id: sgd:S000003813
name: YJR052W
def: "Nucleotide excision repair \(NER\) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner \(with Rad16p\) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 \(NEF4\) and the Elongin-Cullin-Socs \(ECS\) ligase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD7" EXACT []
synonym: "UV-damaged DNA-binding protein RAD7" EXACT []

[Term]
id: sgd:S000003814
name: YJR053W
def: "Component of the GTPase-activating Bfa1p-Bub2p complex; involved in multiple cell cycle checkpoint pathways that control exit from mitosis; specifically required when telomeres are damaged\, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BFA1" EXACT []
synonym: "IBD1" EXACT []

[Term]
id: sgd:S000003815
name: YJR054W
def: "Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system \(HACS\) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog\, PRM6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERM6" EXACT []
synonym: "KCH1" EXACT []

[Term]
id: sgd:S000003816
name: YJR055W
def: "Protein involved in C/D snoRNP assembly; regulates abundance of Rsa1p; required for growth at high temperature; similar to human ZNHIT3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIT1" EXACT []

[Term]
id: sgd:S000003817
name: YJR056C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003818
name: YJR057W
def: "Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC8" EXACT []
synonym: "bifunctional thymidylate/uridylate kinase" EXACT []

[Term]
id: sgd:S000003819
name: YJR058C
def: "Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein \(AP-2\) complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APS2" EXACT []
synonym: "YAP17" EXACT []

[Term]
id: sgd:S000003820
name: YJR059W
def: "Putative serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; enhances spermine uptake; PTK2 has a paralog\, PTK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTK2" EXACT []
synonym: "STK2" EXACT []
synonym: "protein kinase PTK2" EXACT []

[Term]
id: sgd:S000003821
name: YJR060W
def: "Basic helix-loop-helix \(bHLH\) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I \(CDEI\); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins\, required for chromosome segregation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF1" EXACT []
synonym: "CEP1" EXACT []
synonym: "CP1" EXACT []
synonym: "CPF1" EXACT []

[Term]
id: sgd:S000003822
name: YJR061W
def: "Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog\, MNN4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003823
name: YJR062C
def: "Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEA1" EXACT []
synonym: "NTA1" EXACT []

[Term]
id: sgd:S000003824
name: YJR063W
def: "RNA polymerase I subunit A12.2; contains two zinc binding domains\, and the N terminal domain is responsible for anchoring to the RNA pol I complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A12.2" EXACT []
synonym: "DNA-directed RNA polymerase I core subunit RPA12" EXACT []
synonym: "RPA12" EXACT []
synonym: "RRN4" EXACT []

[Term]
id: sgd:S000003825
name: YJR064W
def: "Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p\, required for the assembly of actin and tubulins in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCT5" EXACT []
synonym: "TCP5" EXACT []

[Term]
id: sgd:S000003826
name: YJR065C
def: "Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACT4" EXACT []
synonym: "ARP3" EXACT []
synonym: "actin-related protein 3" EXACT []

[Term]
id: sgd:S000003827
name: YJR066W
def: "PIK-related protein kinase and rapamycin target; subunit of TORC1\, a complex that controls growth in response to nutrients by regulating translation\, transcription\, ribosome biogenesis\, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog\, TOR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRR1" EXACT []
synonym: "TOR1" EXACT []
synonym: "phosphatidylinositol kinase-related protein kinase TOR1" EXACT []

[Term]
id: sgd:S000003828
name: YJR067C
def: "Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard \(aerobic\) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAE1" EXACT []

[Term]
id: sgd:S000003829
name: YJR068W
def: "Subunit of heteropentameric Replication factor C \(RF-C\); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen \(PCNA\) processivity factor for DNA polymerases delta and epsilon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFC2" EXACT []
synonym: "replication factor C subunit 2" EXACT []

[Term]
id: sgd:S000003830
name: YJR069C
def: "Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP\, dITP and XTP; mediates exclusion of noncanonical purines and pyrimidines from deoxyribonucleoside triphosphate pools; functions together with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAM1" EXACT []
synonym: "nucleoside triphosphate pyrophosphohydrolase HAM1" EXACT []

[Term]
id: sgd:S000003831
name: YJR070C
def: "Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p \(eIF5A\); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIA1" EXACT []
synonym: "MMD1" EXACT []

[Term]
id: sgd:S000003832
name: YJR071W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003833
name: YJR072C
def: "Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPA1" EXACT []
synonym: "GPN1" EXACT []
synonym: "GTPase NPA3" EXACT []
synonym: "NPA3" EXACT []

[Term]
id: sgd:S000003834
name: YJR073C
def: "Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI3" EXACT []
synonym: "PEM2" EXACT []
synonym: "bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase" EXACT []

[Term]
id: sgd:S000003835
name: YJR074W
def: "Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOG1" EXACT []

[Term]
id: sgd:S000003836
name: YJR075W
def: "Alpha-1\,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p\, Mnn9p\, Mnn11p\, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOC1" EXACT []

[Term]
id: sgd:S000003837
name: YJR076C
def: "Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC11" EXACT []
synonym: "PSL9" EXACT []
synonym: "septin CDC11" EXACT []

[Term]
id: sgd:S000003838
name: YJR077C
def: "Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIR1" EXACT []
synonym: "PTP" EXACT []

[Term]
id: sgd:S000003839
name: YJR078W
def: "Putative tryptophan 2\,3-dioxygenase or indoleamine 2\,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA2" EXACT []
synonym: "dioxygenase BNA2" EXACT []

[Term]
id: sgd:S000003840
name: YJR079W
def: "Putative protein of unknown function; mutation results in impaired mitochondrial respiration" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003841
name: YJR080C
def: "Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM24" EXACT []
synonym: "FMP26" EXACT []

[Term]
id: sgd:S000003842
name: YJR082C
def: "Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF6" EXACT []

[Term]
id: sgd:S000003843
name: YJR083C
def: "Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACF4" EXACT []

[Term]
id: sgd:S000003844
name: YJR084W
def: "Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSN12" EXACT []

[Term]
id: sgd:S000003845
name: YJR085C
def: "Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003846
name: YJR086W
def: "G protein gamma subunit; forms a dimer with Ste4p to activate the mating signaling pathway\, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated\, which are required for normal signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE18" EXACT []

[Term]
id: sgd:S000003847
name: YJR087W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003848
name: YJR088C
def: "Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2\, fly CG17556\, human TTC35" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMC2" EXACT []

[Term]
id: sgd:S000003849
name: YJR089W
def: "Subunit of chromosomal passenger complex \(CPC\); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIR1" EXACT []

[Term]
id: sgd:S000003850
name: YJR090C
def: "F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF \(Cdc53p\, Skp1p and Hrt1p/Rbx1p\) to form the SCF\(Grr1\) complex; SCF\(Grr1\) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as\: Gic2p\, Mks1p\, Mth1p\, Cln1p\, Cln2p and Cln3p; involved in carbon catabolite repression\, glucose-dependent divalent cation transport\, glucose transport\, morphogenesis\, and sulfite detoxification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAT80" EXACT []
synonym: "COT2" EXACT []
synonym: "GRR1" EXACT []
synonym: "SCF ubiquitin ligase complex subunit GRR1" EXACT []
synonym: "SDC1" EXACT []
synonym: "SSU2" EXACT []

[Term]
id: sgd:S000003851
name: YJR091C
def: "Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog\, PUF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JSN1" EXACT []
synonym: "PUF1" EXACT []

[Term]
id: sgd:S000003852
name: YJR092W
def: "Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure\, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD4" EXACT []

[Term]
id: sgd:S000003853
name: YJR093C
def: "Subunit of cleavage polyadenylation factor \(CPF\); interacts directly with poly\(A\) polymerase \(Pap1p\) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIP1" EXACT []

[Term]
id: sgd:S000003854
name: YJR094C
def: "Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IME1" EXACT []
synonym: "transcription factor IME1" EXACT []

[Term]
id: sgd:S000003855
name: YJR094W-A
def: "Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A\, no bacterial homolog; RPL43B has a paralog\, RPL43A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L43B" EXACT []
synonym: "L43e" EXACT []
synonym: "RPL43B" EXACT []
synonym: "ribosomal 60S subunit protein L43B" EXACT []

[Term]
id: sgd:S000003856
name: YJR095W
def: "Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACR1" EXACT []
synonym: "SFC1" EXACT []

[Term]
id: sgd:S000003857
name: YJR096W
def: "Xylose and arabinose reductase; member of the aldo-keto reductase \(AKR\) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "aldo-keto reductase superfamily protein" EXACT []

[Term]
id: sgd:S000003858
name: YJR097W
def: "Protein of unknown function; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH4" EXACT []
synonym: "JJJ3" EXACT []

[Term]
id: sgd:S000003859
name: YJR098C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003860
name: YJR099W
def: "Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YUH1" EXACT []

[Term]
id: sgd:S000003861
name: YJR100C
def: "Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM25" EXACT []

[Term]
id: sgd:S000003862
name: YJR101W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM26" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM26" EXACT []

[Term]
id: sgd:S000003863
name: YJR102C
def: "Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-II subunit protein VPS25" EXACT []
synonym: "VPL12" EXACT []
synonym: "VPS25" EXACT []
synonym: "VPT25" EXACT []

[Term]
id: sgd:S000003864
name: YJR103W
def: "Minor CTP synthase isozyme \(see also URA7\); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP\, forming CTP\, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium\, especially during conditions of glucose depletion; URA8 has a paralog\, URA7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTP synthase URA8" EXACT []
synonym: "URA8" EXACT []

[Term]
id: sgd:S000003865
name: YJR104C
def: "Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p and enters the nucleus under oxidative stress to promote transcription of stress response genes; human ortholog implicated in ALS; abundance increases under DNA replication stress and during exposure to boric acid; localization of a fraction to the mitochondrial intermembrane space is modulated by the MICOS complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRS4" EXACT []
synonym: "SOD1" EXACT []
synonym: "superoxide dismutase SOD1" EXACT []

[Term]
id: sgd:S000003866
name: YJR105W
def: "Adenosine kinase; required for the utilization of S-adenosylmethionine \(AdoMet\); may be involved in recycling adenosine produced through the methyl cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADO1" EXACT []
synonym: "adenosine kinase" EXACT []

[Term]
id: sgd:S000003867
name: YJR106W
def: "Putative protein of unknown function; may play a role in cell wall biosynthesis\, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM27" EXACT []

[Term]
id: sgd:S000003868
name: YJR107W
def: "Putative lipase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative lipase" EXACT []

[Term]
id: sgd:S000003869
name: YJR108W
def: "Protein of unknown function; required for normal microtubule organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABM1" EXACT []

[Term]
id: sgd:S000003870
name: YJR109C
def: "Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline\, an arginine precursor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPA2" EXACT []
synonym: "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2" EXACT []

[Term]
id: sgd:S000003871
name: YJR110W
def: "Phosphatidylinositol 3-phosphate \(PI3P\) phosphatase; involved in various protein sorting pathways\, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMR1" EXACT []
synonym: "phosphatidylinositol-3-phosphatase YMR1" EXACT []

[Term]
id: sgd:S000003872
name: YJR111C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003873
name: YJR112W
def: "Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p \(MIND\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIND complex subunit NNF1" EXACT []
synonym: "NNF1" EXACT []

[Term]
id: sgd:S000003874
name: YJR113C
def: "Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM7" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM7" EXACT []

[Term]
id: sgd:S000003875
name: YJR114W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF2" EXACT []

[Term]
id: sgd:S000003876
name: YJR115W
def: "Putative protein of unknown function; YJR115W has a paralog\, ECM13\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003877
name: YJR116W
def: "Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA4" EXACT []

[Term]
id: sgd:S000003878
name: YJR117W
def: "Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation\, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFC1" EXACT []
synonym: "PIO2" EXACT []
synonym: "STE24" EXACT []

[Term]
id: sgd:S000003879
name: YJR118C
def: "Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILM1" EXACT []

[Term]
id: sgd:S000003880
name: YJR119C
def: "JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; regulates rDNA silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JHD2" EXACT []
synonym: "KDM5" EXACT []

[Term]
id: sgd:S000003881
name: YJR120W
def: "Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2\, impaired respiration\, defective sterol uptake\, and altered levels/localization of ABC transporters Aus1p and Pdr11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003882
name: YJR121W
def: "Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP2" EXACT []
synonym: "F1F0 ATP synthase subunit beta" EXACT []

[Term]
id: sgd:S000003883
name: YJR122W
def: "Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF17" EXACT []
synonym: "IBA57" EXACT []

[Term]
id: sgd:S000003884
name: YJR123W
def: "Protein component of the small \(40S\) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS5" EXACT []
synonym: "S2" EXACT []
synonym: "S5" EXACT []
synonym: "S7" EXACT []
synonym: "YS8" EXACT []
synonym: "ribosomal 40S subunit protein S5" EXACT []
synonym: "rp14" EXACT []

[Term]
id: sgd:S000003885
name: YJR124C
def: "Putative protein of unknown function; expression induced under calcium shortage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003886
name: YJR125C
def: "Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENT3" EXACT []

[Term]
id: sgd:S000003887
name: YJR126C
def: "Protein of unknown function involved in vacuolar protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS70" EXACT []

[Term]
id: sgd:S000003888
name: YJR127C
def: "Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes\, many of which specify products required for glycerol-based growth\, respiration\, and other functions; RSF2 has a paralog\, TDA9\, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSF2" EXACT []
synonym: "ZMS1" EXACT []

[Term]
id: sgd:S000003889
name: YJR128W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003890
name: YJR129C
def: "S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 \(Eft1p and Eft2p\) at lysine 509; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFM3" EXACT []

[Term]
id: sgd:S000003891
name: YJR130C
def: "Cystathionine gamma-synthase\, converts cysteine into cystathionine; STR2 has a paralog\, YML082W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STR2" EXACT []

[Term]
id: sgd:S000003892
name: YJR131W
def: "Alpha-1\,2-mannosidase; involved in ER-associated protein degradation \(ERAD\); catalyzes the removal of one mannose residue from a glycosylated protein\, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-alpha-mannosidase" EXACT []
synonym: "MNS1" EXACT []
synonym: "mannosyl-oligosaccharide 1" EXACT []

[Term]
id: sgd:S000003893
name: YJR132W
def: "Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP119" EXACT []
synonym: "NMD5" EXACT []

[Term]
id: sgd:S000003894
name: YJR133W
def: "Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "XPT1" EXACT []
synonym: "xanthine phosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000003895
name: YJR134C
def: "Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGM1" EXACT []

[Term]
id: sgd:S000003896
name: YJR135C
def: "Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-K and fission yeast sim4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCM22" EXACT []

[Term]
id: sgd:S000003897
name: YJR136C
def: "Subunit of the ASTRA complex\, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TTI2" EXACT []

[Term]
id: sgd:S000003898
name: YJR137C
def: "Sulfite reductase beta subunit; involved in amino acid biosynthesis\, transcription repressed by methionine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM17" EXACT []
synonym: "MET5" EXACT []
synonym: "sulfite reductase (NADPH) subunit beta" EXACT []

[Term]
id: sgd:S000003899
name: YJR138W
def: "GTPase-activating protein \(GAP\)\, subunit of SEA and Iml1p complexes; SEA \(Seh1-associated\) complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex \(Iml1p-Npr2p-Npr3p\) is required for non-nitrogen-starvation \(NNS\)-induced autophagy; localized to either pre-autophagosomal structures \(PAS\) or non-PAS structures during NNS-induced autophagy;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IML1" EXACT []
synonym: "SEA1" EXACT []

[Term]
id: sgd:S000003900
name: YJR139C
def: "Homoserine dehydrogenase \(L-homoserine\:NADP oxidoreductase\); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding\, dimerization and catalytic regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOM6" EXACT []
synonym: "THR6" EXACT []
synonym: "homoserine dehydrogenase" EXACT []

[Term]
id: sgd:S000003901
name: YJR140C
def: "Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIR3" EXACT []
synonym: "HPC1" EXACT []

[Term]
id: sgd:S000003902
name: YJR141W
def: "Essential protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003903
name: YJR142W
def: "8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003904
name: YJR143C
def: "Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT4" EXACT []

[Term]
id: sgd:S000003905
name: YJR144W
def: "Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins\, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid\, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGM101" EXACT []
synonym: "MGM9" EXACT []

[Term]
id: sgd:S000003906
name: YJR145C
def: "Protein component of the small \(40S\) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4\, no bacterial homolog; RPS4A has a paralog\, RPS4B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS4A" EXACT []
synonym: "S4A" EXACT []
synonym: "S4e" EXACT []
synonym: "S7A" EXACT []
synonym: "YS6" EXACT []
synonym: "ribosomal 40S subunit protein S4A" EXACT []
synonym: "rp5" EXACT []

[Term]
id: sgd:S000003907
name: YJR146W
def: "Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003908
name: YJR147W
def: "Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog\, SKN7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMS2" EXACT []

[Term]
id: sgd:S000003909
name: YJR148W
def: "Cytosolic branched-chain amino acid \(BCAA\) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog\, BAT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAT2" EXACT []
synonym: "ECA40" EXACT []
synonym: "TWT2" EXACT []
synonym: "branched-chain-amino-acid transaminase BAT2" EXACT []

[Term]
id: sgd:S000003910
name: YJR149W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003911
name: YJR150C
def: "Cell wall mannoprotein; has similarity to Tir1p\, Tir2p\, Tir3p\, and Tir4p; expressed under anaerobic conditions\, completely repressed during aerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW13" EXACT []
synonym: "DAN1" EXACT []

[Term]
id: sgd:S000003912
name: YJR151C
def: "Cell wall mannoprotein; has similarity to Tir1p\, Tir2p\, Tir3p\, and Tir4p; expressed under anaerobic conditions\, completely repressed during aerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAN4" EXACT []

[Term]
id: sgd:S000003913
name: YJR152W
def: "Allantoate permease; ureidosuccinate permease; also transports dipeptides\, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL5" EXACT []
synonym: "UREP1" EXACT []
synonym: "allantoate permease" EXACT []

[Term]
id: sgd:S000003914
name: YJR153W
def: "Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1\,4-glycosidic bonds in the rhamnogalacturonan chains in pectins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGL1" EXACT []
synonym: "PGU1" EXACT []
synonym: "PSM1" EXACT []

[Term]
id: sgd:S000003915
name: YJR154W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003916
name: YJR155W
def: "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs \(AAD3 + AAD15\, AAD6/AAD16 + AAD4\, AAD10 + AAD14\) whose two genes are more related to one another than to other members of the family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAD10" EXACT []

[Term]
id: sgd:S000003917
name: YJR156C
def: "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5\, THI11\, THI12\, and THI13; hydroxymethylpyrimidine is also known as HMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI11" EXACT []

[Term]
id: sgd:S000003918
name: YJR157W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003919
name: YJR158W
def: "Protein of unknown function with similarity to hexose transporters; expression is repressed by high levels of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT16" EXACT []
synonym: "hexose transporter HXT16" EXACT []

[Term]
id: sgd:S000003920
name: YJR159W
def: "Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L-iditol 2-dehydrogenase SOR1" EXACT []
synonym: "SDH1" EXACT []
synonym: "SOR1" EXACT []

[Term]
id: sgd:S000003921
name: YJR160C
def: "Alpha-glucoside permease; transports maltose\, maltotriose\, alpha-methylglucoside\, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPH3" EXACT []

[Term]
id: sgd:S000003922
name: YJR161C
def: "Protein of unknown function; member the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS5" EXACT []

[Term]
id: sgd:S000003923
name: YJR162C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003924
name: YLL001W
def: "Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNM1" EXACT []
synonym: "dynamin-related GTPase DNM1" EXACT []

[Term]
id: sgd:S000003925
name: YLL002W
def: "Histone acetyltransferase; critical for cell survival in the presence of DNA damage during S phase; prevents hyper-amplification of rDNA; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H3 histone acetyltransferase RTT109" EXACT []
synonym: "KAT11" EXACT []
synonym: "KIM2" EXACT []
synonym: "REM50" EXACT []
synonym: "RTT109" EXACT []

[Term]
id: sgd:S000003926
name: YLL003W
def: "Centrin \(Cdc31p\)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body \(SPB\); required for progression through G\(2\)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFI1" EXACT []

[Term]
id: sgd:S000003927
name: YLL004W
def: "Subunit of the origin recognition complex \(ORC\); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC3" EXACT []
synonym: "origin recognition complex subunit 3" EXACT []

[Term]
id: sgd:S000003928
name: YLL005C
def: "Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO75" EXACT []

[Term]
id: sgd:S000003929
name: YLL006W
def: "ER integral membrane protein\, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERMES complex subunit MMM1" EXACT []
synonym: "MMM1" EXACT []
synonym: "YME6" EXACT []

[Term]
id: sgd:S000003930
name: YLL007C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003931
name: YLL008W
def: "Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DRS1" EXACT []

[Term]
id: sgd:S000003932
name: YLL009C
def: "Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX17" EXACT []
synonym: "copper metallochaperone COX17" EXACT []

[Term]
id: sgd:S000003933
name: YLL010C
def: "Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression\, possibly through dephosphorylation of Msn2p; PSR1 has a paralog\, PSR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSR1" EXACT []

[Term]
id: sgd:S000003934
name: YLL011W
def: "Protein required for biogenesis of 40S \(small\) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOF1" EXACT []

[Term]
id: sgd:S000003935
name: YLL012W
def: "Steryl ester hydrolase; one of three gene products \(Yeh1p\, Yeh2p\, Tgl1p\) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog\, YEH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEH1" EXACT []

[Term]
id: sgd:S000003936
name: YLL013C
def: "Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUF3" EXACT []
synonym: "mRNA-binding protein PUF3" EXACT []

[Term]
id: sgd:S000003937
name: YLL014W
def: "Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6\, fly CG11781\, human TMEM93" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMC6" EXACT []

[Term]
id: sgd:S000003938
name: YLL015W
def: "ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane\, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates\, along with Ycf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette bilirubin transporter BPT1" EXACT []
synonym: "BPT1" EXACT []

[Term]
id: sgd:S000003941
name: YLL018C
def: "Aspartyl-tRNA synthetase\, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA\(Asp\); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity \(HBSL\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AspRS" EXACT []
synonym: "DPS1" EXACT []
synonym: "aspartate--tRNA ligase DPS1" EXACT []

[Term]
id: sgd:S000003942
name: YLL019C
def: "Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases\, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KNS1" EXACT []
synonym: "L124" EXACT []
synonym: "serine/threonine protein kinase KNS1" EXACT []

[Term]
id: sgd:S000003943
name: YLL020C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003944
name: YLL021W
def: "Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog\, SPH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUS6" EXACT []
synonym: "PEA1" EXACT []
synonym: "PPF1" EXACT []
synonym: "SPA2" EXACT []

[Term]
id: sgd:S000003945
name: YLL022C
def: "Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIF1" EXACT []

[Term]
id: sgd:S000003946
name: YLL023C
def: "Transmembrane nucleoporin; involved in nuclear pore complex \(NPC\) distribution\, assembly or stabilization; highly conserved across species\, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POM33" EXACT []
synonym: "nucleoporin POM33" EXACT []

[Term]
id: sgd:S000003947
name: YLL024C
def: "ATP-binding protein; involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 \(HSP70\) family; associated with the chaperonin-containing T-complex; present in the cytoplasm\, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p\, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast \[URE3\] prions and vacuolar-mediated degradations of gluconeogenesis enzymes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family chaperone SSA2" EXACT []
synonym: "SSA2" EXACT []
synonym: "YG102" EXACT []

[Term]
id: sgd:S000003948
name: YLL025W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU17" EXACT []
synonym: "seripauperin PAU17" EXACT []

[Term]
id: sgd:S000003949
name: YLL026W
def: "Disaggregase; heat shock protein that cooperates with Ydj1p \(Hsp40\) and Ssa1p \(Hsp70\) to refold and reactivate previously denatured\, aggregated proteins; responsive to stresses including\: heat\, ethanol\, and sodium arsenite; involved in \[PSI+\] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP104" EXACT []
synonym: "chaperone ATPase HSP104" EXACT []

[Term]
id: sgd:S000003950
name: YLL027W
def: "Protein required for maturation of mitochondrial \[4Fe-4S\] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISA1" EXACT []

[Term]
id: sgd:S000003951
name: YLL028W
def: "Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; recognizes spermine\, putrescine\, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine\, spermidine from the cell\, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPO1" EXACT []

[Term]
id: sgd:S000003952
name: YLL029W
def: "Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p\, Grx3p\, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRA1" EXACT []
synonym: "RUP2" EXACT []

[Term]
id: sgd:S000003953
name: YLL030C
def: "Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT7" EXACT []

[Term]
id: sgd:S000003954
name: YLL031C
def: "ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol \(GPI\) anchor precursor; similar to human PIG-O protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI13" EXACT []
synonym: "MPC1" EXACT []

[Term]
id: sgd:S000003955
name: YLL032C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003956
name: YLL033W
def: "Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GON2" EXACT []
synonym: "IRC19" EXACT []
synonym: "RRG4" EXACT []

[Term]
id: sgd:S000003957
name: YLL034C
def: "Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus\, nucleoplasm\, and nuclear periphery depending on growth conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIX7" EXACT []
synonym: "putative AAA family ATPase RIX7" EXACT []

[Term]
id: sgd:S000003958
name: YLL035W
def: "Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRC3" EXACT []

[Term]
id: sgd:S000003959
name: YLL036C
def: "Splicing factor associated with the spliceosome; contains a U-box\, a motif found in a class of ubiquitin ligases\, and a WD40 domain; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase PRP19" EXACT []
synonym: "PRP19" EXACT []
synonym: "PSO4" EXACT []

[Term]
id: sgd:S000003960
name: YLL037W
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003961
name: YLL038C
def: "Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENT4" EXACT []

[Term]
id: sgd:S000003962
name: YLL039C
def: "Ubiquitin; becomes conjugated to proteins\, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCD2" EXACT []
synonym: "UB14" EXACT []
synonym: "UBI4" EXACT []
synonym: "ubiquitin" EXACT []

[Term]
id: sgd:S000003963
name: YLL040C
def: "Protein involved in prospore membrane morphogenesis; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation\, vacuolar protein sorting\, prospore membrane formation during sporulatoin\, and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome\, respectively" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOI1" EXACT []
synonym: "VPS13" EXACT []
synonym: "VPT2" EXACT []
synonym: "membrane morphogenesis protein VPS13" EXACT []

[Term]
id: sgd:S000003964
name: YLL041C
def: "Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p\, Sdh3p\, and Sdh4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACN17" EXACT []
synonym: "SDH2" EXACT []
synonym: "SDHB" EXACT []
synonym: "succinate dehydrogenase iron-sulfur protein subunit SDH2" EXACT []

[Term]
id: sgd:S000003965
name: YLL042C
def: "Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate\, which is a critical step in autophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG10" EXACT []
synonym: "ATG10" EXACT []

[Term]
id: sgd:S000003966
name: YLL043W
def: "Aquaglyceroporin\, plasma membrane channel; involved in efflux of glycerol and xylitol\, and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; role in mediating passive diffusion of glycerol is key factor in maintenance of redox balance; member of major intrinsic protein \(MIP\) family; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FPS1" EXACT []

[Term]
id: sgd:S000003967
name: YLL044W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003968
name: YLL045C
def: "Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A\, no bacterial homolog; RPL8B has a paralog\, RPL8A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRB1" EXACT []
synonym: "L4B" EXACT []
synonym: "L8B" EXACT []
synonym: "L8e" EXACT []
synonym: "RPL8B" EXACT []
synonym: "SCL41" EXACT []
synonym: "YL5" EXACT []
synonym: "ribosomal 60S subunit protein L8B" EXACT []
synonym: "rp6" EXACT []

[Term]
id: sgd:S000003969
name: YLL046C
def: "Ribonucleoprotein that contains two RNA recognition motifs \(RRM\); RNP1 has a paralog\, SBP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNP1" EXACT []

[Term]
id: sgd:S000003970
name: YLL047W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003971
name: YLL048C
def: "Transporter of the ATP-binding cassette \(ABC\) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog\, VMR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAT1" EXACT []
synonym: "YBT1" EXACT []
synonym: "bile acid-transporting ATPase YBT1" EXACT []

[Term]
id: sgd:S000003972
name: YLL049W
def: "Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB18" EXACT []

[Term]
id: sgd:S000003973
name: YLL050C
def: "Cofilin\, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting\, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COF1" EXACT []
synonym: "cofilin" EXACT []

[Term]
id: sgd:S000003974
name: YLL051C
def: "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE6" EXACT []

[Term]
id: sgd:S000003975
name: YLL052C
def: "Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AQY2" EXACT []

[Term]
id: sgd:S000003976
name: YLL053C
def: "Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003977
name: YLL054C
def: "Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003978
name: YLL055W
def: "High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCT1" EXACT []

[Term]
id: sgd:S000003979
name: YLL056C
def: "Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance \(PDR\); expression is induced in cells treated with the mycotoxin patulin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003980
name: YLL057C
def: "Fe\(II\)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain \(typified by the E. coli DnaJ protein\); induced by sulphur starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JLP1" EXACT []

[Term]
id: sgd:S000003981
name: YLL058W
def: "Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "cystathionine gamma-synthase" EXACT []

[Term]
id: sgd:S000003982
name: YLL059C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003983
name: YLL060C
def: "Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p\, Grx1p\, and Grx2p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTT2" EXACT []
synonym: "glutathione transferase GTT2" EXACT []

[Term]
id: sgd:S000003984
name: YLL061W
def: "High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMP1" EXACT []
synonym: "S-methylmethionine permease MMP1" EXACT []

[Term]
id: sgd:S000003985
name: YLL062C
def: "S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine \(AdoMet\) to methionine to control the methionine/AdoMet ratio" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHT1" EXACT []

[Term]
id: sgd:S000003986
name: YLL063C
def: "Acetyltransferase; catalyzes trichothecene 3-O-acetylation\, suggesting a possible role in trichothecene biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AYT1" EXACT []

[Term]
id: sgd:S000003987
name: YLL064C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU18" EXACT []
synonym: "seripauperin PAU18" EXACT []

[Term]
id: sgd:S000003988
name: YLL065W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIN11" EXACT []

[Term]
id: sgd:S000003989
name: YLL066C
def: "Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000003990
name: YLL067C
def: "Putative Y' element ATP-dependent helicase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000003991
name: YLR001C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000003992
name: YLR002C
def: "Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins\, and is required for pre-RC formation and maintenance during DNA replication licensing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOC3" EXACT []

[Term]
id: sgd:S000003993
name: YLR003C
def: "Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMS1" EXACT []

[Term]
id: sgd:S000003994
name: YLR004C
def: "Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI73" EXACT []

[Term]
id: sgd:S000003995
name: YLR005W
def: "Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSL1" EXACT []
synonym: "TFIIH/NER complex subunit SSL1" EXACT []

[Term]
id: sgd:S000003996
name: YLR006C
def: "Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSK1" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase SSK1" EXACT []

[Term]
id: sgd:S000003997
name: YLR007W
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSE1" EXACT []

[Term]
id: sgd:S000003998
name: YLR008C
def: "Subunit of the import motor \(PAM complex\); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane \(TIM23 complex\); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAM18" EXACT []
synonym: "TIM14" EXACT []

[Term]
id: sgd:S000003999
name: YLR009W
def: "Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p\, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RLP24" EXACT []

[Term]
id: sgd:S000004000
name: YLR010C
def: "Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST \(Cdc13p-Stn1p-Ten1p\) complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TEN1" EXACT []

[Term]
id: sgd:S000004001
name: YLR011W
def: "FMN-dependent NAD\(P\)H\:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOT6" EXACT []

[Term]
id: sgd:S000004002
name: YLR012C
def: "Putative protein of unknown function; YLR012C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004003
name: YLR013W
def: "Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4\, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT3" EXACT []

[Term]
id: sgd:S000004004
name: YLR014C
def: "Zinc finger transcription factor; contains a Zn\(2\)-Cys\(6\) binuclear cluster domain\, positively regulates transcription of URA1\, URA3\, URA4\, and URA10\, which are involved in de novo pyrimidine biosynthesis\, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPR1" EXACT []

[Term]
id: sgd:S000004005
name: YLR015W
def: "Subunit of COMPASS \(Set1C\) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction \(SDI\) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRE2" EXACT []
synonym: "CPS60" EXACT []

[Term]
id: sgd:S000004006
name: YLR016C
def: "Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PML1" EXACT []

[Term]
id: sgd:S000004007
name: YLR017W
def: "Methylthioadenosine phosphorylase \(MTAP\); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase \(Spe1p\) activity; regulates ADH2 gene expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEU1" EXACT []
synonym: "S-methyl-5-thioadenosine phosphorylase" EXACT []

[Term]
id: sgd:S000004008
name: YLR018C
def: "Subunit of the transmembrane ring of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport\, NPC biogenesis and spindle pole body duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POM34" EXACT []

[Term]
id: sgd:S000004009
name: YLR019W
def: "Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression\, possibly through dephosphorylation of Msn2p; PSR2 has a paralog\, PSR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSR2" EXACT []

[Term]
id: sgd:S000004010
name: YLR020C
def: "Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog\, YEH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YEH2" EXACT []

[Term]
id: sgd:S000004011
name: YLR021W
def: "Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DMP2" EXACT []
synonym: "IRC25" EXACT []
synonym: "PBA3" EXACT []
synonym: "POC3" EXACT []

[Term]
id: sgd:S000004012
name: YLR022C
def: "Guanine nucleotide exchange factor \(GEF\) for Ria1p; essential protein involved in ribosome maturation; with Ria1p\, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein \(SBDS\) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDO1" EXACT []
synonym: "guanine nucleotide exchange factor SDO1" EXACT []

[Term]
id: sgd:S000004013
name: YLR023C
def: "Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family\, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase\, overexpression reduces Zap1p activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IZH3" EXACT []

[Term]
id: sgd:S000004014
name: YLR024C
def: "Cytoplasmic ubiquitin-protein ligase \(E3\); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBR2" EXACT []
synonym: "putative ubiquitin-protein ligase UBR2" EXACT []

[Term]
id: sgd:S000004015
name: YLR025W
def: "One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body \(MVB\) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DID1" EXACT []
synonym: "ESCRT-III subunit protein SNF7" EXACT []
synonym: "RNS4" EXACT []
synonym: "SNF7" EXACT []
synonym: "VPL5" EXACT []
synonym: "VPS32" EXACT []

[Term]
id: sgd:S000004016
name: YLR026C
def: "cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SED5" EXACT []

[Term]
id: sgd:S000004017
name: YLR027C
def: "Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAT2" EXACT []
synonym: "ASP5" EXACT []
synonym: "aspartate transaminase AAT2" EXACT []

[Term]
id: sgd:S000004018
name: YLR028C
def: "Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog\, ADE17\, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE16" EXACT []
synonym: "bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16" EXACT []

[Term]
id: sgd:S000004019
name: YLR029C
def: "Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15\, no bacterial homolog; RPL15A has a paralog\, RPL15B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13A" EXACT []
synonym: "L15A" EXACT []
synonym: "L15e" EXACT []
synonym: "RPL10A" EXACT []
synonym: "RPL15A" EXACT []
synonym: "YL10" EXACT []
synonym: "ribosomal 60S subunit protein L15A" EXACT []
synonym: "rp15R" EXACT []

[Term]
id: sgd:S000004020
name: YLR030W
def: "Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004021
name: YLR031W
def: "Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog\, YMR124W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004022
name: YLR032W
def: "DNA helicase/Ubiquitin ligase; involved in error-free branch of DNA damage tolerance \(DDT\) pathway; proposed to promote replication fork regression during postreplication repair by template switching; stimulates synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress; associates with native telomeres\, cooperates with homologous recombination in senescent cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA helicase RAD5" EXACT []
synonym: "RAD5" EXACT []
synonym: "REV2" EXACT []
synonym: "SNM2" EXACT []

[Term]
id: sgd:S000004023
name: YLR033W
def: "Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation\, chromosome stability\, and establishing sister chromatid cohesion; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC58" EXACT []

[Term]
id: sgd:S000004024
name: YLR034C
def: "Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMF3" EXACT []
synonym: "putative divalent metal ion transporter SMF3" EXACT []

[Term]
id: sgd:S000004025
name: YLR035C
def: "Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLH2" EXACT []
synonym: "mismatch repair protein MLH2" EXACT []

[Term]
id: sgd:S000004026
name: YLR036C
def: "Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004027
name: YLR037C
def: "Cell wall mannoprotein; has similarity to Tir1p\, Tir2p\, Tir3p\, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions\, completely repressed during aerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAN2" EXACT []
synonym: "PAU23" EXACT []
synonym: "seripauperin PAU23" EXACT []

[Term]
id: sgd:S000004028
name: YLR038C
def: "Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space\, suggesting a loose association with Complex IV" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX12" EXACT []
synonym: "cytochrome c oxidase subunit VIb" EXACT []

[Term]
id: sgd:S000004029
name: YLR039C
def: "Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIC1" EXACT []

[Term]
id: sgd:S000004030
name: YLR040C
def: "MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFB1" EXACT []

[Term]
id: sgd:S000004031
name: YLR041W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004032
name: YLR042C
def: "Cell wall protein of unknown function; localizes to the cytoplasm; deletion improves xylose fermentation in industrially engineered strains; YLL042C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004033
name: YLR043C
def: "Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p\, facilitates mitochondrial import of small Tims Tim9p\, Tim10p\, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog\, TRX2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LMA1" EXACT []
synonym: "TRX1" EXACT []
synonym: "thioredoxin TRX1" EXACT []

[Term]
id: sgd:S000004034
name: YLR044C
def: "Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-\, ethanol-\, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDC1" EXACT []
synonym: "indolepyruvate decarboxylase 1" EXACT []

[Term]
id: sgd:S000004035
name: YLR045C
def: "Microtubule-associated protein \(MAP\) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STU2" EXACT []

[Term]
id: sgd:S000004036
name: YLR046C
def: "Putative membrane protein; member of the fungal lipid-translocating exporter \(LTE\) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog\, RTA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RLA1" EXACT []

[Term]
id: sgd:S000004037
name: YLR047C
def: "Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE8" EXACT []

[Term]
id: sgd:S000004038
name: YLR048W
def: "Protein component of the small \(40S\) ribosomal subunit; RPS0B has a paralog\, RPS0A\, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate\, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAB1B" EXACT []
synonym: "RPS0B" EXACT []
synonym: "S0B" EXACT []
synonym: "S2" EXACT []
synonym: "YST2" EXACT []
synonym: "ribosomal 40S subunit protein S0B" EXACT []

[Term]
id: sgd:S000004039
name: YLR049C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004040
name: YLR050C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004041
name: YLR051C
def: "Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCF2" EXACT []

[Term]
id: sgd:S000004042
name: YLR052W
def: "Subunit of the INO80 chromatin remodeling complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES3" EXACT []

[Term]
id: sgd:S000004043
name: YLR053C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004044
name: YLR054C
def: "Protein of unknown function reputedly involved in spore wall assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSW2" EXACT []

[Term]
id: sgd:S000004045
name: YLR055C
def: "Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAGA complex subunit SPT8" EXACT []
synonym: "SPT8" EXACT []

[Term]
id: sgd:S000004046
name: YLR056W
def: "C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5\(6\) double bond into episterol\, a precursor in ergosterol biosynthesis; mutants are viable\, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C-5 sterol desaturase" EXACT []
synonym: "ERG3" EXACT []
synonym: "PSO6" EXACT []
synonym: "SYR1" EXACT []

[Term]
id: sgd:S000004047
name: YLR057W
def: "Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase \(GH47\) family members\, such as Mns1p and Mnl1p\, that hydrolyze 1\,2-linked alpha-D-mannose residues; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNL2" EXACT []
synonym: "putative mannosidase MNL2" EXACT []

[Term]
id: sgd:S000004048
name: YLR058C
def: "Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5\,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine\, pyrimidine\, amino acid\, and lipid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHM2" EXACT []
synonym: "SHMT2" EXACT []
synonym: "glycine hydroxymethyltransferase SHM2" EXACT []

[Term]
id: sgd:S000004049
name: YLR059C
def: "3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs\, 5S and 5.8S rRNAs\, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REX2" EXACT []
synonym: "YNT20" EXACT []

[Term]
id: sgd:S000004050
name: YLR060W
def: "Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe\, which could contribute to translational quality control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRS1" EXACT []
synonym: "phenylalanine--tRNA ligase subunit beta" EXACT []

[Term]
id: sgd:S000004051
name: YLR061W
def: "Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22\, no bacterial homolog; RPL22A has a paralog\, RPL22B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L22A" EXACT []
synonym: "L22e" EXACT []
synonym: "RPL22A" EXACT []
synonym: "YL31" EXACT []
synonym: "l1c" EXACT []
synonym: "ribosomal 60S subunit protein L22A" EXACT []
synonym: "rp4" EXACT []

[Term]
id: sgd:S000004052
name: YLR062C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD28" EXACT []

[Term]
id: sgd:S000004053
name: YLR063W
def: "Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BMT6" EXACT []

[Term]
id: sgd:S000004054
name: YLR064W
def: "Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species\, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PER33" EXACT []

[Term]
id: sgd:S000004055
name: YLR065C
def: "Protein proposed to be involved in vacuolar functions; putative role in secretory protein quality control; mutant shows defect in CPY processing; YLR065C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV10" EXACT []

[Term]
id: sgd:S000004056
name: YLR066W
def: "Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p\, Spc2p\, and Sec11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC3" EXACT []

[Term]
id: sgd:S000004057
name: YLR067C
def: "Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats \(PPRs\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET309" EXACT []

[Term]
id: sgd:S000004058
name: YLR068W
def: "Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV7" EXACT []

[Term]
id: sgd:S000004059
name: YLR069C
def: "Mitochondrial elongation factor involved in translational elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEF1" EXACT []

[Term]
id: sgd:S000004060
name: YLR070C
def: "Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose\, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "D-xylulose reductase XYL2" EXACT []
synonym: "XYL2" EXACT []

[Term]
id: sgd:S000004061
name: YLR071C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression\, HO repression\, RME1 repression and sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED14" EXACT []
synonym: "RGR1" EXACT []

[Term]
id: sgd:S000004062
name: YLR072W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; not an esssential gene; YLR072W has a paralog\, YFL042C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004063
name: YLR073C
def: "Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFU1" EXACT []

[Term]
id: sgd:S000004064
name: YLR074C
def: "C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus\, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal \(NLS\) and a nuclear export signal \(NES\); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD20" EXACT []

[Term]
id: sgd:S000004065
name: YLR075W
def: "Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRC5" EXACT []
synonym: "L10" EXACT []
synonym: "L16" EXACT []
synonym: "QSR1" EXACT []
synonym: "RPL10" EXACT []
synonym: "ribosomal 60S subunit protein L10" EXACT []

[Term]
id: sgd:S000004066
name: YLR076C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004067
name: YLR077W
def: "Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III \(cytochrome bc1 complex\); mRNA is targeted to mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCA1" EXACT []
synonym: "FMP25" EXACT []

[Term]
id: sgd:S000004068
name: YLR078C
def: "v-SNARE \(vesicle specific SNAP receptor\); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOS1" EXACT []
synonym: "SEC32" EXACT []

[Term]
id: sgd:S000004069
name: YLR079W
def: "Cyclin-dependent kinase inhibitor \(CKI\); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition\, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF\(CDC4\)-dependent turnover; functional homolog of mammalian Kip1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDB25" EXACT []
synonym: "SIC1" EXACT []
synonym: "cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1" EXACT []

[Term]
id: sgd:S000004070
name: YLR080W
def: "Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog\, EMP47\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMP46" EXACT []

[Term]
id: sgd:S000004071
name: YLR081W
def: "Galactose permease; required for utilization of galactose; also able to transport glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL2" EXACT []
synonym: "galactose permease GAL2" EXACT []

[Term]
id: sgd:S000004072
name: YLR082C
def: "Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRL2" EXACT []

[Term]
id: sgd:S000004073
name: YLR083C
def: "Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog\, TMN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMP70" EXACT []
synonym: "TMN1" EXACT []
synonym: "p24a" EXACT []

[Term]
id: sgd:S000004074
name: YLR084C
def: "N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAX2" EXACT []

[Term]
id: sgd:S000004075
name: YLR085C
def: "Actin-related protein that binds nucleosomes; a component of the SWR1 complex\, which exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP6" EXACT []

[Term]
id: sgd:S000004076
name: YLR086W
def: "Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity\, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMC4" EXACT []
synonym: "condensin subunit SMC4" EXACT []

[Term]
id: sgd:S000004077
name: YLR087C
def: "Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSF1" EXACT []

[Term]
id: sgd:S000004078
name: YLR088W
def: "Subunit of the GPI\:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI \(glycosylphosphatidylinositol\) to proteins in the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END2" EXACT []
synonym: "GAA1" EXACT []

[Term]
id: sgd:S000004079
name: YLR089C
def: "Alanine transaminase \(glutamic pyruvic transaminase\); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog\, ALT2\, that arose from the whole genome duplication; Alt2p is catalytically inactive" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALT1" EXACT []
synonym: "alanine transaminase ALT1" EXACT []

[Term]
id: sgd:S000004080
name: YLR090W
def: "Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family\, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "XDJ1" EXACT []

[Term]
id: sgd:S000004081
name: YLR091W
def: "Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEP5" EXACT []
synonym: "RRG5" EXACT []

[Term]
id: sgd:S000004082
name: YLR092W
def: "High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p\, which control the concentration of endogenous activated sulfate intermediates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUL2" EXACT []

[Term]
id: sgd:S000004083
name: YLR093C
def: "v-SNARE component of the vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca\(2+\) transport activity of Pmc1p in the vacuolar membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAM2" EXACT []
synonym: "NYV1" EXACT []

[Term]
id: sgd:S000004084
name: YLR094C
def: "Protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIS3" EXACT []

[Term]
id: sgd:S000004085
name: YLR095C
def: "Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IOC2" EXACT []

[Term]
id: sgd:S000004086
name: YLR096W
def: "Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog\, KIN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIN2" EXACT []
synonym: "serine/threonine protein kinase KIN2" EXACT []

[Term]
id: sgd:S000004087
name: YLR097C
def: "Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p\, Skp1p and Ubi4 in large and small-scale studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRT3" EXACT []
synonym: "SCF ubiquitin ligase complex subunit HRT3" EXACT []

[Term]
id: sgd:S000004088
name: YLR098C
def: "DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine \(L-threonine\) deaminase \(CHA1\); Zinc-finger protein with Zn\[2\]-Cys\[6\] fungal-type binuclear cluster domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHA4" EXACT []
synonym: "SIL2" EXACT []
synonym: "SIL3" EXACT []

[Term]
id: sgd:S000004089
name: YLR099C
def: "Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog\, ECM18\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICT1" EXACT []
synonym: "lysophosphatidic acid acyltransferase ICT1" EXACT []

[Term]
id: sgd:S000004090
name: YLR100W
def: "3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-keto-steroid reductase" EXACT []
synonym: "ERG27" EXACT []

[Term]
id: sgd:S000004091
name: YLR101C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified\, essential ORF ERG27/YLR100W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004092
name: YLR102C
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC9" EXACT []
synonym: "anaphase promoting complex subunit 9" EXACT []

[Term]
id: sgd:S000004093
name: YLR103C
def: "DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p\, recruits elongation machinery; binds tightly to ssDNA\, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC45" EXACT []
synonym: "SLD4" EXACT []

[Term]
id: sgd:S000004094
name: YLR104W
def: "Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation \(ERAD\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCL2" EXACT []

[Term]
id: sgd:S000004095
name: YLR105C
def: "Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p\, Sen15p\, Sen34p\, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEN2" EXACT []

[Term]
id: sgd:S000004096
name: YLR106C
def: "Huge dynein-related AAA-type ATPase \(midasin\); forms extended pre-60S particle with the Rix1 complex \(Rix1p-Ipi1p-Ipi3p\); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase midasin" EXACT []
synonym: "MDN1" EXACT []
synonym: "REA1" EXACT []

[Term]
id: sgd:S000004097
name: YLR107W
def: "RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REX3" EXACT []

[Term]
id: sgd:S000004098
name: YLR108C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog\, YDR132C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004099
name: YLR109W
def: "Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AHP1" EXACT []
synonym: "cTPxIII" EXACT []

[Term]
id: sgd:S000004100
name: YLR110C
def: "Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds\, septum region of larger buds\, and shmoo tip; CCW12 has a paralog\, YDR134C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW12" EXACT []

[Term]
id: sgd:S000004101
name: YLR111W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004102
name: YLR112W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004103
name: YLR113W
def: "Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII in osmotic shock; activates CDC28 by stimulating antisense RNA transcription; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; with Mrc1p defines novel S-phase checkpoint that prevent conflicts between DNA replication and transcription; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOG1" EXACT []
synonym: "SSK3" EXACT []
synonym: "mitogen-activated protein kinase HOG1" EXACT []

[Term]
id: sgd:S000004104
name: YLR114C
def: "Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVL9" EXACT []

[Term]
id: sgd:S000004105
name: YLR115W
def: "Subunit of the mRNA cleavage and polyadenlylation factor \(CPF\); required for pre-mRNA cleavage\, polyadenylation and poly\(A\) site recognition\, 43% similarity with the mammalian CPSF-100 protein." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CFT2" EXACT []
synonym: "YDH1" EXACT []

[Term]
id: sgd:S000004106
name: YLR116W
def: "Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p\, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BBP" EXACT []
synonym: "MSL5" EXACT []

[Term]
id: sgd:S000004107
name: YLR117C
def: "Member of the NineTeen Complex \(NTC\); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLF1" EXACT []
synonym: "NTC77" EXACT []
synonym: "SYF3" EXACT []

[Term]
id: sgd:S000004108
name: YLR118C
def: "Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APT1" EXACT []
synonym: "palmitoyl-(protein) hydrolase" EXACT []

[Term]
id: sgd:S000004109
name: YLR119W
def: "Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-I subunit protein SRN2" EXACT []
synonym: "SRN10" EXACT []
synonym: "SRN2" EXACT []
synonym: "VPL16" EXACT []
synonym: "VPS37" EXACT []

[Term]
id: sgd:S000004110
name: YLR120C
def: "Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol \(GPI\) anchor; YPS1 has a paralog\, MKC7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP3" EXACT []
synonym: "YPS1" EXACT []

[Term]
id: sgd:S000004111
name: YLR121C
def: "Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol \(GPI\) anchor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPS3" EXACT []
synonym: "YPS4" EXACT []

[Term]
id: sgd:S000004112
name: YLR122C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004113
name: YLR123C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004114
name: YLR124W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004115
name: YLR125W
def: "Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004116
name: YLR126C
def: "Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative amidotransferase" EXACT []

[Term]
id: sgd:S000004117
name: YLR127C
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC2" EXACT []
synonym: "RSI1" EXACT []
synonym: "TID2" EXACT []
synonym: "anaphase promoting complex subunit 2" EXACT []

[Term]
id: sgd:S000004118
name: YLR128W
def: "Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain \(UBA\) for ubiquitin and Nedd8 \(Rub1p\) interaction and a PONY domain involved in cullin binding and neddylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCN1" EXACT []
synonym: "NEDD8 ligase DCN1" EXACT []

[Term]
id: sgd:S000004119
name: YLR129W
def: "Nucleolar protein; specifically associated with the U3 snoRNA\, part of the large ribonucleoprotein complex known as the small subunit \(SSU\) processome\, required for 18S rRNA biogenesis\, part of the active pre-rRNA processing complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIP2" EXACT []
synonym: "UTP12" EXACT []

[Term]
id: sgd:S000004120
name: YLR130C
def: "Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZRT2" EXACT []
synonym: "low-affinity Zn(2+) transporter ZRT2" EXACT []

[Term]
id: sgd:S000004121
name: YLR131C
def: "Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition\, causing localization to daughter cell nuclei\, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog\, SWI5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACE2" EXACT []
synonym: "DNA-binding transcription factor ACE2" EXACT []

[Term]
id: sgd:S000004122
name: YLR132C
def: "Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly\(u\) tract to leave a terminal 3' phosphate; human homolog\, hUSB1 \(aka C16orf57\) produces a 2'\,3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition \(OMIM 604173\); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "USB1" EXACT []

[Term]
id: sgd:S000004123
name: YLR133W
def: "Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline \(Kennedy pathway\); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog\, EKI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKI1" EXACT []
synonym: "bifunctional choline kinase/ethanolamine kinase CKI1" EXACT []

[Term]
id: sgd:S000004124
name: YLR134W
def: "Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation\, decarboxylates pyruvate to acetaldehyde\, regulation is glucose- and ethanol-dependent\, repressed by thiamine\, involved in amino acid catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDC5" EXACT []
synonym: "indolepyruvate decarboxylase 5" EXACT []

[Term]
id: sgd:S000004125
name: YLR135W
def: "Endonuclease involved in processing DNA; acts during recombination and repair; promotes template switching during break-induced replication \(BIR\)\, causing non-reciprocal translocations \(NRTs\); cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLX4" EXACT []

[Term]
id: sgd:S000004126
name: YLR136C
def: "mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog\, CTH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTH2" EXACT []
synonym: "TIS11" EXACT []

[Term]
id: sgd:S000004127
name: YLR137W
def: "Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKM5" EXACT []

[Term]
id: sgd:S000004128
name: YLR138W
def: "Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NHA1" EXACT []

[Term]
id: sgd:S000004129
name: YLR139C
def: "Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLS1" EXACT []

[Term]
id: sgd:S000004130
name: YLR140W
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004131
name: YLR141W
def: "Protein involved in transcription of rDNA by RNA polymerase I; transcription factor\, member of UAF \(upstream activation factor\) family along with Rrn9p and Rrn10p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN5" EXACT []

[Term]
id: sgd:S000004132
name: YLR142W
def: "Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUT1" EXACT []
synonym: "proline dehydrogenase" EXACT []

[Term]
id: sgd:S000004133
name: YLR143W
def: "Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin\, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein \(GFP\)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH6" EXACT []

[Term]
id: sgd:S000004134
name: YLR144C
def: "Intracellular beta-1\,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACF2" EXACT []
synonym: "ENG2" EXACT []
synonym: "PCA1" EXACT []

[Term]
id: sgd:S000004135
name: YLR145W
def: "Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits\, not shared between RNase MRP and nuclear RNase P" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RMP1" EXACT []

[Term]
id: sgd:S000004136
name: YLR146C
def: "Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPE4" EXACT []
synonym: "spermine synthase" EXACT []

[Term]
id: sgd:S000004137
name: YLR147C
def: "Core Sm protein Sm D3; part of heteroheptameric complex \(with Smb1p\, Smd1p\, Smd2p\, Sme1p\, Smx3p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm D3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLT16" EXACT []
synonym: "SMD3" EXACT []
synonym: "Sm D3" EXACT []

[Term]
id: sgd:S000004138
name: YLR148W
def: "Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins\, required for vacuolar biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP3" EXACT []
synonym: "VAM8" EXACT []
synonym: "VPS18" EXACT []
synonym: "VPT18" EXACT []
synonym: "tethering complex subunit PEP3" EXACT []

[Term]
id: sgd:S000004139
name: YLR149C
def: "Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004140
name: YLR150W
def: "Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPT4" EXACT []
synonym: "STM1" EXACT []

[Term]
id: sgd:S000004141
name: YLR151C
def: "8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives\, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human\, rat and mouse MTH1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCD1" EXACT []

[Term]
id: sgd:S000004142
name: YLR152C
def: "Putative protein of unknown function; YLR152C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004143
name: YLR153C
def: "Acetyl-coA synthetase isoform; along with Acs1p\, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACS2" EXACT []
synonym: "acetate--CoA ligase ACS2" EXACT []

[Term]
id: sgd:S000004144
name: YLR154C
def: "Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNH203" EXACT []
synonym: "Rnh2C" EXACT []

[Term]
id: sgd:S000004145
name: YLR155C
def: "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-1 has a paralog\, ASP3-3\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASP3" EXACT []
synonym: "ASP3-1" EXACT []
synonym: "asparaginase ASP3-1" EXACT []

[Term]
id: sgd:S000004146
name: YLR156W
def: "Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog\, YLR159W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004147
name: YLR157C
def: "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog\, ASP3-4\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASP3" EXACT []
synonym: "ASP3-2" EXACT []
synonym: "asparaginase ASP3-2" EXACT []

[Term]
id: sgd:S000004148
name: YLR158C
def: "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog\, ASP3-1\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASP3" EXACT []
synonym: "ASP3-3" EXACT []
synonym: "asparaginase ASP3-3" EXACT []

[Term]
id: sgd:S000004149
name: YLR159W
def: "Putative protein of unknown function; YLR156W\, YLR159W\, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog\, YLR156W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004150
name: YLR160C
def: "Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog\, ASP3-2\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASP3" EXACT []
synonym: "ASP3-4" EXACT []
synonym: "asparaginase ASP3-4" EXACT []

[Term]
id: sgd:S000004151
name: YLR161W
def: "Putative protein of unknown function; YLR156W\, YLR159W\, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog\, YLR157W-D\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004152
name: YLR162W
def: "Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest\, apoptosis\, and increased sensitivity to cobalt chloride" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004153
name: YLR163C
def: "Beta subunit of the mitochondrial processing protease \(MPP\); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS1" EXACT []
synonym: "MIF1" EXACT []

[Term]
id: sgd:S000004154
name: YLR164W
def: "Putative alternate subunit of succinate dehydrogenase \(SDH\); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3\, GAT1-dependent manner; Shh4p has greater similarity to human SDHD \(subunit D of SDH\, implicated in paraganglioma\) than does its paralog Sdh4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHH4" EXACT []
synonym: "protein SHH4" EXACT []

[Term]
id: sgd:S000004155
name: YLR165C
def: "Pseudouridine synthase; catalyzes only the formation of pseudouridine \(Psi\)-2819 in mitochondrial 21S rRNA; not essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS5" EXACT []
synonym: "pseudouridine synthase PUS5" EXACT []

[Term]
id: sgd:S000004156
name: YLR166C
def: "Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC10" EXACT []

[Term]
id: sgd:S000004157
name: YLR167W
def: "Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS31" EXACT []
synonym: "RPS37" EXACT []
synonym: "S31" EXACT []
synonym: "S31e" EXACT []
synonym: "S37" EXACT []
synonym: "UB13" EXACT []
synonym: "UBI3" EXACT []
synonym: "YS24" EXACT []
synonym: "ubiquitin-ribosomal 40S subunit protein S31 fusion protein" EXACT []

[Term]
id: sgd:S000004158
name: YLR168C
def: "Mitochondrial intermembrane space protein; involved in phospholipid metabolism; has role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p\, Ups3p and to human PRELI; UPS2 has a paralog\, UPS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM30" EXACT []
synonym: "GEP1" EXACT []
synonym: "MSF1" EXACT []
synonym: "MSF1'" EXACT []
synonym: "UPS2" EXACT []

[Term]
id: sgd:S000004159
name: YLR169W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004160
name: YLR170C
def: "Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APS1" EXACT []
synonym: "YAP19" EXACT []

[Term]
id: sgd:S000004161
name: YLR171W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004162
name: YLR172C
def: "Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 \(Eft1p or Eft2p\); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH5" EXACT []
synonym: "diphthine synthase" EXACT []

[Term]
id: sgd:S000004163
name: YLR173W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004164
name: YLR174W
def: "Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog\, IDP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDP2" EXACT []
synonym: "isocitrate dehydrogenase (NADP(+)) IDP2" EXACT []

[Term]
id: sgd:S000004165
name: YLR175W
def: "Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs\, on snRNA U2\, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF5" EXACT []
synonym: "pseudouridine synthase CBF5" EXACT []

[Term]
id: sgd:S000004166
name: YLR176C
def: "Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT1" EXACT []
synonym: "RFX1" EXACT []

[Term]
id: sgd:S000004167
name: YLR177W
def: "Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog\, PSP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004168
name: YLR178C
def: "Inhibitor of carboxypeptidase Y \(Prc1p\)\, and Ras GAP \(Ira2p\); phosphatidylethanolamine-binding protein \(PEBP\) family member and ortholog of hPEBP1/RKIP\, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DKA1" EXACT []
synonym: "TFS1" EXACT []

[Term]
id: sgd:S000004169
name: YLR179C
def: "Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004170
name: YLR180W
def: "S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog\, SAM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ETH10" EXACT []
synonym: "SAM1" EXACT []
synonym: "methionine adenosyltransferase SAM1" EXACT []

[Term]
id: sgd:S000004171
name: YLR181C
def: "Multivesicular body \(MVB\) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain\, a linker region\, and a C-terminal Vps4p binding domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VTA1" EXACT []

[Term]
id: sgd:S000004172
name: YLR182W
def: "Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p\, which regulates Swi6p localization; required for the unfolded protein response\, independently of its known transcriptional coactivators" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSL8" EXACT []
synonym: "SDS11" EXACT []
synonym: "SWI6" EXACT []
synonym: "transcriptional regulator SWI6" EXACT []

[Term]
id: sgd:S000004173
name: YLR183C
def: "Putative transcription factor\, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase \(HDAC\) complexes; APCC\(Cdh1\) substrate; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog\, PLM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS4" EXACT []

[Term]
id: sgd:S000004174
name: YLR184W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004175
name: YLR185W
def: "Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37\, no bacterial homolog; RPL37A has a paralog\, RPL37B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L37A" EXACT []
synonym: "L37e" EXACT []
synonym: "L43" EXACT []
synonym: "RPL37A" EXACT []
synonym: "YL35" EXACT []
synonym: "ribosomal 60S subunit protein L37A" EXACT []

[Term]
id: sgd:S000004176
name: YLR186W
def: "Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome\, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMG1" EXACT []
synonym: "NEP1" EXACT []

[Term]
id: sgd:S000004177
name: YLR187W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery\, cytoplasm\, bud\, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog\, CAF120\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKG3" EXACT []

[Term]
id: sgd:S000004178
name: YLR188W
def: "Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette permease MDL1" EXACT []
synonym: "MDL1" EXACT []

[Term]
id: sgd:S000004179
name: YLR189C
def: "UDP-glucose\:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris\, S. cerevisiae ATG26 is not involved in autophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG26" EXACT []
synonym: "UGT51" EXACT []

[Term]
id: sgd:S000004180
name: YLR190W
def: "Phosphorylated protein of the mitochondrial outer membrane; localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMR1" EXACT []

[Term]
id: sgd:S000004181
name: YLR191W
def: "Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS20" EXACT []
synonym: "PEX13" EXACT []

[Term]
id: sgd:S000004182
name: YLR192C
def: "eIF3j component of translation initiation factor 3 \(eIF3\); dual function protein involved in translation initiation as a substoichiometric component \(eIF3j\) of eIF3; required for processing of 20S pre-rRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag\:GFP protein levels; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCR1" EXACT []

[Term]
id: sgd:S000004183
name: YLR193C
def: "Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UPS1" EXACT []

[Term]
id: sgd:S000004184
name: YLR194C
def: "Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004185
name: YLR195C
def: "N-myristoyl transferase; catalyzes the cotranslational\, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC72" EXACT []
synonym: "NMT1" EXACT []
synonym: "glycylpeptide N-tetradecanoyltransferase NMT1" EXACT []

[Term]
id: sgd:S000004186
name: YLR196W
def: "Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PWP1" EXACT []

[Term]
id: sgd:S000004187
name: YLR197W
def: "Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP56" EXACT []
synonym: "SIK1" EXACT []
synonym: "snoRNP complex protein NOP56" EXACT []

[Term]
id: sgd:S000004188
name: YLR198C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004189
name: YLR199C
def: "Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBA1" EXACT []
synonym: "POC1" EXACT []

[Term]
id: sgd:S000004190
name: YLR200W
def: "Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin\, beta-tubulin\, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM1" EXACT []
synonym: "PFD6" EXACT []
synonym: "YKE2" EXACT []

[Term]
id: sgd:S000004191
name: YLR201C
def: "Protein required for ubiquinone biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ9" EXACT []
synonym: "FMP53" EXACT []

[Term]
id: sgd:S000004192
name: YLR202C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004193
name: YLR203C
def: "Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B\, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS51" EXACT []

[Term]
id: sgd:S000004194
name: YLR204W
def: "Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX24" EXACT []
synonym: "QRI5" EXACT []

[Term]
id: sgd:S000004195
name: YLR205C
def: "ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMX1" EXACT []

[Term]
id: sgd:S000004196
name: YLR206W
def: "Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog\, ENT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENT2" EXACT []

[Term]
id: sgd:S000004197
name: YLR207W
def: "ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation \(ERAD\) determinants that engages in lumen to cytosol communication and coordination of ERAD events" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRD3" EXACT []
synonym: "ubiquitin ligase complex subunit HRD3" EXACT []

[Term]
id: sgd:S000004198
name: YLR208W
def: "Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex \(NPC\)\, COPII vesicle coat\, and Seh1-associated \(SEA\) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport\, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery\, including transcription; homologous to human SEC13; abundance increases under DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANU3" EXACT []
synonym: "GTPase-activating protein SEC13" EXACT []
synonym: "SEC13" EXACT []

[Term]
id: sgd:S000004199
name: YLR209C
def: "Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PNP1" EXACT []
synonym: "purine-nucleoside phosphorylase" EXACT []

[Term]
id: sgd:S000004200
name: YLR210W
def: "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2\, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog\, CLB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB4" EXACT []
synonym: "CLB4" EXACT []

[Term]
id: sgd:S000004201
name: YLR211C
def: "Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure \(PAS\) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG38" EXACT []

[Term]
id: sgd:S000004202
name: YLR212C
def: "Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUB4" EXACT []
synonym: "gamma-tubulin" EXACT []

[Term]
id: sgd:S000004203
name: YLR213C
def: "Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly\, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRR1" EXACT []

[Term]
id: sgd:S000004204
name: YLR214W
def: "Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE1" EXACT []

[Term]
id: sgd:S000004205
name: YLR215C
def: "Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC123" EXACT []

[Term]
id: sgd:S000004206
name: YLR216C
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR6" EXACT []
synonym: "CYP40" EXACT []
synonym: "peptidylprolyl isomerase CPR6" EXACT []

[Term]
id: sgd:S000004207
name: YLR217W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004208
name: YLR218C
def: "Twin Cx\(9\)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMC3" EXACT []
synonym: "COA4" EXACT []

[Term]
id: sgd:S000004209
name: YLR219W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSC3" EXACT []

[Term]
id: sgd:S000004210
name: YLR220W
def: "Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants\, which lack the ortholog of mammalian frataxin\, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCC1" EXACT []

[Term]
id: sgd:S000004211
name: YLR221C
def: "Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large \(60S\) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSA3" EXACT []

[Term]
id: sgd:S000004212
name: YLR222C
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP13" EXACT []

[Term]
id: sgd:S000004213
name: YLR223C
def: "Coactivator\, regulates transcription of ribosomal protein \(RP\) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI\, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog\, CRF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IFH1" EXACT []

[Term]
id: sgd:S000004214
name: YLR224W
def: "F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004215
name: YLR225C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog\, YDR222W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004216
name: YLR226W
def: "Cyclin for the Sgv1p \(Bur1p\) protein kinase; Sgv1p and Bur2p comprise the CDK-cyclin BUR kinase complex which is involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain \(CTD\) of the largest subunit of RNA polymerase II \(Rpo21p\); BUR kinase is also involved in the recruitment of Spt6p to the CTD at the onset of transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUR2" EXACT []
synonym: "CST4" EXACT []

[Term]
id: sgd:S000004217
name: YLR227C
def: "Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADY4" EXACT []

[Term]
id: sgd:S000004218
name: YLR228C
def: "Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn\[2\]-Cys\[6\] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog\, UPC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM22" EXACT []

[Term]
id: sgd:S000004219
name: YLR229C
def: "Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC42" EXACT []
synonym: "Rho family GTPase CDC42" EXACT []

[Term]
id: sgd:S000004220
name: YLR230W
def: "Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42/YLR229C gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004221
name: YLR231C
def: "Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNA5" EXACT []
synonym: "kynureninase" EXACT []

[Term]
id: sgd:S000004222
name: YLR232W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004223
name: YLR233C
def: "TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog\, EBS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EST1" EXACT []

[Term]
id: sgd:S000004224
name: YLR234W
def: "DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity stimulated by RPA and Sgs1p-Top2p-Rmi1p; involved in telomere stability and regulation of mitotic recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA topoisomerase 3" EXACT []
synonym: "EDR1" EXACT []
synonym: "TOP3" EXACT []

[Term]
id: sgd:S000004225
name: YLR235C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YLR234W and YLR236C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004226
name: YLR236C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF YLR235C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004227
name: YLR237W
def: "Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside \(acadesine\); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI10" EXACT []
synonym: "THI7" EXACT []

[Term]
id: sgd:S000004228
name: YLR238W
def: "Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p\, Far7p\, Far8p\, Far9p\, and Far11p; potential Cdc28p substrate; FAR10 has a paralog\, VPS64\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR10" EXACT []

[Term]
id: sgd:S000004229
name: YLR239C
def: "Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIP2" EXACT []
synonym: "lipoyl(octanoyl) transferase LIP2" EXACT []

[Term]
id: sgd:S000004230
name: YLR240W
def: "Phosphatidylinositol \(PI\) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized\, with Vps15p\, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END12" EXACT []
synonym: "PEP15" EXACT []
synonym: "STT8" EXACT []
synonym: "VPL7" EXACT []
synonym: "VPS34" EXACT []
synonym: "VPS7" EXACT []
synonym: "VPT29" EXACT []
synonym: "phosphatidylinositol 3-kinase VPS34" EXACT []

[Term]
id: sgd:S000004231
name: YLR241W
def: "Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSC1" EXACT []

[Term]
id: sgd:S000004232
name: YLR242C
def: "Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARV1" EXACT []

[Term]
id: sgd:S000004233
name: YLR243W
def: "Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPN3" EXACT []

[Term]
id: sgd:S000004234
name: YLR244C
def: "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAP1" EXACT []

[Term]
id: sgd:S000004235
name: YLR245C
def: "Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified\, localizes to both the nucleus and cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDD1" EXACT []
synonym: "cytidine deaminase" EXACT []

[Term]
id: sgd:S000004236
name: YLR246W
def: "Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERF2" EXACT []

[Term]
id: sgd:S000004237
name: YLR247C
def: "E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining \(NHEJ\) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "E3 ubiquitin-protein ligase IRC20" EXACT []
synonym: "IRC20" EXACT []

[Term]
id: sgd:S000004238
name: YLR248W
def: "Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM \(calmodulin\) kinases; RCK2 has a paralog\, RCK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLK1" EXACT []
synonym: "CMK3" EXACT []
synonym: "RCK2" EXACT []
synonym: "serine/threonine protein kinase RCK2" EXACT []

[Term]
id: sgd:S000004239
name: YLR249W
def: "Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog\, HEF3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EF-3" EXACT []
synonym: "TEF3" EXACT []
synonym: "YEF3" EXACT []
synonym: "eEF3" EXACT []
synonym: "translation elongation factor EF-3" EXACT []

[Term]
id: sgd:S000004240
name: YLR250W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSP120" EXACT []

[Term]
id: sgd:S000004241
name: YLR251W
def: "Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYM1" EXACT []

[Term]
id: sgd:S000004242
name: YLR252W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene SYM1\, a mitochondrial protein involved in ethanol metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004243
name: YLR253W
def: "Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10\, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase\, ADCK1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCP2" EXACT []

[Term]
id: sgd:S000004244
name: YLR254C
def: "Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDL1" EXACT []

[Term]
id: sgd:S000004245
name: YLR255C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004246
name: YLR256W
def: "Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYP1" EXACT []
synonym: "HAP1" EXACT []

[Term]
id: sgd:S000004247
name: YLR257W
def: "Protein of unknown function; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004248
name: YLR258W
def: "Glycogen synthase; expression induced by glucose limitation\, nitrogen starvation\, heat shock\, and stationary phase; activity regulated by cAMP-dependent\, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog\, GSY1\, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSY2" EXACT []
synonym: "glycogen (starch) synthase GSY2" EXACT []

[Term]
id: sgd:S000004249
name: YLR259C
def: "Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPN60" EXACT []
synonym: "HSP60" EXACT []
synonym: "MIF4" EXACT []
synonym: "MNA2" EXACT []
synonym: "chaperone ATPase HSP60" EXACT []

[Term]
id: sgd:S000004250
name: YLR260W
def: "Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates\, which function as signaling molecules; LCB5 has a paralog\, LCB4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCB5" EXACT []
synonym: "sphinganine kinase LCB5" EXACT []

[Term]
id: sgd:S000004251
name: YLR261C
def: "Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS63" EXACT []

[Term]
id: sgd:S000004252
name: YLR262C
def: "Rab family GTPase; Ras-like GTP binding protein involved in the secretory pathway\, required for fusion of endosome-derived vesicles with the late Golgi\, maturation of the vacuolar carboxypeptidase Y; resides temporarily at the Golgi\, dissociates into cytosol upon arrival of the Rab GTPaseYpt32p\, which also functions in the late Golgi; Golgi-localized form is bound to GTP\, while cytosolic form is GDP-bound; homolog of the mammalian Rab6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT6" EXACT []
synonym: "YPT6" EXACT []

[Term]
id: sgd:S000004253
name: YLR263W
def: "Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RED1" EXACT []

[Term]
id: sgd:S000004254
name: YLR264W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S28\, no bacterial homolog; has an extraribosomal function in autoregulation\, in which Rps28Bp binds to a decapping complex via Edc3p\, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog\, RPS28A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS28B" EXACT []
synonym: "RPS33B" EXACT []
synonym: "S28B" EXACT []
synonym: "S28e" EXACT []
synonym: "S33B" EXACT []
synonym: "YS27" EXACT []
synonym: "ribosomal 40S subunit protein S28B" EXACT []

[Term]
id: sgd:S000004255
name: YLR265C
def: "Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIF2" EXACT []
synonym: "NEJ1" EXACT []

[Term]
id: sgd:S000004256
name: YLR266C
def: "Transcription factor; targets include ATP-binding cassette \(ABC\) transporters\, major facilitator superfamily transporters\, and other genes involved in the pleiotropic drug resistance \(PDR\) phenomenon; PDR8 has a paralog\, YRR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDR8" EXACT []

[Term]
id: sgd:S000004257
name: YLR267W
def: "Protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOP2" EXACT []

[Term]
id: sgd:S000004258
name: YLR268W
def: "R-SNARE protein; assembles into SNARE complex with Bet1p\, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC22" EXACT []
synonym: "SLY2" EXACT []
synonym: "SNAP receptor SEC22" EXACT []
synonym: "TS26" EXACT []
synonym: "TSL26" EXACT []

[Term]
id: sgd:S000004259
name: YLR269C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004260
name: YLR270W
def: "Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation\, contains pyrophosphatase activity and a HIT \(histidine triad\) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog\, DCS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCS1" EXACT []
synonym: "DcpS" EXACT []

[Term]
id: sgd:S000004261
name: YLR271W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004262
name: YLR272C
def: "Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation\, chromosome segregation\, chromatin binding of condensin\, tRNA gene clustering at the nucleolus\, and silencing at the mating type locus; required for replication slow zone \(RSZ\) breakage following Mec1p inactivation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOC7" EXACT []
synonym: "YCS4" EXACT []

[Term]
id: sgd:S000004263
name: YLR273C
def: "Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog\, GAC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIG1" EXACT []
synonym: "protein phosphatase regulator PIG1" EXACT []

[Term]
id: sgd:S000004264
name: YLR274W
def: "Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOB1" EXACT []
synonym: "CDC46" EXACT []
synonym: "MCM DNA helicase complex subunit MCM5" EXACT []
synonym: "MCM5" EXACT []

[Term]
id: sgd:S000004265
name: YLR275W
def: "Core Sm protein Sm D2; part of heteroheptameric complex \(with Smb1p\, Smd1p\, Smd3p\, Sme1p\, Smx3p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm D2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMD2" EXACT []
synonym: "Sm D2" EXACT []

[Term]
id: sgd:S000004266
name: YLR276C
def: "DEAD-box protein required for 27S rRNA processing; exhibits DNA\, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP9" EXACT []

[Term]
id: sgd:S000004267
name: YLR277C
def: "Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing\, splicing\, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog\, SYC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRR5" EXACT []
synonym: "YSH1" EXACT []

[Term]
id: sgd:S000004268
name: YLR278C
def: "Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of \[URE3\]; YLR278C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004269
name: YLR279W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004270
name: YLR280C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004271
name: YLR281C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YLR281C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004272
name: YLR282C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004273
name: YLR283W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YLR283W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004274
name: YLR284C
def: "Peroxisomal delta3\,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA\, essential for the beta-oxidation of unsaturated fatty acids\, oleate-induced; ECI1 has a paralog\, DCI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECI1" EXACT []
synonym: "dodecenoyl-CoA isomerase" EXACT []

[Term]
id: sgd:S000004275
name: YLR285W
def: "S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NNT1" EXACT []

[Term]
id: sgd:S000004276
name: YLR286C
def: "Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTS1" EXACT []
synonym: "SCW2" EXACT []

[Term]
id: sgd:S000004277
name: YLR287C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004278
name: YLR287C-A
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S30\, no bacterial homolog; RPS30A has a paralog\, RPS30B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS30A" EXACT []
synonym: "S30A" EXACT []
synonym: "S30e" EXACT []
synonym: "ribosomal 40S subunit protein S30A" EXACT []

[Term]
id: sgd:S000004279
name: YLR288C
def: "DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex \(Rad17p-Mec3p-Ddc1p\) that forms a sliding clamp\, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEC3" EXACT []
synonym: "PIP3" EXACT []
synonym: "PSO9" EXACT []

[Term]
id: sgd:S000004280
name: YLR289W
def: "Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTPase GUF1" EXACT []
synonym: "GUF1" EXACT []

[Term]
id: sgd:S000004281
name: YLR290C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004282
name: YLR291C
def: "Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD7" EXACT []
synonym: "translation initiation factor eIF2B subunit beta" EXACT []

[Term]
id: sgd:S000004283
name: YLR292C
def: "Non-essential subunit of Sec63 complex; with Sec61 complex\, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p\, Sec62p\, and Sec66p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC67" EXACT []
synonym: "SEC72" EXACT []
synonym: "SIM2" EXACT []
synonym: "Sec63 complex subunit SEC72" EXACT []

[Term]
id: sgd:S000004284
name: YLR293C
def: "Ran GTPase; GTP binding protein \(mammalian Ranp homolog\) involved in the maintenance of nuclear organization\, RNA processing and transport; regulated by Srm1p\, Rna1p\, Yrb1p\, Yrb2p\, Yrp4p\, Yrb30p\, Cse1p and Kap95p; GSP1 has a paralog\, GSP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNR1" EXACT []
synonym: "CST17" EXACT []
synonym: "GSP1" EXACT []
synonym: "Ran GTPase GSP1" EXACT []

[Term]
id: sgd:S000004285
name: YLR294C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004286
name: YLR295C
def: "Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP14" EXACT []
synonym: "F1F0 ATP synthase subunit h" EXACT []

[Term]
id: sgd:S000004287
name: YLR296W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004288
name: YLR297W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog\, YOR186W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004289
name: YLR298C
def: "Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein\, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "U1-C" EXACT []
synonym: "U1C" EXACT []
synonym: "YHC1" EXACT []

[Term]
id: sgd:S000004290
name: YLR299W
def: "Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIS2" EXACT []
synonym: "ECM38" EXACT []
synonym: "gamma-glutamyltransferase" EXACT []

[Term]
id: sgd:S000004291
name: YLR300W
def: "Major exo-1\,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog\, SPR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BGL1" EXACT []
synonym: "EXG1" EXACT []
synonym: "SCW6" EXACT []

[Term]
id: sgd:S000004292
name: YLR301W
def: "Protein of unknown function that interacts with Sec72p and Hrr25p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRI1" EXACT []

[Term]
id: sgd:S000004293
name: YLR302C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004294
name: YLR303W
def: "O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET15" EXACT []
synonym: "MET17" EXACT []
synonym: "MET25" EXACT []
synonym: "bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17" EXACT []

[Term]
id: sgd:S000004295
name: YLR304C
def: "Aconitase; required for the tricarboxylic acid \(TCA\) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACO1" EXACT []
synonym: "GLU1" EXACT []
synonym: "aconitate hydratase ACO1" EXACT []

[Term]
id: sgd:S000004296
name: YLR305C
def: "Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology\, cell wall integrity\, and actin cytoskeleton organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-phosphatidylinositol 4-kinase STT4" EXACT []
synonym: "STT4" EXACT []

[Term]
id: sgd:S000004297
name: YLR306W
def: "Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein\, to other proteins; related to E2 ubiquitin-conjugating enzymes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEDD8-conjugating protein UBC12" EXACT []
synonym: "UBC12" EXACT []

[Term]
id: sgd:S000004298
name: YLR307W
def: "Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component\, chitosan; required for proper rigidity of the ascospore wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDA1" EXACT []
synonym: "chitin deacetylase CDA1" EXACT []

[Term]
id: sgd:S000004299
name: YLR308W
def: "Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component\, chitosan; required for proper rigidity of the ascospore wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDA2" EXACT []
synonym: "chitin deacetylase CDA2" EXACT []

[Term]
id: sgd:S000004300
name: YLR309C
def: "Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi\, contains a Golgi-localization \(GRIP\) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMH1" EXACT []
synonym: "SYS3" EXACT []

[Term]
id: sgd:S000004301
name: YLR310C
def: "Membrane bound guanine nucleotide exchange factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; a membrane bound guanine nucleotide exchange factor is also known as a GEF or GDP-release factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC25" EXACT []
synonym: "CDC25'" EXACT []
synonym: "CTN1" EXACT []
synonym: "Ras family guanine nucleotide exchange factor CDC25" EXACT []

[Term]
id: sgd:S000004302
name: YLR311C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004303
name: YLR312C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "QNQ1" EXACT []

[Term]
id: sgd:S000004304
name: YLR312W-A
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL15" EXACT []
synonym: "YmL15" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL15" EXACT []

[Term]
id: sgd:S000004305
name: YLR313C
def: "Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner\, interacts with MAPKKs Mkk1p\, Mkk2p\, and Ste7p; SPH1 has a paralog\, SPA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPH1" EXACT []
synonym: "YLR312C-B" EXACT []

[Term]
id: sgd:S000004306
name: YLR314C
def: "Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC3" EXACT []
synonym: "septin CDC3" EXACT []

[Term]
id: sgd:S000004307
name: YLR315W
def: "Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NKP2" EXACT []

[Term]
id: sgd:S000004308
name: YLR316C
def: "Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAD3" EXACT []

[Term]
id: sgd:S000004309
name: YLR317W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004310
name: YLR318W
def: "Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity\, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EST2" EXACT []
synonym: "TERT" EXACT []

[Term]
id: sgd:S000004311
name: YLR319C
def: "Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor \(NPF\) for formins Bni1p and Bnr1p; a triple helical coiled-coil domain in the C-terminal region interacts with Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIP3" EXACT []
synonym: "BUD6" EXACT []

[Term]
id: sgd:S000004312
name: YLR320W
def: "Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork\, such as the fork-pausing complex and leading strand polymerase\, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMS22" EXACT []
synonym: "SLM2" EXACT []

[Term]
id: sgd:S000004313
name: YLR321C
def: "Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFH1" EXACT []

[Term]
id: sgd:S000004314
name: YLR322W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS65" EXACT []

[Term]
id: sgd:S000004315
name: YLR323C
def: "General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC24" EXACT []

[Term]
id: sgd:S000004316
name: YLR324W
def: "Peroxisomal integral membrane protein; involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog\, PEX31\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX30" EXACT []

[Term]
id: sgd:S000004317
name: YLR325C
def: "Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L38" EXACT []
synonym: "L38e" EXACT []
synonym: "RPL38" EXACT []
synonym: "ribosomal 60S subunit protein L38" EXACT []

[Term]
id: sgd:S000004318
name: YLR326W
def: "Putative protein of unknown function; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004319
name: YLR327C
def: "Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog\, STF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF9" EXACT []
synonym: "SFL2" EXACT []
synonym: "TMA10" EXACT []

[Term]
id: sgd:S000004320
name: YLR328W
def: "Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis\, including the de novo\, NAD\(+\) salvage\, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog\, NMA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NMA1" EXACT []
synonym: "nicotinamide-nucleotide adenylyltransferase NMA1" EXACT []

[Term]
id: sgd:S000004321
name: YLR329W
def: "Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REC102" EXACT []

[Term]
id: sgd:S000004322
name: YLR330W
def: "Component of the exomer complex; exomer also contains Csh6p\, Bch1p\, Bch2p\, and Bud7p and is involved in export of selected proteins\, such as chitin synthase Chs3p\, from the Golgi to the plasma membrane; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAL3" EXACT []
synonym: "CHS5" EXACT []

[Term]
id: sgd:S000004323
name: YLR331C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JIP3" EXACT []

[Term]
id: sgd:S000004324
name: YLR332W
def: "O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p\, a guanine nucleotide exchange factor for Rho1p\, and with cell integrity pathway protein Zeo1p; MID2 has a paralog\, MTL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAI1" EXACT []
synonym: "MID2" EXACT []

[Term]
id: sgd:S000004325
name: YLR333C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S25\, no bacterial homolog; RPS25B has a paralog\, RPS25A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS25B" EXACT []
synonym: "S25B" EXACT []
synonym: "S25e" EXACT []
synonym: "S31B" EXACT []
synonym: "YS23" EXACT []
synonym: "ribosomal 40S subunit protein S25B" EXACT []
synonym: "rp45" EXACT []

[Term]
id: sgd:S000004326
name: YLR334C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004327
name: YLR335W
def: "Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP2" EXACT []
synonym: "nucleoporin NUP2" EXACT []

[Term]
id: sgd:S000004328
name: YLR336C
def: "Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGD1" EXACT []

[Term]
id: sgd:S000004329
name: YLR337C
def: "Verprolin\, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein \(WASP\)-interacting protein \(WIP\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END5" EXACT []
synonym: "MDP2" EXACT []
synonym: "VRP1" EXACT []
synonym: "YLR337W" EXACT []

[Term]
id: sgd:S000004330
name: YLR338W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI9" EXACT []

[Term]
id: sgd:S000004331
name: YLR339C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004332
name: YLR340W
def: "Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A0" EXACT []
synonym: "L10E" EXACT []
synonym: "P0" EXACT []
synonym: "RPL10E" EXACT []
synonym: "RPP0" EXACT []
synonym: "ribosomal protein P0" EXACT []

[Term]
id: sgd:S000004333
name: YLR341W
def: "Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO77" EXACT []

[Term]
id: sgd:S000004334
name: YLR342W
def: "Catalytic subunit of 1\,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog\, GSC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1" EXACT []
synonym: "3-beta-D-glucan synthase" EXACT []
synonym: "CND1" EXACT []
synonym: "CWH53" EXACT []
synonym: "ETG1" EXACT []
synonym: "FKS1" EXACT []
synonym: "GSC1" EXACT []
synonym: "PBR1" EXACT []

[Term]
id: sgd:S000004335
name: YLR343W
def: "1\,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAS2" EXACT []

[Term]
id: sgd:S000004336
name: YLR344W
def: "Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog\, RPL26B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L24" EXACT []
synonym: "L26A" EXACT []
synonym: "L33A" EXACT []
synonym: "RPL26A" EXACT []
synonym: "YL33" EXACT []
synonym: "ribosomal 60S subunit protein L26A" EXACT []

[Term]
id: sgd:S000004337
name: YLR345W
def: "Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase" EXACT []
synonym: "bifunctional fructose-2" EXACT []

[Term]
id: sgd:S000004338
name: YLR346C
def: "Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance\, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog\, YGR035C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004339
name: YLR347C
def: "Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP95" EXACT []
synonym: "RSL1" EXACT []

[Term]
id: sgd:S000004340
name: YLR348C
def: "Mitochondrial dicarboxylate carrier; integral membrane protein\, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane\, transports cytoplasmic dicarboxylates into the mitochondrial matrix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIC1" EXACT []

[Term]
id: sgd:S000004341
name: YLR349W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004342
name: YLR350W
def: "Protein that mediates sphingolipid homeostasis; evolutionarily conserved\, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog\, ORM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORM2" EXACT []

[Term]
id: sgd:S000004343
name: YLR351C
def: "Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIT3" EXACT []

[Term]
id: sgd:S000004344
name: YLR352W
def: "Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004345
name: YLR353W
def: "Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern\, and bud at the proximal pole; BUD8 has a paralog\, BUD9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD8" EXACT []

[Term]
id: sgd:S000004346
name: YLR354C
def: "Transaldolase\, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog\, NQM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAL1" EXACT []
synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1" EXACT []

[Term]
id: sgd:S000004347
name: YLR355C
def: "Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILV5" EXACT []
synonym: "ketol-acid reductoisomerase" EXACT []

[Term]
id: sgd:S000004348
name: YLR356W
def: "Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi\, but not in higher eukaryotes; ATG33 has a paralog\, SCM4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG33" EXACT []

[Term]
id: sgd:S000004349
name: YLR357W
def: "Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog\, RSC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC2" EXACT []

[Term]
id: sgd:S000004350
name: YLR358C
def: "Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004351
name: YLR359W
def: "Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE13" EXACT []
synonym: "BRA1" EXACT []
synonym: "BRA8" EXACT []
synonym: "adenylosuccinase ADE13" EXACT []

[Term]
id: sgd:S000004352
name: YLR360W
def: "Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y \(CPY\) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate \(PtdIns3P\) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPL17" EXACT []
synonym: "VPS38" EXACT []

[Term]
id: sgd:S000004353
name: YLR361C
def: "Phosphoesterase; involved in downregulation of the unfolded protein response \(UPR\)\, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCR2" EXACT []

[Term]
id: sgd:S000004354
name: YLR362W
def: "Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p\, and the high osmolarity response pathway\, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE11" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase STE11" EXACT []

[Term]
id: sgd:S000004355
name: YLR363C
def: "Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p\, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NMD4" EXACT []

[Term]
id: sgd:S000004356
name: YLR364W
def: "Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX8" EXACT []
synonym: "glutathione-disulfide reductase GRX8" EXACT []

[Term]
id: sgd:S000004357
name: YLR365W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004358
name: YLR366W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004359
name: YLR367W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog\, RPS22A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS22B" EXACT []
synonym: "S22B" EXACT []
synonym: "S24B" EXACT []
synonym: "S8" EXACT []
synonym: "YS22" EXACT []
synonym: "ribosomal 40S subunit protein S22B" EXACT []
synonym: "rp50" EXACT []

[Term]
id: sgd:S000004360
name: YLR368W
def: "F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSG1" EXACT []
synonym: "MDM30" EXACT []
synonym: "SCF ubiquitin ligase complex subunit MDM30" EXACT []

[Term]
id: sgd:S000004361
name: YLR369W
def: "Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis\, and for maturation of Yfh1p\, which is a homolog of human frataxin implicated in Friedreich's ataxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family ATPase SSQ1" EXACT []
synonym: "SSC2" EXACT []
synonym: "SSH1" EXACT []
synonym: "SSQ1" EXACT []

[Term]
id: sgd:S000004362
name: YLR370C
def: "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC18" EXACT []

[Term]
id: sgd:S000004363
name: YLR371W
def: "GDP/GTP exchange factor \(GEF\) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1\, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog\, ROM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROM2" EXACT []
synonym: "Rho family guanine nucleotide exchange factor ROM2" EXACT []

[Term]
id: sgd:S000004364
name: YLR372W
def: "Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APA1" EXACT []
synonym: "ELO3" EXACT []
synonym: "SRE1" EXACT []
synonym: "SUR4" EXACT []
synonym: "VBM1" EXACT []
synonym: "fatty acid elongase ELO3" EXACT []

[Term]
id: sgd:S000004365
name: YLR373C
def: "Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1\,6-bisphosphatase \(FBPase\) degradation; involved in FBPase transport from the cytosol to Vid \(vacuole import and degradation\) vesicles; VID22 has a paralog\, ENV11\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VID22" EXACT []

[Term]
id: sgd:S000004366
name: YLR374C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004367
name: YLR375W
def: "Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog\, STP4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STP3" EXACT []

[Term]
id: sgd:S000004368
name: YLR376C
def: "Component of Shu complex \(aka PCSS complex\); Shu complex also includes Shu1\, Csm2\, Shu2\, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSY3" EXACT []

[Term]
id: sgd:S000004369
name: YLR377C
def: "Fructose-1\,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway\, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-bisphosphate 1-phosphatase" EXACT []
synonym: "ACN8" EXACT []
synonym: "FBP1" EXACT []
synonym: "fructose 1" EXACT []

[Term]
id: sgd:S000004370
name: YLR378C
def: "Conserved ER protein translocation channel; essential subunit of Sec61 complex \(Sec61p\, Sbh1p\, and Sss1p\); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER\, ERAD of soluble substrates\, and misfolded soluble protein export from the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC61" EXACT []
synonym: "translocon subunit SEC61" EXACT []

[Term]
id: sgd:S000004371
name: YLR379W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004372
name: YLR380W
def: "Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSR1" EXACT []
synonym: "SFH2" EXACT []

[Term]
id: sgd:S000004373
name: YLR381W
def: "Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-I and fission yeast mis6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL3" EXACT []
synonym: "CTF3" EXACT []

[Term]
id: sgd:S000004374
name: YLR382C
def: "Mitochondrial leucyl-tRNA synthetase; also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LeuRS" EXACT []
synonym: "MSL1" EXACT []
synonym: "NAM2" EXACT []
synonym: "leucine--tRNA ligase NAM2" EXACT []

[Term]
id: sgd:S000004375
name: YLR383W
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA repair protein SMC6" EXACT []
synonym: "RHC18" EXACT []
synonym: "SMC6" EXACT []

[Term]
id: sgd:S000004376
name: YLR384C
def: "Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP\, mutations in which cause familial dysautonomia \(FD\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP1" EXACT []
synonym: "Elongator subunit IKI3" EXACT []
synonym: "IKI3" EXACT []
synonym: "KTI7" EXACT []
synonym: "TOT1" EXACT []

[Term]
id: sgd:S000004377
name: YLR385C
def: "Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AWS1" EXACT []
synonym: "SWC7" EXACT []

[Term]
id: sgd:S000004378
name: YLR386W
def: "Enzyme regulator; involved in synthesis of phosphatidylinositol 3\,5-bisphosphate\, in control of trafficking of some proteins to the vacuole lumen via the MVB\, and in maintenance of vacuole size and acidity; binds negative \(Fig4p\) and positive \(Fab1p\) regulators of PtdIns\(3\,5\)P\(2\) to control endolysosome function; similar to mammalian Vac14p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAC14" EXACT []

[Term]
id: sgd:S000004379
name: YLR387C
def: "Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REH1" EXACT []

[Term]
id: sgd:S000004380
name: YLR388W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog\, RPS29B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS29A" EXACT []
synonym: "S14" EXACT []
synonym: "S29A" EXACT []
synonym: "S36A" EXACT []
synonym: "YS29" EXACT []
synonym: "YS29A" EXACT []
synonym: "ribosomal 40S subunit protein S29A" EXACT []

[Term]
id: sgd:S000004381
name: YLR389C
def: "Metalloprotease; involved in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family; homolog Axl1p is also involved in processing of pro-a-factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE23" EXACT []

[Term]
id: sgd:S000004382
name: YLR390W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM19" EXACT []

[Term]
id: sgd:S000004384
name: YLR392C
def: "Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein \(GFP\)-fusion protein localizes it to the cytoplasm; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART10" EXACT []

[Term]
id: sgd:S000004385
name: YLR393W
def: "Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP10" EXACT []

[Term]
id: sgd:S000004386
name: YLR394W
def: "SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST9" EXACT []
synonym: "SUMO ligase CST9" EXACT []
synonym: "ZIP3" EXACT []

[Term]
id: sgd:S000004387
name: YLR395C
def: "Subunit VIII of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX8" EXACT []
synonym: "cytochrome c oxidase subunit VIII" EXACT []

[Term]
id: sgd:S000004388
name: YLR396C
def: "ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting\, vesicle docking\, and fusion at the vacuole; binds to SNARE domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS14" EXACT []
synonym: "MET27" EXACT []
synonym: "PEP14" EXACT []
synonym: "SLP1" EXACT []
synonym: "VAM5" EXACT []
synonym: "VPL25" EXACT []
synonym: "VPS33" EXACT []
synonym: "VPT33" EXACT []
synonym: "tethering complex ATP-binding subunit VPS33" EXACT []

[Term]
id: sgd:S000004389
name: YLR397C
def: "ATPase of the CDC48/PAS1/SEC18 \(AAA\) family\, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase AFG2" EXACT []
synonym: "AFG2" EXACT []
synonym: "DRG1" EXACT []

[Term]
id: sgd:S000004390
name: YLR398C
def: "Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog\, SKIV2L\, causes Syndromic diarrhea/Trichohepatoenteric \(SD/THE\) syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKI complex RNA helicase subunit SKI2" EXACT []
synonym: "SKI2" EXACT []

[Term]
id: sgd:S000004391
name: YLR399C
def: "Protein involved in transcription initiation; functions at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p; BDF1 has a paralog\, BDF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BDF1" EXACT []
synonym: "chromatin-binding protein BDF1" EXACT []

[Term]
id: sgd:S000004392
name: YLR400W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004393
name: YLR401C
def: "Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p\, Dus1p\, and Dus4p; contains a consensus oleate response element \(ORE\) in its promoter region; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUS3" EXACT []

[Term]
id: sgd:S000004394
name: YLR402W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004395
name: YLR403W
def: "Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress\, G2/M transitions during mitotic cell cycle and DNA-damage response\, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger\, ChIP localization data\, and protein-binding microarray \(PBM\) data\, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the \[ISP+\] prion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFP1" EXACT []
synonym: "[ISP(+)]" EXACT []
synonym: "[ISP+]" EXACT []
synonym: "zinc-coordinating transcription factor SFP1" EXACT []

[Term]
id: sgd:S000004396
name: YLR404W
def: "Seipin protein; involved in lipid droplet morphology\, number\, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FLD1" EXACT []
synonym: "SEI1" EXACT []

[Term]
id: sgd:S000004397
name: YLR405W
def: "Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p\, Dus1p\, and Dus3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUS4" EXACT []

[Term]
id: sgd:S000004398
name: YLR406C
def: "Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31\, no bacterial homolog; RPL31B has a paralog\, RPL31A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L31B" EXACT []
synonym: "L31e" EXACT []
synonym: "L34B" EXACT []
synonym: "RPL31B" EXACT []
synonym: "YL28" EXACT []
synonym: "ribosomal 60S subunit protein L31B" EXACT []

[Term]
id: sgd:S000004399
name: YLR407W
def: "Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004400
name: YLR408C
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein \(GFP\)-fusion protein localizes to the endosome; YLR408C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLB1" EXACT []
synonym: "BLS1" EXACT []

[Term]
id: sgd:S000004401
name: YLR409C
def: "Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP21" EXACT []

[Term]
id: sgd:S000004402
name: YLR410W
def: "Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate \(IP7\) production is important for phosphate signaling; involved in cortical actin cytoskeleton function\, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol hexakisphosphate is also known as IP6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VIP1" EXACT []
synonym: "inositol polyphosphate kinase VIP1" EXACT []

[Term]
id: sgd:S000004403
name: YLR411W
def: "High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTR3" EXACT []

[Term]
id: sgd:S000004404
name: YLR412W
def: "Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BER1" EXACT []

[Term]
id: sgd:S000004405
name: YLR413W
def: "Putative protein of unknown function; not an essential gene; YLR413W has a paralog\, FAT3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INA1" EXACT []

[Term]
id: sgd:S000004406
name: YLR414C
def: "Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUN1" EXACT []

[Term]
id: sgd:S000004407
name: YLR415C
def: "Putative protein of unknown function; YLR415C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004408
name: YLR416C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004409
name: YLR417W
def: "Component of the ESCRT-II complex; contains the GLUE \(GRAM Like Ubiquitin binding in EAP45\) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin \(Htt\) aggregates in yeast" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-II subunit protein VPS36" EXACT []
synonym: "GRD12" EXACT []
synonym: "VAC3" EXACT []
synonym: "VPL11" EXACT []
synonym: "VPS36" EXACT []

[Term]
id: sgd:S000004410
name: YLR418C
def: "Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes\, modification of some histones\, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on \(GLRO\) assay; protein abundance increases in response to DNA replication stress; human homologue\, parafibromin\, is a tumour suppressor linked to breast\, renal and gastric cancers" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC73" EXACT []

[Term]
id: sgd:S000004411
name: YLR419W
def: "Putative helicase with limited sequence similarity to human Rb protein; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative helicase" EXACT []

[Term]
id: sgd:S000004412
name: YLR420W
def: "Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines\, converting carbamoyl-L-aspartate into dihydroorotate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URA4" EXACT []
synonym: "dihydroorotase" EXACT []

[Term]
id: sgd:S000004413
name: YLR421C
def: "Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN13" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN13" EXACT []

[Term]
id: sgd:S000004414
name: YLR422W
def: "Protein of unknown function with similarity to human DOCK proteins; interacts with Ino4p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm\, YLR422W is not an essential protein; DOCK proteins act as guanine nucleotide exchange factors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004415
name: YLR423C
def: "Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53\, which inhibits autophagy in human cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG17" EXACT []
synonym: "ATG17" EXACT []
synonym: "protein kinase regulatory subunit ATG17" EXACT []

[Term]
id: sgd:S000004416
name: YLR424W
def: "Essential protein that forms a dimer with Ntr2p; also forms a trimer\, with Ntr2p and Prp43p\, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCF8" EXACT []
synonym: "NTR1" EXACT []
synonym: "SPP382" EXACT []

[Term]
id: sgd:S000004417
name: YLR425W
def: "Guanine nucleotide exchange factor \(GEF\) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rho family guanine nucleotide exchange factor TUS1" EXACT []
synonym: "SOP10" EXACT []
synonym: "TUS1" EXACT []

[Term]
id: sgd:S000004418
name: YLR426W
def: "Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA5" EXACT []

[Term]
id: sgd:S000004419
name: YLR427W
def: "Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAG2" EXACT []

[Term]
id: sgd:S000004420
name: YLR428C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004421
name: YLR429W
def: "Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRN1" EXACT []

[Term]
id: sgd:S000004422
name: YLR430W
def: "Presumed helicase and subunit of the Nrd1 complex \(Nrd1p-Nab3p-Sen1p\); complex interacts with the exosome to mediate 3' end formation of some mRNAs\, snRNAs\, snoRNAs\, and CUTs; has a separate role in coordinating DNA replication with transcription\, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin\, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIK3" EXACT []
synonym: "NRD2" EXACT []
synonym: "SEN1" EXACT []
synonym: "putative DNA/RNA helicase SEN1" EXACT []

[Term]
id: sgd:S000004423
name: YLR431C
def: "Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting \(Cvt\) pathway and efficient macroautophagy; cycles between the phagophore assembly site \(PAS\) and non-PAS locations; forms a complex with Atg9p and Atg27p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG23" EXACT []
synonym: "CVT23" EXACT []

[Term]
id: sgd:S000004424
name: YLR432W
def: "Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae\, constitutively expressed; IMD3 has a paralog\, IMD4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMD3" EXACT []
synonym: "IMP dehydrogenase IMD3" EXACT []

[Term]
id: sgd:S000004425
name: YLR433C
def: "Calcineurin A; one isoform \(the other is Cmp2p\) of the catalytic subunit of calcineurin\, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p \(a stress-response transcription factor\)\, the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog\, CMP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMP1" EXACT []
synonym: "CNA1" EXACT []
synonym: "calcineurin catalytic subunit A" EXACT []

[Term]
id: sgd:S000004426
name: YLR434C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004427
name: YLR435W
def: "Protein with a potential role in pre-rRNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSR2" EXACT []

[Term]
id: sgd:S000004428
name: YLR436C
def: "Putative protein of unknown function; may play a role in cell wall biosynthesis\, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM30" EXACT []

[Term]
id: sgd:S000004429
name: YLR437C
def: "Protein that regulates nuclear localization of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog\, SML1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIF1" EXACT []

[Term]
id: sgd:S000004430
name: YLR438W
def: "L-ornithine transaminase \(OTAse\); catalyzes the second step of arginine degradation\, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAR2" EXACT []
synonym: "cargB" EXACT []
synonym: "ornithine-oxo-acid transaminase" EXACT []

[Term]
id: sgd:S000004431
name: YLR439W
def: "Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL4" EXACT []
synonym: "YmL4" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL4" EXACT []

[Term]
id: sgd:S000004432
name: YLR440C
def: "Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSL3" EXACT []
synonym: "SEC39" EXACT []

[Term]
id: sgd:S000004433
name: YLR441C
def: "Ribosomal protein 10 \(rp10\) of the small \(40S\) subunit; homologous to mammalian ribosomal protein S3A\, no bacterial homolog; RPS1A has a paralog\, RPS1B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RP10A" EXACT []
synonym: "RPS1A" EXACT []
synonym: "S1A" EXACT []
synonym: "S1e" EXACT []
synonym: "ribosomal 40S subunit protein S1A" EXACT []
synonym: "rp10A" EXACT []

[Term]
id: sgd:S000004434
name: YLR442C
def: "Silencing protein; interacts with Sir2p\, Sir4p\, and histone H3 and H4 tails to establish transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus \(residues 840-978\) assumes variant winged helix-turn-helix \(wH\) fold that mediates homodimerization\, which is critical for holo-SIR complex loading; SIR3 has a paralog\, ORC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMT1" EXACT []
synonym: "MAR2" EXACT []
synonym: "SIR3" EXACT []
synonym: "STE8" EXACT []
synonym: "chromatin-silencing protein SIR3" EXACT []

[Term]
id: sgd:S000004435
name: YLR443W
def: "Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM7" EXACT []
synonym: "ZRG15" EXACT []

[Term]
id: sgd:S000004436
name: YLR444C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004437
name: YLR445W
def: "Protein involved in meiotic crossing over; component of the Synaptonemal Complex \(SC\) along with Ecm11p; required for the efficient loading of the SC transverse filament protein\, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GMC2" EXACT []

[Term]
id: sgd:S000004438
name: YLR446W
def: "Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "hexokinase" EXACT []

[Term]
id: sgd:S000004439
name: YLR447C
def: "Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase \(V-ATPase\) has five subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V0 sector ATPase subunit d" EXACT []
synonym: "VMA6" EXACT []

[Term]
id: sgd:S000004440
name: YLR448W
def: "Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6\, no bacterial homolog; RPL6B has a paralog\, RPL6A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L17B" EXACT []
synonym: "L6B" EXACT []
synonym: "L6e" EXACT []
synonym: "RPL6B" EXACT []
synonym: "YL16" EXACT []
synonym: "ribosomal 60S subunit protein L6B" EXACT []
synonym: "rp18" EXACT []

[Term]
id: sgd:S000004441
name: YLR449W
def: "Peptidyl-prolyl cis-trans isomerase \(PPIase\); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4\, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA\, and repressor activity is dependent on PPIase activity; FPR4 has a paralog\, FPR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FPR4" EXACT []
synonym: "peptidylprolyl isomerase FPR4" EXACT []

[Term]
id: sgd:S000004442
name: YLR450W
def: "HMG-CoA reductase; converts HMG-CoA to mevalonate\, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress; HMG2 has a paralog\, HMG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMG2" EXACT []
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) HMG2" EXACT []

[Term]
id: sgd:S000004443
name: YLR451W
def: "Zinc-knuckle transcription factor\, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate\, an intermediate in leucine biosynthesis that accumulates during leucine starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEU3" EXACT []
synonym: "leucine-responsive transcriptional regulator LEU3" EXACT []

[Term]
id: sgd:S000004444
name: YLR452C
def: "GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS \(regulator of G-protein signaling\) family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTPase-activating protein SST2" EXACT []
synonym: "SST2" EXACT []

[Term]
id: sgd:S000004445
name: YLR453C
def: "Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a paralog\, ORC4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIF2" EXACT []

[Term]
id: sgd:S000004446
name: YLR454W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP27" EXACT []

[Term]
id: sgd:S000004447
name: YLR455W
def: "Component of the NuA3b histone acetyltransferase complex; regulates interaction between NuA3b and H3K36me3 at the transcribed regions of genes; contains PWWP domain; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\); protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDP3" EXACT []

[Term]
id: sgd:S000004448
name: YLR456W
def: "Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin\, cycloheximide and H2O2; YLR456W has a paralog\, YPR172W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "pyridoxal 5'-phosphate synthase" EXACT []

[Term]
id: sgd:S000004449
name: YLR457C
def: "Spindle pole body \(SPB\) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog\, YPR174C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NBP1" EXACT []

[Term]
id: sgd:S000004450
name: YLR458W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1/YLR457C gene required for mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004451
name: YLR459W
def: "GPI transamidase subunit; involved in attachment of glycosylphosphatidylinositol \(GPI\) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC91" EXACT []
synonym: "GAB1" EXACT []

[Term]
id: sgd:S000004452
name: YLR460C
def: "Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004453
name: YLR461W
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU4" EXACT []
synonym: "seripauperin PAU4" EXACT []

[Term]
id: sgd:S000004454
name: YLR462W
def: "Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004455
name: YLR463C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004456
name: YLR464W
def: "Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004457
name: YLR465C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC3" EXACT []

[Term]
id: sgd:S000004458
name: YLR466W
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 4" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-4" EXACT []

[Term]
id: sgd:S000004459
name: YLR467W
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 5" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-5" EXACT []

[Term]
id: sgd:S000004460
name: YML001W
def: "Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance\, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AST4" EXACT []
synonym: "Rab family GTPase YPT7" EXACT []
synonym: "VAM4" EXACT []
synonym: "YPT7" EXACT []

[Term]
id: sgd:S000004461
name: YML002W
def: "Putative protein of unknown function; expression induced by heat and by calcium shortage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004462
name: YML003W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004463
name: YML004C
def: "Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal \(a by-product of glycolysis\) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLO1" EXACT []
synonym: "lactoylglutathione lyase GLO1" EXACT []

[Term]
id: sgd:S000004464
name: YML005W
def: "S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM12" EXACT []
synonym: "TYW2" EXACT []

[Term]
id: sgd:S000004465
name: YML006C
def: "CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIS4" EXACT []

[Term]
id: sgd:S000004466
name: YML007W
def: "Basic leucine zipper \(bZIP\) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog\, CAD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding transcription factor YAP1" EXACT []
synonym: "PAR1" EXACT []
synonym: "SNQ3" EXACT []
synonym: "YAP1" EXACT []

[Term]
id: sgd:S000004467
name: YML008C
def: "Delta\(24\)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles\, the plasma membrane-associated endoplasmic reticulum\, and the mitochondrial outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG6" EXACT []
synonym: "ISE1" EXACT []
synonym: "LIS1" EXACT []
synonym: "SED6" EXACT []
synonym: "VID1" EXACT []
synonym: "sterol 24-C-methyltransferase" EXACT []

[Term]
id: sgd:S000004468
name: YML009C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL39" EXACT []
synonym: "YmL39" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL39" EXACT []

[Term]
id: sgd:S000004469
name: YML009C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORFs SPT5/YML010W and YML009W-B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML010C-B" EXACT []
synonym: "YML010W-B" EXACT []

[Term]
id: sgd:S000004470
name: YML010W
def: "Component of the universally conserved Spt4/5 complex \(DSIF complex\); the complex has multiple roles in concert with RNA polymerases I and II\, including regulation of transcription elongation\, RNA processing\, quality control\, and transcription-coupled DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPT5" EXACT []
synonym: "transcription elongation factor SPT5" EXACT []

[Term]
id: sgd:S000004471
name: YML009W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML010W-A" EXACT []

[Term]
id: sgd:S000004472
name: YML011C
def: "Protein involved in nucleotide excision repair; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD33" EXACT []

[Term]
id: sgd:S000004473
name: YML012W
def: "Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1\, Erp2p\, and Emp24\," []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV25" EXACT []

[Term]
id: sgd:S000004474
name: YML012C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML013C-A" EXACT []

[Term]
id: sgd:S000004475
name: YML013W
def: "Bridging factor involved in ER-associated protein degradation \(ERAD\); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX \(ubiquitin regulatory X\) domain and a ubiquitin-associated \(UBA\) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEL1" EXACT []
synonym: "UBX2" EXACT []

[Term]
id: sgd:S000004476
name: YML014W
def: "tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2\, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity\, including amino acid misincorporation and -1 frameshifting\, and also confers resistance to zymocin; null mutant displays activation of stress responses" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTI1" EXACT []
synonym: "TRM9" EXACT []

[Term]
id: sgd:S000004477
name: YML015C
def: "TFIID subunit \(40 kDa\); involved in RNA polymerase II transcription initiation\, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF11" EXACT []
synonym: "TAF40" EXACT []
synonym: "TafII40" EXACT []

[Term]
id: sgd:S000004478
name: YML016C
def: "Serine/threonine protein phosphatase Z\, isoform of Ppz2p; involved in regulation of potassium transport\, which affects osmotic stability\, cell cycle progression\, and halotolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPZ1" EXACT []

[Term]
id: sgd:S000004479
name: YML017W
def: "Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 \(DNA polymerase alpha\); possible role in mitochondrial mRNA splicing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS15" EXACT []
synonym: "PSP2" EXACT []

[Term]
id: sgd:S000004480
name: YML018C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog\, THI74\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004481
name: YML019W
def: "Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OST6" EXACT []

[Term]
id: sgd:S000004482
name: YML020W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004483
name: YML021C
def: "Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated\, expressed in late G1; localizes to mitochondria and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UNG1" EXACT []

[Term]
id: sgd:S000004484
name: YML022W
def: "Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog\, APT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APT1" EXACT []
synonym: "adenine phosphoribosyltransferase APT1" EXACT []

[Term]
id: sgd:S000004485
name: YML023C
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSE5" EXACT []

[Term]
id: sgd:S000004486
name: YML024W
def: "Ribosomal protein 51 \(rp51\) of the small \(40s\) subunit; homologous to mammalian ribosomal protein S17\, no bacterial homolog; RPS17A has a paralog\, RPS17B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RP51A" EXACT []
synonym: "RPL51A" EXACT []
synonym: "RPS17A" EXACT []
synonym: "S17A" EXACT []
synonym: "S17e" EXACT []
synonym: "ribosomal 40S subunit protein S17A" EXACT []
synonym: "rp51A" EXACT []

[Term]
id: sgd:S000004487
name: YML025C
def: "Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability\, unlike most other mitoribosomal proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML6" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL6" EXACT []

[Term]
id: sgd:S000004488
name: YML026C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog\, RPS18A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS18B" EXACT []
synonym: "S13" EXACT []
synonym: "S18B" EXACT []
synonym: "ribosomal 40S subunit protein S18B" EXACT []

[Term]
id: sgd:S000004489
name: YML027W
def: "Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes \(ECBs\) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog\, YHP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOX1" EXACT []

[Term]
id: sgd:S000004490
name: YML028W
def: "Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; protein abundance increases\, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog\, TSA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPX1" EXACT []
synonym: "TSA1" EXACT []
synonym: "ZRG14" EXACT []
synonym: "cTPxI" EXACT []
synonym: "thioredoxin peroxidase TSA1" EXACT []

[Term]
id: sgd:S000004491
name: YML029W
def: "Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation \(ERAD\); interacts with the U1 snRNP-specific protein\, Snp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "USA1" EXACT []

[Term]
id: sgd:S000004492
name: YML030W
def: "Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex\, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p\, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM31" EXACT []
synonym: "RCF1" EXACT []

[Term]
id: sgd:S000004493
name: YML031W
def: "Subunit of the transmembrane ring of the nuclear pore complex \(NPC\); contributes to nucleocytoplasmic transport\, NPC biogenesis and spindle pole body duplication; homologous to human NDC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDC1" EXACT []

[Term]
id: sgd:S000004494
name: YML032C
def: "Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD52" EXACT []
synonym: "recombinase RAD52" EXACT []

[Term]
id: sgd:S000004497
name: YML034W
def: "Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX \(transcription export\) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog\, HEH2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEH1" EXACT []
synonym: "SRC1" EXACT []
synonym: "YML033W" EXACT []

[Term]
id: sgd:S000004498
name: YML035C
def: "AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine \(adenine\, guanine\, and inosine\) nucleotide pools" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMD1" EXACT []
synonym: "AMD3" EXACT []
synonym: "AMP deaminase" EXACT []

[Term]
id: sgd:S000004499
name: YML034C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF SRC1/YML034W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML035C-A" EXACT []

[Term]
id: sgd:S000004500
name: YML036W
def: "Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p\, Kae1p\, Pcc1p\, and Gon7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CGI121" EXACT []

[Term]
id: sgd:S000004501
name: YML037C
def: "Putative protein of unknown function; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004502
name: YML038C
def: "Putative nucleotide sugar transporter; has similarity to Vrg4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMD8" EXACT []

[Term]
id: sgd:S000004505
name: YML041C
def: "Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ \(Htz1p\) for chromatin-bound histone H2A; required for vacuolar protein sorting" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWC6" EXACT []
synonym: "VPS71" EXACT []

[Term]
id: sgd:S000004506
name: YML042W
def: "Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAT2" EXACT []
synonym: "YCAT" EXACT []
synonym: "carnitine O-acetyltransferase CAT2" EXACT []

[Term]
id: sgd:S000004507
name: YML043C
def: "Component of the core factor \(CF\) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p\, Rrn7p\, and Rrn11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN11" EXACT []

[Term]
id: sgd:S000004509
name: YML046W
def: "U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP39" EXACT []

[Term]
id: sgd:S000004510
name: YML047C
def: "Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system \(HACS\) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog\, KCH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KCH2" EXACT []
synonym: "PRM6" EXACT []
synonym: "pheromone-regulated K(+) transporter PRM6" EXACT []

[Term]
id: sgd:S000004511
name: YML048W
def: "Endoplasmic reticulum \(ER\) localized integral membrane protein; may promote secretion of certain hexose transporters\, including Gal2p; involved in glucose-dependent repression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM6" EXACT []
synonym: "GSF2" EXACT []

[Term]
id: sgd:S000004512
name: YML047W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF PRM6/YML047C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML048W-A" EXACT []

[Term]
id: sgd:S000004513
name: YML049C
def: "Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSE1" EXACT []

[Term]
id: sgd:S000004514
name: YML050W
def: "Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM32" EXACT []

[Term]
id: sgd:S000004515
name: YML051W
def: "Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL80" EXACT []
synonym: "transcription regulator GAL80" EXACT []

[Term]
id: sgd:S000004516
name: YML052W
def: "Plasma membrane protein\, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins\, Pil1p and Lsp1p\, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations \(MCC patches\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUR7" EXACT []

[Term]
id: sgd:S000004517
name: YML053C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004518
name: YML054C
def: "Cytochrome b2 \(L-lactate cytochrome-c oxidoreductase\); component of the mitochondrial intermembrane space\, required for lactate utilization; expression is repressed by glucose and anaerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYB2" EXACT []
synonym: "FCB2" EXACT []

[Term]
id: sgd:S000004519
name: YML055W
def: "Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; other members of the complex are Spc1p\, Spc1p\, and Sec11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC2" EXACT []
synonym: "SPY1" EXACT []

[Term]
id: sgd:S000004520
name: YML056C
def: "Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae\, constitutively expressed; IMD4 has a paralog\, IMD3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMD4" EXACT []
synonym: "IMP dehydrogenase IMD4" EXACT []

[Term]
id: sgd:S000004521
name: YML057W
def: "Calcineurin A; one isoform \(the other is Cna1p\) of the catalytic subunit of calcineurin\, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p \(a stress-response transcription factor\)\, the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog\, CNA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMP2" EXACT []
synonym: "CNA2" EXACT []
synonym: "calcineurin catalytic subunit A" EXACT []

[Term]
id: sgd:S000004522
name: YML057C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML058C-A" EXACT []

[Term]
id: sgd:S000004523
name: YML058W
def: "Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog\, DIF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SML1" EXACT []
synonym: "ribonucleotide reductase inhibiting protein SML1" EXACT []

[Term]
id: sgd:S000004524
name: YML059C
def: "Serine esterase; homolog of human neuropathy target esterase \(NTE\); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization\, affecting transcriptional regulation of phospholipid biosynthesis genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTE1" EXACT []

[Term]
id: sgd:S000004525
name: YML060W
def: "Nuclear and mitochondrial glycosylase/lyase; specifically excises 7\,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA\, repairs oxidative damage to mitochondrial DNA\, contributes to UVA resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "8-oxoguanine glycosylase OGG1" EXACT []
synonym: "OGG1" EXACT []

[Term]
id: sgd:S000004526
name: YML061C
def: "DNA helicase\, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; translation from different start sites produces mitochondrial and nuclear forms; nuclear form is a catalytic inhibitor of telomerase; mitochondrial form involved in DNA repair and recombination; mutations affect Zn\, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA helicase PIF1" EXACT []
synonym: "PIF1" EXACT []
synonym: "TST1" EXACT []

[Term]
id: sgd:S000004527
name: YML062C
def: "Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p\, Mft1p\, Rlr1p\, and Thp2p\, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFT1" EXACT []
synonym: "MFT52" EXACT []

[Term]
id: sgd:S000004528
name: YML063W
def: "Ribosomal protein 10 \(rp10\) of the small \(40S\) subunit; homologous to mammalian ribosomal protein S3A\, no bacterial homolog; RPS1B has a paralog\, RPS1A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLC2" EXACT []
synonym: "RP10B" EXACT []
synonym: "RPS1B" EXACT []
synonym: "S1B" EXACT []
synonym: "S1e" EXACT []
synonym: "ribosomal 40S subunit protein S1B" EXACT []
synonym: "rp10B" EXACT []

[Term]
id: sgd:S000004529
name: YML064C
def: "GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Ras family GTPase TEM1" EXACT []
synonym: "TEM1" EXACT []

[Term]
id: sgd:S000004530
name: YML065W
def: "Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog\, SIR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC1" EXACT []
synonym: "origin recognition complex subunit 1" EXACT []

[Term]
id: sgd:S000004531
name: YML066C
def: "Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMA2" EXACT []

[Term]
id: sgd:S000004532
name: YML067C
def: "Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 \(PTX1\) protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV41" EXACT []

[Term]
id: sgd:S000004533
name: YML068W
def: "Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 \(Sup45p\) and eRF3 \(Sup35p\) in vitro\, contains a zinc finger domain characteristic of the TRIAD class of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ITT1" EXACT []

[Term]
id: sgd:S000004534
name: YML069W
def: "Subunit of the heterodimeric FACT complex \(Spt16p-Pob3p\); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp\, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FACT complex subunit POB3" EXACT []
synonym: "POB3" EXACT []

[Term]
id: sgd:S000004535
name: YML070W
def: "Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone \(DHA\); involved in stress adaptation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAK1" EXACT []

[Term]
id: sgd:S000004536
name: YML071C
def: "Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COG8" EXACT []
synonym: "DOR1" EXACT []

[Term]
id: sgd:S000004537
name: YML072C
def: "Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to the plasma membrane \(PM\) and regulate PM phosphatidylinositol-4-phosphate \(PI4P\) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p\, Tcb2p and Tcb3p interact" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCB3" EXACT []

[Term]
id: sgd:S000004538
name: YML073C
def: "Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6\, no bacterial homolog; RPL6A has a paralog\, RPL6B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L17A" EXACT []
synonym: "L6A" EXACT []
synonym: "L6e" EXACT []
synonym: "RPL6A" EXACT []
synonym: "YL16" EXACT []
synonym: "YL16A" EXACT []
synonym: "ribosomal 60S subunit protein L6A" EXACT []
synonym: "rp18" EXACT []

[Term]
id: sgd:S000004539
name: YML074C
def: "Nucleolar peptidyl-prolyl cis-trans isomerase \(PPIase\); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II \(Cka1p-Cka2p-Ckb1p-Ckb2p\) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA\, and repressor activity is dependent on PPIase activity; FPR3 has a paralog\, FPR4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FPR3" EXACT []
synonym: "NPI46" EXACT []
synonym: "peptidylprolyl isomerase FPR3" EXACT []

[Term]
id: sgd:S000004540
name: YML075C
def: "HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate\, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress; HMG1 has a paralog\, HMG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMG1" EXACT []
synonym: "hydroxymethylglutaryl-CoA reductase (NADPH) HMG1" EXACT []

[Term]
id: sgd:S000004541
name: YML076C
def: "Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34\, encoding an acid transporter and a putative ammonia transporter\, respectively" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WAR1" EXACT []

[Term]
id: sgd:S000004542
name: YML077W
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BET5" EXACT []

[Term]
id: sgd:S000004543
name: YML078W
def: "Mitochondrial peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR3" EXACT []
synonym: "CYP3" EXACT []
synonym: "peptidylprolyl isomerase CPR3" EXACT []

[Term]
id: sgd:S000004544
name: YML079W
def: "Non-essential protein of unknown function; has structural resemblance to plant storage and ligand binding proteins \(canavalin\, glycinin\, auxin binding protein\) and to some enzymes \(epimerase\, germin\); localizes to the nucleus and cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004545
name: YML080W
def: "Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p\, Dus3p\, and Dus4p; modifies pre-tRNA\(Phe\) at U17" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUS1" EXACT []

[Term]
id: sgd:S000004546
name: YML081W
def: "Transcription factor that regulates acetate production; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog\, RSF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAF1" EXACT []
synonym: "TDA9" EXACT []

[Term]
id: sgd:S000004547
name: YML082W
def: "Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog\, STR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative cystathionine gamma-synthase" EXACT []

[Term]
id: sgd:S000004548
name: YML083C
def: "Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004549
name: YML084W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004550
name: YML085C
def: "Alpha-tubulin; associates with beta-tubulin \(Tub2p\) to form tubulin dimer\, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog\, TUB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUB1" EXACT []
synonym: "alpha-tubulin TUB1" EXACT []

[Term]
id: sgd:S000004551
name: YML086C
def: "D-Arabinono-1\,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1\,4-lactone\, which is protective against oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4-lactone oxidase" EXACT []
synonym: "ALO1" EXACT []
synonym: "D-arabinono-1" EXACT []

[Term]
id: sgd:S000004552
name: YML087C
def: "Putative protein of unknown function\, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog\, PGA3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM33" EXACT []

[Term]
id: sgd:S000004553
name: YML088W
def: "F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor \(SCF\) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease\, allowing its ubiquitylation by SCF and subsequent degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCF ubiquitin ligase complex subunit UFO1" EXACT []
synonym: "UFO1" EXACT []

[Term]
id: sgd:S000004554
name: YML089C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; expression induced by calcium shortage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004555
name: YML090W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable \(respiratory\) carbon source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004556
name: YML091C
def: "Protein subunit of mitochondrial RNase P; has roles in nuclear transcription\, cytoplasmic and mitochondrial RNA processing\, and mitochondrial translation; distributed to mitochondria\, cytoplasmic processing bodies\, and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPM2" EXACT []

[Term]
id: sgd:S000004557
name: YML092C
def: "Alpha 2 subunit of the 20S proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE8" EXACT []
synonym: "proteasome core particle subunit alpha 2" EXACT []

[Term]
id: sgd:S000004558
name: YML093W
def: "Subunit of U3-containing Small Subunit \(SSU\) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP14" EXACT []

[Term]
id: sgd:S000004559
name: YML094W
def: "Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM5" EXACT []
synonym: "PFD5" EXACT []

[Term]
id: sgd:S000004560
name: YML095C
def: "Single-stranded DNA endonuclease \(with Rad1p\); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 \(NEF1\); homolog of human ERCC1 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD10" EXACT []

[Term]
id: sgd:S000004561
name: YML094C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML095C-A" EXACT []

[Term]
id: sgd:S000004562
name: YML096W
def: "Putative protein with similarity to asparagine synthetases; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative asparagine synthase" EXACT []

[Term]
id: sgd:S000004563
name: YML097C
def: "Guanine nucleotide exchange factor \(GEF\); involved in vesicle-mediated vacuolar transport\, including Golgi-endosome trafficking and sorting through the multivesicular body \(MVB\); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members \(Vps21p/Ypt52p/Ypt53p\); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a VPS9 domain; binds ubiquitin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPL31" EXACT []
synonym: "VPS9" EXACT []
synonym: "VPT9" EXACT []
synonym: "guanine nucleotide exchange factor VPS9" EXACT []

[Term]
id: sgd:S000004564
name: YML098W
def: "TFIID subunit \(19 kDa\); involved in RNA polymerase II transcription initiation\, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN81" EXACT []
synonym: "TAF13" EXACT []
synonym: "TAF19" EXACT []
synonym: "TafII19" EXACT []

[Term]
id: sgd:S000004565
name: YML099C
def: "Zinc finger transcription factor involved in arginine-responsive genes; Zn\(2\)-Cys\(6\) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG81" EXACT []
synonym: "ARGR2" EXACT []
synonym: "ARGRII" EXACT []

[Term]
id: sgd:S000004566
name: YML100W
def: "Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog\, TPS3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSL1" EXACT []

[Term]
id: sgd:S000004567
name: YML099W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML100W-A" EXACT []

[Term]
id: sgd:S000004568
name: YML101C
def: "Protein of unknown function; has a CUE domain that binds ubiquitin\, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog\, CUE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUE4" EXACT []

[Term]
id: sgd:S000004569
name: YML101C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML102C-A" EXACT []

[Term]
id: sgd:S000004570
name: YML102W
def: "Subunit of chromatin assembly factor I \(CAF-1\)\, with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres\, mating type loci\, and rDNA; maintenance of kinetochore structure\, deactivation of the DNA damage checkpoint after DNA repair\, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAC2" EXACT []

[Term]
id: sgd:S000004571
name: YML103C
def: "Subunit of the inner ring of the nuclear pore complex \(NPC\); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUP188" EXACT []

[Term]
id: sgd:S000004572
name: YML104C
def: "Intermediate filament protein; required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology \(PX\) domain and specifically binds phosphatidylinositol 3-phosphate \(PtdIns-3-P\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM1" EXACT []

[Term]
id: sgd:S000004573
name: YML105C
def: "Subunit of the signal recognition particle \(SRP\); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC65" EXACT []

[Term]
id: sgd:S000004574
name: YML106W
def: "Major orotate phosphoribosyltransferase \(OPRTase\) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines\, converting orotate into orotidine-5'-phosphate; URA5 has a paralog\, URA10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PYR5" EXACT []
synonym: "URA5" EXACT []
synonym: "orotate phosphoribosyltransferase URA5" EXACT []

[Term]
id: sgd:S000004575
name: YML107C
def: "Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PML39" EXACT []

[Term]
id: sgd:S000004576
name: YML108W
def: "Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004577
name: YML109W
def: "Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog\, ZDS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CES4" EXACT []
synonym: "ZDS2" EXACT []

[Term]
id: sgd:S000004578
name: YML110C
def: "2-hexaprenyl-6-methoxy-1\,4-benzoquinone methyltransferase; involved in ubiquinone \(Coenzyme Q\) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-hexaprenyl-6-methoxy-1" EXACT []
synonym: "4-benzoquinone methyltransferase" EXACT []
synonym: "COQ5" EXACT []
synonym: "DBI56" EXACT []

[Term]
id: sgd:S000004579
name: YML111W
def: "Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting\, functions in heat shock element mediated gene expression\, essential for growth in stress conditions; BUL2 has a paralog\, BUL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUL2" EXACT []
synonym: "ubiquitin-ubiquitin ligase BUL2" EXACT []

[Term]
id: sgd:S000004580
name: YML112W
def: "Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing\, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTK3" EXACT []

[Term]
id: sgd:S000004581
name: YML113W
def: "DNA binding protein that recognizes oligo\(dA\).oligo\(dT\) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAT1" EXACT []

[Term]
id: sgd:S000004582
name: YML114C
def: "TFIID subunit \(65 kDa\); involved in RNA polymerase II transcription initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF65" EXACT []
synonym: "TAF8" EXACT []
synonym: "TafII65" EXACT []

[Term]
id: sgd:S000004583
name: YML115C
def: "Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB13" EXACT []
synonym: "VAN1" EXACT []
synonym: "VRG7" EXACT []
synonym: "VRG8" EXACT []

[Term]
id: sgd:S000004584
name: YML116W
def: "Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog\, YMR279C\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATR1" EXACT []
synonym: "SNQ1" EXACT []

[Term]
id: sgd:S000004585
name: YML117W
def: "Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAB6" EXACT []

[Term]
id: sgd:S000004586
name: YML116W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML117W-A" EXACT []

[Term]
id: sgd:S000004587
name: YML118W
def: "3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog\, NGL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NGL3" EXACT []

[Term]
id: sgd:S000004588
name: YML119W
def: "Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004589
name: YML120C
def: "NADH\:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons\, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress\, Ndip is activated in the mitochondria by N-terminal cleavage\, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NADH-ubiquinone reductase (H(+)-translocating) NDI1" EXACT []
synonym: "NDI1" EXACT []

[Term]
id: sgd:S000004590
name: YML121W
def: "Cytoplasmic GTPase; forms a heterodimer with Gtr2p to stimulate TORC1 in response to amino acids; component of GSE complex\, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTR1" EXACT []
synonym: "Rag GTPase GTR1" EXACT []

[Term]
id: sgd:S000004591
name: YML122C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004592
name: YML123C
def: "High-affinity inorganic phosphate \(Pi\) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO84" EXACT []
synonym: "phoT" EXACT []
synonym: "phosphate transporter PHO84" EXACT []

[Term]
id: sgd:S000004593
name: YML124C
def: "Alpha-tubulin; associates with beta-tubulin \(Tub2p\) to form tubulin dimer\, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog\, TUB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUB3" EXACT []
synonym: "alpha-tubulin TUB3" EXACT []

[Term]
id: sgd:S000004594
name: YML125C
def: "Putative cytochrome b5 reductase\, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p\, proposed to be involved in protein trafficking; PGA3 has a paralog\, AIM33\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NQR1" EXACT []
synonym: "PGA3" EXACT []

[Term]
id: sgd:S000004595
name: YML126C
def: "3-hydroxy-3-methylglutaryl-CoA \(HMG-CoA\) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG13" EXACT []
synonym: "HMGS" EXACT []
synonym: "hydroxymethylglutaryl-CoA synthase" EXACT []

[Term]
id: sgd:S000004596
name: YML127W
def: "Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin \(TOR\) pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSC9" EXACT []

[Term]
id: sgd:S000004597
name: YML128C
def: "Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic\, non-tagged protein is detected in highly purified mitochondria and is phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSC1" EXACT []

[Term]
id: sgd:S000004598
name: YML129C
def: "Mitochondrial cytochrome c oxidase \(complex IV\) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX14" EXACT []

[Term]
id: sgd:S000004599
name: YML130C
def: "Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERO1" EXACT []

[Term]
id: sgd:S000004600
name: YML131W
def: "Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock\, DNA damaging agents\, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004601
name: YML132W
def: "Protein involved in salt resistance; interacts with sodium\:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS3" EXACT []

[Term]
id: sgd:S000004602
name: YML133C
def: "Putative Y' element ATP-dependent helicase; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000004603
name: YMR001C
def: "Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rholp guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC5" EXACT []
synonym: "MSD2" EXACT []
synonym: "PKX2" EXACT []
synonym: "polo kinase CDC5" EXACT []

[Term]
id: sgd:S000004604
name: YMR002W
def: "Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIC17" EXACT []
synonym: "MIX17" EXACT []

[Term]
id: sgd:S000004605
name: YMR003W
def: "Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM34" EXACT []

[Term]
id: sgd:S000004606
name: YMR004W
def: "Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with \"foot domain\" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MVP1" EXACT []

[Term]
id: sgd:S000004607
name: YMR005W
def: "TFIID subunit \(48 kDa\); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPT1" EXACT []
synonym: "TAF4" EXACT []
synonym: "TAF48" EXACT []
synonym: "TSG2" EXACT []
synonym: "TafII48" EXACT []

[Term]
id: sgd:S000004608
name: YMR006C
def: "Phospholipase B \(lysophospholipase\) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLB2" EXACT []

[Term]
id: sgd:S000004609
name: YMR007W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004610
name: YMR008C
def: "Phospholipase B \(lysophospholipase\) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog\, PLB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLB1" EXACT []

[Term]
id: sgd:S000004611
name: YMR009W
def: "Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III \(Rnt1p\) cleavage; ADI1 mRNA is induced in heat shock conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADI1" EXACT []
synonym: "acireductone dioxygenase (Ni2+-requiring)" EXACT []

[Term]
id: sgd:S000004612
name: YMR010W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004613
name: YMR011W
def: "High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT2" EXACT []
synonym: "hexose transporter HXT2" EXACT []

[Term]
id: sgd:S000004614
name: YMR012W
def: "Subunit of the eukaryotic translation initiation factor 3 \(eIF3\); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLU1" EXACT []
synonym: "TIF31" EXACT []

[Term]
id: sgd:S000004615
name: YMR013C
def: "Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate \(Dol-P\) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC59" EXACT []

[Term]
id: sgd:S000004616
name: YMR014W
def: "Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition\, and affects budding pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD22" EXACT []

[Term]
id: sgd:S000004617
name: YMR015C
def: "C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22\(23\) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C-22 sterol desaturase" EXACT []
synonym: "CYP61" EXACT []
synonym: "ERG5" EXACT []

[Term]
id: sgd:S000004618
name: YMR016C
def: "Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP \(cAMP\)-dependent protein kinase \(PKA\) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog\, PHD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOK2" EXACT []

[Term]
id: sgd:S000004619
name: YMR017W
def: "Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBI9" EXACT []
synonym: "SPO20" EXACT []

[Term]
id: sgd:S000004620
name: YMR018W
def: "Putative protein of unknown function with similarity to human PEX5Rp; transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene; PEX5Rp is also known as peroxin protein 5 related protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004621
name: YMR019W
def: "Putative transcription factor; contains a Zn\(II\)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB4" EXACT []

[Term]
id: sgd:S000004622
name: YMR020W
def: "Polyamine oxidase; converts spermine to spermidine\, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMS1" EXACT []
synonym: "polyamine oxidase" EXACT []

[Term]
id: sgd:S000004623
name: YMR021C
def: "Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUA1" EXACT []
synonym: "MAC1" EXACT []

[Term]
id: sgd:S000004624
name: YMR022W
def: "Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DER2" EXACT []
synonym: "E2 ubiquitin-conjugating protein UBC7" EXACT []
synonym: "QRI8" EXACT []
synonym: "UBC7" EXACT []

[Term]
id: sgd:S000004625
name: YMR023C
def: "Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS1" EXACT []
synonym: "PET53" EXACT []

[Term]
id: sgd:S000004626
name: YMR024W
def: "Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome\, and in tissue-specific respiratory chain deficiency\, manifesting as either Complex I+Complex IV or Complex IV deficiency\, depending on a cell type" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL3" EXACT []
synonym: "YmL3" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL3" EXACT []

[Term]
id: sgd:S000004627
name: YMR025W
def: "Subunit of the Cop9 signalosome; which is required for deneddylation\, or removal of the ubiquitin-like protein Rub1p from Cdc53p \(cullin\); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSI1" EXACT []

[Term]
id: sgd:S000004628
name: YMR026C
def: "C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS11" EXACT []
synonym: "PEX12" EXACT []
synonym: "ubiquitin-protein ligase peroxin 12" EXACT []

[Term]
id: sgd:S000004629
name: YMR027W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004630
name: YMR028W
def: "Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAP42" EXACT []

[Term]
id: sgd:S000004631
name: YMR029C
def: "Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p\, Far7p\, Far9p\, Far10p\, and Far11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR8" EXACT []

[Term]
id: sgd:S000004632
name: YMR030W
def: "Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSF1" EXACT []

[Term]
id: sgd:S000004633
name: YMR031C
def: "Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic\, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog\, YKL050C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EIS1" EXACT []

[Term]
id: sgd:S000004634
name: YMR031W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004635
name: YMR032W
def: "SH3 domain-containing protein required for cytokinesis; localized to bud neck; phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins\, Bni1p and Bnr1p\, and with Cyk3p\, Vrp1p\, and Bni5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYK2" EXACT []
synonym: "HOF1" EXACT []
synonym: "formin-binding protein HOF1" EXACT []

[Term]
id: sgd:S000004636
name: YMR033W
def: "Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP9" EXACT []
synonym: "RSC12" EXACT []
synonym: "SWP59" EXACT []

[Term]
id: sgd:S000004637
name: YMR034C
def: "Putative transporter; member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004638
name: YMR035W
def: "Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits \(Imp1p and Imp2p that differ in substrate specificity\)\, and Som1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP2" EXACT []

[Term]
id: sgd:S000004639
name: YMR036C
def: "Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIH1" EXACT []
synonym: "putative tyrosine protein phosphatase MIH1" EXACT []

[Term]
id: sgd:S000004640
name: YMR037C
def: "Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSN2" EXACT []
synonym: "stress-responsive transcriptional activator MSN2" EXACT []

[Term]
id: sgd:S000004641
name: YMR038C
def: "Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCS" EXACT []
synonym: "CCS1" EXACT []
synonym: "LYS7" EXACT []

[Term]
id: sgd:S000004642
name: YMR039C
def: "Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining \(NHEJ\) of ds breaks in plasmid DNA\, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUB1" EXACT []
synonym: "TSP1" EXACT []

[Term]
id: sgd:S000004643
name: YMR040W
def: "Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog\, YET1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YET2" EXACT []

[Term]
id: sgd:S000004644
name: YMR041C
def: "NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1\,4-lactone; similar to plant L-galactose dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARA2" EXACT []
synonym: "D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2" EXACT []

[Term]
id: sgd:S000004645
name: YMR042W
def: "Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG80" EXACT []
synonym: "ARGR1" EXACT []
synonym: "ARGRI" EXACT []

[Term]
id: sgd:S000004646
name: YMR043W
def: "Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUN80" EXACT []
synonym: "MCM1" EXACT []
synonym: "transcription factor MCM1" EXACT []

[Term]
id: sgd:S000004647
name: YMR044W
def: "Member of a complex \(Isw1b\) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IOC4" EXACT []

[Term]
id: sgd:S000004650
name: YMR047C
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex \(NPC\) permeability barrier; forms a stable association with Nup82p\, Gle2p and two other FG-nucleoporins \(Nsp1p and Nup159p\); NUP116 has a paralog\, NUP100\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP116" EXACT []
synonym: "NSP116" EXACT []
synonym: "NUP116" EXACT []

[Term]
id: sgd:S000004651
name: YMR048W
def: "Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSM3" EXACT []

[Term]
id: sgd:S000004652
name: YMR049C
def: "Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERB1" EXACT []

[Term]
id: sgd:S000004655
name: YMR052C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004656
name: YMR052W
def: "Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone\, in a Far1p-independent pathway; interacts with Far7p\, Far8p\, Far9p\, Far10p\, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR3" EXACT []

[Term]
id: sgd:S000004657
name: YMR053C
def: "Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog\, STB6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB2" EXACT []

[Term]
id: sgd:S000004658
name: YMR054W
def: "Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms \(Stv1p and Vph1p\); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V0 sector ATPase subunit a" EXACT []
synonym: "STV1" EXACT []

[Term]
id: sgd:S000004659
name: YMR055C
def: "Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies\, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUB2" EXACT []
synonym: "PAC7" EXACT []

[Term]
id: sgd:S000004660
name: YMR056C
def: "Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAC1" EXACT []
synonym: "ADP/ATP carrier protein AAC1" EXACT []

[Term]
id: sgd:S000004661
name: YMR057C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004662
name: YMR058W
def: "Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous \(Fe2+\) to ferric iron \(Fe3+\) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity\, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FET3" EXACT []
synonym: "ferroxidase FET3" EXACT []

[Term]
id: sgd:S000004663
name: YMR059W
def: "Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p\, Sen15p\, Sen34p\, and Sen54p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEN15" EXACT []

[Term]
id: sgd:S000004664
name: YMR060C
def: "Component of the Sorting and Assembly Machinery \(SAM\) complex; the SAM \(or TOB\) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS37" EXACT []
synonym: "PET3027" EXACT []
synonym: "SAM complex subunit SAM37" EXACT []
synonym: "SAM37" EXACT []
synonym: "TOM37" EXACT []

[Term]
id: sgd:S000004665
name: YMR061W
def: "Component of the cleavage and polyadenylation factor I \(CF I\); CF 1\, composed of the CF 1A complex \(Rna14p\, Rna15p\, Clp1p\, Pcf11p\) and Hrp1\, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on \(GLRO\) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA14" EXACT []

[Term]
id: sgd:S000004666
name: YMR062C
def: "Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity\, regenerates acetylglutamate while forming ornithine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG7" EXACT []
synonym: "ECM40" EXACT []
synonym: "glutamate N-acetyltransferase" EXACT []

[Term]
id: sgd:S000004667
name: YMR063W
def: "Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM9" EXACT []

[Term]
id: sgd:S000004668
name: YMR064W
def: "Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AEP1" EXACT []
synonym: "NCA1" EXACT []

[Term]
id: sgd:S000004669
name: YMR065W
def: "Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen\, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIG3" EXACT []
synonym: "KAR5" EXACT []

[Term]
id: sgd:S000004670
name: YMR066W
def: "Mitochondrial protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOV1" EXACT []

[Term]
id: sgd:S000004671
name: YMR067C
def: "UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD \(ER-associated degradation\) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUI1" EXACT []
synonym: "UBX4" EXACT []

[Term]
id: sgd:S000004672
name: YMR068W
def: "Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVO2" EXACT []

[Term]
id: sgd:S000004673
name: YMR069W
def: "N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAA40" EXACT []
synonym: "NAT4" EXACT []

[Term]
id: sgd:S000004674
name: YMR070W
def: "Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p\, repression of several DAN/TIR genes during aerobic growth and ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; relocalizes to the cytosol in response to hypoxia; can form \[MOT3+\] prion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOT3" EXACT []
synonym: "ROX7" EXACT []
synonym: "[MOT3+]" EXACT []
synonym: "[MOT3]" EXACT []

[Term]
id: sgd:S000004675
name: YMR071C
def: "Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes\, based on co-purification experiments; may have a role in intracellular sterol transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TVP18" EXACT []

[Term]
id: sgd:S000004676
name: YMR072W
def: "Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination\, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog\, IXR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABF2" EXACT []

[Term]
id: sgd:S000004677
name: YMR073C
def: "Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC21" EXACT []

[Term]
id: sgd:S000004678
name: YMR074C
def: "Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004679
name: YMR075C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004680
name: YMR075W
def: "Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCO1" EXACT []

[Term]
id: sgd:S000004681
name: YMR076C
def: "Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; also required during meiosis; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDS5" EXACT []

[Term]
id: sgd:S000004682
name: YMR077C
def: "Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHM6" EXACT []
synonym: "ESCRT-III subunit protein VPS20" EXACT []
synonym: "VPL10" EXACT []
synonym: "VPS20" EXACT []
synonym: "VPT20" EXACT []

[Term]
id: sgd:S000004683
name: YMR078C
def: "Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL12" EXACT []
synonym: "CTF18" EXACT []

[Term]
id: sgd:S000004684
name: YMR079W
def: "Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns\, PtdCho\, and ceramide metabolism\, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog\, YKL091C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIT1" EXACT []
synonym: "SEC14" EXACT []
synonym: "phosphatidylinositol/phosphatidylcholine transfer protein SEC14" EXACT []

[Term]
id: sgd:S000004685
name: YMR080C
def: "ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase NAM7" EXACT []
synonym: "IFS2" EXACT []
synonym: "MOF4" EXACT []
synonym: "NAM7" EXACT []
synonym: "SUP113" EXACT []
synonym: "UPF1" EXACT []

[Term]
id: sgd:S000004686
name: YMR081C
def: "Serine-rich\, hydrophilic protein; overexpression suppresses growth defects of hap2\, hap3\, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog\, MBR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISF1" EXACT []
synonym: "MBR3" EXACT []

[Term]
id: sgd:S000004687
name: YMR082C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004688
name: YMR083W
def: "Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH3" EXACT []
synonym: "alcohol dehydrogenase ADH3" EXACT []

[Term]
id: sgd:S000004689
name: YMR084W
def: "Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains\, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004690
name: YMR085W
def: "Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains\, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004691
name: YMR086C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004692
name: YMR086W
def: "Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation\, controls eisosome length and shape; diffusely distributed\, forms heterogeneous patches at plasma membrane in small buds\, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p\, important for generating eisosomes; SEG1 has a paralog\, SEG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEG1" EXACT []

[Term]
id: sgd:S000004693
name: YMR087W
def: "Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004694
name: YMR088C
def: "Permease of basic amino acids in the vacuolar membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VBA1" EXACT []

[Term]
id: sgd:S000004695
name: YMR089C
def: "Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCA1" EXACT []
synonym: "YTA12" EXACT []
synonym: "m-AAA protease subunit YTA12" EXACT []

[Term]
id: sgd:S000004696
name: YMR090W
def: "Putative protein of unknown function; similar to DTDP-glucose 4\,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004697
name: YMR091C
def: "Component of the RSC chromatin remodeling complex; interacts with Rsc3p\, Rsc30p\, Ldb7p\, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPL6" EXACT []
synonym: "RSC7" EXACT []

[Term]
id: sgd:S000004698
name: YMR092C
def: "Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIP1" EXACT []

[Term]
id: sgd:S000004699
name: YMR093W
def: "Nucleolar protein; component of the small subunit \(SSU\) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP15" EXACT []

[Term]
id: sgd:S000004700
name: YMR094W
def: "Subunit of the CBF3 complex; CBF3 binds to the CDE III element of centromeres\, bending the DNA upon binding\, and may be involved in sister chromatid cohesion during mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF3C" EXACT []
synonym: "CTF13" EXACT []

[Term]
id: sgd:S000004701
name: YMR095C
def: "Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p\, with Sno1p serving as the glutaminase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNO1" EXACT []

[Term]
id: sgd:S000004702
name: YMR096W
def: "Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p\, perhaps as a multiprotein complex containing other Snz and Sno proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNZ1" EXACT []
synonym: "pyridoxine biosynthesis protein SNZ1" EXACT []

[Term]
id: sgd:S000004703
name: YMR097C
def: "Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence\, likely functions in assembly of the large ribosomal subunit\, has homologs in plants and animals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTG1" EXACT []
synonym: "putative GTPase MTG1" EXACT []

[Term]
id: sgd:S000004704
name: YMR098C
def: "Mitochondrial protein required for the stability of Oli1p \(Atp9p\) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP25" EXACT []
synonym: "LRC4" EXACT []

[Term]
id: sgd:S000004705
name: YMR099C
def: "Glucose-6-phosphate 1-epimerase \(hexose-6-phosphate mutarotase\); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "glucose-6-phosphate 1-epimerase" EXACT []

[Term]
id: sgd:S000004706
name: YMR100W
def: "MYND domain-containing protein; required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p \(E3\) and indirectly with Rad6p \(E2\); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUB1" EXACT []

[Term]
id: sgd:S000004707
name: YMR101C
def: "Cis-prenyltransferase; involved in synthesis of long-chain dolichols \(19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols\); localizes to lipid bodies; transcription is induced during stationary phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRT1" EXACT []

[Term]
id: sgd:S000004708
name: YMR102C
def: "Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; not an essential gene; YMR102C has a paralog\, DGR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004709
name: YMR103C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004710
name: YMR104C
def: "Protein kinase similar to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog\, YPK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YKR2" EXACT []
synonym: "YPK2" EXACT []
synonym: "putative protein kinase YPK2" EXACT []

[Term]
id: sgd:S000004711
name: YMR105C
def: "Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate\, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog\, PGM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL5" EXACT []
synonym: "PGM2" EXACT []
synonym: "phosphoglucomutase PGM2" EXACT []

[Term]
id: sgd:S000004712
name: YMR106C
def: "Subunit of the telomeric Ku complex \(Yku70p-Yku80p\); involved in telomere length maintenance\, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDF2" EXACT []
synonym: "YKU80" EXACT []

[Term]
id: sgd:S000004713
name: YMR107W
def: "Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPG4" EXACT []

[Term]
id: sgd:S000004714
name: YMR108W
def: "Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors\, localizes to the mitochondria; expression of the gene is under general amino acid control" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ILV2" EXACT []
synonym: "SMR1" EXACT []
synonym: "THI1" EXACT []
synonym: "acetolactate synthase catalytic subunit" EXACT []

[Term]
id: sgd:S000004715
name: YMR109W
def: "One of two type I myosin motors; contains proline-rich tail homology 2 \(TH2\) and SH3 domains; MYO5 deletion has little effect on growth\, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog\, MYO3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MYO5" EXACT []
synonym: "myosin 5" EXACT []

[Term]
id: sgd:S000004716
name: YMR110C
def: "Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2\, a human fatty aldehyde dehydrogenase \(FALDH\) mutated in Sjogren-Larsson syndrome\, a neurocutaneous disorder" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HFD1" EXACT []

[Term]
id: sgd:S000004717
name: YMR111C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004718
name: YMR112C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED11" EXACT []

[Term]
id: sgd:S000004719
name: YMR113W
def: "Dihydrofolate synthetase\, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog\, RMA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOL3" EXACT []
synonym: "dihydrofolate synthase" EXACT []

[Term]
id: sgd:S000004720
name: YMR114C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004721
name: YMR115W
def: "Subunit of the mitochondrial \(mt\) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP24" EXACT []
synonym: "MGR3" EXACT []

[Term]
id: sgd:S000004722
name: YMR116C
def: "G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small \(40S\) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASC1" EXACT []
synonym: "ASU9" EXACT []
synonym: "CPC2" EXACT []
synonym: "NAD1" EXACT []
synonym: "guanine nucleotide-binding protein subunit beta" EXACT []

[Term]
id: sgd:S000004723
name: YMR117C
def: "Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation\, spindle checkpoint activity\, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p\, Nuf2p\, Spc24p\, and Spc25p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC24" EXACT []

[Term]
id: sgd:S000004724
name: YMR118C
def: "Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p\, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog\, SDH3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHH3" EXACT []
synonym: "protein SHH3" EXACT []

[Term]
id: sgd:S000004725
name: YMR119W
def: "Subunit of the nuclear inner membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by targeting latent unprocessed forms of Stp1p and Stp2p and maintains the repressed state of gene expression in the absence of inducing amino acids; ASI1 has a paralog\, ASI3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASI1" EXACT []
synonym: "putative ubiquitin-protein ligase ASI1" EXACT []

[Term]
id: sgd:S000004726
name: YMR119W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 3' end of ORF ASI1/YMR119W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004727
name: YMR120C
def: "Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog\, ADE16\, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE17" EXACT []
synonym: "bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17" EXACT []

[Term]
id: sgd:S000004728
name: YMR121C
def: "Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15\, no bacterial homolog; RPL15B has a paralog\, RPL15A\, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13B" EXACT []
synonym: "L15B" EXACT []
synonym: "L15e" EXACT []
synonym: "RPL15B" EXACT []
synonym: "YL10" EXACT []
synonym: "ribosomal 60S subunit protein L15B" EXACT []
synonym: "rp15R" EXACT []

[Term]
id: sgd:S000004729
name: YMR122C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004730
name: YMR123W
def: "V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector \(V0\); protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKR1" EXACT []

[Term]
id: sgd:S000004731
name: YMR124W
def: "Protein involved in septin-ER tethering; interacts with ER membrane protein\, Scs2p\, and Shs1p\, a septin ring component\, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery\, cytoplasm\, bud\, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog\, YLR031W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EPO1" EXACT []

[Term]
id: sgd:S000004732
name: YMR125W
def: "Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly\(A\)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBC1" EXACT []
synonym: "CBP80" EXACT []
synonym: "GCR3" EXACT []
synonym: "STO1" EXACT []
synonym: "SUT1" EXACT []

[Term]
id: sgd:S000004733
name: YMR126C
def: "Protein of unknown function; mutant sensitive to 6-azauracil \(6AU\) and mycophenolic acid \(MPA\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DLT1" EXACT []

[Term]
id: sgd:S000004734
name: YMR127C
def: "Histone acetyltransferase \(HAT\) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAT8" EXACT []
synonym: "SAS2" EXACT []

[Term]
id: sgd:S000004735
name: YMR128W
def: "Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHR1" EXACT []
synonym: "ECM16" EXACT []

[Term]
id: sgd:S000004736
name: YMR129W
def: "Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport\, nuclear pore complex \(NPC\) biogenesis and spindle pole body duplication; homologous to human NUP210" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POM152" EXACT []

[Term]
id: sgd:S000004737
name: YMR130W
def: "Putative protein of unknown function; YMR130W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004738
name: YMR131C
def: "Nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRB1" EXACT []

[Term]
id: sgd:S000004739
name: YMR132C
def: "Protein of unknown function; contains sequence that closely resembles a J domain \(typified by the E. coli DnaJ protein\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JLP2" EXACT []

[Term]
id: sgd:S000004740
name: YMR133W
def: "Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REC114" EXACT []

[Term]
id: sgd:S000004741
name: YMR134W
def: "Protein of unknown function involved in ergosterol biosynthesis; conditional mutants produce less ergosterol\, display impaired oxygen consumption\, respiratory growth\, mitochondrial iron utilization\, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm\, ER and nuclear envelope; highly conserved in ascomycetes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG29" EXACT []

[Term]
id: sgd:S000004742
name: YMR135C
def: "Subunit of GID Complex\, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1\,6-bisphosphatase; recruits Rmd5p\, Fyv10 and Vid28p to GID Complex; contains LisH\, CTLH\, and CRA domains that mediate binding to Vid30p \(LisH\) and Rmd5p and Vid28p \(CTLH and CRA\); dosage-dependent regulator of START" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCR1" EXACT []
synonym: "GID8" EXACT []
synonym: "glucose-induced degradation complex subunit GID8" EXACT []

[Term]
id: sgd:S000004743
name: YMR135W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004744
name: YMR136W
def: "Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAT2" EXACT []

[Term]
id: sgd:S000004745
name: YMR137C
def: "Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSO2" EXACT []
synonym: "SNM1" EXACT []

[Term]
id: sgd:S000004746
name: YMR138W
def: "GTP-binding protein involved in beta-tubulin \(Tub2p\) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein\, Cin2p\, the human retinitis pigmentosa 2 \(RP2\) homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family GTPase CIN4" EXACT []
synonym: "CIN4" EXACT []
synonym: "GTP1" EXACT []
synonym: "UGX1" EXACT []

[Term]
id: sgd:S000004747
name: YMR139W
def: "Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog\, MRK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSK3" EXACT []
synonym: "MDS1" EXACT []
synonym: "RIM11" EXACT []
synonym: "serine/threonine protein kinase RIM11" EXACT []

[Term]
id: sgd:S000004748
name: YMR140W
def: "Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP5" EXACT []

[Term]
id: sgd:S000004749
name: YMR141C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004750
name: YMR142C
def: "Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13\, no bacterial homolog; RPL13B has a paralog\, RPL13A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13B" EXACT []
synonym: "L13e" EXACT []
synonym: "RPL13B" EXACT []
synonym: "ribosomal 60S subunit protein L13B" EXACT []

[Term]
id: sgd:S000004751
name: YMR143W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog\, RPS16B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS16A" EXACT []
synonym: "S16A" EXACT []
synonym: "S9" EXACT []
synonym: "ribosomal 40S subunit protein S16A" EXACT []
synonym: "rp61R" EXACT []

[Term]
id: sgd:S000004752
name: YMR144W
def: "Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004753
name: YMR145C
def: "Mitochondrial external NADH dehydrogenase; type II NAD\(P\)H\:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog\, NDE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NADH-ubiquinone reductase (H(+)-translocating) NDE1" EXACT []
synonym: "NDE1" EXACT []
synonym: "NDH1" EXACT []

[Term]
id: sgd:S000004754
name: YMR146C
def: "eIF3i subunit of the eukaryotic translation initiation factor 3 \(eIF3\); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF34" EXACT []
synonym: "translation initiation factor eIF3 subunit i" EXACT []

[Term]
id: sgd:S000004755
name: YMR147W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004756
name: YMR148W
def: "Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSW5" EXACT []

[Term]
id: sgd:S000004757
name: YMR149W
def: "Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWP1" EXACT []

[Term]
id: sgd:S000004758
name: YMR150C
def: "Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits \(Imp1p and Imp2p that differ in substrate specificty\) and Som1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP1" EXACT []
synonym: "PET-TS2858" EXACT []

[Term]
id: sgd:S000004759
name: YMR151W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIM2" EXACT []

[Term]
id: sgd:S000004760
name: YMR152W
def: "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism\, based on localization to lipid droplets; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIM1" EXACT []

[Term]
id: sgd:S000004761
name: YMR153C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps 3' end of verified gene NUP53/YMR153W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004762
name: YMR153W
def: "FG-nucleoporin component of central core of nuclear pore complex \(NPC\); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation\, which may contribute to nuclear pore assembly; NUP53 has a paralog\, ASM4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP53" EXACT []
synonym: "NUP53" EXACT []

[Term]
id: sgd:S000004763
name: YMR154C
def: "Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPL1" EXACT []
synonym: "RIM13" EXACT []

[Term]
id: sgd:S000004764
name: YMR155W
def: "Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004765
name: YMR156C
def: "DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA\, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPP1" EXACT []

[Term]
id: sgd:S000004766
name: YMR157C
def: "Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic\, non-tagged protein is detected in purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM36" EXACT []
synonym: "FMP39" EXACT []

[Term]
id: sgd:S000004767
name: YMR158W
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS8" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS8" EXACT []

[Term]
id: sgd:S000004768
name: YMR158W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMR158W-A" EXACT []

[Term]
id: sgd:S000004769
name: YMR159C
def: "Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers\, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG15" EXACT []
synonym: "APG16" EXACT []
synonym: "ATG16" EXACT []
synonym: "CVT11" EXACT []
synonym: "SAP18" EXACT []

[Term]
id: sgd:S000004770
name: YMR160W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004771
name: YMR161W
def: "Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation \(ERAD\) of integral membrane substrates; similar to E. coli DnaJ" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HLJ1" EXACT []

[Term]
id: sgd:S000004772
name: YMR162C
def: "Trans-golgi network aminophospholipid translocase \(flippase\); type 4 P-type ATPase; involved in phospholipid translocation\, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNF3" EXACT []
synonym: "aminophospholipid-translocating P4-type ATPase DNF3" EXACT []

[Term]
id: sgd:S000004773
name: YMR163C
def: "Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP2" EXACT []

[Term]
id: sgd:S000004774
name: YMR164C
def: "Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1\, FLO11\, and STA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS11" EXACT []

[Term]
id: sgd:S000004775
name: YMR165C
def: "Mg2+-dependent phosphatidate \(PA\) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAH1" EXACT []
synonym: "SMP2" EXACT []
synonym: "phosphatidate phosphatase PAH1" EXACT []

[Term]
id: sgd:S000004776
name: YMR166C
def: "Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004777
name: YMR167W
def: "Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLH1" EXACT []
synonym: "PMS2" EXACT []
synonym: "mismatch repair ATPase MLH1" EXACT []

[Term]
id: sgd:S000004778
name: YMR168C
def: "Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain\, a C-terminal acidic domain\, and a putative coiled coil dimerization domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBF3" EXACT []
synonym: "CBF3B" EXACT []
synonym: "CEP3" EXACT []
synonym: "CSL1" EXACT []

[Term]
id: sgd:S000004779
name: YMR169C
def: "Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALD3" EXACT []
synonym: "aldehyde dehydrogenase (NAD(+)) ALD3" EXACT []

[Term]
id: sgd:S000004780
name: YMR170C
def: "Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALD2" EXACT []
synonym: "aldehyde dehydrogenase (NAD(+)) ALD2" EXACT []

[Term]
id: sgd:S000004781
name: YMR171C
def: "Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAR1" EXACT []

[Term]
id: sgd:S000004782
name: YMR172C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF HOT1/YMR172W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004783
name: YMR172W
def: "Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOT1" EXACT []

[Term]
id: sgd:S000004784
name: YMR173W
def: "DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDR48" EXACT []
synonym: "DNA damage-responsive protein 48" EXACT []
synonym: "FSP" EXACT []

[Term]
id: sgd:S000004785
name: YMR173W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004786
name: YMR174C
def: "Cytoplasmic proteinase A \(Pep4p\) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured\, N-terminal half becomes ordered in the active site of proteinase A upon contact" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IA3" EXACT []
synonym: "PAI3" EXACT []

[Term]
id: sgd:S000004787
name: YMR175W
def: "Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog\, GRE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP18" EXACT []

[Term]
id: sgd:S000004788
name: YMR176W
def: "Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p\, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p\, independently of Rpd3p\, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume\, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM5" EXACT []

[Term]
id: sgd:S000004789
name: YMR177W
def: "Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog\, MMT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFT1" EXACT []
synonym: "MMT1" EXACT []

[Term]
id: sgd:S000004790
name: YMR178W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004791
name: YMR179W
def: "Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2\, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPT21" EXACT []

[Term]
id: sgd:S000004792
name: YMR180C
def: "RNA 5'-triphosphatase\, localizes to both the nucleus and cytoplasm; CTL1 has a paralog\, CET1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTH1" EXACT []
synonym: "CTL1" EXACT []

[Term]
id: sgd:S000004793
name: YMR181C
def: "Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay \(NMD\); not an essential gene; YMR181C has a paralog\, YPL229W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004794
name: YMR182C
def: "Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog\, USV1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGM1" EXACT []

[Term]
id: sgd:S000004795
name: YMR183C
def: "Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog\, SSO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSO2" EXACT []

[Term]
id: sgd:S000004796
name: YMR184W
def: "Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADD37" EXACT []

[Term]
id: sgd:S000004797
name: YMR185W
def: "Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds\, or inviable; interacts with Rpb2\, Rpb3\, Nup116p\, Nup100p and components of the R2TP complex \(Rvb1p\, Rvb2p\, Pih1p\); similar to human TMCO7 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTP1" EXACT []

[Term]
id: sgd:S000004798
name: YMR186W
def: "Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p\, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog\, HSP82\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSC82" EXACT []
synonym: "HSP90" EXACT []
synonym: "Hsp90 family chaperone HSC82" EXACT []

[Term]
id: sgd:S000004799
name: YMR187C
def: "Putative protein of unknown function; YMR187C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004800
name: YMR188C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS17" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS17" EXACT []

[Term]
id: sgd:S000004801
name: YMR189W
def: "P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5\,10-methylene-THF; expression is regulated by levels of 5\,10-methylene-THF in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCV2" EXACT []
synonym: "GSD2" EXACT []
synonym: "glycine decarboxylase subunit P" EXACT []

[Term]
id: sgd:S000004802
name: YMR190C
def: "RecQ family nucleolar DNA helicase; role in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; stimulates DNA catenation/decatenation activity of Top3p; potential repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent DNA helicase SGS1" EXACT []
synonym: "SGS1" EXACT []

[Term]
id: sgd:S000004803
name: YMR191W
def: "Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPG5" EXACT []

[Term]
id: sgd:S000004804
name: YMR192W
def: "Putative GTPase activating protein \(GAP\) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p\, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p\, Rvs161p\, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog\, GYP5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APP2" EXACT []
synonym: "GYL1" EXACT []

[Term]
id: sgd:S000004805
name: YMR193C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004806
name: YMR193W
def: "Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins\, YmL14 and YmL24\, have been assigned to the same gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL14" EXACT []
synonym: "MRPL24" EXACT []
synonym: "YmL14" EXACT []
synonym: "YmL24" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL24/YmL14" EXACT []

[Term]
id: sgd:S000004807
name: YMR194W
def: "Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36\, no bacterial homolog; RPL36A has a paralog\, RPL36B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L36A" EXACT []
synonym: "L36e" EXACT []
synonym: "L39" EXACT []
synonym: "RPL36A" EXACT []
synonym: "RPL39B" EXACT []
synonym: "YL39" EXACT []
synonym: "ribosomal 60S subunit protein L36A" EXACT []

[Term]
id: sgd:S000004808
name: YMR195W
def: "Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog\, ICY2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICY1" EXACT []

[Term]
id: sgd:S000004809
name: YMR196W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004810
name: YMR197C
def: "Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES\, Sed5p and Pep12p; required for multiple vacuolar sorting pathways" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VTI1" EXACT []

[Term]
id: sgd:S000004811
name: YMR198W
def: "Kinesin-associated protein; required for both karyogamy and mitotic spindle organization\, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog\, VIK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIK1" EXACT []

[Term]
id: sgd:S000004812
name: YMR199W
def: "G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes\, MBF \(Swi6p-Mbp1p\) and SBF \(Swi6p-Swi4p\); CLN1 has a paralog\, CLN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLN1" EXACT []
synonym: "cyclin CLN1" EXACT []

[Term]
id: sgd:S000004813
name: YMR200W
def: "Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies\, suppresses tor2 mutations\, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role\, avoiding exposure of Ser H-bonding group at lipid-exposed surface" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROT1" EXACT []

[Term]
id: sgd:S000004814
name: YMR201C
def: "Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 \(NEF1\); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotide excision repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD14" EXACT []

[Term]
id: sgd:S000004815
name: YMR202W
def: "C-8 sterol isomerase; catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C-8 sterol isomerase ERG2" EXACT []
synonym: "END11" EXACT []
synonym: "ERG2" EXACT []

[Term]
id: sgd:S000004816
name: YMR203W
def: "Component of the TOM \(translocase of outer membrane\) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA\, which impairs its import into mitochondria under non-respiratory conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISP42" EXACT []
synonym: "MOM38" EXACT []
synonym: "TOM40" EXACT []

[Term]
id: sgd:S000004817
name: YMR204C
def: "Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP1" EXACT []

[Term]
id: sgd:S000004818
name: YMR205C
def: "Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2\,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-phosphofructokinase subunit beta" EXACT []
synonym: "PFK2" EXACT []

[Term]
id: sgd:S000004819
name: YMR206W
def: "Putative protein of unknown function; not an essential gene; YMR206W has a paralog\, YNR014W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004820
name: YMR207C
def: "Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical \(Ile\) start codon at -372 relative to the annotated start codon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HFA1" EXACT []
synonym: "acetyl-CoA carboxylase HFA1" EXACT []

[Term]
id: sgd:S000004821
name: YMR208W
def: "Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols\, including ergosterol\, from mevalonate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG12" EXACT []
synonym: "RAR1" EXACT []
synonym: "mevalonate kinase" EXACT []

[Term]
id: sgd:S000004822
name: YMR209C
def: "Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004823
name: YMR210W
def: "Putative acyltransferase with similarity to Eeb1p and Eht1p; has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative carboxylic ester hydrolase" EXACT []

[Term]
id: sgd:S000004824
name: YMR211W
def: "Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes\, exhibits regions similar to members of a GTPase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DML1" EXACT []

[Term]
id: sgd:S000004825
name: YMR212C
def: "Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide \(PI\) kinase patch assembly at the plasma membrane; recruited to the plasma membrane via a conserved basic patch near its N-terminus; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout \(RBO\) gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFR3" EXACT []

[Term]
id: sgd:S000004826
name: YMR213W
def: "Essential splicing factor; associated with Prp19p and the spliceosome\, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association\, evolutionarily conserved and homologous to S. pombe Cdc5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEF1" EXACT []
synonym: "NTC85" EXACT []

[Term]
id: sgd:S000004827
name: YMR214W
def: "One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCJ1" EXACT []

[Term]
id: sgd:S000004828
name: YMR215W
def: "Putative 1\,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance\, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAS3" EXACT []

[Term]
id: sgd:S000004829
name: YMR216C
def: "SR protein kinase \(SRPK\); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKY1" EXACT []
synonym: "serine/threonine protein kinase SKY1" EXACT []

[Term]
id: sgd:S000004830
name: YMR217W
def: "GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate \(IMP\); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools\, defects in general protein synthesis\, and impaired translation of GCN4 mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GMP synthase (glutamine-hydrolyzing)" EXACT []
synonym: "GUA1" EXACT []

[Term]
id: sgd:S000004831
name: YMR218C
def: "Component of transport protein particle \(TRAPP\) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating intra-Golgi and endosome-Golgi traffic" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS130" EXACT []

[Term]
id: sgd:S000004832
name: YMR219W
def: "Protein localized to the nuclear periphery; involved in telomeric silencing; interacts with PAD4-domain of Sir4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESC1" EXACT []

[Term]
id: sgd:S000004833
name: YMR220W
def: "Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols\, including ergosterol\, from mevalonate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG8" EXACT []
synonym: "phosphomevalonate kinase" EXACT []

[Term]
id: sgd:S000004834
name: YMR221C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004835
name: YMR222C
def: "Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FSH2" EXACT []

[Term]
id: sgd:S000004836
name: YMR223W
def: "Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA \(Spt-Ada-Gcn5-Acetyltransferase\)-mediated deubiquitination of histone H2B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP8" EXACT []
synonym: "ubiquitin-specific protease UBP8" EXACT []

[Term]
id: sgd:S000004837
name: YMR224C
def: "Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRE11" EXACT []
synonym: "MRX complex nuclease subunit" EXACT []
synonym: "NGS1" EXACT []
synonym: "RAD58" EXACT []
synonym: "XRS4" EXACT []

[Term]
id: sgd:S000004838
name: YMR225C
def: "Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL44" EXACT []
synonym: "YMR44" EXACT []
synonym: "YmL44" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL44" EXACT []

[Term]
id: sgd:S000004839
name: YMR226C
def: "NADP\(+\)-dependent serine dehydrogenase and carbonyl reductase; acts on serine\, L-allo-threonine\, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMA29" EXACT []
synonym: "oxidoreductase" EXACT []

[Term]
id: sgd:S000004840
name: YMR227C
def: "TFIID subunit \(67 kDa\); involved in RNA polymerase II transcription initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF67" EXACT []
synonym: "TAF7" EXACT []
synonym: "TafII67" EXACT []

[Term]
id: sgd:S000004841
name: YMR228W
def: "Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex\, enhancing DNA bending and melting to facilitate pre-initiation open complex formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTF1" EXACT []

[Term]
id: sgd:S000004842
name: YMR229C
def: "RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit \(SSU\) processosome and the 90S preribosome; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP5" EXACT []

[Term]
id: sgd:S000004843
name: YMR230W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S10\, no bacterial homolog; RPS10B has a paralog\, RPS10A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS10B" EXACT []
synonym: "S10B" EXACT []
synonym: "S10e" EXACT []
synonym: "ribosomal 40S subunit protein S10B" EXACT []

[Term]
id: sgd:S000004844
name: YMR231W
def: "Histone E3 ligase\, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitylation and degradation of excess histones" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END1" EXACT []
synonym: "PEP5" EXACT []
synonym: "VAM1" EXACT []
synonym: "VPL9" EXACT []
synonym: "VPS11" EXACT []
synonym: "VPT11" EXACT []
synonym: "tethering complex subunit PEP5" EXACT []

[Term]
id: sgd:S000004845
name: YMR232W
def: "Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUS2" EXACT []

[Term]
id: sgd:S000004846
name: YMR233W
def: "Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm\, nucleus and nucleolus; TRI1 has a paralog\, UAF30\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRI1" EXACT []

[Term]
id: sgd:S000004847
name: YMR234W
def: "Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNH1" EXACT []

[Term]
id: sgd:S000004848
name: YMR235C
def: "GTPase activating protein \(GAP\) for Gsp1p; involved in nuclear transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNA1" EXACT []

[Term]
id: sgd:S000004849
name: YMR236W
def: "Subunit \(17 kDa\) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification\, similar to histone H3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF17" EXACT []
synonym: "TAF9" EXACT []
synonym: "TATA-binding protein-associated factor TAF9" EXACT []
synonym: "TafII17" EXACT []

[Term]
id: sgd:S000004850
name: YMR237W
def: "Member of the ChAPs family \(Chs5p-Arf1p-binding proteins\); members include Bch1p\, Bch2p\, Bud7p\, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog\, BUD7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCH1" EXACT []

[Term]
id: sgd:S000004851
name: YMR238W
def: "Putative mannosidase; essential glycosylphosphatidylinositol \(GPI\)-anchored membrane protein required for cell wall biogenesis in bud formation\, involved in filamentous growth\, homologous to Dcw1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFG5" EXACT []

[Term]
id: sgd:S000004852
name: YMR239C
def: "Nuclear dsRNA-specific ribonuclease \(RNase III\); involved in rDNA transcription\, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response\, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNT1" EXACT []

[Term]
id: sgd:S000004853
name: YMR240C
def: "Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUS1" EXACT []

[Term]
id: sgd:S000004854
name: YMR241W
def: "Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion\, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YHM2" EXACT []

[Term]
id: sgd:S000004855
name: YMR242C
def: "Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A\, no bacterial homolog; RPL20A has a paralog\, RPL20B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L18A" EXACT []
synonym: "L20A" EXACT []
synonym: "L20e" EXACT []
synonym: "RPL18A2" EXACT []
synonym: "RPL20A" EXACT []
synonym: "ribosomal 60S subunit protein L20A" EXACT []

[Term]
id: sgd:S000004856
name: YMR243C
def: "Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog\, COT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSR1" EXACT []
synonym: "ZRC1" EXACT []
synonym: "Zn(2+) transporter ZRC1" EXACT []

[Term]
id: sgd:S000004857
name: YMR244C-A
def: "Protein involved in cytochrome c oxidase \(Complex IV\) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COA6" EXACT []

[Term]
id: sgd:S000004858
name: YMR244W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004859
name: YMR245W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004860
name: YMR246W
def: "Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12\:0-C16\:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog\, FAA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAA4" EXACT []
synonym: "long-chain fatty acid-CoA ligase FAA4" EXACT []

[Term]
id: sgd:S000004861
name: YMR247C
def: "RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins; component of ribosome-bound RQC \(ribosome quality control\) complex required for degradation of polypeptides arising from stalled translation; degrades products of mRNAs lacking a termination codon regardless of a poly\(A\) tail; functional connections to chromatin modification; homolog of mouse Listerin\, mutations in which reported to cause neurodegeneration" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTN1" EXACT []
synonym: "RKR1" EXACT []
synonym: "ubiquitin-protein ligase RKR1" EXACT []

[Term]
id: sgd:S000004862
name: YMR250W
def: "Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid \(GABA\) during glutamate catabolism; involved in response to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAD1" EXACT []
synonym: "glutamate decarboxylase GAD1" EXACT []

[Term]
id: sgd:S000004863
name: YMR251W
def: "Omega class glutathione transferase; putative cytosolic localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTO3" EXACT []

[Term]
id: sgd:S000004864
name: YMR251W-A
def: "Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog\, DDR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOR7" EXACT []

[Term]
id: sgd:S000004865
name: YMR252C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YMR252C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004866
name: YMR253C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004867
name: YMR254C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004868
name: YMR255W
def: "Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GFD1" EXACT []

[Term]
id: sgd:S000004869
name: YMR256C
def: "Subunit VII of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX7" EXACT []
synonym: "cytochrome c oxidase subunit VII" EXACT []

[Term]
id: sgd:S000004870
name: YMR257C
def: "Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET111" EXACT []

[Term]
id: sgd:S000004871
name: YMR258C
def: "GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ROY1" EXACT []

[Term]
id: sgd:S000004872
name: YMR259C
def: "Protein that interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; non-essential gene; functionally complemented by human THADA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM732" EXACT []

[Term]
id: sgd:S000004873
name: YMR260C
def: "Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p \(eIF1\) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p \(eIF5B\); N terminus interacts with eIF2 and eIF3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIF11" EXACT []

[Term]
id: sgd:S000004874
name: YMR261C
def: "Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog\, TSL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPS3" EXACT []

[Term]
id: sgd:S000004875
name: YMR262W
def: "Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004876
name: YMR263W
def: "Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres\, rDNA\, and silent mating-type loci; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAP30" EXACT []

[Term]
id: sgd:S000004877
name: YMR264W
def: "Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog\, CUE4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUE1" EXACT []
synonym: "KIS4" EXACT []

[Term]
id: sgd:S000004878
name: YMR265C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004879
name: YMR266W
def: "Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump \(Ena1p\) localization to the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSN1" EXACT []

[Term]
id: sgd:S000004880
name: YMR267W
def: "Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPP2" EXACT []
synonym: "PPA2" EXACT []
synonym: "inorganic diphosphatase PPA2" EXACT []

[Term]
id: sgd:S000004881
name: YMR268C
def: "Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP24" EXACT []

[Term]
id: sgd:S000004882
name: YMR269W
def: "Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMA23" EXACT []
synonym: "YMR268W-A" EXACT []

[Term]
id: sgd:S000004883
name: YMR270C
def: "Protein involved in promoting high level transcription of rDNA; subunit of UAF \(upstream activation factor\) for RNA polymerase I" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRN9" EXACT []

[Term]
id: sgd:S000004884
name: YMR271C
def: "Minor orotate phosphoribosyltransferase \(OPRTase\) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines\, converting orotate into orotidine-5'-phosphate; URA10 has a paralog\, URA5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URA10" EXACT []
synonym: "orotate phosphoribosyltransferase URA10" EXACT []

[Term]
id: sgd:S000004885
name: YMR272C
def: "Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids\, has both cytochrome b5-like and hydroxylase/desaturase domains\, not essential for growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAH1" EXACT []
synonym: "SCS7" EXACT []
synonym: "fatty acid alpha-hydroxylase" EXACT []

[Term]
id: sgd:S000004886
name: YMR273C
def: "Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog\, ZDS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CES1" EXACT []
synonym: "CKM1" EXACT []
synonym: "NRC1" EXACT []
synonym: "OSS1" EXACT []
synonym: "ZDS1" EXACT []

[Term]
id: sgd:S000004887
name: YMR274C
def: "Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCE1" EXACT []

[Term]
id: sgd:S000004888
name: YMR275C
def: "Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth\, overexpression causes missorting of amino acid permeases; BUL1 has a paralog\, BUL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUL1" EXACT []
synonym: "DAG1" EXACT []
synonym: "RDS1" EXACT []
synonym: "SMM2" EXACT []
synonym: "ubiquitin-ubiquitin ligase BUL1" EXACT []

[Term]
id: sgd:S000004889
name: YMR276W
def: "Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body \(SPB\) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSK2" EXACT []

[Term]
id: sgd:S000004890
name: YMR277W
def: "Carboxy-terminal domain \(CTD\) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit \(Rpo21p\); relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCP1" EXACT []

[Term]
id: sgd:S000004891
name: YMR278W
def: "Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; non-essential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGM3" EXACT []
synonym: "PRM15" EXACT []
synonym: "phosphoribomutase PRM15" EXACT []

[Term]
id: sgd:S000004892
name: YMR279C
def: "Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog\, ATR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004893
name: YMR280C
def: "Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions\, active after diauxic shift\, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAT8" EXACT []
synonym: "DIL1" EXACT []
synonym: "DNA-binding transcription factor CAT8" EXACT []
synonym: "MSP8" EXACT []

[Term]
id: sgd:S000004894
name: YMR281W
def: "ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI12" EXACT []

[Term]
id: sgd:S000004895
name: YMR282C
def: "Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AEP2" EXACT []
synonym: "ATP13" EXACT []

[Term]
id: sgd:S000004896
name: YMR283C
def: "Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIT1" EXACT []

[Term]
id: sgd:S000004897
name: YMR284W
def: "Subunit of the telomeric Ku complex \(Yku70p-Yku80p\); involved in telomere length maintenance\, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDF1" EXACT []
synonym: "KU70" EXACT []
synonym: "NES24" EXACT []
synonym: "YKU70" EXACT []

[Term]
id: sgd:S000004898
name: YMR285C
def: "Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog\, NGL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NGL2" EXACT []

[Term]
id: sgd:S000004899
name: YMR286W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL33" EXACT []
synonym: "YmL33" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL33" EXACT []

[Term]
id: sgd:S000004900
name: YMR287C
def: "3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSS1" EXACT []
synonym: "MSU1" EXACT []

[Term]
id: sgd:S000004901
name: YMR288W
def: "U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSH155" EXACT []

[Term]
id: sgd:S000004902
name: YMR289W
def: "Aminodeoxychorismate lyase \(4-amino-4-deoxychorismate lyase\); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABZ2" EXACT []
synonym: "aminodeoxychorismate lyase ABZ2" EXACT []

[Term]
id: sgd:S000004903
name: YMR290C
def: "ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase HAS1" EXACT []
synonym: "HAS1" EXACT []

[Term]
id: sgd:S000004904
name: YMR290W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1/YMR290C gene which encodes an ATP-dependent RNA helicase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004905
name: YMR291W
def: "Protein kinase of unknown cellular role; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA1" EXACT []
synonym: "protein kinase TDA1" EXACT []

[Term]
id: sgd:S000004906
name: YMR292W
def: "Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GOT1" EXACT []

[Term]
id: sgd:S000004907
name: YMR293C
def: "Subunit of the trimeric GatFAB AmidoTransferase\(AdT\) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GEP6" EXACT []
synonym: "HER2" EXACT []
synonym: "LRC6" EXACT []
synonym: "RRG6" EXACT []
synonym: "glutamyl-tRNA(Gln) amidotransferase subunit HER2" EXACT []

[Term]
id: sgd:S000004908
name: YMR294W
def: "Component of the yeast dynactin complex; consisting of Nip100p\, Jnm1p\, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INS1" EXACT []
synonym: "JNM1" EXACT []
synonym: "PAC3" EXACT []

[Term]
id: sgd:S000004909
name: YMR294W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004910
name: YMR295C
def: "Protein of unknown function that associates with ribosomes; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog\, YGR273C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IBI2" EXACT []

[Term]
id: sgd:S000004911
name: YMR296C
def: "Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis\, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END8" EXACT []
synonym: "LCB1" EXACT []
synonym: "TSC2" EXACT []
synonym: "serine C-palmitoyltransferase LCB1" EXACT []

[Term]
id: sgd:S000004912
name: YMR297W
def: "Vacuolar carboxypeptidase Y \(proteinase C\, CPY\); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPY" EXACT []
synonym: "CPY1" EXACT []
synonym: "LBC1" EXACT []
synonym: "PRC1" EXACT []
synonym: "carboxypeptidase C PRC1" EXACT []

[Term]
id: sgd:S000004913
name: YMR298W
def: "Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity\, null mutant grows extremely slowly and is defective in ceramide synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIP1" EXACT []
synonym: "sphingosine N-acyltransferase subunit LIP1" EXACT []

[Term]
id: sgd:S000004914
name: YMR299C
def: "Dynein light intermediate chain \(LIC\); localizes with dynein\, null mutant is defective in nuclear migration" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DYN3" EXACT []
synonym: "dynein light intermediate chain" EXACT []

[Term]
id: sgd:S000004915
name: YMR300C
def: "Phosphoribosylpyrophosphate amidotransferase \(PRPPAT\); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE4" EXACT []
synonym: "amidophosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000004916
name: YMR301C
def: "Mitochondrial inner membrane ATP-binding cassette \(ABC\) transporter; exports mitochondrially synthesized precursors of iron-sulfur \(Fe/S\) clusters to the cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATM1" EXACT []
synonym: "ATP-binding cassette Fe/S cluster precursor transporter ATM1" EXACT []

[Term]
id: sgd:S000004917
name: YMR302C
def: "Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP12" EXACT []
synonym: "RNA12" EXACT []
synonym: "YME2" EXACT []

[Term]
id: sgd:S000004918
name: YMR303C
def: "Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH2" EXACT []
synonym: "ADR2" EXACT []
synonym: "alcohol dehydrogenase ADH2" EXACT []

[Term]
id: sgd:S000004919
name: YMR304C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps 3' end of verified ORF SCW10/YMR305C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004920
name: YMR304W
def: "Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome \(APC/C\) activator\, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP15" EXACT []

[Term]
id: sgd:S000004921
name: YMR305C
def: "Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 has a paralog\, SCW4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCW10" EXACT []

[Term]
id: sgd:S000004922
name: YMR306C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF FKS3/YMR306W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004923
name: YMR306W
def: "Protein involved in spore wall assembly; has similarity to 1\,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-beta-D-glucan synthase" EXACT []
synonym: "FKS3" EXACT []
synonym: "putative 1" EXACT []

[Term]
id: sgd:S000004924
name: YMR307W
def: "Beta-1\,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol \(GPI\) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1" EXACT []
synonym: "3-beta-glucanosyltransferase GAS1" EXACT []
synonym: "CWH52" EXACT []
synonym: "GAS1" EXACT []
synonym: "GGP1" EXACT []

[Term]
id: sgd:S000004925
name: YMR308C
def: "Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins\, including Pdr1p\, Yap1p\, Ste12p\, and Aft1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP121" EXACT []
synonym: "PSE1" EXACT []

[Term]
id: sgd:S000004926
name: YMR309C
def: "eIF3c subunit of the eukaryotic translation initiation factor 3 \(eIF3\); involved in the assembly of preinitiation complex and start codon selection" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIP1" EXACT []

[Term]
id: sgd:S000004927
name: YMR310C
def: "Putative methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog\, YGR283C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004928
name: YMR311C
def: "Regulatory subunit of protein phosphatase 1 \(Glc7p\); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLC8" EXACT []

[Term]
id: sgd:S000004929
name: YMR312W
def: "Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP6" EXACT []
synonym: "Elongator subunit ELP6" EXACT []
synonym: "HAP3" EXACT []
synonym: "KTI4" EXACT []
synonym: "TOT6" EXACT []

[Term]
id: sgd:S000004930
name: YMR313C
def: "Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol \(TAG\) lipase; catalyzes acylation of lysophosphatidylethanolamine \(LPE\)\, a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TGL3" EXACT []

[Term]
id: sgd:S000004931
name: YMR314W
def: "Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE5" EXACT []
synonym: "proteasome core particle subunit alpha 6" EXACT []

[Term]
id: sgd:S000004932
name: YMR315W
def: "Protein with NADP\(H\) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004933
name: YMR316C-A
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004934
name: YMR316C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps 5' end of ORF YMR317W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004935
name: YMR316W
def: "Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIA1" EXACT []

[Term]
id: sgd:S000004936
name: YMR317W
def: "Putative protein of unknown function; has some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004937
name: YMR318C
def: "NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADH6" EXACT []
synonym: "ADHVI" EXACT []

[Term]
id: sgd:S000004938
name: YMR319C
def: "Low-affinity Fe\(II\) transporter of the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FET4" EXACT []

[Term]
id: sgd:S000004939
name: YMR320W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004940
name: YMR321C
def: "Putative protein of unknown function; proposed to be a palmitoylated membrane protein; YMR321C has a paralog\, SAM4\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004941
name: YMR322C
def: "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p\, Hsp32p\, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP34" EXACT []
synonym: "SNO4" EXACT []

[Term]
id: sgd:S000004942
name: YMR323W
def: "Enolase\, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERR3" EXACT []
synonym: "phosphopyruvate hydratase ERR3" EXACT []

[Term]
id: sgd:S000004943
name: YMR324C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004944
name: YMR325W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU19" EXACT []
synonym: "seripauperin PAU19" EXACT []

[Term]
id: sgd:S000004945
name: YMR326C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004946
name: YNL001W
def: "Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart\, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay\, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog\, YCL001W-B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOM34" EXACT []
synonym: "ribosome dissociation factor DOM34" EXACT []

[Term]
id: sgd:S000004947
name: YNL002C
def: "Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RLP7" EXACT []
synonym: "RPL7" EXACT []

[Term]
id: sgd:S000004948
name: YNL003C
def: "S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET8" EXACT []
synonym: "SAM5" EXACT []

[Term]
id: sgd:S000004949
name: YNL004W
def: "Poly\(A+\) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog\, GBP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRB1" EXACT []
synonym: "TOM34" EXACT []

[Term]
id: sgd:S000004950
name: YNL005C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP7" EXACT []
synonym: "MRPL2" EXACT []
synonym: "YmL2" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL2" EXACT []

[Term]
id: sgd:S000004951
name: YNL006W
def: "Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LST8" EXACT []
synonym: "TOR complex subunit LST8" EXACT []

[Term]
id: sgd:S000004952
name: YNL007C
def: "Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIS1" EXACT []
synonym: "type II HSP40 co-chaperone SIS1" EXACT []

[Term]
id: sgd:S000004953
name: YNL008C
def: "Subunit of the nuclear inner membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by targeting latent unprocessed forms of Stp1p and Stp2p and maintains the repressed state of gene expression in the absence of inducing amino acids; ASI3 has a paralog\, ASI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASI3" EXACT []
synonym: "putative ubiquitin-protein ligase ASI3" EXACT []

[Term]
id: sgd:S000004954
name: YNL009W
def: "Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP\(H+\)\, required for growth on unsaturated fatty acids; IDP3 has a paralog\, IDP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDP3" EXACT []
synonym: "isocitrate dehydrogenase (NADP(+)) IDP3" EXACT []

[Term]
id: sgd:S000004955
name: YNL010W
def: "Putative protein of unknown function; similar to phosphoserine phosphatases; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004956
name: YNL011C
def: "Putative protein of unknown function; YNL011C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004957
name: YNL012W
def: "Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO1" EXACT []

[Term]
id: sgd:S000004958
name: YNL013C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004959
name: YNL014W
def: "Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog\, YEF3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEF3" EXACT []
synonym: "ZRG7" EXACT []
synonym: "translation elongation factor EF-3" EXACT []

[Term]
id: sgd:S000004960
name: YNL015W
def: "Cytosolic inhibitor of vacuolar proteinase B \(PRB1\); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1\, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "I2B" EXACT []
synonym: "IB2" EXACT []
synonym: "LMA1" EXACT []
synonym: "PBI2" EXACT []

[Term]
id: sgd:S000004961
name: YNL016W
def: "Poly \(A\)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules\, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUB1" EXACT []
synonym: "RNP1" EXACT []

[Term]
id: sgd:S000004962
name: YNL017C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI\(AAU\)N2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004963
name: YNL018C
def: "Putative protein of unknown function; YNL018C has a paralog\, YNL034W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004964
name: YNL019C
def: "Putative protein of unknown function; expression induced during heat stress; YNL019C has a paralog\, YNL033W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004965
name: YNL020C
def: "Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog\, PRK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARK1" EXACT []
synonym: "serine/threonine protein kinase ARK1" EXACT []

[Term]
id: sgd:S000004966
name: YNL021W
def: "Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p\, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B\, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDA1" EXACT []
synonym: "histone deacetylase HDA1" EXACT []

[Term]
id: sgd:S000004967
name: YNL022C
def: "rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A\, a human gene which is deleted in Williams-Beuren Syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCM1" EXACT []

[Term]
id: sgd:S000004968
name: YNL023C
def: "Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAP1" EXACT []

[Term]
id: sgd:S000004969
name: YNL024C
def: "Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases\, null mutant does not display alterations in lysine methylation pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004970
name: YNL025C
def: "Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNC1" EXACT []
synonym: "CycC" EXACT []
synonym: "GIG3" EXACT []
synonym: "NUT9" EXACT []
synonym: "RYE2" EXACT []
synonym: "SRB11" EXACT []
synonym: "SSN8" EXACT []
synonym: "UME3" EXACT []

[Term]
id: sgd:S000004971
name: YNL026W
def: "Component of the Sorting and Assembly Machinery \(SAM\) complex; the SAM \(or TOB\) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OMP85" EXACT []
synonym: "SAM complex subunit SAM50" EXACT []
synonym: "SAM50" EXACT []
synonym: "TOB55" EXACT []

[Term]
id: sgd:S000004972
name: YNL027W
def: "Transcription factor\, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRZ1" EXACT []
synonym: "DNA-binding transcription factor CRZ1" EXACT []
synonym: "HAL8" EXACT []
synonym: "TCN1" EXACT []

[Term]
id: sgd:S000004973
name: YNL028W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004974
name: YNL029C
def: "Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog\, KTR7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR5" EXACT []

[Term]
id: sgd:S000004975
name: YNL030W
def: "Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins \(see also HHF1\); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HHF2" EXACT []
synonym: "histone H4" EXACT []

[Term]
id: sgd:S000004976
name: YNL031C
def: "Histone H3; core histone protein required for chromatin assembly\, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins \(see HHT1\); regulated by acetylation\, methylation\, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HHT2" EXACT []
synonym: "histone H3" EXACT []

[Term]
id: sgd:S000004977
name: YNL032W
def: "Tyrosine phosphatase involved in actin organization and endocytosis; localized to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA3" EXACT []
synonym: "SIW14" EXACT []
synonym: "putative tyrosine protein phosphatase SIW14" EXACT []

[Term]
id: sgd:S000004978
name: YNL033W
def: "Putative protein of unknown function; YNL033W has a paralog\, YNL019C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004979
name: YNL034W
def: "Putative protein of unknown function; not an essential gene; YNL034W has a paralog\, YNL018C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004980
name: YNL035C
def: "Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004981
name: YNL036W
def: "Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate\, which is an important metabolic substrate\, and protons; not expressed under conditions of high CO2\, such as inside a growing colony\, but transcription is induced in response to low CO2 levels\, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCE103" EXACT []
synonym: "NCE3" EXACT []
synonym: "carbonate dehydratase NCE103" EXACT []

[Term]
id: sgd:S000004982
name: YNL037C
def: "Subunit of mitochondrial NAD\(+\)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDH1" EXACT []
synonym: "isocitrate dehydrogenase (NAD(+)) IDH1" EXACT []

[Term]
id: sgd:S000004983
name: YNL038W
def: "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol \(GPI\) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPI15" EXACT []

[Term]
id: sgd:S000004984
name: YNL039W
def: "Essential subunit of RNA polymerase III transcription factor \(TFIIIB\); TFIIIB is involved in transcription of genes encoding tRNAs\, 5S rRNA\, U6 snRNA\, and other small RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B\"" EXACT []
synonym: "BDP1" EXACT []
synonym: "TFC5" EXACT []
synonym: "TFC7" EXACT []
synonym: "TFIIIB90" EXACT []
synonym: "transcription factor TFIIIB subunit BDP1" EXACT []

[Term]
id: sgd:S000004985
name: YNL040W
def: "Putative protein of unknown function; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative alanine--tRNA ligase" EXACT []

[Term]
id: sgd:S000004986
name: YNL041C
def: "Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COD2" EXACT []
synonym: "COG6" EXACT []
synonym: "SEC37" EXACT []

[Term]
id: sgd:S000004987
name: YNL042W
def: "Protein of unknown function; potential Cdc28p substrate; overproduction confers resistance to methylmercury" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOP3" EXACT []

[Term]
id: sgd:S000004988
name: YNL043C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004989
name: YNL044W
def: "Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIP3" EXACT []

[Term]
id: sgd:S000004990
name: YNL045W
def: "Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAP2" EXACT []

[Term]
id: sgd:S000004991
name: YNL046W
def: "Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004992
name: YNL047C
def: "Phosphoinositide PI4\,5P\(2\) binding protein\, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog\, SLM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIT1" EXACT []
synonym: "SLM2" EXACT []

[Term]
id: sgd:S000004993
name: YNL048W
def: "Alpha-1\,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1\,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-mannosyltransferase ALG11" EXACT []
synonym: "ALG11" EXACT []
synonym: "alpha-1" EXACT []

[Term]
id: sgd:S000004994
name: YNL049C
def: "Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog\, SEC24\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COPII subunit SFB2" EXACT []
synonym: "ISS1" EXACT []
synonym: "SFB2" EXACT []

[Term]
id: sgd:S000004995
name: YNL050C
def: "Putative protein of unknown function; YNL050c is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000004996
name: YNL051W
def: "Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "API4" EXACT []
synonym: "COD4" EXACT []
synonym: "COG5" EXACT []

[Term]
id: sgd:S000004997
name: YNL052W
def: "Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb \(Cox5Bp\) is expressed during anaerobic growth; COX5A has a paralog\, COX5B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX5A" EXACT []
synonym: "cytochrome c oxidase subunit Va" EXACT []

[Term]
id: sgd:S000004998
name: YNL053W
def: "Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway\, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p; MSG5 has a paralog\, SDP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSG5" EXACT []
synonym: "tyrosine/serine/threonine protein phosphatase MSG5" EXACT []

[Term]
id: sgd:S000004999
name: YNL054W
def: "Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAC7" EXACT []

[Term]
id: sgd:S000005000
name: YNL055C
def: "Mitochondrial porin \(voltage-dependent anion channel\); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glutathione pools of the intermembrane space \(IMS\) and the cytosol; interacts with Om45 and Om14 in the outer membrane; phosphorylated; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OMP2" EXACT []
synonym: "POR1" EXACT []
synonym: "VDAC" EXACT []
synonym: "YVDAC1" EXACT []
synonym: "porin POR1" EXACT []

[Term]
id: sgd:S000005001
name: YNL056W
def: "Putative protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA2" EXACT []

[Term]
id: sgd:S000005002
name: YNL057W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005003
name: YNL058C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog\, PRM5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005004
name: YNL059C
def: "Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP5" EXACT []

[Term]
id: sgd:S000005005
name: YNL061W
def: "rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA while Rcm1p methylates cytosine at position 2278; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; homolog of p120/NSUN1\, a human gene upregulated in cancer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP2" EXACT []
synonym: "YNA1" EXACT []

[Term]
id: sgd:S000005006
name: YNL062C
def: "Subunit of tRNA \(1-methyladenosine\) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs\, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD10" EXACT []
synonym: "TRM6" EXACT []

[Term]
id: sgd:S000005007
name: YNL063W
def: "S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTQ1" EXACT []

[Term]
id: sgd:S000005008
name: YNL064C
def: "Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP40" EXACT []
synonym: "MAB3" EXACT []
synonym: "MAS5" EXACT []
synonym: "YDJ1" EXACT []
synonym: "type I HSP40 co-chaperone YDJ1" EXACT []

[Term]
id: sgd:S000005009
name: YNL065W
def: "Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog\, QDR1\, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AQR1" EXACT []

[Term]
id: sgd:S000005010
name: YNL066W
def: "Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog\, SIM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCW3" EXACT []
synonym: "SUN4" EXACT []
synonym: "putative glucosidase SUN4" EXACT []

[Term]
id: sgd:S000005011
name: YNL067W
def: "Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog\, RPL9A\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L6" EXACT []
synonym: "L8B" EXACT []
synonym: "L9B" EXACT []
synonym: "RPL9B" EXACT []
synonym: "YL11" EXACT []
synonym: "ribosomal 60S subunit protein L9B" EXACT []
synonym: "rp24" EXACT []

[Term]
id: sgd:S000005012
name: YNL068C
def: "Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; facilitates clustering and activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; relocalizes to the cytosol in response to hypoxia; FKH2 has a paralog\, FKH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FKH2" EXACT []
synonym: "forkhead family transcription factor FKH2" EXACT []

[Term]
id: sgd:S000005013
name: YNL069C
def: "Ribosomal 60S subunit protein L16B; N-terminally acetylated\, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog\, RPL16A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L13" EXACT []
synonym: "L16B" EXACT []
synonym: "L21B" EXACT []
synonym: "RP23" EXACT []
synonym: "RPL16B" EXACT []
synonym: "YL15" EXACT []
synonym: "ribosomal 60S subunit protein L16B" EXACT []
synonym: "rp23" EXACT []

[Term]
id: sgd:S000005014
name: YNL070W
def: "Component of the TOM \(translocase of outer membrane\) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOM7" EXACT []
synonym: "TOM7" EXACT []
synonym: "YOK22" EXACT []

[Term]
id: sgd:S000005015
name: YNL071W
def: "Dihydrolipoamide acetyltransferase component \(E2\) of the PDC; the pyruvate dehydrogenase complex \(PDC\) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAT1" EXACT []
synonym: "ODP2" EXACT []
synonym: "PDA2" EXACT []
synonym: "dihydrolipoyllysine-residue acetyltransferase" EXACT []

[Term]
id: sgd:S000005016
name: YNL072W
def: "Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNH201" EXACT []
synonym: "RNH35" EXACT []
synonym: "Rnh2A" EXACT []

[Term]
id: sgd:S000005017
name: YNL073W
def: "Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA\(Lys\) into mitochondria and for aminoacylation of mitochondrially encoded tRNA\(Lys\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSK1" EXACT []
synonym: "lysine--tRNA ligase MSK1" EXACT []

[Term]
id: sgd:S000005018
name: YNL074C
def: "Serine-rich protein of unknown function; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog\, VHS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLF3" EXACT []
synonym: "YMK1" EXACT []

[Term]
id: sgd:S000005019
name: YNL075W
def: "Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma\(70\)-like motif and associate with RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP4" EXACT []

[Term]
id: sgd:S000005020
name: YNL076W
def: "Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde \(RTG\) mitochondria-to-nucleus signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYS80" EXACT []
synonym: "MKS1" EXACT []

[Term]
id: sgd:S000005021
name: YNL077W
def: "Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the \[Psi+\] prion; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APJ1" EXACT []

[Term]
id: sgd:S000005022
name: YNL078W
def: "Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JIP1" EXACT []
synonym: "NIS1" EXACT []

[Term]
id: sgd:S000005023
name: YNL079C
def: "Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments\, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog\, TPM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPM1" EXACT []
synonym: "tropomyosin TPM1" EXACT []

[Term]
id: sgd:S000005024
name: YNL080C
def: "Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EOS1" EXACT []

[Term]
id: sgd:S000005025
name: YNL081C
def: "Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWS2" EXACT []
synonym: "putative mitochondrial 37S ribosomal protein SWS2" EXACT []

[Term]
id: sgd:S000005026
name: YNL082W
def: "ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain\, similar to E. coli MutL" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMS1" EXACT []

[Term]
id: sgd:S000005027
name: YNL083W
def: "ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers\, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Ca(2+)-binding ATP:ADP antiporter SAL1" EXACT []
synonym: "SAL1" EXACT []

[Term]
id: sgd:S000005028
name: YNL084C
def: "EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END3" EXACT []

[Term]
id: sgd:S000005029
name: YNL085W
def: "Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability\, drug resistance\, and more; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MKT1" EXACT []

[Term]
id: sgd:S000005030
name: YNL086W
def: "Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein \(GFP\)-fusion protein localizes to endosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLS1" EXACT []
synonym: "SNN1" EXACT []

[Term]
id: sgd:S000005031
name: YNL087W
def: "ER protein involved in ER-plasma membrane tethering; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to plasma membrane \(PM\) and regulate PM phosphatidylinositol-4-phosphate \(PI4P\) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog\, TCB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCB2" EXACT []

[Term]
id: sgd:S000005032
name: YNL088W
def: "Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone \(RSZ\) breakage following Mec1p inactivation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA topoisomerase 2" EXACT []
synonym: "TOP2" EXACT []
synonym: "TOR3" EXACT []
synonym: "TRF3" EXACT []

[Term]
id: sgd:S000005033
name: YNL089C
def: "Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005034
name: YNL090W
def: "Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHO2" EXACT []
synonym: "Rho family GTPase RHO2" EXACT []

[Term]
id: sgd:S000005035
name: YNL091W
def: "Protein of unknown function; mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NST1" EXACT []

[Term]
id: sgd:S000005036
name: YNL092W
def: "S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005037
name: YNL093W
def: "Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog\, VPS21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT53" EXACT []
synonym: "YPT53" EXACT []

[Term]
id: sgd:S000005038
name: YNL094W
def: "Phosphatidate phosphatase\, converts phosphatidate to diacylglycerol; App1p\, Pah1p\, Dpp1p\, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APP1" EXACT []
synonym: "phosphatidate phosphatase APP1" EXACT []

[Term]
id: sgd:S000005039
name: YNL095C
def: "Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog\, ECM3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005040
name: YNL096C
def: "Protein component of the small \(40S\) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7\, no bacterial homolog; RPS7B has a paralog\, RPS7A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS7B" EXACT []
synonym: "S7B" EXACT []
synonym: "S7e" EXACT []
synonym: "ribosomal 40S subunit protein S7B" EXACT []
synonym: "rp30" EXACT []

[Term]
id: sgd:S000005041
name: YNL097C
def: "Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts \(CUTs\); C-terminus has similarity to human candidate tumor suppressor p33\(ING1\) and its isoform ING3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO23" EXACT []

[Term]
id: sgd:S000005042
name: YNL098C
def: "GTP-binding protein; regulates nitrogen starvation response\, sporulation\, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog\, RAS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTN5" EXACT []
synonym: "CYR3" EXACT []
synonym: "GLC5" EXACT []
synonym: "RAS2" EXACT []
synonym: "Ras family GTPase RAS2" EXACT []
synonym: "TSL7" EXACT []

[Term]
id: sgd:S000005043
name: YNL099C
def: "Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OCA1" EXACT []
synonym: "putative tyrosine protein phosphatase OCA1" EXACT []

[Term]
id: sgd:S000005044
name: YNL100W
def: "Component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM37" EXACT []
synonym: "MCS27" EXACT []
synonym: "MIC27" EXACT []

[Term]
id: sgd:S000005045
name: YNL101W
def: "Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes \(AVT1-7\) related to vesicular GABA-glycine transporters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVT4" EXACT []

[Term]
id: sgd:S000005046
name: YNL102W
def: "Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC17" EXACT []
synonym: "CRT5" EXACT []
synonym: "DNA-directed DNA polymerase alpha catalytic subunit POL1" EXACT []
synonym: "HPR3" EXACT []
synonym: "POL1" EXACT []

[Term]
id: sgd:S000005047
name: YNL103W
def: "Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p\, Met28p\, Met31p and Met32p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; can be ubiquitinated by ubiquitin ligase SCF-Met30p\, is either degraded or maintained in an inactive state; regulates degradation of its own DNA-binding cofactors by targeting them to SCF-Met30p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET4" EXACT []

[Term]
id: sgd:S000005048
name: YNL104C
def: "Alpha-isopropylmalate synthase \(2-isopropylmalate synthase\); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog\, LEU9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-isopropylmalate synthase LEU4" EXACT []
synonym: "LEU4" EXACT []

[Term]
id: sgd:S000005049
name: YNL105W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT16" EXACT []

[Term]
id: sgd:S000005050
name: YNL106C
def: "Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates \(PtdInsPs\, PIPs\) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog\, INP53\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP52" EXACT []
synonym: "SJL2" EXACT []
synonym: "phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52" EXACT []

[Term]
id: sgd:S000005051
name: YNL107W
def: "Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAF9" EXACT []

[Term]
id: sgd:S000005052
name: YNL108C
def: "Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog\, TFC7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUF" EXACT []

[Term]
id: sgd:S000005053
name: YNL109W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005054
name: YNL110C
def: "Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP15" EXACT []

[Term]
id: sgd:S000005055
name: YNL111C
def: "Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYB5" EXACT []

[Term]
id: sgd:S000005056
name: YNL112W
def: "ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; interacts with YRA1; required for the assembly of Yra1p\, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP2" EXACT []
synonym: "DEAD-box ATP-dependent RNA helicase DBP2" EXACT []

[Term]
id: sgd:S000005057
name: YNL113W
def: "RNA polymerase subunit AC19; common to RNA polymerases I and III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AC19" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPC19" EXACT []
synonym: "RPC19" EXACT []

[Term]
id: sgd:S000005058
name: YNL114C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W\, an RNA polymerase subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005059
name: YNL115C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YNL115C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005060
name: YNL116W
def: "Ubiquitin-protein ligase \(E3\); controls septin dynamics and spindle position checkpoint \(SPOC\) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p\, as well as abundance\, localization\, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8\, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog\, DMA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHF2" EXACT []
synonym: "DMA2" EXACT []
synonym: "ubiquitin-conjugating protein DMA2" EXACT []

[Term]
id: sgd:S000005061
name: YNL117W
def: "Malate synthase\, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid\, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLS1" EXACT []
synonym: "malate synthase MLS1" EXACT []

[Term]
id: sgd:S000005062
name: YNL118C
def: "Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; also enters the nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCP2" EXACT []
synonym: "PSU1" EXACT []
synonym: "decapping enzyme complex catalytic subunit DCP1" EXACT []

[Term]
id: sgd:S000005063
name: YNL119W
def: "Protein required for uridine thiolation of Lys\(UUU\) and Glu\(UUC\) tRNAs; required for the thiolation of uridine at the wobble position of Lys\(UUU\) and Glu\(UUC\) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCS2" EXACT []
synonym: "TUC2" EXACT []

[Term]
id: sgd:S000005064
name: YNL120C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae\, but likely due to effects on the overlapping gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005065
name: YNL121C
def: "Component of the TOM \(translocase of outer membrane\) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog\, TOM71\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS70" EXACT []
synonym: "MOM72" EXACT []
synonym: "OMP1" EXACT []
synonym: "TOM70" EXACT []
synonym: "protein channel TOM70" EXACT []

[Term]
id: sgd:S000005066
name: YNL122C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YNL122C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005067
name: YNL123W
def: "Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NMA111" EXACT []
synonym: "YNM3" EXACT []

[Term]
id: sgd:S000005068
name: YNL124W
def: "RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAF1" EXACT []

[Term]
id: sgd:S000005069
name: YNL125C
def: "Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate\, pyruvate or acetate across the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESBP6" EXACT []
synonym: "MCH3" EXACT []

[Term]
id: sgd:S000005070
name: YNL126W
def: "Component of the microtubule-nucleating Tub4p \(gamma-tubulin\) complex; interacts with Spc110p at the spindle pole body \(SPB\) inner plaque and with Spc72p at the SPB outer plaque" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPC98" EXACT []

[Term]
id: sgd:S000005071
name: YNL127W
def: "Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p\, Far7p\, Far8p\, Far9p\, Far10p and with the phosphatases Pph21p\, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAR11" EXACT []

[Term]
id: sgd:S000005072
name: YNL128W
def: "PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TEP1" EXACT []

[Term]
id: sgd:S000005073
name: YNL129W
def: "Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRK1" EXACT []
synonym: "ribosylnicotinamide kinase" EXACT []

[Term]
id: sgd:S000005074
name: YNL130C
def: "Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog\, EPT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPT1" EXACT []
synonym: "diacylglycerol cholinephosphotransferase" EXACT []

[Term]
id: sgd:S000005075
name: YNL131W
def: "Component of the TOM \(Translocase of Outer Membrane\) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as a receptor for precursor proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS17" EXACT []
synonym: "MAS22" EXACT []
synonym: "MOM22" EXACT []
synonym: "TOM22" EXACT []

[Term]
id: sgd:S000005076
name: YNL132W
def: "Protein required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; NAT10\, the human homolog\, implicated in several types of cancer and premature aging." []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE33" EXACT []
synonym: "RRA1" EXACT []

[Term]
id: sgd:S000005077
name: YNL133C
def: "Protein of unknown function; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV6" EXACT []

[Term]
id: sgd:S000005078
name: YNL134C
def: "Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005079
name: YNL135C
def: "Peptidyl-prolyl cis-trans isomerase \(PPIase\); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FKB1" EXACT []
synonym: "FPR1" EXACT []
synonym: "RBP1" EXACT []
synonym: "peptidylprolyl isomerase FPR1" EXACT []

[Term]
id: sgd:S000005080
name: YNL136W
def: "Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF7" EXACT []

[Term]
id: sgd:S000005081
name: YNL137C
def: "Mitochondrial ribosomal component of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNA6" EXACT []
synonym: "NAM9" EXACT []
synonym: "mitochondrial 37S ribosomal protein NAM9" EXACT []

[Term]
id: sgd:S000005082
name: YNL138W
def: "CAP \(cyclase-associated protein\); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus\, in physically and genetically separate activity\, binds and recycles cofilin bound\, ADP-actin monomers\, facilitating regulation of actin dynamics and cell morphogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAP" EXACT []
synonym: "SRV2" EXACT []

[Term]
id: sgd:S000005083
name: YNL139C
def: "Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB5" EXACT []
synonym: "RLR1" EXACT []
synonym: "THO2" EXACT []
synonym: "ZRG13" EXACT []

[Term]
id: sgd:S000005084
name: YNL140C
def: "Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005085
name: YNL141W
def: "Adenine deaminase \(adenine aminohydrolase\); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAH1" EXACT []
synonym: "adenine deaminase" EXACT []

[Term]
id: sgd:S000005086
name: YNL142W
def: "Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium \(NH4+\); expression is under the nitrogen catabolite repression regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEP2" EXACT []
synonym: "ammonium permease MEP2" EXACT []

[Term]
id: sgd:S000005087
name: YNL143C
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005088
name: YNL144C
def: "Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; YNL144C has a paralog\, YHR131C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005089
name: YNL145W
def: "Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification\, N-terminal proteolysis\, and export; also encoded by MFA1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFA2" EXACT []

[Term]
id: sgd:S000005090
name: YNL146W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005091
name: YNL147W
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM7" EXACT []
synonym: "Sm-like protein LSM7" EXACT []

[Term]
id: sgd:S000005092
name: YNL148C
def: "Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALF1" EXACT []

[Term]
id: sgd:S000005093
name: YNL149C
def: "Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGA2" EXACT []

[Term]
id: sgd:S000005094
name: YNL150W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C\, an uncharacterized gene with a proposed role in protein trafficking" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005095
name: YNL151C
def: "RNA polymerase III subunit C31" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACP2" EXACT []
synonym: "C31" EXACT []
synonym: "RPC31" EXACT []
synonym: "RPC8" EXACT []

[Term]
id: sgd:S000005096
name: YNL152W
def: "Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain\, a membrane targeting module\, is required for function; activates chitin synthase activity of Chs2p during cytokinesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INN1" EXACT []

[Term]
id: sgd:S000005097
name: YNL153C
def: "Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIM3" EXACT []
synonym: "PFD4" EXACT []

[Term]
id: sgd:S000005098
name: YNL154C
def: "Palmitoylated plasma membrane-bound casein kinase I \(CK1\) isoform; shares redundant functions with Yck1p in morphogenesis\, proper septin assembly\, endocytic trafficking\, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen\, causing glucose repression of respiratory metabolism; YCK2 has a paralog\, YCK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCK2" EXACT []
synonym: "serine/threonine protein kinase YCK2" EXACT []

[Term]
id: sgd:S000005099
name: YNL155W
def: "Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein\, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein\, with DHHC and ubiquitin-like domains \(UBL\); ortholog of ZFAND1\, a human gene linked to cancer; protein abundance increases under DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUZ1" EXACT []

[Term]
id: sgd:S000005100
name: YNL156C
def: "Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p\, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog\, NSG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSG2" EXACT []

[Term]
id: sgd:S000005101
name: YNL157W
def: "Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog\, IGO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IGO1" EXACT []

[Term]
id: sgd:S000005102
name: YNL158W
def: "Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGA1" EXACT []

[Term]
id: sgd:S000005103
name: YNL159C
def: "Subunit of the nuclear inner membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by targeting latent unprocessed forms of Stp1p and Stp2p and maintains the repressed state of gene expression in the absence of inducing amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASI2" EXACT []

[Term]
id: sgd:S000005104
name: YNL160W
def: "Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; YGP1 has a paralog\, SPS100\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YGP1" EXACT []

[Term]
id: sgd:S000005105
name: YNL161W
def: "Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis\, polarized growth\, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBK1" EXACT []
synonym: "serine/threonine protein kinase CBK1" EXACT []

[Term]
id: sgd:S000005106
name: YNL162W
def: "Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A\, no bacterial homolog; RPL42A has a paralog\, RPL42B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L41A" EXACT []
synonym: "L42A" EXACT []
synonym: "L44e" EXACT []
synonym: "RPL42A" EXACT []
synonym: "YL27" EXACT []
synonym: "ribosomal 60S subunit protein L42A" EXACT []

[Term]
id: sgd:S000005107
name: YNL163C
def: "Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p\, a guanine nucleotide exchange factor \(GEF\)\, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFL1" EXACT []
synonym: "GTPase RIA1" EXACT []
synonym: "RIA1" EXACT []

[Term]
id: sgd:S000005108
name: YNL164C
def: "Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IBD2" EXACT []

[Term]
id: sgd:S000005109
name: YNL165W
def: "Putative protein of unknown function; YNL165W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005110
name: YNL166C
def: "Protein involved in organization of septins at the mother-bud neck; may interact directly with the Cdc11p septin\, localizes to bud neck in a septin-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNI5" EXACT []

[Term]
id: sgd:S000005111
name: YNL167C
def: "Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACR1" EXACT []
synonym: "SKO1" EXACT []

[Term]
id: sgd:S000005112
name: YNL168C
def: "Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP41" EXACT []

[Term]
id: sgd:S000005113
name: YNL169C
def: "Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSD1" EXACT []
synonym: "phosphatidylserine decarboxylase 1" EXACT []

[Term]
id: sgd:S000005114
name: YNL170W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005115
name: YNL171C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005116
name: YNL172W
def: "Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; component of the platform domain of the APC/C\, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC1" EXACT []
synonym: "anaphase promoting complex subunit 1" EXACT []

[Term]
id: sgd:S000005117
name: YNL173C
def: "Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog\, CRP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDG1" EXACT []

[Term]
id: sgd:S000005118
name: YNL174W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005119
name: YNL175C
def: "Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif \(RRM\); relative distribution to the nucleolus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP13" EXACT []

[Term]
id: sgd:S000005120
name: YNL176C
def: "Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog\, YDL211C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA7" EXACT []

[Term]
id: sgd:S000005121
name: YNL177C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL22" EXACT []
synonym: "YmL22" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL22" EXACT []

[Term]
id: sgd:S000005122
name: YNL178W
def: "Protein component of the small \(40S\) ribosomal subunit; has apurinic/apyrimidinic \(AP\) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS3" EXACT []
synonym: "S3" EXACT []
synonym: "SUF14" EXACT []
synonym: "YS3" EXACT []
synonym: "ribosomal 40S subunit protein S3" EXACT []
synonym: "rp13" EXACT []

[Term]
id: sgd:S000005123
name: YNL179C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF6" EXACT []

[Term]
id: sgd:S000005124
name: YNL180C
def: "Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C \(Pkc1p\)-dependent signal transduction pathway that controls cell integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHO5" EXACT []
synonym: "Rho family GTPase RHO5" EXACT []
synonym: "YNS0" EXACT []

[Term]
id: sgd:S000005125
name: YNL181W
def: "Putative oxidoreductase; required for cell viability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005126
name: YNL182C
def: "Component of the Rix1 complex and pre-replicative complexes \(pre-RCs\); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p\, Ipi1p\, and Ipi3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPI3" EXACT []

[Term]
id: sgd:S000005127
name: YNL183C
def: "Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p\, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog\, PRR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPR1" EXACT []
synonym: "serine/threonine protein kinase NPR1" EXACT []

[Term]
id: sgd:S000005128
name: YNL184C
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005129
name: YNL185C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL19" EXACT []
synonym: "YmL19" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL19" EXACT []

[Term]
id: sgd:S000005130
name: YNL186W
def: "Ubiquitin-specific protease\, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis; stabilizes Rpa190p\, the largest subunit of RNAP I\, by mediating its deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; localized to the nucleolus; human USP36 is a functional analog of Ubp10p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOT4" EXACT []
synonym: "UBP10" EXACT []

[Term]
id: sgd:S000005131
name: YNL187W
def: "Protein involved in mRNA splicing; contains a consensus nuclear export signal \(NES\) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWT21" EXACT []

[Term]
id: sgd:S000005132
name: YNL188W
def: "Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in spindle pole body duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAR1" EXACT []

[Term]
id: sgd:S000005133
name: YNL189W
def: "Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins\, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP60" EXACT []
synonym: "SCM1" EXACT []
synonym: "SRP1" EXACT []
synonym: "karyopherin alpha" EXACT []

[Term]
id: sgd:S000005134
name: YNL190W
def: "Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005135
name: YNL191W
def: "Component of glutamine amidotransferase \(GATase II\); forms a complex with Dug2p to degrade glutathione \(GSH\) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase \(Ecm38p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUG3" EXACT []
synonym: "glutamine amidotransferase subunit DUG3" EXACT []

[Term]
id: sgd:S000005136
name: YNL192W
def: "Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine \(GlcNAc\) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHS1" EXACT []
synonym: "USA4" EXACT []
synonym: "chitin synthase CHS1" EXACT []

[Term]
id: sgd:S000005137
name: YNL193W
def: "Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005138
name: YNL194C
def: "Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs \(membrane compartment occupied by Can1\) in the presence of glycerol and oleate; YNL194C has a paralog\, FMP45\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005139
name: YNL195C
def: "Protein of unknown function; shares a promoter with YNL194C; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog\, HBT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005140
name: YNL196C
def: "Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLZ1" EXACT []

[Term]
id: sgd:S000005141
name: YNL197C
def: "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; regulates genes involved in the cell cycle\, sister chromatid cohesion\, and stress response; acts as a cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; Tpk1p \(PKA\) mediated phosphorylation \(S568\) inhibits Whi3p function\, decreasing its interaction with CLN3 mRNA; regulates ploidy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WHI3" EXACT []
synonym: "mRNA-binding protein WHI3" EXACT []

[Term]
id: sgd:S000005142
name: YNL198C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005143
name: YNL199C
def: "Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCR2" EXACT []

[Term]
id: sgd:S000005144
name: YNL200C
def: "NADHX epimerase; catalyzes isomerization of \(R\)- and \(S\)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes\, prokaryotes and archaea; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NADHX epimerase" EXACT []

[Term]
id: sgd:S000005145
name: YNL201C
def: "Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex\, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint\, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining \(NHEJ\) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSY2" EXACT []

[Term]
id: sgd:S000005146
name: YNL202W
def: "Peroxisomal 2\,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS19" EXACT []
synonym: "SPX19" EXACT []

[Term]
id: sgd:S000005147
name: YNL203C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005148
name: YNL204C
def: "Protein of unknown function\, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog\, GCS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS18" EXACT []
synonym: "SPX18" EXACT []

[Term]
id: sgd:S000005149
name: YNL205C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005150
name: YNL206C
def: "Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 \(CAF-1\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTT106" EXACT []

[Term]
id: sgd:S000005151
name: YNL207W
def: "Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIO2" EXACT []
synonym: "protein kinase RIO2" EXACT []

[Term]
id: sgd:S000005152
name: YNL208W
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; authentic\, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005153
name: YNL209W
def: "Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog\, SSB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp70 family ATPase SSB2" EXACT []
synonym: "SSB2" EXACT []
synonym: "YG103" EXACT []

[Term]
id: sgd:S000005154
name: YNL210W
def: "mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs\: REC107\, HFM1\, AMA1 and SPO22" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MER1" EXACT []

[Term]
id: sgd:S000005155
name: YNL211C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YNL211C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005156
name: YNL212W
def: "Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1\,6-bisphosphatase \(FBPase\); null mutants exhibit normal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VID27" EXACT []

[Term]
id: sgd:S000005157
name: YNL213C
def: "Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRG9" EXACT []

[Term]
id: sgd:S000005158
name: YNL214W
def: "Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS9" EXACT []
synonym: "PEX17" EXACT []

[Term]
id: sgd:S000005159
name: YNL215W
def: "Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES2" EXACT []

[Term]
id: sgd:S000005160
name: YNL216W
def: "Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation and repression\, chromatin silencing\, and telomere length maintenance; relocalizes to the cytosol in response to hypoxia; conserved protein with an N-terminal BRCT domain\, a central region with homology to the Myb DNA binding domain\, and a C-terminal Rap1-specific protein-interaction domain \(RCT domain\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-binding transcription factor RAP1" EXACT []
synonym: "GRF1" EXACT []
synonym: "RAP1" EXACT []
synonym: "TBA1" EXACT []
synonym: "TUF1" EXACT []

[Term]
id: sgd:S000005161
name: YNL217W
def: "Putative protein of unknown function; weak sequence similarity to bis \(5'-nucleotidyl\)-tetraphosphatases; \(GFP\)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative serine/threonine-protein phosphatase" EXACT []

[Term]
id: sgd:S000005162
name: YNL218W
def: "Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein \(WHIP\); forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGS1" EXACT []
synonym: "ssDNA-dependent ATPase MGS1" EXACT []

[Term]
id: sgd:S000005163
name: YNL219C
def: "Mannosyltransferase\, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-mannosyltransferase" EXACT []
synonym: "ALG9" EXACT []
synonym: "dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000005164
name: YNL220W
def: "Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating \(ARS\) core sequence" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE12" EXACT []
synonym: "BRA9" EXACT []
synonym: "adenylosuccinate synthase" EXACT []

[Term]
id: sgd:S000005165
name: YNL221C
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP1" EXACT []

[Term]
id: sgd:S000005166
name: YNL222W
def: "Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSU72" EXACT []

[Term]
id: sgd:S000005167
name: YNL223W
def: "Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG4" EXACT []
synonym: "ATG4" EXACT []
synonym: "AUT2" EXACT []

[Term]
id: sgd:S000005168
name: YNL224C
def: "Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFA1" EXACT []
synonym: "SQS1" EXACT []

[Term]
id: sgd:S000005169
name: YNL225C
def: "Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog\, ADY3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNM67" EXACT []

[Term]
id: sgd:S000005170
name: YNL226W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005171
name: YNL227C
def: "Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JJJ1" EXACT []

[Term]
id: sgd:S000005172
name: YNL228W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005173
name: YNL229C
def: "Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates \[URE3\] prion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URE2" EXACT []
synonym: "[URE3]" EXACT []

[Term]
id: sgd:S000005174
name: YNL230C
def: "Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs \(ECS\) ligase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELA1" EXACT []
synonym: "elongin A" EXACT []

[Term]
id: sgd:S000005175
name: YNL231C
def: "Phosphatidylinositol transfer protein \(PITP\); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids\, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDR16" EXACT []
synonym: "SFH3" EXACT []

[Term]
id: sgd:S000005176
name: YNL232W
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p \(EXOSC1\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSL4" EXACT []
synonym: "SKI4" EXACT []

[Term]
id: sgd:S000005177
name: YNL233W
def: "Targeting subunit for Glc7p protein phosphatase; localized to the bud neck\, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNI4" EXACT []

[Term]
id: sgd:S000005178
name: YNL234W
def: "Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005179
name: YNL235C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W\, a subunit of the mediator complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005180
name: YNL236W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEL2" EXACT []
synonym: "GAL22" EXACT []
synonym: "MED16" EXACT []
synonym: "RYE1" EXACT []
synonym: "SDI3" EXACT []
synonym: "SIN4" EXACT []
synonym: "SSF5" EXACT []
synonym: "SSN4" EXACT []
synonym: "SSX3" EXACT []
synonym: "TSF3" EXACT []

[Term]
id: sgd:S000005181
name: YNL237W
def: "Probable type-III integral membrane protein of unknown function; has regions of similarity to mitochondrial electron transport proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YTP1" EXACT []

[Term]
id: sgd:S000005182
name: YNL238W
def: "Kexin\, a subtilisin-like protease \(proprotein convertase\); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEX2" EXACT []
synonym: "QDS1" EXACT []
synonym: "SRB1" EXACT []
synonym: "VMA45" EXACT []
synonym: "kexin KEX2" EXACT []
synonym: "yscF" EXACT []

[Term]
id: sgd:S000005183
name: YNL239W
def: "Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BLH1" EXACT []
synonym: "GAL6" EXACT []
synonym: "LAP3" EXACT []
synonym: "YCP1" EXACT []

[Term]
id: sgd:S000005184
name: YNL240C
def: "Subunit of the cytosolic iron-sulfur \(FeS\) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAR1" EXACT []

[Term]
id: sgd:S000005185
name: YNL241C
def: "Glucose-6-phosphate dehydrogenase \(G6PD\); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET19" EXACT []
synonym: "POS10" EXACT []
synonym: "ZWF1" EXACT []
synonym: "glucose-6-phosphate dehydrogenase" EXACT []

[Term]
id: sgd:S000005186
name: YNL242W
def: "Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting \(Cvt\) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG2" EXACT []
synonym: "ATG2" EXACT []
synonym: "AUT8" EXACT []
synonym: "SPO72" EXACT []

[Term]
id: sgd:S000005187
name: YNL243W
def: "Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "END4" EXACT []
synonym: "MOP2" EXACT []
synonym: "SLA2" EXACT []

[Term]
id: sgd:S000005188
name: YNL244C
def: "Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOF2" EXACT []
synonym: "RFR1" EXACT []
synonym: "SUI1" EXACT []
synonym: "translation initiation factor eIF1" EXACT []

[Term]
id: sgd:S000005189
name: YNL245C
def: "Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC25" EXACT []

[Term]
id: sgd:S000005190
name: YNL246W
def: "NAP family histone chaperone; binds to histones and Rtt109p\, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS75" EXACT []

[Term]
id: sgd:S000005191
name: YNL247W
def: "Cysteinyl-tRNA synthetase; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "cysteine--tRNA ligase" EXACT []

[Term]
id: sgd:S000005192
name: YNL248C
def: "RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A49" EXACT []
synonym: "DNA-directed RNA polymerase I subunit RPA49" EXACT []
synonym: "RPA49" EXACT []

[Term]
id: sgd:S000005193
name: YNL249C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPA43" EXACT []

[Term]
id: sgd:S000005194
name: YNL250W
def: "Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells\, initiation of meiotic DSBs\, telomere maintenance\, and nonhomologous end joining; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRX complex DNA-binding subunit" EXACT []
synonym: "RAD50" EXACT []

[Term]
id: sgd:S000005195
name: YNL251C
def: "RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs\, snRNAs\, snoRNAs\, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRD1" EXACT []
synonym: "Nrd1 complex RNA-binding subunit" EXACT []

[Term]
id: sgd:S000005196
name: YNL252C
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL17" EXACT []
synonym: "MRPL30" EXACT []
synonym: "YmL17" EXACT []
synonym: "YmL30" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL17/YmL30" EXACT []

[Term]
id: sgd:S000005197
name: YNL253W
def: "Protein involved in mRNA export; component of the transcription export \(TREX\) complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TEX1" EXACT []

[Term]
id: sgd:S000005198
name: YNL254C
def: "Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTC4" EXACT []

[Term]
id: sgd:S000005199
name: YNL255C
def: "Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies \(P bodies\) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP\, a gene involved in myotonic dystrophy type 2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIS2" EXACT []

[Term]
id: sgd:S000005200
name: YNL256W
def: "Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase\, dihydro-6-hydroxymethylpterin pyrophosphokinase\, and dihydroneopterin aldolase activities" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FOL1" EXACT []
synonym: "trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1" EXACT []

[Term]
id: sgd:S000005201
name: YNL257C
def: "Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog\, YSP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIP3" EXACT []

[Term]
id: sgd:S000005202
name: YNL258C
def: "Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSL1" EXACT []
synonym: "RNS1" EXACT []

[Term]
id: sgd:S000005203
name: YNL259C
def: "Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p\, which is a multicopper oxidase required for high-affinity iron uptake" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATX1" EXACT []
synonym: "copper metallochaperone ATX1" EXACT []

[Term]
id: sgd:S000005204
name: YNL260C
def: "Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1\, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard \(aerobic\) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTO1" EXACT []

[Term]
id: sgd:S000005205
name: YNL261W
def: "Subunit of the origin recognition complex \(ORC\); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC5" EXACT []
synonym: "origin recognition complex subunit 5" EXACT []

[Term]
id: sgd:S000005206
name: YNL262W
def: "Catalytic subunit of DNA polymerase \(II\) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA polymerase epsilon catalytic subunit" EXACT []
synonym: "DUN2" EXACT []
synonym: "POL2" EXACT []

[Term]
id: sgd:S000005207
name: YNL263C
def: "Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi\, the ER\, and COPII vesicles; homolog of human YIPF3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIF1" EXACT []

[Term]
id: sgd:S000005208
name: YNL264C
def: "Phosphatidylinositol transfer protein \(PITP\); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISS1" EXACT []
synonym: "PDR17" EXACT []
synonym: "SFH4" EXACT []

[Term]
id: sgd:S000005209
name: YNL265C
def: "Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IST1" EXACT []

[Term]
id: sgd:S000005210
name: YNL266W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005211
name: YNL267W
def: "Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4\,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "1-phosphatidylinositol 4-kinase" EXACT []
synonym: "PIK1" EXACT []
synonym: "PIK120" EXACT []
synonym: "PIK41" EXACT []

[Term]
id: sgd:S000005212
name: YNL268W
def: "Lysine permease; one of three amino acid permeases \(Alp1p\, Can1p\, Lyp1p\) responsible for uptake of cationic amino acids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LYP1" EXACT []
synonym: "lysine permease" EXACT []

[Term]
id: sgd:S000005213
name: YNL269W
def: "Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC4" EXACT []

[Term]
id: sgd:S000005214
name: YNL270C
def: "Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog\, CAN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALP1" EXACT []
synonym: "APL1" EXACT []
synonym: "arginine permease ALP1" EXACT []

[Term]
id: sgd:S000005215
name: YNL271C
def: "Formin; polarisome component; nucleates the formation of linear actin filaments\, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables\, functionally redundant with BNR1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BNI1" EXACT []
synonym: "PPF3" EXACT []
synonym: "SHE5" EXACT []
synonym: "formin BNI1" EXACT []

[Term]
id: sgd:S000005216
name: YNL272C
def: "Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst\, via exocyst subunit Sec15p\, on secretory vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC2" EXACT []
synonym: "guanine nucleotide exchange factor SEC2" EXACT []

[Term]
id: sgd:S000005217
name: YNL273W
def: "Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage\, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOF1" EXACT []

[Term]
id: sgd:S000005218
name: YNL274C
def: "Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GOR1" EXACT []

[Term]
id: sgd:S000005219
name: YNL275W
def: "Boron efflux transporter of the plasma membrane; binds HCO3-\, I-\, Br-\, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOR1" EXACT []

[Term]
id: sgd:S000005220
name: YNL276C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005221
name: YNL277W
def: "L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET2" EXACT []
synonym: "homoserine O-acetyltransferase" EXACT []

[Term]
id: sgd:S000005222
name: YNL278W
def: "Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation\, elongation\, and degradation; CAF120 has a paralog\, SKG3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF120" EXACT []

[Term]
id: sgd:S000005223
name: YNL279W
def: "Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM1" EXACT []
synonym: "pheromone-regulated protein PRM1" EXACT []

[Term]
id: sgd:S000005224
name: YNL280C
def: "C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol \(ergosta-8\,14 dienol\)\, and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG24" EXACT []
synonym: "delta(14)-sterol reductase" EXACT []

[Term]
id: sgd:S000005225
name: YNL281W
def: "Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCH1" EXACT []

[Term]
id: sgd:S000005226
name: YNL282W
def: "Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA\, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POP3" EXACT []

[Term]
id: sgd:S000005227
name: YNL283C
def: "Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog\, WSC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STA3" EXACT []
synonym: "WSC2" EXACT []

[Term]
id: sgd:S000005228
name: YNL284C
def: "Mitochondrial ribosomal protein of the large subunit; appears as two protein spots \(YmL10 and YmL18\) on two-dimensional SDS gels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL10" EXACT []
synonym: "MRPL18" EXACT []
synonym: "YmL10" EXACT []
synonym: "YmL18" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL10/YmL18" EXACT []

[Term]
id: sgd:S000005229
name: YNL285W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005230
name: YNL286W
def: "Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs \(RRMs\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUS2" EXACT []

[Term]
id: sgd:S000005231
name: YNL287W
def: "Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC21" EXACT []

[Term]
id: sgd:S000005232
name: YNL288W
def: "Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation\, elongation\, and degradation; binds Cdc39p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF40" EXACT []
synonym: "CCR4-NOT core subunit CAF40" EXACT []

[Term]
id: sgd:S000005233
name: YNL289W
def: "Cyclin\, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1\,2-like subfamily\, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCS26" EXACT []
synonym: "PCL1" EXACT []

[Term]
id: sgd:S000005234
name: YNL290W
def: "Subunit of heteropentameric Replication factor C \(RF-C\); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen \(PCNA\) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFC3" EXACT []
synonym: "replication factor C subunit 3" EXACT []

[Term]
id: sgd:S000005235
name: YNL291C
def: "N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MID1" EXACT []

[Term]
id: sgd:S000005236
name: YNL292W
def: "Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 \(Psi55\)\, a highly conserved tRNA modification\, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 \(Gcd- phenotype\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS4" EXACT []
synonym: "pseudouridine synthase PUS4" EXACT []

[Term]
id: sgd:S000005237
name: YNL293W
def: "Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; required for proper actin organization; also localizes to plasma membrane and sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to the TBC-domain Tre2 oncogene; MSB3 has a paralog\, MSB4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP3" EXACT []
synonym: "MSB3" EXACT []

[Term]
id: sgd:S000005238
name: YNL294C
def: "pH sensor molecule\, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAL2" EXACT []
synonym: "RIM21" EXACT []

[Term]
id: sgd:S000005239
name: YNL295W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005240
name: YNL296W
def: "Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment\, but gene does not have human ortholog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005241
name: YNL297C
def: "Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MON2" EXACT []
synonym: "YSL2" EXACT []

[Term]
id: sgd:S000005242
name: YNL298W
def: "Cdc42p-activated signal transducing kinase; member of the PAK \(p21-activated kinase\) family\, along with Ste20p and Skm1p; involved in septin ring assembly\, vacuole inheritance\, cytokinesis\, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog\, SKM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLA4" EXACT []
synonym: "ERC10" EXACT []
synonym: "serine/threonine protein kinase CLA4" EXACT []

[Term]
id: sgd:S000005243
name: YNL299W
def: "Non-canonical poly\(A\) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs\, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRF5" EXACT []
synonym: "non-canonical poly(A) polymerase TRF5" EXACT []

[Term]
id: sgd:S000005244
name: YNL300W
def: "Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS6" EXACT []

[Term]
id: sgd:S000005245
name: YNL301C
def: "Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18\, no bacterial homolog; RPL18B has a paralog\, RPL18A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L18B" EXACT []
synonym: "L18e" EXACT []
synonym: "RP28B" EXACT []
synonym: "RPL18B" EXACT []
synonym: "ribosomal 60S subunit protein L18B" EXACT []
synonym: "rp28B" EXACT []

[Term]
id: sgd:S000005246
name: YNL302C
def: "Protein component of the small \(40S\) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19\, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog\, RPS19A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RP55B" EXACT []
synonym: "RPS19B" EXACT []
synonym: "S16aB" EXACT []
synonym: "S19B" EXACT []
synonym: "S19e" EXACT []
synonym: "YS16B" EXACT []
synonym: "ribosomal 40S subunit protein S19B" EXACT []
synonym: "rp55B" EXACT []

[Term]
id: sgd:S000005247
name: YNL303W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005248
name: YNL304W
def: "Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum \(ER\)\, late Golgi\, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase YPT11" EXACT []
synonym: "YPT11" EXACT []

[Term]
id: sgd:S000005249
name: YNL305C
def: "Protein involved in apoptosis; variously described as containing a BCL-2 homology \(BH3\) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BXI1" EXACT []
synonym: "YBH3" EXACT []

[Term]
id: sgd:S000005250
name: YNL306W
def: "Mitochondrial ribosomal protein of the small subunit; essential for viability\, unlike most other mitoribosomal proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS18" EXACT []
synonym: "YmS18" EXACT []
synonym: "mitochondrial 37S ribosomal protein YmS18" EXACT []

[Term]
id: sgd:S000005251
name: YNL307C
def: "Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation\, meiotic entry\, genome stability\, phosphorylation-dependent protein degradation \(Rcn1p and Cdc6p\)\, inhibition of protein kinase A\, transcriptional regulation\, inhibition of RNA pol III\, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog\, YGK3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMS1" EXACT []
synonym: "MCK1" EXACT []
synonym: "YPK1" EXACT []
synonym: "serine/threonine/tyrosine protein kinase MCK1" EXACT []

[Term]
id: sgd:S000005252
name: YNL308C
def: "Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRI1" EXACT []

[Term]
id: sgd:S000005253
name: YNL309W
def: "Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p\, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog\, YOL131W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STB1" EXACT []

[Term]
id: sgd:S000005254
name: YNL310C
def: "Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p \(mtHSP70\) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP28" EXACT []
synonym: "HEP1" EXACT []
synonym: "TIM15" EXACT []
synonym: "ZIM17" EXACT []

[Term]
id: sgd:S000005255
name: YNL311C
def: "F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKP2" EXACT []
synonym: "putative SCF ubiquitin ligase complex subunit SKP2" EXACT []

[Term]
id: sgd:S000005256
name: YNL312W
def: "Subunit of heterotrimeric Replication Protein A \(RPA\); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication\, repair\, and recombination; RPA protects against inappropriate telomere recombination\, and upon telomere uncapping\, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p\, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUF1" EXACT []
synonym: "RFA2" EXACT []
synonym: "RPA2" EXACT []
synonym: "RPA32" EXACT []

[Term]
id: sgd:S000005257
name: YNL313C
def: "Essential conserved protein with a role in cell wall integrity; contains six TPR \(tetratricopeptide repeat\) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMW1" EXACT []

[Term]
id: sgd:S000005258
name: YNL314W
def: "Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding\, a transcriptional activation\, and a coiled-coil domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAL82" EXACT []
synonym: "DURM" EXACT []

[Term]
id: sgd:S000005259
name: YNL315C
def: "Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP11" EXACT []

[Term]
id: sgd:S000005260
name: YNL316C
def: "Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate\, which is a step in the phenylalanine biosynthesis pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHA2" EXACT []
synonym: "prephenate dehydratase PHA2" EXACT []

[Term]
id: sgd:S000005261
name: YNL317W
def: "Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor \(CPF\) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFS2" EXACT []

[Term]
id: sgd:S000005262
name: YNL318C
def: "Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT14" EXACT []

[Term]
id: sgd:S000005263
name: YNL319W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005264
name: YNL320W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005265
name: YNL321W
def: "Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger \(CAX\) family; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VNX1" EXACT []

[Term]
id: sgd:S000005266
name: YNL322C
def: "Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE1" EXACT []

[Term]
id: sgd:S000005267
name: YNL323W
def: "Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase \(flippase\) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRE3" EXACT []
synonym: "LEM3" EXACT []
synonym: "ROS3" EXACT []

[Term]
id: sgd:S000005268
name: YNL324W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005269
name: YNL325C
def: "Phosphatidylinositol 3\,5-bisphosphate \(PtdIns\[3\,5\]P\) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4\, which is associated with CMT4J\, a form of Charcot-Marie-Tooth disorder" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "5-bisphosphate 5-phosphatase" EXACT []
synonym: "FIG4" EXACT []
synonym: "phosphatidylinositol-3" EXACT []

[Term]
id: sgd:S000005270
name: YNL326C
def: "Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich \(DHHC-CRD\) domain; autoacylates; required for vacuolar integrity under stress conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFA3" EXACT []

[Term]
id: sgd:S000005271
name: YNL327W
def: "Glycosylphosphatidylinositol \(GPI\)-anchored cell wall endoglucanase; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGT2" EXACT []

[Term]
id: sgd:S000005272
name: YNL328C
def: "Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDJ2" EXACT []

[Term]
id: sgd:S000005273
name: YNL329C
def: "AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase peroxin 6" EXACT []
synonym: "PAS8" EXACT []
synonym: "PEX6" EXACT []

[Term]
id: sgd:S000005274
name: YNL330C
def: "Histone deacetylase\, component of both the Rpd3S and Rpd3L complexes; regulates transcription\, silencing\, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3\(L\) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase\, Hmt1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOF6" EXACT []
synonym: "REC3" EXACT []
synonym: "RPD3" EXACT []
synonym: "SDI2" EXACT []
synonym: "SDS6" EXACT []
synonym: "histone deacetylase RPD3" EXACT []

[Term]
id: sgd:S000005275
name: YNL331C
def: "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs \(AAD3 + AAD15\, AAD6/AAD16 + AAD4\, AAD10 + AAD14\) whose two genes are more related to one another than to other members of the family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAD14" EXACT []

[Term]
id: sgd:S000005276
name: YNL332W
def: "Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5\, THI11\, THI12\, and THI13; hydroxymethylpyrimidine is also known as HMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI12" EXACT []

[Term]
id: sgd:S000005277
name: YNL333W
def: "Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift\, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNZ2" EXACT []
synonym: "pyridoxine biosynthesis protein SNZ2" EXACT []

[Term]
id: sgd:S000005278
name: YNL334C
def: "Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNO2" EXACT []

[Term]
id: sgd:S000005279
name: YNL335W
def: "Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDI3" EXACT []

[Term]
id: sgd:S000005280
name: YNL336W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS1" EXACT []

[Term]
id: sgd:S000005281
name: YNL337W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005282
name: YNL338W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC\, which is a telomeric X element core sequence on the left arm of chromosome XIV" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005283
name: YNL339C
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 6" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-6" EXACT []

[Term]
id: sgd:S000005284
name: YNR001C
def: "Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog\, CIT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIT1" EXACT []
synonym: "CS1" EXACT []
synonym: "LYS6" EXACT []
synonym: "citrate (Si)-synthase CIT1" EXACT []

[Term]
id: sgd:S000005285
name: YNR002C
def: "Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog\, ADY2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATO2" EXACT []
synonym: "FUN34" EXACT []
synonym: "putative ammonium permease ATO2" EXACT []

[Term]
id: sgd:S000005286
name: YNR003C
def: "RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C34" EXACT []
synonym: "RPC34" EXACT []

[Term]
id: sgd:S000005287
name: YNR004W
def: "Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA\, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWM2" EXACT []

[Term]
id: sgd:S000005288
name: YNR005C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005289
name: YNR006W
def: "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins\, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin \(Ubi4p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DID7" EXACT []
synonym: "ESCRT-0 subunit protein VPS27" EXACT []
synonym: "GRD11" EXACT []
synonym: "SSV17" EXACT []
synonym: "VPL23" EXACT []
synonym: "VPS27" EXACT []
synonym: "VPT27" EXACT []

[Term]
id: sgd:S000005290
name: YNR007C
def: "E2-like enzyme; involved in autophagy and the cytoplasm-to-vacuole targeting \(Cvt\) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates\, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p \(catalytic subunit of NuA4 histone acetyltransferase complex\) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG3" EXACT []
synonym: "ATG3" EXACT []
synonym: "AUT1" EXACT []

[Term]
id: sgd:S000005291
name: YNR008W
def: "Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LRO1" EXACT []
synonym: "phospholipid:diacylglycerol acyltransferase" EXACT []

[Term]
id: sgd:S000005292
name: YNR009W
def: "Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor \(MBF\) to repress transcription upon exit from G1 phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRM1" EXACT []

[Term]
id: sgd:S000005293
name: YNR010W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSE2" EXACT []
synonym: "MED9" EXACT []

[Term]
id: sgd:S000005294
name: YNR011C
def: "RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAH-box RNA-dependent ATPase PRP2" EXACT []
synonym: "PRP2" EXACT []
synonym: "RNA2" EXACT []

[Term]
id: sgd:S000005295
name: YNR012W
def: "Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway\, converting deoxycytidine into dCMP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URK1" EXACT []
synonym: "uridine kinase URK1" EXACT []

[Term]
id: sgd:S000005296
name: YNR013C
def: "Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84\, pho87\, pho89\, pho90\, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHO91" EXACT []

[Term]
id: sgd:S000005297
name: YNR014W
def: "Putative protein of unknown function; expression is cell-cycle regulated\, Azf1p-dependent\, and heat-inducible; YNR014W has a paralog\, YMR206W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005298
name: YNR015W
def: "Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p\, Smm1p\, Dus3p\, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUS2" EXACT []
synonym: "SMM1" EXACT []

[Term]
id: sgd:S000005299
name: YNR016C
def: "Acetyl-CoA carboxylase\, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog\, HFA1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABP2" EXACT []
synonym: "ACC1" EXACT []
synonym: "FAS3" EXACT []
synonym: "MTR7" EXACT []
synonym: "acetyl-CoA carboxylase ACC1" EXACT []

[Term]
id: sgd:S000005300
name: YNR017W
def: "Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p\, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAS6" EXACT []
synonym: "MIM23" EXACT []
synonym: "MPI3" EXACT []
synonym: "TIM23" EXACT []
synonym: "protein transporter TIM23" EXACT []

[Term]
id: sgd:S000005301
name: YNR018W
def: "Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p\, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM38" EXACT []
synonym: "RCF2" EXACT []

[Term]
id: sgd:S000005302
name: YNR019W
def: "Acyl-CoA\:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog\, ARE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARE2" EXACT []
synonym: "SAT1" EXACT []

[Term]
id: sgd:S000005303
name: YNR020C
def: "Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system\, and folding is assisted by Mia40p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP23" EXACT []

[Term]
id: sgd:S000005304
name: YNR021W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005305
name: YNR022C
def: "Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL50" EXACT []
synonym: "mitochondrial 54S ribosomal protein MRPL50" EXACT []

[Term]
id: sgd:S000005306
name: YNR023W
def: "73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog\, RSC6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNF12" EXACT []
synonym: "SWP73" EXACT []

[Term]
id: sgd:S000005307
name: YNR024W
def: "Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs\, and the degradation of cryptic non-coding RNAs \(ncRNA\); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPP6" EXACT []

[Term]
id: sgd:S000005308
name: YNR025C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005309
name: YNR026C
def: "Guanine nucleotide exchange factor \(GEF\); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog\, SED4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC12" EXACT []
synonym: "SED2" EXACT []
synonym: "Sar family guanine nucleotide exchange factor SEC12" EXACT []

[Term]
id: sgd:S000005310
name: YNR027W
def: "Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase \(PDXK\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD17" EXACT []
synonym: "putative pyridoxal kinase BUD17" EXACT []

[Term]
id: sgd:S000005311
name: YNR028W
def: "Peptidyl-prolyl cis-trans isomerase \(cyclophilin\); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog\, CPR4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPR8" EXACT []
synonym: "peptidylprolyl isomerase family protein CPR8" EXACT []

[Term]
id: sgd:S000005312
name: YNR029C
def: "Putative protein of unknown function; deletion confers reduced fitness in saline" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005313
name: YNR030W
def: "Alpha-1\,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1\,6 mannose to dolichol-linked Man7GlcNAc2\, acts in the dolichol pathway for N-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-mannosyltransferase" EXACT []
synonym: "ALG12" EXACT []
synonym: "ECM39" EXACT []
synonym: "dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000005314
name: YNR031C
def: "MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p\, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog\, SSK22\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSK2" EXACT []
synonym: "mitogen-activated protein kinase kinase kinase SSK2" EXACT []

[Term]
id: sgd:S000005315
name: YNR032W
def: "Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family\, required for glycogen accumulation; interacts with Tap42p\, which binds to and regulates other protein phosphatases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPG1" EXACT []
synonym: "putative serine/threonine-protein kinase PPG1" EXACT []

[Term]
id: sgd:S000005316
name: YNR033W
def: "Para-aminobenzoate \(PABA\) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid\, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4-amino-4-deoxychorismate synthase" EXACT []
synonym: "ABZ1" EXACT []

[Term]
id: sgd:S000005317
name: YNR034W
def: "Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog\, SOL2\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOL1" EXACT []

[Term]
id: sgd:S000005318
name: YNR035C
def: "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARC35" EXACT []
synonym: "END9" EXACT []

[Term]
id: sgd:S000005319
name: YNR036C
def: "Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS12" EXACT []
synonym: "putative mitochondrial 37S ribosomal protein MRPS12" EXACT []

[Term]
id: sgd:S000005320
name: YNR037C
def: "Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSM19" EXACT []
synonym: "mitochondrial 37S ribosomal protein RSM19" EXACT []

[Term]
id: sgd:S000005321
name: YNR038W
def: "Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP6" EXACT []

[Term]
id: sgd:S000005322
name: YNR039C
def: "Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZRG17" EXACT []
synonym: "Zn(2+) transporter ZRG17" EXACT []

[Term]
id: sgd:S000005323
name: YNR040W
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005324
name: YNR041C
def: "Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone \(coenzyme Q\) biosynthesis; human COQ2\, mutations in which are implicated in an increased risk of mutiple-system atrophy\, is able to complement a yeast coq2 null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "4-hydroxybenzoate octaprenyltransferase" EXACT []
synonym: "COQ2" EXACT []

[Term]
id: sgd:S000005325
name: YNR042W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005326
name: YNR043W
def: "Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols\, including ergosterol; acts as a homodimer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG19" EXACT []
synonym: "MVD1" EXACT []
synonym: "diphosphomevalonate decarboxylase MVD1" EXACT []

[Term]
id: sgd:S000005327
name: YNR044W
def: "Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall\, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog\, FIG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGA1" EXACT []

[Term]
id: sgd:S000005328
name: YNR045W
def: "Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET494" EXACT []

[Term]
id: sgd:S000005329
name: YNR046W
def: "Protein involved in methylation of tRNA\, rRNA\, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase \(MTase\) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p \(eRF1\) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM112" EXACT []

[Term]
id: sgd:S000005330
name: YNR047W
def: "Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members\, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits upstream inhibitory kinase\, Ypk1p; localizes to the cytoplasm\, early endosome/TGN compartments and thplasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; FPK1 has a paralog\, KIN82\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FPK1" EXACT []
synonym: "serine/threonine protein kinase FPK1" EXACT []

[Term]
id: sgd:S000005331
name: YNR048W
def: "Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog\, CDC50\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRF1" EXACT []
synonym: "putative aminophospholipid translocase regulatory protein" EXACT []

[Term]
id: sgd:S000005332
name: YNR049C
def: "Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSO1" EXACT []

[Term]
id: sgd:S000005333
name: YNR050C
def: "Saccharopine dehydrogenase \(NADP+\, L-glutamate-forming\); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde\, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: " L-glutamate-forming)" EXACT []
synonym: "LYS13" EXACT []
synonym: "LYS9" EXACT []
synonym: "saccharopine dehydrogenase (NADP+" EXACT []

[Term]
id: sgd:S000005334
name: YNR051C
def: "Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRE5" EXACT []

[Term]
id: sgd:S000005335
name: YNR052C
def: "RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF1" EXACT []
synonym: "CCR4-NOT core DEDD family RNase subunit POP2" EXACT []
synonym: "POP2" EXACT []

[Term]
id: sgd:S000005336
name: YNR053C
def: "Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOG2" EXACT []
synonym: "NUG2" EXACT []
synonym: "putative GTPase NOG2" EXACT []

[Term]
id: sgd:S000005337
name: YNR054C
def: "Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit \(SSU\) processome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABT1" EXACT []
synonym: "ESF2" EXACT []

[Term]
id: sgd:S000005338
name: YNR055C
def: "Putative transporter in the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOL1" EXACT []

[Term]
id: sgd:S000005339
name: YNR056C
def: "Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes \(BIO3\, BIO4\, and BIO5\) that mediate biotin synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIO5" EXACT []

[Term]
id: sgd:S000005340
name: YNR057C
def: "Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes \(BIO3\, BIO4\, and BIO5\) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer \(HGT\) from bacteria; expression appears to be repressed at low iron levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIO4" EXACT []
synonym: "dethiobiotin synthase" EXACT []

[Term]
id: sgd:S000005341
name: YNR058W
def: "7\,8-diamino-pelargonic acid aminotransferase \(DAPA\); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes \(BIO3\, BIO4\, and BIO5\) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer \(HGT\) from bacteria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIO3" EXACT []
synonym: "adenosylmethionine-8-amino-7-oxononanoate transaminase" EXACT []

[Term]
id: sgd:S000005342
name: YNR059W
def: "Putative alpha-1\,3-mannosyltransferase; not required for protein O-glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNT4" EXACT []

[Term]
id: sgd:S000005343
name: YNR060W
def: "Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE4" EXACT []

[Term]
id: sgd:S000005344
name: YNR061C
def: "Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005345
name: YNR062C
def: "Putative membrane protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005346
name: YNR063W
def: "Putative zinc-cluster protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005347
name: YNR064C
def: "Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "epoxide hydrolase" EXACT []

[Term]
id: sgd:S000005348
name: YNR065C
def: "Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSN1" EXACT []

[Term]
id: sgd:S000005349
name: YNR066C
def: "Putative membrane-localized protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005350
name: YNR067C
def: "Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSE4" EXACT []
synonym: "ENG1" EXACT []

[Term]
id: sgd:S000005351
name: YNR068C
def: "Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5\, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro\, but in a functionally different way than the non-readthrough form" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUL3" EXACT []

[Term]
id: sgd:S000005352
name: YNR069C
def: "Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC5" EXACT []
synonym: "BUL3" EXACT []

[Term]
id: sgd:S000005353
name: YNR070W
def: "Putative transporter of the ATP-binding cassette \(ABC\) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR18" EXACT []
synonym: "PDR18" EXACT []

[Term]
id: sgd:S000005354
name: YNR071C
def: "Putative aldose 1-epimerase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "aldose 1-epimerase superfamily protein" EXACT []

[Term]
id: sgd:S000005355
name: YNR072W
def: "Hexose transporter; up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7\, repressed by high levels of glucose; HXT17 has a paralog\, HXT13\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT17" EXACT []
synonym: "hexose transporter HXT17" EXACT []

[Term]
id: sgd:S000005356
name: YNR073C
def: "Putative mannitol dehydrogenase; YNR073C has a paralog\, DSF1\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative mannitol dehydrogenase" EXACT []

[Term]
id: sgd:S000005357
name: YNR074C
def: "Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli\, homolog of mammalian Apoptosis-Inducing Factor\, putative reductase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIF1" EXACT []
synonym: "CPD1" EXACT []

[Term]
id: sgd:S000005358
name: YNR075W
def: "Protein of unknown function; member of the DUP380 subfamily of conserved\, often subtelomerically-encoded proteins; may have a role in intracellular sterol transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COS10" EXACT []

[Term]
id: sgd:S000005359
name: YNR076W
def: "Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU6" EXACT []
synonym: "seripauperin PAU6" EXACT []

[Term]
id: sgd:S000005360
name: YNR077C
def: "Protein of unknown function\, abundance changes with carbon source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005361
name: YOL001W
def: "Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions\, including the response to phosphate limitation and stress-dependent calcium signaling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGS3" EXACT []
synonym: "PHO80" EXACT []
synonym: "TUP7" EXACT []
synonym: "VAC5" EXACT []
synonym: "phoR" EXACT []

[Term]
id: sgd:S000005362
name: YOL002C
def: "Plasma membrane receptor for plant antifungal protein\, osmotin; involved in zinc ion homeostasis\, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif \(IzRE\); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to the IzRE; transcription regulated by Zap1p\, zinc\, fatty acid levels; similar to mammalian adiponectins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IZH2" EXACT []
synonym: "PHO36" EXACT []

[Term]
id: sgd:S000005363
name: YOL003C
def: "Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFA4" EXACT []

[Term]
id: sgd:S000005364
name: YOL004W
def: "Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes\, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPE1" EXACT []
synonym: "GAM2" EXACT []
synonym: "RPD1" EXACT []
synonym: "SDI1" EXACT []
synonym: "SDS16" EXACT []
synonym: "SIN3" EXACT []
synonym: "UME4" EXACT []
synonym: "transcriptional regulator SIN3" EXACT []

[Term]
id: sgd:S000005365
name: YOL005C
def: "RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B12.5" EXACT []
synonym: "DNA-directed RNA polymerase II core subunit RPB11" EXACT []
synonym: "RPB11" EXACT []

[Term]
id: sgd:S000005366
name: YOL006C
def: "Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication\, transcription\, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA topoisomerase 1" EXACT []
synonym: "MAK1" EXACT []
synonym: "MAK17" EXACT []
synonym: "TOP1" EXACT []

[Term]
id: sgd:S000005367
name: YOL007C
def: "Protein of unknown function; green fluorescent protein \(GFP\)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSI2" EXACT []

[Term]
id: sgd:S000005368
name: YOL008W
def: "Coenzyme Q \(ubiquinone\) binding protein; functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ10" EXACT []

[Term]
id: sgd:S000005369
name: YOL009C
def: "Mitochondrial outer membrane protein\, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERMES complex subunit MDM12" EXACT []
synonym: "MDM12" EXACT []

[Term]
id: sgd:S000005370
name: YOL010W
def: "Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCL1" EXACT []

[Term]
id: sgd:S000005371
name: YOL011W
def: "Phospholipase B \(lysophospholipase\) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog\, PLB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLB3" EXACT []

[Term]
id: sgd:S000005372
name: YOL012C
def: "Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H2A.F/Z" EXACT []
synonym: "H2AZ" EXACT []
synonym: "HTA3" EXACT []
synonym: "HTZ1" EXACT []
synonym: "histone H2AZ" EXACT []

[Term]
id: sgd:S000005373
name: YOL013C
def: "Ubiquitin-protein ligase; functions in ER retention of misfolded proteins; required for ER-associated degradation \(ERAD\) of misfolded proteins; genetically linked to the unfolded protein response \(UPR\); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DER3" EXACT []
synonym: "E3 ubiquitin-protein ligase HRD1" EXACT []
synonym: "HRD1" EXACT []

[Term]
id: sgd:S000005374
name: YOL014W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005375
name: YOL015W
def: "Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC10" EXACT []

[Term]
id: sgd:S000005376
name: YOL016C
def: "Calmodulin-dependent protein kinase; may play a role in stress response\, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro\, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog\, CMK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMK2" EXACT []
synonym: "calmodulin-dependent protein kinase CMK2" EXACT []

[Term]
id: sgd:S000005377
name: YOL017W
def: "Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p\, which is a component of the RNA pol II mediator complex; ESC8 has a paralog\, IOC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESC8" EXACT []

[Term]
id: sgd:S000005378
name: YOL018C
def: "Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p\, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 \(Sx16\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TLG2" EXACT []

[Term]
id: sgd:S000005379
name: YOL019W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog\, DCV1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS7" EXACT []

[Term]
id: sgd:S000005380
name: YOL020W
def: "High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTG3" EXACT []
synonym: "SAB2" EXACT []
synonym: "SCM2" EXACT []
synonym: "TAP2" EXACT []
synonym: "TAT2" EXACT []
synonym: "aromatic amino acid transmembrane transporter TAT2" EXACT []

[Term]
id: sgd:S000005381
name: YOL021C
def: "Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; has similarity to E. coli RNase R and to human DIS3; mutations in Dis3p corresponding to human mutations implicated in multiple myeloma cause phenotypes suggesting impaired exosome function; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIS3" EXACT []
synonym: "MTR17" EXACT []
synonym: "RRP44" EXACT []
synonym: "exosome catalytic subunit DIS3" EXACT []

[Term]
id: sgd:S000005382
name: YOL022C
def: "Cytoplasmic protein required for correct processing of 20S pre-rRNA; protein required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSR4" EXACT []

[Term]
id: sgd:S000005383
name: YOL023W
def: "Mitochondrial translation initiation factor 2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IFM1" EXACT []
synonym: "translation initiation factor 2" EXACT []

[Term]
id: sgd:S000005384
name: YOL024W
def: "Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog\, IGD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005385
name: YOL025W
def: "Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit\, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM36" EXACT []
synonym: "LAG2" EXACT []

[Term]
id: sgd:S000005386
name: YOL026C
def: "Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments\, including Ugo1p\, Tom20p\, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIM1" EXACT []
synonym: "TOM13" EXACT []

[Term]
id: sgd:S000005387
name: YOL027C
def: "Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM38" EXACT []
synonym: "MKH1" EXACT []

[Term]
id: sgd:S000005388
name: YOL028C
def: "Putative basic leucine zipper \(bZIP\) transcription factor; YAP7 has a paralog\, YAP5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAP7" EXACT []

[Term]
id: sgd:S000005389
name: YOL029C
def: "Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005390
name: YOL030W
def: "1\,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAS5" EXACT []

[Term]
id: sgd:S000005391
name: YOL031C
def: "Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum \(ER\); homolog of Yarrowia lipolytica SLS1; GrpE-like protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIL1" EXACT []
synonym: "SLS1" EXACT []

[Term]
id: sgd:S000005392
name: YOL032W
def: "Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI10" EXACT []

[Term]
id: sgd:S000005393
name: YOL033W
def: "Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSE1" EXACT []
synonym: "glutamate--tRNA ligase MSE1" EXACT []

[Term]
id: sgd:S000005394
name: YOL034W
def: "Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA repair ATPase SMC5" EXACT []
synonym: "SMC5" EXACT []

[Term]
id: sgd:S000005395
name: YOL035C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005396
name: YOL036W
def: "Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog\, YIR016W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005397
name: YOL037C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005398
name: YOL038W
def: "Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit \(Pre9p\) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE6" EXACT []
synonym: "proteasome core particle subunit alpha 4" EXACT []

[Term]
id: sgd:S000005399
name: YOL039W
def: "Ribosomal protein P2 alpha; a component of the ribosomal stalk\, which is involved in the interaction between translational elongation factors and the ribosome; free \(non-ribosomal\) P2 stimulates the phosphorylation of the eIF2 alpha subunit \(Sui2p\) by Gcn2p; regulates the accumulation of P1 \(Rpp1Ap and Rpp1Bp\) in the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPL44" EXACT []
synonym: "RPLA2" EXACT []
synonym: "RPP2A" EXACT []
synonym: "ribosomal protein P2A" EXACT []

[Term]
id: sgd:S000005400
name: YOL040C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS15" EXACT []
synonym: "RPS21" EXACT []
synonym: "S15" EXACT []
synonym: "S19" EXACT []
synonym: "S21" EXACT []
synonym: "ribosomal 40S subunit protein S15" EXACT []
synonym: "rp52" EXACT []

[Term]
id: sgd:S000005401
name: YOL041C
def: "Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif \(RRM\); binds to Ebp2; similar to Nop13p and Nsr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP12" EXACT []

[Term]
id: sgd:S000005402
name: YOL042W
def: "Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NGL1" EXACT []

[Term]
id: sgd:S000005403
name: YOL043C
def: "DNA N-glycosylase and apurinic/apyrimidinic \(AP\) lyase; involved in base excision repair\, localizes to the nucleus; sumoylated; NTG2 has a paralog\, NTG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTG2" EXACT []
synonym: "SCR2" EXACT []
synonym: "bifunctional N-glycosylase/AP lyase NTG2" EXACT []

[Term]
id: sgd:S000005404
name: YOL044W
def: "Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAS21" EXACT []
synonym: "PEX15" EXACT []

[Term]
id: sgd:S000005405
name: YOL045W
def: "PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p \(sugar flux\) and Caf20p\, Tif11p and Sro9p \(translation\); PSK2 has a paralog\, PSK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSK2" EXACT []
synonym: "serine/threonine protein kinase PSK2" EXACT []

[Term]
id: sgd:S000005406
name: YOL046C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005407
name: YOL047C
def: "Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p\, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDS2" EXACT []

[Term]
id: sgd:S000005408
name: YOL048C
def: "Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein \(GFP\)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT8" EXACT []

[Term]
id: sgd:S000005409
name: YOL049W
def: "Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione \(GSH\) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GSH2" EXACT []
synonym: "glutathione synthase" EXACT []

[Term]
id: sgd:S000005410
name: YOL050C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005411
name: YOL051W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABE1" EXACT []
synonym: "GAL11" EXACT []
synonym: "MED15" EXACT []
synonym: "RAR3" EXACT []
synonym: "SDS4" EXACT []
synonym: "SPT13" EXACT []

[Term]
id: sgd:S000005412
name: YOL052C
def: "S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPE2" EXACT []
synonym: "adenosylmethionine decarboxylase SPE2" EXACT []

[Term]
id: sgd:S000005413
name: YOL052C-A
def: "Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog\, HOR7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDR2" EXACT []
synonym: "DDRA2" EXACT []
synonym: "YOL053C-A" EXACT []

[Term]
id: sgd:S000005414
name: YOL053W
def: "Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM39" EXACT []

[Term]
id: sgd:S000005415
name: YOL054W
def: "E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates poyubiquitination and degradation of Cse4p; prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSH1" EXACT []
synonym: "ubiquitin-protein ligase PSH1" EXACT []

[Term]
id: sgd:S000005416
name: YOL055C
def: "Trifunctional enzyme of thiamine biosynthesis\, degradation and salvage; has hydroxymethylpyrimidine \(HMP\) kinase\, HMP-phosphate \(HMP-P\) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI20" EXACT []
synonym: "trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase" EXACT []

[Term]
id: sgd:S000005417
name: YOL056W
def: "Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM3 has a paralog\, GPM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPM3" EXACT []
synonym: "phosphoglycerate mutase family protein GPM3" EXACT []

[Term]
id: sgd:S000005418
name: YOL057W
def: "Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "dipeptidyl-peptidase III" EXACT []

[Term]
id: sgd:S000005419
name: YOL058W
def: "Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG1" EXACT []
synonym: "ARG10" EXACT []
synonym: "argininosuccinate synthase" EXACT []

[Term]
id: sgd:S000005420
name: YOL059W
def: "NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog\, GPD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPD2" EXACT []
synonym: "GPD3" EXACT []
synonym: "glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2" EXACT []

[Term]
id: sgd:S000005421
name: YOL060C
def: "Protein required for normal mitochondrial morphology; has similarity to hemolysins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAM3" EXACT []

[Term]
id: sgd:S000005422
name: YOL061W
def: "5-phospho-ribosyl-1\(alpha\)-pyrophosphate synthetase; synthesizes PRPP\, which is required for nucleotide\, histidine\, and tryptophan biosynthesis; one of five related enzymes\, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRS5" EXACT []
synonym: "ribose phosphate diphosphokinase subunit PRS5" EXACT []

[Term]
id: sgd:S000005423
name: YOL062C
def: "Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization\, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone\, nutritional status and cell wall damage in S. cerevisiae\, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMP1" EXACT []
synonym: "APM4" EXACT []

[Term]
id: sgd:S000005424
name: YOL063C
def: "Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRT10" EXACT []
synonym: "HUS1" EXACT []

[Term]
id: sgd:S000005425
name: YOL064C
def: "Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate\, intermediates of the sulfate assimilation pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL2" EXACT []
synonym: "MET22" EXACT []

[Term]
id: sgd:S000005426
name: YOL065C
def: "Phosphatidylinositol 4\,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP54" EXACT []
synonym: "phosphoinositide 5-phosphatase INP54" EXACT []

[Term]
id: sgd:S000005427
name: YOL066C
def: "Bifunctional DRAP deaminase tRNA\:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog\, PUS9\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS8" EXACT []
synonym: "RIB2" EXACT []
synonym: "bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2" EXACT []

[Term]
id: sgd:S000005428
name: YOL067C
def: "Transcription factor \(bHLH\) involved in interorganelle communication; contributes to communication between mitochondria\, peroxisomes\, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTG1" EXACT []

[Term]
id: sgd:S000005429
name: YOL068C
def: "NAD\(+\)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog\, SIR2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HST1" EXACT []
synonym: "histone deacetylase HST1" EXACT []

[Term]
id: sgd:S000005430
name: YOL069W
def: "Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation\, spindle checkpoint activity\, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p\, Nuf2p\, Spc24p\, and Spc25p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUF2" EXACT []

[Term]
id: sgd:S000005431
name: YOL070C
def: "Protein of unknown function; localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes\, based on co-purification experiments; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NBA1" EXACT []

[Term]
id: sgd:S000005432
name: YOL071W
def: "Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment\, which is necessary for succinate dehydrogenase \(SDH\) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors \(paraganglioma\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EMI5" EXACT []
synonym: "SDH5" EXACT []
synonym: "succinate dehydrogenase assembly factor SDH5" EXACT []

[Term]
id: sgd:S000005433
name: YOL072W
def: "Nuclear pore-associated protein; component of TREX-2 complex \(Sac3p-Thp1p-Sus1p-Cdc31p\) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD29" EXACT []
synonym: "THP1" EXACT []

[Term]
id: sgd:S000005434
name: YOL073C
def: "Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSC2" EXACT []

[Term]
id: sgd:S000005435
name: YOL075C
def: "Putative ABC transporter" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005436
name: YOL076W
def: "Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEC1" EXACT []
synonym: "MDM20" EXACT []
synonym: "NAA25" EXACT []

[Term]
id: sgd:S000005437
name: YOL077C
def: "Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma\(70\)-like RNA-binding motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRX1" EXACT []

[Term]
id: sgd:S000005438
name: YOL078W
def: "Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AVO1" EXACT []

[Term]
id: sgd:S000005439
name: YOL079W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005440
name: YOL080C
def: "Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REX4" EXACT []

[Term]
id: sgd:S000005441
name: YOL081W
def: "GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form\, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog\, IRA1\, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCS1" EXACT []
synonym: "GLC4" EXACT []
synonym: "IRA2" EXACT []
synonym: "Ras GTPase activating protein IRA2" EXACT []

[Term]
id: sgd:S000005442
name: YOL082W
def: "Receptor protein for the cytoplasm-to-vacuole targeting \(Cvt\) pathway; delivers cargo proteins aminopeptidase I \(Ape1p\) and alpha-mannosidase \(Ams1p\) to the phagophore assembly site for packaging into Cvt vesicles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG19" EXACT []
synonym: "CVT19" EXACT []

[Term]
id: sgd:S000005443
name: YOL083W
def: "Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase \(Ams1p\); Atg19p paralog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG19-B" EXACT []
synonym: "ATG34" EXACT []

[Term]
id: sgd:S000005444
name: YOL084W
def: "Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM7" EXACT []

[Term]
id: sgd:S000005445
name: YOL085C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005446
name: YOL086C
def: "Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol\, the last step in the glycolytic pathway; ADH1 has a paralog\, ADH5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADC1" EXACT []
synonym: "ADH1" EXACT []
synonym: "alcohol dehydrogenase ADH1" EXACT []

[Term]
id: sgd:S000005447
name: YOL087C
def: "Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1\, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline\, sanguinarine\, and nordihydroguaiaretic acid" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DUF1" EXACT []

[Term]
id: sgd:S000005448
name: YOL088C
def: "Member of the protein disulfide isomerase \(PDI\) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPD2" EXACT []
synonym: "protein disulfide isomerase MPD2" EXACT []

[Term]
id: sgd:S000005449
name: YOL089C
def: "Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 \(Na+/Li+ extrusion pump\) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog\, TBS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL9" EXACT []

[Term]
id: sgd:S000005450
name: YOL090W
def: "Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSH2" EXACT []
synonym: "PMS5" EXACT []
synonym: "mismatch repair ATPase MSH2" EXACT []

[Term]
id: sgd:S000005451
name: YOL091W
def: "Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog\, YSW1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPC70" EXACT []
synonym: "SPO21" EXACT []

[Term]
id: sgd:S000005452
name: YOL092W
def: "Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family\, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog\, RTC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPQ1" EXACT []

[Term]
id: sgd:S000005453
name: YOL093W
def: "tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT \(SpoU-TrmD\) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM10" EXACT []

[Term]
id: sgd:S000005454
name: YOL094C
def: "Subunit of heteropentameric Replication factor C \(RF-C\); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen \(PCNA\) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFC4" EXACT []
synonym: "replication factor C subunit 4" EXACT []

[Term]
id: sgd:S000005455
name: YOL095C
def: "Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMI1" EXACT []

[Term]
id: sgd:S000005456
name: YOL096C
def: "O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone \(Coenzyme Q\) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COQ3" EXACT []
synonym: "hexaprenyldihydroxybenzoate methyltransferase" EXACT []

[Term]
id: sgd:S000005457
name: YOL097C
def: "Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRE342" EXACT []
synonym: "WRS1" EXACT []
synonym: "tryptophan--tRNA ligase WRS1" EXACT []

[Term]
id: sgd:S000005458
name: YOL098C
def: "Putative metalloprotease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005459
name: YOL099C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005460
name: YOL100W
def: "Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p\, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p; PKH2 has a paralog\, PKH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKH2" EXACT []
synonym: "serine/threonine protein kinase PKH2" EXACT []

[Term]
id: sgd:S000005461
name: YOL101C
def: "Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog\, IZH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IZH4" EXACT []

[Term]
id: sgd:S000005462
name: YOL102C
def: "tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing\: the transfer of the 2'-PO\(4\) from the splice junction to NAD\(+\) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPT1" EXACT []

[Term]
id: sgd:S000005463
name: YOL103W
def: "Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog\, ITR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRB612" EXACT []
synonym: "ITR2" EXACT []
synonym: "myo-inositol transporter ITR2" EXACT []

[Term]
id: sgd:S000005464
name: YOL104C
def: "Meiosis-specific telomere protein; required for bouquet formation\, effective homolog pairing\, ordered cross-over distribution\, sister chromatid cohesion at meiotic telomeres\, chromosomal segregation and telomere-led rapid prophase movement" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDJ1" EXACT []
synonym: "TAM1" EXACT []

[Term]
id: sgd:S000005465
name: YOL105C
def: "Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1\,3-beta-glucan synthesis; WSC3 has a paralog\, WSC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WSC3" EXACT []

[Term]
id: sgd:S000005466
name: YOL106W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005467
name: YOL107W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005468
name: YOL108C
def: "Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex\, with Ino2p\, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INO4" EXACT []

[Term]
id: sgd:S000005469
name: YOL109W
def: "Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZEO1" EXACT []

[Term]
id: sgd:S000005470
name: YOL110W
def: "Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERF4" EXACT []
synonym: "SHR5" EXACT []

[Term]
id: sgd:S000005471
name: YOL111C
def: "Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GET5" EXACT []
synonym: "MDY2" EXACT []
synonym: "TMA24" EXACT []

[Term]
id: sgd:S000005472
name: YOL112W
def: "GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p\, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog\, MSB3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSB4" EXACT []

[Term]
id: sgd:S000005473
name: YOL113W
def: "Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog\, CLA4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKM1" EXACT []
synonym: "putative serine/threonine protein kinase SKM1" EXACT []

[Term]
id: sgd:S000005474
name: YOL114C
def: "Putative protein of unknown function with similarity to human ICT1; has prokaryotic factors that may function in translation termination; YOL114C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005475
name: YOL115W
def: "Non-canonical poly\(A\) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs\, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity\, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAP2" EXACT []
synonym: "TRF4" EXACT []
synonym: "non-canonical poly(A) polymerase PAP2" EXACT []

[Term]
id: sgd:S000005476
name: YOL116W
def: "Transcriptional activator; involved in regulation of invertase and glucoamylase expression\, invasive growth and pseudohyphal differentiation\, iron uptake\, chromium accumulation\, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUP1" EXACT []
synonym: "HRB382" EXACT []
synonym: "MSN1" EXACT []
synonym: "MSS10" EXACT []
synonym: "PHD2" EXACT []

[Term]
id: sgd:S000005477
name: YOL117W
def: "Subunit of the COP9 signalosome \(CSN\) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSN10" EXACT []
synonym: "RRI2" EXACT []

[Term]
id: sgd:S000005478
name: YOL118C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005479
name: YOL119C
def: "Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCH4" EXACT []

[Term]
id: sgd:S000005480
name: YOL120C
def: "Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18\, no bacterial homolog; RPL18A has a paralog\, RPL18B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L18A" EXACT []
synonym: "L18e" EXACT []
synonym: "RP28A" EXACT []
synonym: "RPL18A" EXACT []
synonym: "ribosomal 60S subunit protein L18A" EXACT []
synonym: "rp28A" EXACT []

[Term]
id: sgd:S000005481
name: YOL121C
def: "Protein component of the small \(40S\) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19\, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog\, RPS19B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS19A" EXACT []
synonym: "S16aA" EXACT []
synonym: "S19A" EXACT []
synonym: "S19e" EXACT []
synonym: "YS16A" EXACT []
synonym: "ribosomal 40S subunit protein S19A" EXACT []
synonym: "rp55a" EXACT []

[Term]
id: sgd:S000005482
name: YOL122C
def: "Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SBS1" EXACT []
synonym: "SMF1" EXACT []
synonym: "divalent metal ion transporter SMF1" EXACT []

[Term]
id: sgd:S000005483
name: YOL123W
def: "Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly \(A\) signal sequences; required for genome stability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRP1" EXACT []
synonym: "NAB4" EXACT []
synonym: "NAB5" EXACT []

[Term]
id: sgd:S000005484
name: YOL124C
def: "Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 \(m2G10\) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM11" EXACT []

[Term]
id: sgd:S000005485
name: YOL125W
def: "2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold \(RFM\) superfamily of RNA methyltransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM13" EXACT []

[Term]
id: sgd:S000005486
name: YOL126C
def: "Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDH2" EXACT []
synonym: "malate dehydrogenase MDH2" EXACT []

[Term]
id: sgd:S000005487
name: YOL127W
def: "Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L23" EXACT []
synonym: "L25" EXACT []
synonym: "RPL25" EXACT []
synonym: "YL25" EXACT []
synonym: "ribosomal 60S subunit protein L25" EXACT []
synonym: "rpl6L" EXACT []

[Term]
id: sgd:S000005488
name: YOL128C
def: "Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs \(Mck1p\, Rim11p\, Mrk1p\, Ygk3p\) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog\, MCK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YGK3" EXACT []
synonym: "serine/threonine protein kinase YGK3" EXACT []

[Term]
id: sgd:S000005489
name: YOL129W
def: "Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS68" EXACT []

[Term]
id: sgd:S000005490
name: YOL130W
def: "Plasma membrane Mg\(2+\) transporter; expression and turnover are regulated by Mg\(2+\) concentration; overexpression confers increased tolerance to Al\(3+\) and Ga\(3+\) ions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALR1" EXACT []
synonym: "Mg(2+) transporter ALR1" EXACT []
synonym: "SWC3" EXACT []

[Term]
id: sgd:S000005491
name: YOL131W
def: "Putative protein of unknown function; YOL131W has a paralog\, STB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005492
name: YOL132W
def: "1\,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAS4" EXACT []

[Term]
id: sgd:S000005493
name: YOL133W
def: "RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box \(SCF\) that tethers the Cdc34p \(E2\) and Cdc53p \(cullin\) SCF subunits\, and is required for degradation of Gic2p\, Far1p\, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRT1" EXACT []
synonym: "HRT2" EXACT []
synonym: "RBX1" EXACT []
synonym: "ROC1" EXACT []
synonym: "SCF ubiquitin ligase complex subunit HRT1" EXACT []

[Term]
id: sgd:S000005494
name: YOL134C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps HRT1\, a verified gene that encodes an SCF ubiquitin ligase subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005495
name: YOL135C
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED7" EXACT []

[Term]
id: sgd:S000005496
name: YOL136C
def: "6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2\,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate\, expression induced by glucose and sucrose\, transcriptional regulation involves protein kinase A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PFK-2" EXACT []
synonym: "PFK27" EXACT []

[Term]
id: sgd:S000005497
name: YOL137W
def: "Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSC6" EXACT []

[Term]
id: sgd:S000005498
name: YOL138C
def: "Subunit of the SEA \(Seh1-associated\) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTC1" EXACT []
synonym: "SEA2" EXACT []

[Term]
id: sgd:S000005499
name: YOL139C
def: "mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G \(Tif4631p or Tif4632p\); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC33" EXACT []
synonym: "TIF45" EXACT []
synonym: "eIF4E" EXACT []
synonym: "translation initiation factor eIF4E" EXACT []

[Term]
id: sgd:S000005500
name: YOL140W
def: "Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG8" EXACT []
synonym: "acetylornithine transaminase" EXACT []

[Term]
id: sgd:S000005501
name: YOL141W
def: "AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine \(yW\)\, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPM2" EXACT []
synonym: "TYW4" EXACT []

[Term]
id: sgd:S000005502
name: YOL142W
def: "Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p \(EXOSC3\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MTR14" EXACT []
synonym: "RRP40" EXACT []

[Term]
id: sgd:S000005503
name: YOL143C
def: "Lumazine synthase \(DMRL synthase\); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6\,7-dimethyl-8-ribityllumazine synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIB4" EXACT []
synonym: "lumazine synthase RIB4" EXACT []

[Term]
id: sgd:S000005504
name: YOL144W
def: "Nucleolar protein required for 60S ribosomal subunit biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP8" EXACT []

[Term]
id: sgd:S000005505
name: YOL145C
def: "Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes\, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDP1" EXACT []
synonym: "CTR9" EXACT []

[Term]
id: sgd:S000005506
name: YOL146W
def: "Subunit of the GINS complex \(Sld5p\, Psf1p\, Psf2p\, Psf3p\); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSF3" EXACT []

[Term]
id: sgd:S000005507
name: YOL147C
def: "Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation\, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX11" EXACT []
synonym: "PMP24" EXACT []
synonym: "PMP27" EXACT []

[Term]
id: sgd:S000005508
name: YOL148C
def: "Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on \(GLRO\) assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADA5" EXACT []
synonym: "SPT20" EXACT []

[Term]
id: sgd:S000005509
name: YOL149W
def: "Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCP1" EXACT []
synonym: "MRT2" EXACT []

[Term]
id: sgd:S000005510
name: YOL150C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005511
name: YOL151W
def: "3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced \(osmotic\, ionic\, oxidative\, heat shock and heavy metals\); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase \(NADPH-dependent\) is also known as D-lactaldehyde dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRE2" EXACT []
synonym: "methylglyoxal reductase (NADPH-dependent) GRE2" EXACT []

[Term]
id: sgd:S000005512
name: YOL152W
def: "Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE7" EXACT []

[Term]
id: sgd:S000005514
name: YOL154W
def: "Putative GPI-anchored protein; transcription is induced under low-zinc conditions\, as mediated by the Zap1p transcription factor\, and at alkaline pH" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ZPS1" EXACT []

[Term]
id: sgd:S000005515
name: YOL155C
def: "Haze-protective mannoprotein; reduces the particle size of aggregated proteins in white wines" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPF1" EXACT []

[Term]
id: sgd:S000005516
name: YOL156W
def: "Putative hexose transporter that is nearly identical to Hxt9p; has similarity to major facilitator superfamily \(MFS\) transporters and is involved in pleiotropic drug resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HXT11" EXACT []
synonym: "LGT3" EXACT []
synonym: "hexose transporter HXT11" EXACT []

[Term]
id: sgd:S000005517
name: YOL157C
def: "Isomaltase \(alpha-1\,6-glucosidase/alpha-methylglucosidase\); preferred specificity for isomaltose\, alpha-methylglucoside\, and palatinose\, but also exhibits alpha-1\,2 glucosidase activity on sucrose and kojibiose\, and can cleave the 1\,3-alpha linkage of nigerose and turanose and the alpha-1\,5 linkage of leucrose in vitro; not required for isomaltose utilization\, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase IMA2" EXACT []
synonym: "IMA2" EXACT []
synonym: "oligo-1" EXACT []

[Term]
id: sgd:S000005518
name: YOL158C
def: "Endosomal ferric enterobactin transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARN4" EXACT []
synonym: "ENB1" EXACT []

[Term]
id: sgd:S000005519
name: YOL159C
def: "Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005520
name: YOL160W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005521
name: YOL161C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU20" EXACT []
synonym: "seripauperin PAU20" EXACT []

[Term]
id: sgd:S000005522
name: YOL162W
def: "Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005523
name: YOL163W
def: "Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005524
name: YOL164W
def: "Bacterially-derived sulfatase; required for use of alkyl- and aryl-sulfates as sulfur sources" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BDS1" EXACT []

[Term]
id: sgd:S000005525
name: YOL165C
def: "Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog\, AAD3\, that arose from a segmental duplication; members of the AAD gene family comprise three pairs \(AAD3 + AAD15\, AAD6/AAD16 + AAD4\, AAD10 + AAD14\) whose two genes are more related to one another than to other members of the family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAD15" EXACT []

[Term]
id: sgd:S000005526
name: YOL166C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005527
name: YOR001W
def: "Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing\, maturation\, surveillance\, degradation\, tethering\, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 \(EXOSC10\); mutant displays reduced transcription elongation in the G-less-based" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP6" EXACT []
synonym: "exosome nuclease subunit RRP6" EXACT []

[Term]
id: sgd:S000005528
name: YOR002W
def: "Alpha 1\,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-glucosyltransferase" EXACT []
synonym: "ALG6" EXACT []
synonym: "dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000005529
name: YOR003W
def: "Putative precursor to the subtilisin-like protease III; YSP3 has a paralog\, PRB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YSP3" EXACT []
synonym: "putative subtilisin-like protease YSP3" EXACT []

[Term]
id: sgd:S000005530
name: YOR004W
def: "Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p\, although the PINc domain of Utp23p is not required for function; essential protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UTP23" EXACT []

[Term]
id: sgd:S000005531
name: YOR005C
def: "DNA ligase required for nonhomologous end-joining \(NHEJ\); forms stable heterodimer with required cofactor Lif1p\, interacts with Nej1p; involved in meiosis\, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA ligase (ATP) DNL4" EXACT []
synonym: "DNL4" EXACT []
synonym: "LIG4" EXACT []

[Term]
id: sgd:S000005532
name: YOR006C
def: "Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSR3" EXACT []

[Term]
id: sgd:S000005533
name: YOR007C
def: "Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4\, Get5p\, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGT2" EXACT []

[Term]
id: sgd:S000005534
name: YOR008C
def: "Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HCS77" EXACT []
synonym: "SLG1" EXACT []
synonym: "WSC1" EXACT []

[Term]
id: sgd:S000005535
name: YOR009W
def: "Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIR4" EXACT []

[Term]
id: sgd:S000005536
name: YOR010C
def: "Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog\, TIR3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP2" EXACT []
synonym: "TIR2" EXACT []

[Term]
id: sgd:S000005537
name: YOR011W
def: "Plasma membrane sterol transporter of the ATP-binding cassette family; required\, along with Pdr11p\, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog\, PDR11\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette sterol transporter AUS1" EXACT []
synonym: "AUS1" EXACT []

[Term]
id: sgd:S000005538
name: YOR012W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005539
name: YOR013W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC11" EXACT []

[Term]
id: sgd:S000005540
name: YOR014W
def: "B-type regulatory subunit of protein phosphatase 2A \(PP2A\); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits\, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis\, for ring disassembly in G1 and for dephosphorylation of septin\, Shs1p; homolog of the mammalian B' subunit of PP2A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTS1" EXACT []
synonym: "SCS1" EXACT []
synonym: "protein phosphatase 2A regulatory subunit RTS1" EXACT []

[Term]
id: sgd:S000005541
name: YOR015W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005542
name: YOR016C
def: "Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog\, ERP2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERP4" EXACT []

[Term]
id: sgd:S000005543
name: YOR017W
def: "Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET127" EXACT []

[Term]
id: sgd:S000005544
name: YOR018W
def: "Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p\, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog\, ROG3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART4" EXACT []
synonym: "ROD1" EXACT []

[Term]
id: sgd:S000005545
name: YOR019W
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; YOR019W has a paralog\, JIP4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005546
name: YOR020C
def: "Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p\, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPN10" EXACT []
synonym: "HSP10" EXACT []

[Term]
id: sgd:S000005547
name: YOR021C
def: "SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFM1" EXACT []

[Term]
id: sgd:S000005548
name: YOR022C
def: "Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative carboxylic ester hydrolase" EXACT []

[Term]
id: sgd:S000005549
name: YOR023C
def: "Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AHC1" EXACT []

[Term]
id: sgd:S000005550
name: YOR024W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC12" EXACT []

[Term]
id: sgd:S000005551
name: YOR025W
def: "Member of the Sir2 family of NAD\(+\)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing\, cell cycle progression\, radiation resistance\, genomic stability and short-chain fatty acid metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HST3" EXACT []

[Term]
id: sgd:S000005552
name: YOR026W
def: "Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase\, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p\, binds Mad2p and Mad3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUB3" EXACT []
synonym: "PAC9" EXACT []

[Term]
id: sgd:S000005553
name: YOR027W
def: "Hsp90 cochaperone; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Hsp90 cochaperone STI1" EXACT []
synonym: "STI1" EXACT []

[Term]
id: sgd:S000005554
name: YOR028C
def: "Basic leucine zipper \(bZIP\) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog\, YAP6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIN5" EXACT []
synonym: "HAL6" EXACT []
synonym: "YAP4" EXACT []

[Term]
id: sgd:S000005555
name: YOR029W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005556
name: YOR030W
def: "Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFG16" EXACT []
synonym: "ECM41" EXACT []
synonym: "ZRG12" EXACT []

[Term]
id: sgd:S000005558
name: YOR032C
def: "bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMS1" EXACT []

[Term]
id: sgd:S000005559
name: YOR033C
def: "5'-3' exonuclease and flap-endonuclease; involved in recombination\, double-strand break repair\, MMS2 error-free branch of the post replication \(PRR\) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family\, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog\, DIN7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHS1" EXACT []
synonym: "EXO1" EXACT []
synonym: "Rad2 family nuclease EXO1" EXACT []

[Term]
id: sgd:S000005560
name: YOR034C
def: "Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich \(DHHC-CRD\) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog\, AKR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AKR2" EXACT []

[Term]
id: sgd:S000005561
name: YOR035C
def: "Protein containing a UCS \(UNC-45/CRO1/SHE4\) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis\, polarization of the actin cytoskeleton\, and asymmetric mRNA localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIM1" EXACT []
synonym: "SHE4" EXACT []

[Term]
id: sgd:S000005562
name: YOR036W
def: "Target membrane receptor \(t-SNARE\); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic\, endocytic\, and retrograde traffic into the prevacuolar compartment; syntaxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP12" EXACT []
synonym: "SNAP receptor PEP12" EXACT []
synonym: "VPL6" EXACT []
synonym: "VPS6" EXACT []
synonym: "VPT13" EXACT []

[Term]
id: sgd:S000005563
name: YOR037W
def: "Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 \(Cyc1p and Cyt1p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYC2" EXACT []

[Term]
id: sgd:S000005564
name: YOR038C
def: "Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIR2" EXACT []
synonym: "SPT1" EXACT []

[Term]
id: sgd:S000005565
name: YOR039W
def: "Beta' regulatory subunit of casein kinase 2 \(CK2\); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2\, comprised of CKA1\, CKA2\, CKB1 and CKB2\, has many substrates including transcription factors and all RNA polymerase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKB2" EXACT []
synonym: "casein kinase 2 regulatory subunit CKB2" EXACT []

[Term]
id: sgd:S000005566
name: YOR040W
def: "Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog\, GLO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLO4" EXACT []
synonym: "hydroxyacylglutathione hydrolase GLO4" EXACT []

[Term]
id: sgd:S000005567
name: YOR041C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRF5" EXACT []

[Term]
id: sgd:S000005568
name: YOR042W
def: "Ubiquitin-binding protein; functions as a ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; contains a CUE domain that binds ubiquitin\, which may facilitate intramolecular monoubiquitination; GFP-fusion protein localizes to the cytoplasm in a punctate pattern; CUE5 has a paralog\, DON1\, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog\, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUE5" EXACT []

[Term]
id: sgd:S000005569
name: YOR043W
def: "Protein required for full activation of the general stress response; required with binding partner Psr1p\, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WHI2" EXACT []

[Term]
id: sgd:S000005570
name: YOR044W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog\, BSC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC23" EXACT []

[Term]
id: sgd:S000005571
name: YOR045W
def: "Component of the TOM \(translocase of outer membrane\) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISP6" EXACT []
synonym: "MOM8B" EXACT []
synonym: "TOM6" EXACT []

[Term]
id: sgd:S000005572
name: YOR046C
def: "Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus\, remodeling messenger ribonucleoprotein particles \(mRNPs\)\, with ATPase activity stimulated by Gle1p\, IP6 and Nup159p; involved in translation termination along with Sup45p \(eRF1\); role in the cellular response to heat stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-dependent RNA helicase DBP5" EXACT []
synonym: "DBP5" EXACT []
synonym: "RAT8" EXACT []

[Term]
id: sgd:S000005573
name: YOR047C
def: "Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p\, glucose sensors Snf3p and Rgt2p\, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate \[GAR+\]; STD1 has a paralog\, MTH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSN3" EXACT []
synonym: "SFS3" EXACT []
synonym: "STD1" EXACT []

[Term]
id: sgd:S000005574
name: YOR048C
def: "Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism\, including rRNA and snRNA processing as well as poly \(A+\) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HKE1" EXACT []
synonym: "RAT1" EXACT []
synonym: "TAP1" EXACT []
synonym: "XRN2" EXACT []
synonym: "ssRNA exonuclease RAT1" EXACT []

[Term]
id: sgd:S000005575
name: YOR049C
def: "Suppressor of sphingoid LCB sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport long chain bases \(LCBs\) from the cytoplasmic side toward the extracytoplasmic side of the membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSB1" EXACT []
synonym: "phospholipid-translocating ATPase RSB1" EXACT []

[Term]
id: sgd:S000005576
name: YOR050C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant is viable" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOR29-01" EXACT []

[Term]
id: sgd:S000005577
name: YOR051C
def: "Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ETT1" EXACT []
synonym: "NRO1" EXACT []
synonym: "YOR29-02" EXACT []

[Term]
id: sgd:S000005578
name: YOR052C
def: "AN1-type zinc finger protein of unknown function; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element\, a transcriptional profile similar to CUZ1 and RPN2\, and decreased expression in an RPN4 mutant; induced by nitrogen limitation and weak acid; ortholog of human AIRAP\, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TMC1" EXACT []
synonym: "YOR29-03" EXACT []

[Term]
id: sgd:S000005579
name: YOR053W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOR29-04" EXACT []

[Term]
id: sgd:S000005580
name: YOR054C
def: "Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase \(PPCDC; Cab3p\, Sis2p\, Vhs3p\) complex and the CoA-Synthesizing Protein Complex \(CoA-SPC\: Cab2p\, Cab3p\, Cab4p\, Cab5p\, Sis2p and Vhs3p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VHS3" EXACT []
synonym: "YOR29-05" EXACT []
synonym: "phosphopantothenoylcysteine decarboxylase complex subunit VHS3" EXACT []

[Term]
id: sgd:S000005581
name: YOR055W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOR29-06" EXACT []

[Term]
id: sgd:S000005582
name: YOR056C
def: "Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p\, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOB1" EXACT []
synonym: "YOR29-07" EXACT []

[Term]
id: sgd:S000005583
name: YOR057W
def: "Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF \(Skp1p/Cdc53p/F box protein\) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGT1" EXACT []
synonym: "YOR29-08" EXACT []

[Term]
id: sgd:S000005584
name: YOR058C
def: "Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein \(MAP\) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASE1" EXACT []
synonym: "YOR29-09" EXACT []

[Term]
id: sgd:S000005585
name: YOR059C
def: "Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet \(LD\) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPL1" EXACT []
synonym: "YOR29-10" EXACT []
synonym: "putative hydrolase" EXACT []

[Term]
id: sgd:S000005586
name: YOR060C
def: "Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLD7" EXACT []
synonym: "YOR29-11" EXACT []

[Term]
id: sgd:S000005587
name: YOR061W
def: "Alpha' catalytic subunit of casein kinase 2 \(CK2\); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2\, comprised of CKA1\, CKA2\, CKB1 and CKB2\, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CKA2" EXACT []
synonym: "YOR29-12" EXACT []
synonym: "casein kinase 2 catalytic subunit CKA2" EXACT []

[Term]
id: sgd:S000005588
name: YOR062C
def: "Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog\, YKR075C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOR29-13" EXACT []

[Term]
id: sgd:S000005589
name: YOR063W
def: "Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L3" EXACT []
synonym: "MAK8" EXACT []
synonym: "RPL3" EXACT []
synonym: "TCM1" EXACT []
synonym: "YL1" EXACT []
synonym: "YOR29-14" EXACT []
synonym: "ribosomal 60S subunit protein L3" EXACT []
synonym: "rp1" EXACT []

[Term]
id: sgd:S000005590
name: YOR064C
def: "Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3\, has similarity to the human tumor suppressor ING1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YNG1" EXACT []
synonym: "YOR29-15" EXACT []

[Term]
id: sgd:S000005591
name: YOR065W
def: "Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated\, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTC1" EXACT []
synonym: "CYT1" EXACT []
synonym: "YOR29-16" EXACT []
synonym: "ubiquinol--cytochrome-c reductase catalytic subunit CYT1" EXACT []

[Term]
id: sgd:S000005592
name: YOR066W
def: "Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog\, MSA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSA1" EXACT []
synonym: "YOR29-17" EXACT []

[Term]
id: sgd:S000005593
name: YOR067C
def: "Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3-glucosyltransferase" EXACT []
synonym: "ALG8" EXACT []
synonym: "YOR29-18" EXACT []
synonym: "dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1" EXACT []

[Term]
id: sgd:S000005594
name: YOR068C
def: "Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAM10" EXACT []
synonym: "YOR29-19" EXACT []

[Term]
id: sgd:S000005595
name: YOR069W
def: "Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog\, YKR078W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD2" EXACT []
synonym: "PEP10" EXACT []
synonym: "VPS5" EXACT []
synonym: "VPT5" EXACT []
synonym: "YOR29-20" EXACT []

[Term]
id: sgd:S000005596
name: YOR070C
def: "Cis-golgi GTPase-activating protein \(GAP\) for yeast Rabs; the Rab family members are Ypt1p \(in vivo\) and for Ypt1p\, Sec4p\, Ypt7p\, and Ypt51p \(in vitro\); involved in vesicle docking and fusion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP1" EXACT []
synonym: "YOR29-21" EXACT []

[Term]
id: sgd:S000005597
name: YOR071C
def: "High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside \(acadesine\) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NRT1" EXACT []
synonym: "THI71" EXACT []
synonym: "YOR29-22" EXACT []

[Term]
id: sgd:S000005598
name: YOR072W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate\, paraquat and wortmannin sensitive" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOR29-23" EXACT []

[Term]
id: sgd:S000005599
name: YOR073W
def: "Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGO1" EXACT []
synonym: "YOR29-24" EXACT []

[Term]
id: sgd:S000005600
name: YOR074C
def: "Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC21" EXACT []
synonym: "CRT9" EXACT []
synonym: "TMP1" EXACT []
synonym: "YOR29-25" EXACT []
synonym: "thymidylate synthase" EXACT []

[Term]
id: sgd:S000005601
name: YOR075W
def: "t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p\, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UFE1" EXACT []
synonym: "YOR29-26" EXACT []

[Term]
id: sgd:S000005602
name: YOR076C
def: "Coupling protein for the Ski complex and cytoplasmic exosome; involved in 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype; SKI7 has a paralog\, HBS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKI7" EXACT []
synonym: "YOR29-27" EXACT []

[Term]
id: sgd:S000005603
name: YOR077W
def: "Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTS2" EXACT []
synonym: "YOR29-28" EXACT []

[Term]
id: sgd:S000005604
name: YOR078W
def: "Component of small ribosomal subunit \(SSU\) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag\:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD21" EXACT []
synonym: "UTP16" EXACT []
synonym: "YOR29-29" EXACT []

[Term]
id: sgd:S000005605
name: YOR079C
def: "Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 \(copper\, zinc superoxide dismutase\) null mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATX2" EXACT []
synonym: "Mn(2+) transporter ATX2" EXACT []
synonym: "YOR29-30" EXACT []

[Term]
id: sgd:S000005606
name: YOR080W
def: "Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitylation of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase\, completion of DNA replication during recovery from DNA damage\, assembly of RSC complex\, RSC-mediated transcription regulation\, and nucleosome positioning; involved in invasive and pseudohyphal growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIA2" EXACT []
synonym: "DNA-binding SCF ubiquitin ligase subunit DIA2" EXACT []
synonym: "YOR29-31" EXACT []

[Term]
id: sgd:S000005607
name: YOR081C
def: "Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol \(TAG\) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid \(LPA\); potential Cdc28p substrate; TGL5 has a paralog\, TGL4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STC2" EXACT []
synonym: "TGL5" EXACT []

[Term]
id: sgd:S000005608
name: YOR082C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005609
name: YOR083W
def: "Repressor of G1 transcription; binds to SCB binding factor \(SBF\) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK\, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1; WHI5 has a paralog\, SRL3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WHI5" EXACT []
synonym: "transcriptional repressor WHI5" EXACT []

[Term]
id: sgd:S000005610
name: YOR084W
def: "Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 \(PTS1\) and a lipase motif; peroxisomal import requires the PTS1 receptor\, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPX1" EXACT []

[Term]
id: sgd:S000005611
name: YOR085W
def: "Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OST3" EXACT []

[Term]
id: sgd:S000005612
name: YOR086C
def: "Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p\, Tcb2p and Tcb3p interact; TCB1 has a paralog\, TCB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCB1" EXACT []

[Term]
id: sgd:S000005613
name: YOR087W
def: "Vacuolar cation channel; mediates release of Ca\(2+\) from the vacuole in response to hyperosmotic shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRPY1" EXACT []
synonym: "YOR088W" EXACT []
synonym: "YVC1" EXACT []

[Term]
id: sgd:S000005615
name: YOR089C
def: "Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog\, YPT53\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Rab family GTPase VPS21" EXACT []
synonym: "VPS12" EXACT []
synonym: "VPS21" EXACT []
synonym: "VPT12" EXACT []
synonym: "YPT21" EXACT []
synonym: "YPT51" EXACT []

[Term]
id: sgd:S000005616
name: YOR090C
def: "Mitochondrial type 2C protein phosphatase \(PP2C\); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease \(Imp1p-Imp2p\); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPP1" EXACT []
synonym: "PTC5" EXACT []
synonym: "type 2C protein phosphatase PTC5" EXACT []

[Term]
id: sgd:S000005617
name: YOR091W
def: "Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF46" EXACT []
synonym: "TMA46" EXACT []

[Term]
id: sgd:S000005618
name: YOR092W
def: "Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog\, YNL095C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM3" EXACT []
synonym: "YOR3165W" EXACT []
synonym: "putative ATPase ECM3" EXACT []

[Term]
id: sgd:S000005619
name: YOR093C
def: "Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005620
name: YOR094W
def: "Glucose-repressible ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulating cell polarity and invasive growth; also has mRNA binding activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARF3" EXACT []
synonym: "ARL2" EXACT []
synonym: "Arf family GTPase ARF3" EXACT []

[Term]
id: sgd:S000005621
name: YOR095C
def: "Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKI1" EXACT []
synonym: "ribose-5-phosphate isomerase RKI1" EXACT []

[Term]
id: sgd:S000005622
name: YOR096W
def: "Protein component of the small \(40S\) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7\, no bacterial homolog; RPS7A has a paralog\, RPS7B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS30" EXACT []
synonym: "RPS7A" EXACT []
synonym: "S7A" EXACT []
synonym: "S7e" EXACT []
synonym: "ribosomal 40S subunit protein S7A" EXACT []
synonym: "rp30" EXACT []

[Term]
id: sgd:S000005623
name: YOR097C
def: "Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005624
name: YOR098C
def: "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex \(NPC\) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FG-nucleoporin NUP1" EXACT []
synonym: "NUP1" EXACT []

[Term]
id: sgd:S000005625
name: YOR099W
def: "Alpha-1\,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-mannosyltransferase KTR1" EXACT []
synonym: "KTR1" EXACT []
synonym: "alpha-1" EXACT []

[Term]
id: sgd:S000005626
name: YOR100C
def: "Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRC1" EXACT []

[Term]
id: sgd:S000005627
name: YOR101W
def: "GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog\, RAS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAS1" EXACT []
synonym: "Ras family GTPase RAS1" EXACT []

[Term]
id: sgd:S000005628
name: YOR102W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005629
name: YOR103C
def: "Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OST2" EXACT []

[Term]
id: sgd:S000005630
name: YOR104W
def: "Exomer-dependent cargo protein; induces appearance of \[PIN+\] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PIN2" EXACT []

[Term]
id: sgd:S000005631
name: YOR105W
def: "Protein of unknown function; expressed at both mRNA and protein levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005632
name: YOR106W
def: "Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTH1" EXACT []
synonym: "SNAP receptor VAM3" EXACT []
synonym: "VAM3" EXACT []

[Term]
id: sgd:S000005633
name: YOR107W
def: "Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGS2" EXACT []

[Term]
id: sgd:S000005634
name: YOR108W
def: "Alpha-isopropylmalate synthase II \(2-isopropylmalate synthase\); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme\, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog\, LEU4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "2-isopropylmalate synthase LEU9" EXACT []
synonym: "LEU9" EXACT []

[Term]
id: sgd:S000005635
name: YOR109W
def: "Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog\, INP52\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "INP53" EXACT []
synonym: "SJL3" EXACT []
synonym: "SOP2" EXACT []
synonym: "phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53" EXACT []

[Term]
id: sgd:S000005636
name: YOR110W
def: "RNA pol III transcription initiation factor complex \(TFIIIC\) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog\, YNL108C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFC7" EXACT []
synonym: "tau 55" EXACT []
synonym: "transcription factor TFIIIC subunit TFC7" EXACT []

[Term]
id: sgd:S000005637
name: YOR111W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005638
name: YOR112W
def: "Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p\, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC\, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CEX1" EXACT []

[Term]
id: sgd:S000005639
name: YOR113W
def: "Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose\, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources\, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AZF1" EXACT []

[Term]
id: sgd:S000005640
name: YOR114W
def: "Putative protein of unknown function; null mutant is viable" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005641
name: YOR115C
def: "Core component of transport protein particle \(TRAPP\) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p\, regulating ER-Golgi traffic \(TRAPPI\)\, intra-Golgi traffic \(TRAPPII\)\, endosome-Golgi traffic \(TRAPPII and III\) and autophagy \(TRAPPIII\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRS33" EXACT []

[Term]
id: sgd:S000005642
name: YOR116C
def: "RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C160" EXACT []
synonym: "DNA-directed RNA polymerase III core subunit RPO31" EXACT []
synonym: "RPC1" EXACT []
synonym: "RPC160" EXACT []
synonym: "RPO31" EXACT []

[Term]
id: sgd:S000005643
name: YOR117W
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPT5" EXACT []
synonym: "YTA1" EXACT []
synonym: "proteasome regulatory particle base subunit RPT5" EXACT []

[Term]
id: sgd:S000005644
name: YOR118W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RTC5" EXACT []

[Term]
id: sgd:S000005645
name: YOR119C
def: "Serine kinase involved in cell cycling and pre-rRNA processing; associated with late pre-40S particles via its conserved C-terminal domain and participates in late 40S biogenesis; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIO1" EXACT []
synonym: "RRP10" EXACT []
synonym: "protein kinase RIO1" EXACT []

[Term]
id: sgd:S000005646
name: YOR120W
def: "Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase \(AKR\) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog\, YPR1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCY" EXACT []
synonym: "GCY1" EXACT []
synonym: "glycerol 2-dehydrogenase (NADP(+)) GCY1" EXACT []

[Term]
id: sgd:S000005647
name: YOR121C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005648
name: YOR122C
def: "Profilin; binds actin\, phosphatidylinositol 4\,5-bisphosphate\, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 \(profilin 1\) complements temperature sensitive pfy1 mutants\, PFN1 mutations are a rare cause of ALS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS5" EXACT []
synonym: "PFY1" EXACT []
synonym: "PRF1" EXACT []
synonym: "profilin" EXACT []

[Term]
id: sgd:S000005649
name: YOR123C
def: "Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on \(GLRO\) assay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEO1" EXACT []

[Term]
id: sgd:S000005650
name: YOR124C
def: "Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP2" EXACT []

[Term]
id: sgd:S000005651
name: YOR125C
def: "Protein required for ubiquinone \(Coenzyme Q\) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAT5" EXACT []
synonym: "COQ7" EXACT []
synonym: "putative monooxygenase CAT5" EXACT []

[Term]
id: sgd:S000005652
name: YOR126C
def: "Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate\, which is particularly important in sake brewing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IAH1" EXACT []

[Term]
id: sgd:S000005653
name: YOR127W
def: "GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization\, pheromone response\, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog\, RGA2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBM1" EXACT []
synonym: "RGA1" EXACT []
synonym: "THE1" EXACT []

[Term]
id: sgd:S000005654
name: YOR128C
def: "Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE2" EXACT []
synonym: "phosphoribosylaminoimidazole carboxylase ADE2" EXACT []

[Term]
id: sgd:S000005655
name: YOR129C
def: "Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor\, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFI1" EXACT []

[Term]
id: sgd:S000005656
name: YOR130C
def: "Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria \(HHH\) syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARG11" EXACT []
synonym: "ORT1" EXACT []

[Term]
id: sgd:S000005657
name: YOR131C
def: "Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative haloacid dehalogenase-like hydrolase" EXACT []

[Term]
id: sgd:S000005658
name: YOR132W
def: "Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP21" EXACT []
synonym: "VPS17" EXACT []
synonym: "VPT3" EXACT []

[Term]
id: sgd:S000005659
name: YOR133W
def: "Elongation factor 2 \(EF-2\)\, also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide\, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog\, EFT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFT1" EXACT []
synonym: "elongation factor 2" EXACT []

[Term]
id: sgd:S000005660
name: YOR134W
def: "Rho GTPase activating protein \(RhoGAP\); stimulates the intrinsic GTPase activity of Rho1p\, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis\, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog\, SAC7\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BAG7" EXACT []

[Term]
id: sgd:S000005661
name: YOR135C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC14" EXACT []

[Term]
id: sgd:S000005662
name: YOR136W
def: "Subunit of mitochondrial NAD\(+\)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IDH2" EXACT []
synonym: "isocitrate dehydrogenase (NAD(+)) IDH2" EXACT []

[Term]
id: sgd:S000005663
name: YOR137C
def: "Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SIA1" EXACT []

[Term]
id: sgd:S000005664
name: YOR138C
def: "Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY \(residues 131-135\) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RUP1" EXACT []

[Term]
id: sgd:S000005665
name: YOR139C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005666
name: YOR140W
def: "Transcriptional repressor and activator; involved in repression of flocculation-related genes\, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon \(C1430T\, Q477-stop\) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 \(S288C\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFL1" EXACT []

[Term]
id: sgd:S000005667
name: YOR141C
def: "Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP8" EXACT []

[Term]
id: sgd:S000005668
name: YOR142W
def: "Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSC1" EXACT []
synonym: "succinate--CoA ligase (GDP-forming) subunit alpha" EXACT []

[Term]
id: sgd:S000005669
name: YOR143C
def: "Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate \(thiamine diphosphate\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI80" EXACT []
synonym: "thiamine diphosphokinase" EXACT []

[Term]
id: sgd:S000005670
name: YOR144C
def: "Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA \(Pol30p\) unloading during DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELG1" EXACT []
synonym: "RTT110" EXACT []

[Term]
id: sgd:S000005671
name: YOR145C
def: "Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p\, an 18S rRNA dimethyltransferase\, and also with Nob1p\, which is involved in proteasome biogenesis; contains a KH domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIM2" EXACT []
synonym: "PNO1" EXACT []
synonym: "RRP20" EXACT []

[Term]
id: sgd:S000005672
name: YOR146W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005673
name: YOR147W
def: "Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1\, MDM10\, MDM12\, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM32" EXACT []

[Term]
id: sgd:S000005674
name: YOR148C
def: "Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation; interacts with Prp2p\, which may release Spp2p from the spliceosome following the first cleavage reaction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPP2" EXACT []

[Term]
id: sgd:S000005675
name: YOR149C
def: "Alpha 1\,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol \(GPI\) biosynthesis; required for addition of the fourth\, side branching mannose to the GPI core structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LAS2" EXACT []
synonym: "SAP2" EXACT []
synonym: "SMP3" EXACT []

[Term]
id: sgd:S000005676
name: YOR150W
def: "Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL23" EXACT []
synonym: "YmL23" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL23" EXACT []

[Term]
id: sgd:S000005677
name: YOR151C
def: "RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B150" EXACT []
synonym: "DNA-directed RNA polymerase II core subunit RPB2" EXACT []
synonym: "RPB150" EXACT []
synonym: "RPB2" EXACT []
synonym: "RPO22" EXACT []
synonym: "SIT2" EXACT []
synonym: "SOH2" EXACT []

[Term]
id: sgd:S000005678
name: YOR152C
def: "Putative protein of unknown function; YOR152C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005679
name: YOR153W
def: "Plasma membrane ATP-binding cassette \(ABC\) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport\, cation resistance\, and cellular detoxification during exponential growth; PDR5 has a paralog\, PDR15\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR5" EXACT []
synonym: "LEM1" EXACT []
synonym: "PDR5" EXACT []
synonym: "STS1" EXACT []
synonym: "YDR1" EXACT []

[Term]
id: sgd:S000005680
name: YOR154W
def: "Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLP1" EXACT []

[Term]
id: sgd:S000005681
name: YOR155C
def: "Inosine 5'-monophosphate \(IMP\)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IMP 5'-nucleotidase" EXACT []
synonym: "ISN1" EXACT []

[Term]
id: sgd:S000005682
name: YOR156C
def: "SUMO E3 ligase; catalyzes sumoylation of Yku70p/Yku80p and Sir4p promoting chromatin anchoring; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins\, enhancing interactions between these proteins and accelerating repair; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length; NFI1 has a paralog\, SIZ1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NFI1" EXACT []
synonym: "SIZ2" EXACT []
synonym: "SUMO ligase NFI1" EXACT []

[Term]
id: sgd:S000005683
name: YOR157C
def: "Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUP1" EXACT []
synonym: "proteasome core particle subunit beta 2" EXACT []

[Term]
id: sgd:S000005684
name: YOR158W
def: "Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122\, which encodes a COX3 mRNA-specific translational activator" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET123" EXACT []
synonym: "mitochondrial 37S ribosomal protein PET123" EXACT []

[Term]
id: sgd:S000005685
name: YOR159C
def: "Core Sm protein Sm E; part of heteroheptameric complex \(with Smb1p\, Smd1p\, Smd2p\, Smd3p\, Smx3p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm E" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SME1" EXACT []
synonym: "Sm E" EXACT []
synonym: "SmE" EXACT []

[Term]
id: sgd:S000005686
name: YOR160W
def: "Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP111" EXACT []
synonym: "MTR10" EXACT []

[Term]
id: sgd:S000005687
name: YOR161C
def: "Protein of unknown function; has similarity to Torpedo californica tCTL1p\, which is postulated to be a choline transporter\, neither null mutation nor overexpression affects choline transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PNS1" EXACT []

[Term]
id: sgd:S000005688
name: YOR162C
def: "Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p\, acting on an overlapping set of target genes; YRR1 has a paralog\, PDR8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDR2" EXACT []
synonym: "YRR1" EXACT []

[Term]
id: sgd:S000005689
name: YOR163W
def: "Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates\, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDP1" EXACT []
synonym: "polyphosphatase DDP1" EXACT []

[Term]
id: sgd:S000005690
name: YOR164C
def: "Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV8" EXACT []
synonym: "GET4" EXACT []

[Term]
id: sgd:S000005691
name: YOR165W
def: "Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1\, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEY1" EXACT []
synonym: "dynamin-like GTPase SEY1" EXACT []

[Term]
id: sgd:S000005692
name: YOR166C
def: "RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant\, unprocessed pre-mRNAs; interacts with subunits of THO/TREX\, TREX-2\, and RNA polymerase II; contains a PIN \(PilT N terminus\) domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWT1" EXACT []

[Term]
id: sgd:S000005693
name: YOR167C
def: "Protein component of the small \(40S\) ribosomal subunit; has an extraribosomal function in regulation of RPS28B\, in which Rps28Ap binds to a decapping complex via Edc3p\, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28\, no bacterial homolog; RPS28A has a paralog\, RPS28B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS28A" EXACT []
synonym: "RPS33A" EXACT []
synonym: "S28A" EXACT []
synonym: "S28e" EXACT []
synonym: "S33A" EXACT []
synonym: "YS27" EXACT []
synonym: "ribosomal 40S subunit protein S28A" EXACT []

[Term]
id: sgd:S000005694
name: YOR168W
def: "Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA\(Gln\); N-terminal domain proposed to be involved in enzyme-tRNA interactions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLN4" EXACT []
synonym: "glutamine--tRNA ligase" EXACT []

[Term]
id: sgd:S000005695
name: YOR169C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005696
name: YOR170W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005697
name: YOR171C
def: "Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates\, which function as signaling molecules\, regulates synthesis of ceramide from exogenous long-chain bases\, localizes to the Golgi and late endosomes; LCB4 has a paralog\, LCB5\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCB4" EXACT []
synonym: "sphinganine kinase LCB4" EXACT []

[Term]
id: sgd:S000005698
name: YOR172W
def: "Zinc finger transcription factor involved in multidrug resistance; Zn\(2\)-Cys\(6\) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p\, acting on an overlapping set of target genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YRM1" EXACT []

[Term]
id: sgd:S000005699
name: YOR173W
def: "m\(7\)GpppX pyrophosphatase regulator; non-essential\, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p\, Msn4p\, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog\, DCS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCS2" EXACT []

[Term]
id: sgd:S000005700
name: YOR174W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED4" EXACT []

[Term]
id: sgd:S000005701
name: YOR175C
def: "Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALE1" EXACT []
synonym: "LCA1" EXACT []
synonym: "LPT1" EXACT []
synonym: "SLC4" EXACT []

[Term]
id: sgd:S000005702
name: YOR176W
def: "Ferrochelatase; a mitochondrial inner membrane protein\, catalyzes the insertion of ferrous iron into protoporphyrin IX\, the eighth and final step in the heme biosynthetic pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM15" EXACT []
synonym: "ferrochelatase HEM15" EXACT []

[Term]
id: sgd:S000005703
name: YOR177C
def: "Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPC54" EXACT []

[Term]
id: sgd:S000005704
name: YOR178C
def: "Regulatory subunit for Glc7p type-1 protein phosphatase \(PP1\); tethers Glc7p to Gsy2p glycogen synthase\, binds Hsf1p heat shock transcription factor\, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog\, PIG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAC1" EXACT []
synonym: "protein phosphatase regulator GAC1" EXACT []

[Term]
id: sgd:S000005705
name: YOR179C
def: "Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog\, YSH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SYC1" EXACT []

[Term]
id: sgd:S000005706
name: YOR180C
def: "Peroxisomal protein; identification as a delta\(3\,5\)-delta\(2\,4\)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog\, ECI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DCI1" EXACT []
synonym: "ECI2" EXACT []
synonym: "putative dodecenoyl-CoA isomerase DCI1" EXACT []

[Term]
id: sgd:S000005707
name: YOR181W
def: "Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments and a polyproline domain which can nucleate actin filaments independent of Arp2/3; mutants are defective in actin cytoskeleton dependent processes such as\: endocytosis\, bud site selection and cytokinesis; localizes with the Arp2/3 complex to actin cortical patches; homolog of the Wiskott-Aldrich Syndrome protein \(WASP\)\, implicated in severe immunodeficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEE1" EXACT []
synonym: "LAS17" EXACT []

[Term]
id: sgd:S000005708
name: YOR182C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S30\, no bacterial homolog; RPS30B has a paralog\, RPS30A\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS30B" EXACT []
synonym: "S30B" EXACT []
synonym: "S30e" EXACT []
synonym: "ribosomal 40S subunit protein S30B" EXACT []

[Term]
id: sgd:S000005709
name: YOR183W
def: "Protein of unknown function; required for survival upon exposure to K1 killer toxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FYV12" EXACT []

[Term]
id: sgd:S000005710
name: YOR184W
def: "3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate\, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADE9" EXACT []
synonym: "O-phospho-L-serine:2-oxoglutarate transaminase" EXACT []
synonym: "SER1" EXACT []

[Term]
id: sgd:S000005711
name: YOR185C
def: "GTP binding protein \(mammalian Ranp homolog\); involved in the maintenance of nuclear organization\, RNA processing and transport; interacts with Kap121p\, Kap123p and Pdr6p \(karyophilin betas\); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog\, GSP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CNR2" EXACT []
synonym: "GSP2" EXACT []
synonym: "Ran GTPase GSP2" EXACT []

[Term]
id: sgd:S000005712
name: YOR186W
def: "Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog\, YLR297W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005713
name: YOR187W
def: "Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities\, while these activities are found in separate proteins in S. pombe and humans" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUF1" EXACT []
synonym: "translation elongation factor Tu" EXACT []
synonym: "tufM" EXACT []

[Term]
id: sgd:S000005714
name: YOR188W
def: "Protein of unknown function; may be involved in positive regulation of 1\,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42\, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSB1" EXACT []

[Term]
id: sgd:S000005715
name: YOR189W
def: "Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IES4" EXACT []

[Term]
id: sgd:S000005716
name: YOR190W
def: "Sporulation-specific exo-1\,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog\, EXG1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPR1" EXACT []
synonym: "SSG1" EXACT []

[Term]
id: sgd:S000005717
name: YOR191W
def: "Swi2/Snf2-related translocase\, SUMO-Targeted Ubiquitin Ligase \(STUbL\); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIS1" EXACT []
synonym: "RIS1" EXACT []
synonym: "TID4" EXACT []
synonym: "ULS1" EXACT []
synonym: "translocase ULS1" EXACT []

[Term]
id: sgd:S000005718
name: YOR192C
def: "Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside \(acadesine\); shares sequence similarity with Thi7p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI72" EXACT []

[Term]
id: sgd:S000005719
name: YOR193W
def: "Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number\, interacts with Pex25p; PEX27 has a paralog\, PEX25\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX27" EXACT []

[Term]
id: sgd:S000005720
name: YOR194C
def: "TFIIA large subunit; involved in transcriptional activation\, acts as antirepressor or as coactivator; required\, along with Toa2p\, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOA1" EXACT []

[Term]
id: sgd:S000005721
name: YOR195W
def: "Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network\, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLK19" EXACT []

[Term]
id: sgd:S000005722
name: YOR196C
def: "Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LIP5" EXACT []
synonym: "putative lipoate synthase" EXACT []

[Term]
id: sgd:S000005723
name: YOR197W
def: "Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases\, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Ca(2+)-dependent cysteine protease MCA1" EXACT []
synonym: "MCA1" EXACT []
synonym: "YCA1" EXACT []

[Term]
id: sgd:S000005724
name: YOR198C
def: "Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA \(Brefeldin A\) sensitivity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BFR1" EXACT []

[Term]
id: sgd:S000005725
name: YOR199W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005726
name: YOR200W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005727
name: YOR201C
def: "Ribose methyltransferase; modifies a functionally critical\, conserved nucleotide in mitochondrial 21S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRM1" EXACT []
synonym: "PET56" EXACT []

[Term]
id: sgd:S000005728
name: YOR202W
def: "Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu\, Co\, and Ni salts; transcription is regulated by general amino acid control via Gcn4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HIS10" EXACT []
synonym: "HIS3" EXACT []
synonym: "HIS8" EXACT []
synonym: "imidazoleglycerol-phosphate dehydratase HIS3" EXACT []

[Term]
id: sgd:S000005729
name: YOR203W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005730
name: YOR204W
def: "ATP-dependent DEAD \(Asp-Glu-Ala-Asp\)-box RNA helicase; required for translation initiation of all yeast mRNAs; binds to mRNA cap-associated factors\, and binding stimulates Ded1p RNA-dependent ATPase activity; mutation in human homolog DBY is associated with male infertility; human homolog DDX3X complements ded1 null mutation; DED1 has a paralog\, DBP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DEAD-box ATP-dependent RNA helicase DED1" EXACT []
synonym: "DED1" EXACT []
synonym: "SPP81" EXACT []

[Term]
id: sgd:S000005731
name: YOR205C
def: "Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin \(Phb1p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM40" EXACT []
synonym: "FMP38" EXACT []
synonym: "GEP3" EXACT []
synonym: "LRC5" EXACT []
synonym: "MTG3" EXACT []

[Term]
id: sgd:S000005732
name: YOR206W
def: "Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOC2" EXACT []

[Term]
id: sgd:S000005733
name: YOR207C
def: "Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes\, and other low molecular weight RNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "C128" EXACT []
synonym: "DNA-directed RNA polymerase III core subunit RET1" EXACT []
synonym: "PDS2" EXACT []
synonym: "RET1" EXACT []
synonym: "RPC128" EXACT []
synonym: "RPC2" EXACT []

[Term]
id: sgd:S000005734
name: YOR208W
def: "Nuclear phosphotyrosine-specific phosphatase involved in osmosensing; involved in the inactivation of mitogen-activated protein kinase \(MAPK\) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; with Msg5p co-regulates the calcium signaling pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTP2" EXACT []
synonym: "tyrosine protein phosphatase PTP2" EXACT []

[Term]
id: sgd:S000005735
name: YOR209C
def: "Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NPT1" EXACT []
synonym: "nicotinate phosphoribosyltransferase" EXACT []

[Term]
id: sgd:S000005736
name: YOR210W
def: "RNA polymerase subunit ABC10-beta; common to RNA polymerases I\, II\, and III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC10-beta" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPB10" EXACT []
synonym: "RPB10" EXACT []

[Term]
id: sgd:S000005737
name: YOR211C
def: "Mitochondrial GTPase\, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology\, fusion\, and genome maintenance; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGM1" EXACT []
synonym: "MNA1" EXACT []
synonym: "dynamin-related GTPase MGM1" EXACT []

[Term]
id: sgd:S000005738
name: YOR212W
def: "G protein beta subunit; forms a dimer with Ste18p to activate the mating signaling pathway\, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMD2" EXACT []
synonym: "STE4" EXACT []

[Term]
id: sgd:S000005739
name: YOR213C
def: "Subunit of the SAS complex \(Sas2p\, Sas4p\, Sas5p\); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAS5" EXACT []

[Term]
id: sgd:S000005740
name: YOR214C
def: "Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog\, SPO19\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPR2" EXACT []

[Term]
id: sgd:S000005741
name: YOR215C
def: "Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM41" EXACT []

[Term]
id: sgd:S000005742
name: YOR216C
def: "Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRP1" EXACT []
synonym: "RUD3" EXACT []

[Term]
id: sgd:S000005743
name: YOR217W
def: "Subunit of heteropentameric Replication factor C \(RF-C\); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen \(PCNA\) processivity factor for DNA polymerases delta and epsilon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC44" EXACT []
synonym: "RFC1" EXACT []
synonym: "replication factor C subunit 1" EXACT []

[Term]
id: sgd:S000005744
name: YOR218C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005745
name: YOR219C
def: "Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences\, required for maturation of alpha factor\, transcription is induced by a-factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "STE13" EXACT []
synonym: "YCI1" EXACT []

[Term]
id: sgd:S000005746
name: YOR220W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCN2" EXACT []
synonym: "WSP1" EXACT []

[Term]
id: sgd:S000005747
name: YOR221C
def: "Predicted malonyl-CoA\:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCT1" EXACT []
synonym: "[acyl-carrier-protein] S-malonyltransferase" EXACT []

[Term]
id: sgd:S000005748
name: YOR222W
def: "Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter\, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog\, ODC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ODC2" EXACT []

[Term]
id: sgd:S000005749
name: YOR223W
def: "Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSC3" EXACT []

[Term]
id: sgd:S000005750
name: YOR224C
def: "RNA polymerase subunit ABC14.5; common to RNA polymerases I\, II\, and III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC14.5" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPB8" EXACT []
synonym: "RPB8" EXACT []

[Term]
id: sgd:S000005751
name: YOR225W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005752
name: YOR226C
def: "Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved; ISU2 has a paralog\, ISU1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISU2" EXACT []
synonym: "NUA2" EXACT []
synonym: "putative iron-binding protein ISU2" EXACT []

[Term]
id: sgd:S000005753
name: YOR227W
def: "Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes\, based on co-purification experiments; HER1 has a paralog\, GIP3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HER1" EXACT []

[Term]
id: sgd:S000005754
name: YOR228C
def: "Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10\, and other members of the ERMES complex; contains five predicted transmembrane domains" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCP1" EXACT []

[Term]
id: sgd:S000005755
name: YOR229W
def: "Transcriptional modulator; involved in regulation of meiosis\, silencing\, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog\, UME1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WTM2" EXACT []

[Term]
id: sgd:S000005756
name: YOR230W
def: "Transcriptional modulator; involved in regulation of meiosis\, silencing\, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WTM1" EXACT []

[Term]
id: sgd:S000005757
name: YOR231W
def: "MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target\, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog\, MKK2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MKK1" EXACT []
synonym: "SSP32" EXACT []
synonym: "mitogen-activated protein kinase kinase MKK1" EXACT []

[Term]
id: sgd:S000005758
name: YOR232W
def: "Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress\, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 \(GRPEL1\)\, which also responds to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRPE" EXACT []
synonym: "MGE1" EXACT []
synonym: "YGE1" EXACT []

[Term]
id: sgd:S000005759
name: YOR233W
def: "Serine/threonine protein kinase; inhibits the mitotic exit network \(MEN\) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex\, spindle pole body and bud neck; KIN4 has a paralog\, FRK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIN3" EXACT []
synonym: "KIN31" EXACT []
synonym: "KIN4" EXACT []
synonym: "putative serine/threonine protein kinase KIN4" EXACT []

[Term]
id: sgd:S000005760
name: YOR234C
def: "Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A\, no bacterial homolog; RPL33B has a paralog\, RPL33A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L33B" EXACT []
synonym: "L33e" EXACT []
synonym: "L37B" EXACT []
synonym: "RPL33B" EXACT []
synonym: "RPL37B" EXACT []
synonym: "Yl37" EXACT []
synonym: "ribosomal 60S subunit protein L33B" EXACT []
synonym: "rp47" EXACT []

[Term]
id: sgd:S000005761
name: YOR235W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC13" EXACT []

[Term]
id: sgd:S000005762
name: YOR236W
def: "Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DFR1" EXACT []
synonym: "dihydrofolate reductase" EXACT []

[Term]
id: sgd:S000005763
name: YOR237W
def: "Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein \(OSBP\); HES1 has a paralog\, KES1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HES1" EXACT []
synonym: "OSH5" EXACT []
synonym: "oxysterol-binding protein related protein HES1" EXACT []

[Term]
id: sgd:S000005764
name: YOR238W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005765
name: YOR239W
def: "AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine \(AdoMet\) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABP140" EXACT []
synonym: "TRM140" EXACT []
synonym: "YOR240W" EXACT []

[Term]
id: sgd:S000005767
name: YOR241W
def: "Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes\, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET23" EXACT []
synonym: "MET7" EXACT []
synonym: "tetrahydrofolate synthase" EXACT []

[Term]
id: sgd:S000005768
name: YOR242C
def: "Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed\, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSP2" EXACT []

[Term]
id: sgd:S000005769
name: YOR243C
def: "Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA\, position 50 in 5S rRNA\, position 13 in cytoplasmic tRNAs\, and position 35 in pre-tRNA\(Tyr\); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea\, vertebrates\, and some bacteria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS7" EXACT []
synonym: "pseudouridine synthase PUS7" EXACT []

[Term]
id: sgd:S000005770
name: YOR244W
def: "Catalytic subunit of the histone acetyltransferase complex \(NuA4\); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESA1" EXACT []
synonym: "KAT5" EXACT []
synonym: "NuA4 histone acetyltransferase complex catalytic subunit ESA1" EXACT []
synonym: "TAS1" EXACT []

[Term]
id: sgd:S000005771
name: YOR245C
def: "Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol \(TAG\) formation\, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DGA1" EXACT []
synonym: "diacylglycerol O-acyltransferase" EXACT []

[Term]
id: sgd:S000005772
name: YOR246C
def: "Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases\, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae\, a model system for studying replication of positive-strand RNA viruses in their natural hosts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV9" EXACT []

[Term]
id: sgd:S000005773
name: YOR247W
def: "Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog\, SVS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRL1" EXACT []

[Term]
id: sgd:S000005774
name: YOR248W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TOS11" EXACT []

[Term]
id: sgd:S000005775
name: YOR249C
def: "Subunit of the Anaphase-Promoting Complex/Cyclosome \(APC/C\); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors\, including mitotic cyclins\, during the metaphase/anaphase transition; component of the platform domain of the APC/C\, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APC5" EXACT []
synonym: "RMC1" EXACT []
synonym: "anaphase promoting complex subunit 5" EXACT []

[Term]
id: sgd:S000005776
name: YOR250C
def: "Component of the cleavage and polyadenylation factor I \(CF I\); CF 1\, composed of the CF 1A complex \(Rna14p\, Rna15p\, Clp1p\, Pcf11p\) and Hrp1\, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLP1" EXACT []

[Term]
id: sgd:S000005777
name: YOR251C
def: "Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TUM1" EXACT []

[Term]
id: sgd:S000005778
name: YOR252W
def: "Protein of unknown function that associates with ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF17" EXACT []
synonym: "TMA16" EXACT []

[Term]
id: sgd:S000005779
name: YOR253W
def: "Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p\, Ard1p\, and Nat5p; N-terminally acetylates many proteins\, which influences multiple processes such as the cell cycle\, heat-shock resistance\, mating\, sporulation\, and telomeric silencing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARD2" EXACT []
synonym: "NAA50" EXACT []
synonym: "NAT5" EXACT []
synonym: "ROG2" EXACT []

[Term]
id: sgd:S000005780
name: YOR254C
def: "Essential subunit of Sec63 complex; with Sec61 complex\, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p\, Sec66p\, and Sec72p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PTL1" EXACT []
synonym: "SEC63" EXACT []
synonym: "protein-transporting protein SEC63" EXACT []

[Term]
id: sgd:S000005781
name: YOR255W
def: "Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSW1" EXACT []

[Term]
id: sgd:S000005782
name: YOR256C
def: "Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog\, TRE1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRE2" EXACT []

[Term]
id: sgd:S000005783
name: YOR257W
def: "Calcium-binding component of the spindle pole body \(SPB\) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC31" EXACT []
synonym: "DSK1" EXACT []
synonym: "centrin" EXACT []

[Term]
id: sgd:S000005784
name: YOR258W
def: "DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad \(HIT\) superfamily of nucleotide-binding proteins; homolog of Aprataxin\, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HNT3" EXACT []

[Term]
id: sgd:S000005785
name: YOR259C
def: "ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CRL13" EXACT []
synonym: "PCS1" EXACT []
synonym: "RPT4" EXACT []
synonym: "SUG2" EXACT []
synonym: "proteasome regulatory particle base subunit RPT4" EXACT []

[Term]
id: sgd:S000005786
name: YOR260W
def: "Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCD1" EXACT []
synonym: "TRA3" EXACT []

[Term]
id: sgd:S000005787
name: YOR261C
def: "Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit\, Rpn11p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN8" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN8" EXACT []

[Term]
id: sgd:S000005788
name: YOR262W
def: "Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPN2" EXACT []

[Term]
id: sgd:S000005789
name: YOR263C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005790
name: YOR264W
def: "Daughter cell-specific protein\, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSE3" EXACT []

[Term]
id: sgd:S000005791
name: YOR265W
def: "Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBL2" EXACT []

[Term]
id: sgd:S000005792
name: YOR266W
def: "Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p\, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PNT1" EXACT []

[Term]
id: sgd:S000005793
name: YOR267C
def: "Protein kinase; implicated in activation of the plasma membrane H\(+\)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRK1" EXACT []
synonym: "putative serine/threonine protein kinase HRK1" EXACT []

[Term]
id: sgd:S000005794
name: YOR268C
def: "Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005795
name: YOR269W
def: "Involved in nuclear migration\, part of the dynein/dynactin pathway; targets dynein to microtubule tips\, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk\, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1\, mutations in which cause the severe brain disorder lissencephaly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAC1" EXACT []

[Term]
id: sgd:S000005796
name: YOR270C
def: "Subunit a of vacuolar-ATPase V0 domain; one of two isoforms \(Vph1p and Stv1p\); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V0 sector ATPase subunit a" EXACT []
synonym: "VPH1" EXACT []

[Term]
id: sgd:S000005797
name: YOR271C
def: "Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FSF1" EXACT []

[Term]
id: sgd:S000005798
name: YOR272W
def: "Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST14" EXACT []
synonym: "YTM1" EXACT []

[Term]
id: sgd:S000005799
name: YOR273C
def: "Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; recognizes spermine\, putrescine\, and spermidine; localizes to the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPO4" EXACT []

[Term]
id: sgd:S000005800
name: YOR274W
def: "Delta 2-isopentenyl pyrophosphate\:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form\, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1\, a mutation in which is associated with severe combined respiratory chain defects" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOD5" EXACT []
synonym: "[MOD+]" EXACT []

[Term]
id: sgd:S000005801
name: YOR275C
def: "Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM20" EXACT []

[Term]
id: sgd:S000005802
name: YOR276W
def: "Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translation initiation; competes with eIF4G for binding to eIF4E" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAF2" EXACT []
synonym: "CAF20" EXACT []
synonym: "CAP20" EXACT []
synonym: "p20" EXACT []

[Term]
id: sgd:S000005803
name: YOR277C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005804
name: YOR278W
def: "Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III\, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HEM4" EXACT []
synonym: "SLU2" EXACT []
synonym: "uroporphyrinogen-III synthase HEM4" EXACT []

[Term]
id: sgd:S000005805
name: YOR279C
def: "Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RFM1" EXACT []

[Term]
id: sgd:S000005806
name: YOR280C
def: "Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FSH3" EXACT []

[Term]
id: sgd:S000005807
name: YOR281C
def: "Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLP2" EXACT []

[Term]
id: sgd:S000005808
name: YOR282W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps essential\, verified gene PLP2/YOR281C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005809
name: YOR283W
def: "Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C\, a phosphoglycerate mutase; YOR283W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "phosphoglycerate mutase" EXACT []

[Term]
id: sgd:S000005810
name: YOR284W
def: "Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUA2" EXACT []

[Term]
id: sgd:S000005811
name: YOR285W
def: "Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDL1" EXACT []

[Term]
id: sgd:S000005812
name: YOR286W
def: "Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p\, Uba4p\, Tum1p\, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM42" EXACT []
synonym: "FMP31" EXACT []
synonym: "RDL2" EXACT []

[Term]
id: sgd:S000005813
name: YOR287C
def: "Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP36" EXACT []

[Term]
id: sgd:S000005814
name: YOR288C
def: "Member of the protein disulfide isomerase \(PDI\) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MPD1" EXACT []
synonym: "protein disulfide isomerase MPD1" EXACT []

[Term]
id: sgd:S000005815
name: YOR289W
def: "Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005816
name: YOR290C
def: "Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAM1" EXACT []
synonym: "HAF1" EXACT []
synonym: "SNF2" EXACT []
synonym: "SWI/SNF catalytic subunit SNF2" EXACT []
synonym: "SWI2" EXACT []
synonym: "TYE3" EXACT []

[Term]
id: sgd:S000005817
name: YOR291W
def: "Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 \(PARK9\)\, mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPK9" EXACT []

[Term]
id: sgd:S000005818
name: YOR292C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the vacuole; YOR292C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005819
name: YOR293W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S10\, no bacterial homolog; RPS10A has a paralog\, RPS10B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS10A" EXACT []
synonym: "S10A" EXACT []
synonym: "S10e" EXACT []
synonym: "ribosomal 40S subunit protein S10A" EXACT []

[Term]
id: sgd:S000005820
name: YOR294W
def: "Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p\, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRS1" EXACT []

[Term]
id: sgd:S000005821
name: YOR295W
def: "Subunit of UAF \(upstream activation factor\) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p\, Rrn5p\, Rrn9p\, Rrn10p\, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog\, TRI1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UAF30" EXACT []

[Term]
id: sgd:S000005822
name: YOR296W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005823
name: YOR297C
def: "Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM18" EXACT []

[Term]
id: sgd:S000005824
name: YOR298W
def: "Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUM3" EXACT []

[Term]
id: sgd:S000005825
name: YOR299W
def: "Member of the ChAPs family \(Chs5p-Arf1p-binding proteins\); members include Bch1p\, Bch2p\, Bud7p\, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins\, including Chs3p\, from the Golgi to the plasma membrane; BUD7 has a paralog\, BCH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD7" EXACT []

[Term]
id: sgd:S000005826
name: YOR300W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection\, though phenotype could be due to the mutation's effects on BUD7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUF1" EXACT []

[Term]
id: sgd:S000005827
name: YOR301W
def: "Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAX1" EXACT []

[Term]
id: sgd:S000005828
name: YOR302W
def: "CPA1 uORF; Arginine attenuator peptide\, regulates translation of the CPA1 mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005829
name: YOR303W
def: "Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline\, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPA1" EXACT []
synonym: "carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1" EXACT []

[Term]
id: sgd:S000005830
name: YOR304C-A
def: "Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BIL1" EXACT []
synonym: "EDO1" EXACT []

[Term]
id: sgd:S000005831
name: YOR304W
def: "ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that\, with Itc1p\, forms a complex required for repression of a-specific genes\, INO1\, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISW2" EXACT []

[Term]
id: sgd:S000005832
name: YOR305W
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-\(N-\(S-glutathionylacetyl\)amino\) phenylarsenoxide \(GSAO\); YOR305W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRG7" EXACT []

[Term]
id: sgd:S000005833
name: YOR306C
def: "Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases\, however mutants are not deficient in monocarboxylate transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCH5" EXACT []

[Term]
id: sgd:S000005834
name: YOR307C
def: "Protein involved in ER-to-Golgi transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLY41" EXACT []

[Term]
id: sgd:S000005835
name: YOR308C
def: "Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNU66" EXACT []

[Term]
id: sgd:S000005836
name: YOR309C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005837
name: YOR310C
def: "Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing\, 18S rRNA synthesis\, and snoRNA synthesis; component of the small subunit processome complex\, which is required for processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP5" EXACT []
synonym: "NOP58" EXACT []
synonym: "RNA-processing protein NOP58" EXACT []

[Term]
id: sgd:S000005838
name: YOR311C
def: "Diacylglycerol kinase; localized to the endoplasmic reticulum \(ER\); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DGK1" EXACT []
synonym: "HSD1" EXACT []

[Term]
id: sgd:S000005839
name: YOR312C
def: "Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A\, no bacterial homolog; RPL20B has a paralog\, RPL20A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L18B" EXACT []
synonym: "L20B" EXACT []
synonym: "L20e" EXACT []
synonym: "RPL18A1" EXACT []
synonym: "RPL20B" EXACT []
synonym: "ribosomal 60S subunit protein L20B" EXACT []

[Term]
id: sgd:S000005840
name: YOR313C
def: "Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPS4" EXACT []

[Term]
id: sgd:S000005841
name: YOR314W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005842
name: YOR315W
def: "Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae \(which do not invade the agar substrate\) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SFG1" EXACT []

[Term]
id: sgd:S000005843
name: YOR316C
def: "Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog\, ZRC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COT1" EXACT []
synonym: "metal cation transporter COT1" EXACT []

[Term]
id: sgd:S000005844
name: YOR317W
def: "Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12\:0-C16\:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog\, FAA4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAA1" EXACT []
synonym: "long-chain fatty acid-CoA ligase FAA1" EXACT []

[Term]
id: sgd:S000005845
name: YOR318C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005846
name: YOR319W
def: "U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs \(RRM\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSH49" EXACT []

[Term]
id: sgd:S000005847
name: YOR320C
def: "N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GNT1" EXACT []

[Term]
id: sgd:S000005848
name: YOR321W
def: "Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p\, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog\, PMT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PMT3" EXACT []
synonym: "dolichyl-phosphate-mannose-protein mannosyltransferase PMT3" EXACT []

[Term]
id: sgd:S000005849
name: YOR322C
def: "Alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its targets; involved in the basal internalization and turnover of alpha-factor receptor Ste2p; recruits ubiquitin ligase Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation\, which affects translocation between the cytosol and the plasma membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART1" EXACT []
synonym: "LDB19" EXACT []

[Term]
id: sgd:S000005850
name: YOR323C
def: "Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRO2" EXACT []
synonym: "glutamate-5-semialdehyde dehydrogenase" EXACT []

[Term]
id: sgd:S000005851
name: YOR324C
def: "Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions\, possibly via a role in posttranslational translocation; FRT1 has a paralog\, FRT2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRT1" EXACT []
synonym: "HPH1" EXACT []

[Term]
id: sgd:S000005852
name: YOR325W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005853
name: YOR326W
def: "Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles\, the vacuole\, late Golgi elements\, peroxisomes\, and the mitotic spindle; MYO2 has a paralog\, MYO4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC66" EXACT []
synonym: "MYO2" EXACT []
synonym: "myosin 2" EXACT []

[Term]
id: sgd:S000005854
name: YOR327C
def: "Vesicle membrane receptor protein \(v-SNARE\); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog\, SNC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNAP receptor SNC2" EXACT []
synonym: "SNC2" EXACT []

[Term]
id: sgd:S000005855
name: YOR328W
def: "ATP-binding cassette \(ABC\) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR10" EXACT []
synonym: "PDR10" EXACT []

[Term]
id: sgd:S000005856
name: YOR329C
def: "Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FTB1" EXACT []
synonym: "SCD5" EXACT []
synonym: "SCD7" EXACT []

[Term]
id: sgd:S000005857
name: YOR330C
def: "Mitochondrial DNA polymerase gamma subunit; conserved C-terminal segment is required for the maintenance of mitochondrial genome; its human ortholog\, POLG\, can rescue mip1 phenotypes\, and mutations in POLG are associated with Alpers-Huttenlocher syndrome \(AHS\) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast\, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-directed DNA polymerase gamma MIP1" EXACT []
synonym: "MIP1" EXACT []

[Term]
id: sgd:S000005858
name: YOR331C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005859
name: YOR332W
def: "Subunit E of the V1 domain of the vacuolar H+-ATPase \(V-ATPase\); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-transporting V1 sector ATPase subunit E" EXACT []
synonym: "VMA4" EXACT []

[Term]
id: sgd:S000005860
name: YOR333C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps 5' end of MRS2 gene required for respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SWF5" EXACT []

[Term]
id: sgd:S000005861
name: YOR334W
def: "Mitochondrial inner membrane Mg\(2+\) channel; required for maintenance of intramitochondrial Mg\(2+\) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS2" EXACT []

[Term]
id: sgd:S000005862
name: YOR335C
def: "Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation \(cdc64-1 allele\) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALA1" EXACT []
synonym: "CDC64" EXACT []
synonym: "alanine--tRNA ligase" EXACT []

[Term]
id: sgd:S000005863
name: YOR336W
def: "Protein required for beta-1\,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KRE5" EXACT []

[Term]
id: sgd:S000005864
name: YOR337W
def: "Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TEA1" EXACT []

[Term]
id: sgd:S000005865
name: YOR338W
def: "Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog\, FUN19\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005866
name: YOR339C
def: "Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C\, but not a true functional homolog of this E2; unlike E2-C\, not required for the degradation of mitotic cyclin Clb2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBC11" EXACT []
synonym: "putative E2 ubiquitin-protein ligase UBC11" EXACT []

[Term]
id: sgd:S000005867
name: YOR340C
def: "RNA polymerase I subunit A43" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A43" EXACT []
synonym: "DNA-directed RNA polymerase I subunit RPA43" EXACT []
synonym: "RPA43" EXACT []

[Term]
id: sgd:S000005868
name: YOR341W
def: "RNA polymerase I largest subunit A190" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A190" EXACT []
synonym: "DNA-directed RNA polymerase I core subunit RPA190" EXACT []
synonym: "RPA190" EXACT []
synonym: "RRN1" EXACT []

[Term]
id: sgd:S000005869
name: YOR342C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog\, YAL037W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005870
name: YOR343C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005871
name: YOR344C
def: "Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGC1" EXACT []
synonym: "TYE7" EXACT []

[Term]
id: sgd:S000005872
name: YOR345C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin\, cycloheximide and H2O2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005873
name: YOR346W
def: "Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis \(TLS\); forms a complex with the subunits of DNA polymerase zeta\, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REV1" EXACT []

[Term]
id: sgd:S000005874
name: YOR347C
def: "Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose\, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog\, CDC19\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PYK2" EXACT []
synonym: "pyruvate kinase PYK2" EXACT []

[Term]
id: sgd:S000005875
name: YOR348C
def: "Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate \(AzC\); PUT4 transcription is repressed in ammonia-grown cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUT4" EXACT []
synonym: "proline permease PUT4" EXACT []

[Term]
id: sgd:S000005876
name: YOR349W
def: "Tubulin folding factor D involved in beta-tubulin \(Tub2p\) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIN1" EXACT []

[Term]
id: sgd:S000005877
name: YOR350C
def: "Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNE1" EXACT []

[Term]
id: sgd:S000005878
name: YOR351C
def: "Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint\, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEK1" EXACT []
synonym: "MRE4" EXACT []
synonym: "serine/threonine protein kinase MEK1" EXACT []

[Term]
id: sgd:S000005879
name: YOR352W
def: "Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5\,6p; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFB6" EXACT []
synonym: "TFIIH complex subunit TFB6" EXACT []

[Term]
id: sgd:S000005880
name: YOR353C
def: "Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOG2" EXACT []

[Term]
id: sgd:S000005881
name: YOR354C
def: "Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSC6" EXACT []

[Term]
id: sgd:S000005882
name: YOR355W
def: "Protein of unknown function; required for growth on glycerol as a carbon source; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDS1" EXACT []

[Term]
id: sgd:S000005883
name: YOR356W
def: "Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIR2" EXACT []

[Term]
id: sgd:S000005884
name: YOR357C
def: "Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRD19" EXACT []
synonym: "SNX3" EXACT []

[Term]
id: sgd:S000005885
name: YOR358W
def: "Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAP5" EXACT []

[Term]
id: sgd:S000005886
name: YOR359W
def: "Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug \(Smg\) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif \(SAM\) domain that interacts with Smg recognition element \(SREs\) containing transcripts; stimulates Dna2p endonuclease activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VTS1" EXACT []

[Term]
id: sgd:S000005887
name: YOR360C
def: "High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system\, protects the cell from extracellular cAMP\, contains readthrough motif surrounding termination codon" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "3'" EXACT []
synonym: "5'-cyclic-nucleotide phosphodiesterase PDE2" EXACT []
synonym: "PDE2" EXACT []
synonym: "SRA5" EXACT []

[Term]
id: sgd:S000005888
name: YOR361C
def: "eIF3b subunit of the eukaryotic translation initiation factor 3 \(eIF3\); subunit of the core complex of eIF3; essential for translation; part of a subcomplex \(Prt1p-Rpg1p-Nip1p\) that stimulates binding of mRNA and tRNA\(i\)Met to ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC63" EXACT []
synonym: "DNA26" EXACT []
synonym: "PRT1" EXACT []

[Term]
id: sgd:S000005889
name: YOR362C
def: "Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRE10" EXACT []
synonym: "proteasome core particle subunit alpha 7" EXACT []

[Term]
id: sgd:S000005890
name: YOR363C
def: "Autoregulatory\, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p\, which binds to oleate-response elements \(ORE\) in the promoter of genes involved in beta-oxidation of fatty acids\, peroxisome organization and biogenesis\, activating transcription in the presence of oleate; PIP2 has a paralog\, OAF1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OAF2" EXACT []
synonym: "PIP2" EXACT []
synonym: "oleate-activated transcription factor PIP2" EXACT []

[Term]
id: sgd:S000005891
name: YOR364W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005892
name: YOR365C
def: "Putative protein of unknown function; not an essential protein; YOR365C has a paralog\, FLC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative FAD transporter" EXACT []

[Term]
id: sgd:S000005893
name: YOR366W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005894
name: YOR367W
def: "Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin \(contains a calponin-like repeat\) but the Scp1p domain structure is more similar to transgelin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCP1" EXACT []

[Term]
id: sgd:S000005895
name: YOR368W
def: "Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p\, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RAD17" EXACT []

[Term]
id: sgd:S000005896
name: YOR369C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S12\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS12" EXACT []
synonym: "S12" EXACT []
synonym: "S12e" EXACT []
synonym: "ribosomal 40S subunit protein S12" EXACT []

[Term]
id: sgd:S000005897
name: YOR370C
def: "Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II \(Bet2p-Bet4p\); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS6" EXACT []
synonym: "MSI4" EXACT []

[Term]
id: sgd:S000005898
name: YOR371C
def: "Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p\, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog\, GPB2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPB1" EXACT []
synonym: "KRH2" EXACT []

[Term]
id: sgd:S000005899
name: YOR372C
def: "Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NDD1" EXACT []

[Term]
id: sgd:S000005900
name: YOR373W
def: "Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NUD1" EXACT []

[Term]
id: sgd:S000005901
name: YOR374W
def: "Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALD4" EXACT []
synonym: "ALD7" EXACT []
synonym: "ALDH2" EXACT []
synonym: "aldehyde dehydrogenase (NADP(+)) ALD4" EXACT []

[Term]
id: sgd:S000005902
name: YOR375C
def: "NADP\(+\)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog\, GDH3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DHE4" EXACT []
synonym: "GDH-A" EXACT []
synonym: "GDH1" EXACT []
synonym: "GDHA" EXACT []
synonym: "URE1" EXACT []
synonym: "glutamate dehydrogenase (NADP(+)) GDH1" EXACT []

[Term]
id: sgd:S000005903
name: YOR376W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YOR376W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005904
name: YOR377W
def: "Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATF1" EXACT []

[Term]
id: sgd:S000005905
name: YOR378W
def: "Low affinity NH4+ transporter; member of the DHA2 family of drug\:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AMF1" EXACT []

[Term]
id: sgd:S000005906
name: YOR379C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005907
name: YOR380W
def: "Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDR1" EXACT []

[Term]
id: sgd:S000005908
name: YOR381W
def: "Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE3" EXACT []

[Term]
id: sgd:S000005909
name: YOR382W
def: "Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol \(GPI\) anchor; involved in the retention of siderophore-iron in the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIT2" EXACT []

[Term]
id: sgd:S000005910
name: YOR383C
def: "Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol \(GPI\) anchor; involved in the retention of siderophore-iron in the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FIT3" EXACT []

[Term]
id: sgd:S000005911
name: YOR384W
def: "Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRE5" EXACT []

[Term]
id: sgd:S000005912
name: YOR385W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005913
name: YOR386W
def: "DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHR1" EXACT []
synonym: "deoxyribodipyrimidine photo-lyase PHR1" EXACT []

[Term]
id: sgd:S000005914
name: YOR387C
def: "Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; YOR387C has a paralog\, VEL1\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005915
name: YOR388C
def: "NAD\(+\)-dependent formate dehydrogenase; may protect cells from exogenous formate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FDH1" EXACT []
synonym: "formate dehydrogenase (NAD+)" EXACT []

[Term]
id: sgd:S000005916
name: YOR389W
def: "Putative protein of unknown function; expression regulated by copper levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005917
name: YOR390W
def: "Protein involved in fluoride export; nearly identical to FEX2\, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FEX1" EXACT []

[Term]
id: sgd:S000005918
name: YOR391C
def: "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p\, Hsp32p\, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily\, which includes human DJ-1 involved in Parkinson's disease and cancer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP33" EXACT []

[Term]
id: sgd:S000005919
name: YOR392W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; gene expression induced by heat" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005920
name: YOR393W
def: "Protein of unknown function; has similarity to enolases" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERR1" EXACT []
synonym: "phosphopyruvate hydratase ERR1" EXACT []

[Term]
id: sgd:S000005921
name: YOR394W
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau22p; encodes 2 proteins that are translated from 2 different start codons" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU21" EXACT []
synonym: "seripauperin PAU21" EXACT []

[Term]
id: sgd:S000005922
name: YPL001W
def: "Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAT1" EXACT []
synonym: "KAT1" EXACT []

[Term]
id: sgd:S000005923
name: YPL002C
def: "Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-II subunit protein SNF8" EXACT []
synonym: "SNF8" EXACT []
synonym: "VPL14" EXACT []
synonym: "VPS22" EXACT []

[Term]
id: sgd:S000005924
name: YPL003W
def: "Protein that activates Rub1p \(NEDD8\) before neddylation; acts together with Uba3p; may play a role in protein degradation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENR2" EXACT []
synonym: "ULA1" EXACT []

[Term]
id: sgd:S000005925
name: YPL004C
def: "Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSP1" EXACT []
synonym: "lipid-binding protein LSP1" EXACT []

[Term]
id: sgd:S000005926
name: YPL005W
def: "Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AEP3" EXACT []

[Term]
id: sgd:S000005927
name: YPL006W
def: "Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway\, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases \(LCB\)\, similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C\, a disease caused by loss-of-function mutations in NPC1\, the functional ortholog of Ncr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCR1" EXACT []

[Term]
id: sgd:S000005928
name: YPL007C
def: "Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex \(TFIIIC\); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFC8" EXACT []
synonym: "tau 60" EXACT []
synonym: "transcription factor TFIIIC subunit TFC8" EXACT []

[Term]
id: sgd:S000005929
name: YPL008W
def: "Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing\, rDNA recombination\, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog\, DDX11/ChLR1\, cause Warsaw breakage syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL1" EXACT []
synonym: "CTF1" EXACT []
synonym: "LPA9" EXACT []
synonym: "MCM12" EXACT []

[Term]
id: sgd:S000005930
name: YPL009C
def: "Component of RQC\, which mediates nascent chain degradation; RQC \(ribosome quality control complex\) is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RQC2" EXACT []
synonym: "TAE2" EXACT []

[Term]
id: sgd:S000005931
name: YPL010W
def: "Zeta subunit of the coatomer complex \(COPI\); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RET3" EXACT []

[Term]
id: sgd:S000005932
name: YPL011C
def: "TFIID subunit \(47 kDa\); involved in promoter binding and RNA polymerase II transcription initiation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAF3" EXACT []
synonym: "TAF47" EXACT []
synonym: "TafII47" EXACT []

[Term]
id: sgd:S000005933
name: YPL012W
def: "Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP12" EXACT []

[Term]
id: sgd:S000005934
name: YPL013C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPS16" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRPS16" EXACT []

[Term]
id: sgd:S000005935
name: YPL014W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and to the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005936
name: YPL015C
def: "Cytoplasmic NAD\(+\)-dependent protein deacetylase; member of the silencing information regulator 2 \(Sir2\) family of NAD\(+\)-dependent protein deacetylases; modulates nucleolar \(rDNA\) and telomeric silencing; possesses NAD\(+\)-dependent histone deacetylase activity in vitro; contains a nuclear export signal \(NES\); function regulated by its nuclear export" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HST2" EXACT []
synonym: "histone deacetylase HST2" EXACT []

[Term]
id: sgd:S000005937
name: YPL016W
def: "Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes\, including ADH1\, ADH2\, GAL1\, HO\, INO1 and SUC2; can form the prion \[SWI+\]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADR6" EXACT []
synonym: "GAM3" EXACT []
synonym: "LPA1" EXACT []
synonym: "SWI1" EXACT []
synonym: "[SWI(+)]" EXACT []
synonym: "[SWI+]" EXACT []

[Term]
id: sgd:S000005938
name: YPL017C
def: "Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression\, increased levels of spontaneous Rad52 foci; IRC15 has a paralog\, LPD1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC15" EXACT []

[Term]
id: sgd:S000005939
name: YPL018W
def: "Outer kinetochore protein\, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA \(Ctf19p\, Okp1p\, Mcm21p\, Ame1p\) that functions as a platform for kinetochore assembly; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-P and fission yeast fta2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTF19" EXACT []
synonym: "MCM18" EXACT []

[Term]
id: sgd:S000005940
name: YPL019C
def: "Subunit of vacuolar transporter chaperone \(VTC\) complex; involved in membrane trafficking\, vacuolar polyphosphate accumulation\, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog\, VTC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PHM2" EXACT []
synonym: "VTC3" EXACT []

[Term]
id: sgd:S000005941
name: YPL020C
def: "Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIB1" EXACT []
synonym: "SUMO protease ULP1" EXACT []
synonym: "ULP1" EXACT []

[Term]
id: sgd:S000005942
name: YPL021W
def: "Non-essential protein of unconfirmed function; affects pre-rRNA processing\, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ECM23" EXACT []
synonym: "SRD2" EXACT []

[Term]
id: sgd:S000005943
name: YPL022W
def: "Single-stranded DNA endonuclease \(with Rad10p\); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 \(NEF1\); homolog of human XPF protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPB9" EXACT []
synonym: "RAD1" EXACT []
synonym: "ssDNA endodeoxyribonuclease RAD1" EXACT []

[Term]
id: sgd:S000005944
name: YPL023C
def: "Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase \(MTHFR\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET12" EXACT []
synonym: "methylenetetrahydrofolate reductase (NAD(P)H) MET12" EXACT []

[Term]
id: sgd:S000005945
name: YPL024W
def: "Subunit of the RecQ \(Sgs1p\) - Topo III \(Top3p\) complex; stimulates superhelical relaxing\, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCE4" EXACT []
synonym: "RMI1" EXACT []

[Term]
id: sgd:S000005946
name: YPL025C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005947
name: YPL026C
def: "Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog\, VHS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SHA3" EXACT []
synonym: "SKS1" EXACT []
synonym: "putative serine/threonine protein kinase SKS1" EXACT []

[Term]
id: sgd:S000005948
name: YPL027W
def: "Protein of unknown function involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMA1" EXACT []

[Term]
id: sgd:S000005949
name: YPL028W
def: "Acetyl-CoA C-acetyltransferase \(acetoacetyl-CoA thiolase\); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another\, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERG10" EXACT []
synonym: "LPB3" EXACT []
synonym: "TSM0115" EXACT []
synonym: "acetyl-CoA C-acetyltransferase" EXACT []

[Term]
id: sgd:S000005950
name: YPL029W
def: "ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPB2" EXACT []
synonym: "SUV3" EXACT []

[Term]
id: sgd:S000005951
name: YPL030W
def: "tRNA\(Ser\) Um\(44\) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS\(CGA\) and tS\(UGA\); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRM44" EXACT []

[Term]
id: sgd:S000005952
name: YPL031C
def: "Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LDB15" EXACT []
synonym: "PHO85" EXACT []
synonym: "cyclin-dependent serine/threonine-protein kinase PHO85" EXACT []
synonym: "phoU" EXACT []

[Term]
id: sgd:S000005953
name: YPL032C
def: "Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery\, cytoplasm\, bud\, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog\, PAM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SVL3" EXACT []

[Term]
id: sgd:S000005954
name: YPL033C
def: "Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRL4" EXACT []

[Term]
id: sgd:S000005955
name: YPL034W
def: "Putative protein of unknown function; YPL034W is not essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005956
name: YPL035C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005957
name: YPL036W
def: "Plasma membrane H+-ATPase; isoform of Pma1p\, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "H(+)-exporting P2-type ATPase PMA2" EXACT []
synonym: "PMA2" EXACT []

[Term]
id: sgd:S000005958
name: YPL037C
def: "Subunit beta1 of the nascent polypeptide-associated complex \(NAC\); involved in protein targeting\, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog\, BTT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EGD1" EXACT []

[Term]
id: sgd:S000005959
name: YPL038W
def: "Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog\, MET32\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET31" EXACT []

[Term]
id: sgd:S000005960
name: YPL039W
def: "Putative protein of unknown function; YPL039W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005961
name: YPL040C
def: "Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISM1" EXACT []
synonym: "isoleucine--tRNA ligase ISM1" EXACT []

[Term]
id: sgd:S000005962
name: YPL041C
def: "Protein of unknown function involved in maintenance of telomere length" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005963
name: YPL042C
def: "Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDK8" EXACT []
synonym: "GIG2" EXACT []
synonym: "NUT7" EXACT []
synonym: "RYE5" EXACT []
synonym: "SRB10" EXACT []
synonym: "SSN3" EXACT []
synonym: "SSX7" EXACT []
synonym: "UME5" EXACT []
synonym: "URR1" EXACT []
synonym: "cyclin-dependent serine/threonine protein kinase SSN3" EXACT []

[Term]
id: sgd:S000005964
name: YPL043W
def: "Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs \(RRMs\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP4" EXACT []
synonym: "NOP77" EXACT []

[Term]
id: sgd:S000005965
name: YPL044C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005966
name: YPL045W
def: "Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CVT15" EXACT []
synonym: "SVL6" EXACT []
synonym: "VAM9" EXACT []
synonym: "VPS16" EXACT []
synonym: "VPT16" EXACT []
synonym: "tethering complex subunit VPS16" EXACT []

[Term]
id: sgd:S000005967
name: YPL046C
def: "Elongin C\, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELC1" EXACT []
synonym: "elongin C" EXACT []

[Term]
id: sgd:S000005968
name: YPL047W
def: "Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes\, required for the Ubp8p association with SAGA and for H2B deubiquitylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SGF11" EXACT []

[Term]
id: sgd:S000005969
name: YPL048W
def: "One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A \(Tef1p/Tef2p\) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAM1" EXACT []
synonym: "CPBP" EXACT []
synonym: "TEF3" EXACT []

[Term]
id: sgd:S000005970
name: YPL049C
def: "MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog\, DIG2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIG1" EXACT []
synonym: "RST1" EXACT []

[Term]
id: sgd:S000005971
name: YPL050C
def: "Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p\, Mnn10p\, Mnn11p\, and Hoc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNN9" EXACT []
synonym: "mannosyltransferase complex subunit MNN9" EXACT []

[Term]
id: sgd:S000005972
name: YPL051W
def: "ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p\, a GTPase that regulates membrane traffic\, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor\, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARL3" EXACT []
synonym: "Arf family GTPase ARL3" EXACT []

[Term]
id: sgd:S000005973
name: YPL052W
def: "Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting\, allowing translation of full-length Oaz1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OAZ1" EXACT []
synonym: "YPL052W-A" EXACT []

[Term]
id: sgd:S000005974
name: YPL053C
def: "Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog\, KRE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KTR6" EXACT []
synonym: "MNN6" EXACT []

[Term]
id: sgd:S000005975
name: YPL054W
def: "Zinc-finger protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEE1" EXACT []

[Term]
id: sgd:S000005976
name: YPL055C
def: "Protein of unknown function; null mutant forms abnormally large cells\, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LGE1" EXACT []

[Term]
id: sgd:S000005977
name: YPL056C
def: "Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LCL1" EXACT []

[Term]
id: sgd:S000005978
name: YPL057C
def: "Mannosylinositol phosphorylceramide \(MIPC\) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog\, CSH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BCL21" EXACT []
synonym: "CSG1" EXACT []
synonym: "LPE15" EXACT []
synonym: "SUR1" EXACT []
synonym: "mannosylinositol phosphorylceramide synthase catalytic subunit SUR1" EXACT []

[Term]
id: sgd:S000005979
name: YPL058C
def: "Plasma membrane ATP-binding cassette \(ABC\) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette multidrug transporter PDR12" EXACT []
synonym: "PDR12" EXACT []

[Term]
id: sgd:S000005980
name: YPL059W
def: "Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRX5" EXACT []
synonym: "monothiol glutaredoxin GRX5" EXACT []

[Term]
id: sgd:S000005981
name: YPL060W
def: "Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPE10" EXACT []
synonym: "MFM1" EXACT []

[Term]
id: sgd:S000005982
name: YPL061W
def: "Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALD1" EXACT []
synonym: "ALD6" EXACT []
synonym: "aldehyde dehydrogenase (NADP(+)) ALD6" EXACT []

[Term]
id: sgd:S000005983
name: YPL062W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005984
name: YPL063W
def: "Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane \(TIM23\) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM50" EXACT []

[Term]
id: sgd:S000005985
name: YPL064C
def: "Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWC27" EXACT []
synonym: "putative peptidylprolyl isomerase CWC27" EXACT []

[Term]
id: sgd:S000005986
name: YPL065W
def: "Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p\, Srn2p\, Vps28p\, and Mvb12p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ESCRT-I subunit protein VPS28" EXACT []
synonym: "VPL13" EXACT []
synonym: "VPS28" EXACT []
synonym: "VPT28" EXACT []

[Term]
id: sgd:S000005987
name: YPL066W
def: "Regulator of Rho1p signaling\, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein \(GFP\)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable \(respiratory\) carbon source" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RGL1" EXACT []

[Term]
id: sgd:S000005988
name: YPL067C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005989
name: YPL068C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005990
name: YPL069C
def: "Geranylgeranyl diphosphate synthase \(GGPS\); increases the intracellular pool of geranylgeranyl diphosphate\, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTS1" EXACT []
synonym: "farnesyltranstransferase" EXACT []

[Term]
id: sgd:S000005991
name: YPL070W
def: "Guanine nucleotide exchange factor \(GEF\); involved in vesicle-mediated vacuolar transport\, including Golgi-endosome trafficking and sorting through the multivesicular body \(MVB\); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members \(Vps21p/Ypt52p/Ypt53p\); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MUK1" EXACT []
synonym: "guanine nucleotide exchange factor MUK1" EXACT []

[Term]
id: sgd:S000005992
name: YPL071C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005993
name: YPL072W
def: "Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning\, but may perform a more specialized function at mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UBP16" EXACT []

[Term]
id: sgd:S000005994
name: YPL073C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005995
name: YPL074W
def: "Putative ATPase of the CDC48/PAS1/SEC18 \(AAA\) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YTA6" EXACT []
synonym: "putative AAA family ATPase YTA6" EXACT []

[Term]
id: sgd:S000005996
name: YPL075W
def: "Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCR1" EXACT []
synonym: "LPF10" EXACT []
synonym: "SIT3" EXACT []
synonym: "transcription regulator GCR1" EXACT []

[Term]
id: sgd:S000005997
name: YPL076W
def: "Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol \(GPI\) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCR4" EXACT []
synonym: "GPI2" EXACT []

[Term]
id: sgd:S000005998
name: YPL077C
def: "Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog\, YBR197C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000005999
name: YPL078C
def: "Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex\, which in turn determines the shape of inner membrane cristae; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP4" EXACT []
synonym: "F1F0 ATP synthase subunit 4" EXACT []
synonym: "LPF7" EXACT []

[Term]
id: sgd:S000006000
name: YPL079W
def: "Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21\, no bacterial homolog; RPL21B has a paralog\, RPL21A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L21B" EXACT []
synonym: "L21e" EXACT []
synonym: "RPL21B" EXACT []
synonym: "ribosomal 60S subunit protein L21B" EXACT []

[Term]
id: sgd:S000006001
name: YPL080C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006002
name: YPL081W
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog\, RPS9B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS9A" EXACT []
synonym: "S13" EXACT []
synonym: "S4" EXACT []
synonym: "S9A" EXACT []
synonym: "YS11" EXACT []
synonym: "ribosomal 40S subunit protein S9A" EXACT []
synonym: "rp21" EXACT []

[Term]
id: sgd:S000006003
name: YPL082C
def: "Essential protein involved in regulation of transcription; removes Spt15p \(TBP\) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BTAF1" EXACT []
synonym: "BUR3" EXACT []
synonym: "END10" EXACT []
synonym: "LPF4" EXACT []
synonym: "MOT1" EXACT []

[Term]
id: sgd:S000006004
name: YPL083C
def: "Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p\, Sen15p\, Sen34p\, and Sen54p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEN54" EXACT []

[Term]
id: sgd:S000006005
name: YPL084W
def: "Cytoplasmic class E vacuolar protein sorting \(VPS\) factor; coordinates deubiquitination in the multivesicular body \(MVB\) pathway by recruiting Doa4p to endosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASI6" EXACT []
synonym: "BRO1" EXACT []
synonym: "LPF2" EXACT []
synonym: "NPI3" EXACT []
synonym: "VPS31" EXACT []

[Term]
id: sgd:S000006006
name: YPL085W
def: "COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site \(ERES\) formation\, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p\, Sec24p and Sec31p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPF1" EXACT []
synonym: "SEC16" EXACT []

[Term]
id: sgd:S000006007
name: YPL086C
def: "Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP3" EXACT []
synonym: "Elongator subunit ELP3" EXACT []
synonym: "HPA1" EXACT []
synonym: "KAT9" EXACT []
synonym: "KTI8" EXACT []
synonym: "TOT3" EXACT []

[Term]
id: sgd:S000006008
name: YPL087W
def: "Alkaline dihydroceramidase\, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog\, YPC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDC1" EXACT []
synonym: "alkaline dihydroceramidase" EXACT []

[Term]
id: sgd:S000006009
name: YPL088W
def: "Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "aldo-keto reductase superfamily protein" EXACT []

[Term]
id: sgd:S000006010
name: YPL089C
def: "MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog\, SMP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RLM1" EXACT []

[Term]
id: sgd:S000006011
name: YPL090C
def: "Protein component of the small \(40S\) ribosomal subunit; homologous to mammalian ribosomal protein S6\, no bacterial homolog; RPS6A has a paralog\, RPS6B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS6A" EXACT []
synonym: "S10A" EXACT []
synonym: "S6A" EXACT []
synonym: "S6e" EXACT []
synonym: "YS4" EXACT []
synonym: "ribosomal 40S subunit protein S6A" EXACT []
synonym: "rp9" EXACT []

[Term]
id: sgd:S000006012
name: YPL091W
def: "Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLR1" EXACT []
synonym: "LPG17" EXACT []
synonym: "glutathione-disulfide reductase GLR1" EXACT []

[Term]
id: sgd:S000006013
name: YPL092W
def: "Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPG16" EXACT []
synonym: "SSU1" EXACT []

[Term]
id: sgd:S000006014
name: YPL093W
def: "Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOG1" EXACT []

[Term]
id: sgd:S000006015
name: YPL094C
def: "Essential subunit of Sec63 complex; with Sec61 complex\, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p\, Sec66p\, and Sec72p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPG14" EXACT []
synonym: "SEC62" EXACT []
synonym: "Sec63 complex subunit SEC62" EXACT []

[Term]
id: sgd:S000006016
name: YPL095C
def: "Acyl-coenzymeA\:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog\, EHT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EEB1" EXACT []

[Term]
id: sgd:S000006017
name: YPL096W
def: "Conserved peptide N-glycanase; required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PNG1" EXACT []

[Term]
id: sgd:S000006018
name: YPL097W
def: "Mitochondrial tyrosyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSY1" EXACT []
synonym: "tyrosine--tRNA ligase MSY1" EXACT []

[Term]
id: sgd:S000006019
name: YPL098C
def: "Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome \(petite-negative phenotype\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MGR2" EXACT []

[Term]
id: sgd:S000006020
name: YPL099C
def: "F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex \(Ina22p-Ina17p\) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM43" EXACT []
synonym: "FMP14" EXACT []
synonym: "INA17" EXACT []

[Term]
id: sgd:S000006021
name: YPL100W
def: "Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting \(Cvt\) pathway; binds both phosphatidylinositol \(3\,5\)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG21" EXACT []
synonym: "HSV1" EXACT []
synonym: "MAI1" EXACT []

[Term]
id: sgd:S000006022
name: YPL101W
def: "Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ELP4" EXACT []
synonym: "Elongator subunit ELP4" EXACT []
synonym: "HAP1" EXACT []
synonym: "KTI9" EXACT []
synonym: "TOT7" EXACT []

[Term]
id: sgd:S000006023
name: YPL102C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae\, but this is likely due to effects on the overlapping gene ELP4" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006024
name: YPL103C
def: "Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP30" EXACT []

[Term]
id: sgd:S000006025
name: YPL104W
def: "Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-\, asparaginyl-\, and lysyl-tRNA synthetases contain regions with high sequence similarity\, suggesting a common ancestral gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPG5" EXACT []
synonym: "MSD1" EXACT []
synonym: "aspartate--tRNA ligase MSD1" EXACT []

[Term]
id: sgd:S000006026
name: YPL105C
def: "Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain\, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog\, SMY2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MYR1" EXACT []
synonym: "SYH1" EXACT []

[Term]
id: sgd:S000006027
name: YPL106C
def: "ATPase component of heat shock protein Hsp90 chaperone complex; plays a role in determining prion variants; binds unfolded proteins; member of the heat shock protein 70 \(HSP70\) family; localized to the cytoplasm; deletion results in spindle elongation in S phase; SSE1 has a paralog\, SSE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPG3" EXACT []
synonym: "MSI3" EXACT []
synonym: "SSE1" EXACT []
synonym: "adenyl-nucleotide exchange factor SSE1" EXACT []

[Term]
id: sgd:S000006028
name: YPL107W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria; YPL107W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006029
name: YPL108W
def: "Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006030
name: YPL109C
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006031
name: YPL110C
def: "Glycerophosphocholine \(GroPCho\) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate\, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GDE1" EXACT []

[Term]
id: sgd:S000006032
name: YPL111W
def: "Arginase\, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAR1" EXACT []
synonym: "LPH15" EXACT []
synonym: "arginase" EXACT []
synonym: "cargA" EXACT []

[Term]
id: sgd:S000006033
name: YPL112C
def: "Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance\, recruits GTPase Rho1p to peroxisomes\, induced by oleate\, interacts with Pex27p; PEX25 has a paralog\, PEX27\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEX25" EXACT []

[Term]
id: sgd:S000006034
name: YPL113C
def: "Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "glyoxylate reductase" EXACT []

[Term]
id: sgd:S000006035
name: YPL114W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006036
name: YPL115C
def: "Rho GTPase activating protein \(RhoGAP\); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p\, which controls establishment and maintenance of cell polarity\, including bud-site assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEM3" EXACT []

[Term]
id: sgd:S000006037
name: YPL116W
def: "Trichostatin A-insensitive homodimeric histone deacetylase \(HDAC\); specificity in vitro for histones H3\, H4\, H2A\, and H2B; similar to Hda1p\, Rpd3p\, Hos1p\, and Hos2p; deletion results in increased histone acetylation at rDNA repeats" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HOS3" EXACT []

[Term]
id: sgd:S000006038
name: YPL117C
def: "Isopentenyl diphosphate\:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate\:dimethylallyl diphosphate isomerase is also known as IPP isomerase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOT2" EXACT []
synonym: "IDI1" EXACT []
synonym: "LPH10" EXACT []
synonym: "isopentenyl-diphosphate delta-isomerase IDI1" EXACT []

[Term]
id: sgd:S000006039
name: YPL118W
def: "Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP51" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRP51" EXACT []

[Term]
id: sgd:S000006040
name: YPL119C
def: "Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog\, DED1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBP1" EXACT []
synonym: "LPH8" EXACT []
synonym: "putative DEAD-box ATP-dependent RNA helicase DBP1" EXACT []

[Term]
id: sgd:S000006041
name: YPL120W
def: "Subunit of phosphatidylinositol \(PtdIns\) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has a novel globular fold that is essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of the higher eukaryotic gene Beclin 1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG6" EXACT []
synonym: "ATG6" EXACT []
synonym: "VPS30" EXACT []
synonym: "VPT30" EXACT []

[Term]
id: sgd:S000006042
name: YPL121C
def: "Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPH6" EXACT []
synonym: "MEI5" EXACT []

[Term]
id: sgd:S000006043
name: YPL122C
def: "Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation\, required for nucleotide excision repair\, similar to 52 kDa subunit of human TFIIH" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFB2" EXACT []
synonym: "TFIIH/NER complex subunit TFB2" EXACT []

[Term]
id: sgd:S000006044
name: YPL123C
def: "Vacuolar RNase of the T\(2\) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RNY1" EXACT []

[Term]
id: sgd:S000006045
name: YPL124W
def: "Inner plaque spindle pole body \(SPB\) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPH3" EXACT []
synonym: "NIP29" EXACT []
synonym: "SPC29" EXACT []

[Term]
id: sgd:S000006046
name: YPL125W
def: "Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAP120" EXACT []
synonym: "LPH2" EXACT []

[Term]
id: sgd:S000006047
name: YPL126W
def: "U3 snoRNP protein; component of the small \(ribosomal\) subunit \(SSU\) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAN1" EXACT []
synonym: "UTP17" EXACT []

[Term]
id: sgd:S000006048
name: YPL127C
def: "Histone H1\, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis\, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions\, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HHO1" EXACT []
synonym: "histone H1" EXACT []

[Term]
id: sgd:S000006049
name: YPL128C
def: "Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions \(STARs\)\, blocking silent chromatin propagation; binds majority of snoRNA gene promoters\, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPI16" EXACT []
synonym: "TBF1" EXACT []

[Term]
id: sgd:S000006050
name: YPL129W
def: "Subunit of TFIID\, TFIIF\, INO80\, SWI/SNF\, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANC1" EXACT []
synonym: "SWP29" EXACT []
synonym: "TAF14" EXACT []
synonym: "TAF30" EXACT []
synonym: "TATA-binding protein-associated factor TAF14" EXACT []
synonym: "TFG3" EXACT []
synonym: "TafII30" EXACT []

[Term]
id: sgd:S000006051
name: YPL130W
def: "Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog\, YOR214C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO19" EXACT []

[Term]
id: sgd:S000006052
name: YPL131W
def: "Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L18" EXACT []
synonym: "L1a" EXACT []
synonym: "L5" EXACT []
synonym: "LPI14" EXACT []
synonym: "RPL1" EXACT []
synonym: "RPL5" EXACT []
synonym: "YL3" EXACT []
synonym: "ribosomal 60S subunit protein L5" EXACT []

[Term]
id: sgd:S000006053
name: YPL132W
def: "Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX11" EXACT []
synonym: "LPI13" EXACT []
synonym: "PSO7" EXACT []

[Term]
id: sgd:S000006054
name: YPL133C
def: "Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDS2" EXACT []

[Term]
id: sgd:S000006055
name: YPL134C
def: "Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter\, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses\, in multicopy\, an fmc1 null mutation; ODC1 has a paralog\, ODC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ODC1" EXACT []

[Term]
id: sgd:S000006056
name: YPL135W
def: "Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters\, interacts physically and functionally with yeast frataxin \(Yfh1p\); isu1 isu2 double mutant is inviable; ISU1 has a paralog\, ISU2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISU1" EXACT []
synonym: "NUA1" EXACT []
synonym: "iron-binding protein ISU1" EXACT []

[Term]
id: sgd:S000006057
name: YPL136W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006058
name: YPL137C
def: "Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes\, based on co-purification experiments; GIP3 has a paralog\, HER1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GIP3" EXACT []
synonym: "protein phosphatase regulator GIP3" EXACT []

[Term]
id: sgd:S000006059
name: YPL138C
def: "Subunit of COMPASS \(Set1C\); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP\, an unmethylated CpG binding protein; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CPS40" EXACT []
synonym: "SAF41" EXACT []
synonym: "SPP1" EXACT []

[Term]
id: sgd:S000006060
name: YPL139C
def: "Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth\, binding of histone deacetylase Rpd3p required for activity\, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog\, WTM2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UME1" EXACT []
synonym: "WTM3" EXACT []

[Term]
id: sgd:S000006061
name: YPL140C
def: "MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target\, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog\, MKK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LPI6" EXACT []
synonym: "MKK2" EXACT []
synonym: "SSP33" EXACT []
synonym: "putative mitogen-activated protein kinase kinase MKK2" EXACT []

[Term]
id: sgd:S000006062
name: YPL141C
def: "Protein kinase of unknown cellular role; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog\, KIN4\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FRK1" EXACT []
synonym: "protein kinase FRK1" EXACT []

[Term]
id: sgd:S000006063
name: YPL142C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W\, a component of the large \(60S\) ribosomal subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006064
name: YPL143W
def: "Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A\, no bacterial homolog; RPL33A has a paralog\, RPL33B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L33A" EXACT []
synonym: "L33e" EXACT []
synonym: "RPL33A" EXACT []
synonym: "RPL37A" EXACT []
synonym: "YL37" EXACT []
synonym: "l37A" EXACT []
synonym: "ribosomal 60S subunit protein L33A" EXACT []
synonym: "rp47" EXACT []

[Term]
id: sgd:S000006065
name: YPL144W
def: "Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DMP1" EXACT []
synonym: "PBA4" EXACT []
synonym: "POC4" EXACT []

[Term]
id: sgd:S000006066
name: YPL145C
def: "One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions\, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog\, HES1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSR3" EXACT []
synonym: "KES1" EXACT []
synonym: "LPI3" EXACT []
synonym: "OSH4" EXACT []
synonym: "oxysterol-binding protein KES1" EXACT []

[Term]
id: sgd:S000006067
name: YPL146C
def: "Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP53" EXACT []
synonym: "RRP16" EXACT []

[Term]
id: sgd:S000006068
name: YPL147W
def: "Subunit of a heterodimeric peroxisomal ABC transport complex; required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy \(X-ALD\)\, a peroxisomal disorder; complex also includes Pxa2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette long-chain fatty acid transporter PXA1" EXACT []
synonym: "LPI1" EXACT []
synonym: "PAL1" EXACT []
synonym: "PAT2" EXACT []
synonym: "PXA1" EXACT []
synonym: "SSH2" EXACT []

[Term]
id: sgd:S000006069
name: YPL148C
def: "Phosphopantetheine\:protein transferase \(PPTase\); activates mitochondrial acyl carrier protein \(Acp1p\) by phosphopantetheinylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPT2" EXACT []

[Term]
id: sgd:S000006070
name: YPL149W
def: "Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG5" EXACT []
synonym: "ATG5" EXACT []

[Term]
id: sgd:S000006071
name: YPL150W
def: "Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "non-specific serine/threonine protein kinase" EXACT []

[Term]
id: sgd:S000006072
name: YPL151C
def: "Member of the NineTeen Complex \(NTC\); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTC50" EXACT []
synonym: "PRP46" EXACT []

[Term]
id: sgd:S000006073
name: YPL152W
def: "Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A \(PP2A\); regulates G1 phase progression\, the osmoresponse\, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRD2" EXACT []
synonym: "YPA2" EXACT []
synonym: "peptidylprolyl isomerase RRD2" EXACT []

[Term]
id: sgd:S000006074
name: YPL153C
def: "DNA damage response protein kinase; required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication; activates the downstream kinase Dun1p; differentially senses mtDNA depletion and mitochondrial ROS; required for regulation of copper genes in response to DNA-damaging agents; relocalizes to cytosol in response to hyoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSD1" EXACT []
synonym: "MEC2" EXACT []
synonym: "RAD53" EXACT []
synonym: "SPK1" EXACT []
synonym: "serine/threonine/tyrosine protein kinase RAD53" EXACT []

[Term]
id: sgd:S000006075
name: YPL154C
def: "Vacuolar aspartyl protease \(proteinase A\); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen\, self-activates" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PEP4" EXACT []
synonym: "PHO9" EXACT []
synonym: "PRA1" EXACT []
synonym: "proteinase A" EXACT []
synonym: "yscA" EXACT []

[Term]
id: sgd:S000006076
name: YPL155C
def: "Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KIP2" EXACT []

[Term]
id: sgd:S000006077
name: YPL156C
def: "Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM4" EXACT []
synonym: "pheromone-regulated protein PRM4" EXACT []

[Term]
id: sgd:S000006078
name: YPL157W
def: "Trimethyl guanosine synthase\, conserved nucleolar methyl transferase; converts the m\(7\)G cap structure of snRNAs\, snoRNAs\, and telomerase TLC1 RNA to m\(2\,2\,7\)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p\, which may confer substrate specificity on Tgs1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TGS1" EXACT []

[Term]
id: sgd:S000006079
name: YPL158C
def: "Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM44" EXACT []
synonym: "GPS1" EXACT []

[Term]
id: sgd:S000006080
name: YPL159C
def: "Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PET20" EXACT []

[Term]
id: sgd:S000006081
name: YPL160W
def: "Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC60" EXACT []
synonym: "LeuRS" EXACT []
synonym: "leucine--tRNA ligase CDC60" EXACT []

[Term]
id: sgd:S000006082
name: YPL161C
def: "Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BEM4" EXACT []
synonym: "ROM7" EXACT []

[Term]
id: sgd:S000006083
name: YPL162C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006084
name: YPL163C
def: "Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog\, SRL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SVS1" EXACT []

[Term]
id: sgd:S000006085
name: YPL164C
def: "Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLH3" EXACT []
synonym: "mismatch repair protein MLH3" EXACT []

[Term]
id: sgd:S000006086
name: YPL165C
def: "SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis\, may be involved in compound availability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SET6" EXACT []

[Term]
id: sgd:S000006087
name: YPL166W
def: "Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure \(PAS\); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG29" EXACT []

[Term]
id: sgd:S000006088
name: YPL167C
def: "Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p\, Pol31p and Pol32p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PSO1" EXACT []
synonym: "REV3" EXACT []

[Term]
id: sgd:S000006089
name: YPL168W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006090
name: YPL169C
def: "Poly\(A\)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEX67" EXACT []

[Term]
id: sgd:S000006091
name: YPL170W
def: "Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein\, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres\, mitochondria\, and sterol synthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAP1" EXACT []

[Term]
id: sgd:S000006092
name: YPL171C
def: "Conserved NADPH oxidoreductase containing flavin mononucleotide \(FMN\); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OYE3" EXACT []
synonym: "ZRG6" EXACT []

[Term]
id: sgd:S000006093
name: YPL172C
def: "Heme A\:farnesyltransferase; catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX10" EXACT []

[Term]
id: sgd:S000006094
name: YPL173W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL40" EXACT []
synonym: "YmL40" EXACT []
synonym: "mitochondrial 54S ribosomal protein YmL40" EXACT []

[Term]
id: sgd:S000006095
name: YPL174C
def: "Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150\(glued\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIP100" EXACT []
synonym: "PAC13" EXACT []

[Term]
id: sgd:S000006096
name: YPL175W
def: "UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol \(GPI\) biosynthesis\, mutations cause defects in transcription and in biogenesis of cell wall proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH6" EXACT []
synonym: "GPI3" EXACT []
synonym: "SPT14" EXACT []

[Term]
id: sgd:S000006097
name: YPL176C
def: "Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog\, TRE2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TRE1" EXACT []

[Term]
id: sgd:S000006098
name: YPL177C
def: "Homeodomain-containing transcriptional repressor; regulates expression of PTR2\, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis\, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog\, TOS8\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUP9" EXACT []

[Term]
id: sgd:S000006099
name: YPL178W
def: "Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p\, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBC2" EXACT []
synonym: "CBP20" EXACT []
synonym: "MUD13" EXACT []
synonym: "SAE1" EXACT []

[Term]
id: sgd:S000006100
name: YPL179W
def: "Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PPQ1" EXACT []
synonym: "SAL6" EXACT []

[Term]
id: sgd:S000006101
name: YPL180W
def: "Subunit of TORC1 \(Tor1p or Tor2p-Kog1p-Lst8p-Tco89p\); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TCO89" EXACT []

[Term]
id: sgd:S000006102
name: YPL181W
def: "Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTI6" EXACT []
synonym: "RXT1" EXACT []

[Term]
id: sgd:S000006103
name: YPL182C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006104
name: YPL183C
def: "WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERE2" EXACT []
synonym: "RTT10" EXACT []
synonym: "TRM734" EXACT []

[Term]
id: sgd:S000006105
name: YPL184C
def: "RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs\, including those that contain upstream open reading frames \(uORFs\) and internal ribosome entry sites \(IRES\); interacts genetically with chromatin remodelers and splicing factors\, linking chromatin state\, splicing and as a result mRNA maturation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRN1" EXACT []
synonym: "PTR69" EXACT []

[Term]
id: sgd:S000006106
name: YPL185W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006107
name: YPL186C
def: "Protein that interacts with Ulp1p; a Ubl \(ubiquitin-like protein\)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "UIP4" EXACT []

[Term]
id: sgd:S000006108
name: YPL187W
def: "Mating pheromone alpha-factor\, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF\(ALPHA\)2\, although MF\(ALPHA\)1 produces most alpha-factor; MF\(ALPHA\)1 has a paralog\, MF\(ALPHA\)2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MF(ALPHA)1" EXACT []

[Term]
id: sgd:S000006109
name: YPL188W
def: "Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD\(+\) with lower specificity; required for the response to oxidative stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "POS5" EXACT []

[Term]
id: sgd:S000006110
name: YPL189W
def: "Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; GUP2 has a paralog\, GUP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GUP2" EXACT []

[Term]
id: sgd:S000006111
name: YPL190C
def: "RNA-binding protein\, subunit of Nrd1 complex \(Nrd1p-Nab3p-Sen1p\); complex interacts with exosome to mediate 3'-end formation of some mRNAs\, snRNAs\, snoRNAs\, and CUTs; required for termination of non-poly\(A\) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions\, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HMD1" EXACT []
synonym: "NAB3" EXACT []

[Term]
id: sgd:S000006112
name: YPL191C
def: "Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; YPL191C has a paralog\, YGL082W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006113
name: YPL192C
def: "Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRM3" EXACT []
synonym: "pheromone-regulated protein PRM3" EXACT []

[Term]
id: sgd:S000006114
name: YPL193W
def: "Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RSA1" EXACT []

[Term]
id: sgd:S000006115
name: YPL194W
def: "DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response\, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DDC1" EXACT []

[Term]
id: sgd:S000006116
name: YPL195W
def: "Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL5" EXACT []
synonym: "YKS4" EXACT []

[Term]
id: sgd:S000006117
name: YPL196W
def: "Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OXR1" EXACT []

[Term]
id: sgd:S000006118
name: YPL197C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006119
name: YPL198W
def: "Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain \(NDB2\); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog\, RPL7A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L30" EXACT []
synonym: "L6B" EXACT []
synonym: "L7B" EXACT []
synonym: "RPL7B" EXACT []
synonym: "YL8" EXACT []
synonym: "ribosomal 60S subunit protein L7B" EXACT []
synonym: "rp11" EXACT []

[Term]
id: sgd:S000006120
name: YPL199C
def: "Putative protein of unknown function; predicted to be palmitoylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006121
name: YPL200W
def: "Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering \(bouquet formation\) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog\, MPS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CSM4" EXACT []

[Term]
id: sgd:S000006122
name: YPL201C
def: "Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIG1" EXACT []

[Term]
id: sgd:S000006123
name: YPL202C
def: "Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog\, AFT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AFT2" EXACT []

[Term]
id: sgd:S000006124
name: YPL203W
def: "cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PKA2" EXACT []
synonym: "PKA3" EXACT []
synonym: "TPK2" EXACT []
synonym: "YKR1" EXACT []
synonym: "cAMP-dependent protein kinase catalytic subunit TPK2" EXACT []

[Term]
id: sgd:S000006125
name: YPL204W
def: "Protein kinase; involved in regulating diverse events including vesicular trafficking\, DNA repair\, and chromosome segregation; binds the CTD of RNA pol II; phosphorylates the COPII coat; phosphorylates Tif6p which plays a critical role in 60S ribosomal subunit biogenesis; interacts with Sit4p phosphatase; homolog of mammalian casein kinase 1delta \(CK1delta\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HRR25" EXACT []
synonym: "KTI14" EXACT []
synonym: "serine/threonine protein kinase HRR25" EXACT []

[Term]
id: sgd:S000006126
name: YPL205C
def: "Hypothetical protein; deletion of locus affects telomere length" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006127
name: YPL206C
def: "Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol \(PG\) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PGC1" EXACT []

[Term]
id: sgd:S000006128
name: YPL207W
def: "Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TYW1" EXACT []

[Term]
id: sgd:S000006129
name: YPL208W
def: "SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 \(Rpl23Ap and Rpl23Bp\) and monomethyllysine residues on L18 \(Rps18Ap and Rps18Bp\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RKM1" EXACT []

[Term]
id: sgd:S000006130
name: YPL209C
def: "Aurora kinase of conserved chromosomal passenger complex; mediates release on mono-oriented kinetochores from microtubules in meiosis I\, also release of kinetochores from cluster at SPBs at meiosis exit; helps maintain condensed chromosomes during anaphase\, early telophase; required for SPB cohesion and prevention of multipolar spindle formation; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IPL1" EXACT []
synonym: "PAC15" EXACT []
synonym: "aurora kinase" EXACT []

[Term]
id: sgd:S000006131
name: YPL210C
def: "Core component of the signal recognition particle \(SRP\); the SRP is a ribonucleoprotein \(RNP\) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum \(ER\) membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP72" EXACT []

[Term]
id: sgd:S000006132
name: YPL211W
def: "Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NIP7" EXACT []

[Term]
id: sgd:S000006133
name: YPL212C
def: "tRNA\:pseudouridine synthase; introduces pseudouridines at positions 26-28\, 34-36\, 65\, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs\, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog\, PUS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUS1" EXACT []
synonym: "pseudouridine synthase PUS1" EXACT []

[Term]
id: sgd:S000006134
name: YPL213W
def: "Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LEA1" EXACT []

[Term]
id: sgd:S000006135
name: YPL214C
def: "Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI6" EXACT []
synonym: "bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase" EXACT []

[Term]
id: sgd:S000006136
name: YPL215W
def: "Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b \(Cobp\) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked\, downregulating COB mRNA translation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CBP3" EXACT []

[Term]
id: sgd:S000006137
name: YPL216W
def: "Putative protein of unknown function; not an essential gene; YPL216W has a paralog\, ITC1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006138
name: YPL217C
def: "GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0\, A1\, and A2; interacts with Rcl1p\, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BMS1" EXACT []
synonym: "GTPase BMS1" EXACT []

[Term]
id: sgd:S000006139
name: YPL218W
def: "GTPase\, GTP-binding protein of the ARF family; component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity helping in vesicle formation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family GTPase SAR1" EXACT []
synonym: "SAR1" EXACT []

[Term]
id: sgd:S000006140
name: YPL219W
def: "Cyclin; interacts with Pho85p cyclin-dependent kinase \(Cdk\) to phosphorylate and regulate glycogen synthase\, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog\, PCL10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCL8" EXACT []

[Term]
id: sgd:S000006141
name: YPL220W
def: "Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog\, RPL1B\, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L1" EXACT []
synonym: "L1A" EXACT []
synonym: "PUB2" EXACT []
synonym: "RPL1A" EXACT []
synonym: "SSM1" EXACT []
synonym: "ribosomal 60S subunit protein L1A" EXACT []

[Term]
id: sgd:S000006142
name: YPL221W
def: "Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog\, FLC3\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BOP1" EXACT []
synonym: "FLC1" EXACT []
synonym: "HUF1" EXACT []

[Term]
id: sgd:S000006143
name: YPL222W
def: "Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FMP40" EXACT []

[Term]
id: sgd:S000006144
name: YPL223C
def: "Hydrophilin essential in desiccation-rehydration process; stress induced \(osmotic\, ionic\, oxidative\, heat shock and heavy metals\); regulated by the HOG pathway; GRE1 has a paralog\, SIP18\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRE1" EXACT []

[Term]
id: sgd:S000006145
name: YPL224C
def: "Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog\, MMT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MFT2" EXACT []
synonym: "MMT2" EXACT []

[Term]
id: sgd:S000006146
name: YPL225W
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006147
name: YPL226W
def: "ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports \[NU+\] prion formation and susceptibility to \[PSI+\] prion induction" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEW1" EXACT []

[Term]
id: sgd:S000006148
name: YPL227C
def: "UDP-glucose\:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ALG5" EXACT []
synonym: "dolichyl-phosphate beta-glucosyltransferase" EXACT []

[Term]
id: sgd:S000006149
name: YPL228W
def: "RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of the mRNA capping enzyme\, which is a heterotetramer composed of a Cet1p homodimer and two molecules of the guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNA pol II pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog\, CTL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CES5" EXACT []
synonym: "CET1" EXACT []

[Term]
id: sgd:S000006150
name: YPL229W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog\, YMR181C\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006151
name: YPL230W
def: "Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources\, response to salt stress and cell wall biosynthesis; USV1 has a paralog\, RGM1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NSF1" EXACT []
synonym: "USV1" EXACT []

[Term]
id: sgd:S000006152
name: YPL231W
def: "Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase\, beta-ketoacyl synthase and self-pantetheinylation activities" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FAS2" EXACT []
synonym: "trifunctional fatty acid synthase subunit FAS2" EXACT []

[Term]
id: sgd:S000006153
name: YPL232W
def: "Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog\, SSO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SSO1" EXACT []

[Term]
id: sgd:S000006154
name: YPL233W
def: "Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p \(MIND\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIND complex subunit NSL1" EXACT []
synonym: "NSL1" EXACT []

[Term]
id: sgd:S000006155
name: YPL234C
def: "Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein \(proteolipid\) containing four transmembrane segments; N and C termini are in the vacuolar lumen" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS9" EXACT []
synonym: "H(+)-transporting V0 sector ATPase subunit c'" EXACT []
synonym: "TFP3" EXACT []
synonym: "VMA11" EXACT []

[Term]
id: sgd:S000006156
name: YPL235W
def: "ATP-dependent DNA helicase\, also known as reptin; member of the AAA+ and RuvB protein families\, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex\, the Swr1 complex\, and the R2TP complex \(Rvb1-Rvb2-Tah1-Pih1\); involved in multiple processes such as chromatin remodeling\, box C/D snoRNP assembly\, and RNA polymerase II assembly" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RVB2" EXACT []
synonym: "RuvB family ATP-dependent DNA helicase reptin" EXACT []
synonym: "TIH2" EXACT []
synonym: "TIP48" EXACT []
synonym: "TIP49B" EXACT []

[Term]
id: sgd:S000006157
name: YPL236C
def: "Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 \(STK16\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ENV7" EXACT []
synonym: "putative serine/threonine protein kinase ENV7" EXACT []

[Term]
id: sgd:S000006158
name: YPL237W
def: "Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUI3" EXACT []
synonym: "translation initiation factor eIF2 subunit beta" EXACT []

[Term]
id: sgd:S000006159
name: YPL238C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006160
name: YPL239W
def: "Ankyrin-repeat containing\, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm\, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export\, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAR1" EXACT []

[Term]
id: sgd:S000006161
name: YPL240C
def: "Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling\, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding\, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog\, HSC82\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP82" EXACT []
synonym: "HSP90" EXACT []
synonym: "Hsp90 family chaperone HSP82" EXACT []

[Term]
id: sgd:S000006162
name: YPL241C
def: "GTPase-activating protein \(GAP\) for Cin4p; tubulin folding factor C involved in beta-tubulin \(Tub2p\) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP\, retinitis pigmentosa 2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIN2" EXACT []

[Term]
id: sgd:S000006163
name: YPL242C
def: "Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p\, localizes to the contractile ring during anaphase\, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CYK1" EXACT []
synonym: "IQG1" EXACT []

[Term]
id: sgd:S000006164
name: YPL243W
def: "Core component of the signal recognition particle \(SRP\) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum \(ER\) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRP68" EXACT []

[Term]
id: sgd:S000006165
name: YPL244C
def: "Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1\, exhibits a genetic interaction with S. cerevisiae ERO1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUT1" EXACT []

[Term]
id: sgd:S000006166
name: YPL245W
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to both the nucleus and the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006167
name: YPL246C
def: "Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBD2" EXACT []

[Term]
id: sgd:S000006168
name: YPL247C
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006169
name: YPL248C
def: "DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GAL4" EXACT []
synonym: "GAL81" EXACT []
synonym: "galactose-responsive transcription factor GAL4" EXACT []

[Term]
id: sgd:S000006170
name: YPL249C
def: "GTPase-activating protein \(GAP\) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p\, also acts on Sec4p; interacts with Gyl1p\, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog\, GYL1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GYP5" EXACT []

[Term]
id: sgd:S000006171
name: YPL250C
def: "Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ICY2 has a paralog\, ICY1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICY2" EXACT []

[Term]
id: sgd:S000006172
name: YPL251W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified\, essential gene YAH1/YPL252C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006173
name: YPL252C
def: "Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YAH1" EXACT []

[Term]
id: sgd:S000006174
name: YPL253C
def: "Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog\, CIK1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VIK1" EXACT []

[Term]
id: sgd:S000006175
name: YPL254W
def: "Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADA1" EXACT []
synonym: "GAN1" EXACT []
synonym: "HFI1" EXACT []
synonym: "SRM12" EXACT []
synonym: "SUP110" EXACT []

[Term]
id: sgd:S000006176
name: YPL255W
def: "Protein required for the spindle pole body \(SPB\) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BBP1" EXACT []

[Term]
id: sgd:S000006177
name: YPL256C
def: "G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes\, MBF \(Swi6p-Mbp1p\) and SBF \(Swi6p-Swi4p\); CLN2 has a paralog\, CLN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLN2" EXACT []
synonym: "cyclin CLN2" EXACT []

[Term]
id: sgd:S000006178
name: YPL257W
def: "Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006179
name: YPL258C
def: "Hydroxymethylpyrimidine \(HMP\) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI21" EXACT []
synonym: "bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase" EXACT []

[Term]
id: sgd:S000006180
name: YPL259C
def: "Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APM1" EXACT []
synonym: "YAP54" EXACT []

[Term]
id: sgd:S000006181
name: YPL260W
def: "Putative substrate of cAMP-dependent protein kinase \(PKA\); green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006182
name: YPL261C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YPL260W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006183
name: YPL262W
def: "Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence\, protein conformation\, and status of glyoxylate shunt; phosphorylated in mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FUM1" EXACT []
synonym: "fumarase FUM1" EXACT []

[Term]
id: sgd:S000006184
name: YPL263C
def: "Cytoplasmic protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KEL3" EXACT []

[Term]
id: sgd:S000006185
name: YPL264C
def: "Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006186
name: YPL265W
def: "Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln\, Asn\, Ser\, Ala\, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIP5" EXACT []

[Term]
id: sgd:S000006187
name: YPL266W
def: "Essential 18S rRNA dimethylase \(dimethyladenosine transferase\); responsible for conserved m6\(2\)Am6\(2\)A dimethylation in 3'-terminal loop of 18S rRNA\, part of 90S and 40S pre-particles in nucleolus\, involved in pre-ribosomal RNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDH1" EXACT []
synonym: "DIM1" EXACT []

[Term]
id: sgd:S000006188
name: YPL267W
def: "Pseudosubstrate inhibitor of the APC/C; suppresses APC/C \[Cdh1\]-mediated proteolysis of mitotic cyclins; associates with Cdh1p\, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACM1" EXACT []

[Term]
id: sgd:S000006189
name: YPL268W
def: "Phospholipase C; hydrolyzes phosphatidylinositol 4\,5-biphosphate \(PIP2\) to generate the signaling molecules inositol 1\,4\,5-triphosphate \(IP3\) and 1\,2-diacylglycerol \(DAG\); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PLC1" EXACT []
synonym: "phosphatidylinositol phospholipase C" EXACT []

[Term]
id: sgd:S000006190
name: YPL269W
def: "Karyogamy protein; required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules; localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAR9" EXACT []

[Term]
id: sgd:S000006191
name: YPL270W
def: "Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP-binding cassette permease MDL2" EXACT []
synonym: "MDL2" EXACT []

[Term]
id: sgd:S000006192
name: YPL271W
def: "Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP15" EXACT []
synonym: "ATPEPSILON" EXACT []
synonym: "F1F0 ATP synthase subunit epsilon" EXACT []

[Term]
id: sgd:S000006193
name: YPL272C
def: "Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PBI1" EXACT []

[Term]
id: sgd:S000006194
name: YPL273W
def: "S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine \(AdoMet\) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog\, YMR321C\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAM4" EXACT []

[Term]
id: sgd:S000006195
name: YPL274W
def: "High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SAM3" EXACT []
synonym: "bifunctional polyamine/amino acid permease SAM3" EXACT []

[Term]
id: sgd:S000006198
name: YPL277C
def: "Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006199
name: YPL278C
def: "Putative protein of unknown function; gene expression regulated by copper levels" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006200
name: YPL279C
def: "Protein involved in fluoride export; nearly identical to FEX1\, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FEX2" EXACT []

[Term]
id: sgd:S000006201
name: YPL280W
def: "Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p\, Hsp33p\, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily\, which includes human DJ-1 involved in Parkinson's disease and cancer" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSP32" EXACT []

[Term]
id: sgd:S000006202
name: YPL281C
def: "Enolase\, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERR2" EXACT []
synonym: "phosphopyruvate hydratase ERR2" EXACT []

[Term]
id: sgd:S000006203
name: YPL282C
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau21p; encodes 2 proteins that are translated from 2 different start codons" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU22" EXACT []
synonym: "seripauperin PAU22" EXACT []

[Term]
id: sgd:S000006204
name: YPL283C
def: "Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 7" EXACT []
synonym: "YRF1" EXACT []
synonym: "YRF1-7" EXACT []

[Term]
id: sgd:S000006205
name: YPR001W
def: "Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CIT3" EXACT []
synonym: "citrate (Si)-synthase CIT3" EXACT []

[Term]
id: sgd:S000006206
name: YPR002W
def: "Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD\, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PDH1" EXACT []

[Term]
id: sgd:S000006207
name: YPR003C
def: "Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein \(GFP\)-fusion protein localizes to the ER; YPR003C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006208
name: YPR004C
def: "Putative ortholog of mammalian ETF-alpha; interacts with frataxin\, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIM45" EXACT []

[Term]
id: sgd:S000006209
name: YPR005C
def: "Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ \(via Ena1p\) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl\, KCl\, and sorbitol through Gcn4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAL1" EXACT []

[Term]
id: sgd:S000006210
name: YPR006C
def: "2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ICL2" EXACT []
synonym: "methylisocitrate lyase ICL2" EXACT []

[Term]
id: sgd:S000006211
name: YPR007C
def: "Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; independent of its role in sister chromatid cohesion\, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REC8" EXACT []
synonym: "SPO69" EXACT []

[Term]
id: sgd:S000006212
name: YPR008W
def: "Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2\, YRO2\, and other genes encoding membrane stress proteins; HAA1 has a paralog\, CUP2\, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HAA1" EXACT []

[Term]
id: sgd:S000006213
name: YPR009W
def: "Putative transcription factor of the Zn2Cys6 family; regulates sterol uptake under anaerobic conditions along with SUT1; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; positively regulates mating along with SUT1 by repressing the expression of genes \(PRR2\, NCE102 and RHO5\) which function as mating inhibitors; SUT2 has a paralog\, SUT1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUT2" EXACT []

[Term]
id: sgd:S000006214
name: YPR010C
def: "RNA polymerase I second largest subunit A135" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "A135" EXACT []
synonym: "DNA-directed RNA polymerase I core subunit RPA135" EXACT []
synonym: "RPA135" EXACT []
synonym: "RPA2" EXACT []
synonym: "RRN2" EXACT []
synonym: "SRP3" EXACT []

[Term]
id: sgd:S000006215
name: YPR011C
def: "Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate \(APS\) and 3'-phospho-adenosine 5'-phosphosulfate \(PAPS\); member of the mitochondrial carrier family; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006216
name: YPR012W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YPR012W is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006217
name: YPR013C
def: "Putative zinc finger protein; YPR013C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMR3" EXACT []

[Term]
id: sgd:S000006218
name: YPR014C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; YPR014C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006219
name: YPR015C
def: "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006220
name: YPR016C
def: "Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 \(eIF6\); may be involved in the biogenesis and or stability of 60S ribosomal subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC95" EXACT []
synonym: "TIF6" EXACT []
synonym: "translation initiation factor 6" EXACT []

[Term]
id: sgd:S000006221
name: YPR017C
def: "Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc\, found both on membranes and in the cytosol" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSS4" EXACT []
synonym: "guanine nucleotide exchange factor DSS4" EXACT []

[Term]
id: sgd:S000006222
name: YPR018W
def: "Largest subunit \(p90\) of the Chromatin Assembly Complex \(CAF-1\); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres\, mating type loci\, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CAC1" EXACT []
synonym: "RLF2" EXACT []

[Term]
id: sgd:S000006223
name: YPR019W
def: "Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDC54" EXACT []
synonym: "HCD21" EXACT []
synonym: "MCM DNA helicase complex subunit MCM4" EXACT []
synonym: "MCM4" EXACT []

[Term]
id: sgd:S000006224
name: YPR020W
def: "Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex\, which in turn determines oligomerization of the complex and the shape of inner membrane cristae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP20" EXACT []
synonym: "F1F0 ATP synthase subunit g" EXACT []

[Term]
id: sgd:S000006225
name: YPR021C
def: "Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AGC1" EXACT []

[Term]
id: sgd:S000006226
name: YPR022C
def: "Putative transcription factor\, as suggested by computational analysis; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006227
name: YPR023C
def: "Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor\, nonessential component of the NuA4 acetyltransferase complex\, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EAF3" EXACT []

[Term]
id: sgd:S000006228
name: YPR024W
def: "Catalytic subunit of the i-AAA protease complex; complex is located in the mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as a nonconventional translocation motor to pull PNPase into the intermembrane space; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OSD1" EXACT []
synonym: "YME1" EXACT []
synonym: "YTA11" EXACT []
synonym: "i-AAA protease YME1" EXACT []

[Term]
id: sgd:S000006229
name: YPR025C
def: "Cyclin associated with protein kinase Kin28p; Kin28p is the TFIIH-associated carboxy-terminal domain \(CTD\) kinase involved in transcription initiation at RNA polymerase II promoters" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCL1" EXACT []
synonym: "TFIIH complex kinase subunit CCL1" EXACT []

[Term]
id: sgd:S000006230
name: YPR026W
def: "Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATH1" EXACT []
synonym: "alpha" EXACT []
synonym: "alpha-trehalase ATH1" EXACT []

[Term]
id: sgd:S000006231
name: YPR027C
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006232
name: YPR028W
def: "Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIP2" EXACT []
synonym: "YOP1" EXACT []

[Term]
id: sgd:S000006233
name: YPR029C
def: "Gamma-adaptin; large subunit of the clathrin-associated protein \(AP-1\) complex; binds clathrin; involved in vesicle mediated transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APL4" EXACT []

[Term]
id: sgd:S000006234
name: YPR030W
def: "Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p\, deubiquitinated by Ubp2p; CSR2 has a paralog\, ECM21\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ART8" EXACT []
synonym: "CSR2" EXACT []
synonym: "MRG19" EXACT []

[Term]
id: sgd:S000006235
name: YPR031W
def: "Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTO1" EXACT []

[Term]
id: sgd:S000006236
name: YPR032W
def: "Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog\, SRO77\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNI1" EXACT []
synonym: "SOP1" EXACT []
synonym: "SRO7" EXACT []

[Term]
id: sgd:S000006237
name: YPR033C
def: "Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTS1" EXACT []
synonym: "TS4572" EXACT []
synonym: "TSM4572" EXACT []
synonym: "histidine--tRNA ligase" EXACT []

[Term]
id: sgd:S000006238
name: YPR034W
def: "Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARP7" EXACT []
synonym: "RSC11" EXACT []
synonym: "SWP61" EXACT []

[Term]
id: sgd:S000006239
name: YPR035W
def: "Glutamine synthetase \(GS\); synthesizes glutamine from glutamate and ammonia; with Glt1p\, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH\, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GLN1" EXACT []
synonym: "glutamate--ammonia ligase" EXACT []

[Term]
id: sgd:S000006240
name: YPR036W
def: "Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase \(V-ATPase\) has eight subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CLS11" EXACT []
synonym: "H(+)-transporting V1 sector ATPase subunit H" EXACT []
synonym: "VMA13" EXACT []

[Term]
id: sgd:S000006241
name: YPR037C
def: "Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum \(ER\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERV2" EXACT []

[Term]
id: sgd:S000006242
name: YPR038W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IRC16" EXACT []

[Term]
id: sgd:S000006243
name: YPR039W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006244
name: YPR040W
def: "Protein that interacts with Tap42p\, which regulates PP2A; component of the TOR \(target of rapamycin\) signaling pathway; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIP41" EXACT []

[Term]
id: sgd:S000006245
name: YPR041W
def: "Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUI5" EXACT []
synonym: "TIF5" EXACT []
synonym: "translation initiation factor eIF5" EXACT []

[Term]
id: sgd:S000006246
name: YPR042C
def: "PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides\, separated by a 3-nt linker; PUF2 has a paralog\, JSN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PUF2" EXACT []

[Term]
id: sgd:S000006247
name: YPR043W
def: "Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A\, no bacterial homolog; RPL43A has a paralog\, RPL43B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L43A" EXACT []
synonym: "L43e" EXACT []
synonym: "RPL43A" EXACT []
synonym: "ribosomal 60S subunit protein L43A" EXACT []

[Term]
id: sgd:S000006248
name: YPR044C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; largely overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPI11" EXACT []

[Term]
id: sgd:S000006249
name: YPR045C
def: "Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MNI2" EXACT []
synonym: "THP3" EXACT []

[Term]
id: sgd:S000006250
name: YPR046W
def: "Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-H and fission yeast fta3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCM16" EXACT []

[Term]
id: sgd:S000006251
name: YPR047W
def: "Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer\, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSF1" EXACT []
synonym: "phenylalanine--tRNA ligase" EXACT []

[Term]
id: sgd:S000006252
name: YPR048W
def: "Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly \(CIA\) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAH18" EXACT []

[Term]
id: sgd:S000006253
name: YPR049C
def: "Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site \(PAS\) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATG11" EXACT []
synonym: "CVT3" EXACT []
synonym: "CVT9" EXACT []
synonym: "autophagy protein ATG11" EXACT []

[Term]
id: sgd:S000006254
name: YPR050C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006255
name: YPR051W
def: "Catalytic subunit of the NatC type N-terminal acetyltransferase; involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus \(Arl3p and Grh1p\) and the inner nuclear membrane \(Trm1p\); required for replication of dsRNA virus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MAK3" EXACT []
synonym: "NAA30" EXACT []

[Term]
id: sgd:S000006256
name: YPR052C
def: "High-mobility group \(HMG\) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog\, NHP6B\, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NHP6A" EXACT []

[Term]
id: sgd:S000006257
name: YPR053C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006258
name: YPR054W
def: "Middle sporulation-specific mitogen-activated protein kinase \(MAPK\); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMK1" EXACT []
synonym: "mitogen-activated protein kinase SMK1" EXACT []

[Term]
id: sgd:S000006259
name: YPR055W
def: "Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SEC8" EXACT []

[Term]
id: sgd:S000006260
name: YPR056W
def: "Subunit of TFIIH complex; involved in transcription initiation\, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFB4" EXACT []
synonym: "TFIIH/NER complex subunit TFB4" EXACT []

[Term]
id: sgd:S000006261
name: YPR057W
def: "snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BRR1" EXACT []

[Term]
id: sgd:S000006262
name: YPR058W
def: "Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier \(MCF\) family; localizes to vacuole in response to H2O2; YMC1 has a paralog\, YMC2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMC1" EXACT []

[Term]
id: sgd:S000006263
name: YPR059C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006264
name: YPR060C
def: "Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ARO7" EXACT []
synonym: "HGS1" EXACT []
synonym: "OSM2" EXACT []
synonym: "TYR7" EXACT []
synonym: "chorismate mutase ARO7" EXACT []

[Term]
id: sgd:S000006265
name: YPR061C
def: "Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JID1" EXACT []

[Term]
id: sgd:S000006266
name: YPR062W
def: "Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine \(5FC\) to form anticancer drug 5-fluorouracil \(5FU\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FCY1" EXACT []
synonym: "cytosine deaminase" EXACT []
synonym: "yCD" EXACT []

[Term]
id: sgd:S000006267
name: YPR063C
def: "ER-localized protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006268
name: YPR064W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006269
name: YPR065W
def: "Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "REO1" EXACT []
synonym: "ROX1" EXACT []

[Term]
id: sgd:S000006270
name: YPR066W
def: "Protein that activates Rub1p \(NEDD8\) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NEDD8-activating protein UBA3" EXACT []
synonym: "UBA3" EXACT []

[Term]
id: sgd:S000006271
name: YPR067W
def: "Protein required for maturation of mitochondrial \[4Fe-4S\] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space\, overexpression of ISA2 suppresses grx5 mutations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISA2" EXACT []

[Term]
id: sgd:S000006272
name: YPR068C
def: "Class I histone deacetylase \(HDAC\) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p\, Rpd3p\, Hos2p\, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CST3" EXACT []
synonym: "HOS1" EXACT []

[Term]
id: sgd:S000006273
name: YPR069C
def: "Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPE3" EXACT []
synonym: "spermidine synthase" EXACT []

[Term]
id: sgd:S000006274
name: YPR070W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED1" EXACT []

[Term]
id: sgd:S000006275
name: YPR071W
def: "Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog\, YIL029C\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006276
name: YPR072W
def: "Subunit of CCR4-NOT global transcriptional regulator; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCR4-NOT core subunit NOT5" EXACT []
synonym: "NOT5" EXACT []

[Term]
id: sgd:S000006277
name: YPR073C
def: "Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LTP1" EXACT []
synonym: "tyrosine protein phosphatase LTP1" EXACT []

[Term]
id: sgd:S000006278
name: YPR074C
def: "Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog\, TKL2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TKL1" EXACT []
synonym: "transketolase TKL1" EXACT []

[Term]
id: sgd:S000006279
name: YPR075C
def: "Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol \(HOG\) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPY2" EXACT []

[Term]
id: sgd:S000006280
name: YPR076W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006281
name: YPR077C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; expression increased by deletion of NAP1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006282
name: YPR078C
def: "Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006283
name: YPR079W
def: "Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRL1" EXACT []

[Term]
id: sgd:S000006284
name: YPR080W
def: "Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA \(AA-tRNA\) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF1 has a paralog\, TEF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EF-1 alpha" EXACT []
synonym: "TEF1" EXACT []
synonym: "eEF1A" EXACT []
synonym: "translation elongation factor EF-1 alpha" EXACT []

[Term]
id: sgd:S000006285
name: YPR081C
def: "Glycine-tRNA synthetase\, not expressed under normal growth conditions; expression is induced under heat\, oxidative\, pH\, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog\, GRS1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GRS2" EXACT []
synonym: "putative glycine--tRNA ligase" EXACT []

[Term]
id: sgd:S000006286
name: YPR082C
def: "17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing\, orthologue of hDIM1\, the human U5-specific 15-kDa protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DIB1" EXACT []
synonym: "SNU16" EXACT []

[Term]
id: sgd:S000006287
name: YPR083W
def: "Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor \(MECA\); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM36" EXACT []

[Term]
id: sgd:S000006288
name: YPR084W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006289
name: YPR085C
def: "Subunit of the ASTRA complex\, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASA1" EXACT []

[Term]
id: sgd:S000006290
name: YPR086W
def: "Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SOH4" EXACT []
synonym: "SUA7" EXACT []
synonym: "TFIIB" EXACT []

[Term]
id: sgd:S000006291
name: YPR087W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VPS69" EXACT []

[Term]
id: sgd:S000006292
name: YPR088C
def: "Signal recognition particle \(SRP\) subunit \(homolog of mammalian SRP54\); contains the signal sequence-binding activity of SRP\, interacts with the SRP RNA\, and mediates binding of SRP to signal receptor; contains GTPase domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SRH1" EXACT []
synonym: "SRP54" EXACT []

[Term]
id: sgd:S000006293
name: YPR089W
def: "Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YPR090W" EXACT []

[Term]
id: sgd:S000006295
name: YPR091C
def: "Lipid-binding ER protein\, enriched at nucleus-vacuolar junctions \(NVJ\); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein \(SMP\) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NVJ2" EXACT []

[Term]
id: sgd:S000006296
name: YPR092W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006297
name: YPR093C
def: "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASR1" EXACT []
synonym: "ubiquitin-protein ligase ASR1" EXACT []

[Term]
id: sgd:S000006298
name: YPR094W
def: "Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDS3" EXACT []

[Term]
id: sgd:S000006299
name: YPR095C
def: "Guanine nucleotide exchange factor \(GEF\) for Arf proteins; promotes activation of Arl1p\, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Arf family guanine nucleotide exchange factor SYT1" EXACT []
synonym: "SYT1" EXACT []

[Term]
id: sgd:S000006300
name: YPR096C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006301
name: YPR097W
def: "Protein that contains a PX domain and binds phosphoinositides; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; PX stands for Phox homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006302
name: YPR098C
def: "Protein of unknown function; localized to the mitochondrial outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006303
name: YPR099C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006304
name: YPR100W
def: "Mitochondrial ribosomal protein of the large subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRPL51" EXACT []
synonym: "mitochondrial 54S ribosomal protein MRPL51" EXACT []

[Term]
id: sgd:S000006305
name: YPR101W
def: "Member of the NineTeen Complex \(NTC\); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2\, U5\, and U6 snRNAs; interacts physically and genetically with Prp19p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NTC25" EXACT []
synonym: "SNT309" EXACT []

[Term]
id: sgd:S000006306
name: YPR102C
def: "Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog\, RPL11B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L11A" EXACT []
synonym: "L16B" EXACT []
synonym: "L5" EXACT []
synonym: "RPL11A" EXACT []
synonym: "YL22" EXACT []
synonym: "ribosomal 60S subunit protein L11A" EXACT []
synonym: "rp39A" EXACT []

[Term]
id: sgd:S000006307
name: YPR103W
def: "Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DOA3" EXACT []
synonym: "PRE2" EXACT []
synonym: "PRG1" EXACT []
synonym: "SRR2" EXACT []
synonym: "proteasome core particle subunit beta 5" EXACT []

[Term]
id: sgd:S000006308
name: YPR104C
def: "Regulator of ribosomal protein \(RP\) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "FHL1" EXACT []
synonym: "SPP42" EXACT []

[Term]
id: sgd:S000006309
name: YPR105C
def: "Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex \(Cog1p through Cog8p\) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COD1" EXACT []
synonym: "COG4" EXACT []
synonym: "SEC38" EXACT []
synonym: "SGF1" EXACT []

[Term]
id: sgd:S000006310
name: YPR106W
def: "Predicted protein kinase; overexpression causes sensitivity to staurosporine\, which is a potent inhibitor of protein kinase C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISR1" EXACT []
synonym: "putative protein kinase ISR1" EXACT []

[Term]
id: sgd:S000006311
name: YPR107C
def: "Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YTH1" EXACT []

[Term]
id: sgd:S000006312
name: YPR108W
def: "Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit\, Rpn5p\, as well as to mammalian proteasome subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPN7" EXACT []
synonym: "proteasome regulatory particle lid subunit RPN7" EXACT []

[Term]
id: sgd:S000006313
name: YPR109W
def: "Predicted membrane protein; diploid deletion strain has high budding index" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006314
name: YPR110C
def: "RNA polymerase subunit AC40; common to RNA polymerase I and III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DNA-directed RNA polymerase core subunit RPC40" EXACT []
synonym: "RPC40" EXACT []
synonym: "RPC5" EXACT []

[Term]
id: sgd:S000006315
name: YPR111W
def: "Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network \(MEN\) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog\, DBF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DBF20" EXACT []
synonym: "serine/threonine-protein kinase DBF20" EXACT []

[Term]
id: sgd:S000006316
name: YPR112C
def: "Essential conserved small ribosomal subunit \(40s\) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRD1" EXACT []

[Term]
id: sgd:S000006317
name: YPR113W
def: "Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol\, which is a precursor for polyphosphoinositides\, sphingolipids\, and glycolipid anchors for some of the plasma membrane proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CDP-diacylglycerol--inositol 3-phosphatidyltransferase" EXACT []
synonym: "PIS1" EXACT []

[Term]
id: sgd:S000006318
name: YPR114W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006319
name: YPR115W
def: "Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm; RGC1 has a paralog\, ASK10\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GCA1" EXACT []
synonym: "RGC1" EXACT []

[Term]
id: sgd:S000006320
name: YPR116W
def: "Putative protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRG8" EXACT []

[Term]
id: sgd:S000006321
name: YPR117W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSH1" EXACT []

[Term]
id: sgd:S000006322
name: YPR118W
def: "5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRI1" EXACT []
synonym: "S-methyl-5-thioribose-1-phosphate isomerase MRI1" EXACT []

[Term]
id: sgd:S000006323
name: YPR119W
def: "B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M\, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog\, CLB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB2" EXACT []
synonym: "CLB2" EXACT []

[Term]
id: sgd:S000006324
name: YPR120C
def: "B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog\, CLB6\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "B-type cyclin CLB5" EXACT []
synonym: "CLB5" EXACT []

[Term]
id: sgd:S000006325
name: YPR121W
def: "Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "THI22" EXACT []
synonym: "putative phosphomethylpyrimidine kinase" EXACT []

[Term]
id: sgd:S000006326
name: YPR122W
def: "Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AXL1" EXACT []
synonym: "FUS5" EXACT []
synonym: "STE22" EXACT []

[Term]
id: sgd:S000006327
name: YPR123C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006328
name: YPR124W
def: "High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CTR1" EXACT []

[Term]
id: sgd:S000006329
name: YPR125W
def: "Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1\, a protein implicated in Wolf-Hirschhorn syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRS7" EXACT []
synonym: "YLH47" EXACT []

[Term]
id: sgd:S000006330
name: YPR126C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006331
name: YPR127W
def: "Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein \(GFP\)-fusion protein localizes to both the cytoplasm and the nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "pyridoxine 4-dehydrogenase" EXACT []

[Term]
id: sgd:S000006332
name: YPR128C
def: "Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ANT1" EXACT []

[Term]
id: sgd:S000006333
name: YPR129W
def: "Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM13" EXACT []
synonym: "SCD6" EXACT []

[Term]
id: sgd:S000006334
name: YPR130C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006335
name: YPR131C
def: "Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAA20" EXACT []
synonym: "NAT3" EXACT []
synonym: "RAD56" EXACT []

[Term]
id: sgd:S000006336
name: YPR132W
def: "Ribosomal protein 28 \(rp28\) of the small \(40S\) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog\, RPS23A\, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPS23B" EXACT []
synonym: "S12" EXACT []
synonym: "S23B" EXACT []
synonym: "S28B" EXACT []
synonym: "YS14" EXACT []
synonym: "ribosomal 40S subunit protein S23B" EXACT []
synonym: "rp37" EXACT []

[Term]
id: sgd:S000006337
name: YPR133C
def: "Protein involved in RNA polymerase II transcription; is constitutively recruited to the CYC1 promoter and is required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II\, TBP\, TFIIS\, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IWS1" EXACT []
synonym: "SPN1" EXACT []

[Term]
id: sgd:S000006338
name: YPR134W
def: "Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MSS18" EXACT []

[Term]
id: sgd:S000006339
name: YPR135W
def: "Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha \(Pol1p\) and may link DNA synthesis to sister chromatid cohesion" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHL15" EXACT []
synonym: "CTF4" EXACT []
synonym: "POB1" EXACT []
synonym: "chromatin-binding protein CTF4" EXACT []

[Term]
id: sgd:S000006340
name: YPR136C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006341
name: YPR137W
def: "Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit \(SSU\) processosome; ortholog of the human U3-55k protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP9" EXACT []

[Term]
id: sgd:S000006342
name: YPR138C
def: "Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium \(NH4+\); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog\, MEP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MEP3" EXACT []
synonym: "ammonium permease MEP3" EXACT []

[Term]
id: sgd:S000006343
name: YPR139C
def: "Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LOA1" EXACT []
synonym: "VPS66" EXACT []
synonym: "lysophosphatidic acid acyltransferase LOA1" EXACT []

[Term]
id: sgd:S000006344
name: YPR140W
def: "Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin cause Barth syndrome\, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAZ1" EXACT []

[Term]
id: sgd:S000006345
name: YPR141C
def: "Minus-end-directed microtubule motor; functions in mitosis and meiosis\, localizes to the spindle pole body and localization is dependent on functional Cik1p\, required for nuclear fusion during mating; potential Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KAR3" EXACT []
synonym: "OSR11" EXACT []

[Term]
id: sgd:S000006346
name: YPR142C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15\, which is required for ribosomal RNA processing" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006347
name: YPR143W
def: "Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRP15" EXACT []

[Term]
id: sgd:S000006348
name: YPR144C
def: "Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOC4" EXACT []
synonym: "UTP19" EXACT []

[Term]
id: sgd:S000006349
name: YPR145W
def: "Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog\, ASN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ASN1" EXACT []
synonym: "asparagine synthase (glutamine-hydrolyzing) 1" EXACT []

[Term]
id: sgd:S000006350
name: YPR146C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006351
name: YPR147C
def: "Putative protein of unknown function; may have a role in lipid metabolism\, based on localization to lipid droplets; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006352
name: YPR148C
def: "Protein of unknown function; may interact with ribosomes\, based on co-purification experiments; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006353
name: YPR149W
def: "Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes \(DIGs\); NCE102 has a paralog\, FHN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCE102" EXACT []
synonym: "NCE2" EXACT []

[Term]
id: sgd:S000006354
name: YPR150W
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006355
name: YPR151C
def: "Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUE1" EXACT []

[Term]
id: sgd:S000006356
name: YPR152C
def: "Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "URN1" EXACT []

[Term]
id: sgd:S000006357
name: YPR153W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006358
name: YPR154W
def: "Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p\, a homolog of human Wiskott-Aldrich Syndrome protein \(WASP\)\, via an N-terminal SH3 domain\, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the \[PIN+\] and \[RNQ+\] prions when overproduced; PIN3 has a paralog\, LSB1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSB2" EXACT []
synonym: "PIN3" EXACT []

[Term]
id: sgd:S000006359
name: YPR155C
def: "Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 \(Atp6p\) and 8 \(Atp8p\) of the Fo-F1 ATP synthase; functions with Nca3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NCA2" EXACT []

[Term]
id: sgd:S000006360
name: YPR156C
def: "Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug\:H\(+\) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog\, TPO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TPO3" EXACT []

[Term]
id: sgd:S000006361
name: YPR157W
def: "Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; TDA6 has a paralog\, VPS62\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TDA6" EXACT []

[Term]
id: sgd:S000006362
name: YPR158W
def: "Sorting factor\, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of \[URE3\] prions; CUR1 has a paralog\, BTN2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CUR1" EXACT []

[Term]
id: sgd:S000006363
name: YPR159W
def: "Type II integral membrane protein; required for beta-1\,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER\, plasma membrane\, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog\, SKN1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH48" EXACT []
synonym: "KRE6" EXACT []
synonym: "beta-glucan synthesis-associated protein KRE6" EXACT []

[Term]
id: sgd:S000006364
name: YPR160W
def: "Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; expression is regulated by stress-response elements and by the HOG MAP kinase pathway" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GPH1" EXACT []

[Term]
id: sgd:S000006365
name: YPR161C
def: "Cyclin \(Bur2p\)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal domain \(CTD\) of Rpo21p and the C-terminal repeat domain of Spt5p; recruits Spt6p to the CTD at the onset of transcription; regulated by Cak1p; similar to metazoan CDK9 proteins" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUR1" EXACT []
synonym: "SGV1" EXACT []
synonym: "cyclin-dependent serine/threonine protein kinase SGV1" EXACT []

[Term]
id: sgd:S000006366
name: YPR162C
def: "Subunit of the origin recognition complex \(ORC\); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog\, RIF2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORC4" EXACT []
synonym: "origin recognition complex subunit 4" EXACT []

[Term]
id: sgd:S000006367
name: YPR163C
def: "Translation initiation factor eIF-4B; contains an RNA recognition motif and binds to single-stranded RNA; has RNA annealing activity; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBL3" EXACT []
synonym: "STM1" EXACT []
synonym: "TIF3" EXACT []
synonym: "eIF4B" EXACT []

[Term]
id: sgd:S000006368
name: YPR164W
def: "Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase\, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MMS1" EXACT []
synonym: "RTT108" EXACT []
synonym: "SLM6" EXACT []

[Term]
id: sgd:S000006369
name: YPR165W
def: "GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C \(Pkc1p\) and the cell wall synthesizing enzyme 1\,3-beta-glucan synthase \(Fks1p and Gsc2p\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RHO1" EXACT []
synonym: "Rho family GTPase RHO1" EXACT []

[Term]
id: sgd:S000006370
name: YPR166C
def: "Mitochondrial ribosomal protein of the small subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP2" EXACT []
synonym: "mitochondrial 37S ribosomal protein MRP2" EXACT []

[Term]
id: sgd:S000006371
name: YPR167C
def: "3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3'\,5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate\, involved in sulfate assimilation and methionine metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MET16" EXACT []
synonym: "phosphoadenylyl-sulfate reductase (thioredoxin)" EXACT []

[Term]
id: sgd:S000006372
name: YPR168W
def: "Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MED10" EXACT []
synonym: "NUT2" EXACT []

[Term]
id: sgd:S000006373
name: YPR169W
def: "Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing\, ribosome biogenesis\, ubiquitination and demethylation; similar to WDR55\, a human WD repeat protein; essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "JIP5" EXACT []

[Term]
id: sgd:S000006374
name: YPR170C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORFs YPR169W-A and YPR170W-B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006375
name: YPR171W
def: "Adapter that links synaptojanins to the cortical actin cytoskeleton; the synaptojanins are Inp52p and Inp53p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BSP1" EXACT []

[Term]
id: sgd:S000006376
name: YPR172W
def: "Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog\, YLR456W\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "pyridoxal 5'-phosphate synthase" EXACT []

[Term]
id: sgd:S000006377
name: YPR173C
def: "AAA-ATPase involved in multivesicular body \(MVB\) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAA family ATPase VPS4" EXACT []
synonym: "CSC1" EXACT []
synonym: "DID6" EXACT []
synonym: "END13" EXACT []
synonym: "GRD13" EXACT []
synonym: "VPL4" EXACT []
synonym: "VPS4" EXACT []
synonym: "VPT10" EXACT []

[Term]
id: sgd:S000006378
name: YPR174C
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog\, NBP1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006379
name: YPR175W
def: "Second largest subunit of DNA polymerase II \(DNA polymerase epsilon\); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPB2" EXACT []

[Term]
id: sgd:S000006380
name: YPR176C
def: "Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BET2" EXACT []

[Term]
id: sgd:S000006381
name: YPR177C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006382
name: YPR178W
def: "Splicing factor; component of the U4/U6-U5 snRNP complex" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PRP4" EXACT []
synonym: "RNA4" EXACT []

[Term]
id: sgd:S000006383
name: YPR179C
def: "Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HDA3" EXACT []
synonym: "PLO1" EXACT []

[Term]
id: sgd:S000006384
name: YPR180W
def: "Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p \(SUMO\) before its conjugation to proteins \(sumoylation\)\, which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AOS1" EXACT []
synonym: "E1 ubiquitin-activating protein AOS1" EXACT []
synonym: "RHC31" EXACT []

[Term]
id: sgd:S000006385
name: YPR181C
def: "GTPase-activating protein\, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat\, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GTPase-activating protein SEC23" EXACT []
synonym: "SEC23" EXACT []

[Term]
id: sgd:S000006386
name: YPR182W
def: "Core Sm protein Sm F; part of heteroheptameric complex \(with Smb1p\, Smd1p\, Smd2p\, Smd3p\, Sme1p\, and Smx2p\) that is part of the spliceosomal U1\, U2\, U4\, and U5 snRNPs; homolog of human Sm F" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SMX3" EXACT []
synonym: "Sm F" EXACT []
synonym: "SmF" EXACT []

[Term]
id: sgd:S000006387
name: YPR183W
def: "Dolichol phosphate mannose \(Dol-P-Man\) synthase of the ER membrane; catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring\, O mannosylation\, and protein glycosylation" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPM1" EXACT []
synonym: "SED3" EXACT []
synonym: "dolichyl-phosphate beta-D-mannosyltransferase" EXACT []

[Term]
id: sgd:S000006388
name: YPR184W
def: "Glycogen debranching enzyme; contains glucanotranferase and alpha-1\,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "6-glucosidase" EXACT []
synonym: "GDB1" EXACT []
synonym: "bifunctional 4-alpha-glucanotransferase/amylo-alpha-1" EXACT []

[Term]
id: sgd:S000006389
name: YPR185W
def: "Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting \(Cvt\) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "APG13" EXACT []
synonym: "ATG13" EXACT []
synonym: "serine/threonine protein kinase regulatory subunit ATG13" EXACT []

[Term]
id: sgd:S000006390
name: YPR186C
def: "Transcription factor IIIA \(TFIIIA\); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PZF1" EXACT []
synonym: "TFC2" EXACT []

[Term]
id: sgd:S000006391
name: YPR187W
def: "RNA polymerase subunit ABC23; common to RNA polymerases I\, II\, and III; part of central core; similar to bacterial omega subunit" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ABC23" EXACT []
synonym: "DNA-directed RNA polymerase core subunit RPB6" EXACT []
synonym: "RPB6" EXACT []
synonym: "RPO26" EXACT []

[Term]
id: sgd:S000006392
name: YPR188C
def: "Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p\, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MLC2" EXACT []

[Term]
id: sgd:S000006393
name: YPR189W
def: "Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog\, TTC37\, causes Syndromic diarrhea/Trichohepatoenteric \(SD/THE\) syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SKI complex subunit tetratricopeptide repeat protein SKI3" EXACT []
synonym: "SKI3" EXACT []
synonym: "SKI5" EXACT []

[Term]
id: sgd:S000006394
name: YPR190C
def: "RNA polymerase III subunit C82" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RPC3" EXACT []
synonym: "RPC80" EXACT []
synonym: "RPC82" EXACT []

[Term]
id: sgd:S000006395
name: YPR191W
def: "Subunit 2 of ubiquinol cytochrome-c reductase \(Complex III\); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p\, Hap2p/Hap3p\, and heme" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COR2" EXACT []
synonym: "QCR2" EXACT []
synonym: "UCR2" EXACT []
synonym: "ubiquinol--cytochrome-c reductase subunit 2" EXACT []

[Term]
id: sgd:S000006396
name: YPR192W
def: "Spore-specific water channel; mediates the transport of water across cell membranes\, developmentally controlled; may play a role in spore maturation\, probably by allowing water outflow\, may be involved in freeze tolerance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AQY1" EXACT []

[Term]
id: sgd:S000006397
name: YPR193C
def: "Tetrameric histone acetyltransferase; has similarity to Gcn5p\, Hat1p\, Elp3p\, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HPA2" EXACT []
synonym: "KAT10" EXACT []

[Term]
id: sgd:S000006398
name: YPR194C
def: "Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane \(PM\) and to the late Golgi\, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family\, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "OPT2" EXACT []

[Term]
id: sgd:S000006399
name: YPR195C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006400
name: YPR196W
def: "Putative maltose-responsive transcription factor" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "putative maltose-responsive transcription factor" EXACT []

[Term]
id: sgd:S000006401
name: YPR197C
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF SGE1/YPR198W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006402
name: YPR198W
def: "Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOR1" EXACT []
synonym: "SGE1" EXACT []

[Term]
id: sgd:S000006403
name: YPR199C
def: "Transcriptional activator of the basic leucine zipper \(bZIP\) family; required for transcription of genes involved in resistance to arsenic compounds" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACR1" EXACT []
synonym: "ARR1" EXACT []
synonym: "YAP8" EXACT []

[Term]
id: sgd:S000006404
name: YPR200C
def: "Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACR2" EXACT []
synonym: "ARR2" EXACT []

[Term]
id: sgd:S000006405
name: YPR201W
def: "Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ACR3" EXACT []
synonym: "ARR3" EXACT []

[Term]
id: sgd:S000006406
name: YPR202W
def: "Putative protein of unknown function; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006407
name: YPR203W
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006408
name: YPR204W
def: "DNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' -Help1" EXACT []
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000006409
name: YEL077C
def: "Helicase-like protein encoded within the telomeric Y' element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase" EXACT []

[Term]
id: sgd:S000006429
name: YLR390W-A
def: "Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CCW14" EXACT []
synonym: "ICWP" EXACT []
synonym: "SSR1" EXACT []
synonym: "YLR391W" EXACT []
synonym: "YLR391W-A" EXACT []

[Term]
id: sgd:S000006430
name: YDL045W-A
def: "Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MRP10" EXACT []
synonym: "YmS-T" EXACT []
synonym: "mitochondrial 37S ribosomal protein YmS-T" EXACT []

[Term]
id: sgd:S000006431
name: YOR008C-A
def: "Putative protein of unknown function; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000006432
name: YIL009C-A
def: "Component of the telomerase holoenzyme; involved in telomere replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EST3" EXACT []
synonym: "telomerase subunit EST3" EXACT []

[Term]
id: sgd:S000006433
name: YPR133W-A
def: "Component of the TOM \(translocase of outer membrane\) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MOM8A" EXACT []
synonym: "TOM5" EXACT []

[Term]
id: sgd:S000006434
name: YLR438C-A
def: "Lsm \(Like Sm\) protein; part of heteroheptameric complexes \(Lsm2p-7p and either Lsm1p or 8p\)\: cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA\, snoRNA\, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSM3" EXACT []
synonym: "SMX4" EXACT []
synonym: "USS2" EXACT []

[Term]
id: sgd:S000006435
name: YKR035W-A
def: "Class E protein of the vacuolar protein-sorting \(Vps\) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CHM1" EXACT []
synonym: "DID2" EXACT []
synonym: "FTI1" EXACT []
synonym: "VPL30" EXACT []
synonym: "VPS46" EXACT []

[Term]
id: sgd:S000006436
name: YFL034C-A
def: "Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22\, no bacterial homolog; RPL22B has a paralog\, RPL22A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L22B" EXACT []
synonym: "L22e" EXACT []
synonym: "RPL22B" EXACT []
synonym: "YFL035C-B" EXACT []
synonym: "YL31" EXACT []
synonym: "l1c" EXACT []
synonym: "ribosomal 60S subunit protein L22B" EXACT []
synonym: "rp4" EXACT []

[Term]
id: sgd:S000006437
name: YFR032C-A
def: "Ribosomal 60S subunit protein L29; not essential for translation\, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29\, no bacterial homolog" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L29" EXACT []
synonym: "L29e" EXACT []
synonym: "RPL29" EXACT []
synonym: "YL43" EXACT []
synonym: "ribosomal 60S subunit protein L29" EXACT []

[Term]
id: sgd:S000006438
name: YPL249C-A
def: "Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36\, no bacterial homolog; RPL36B has a paralog\, RPL36A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "L36B" EXACT []
synonym: "L36e" EXACT []
synonym: "L39" EXACT []
synonym: "RPL36B" EXACT []
synonym: "YL39" EXACT []
synonym: "ribosomal 60S subunit protein L36B" EXACT []

[Term]
id: sgd:S000006439
name: YCR020W-B
def: "Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation\, chromosome stability\, and establishing sister chromatid cohesion; involved in telomere maintenance" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HTL1" EXACT []

[Term]
id: sgd:S000007221
name: YCL001W-A
def: "Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007222
name: YCR028C-A
def: "ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RIM1" EXACT []

[Term]
id: sgd:S000007223
name: YCR087C-A
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LUG1" EXACT []

[Term]
id: sgd:S000007224
name: YPL183W-A
def: "Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36\, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "GON5" EXACT []
synonym: "RTC6" EXACT []
synonym: "TAE4" EXACT []
synonym: "putative mitochondrial 54S ribosomal protein RTC6" EXACT []

[Term]
id: sgd:S000007226
name: YER039C-A
def: "Putative protein of unknown function; YER039C-A is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007228
name: YBL091C-A
def: "Protein involved in regulation of phospholipid metabolism; one of 6 proteins \(Ist2p\, Scs2p\, Scs22p\, Tcb1p\, Tcb2p\, Tcb3p\) that connect ER to the plasma membrane \(PM\) and regulate PM phosphatidylinositol-4-phosphate \(PI4P\) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog\, SCS2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SCS22" EXACT []
synonym: "phospholipid metabolism-regulating protein SCS22" EXACT []

[Term]
id: sgd:S000007229
name: YBL107W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2; YBL107W-A has a paralog\, YER138W-A\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007230
name: YCR018C-A
def: "Putative protein of unknown function; encoded opposite a Ty1 LTR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007231
name: YCR102W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007232
name: YDL130W-A
def: "Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog\, INH1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AIS2" EXACT []
synonym: "STF1" EXACT []

[Term]
id: sgd:S000007233
name: YDR034C-A
def: "Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007234
name: YDR034W-B
def: "Predicted tail-anchored plasma membrane protein; contains conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery; YDR034W-B has a paralog\, YBR056W-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007235
name: YDR363W-A
def: "Component of lid subcomplex of 26S proteasome regulatory subunit; involved in mRNA export mediated by TREX-2 complex \(Sac3p-Thp1p\); assumes different conformations in different contexts\, functions as molecular glue stabilizing the Rpn3p/Rpn7p regulatory heterodimer\, and tethers it to lid helical bundle; ortholog of human DSS1; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DSS1" EXACT []
synonym: "HOD1" EXACT []
synonym: "SEM1" EXACT []
synonym: "proteasome regulatory particle lid subunit SEM1" EXACT []

[Term]
id: sgd:S000007236
name: YDR525W-A
def: "Protein of unknown function; has similarity to Pmp3p\, which is involved in cation transport; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm in a punctate pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SNA2" EXACT []

[Term]
id: sgd:S000007237
name: YER048W-A
def: "Cysteine desulfurase \(Nfs1p\) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes\, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster \(ISC\) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ISD11" EXACT []

[Term]
id: sgd:S000007238
name: YER091C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007239
name: YER138W-A
def: "Putative protein of unknown function; YER138W-A has a paralog\, YBL107W-A\, that arose from a single-locus duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007240
name: YGR122C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; similar to YLR334C and YOL106W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007241
name: YIR020W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YIR020W-B" EXACT []

[Term]
id: sgd:S000007242
name: YKL033W-A
def: "Putative protein of unknown function; similar to uncharacterized proteins from other fungi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007243
name: YKL053C-A
def: "Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MDM35" EXACT []

[Term]
id: sgd:S000007244
name: YKL162C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007245
name: YLL018C-A
def: "Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX19" EXACT []

[Term]
id: sgd:S000007246
name: YLR262C-A
def: "Protein of unknown that associates with ribosomes; null mutant exhibits translation defects\, altered polyribosome profiles\, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RBF7" EXACT []
synonym: "TMA7" EXACT []

[Term]
id: sgd:S000007247
name: YML081C-A
def: "Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP18" EXACT []
synonym: "F1F0 ATP synthase subunit i" EXACT []

[Term]
id: sgd:S000007248
name: YMR046W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007249
name: YMR158C-A
def: "Putative protein of unknown function; may contain a lipid attachment site; YMR158C-A is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YMR158C-B" EXACT []

[Term]
id: sgd:S000007250
name: YMR194C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007251
name: YNR032C-A
def: "Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66\, may function in modification of Sph1p and Hbt1p\, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUB1" EXACT []

[Term]
id: sgd:S000007252
name: YOL013W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat \(LTR\) of a Ty1 element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOL013W-A" EXACT []

[Term]
id: sgd:S000007253
name: YOR298C-A
def: "Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MBF1" EXACT []
synonym: "SUF13" EXACT []

[Term]
id: sgd:S000007254
name: YPR002C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat\, YPRWdelta12" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007255
name: YDR322C-A
def: "Subunit e of mitochondrial F1F0-ATPase; ATPase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase\, which in turn determines the shape of inner membrane cristae" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP21" EXACT []
synonym: "F1F0 ATP synthase subunit e" EXACT []
synonym: "TIM11" EXACT []

[Term]
id: sgd:S000007256
name: YEL020W-A
def: "Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p \(TIM10 complex\) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM9" EXACT []
synonym: "protein transporter TIM9" EXACT []

[Term]
id: sgd:S000007257
name: Q0010
def: "Dubious open reading frame; unlikely to encode a protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0017" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF6" EXACT []

[Term]
id: sgd:S000007258
name: Q0017
def: "Dubious open reading frame; unlikely to encode a protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0010" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF7" EXACT []

[Term]
id: sgd:S000007259
name: Q0032
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF8" EXACT []

[Term]
id: sgd:S000007260
name: Q0045
def: "Subunit I of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX1" EXACT []
synonym: "OXI3" EXACT []
synonym: "cytochrome c oxidase subunit 1" EXACT []

[Term]
id: sgd:S000007261
name: Q0050
def: "Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI1" EXACT []
synonym: "intron-encoded reverse transcriptase aI1" EXACT []

[Term]
id: sgd:S000007262
name: Q0055
def: "Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI2" EXACT []
synonym: "intron-encoded reverse transcriptase aI2" EXACT []

[Term]
id: sgd:S000007263
name: Q0060
def: "Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI3" EXACT []
synonym: "I-SceIII" EXACT []
synonym: "intron-encoded DNA endonuclease aI3" EXACT []

[Term]
id: sgd:S000007264
name: Q0065
def: "Endonuclease I-SceII; encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI4" EXACT []
synonym: "I-SceII" EXACT []
synonym: "intron-encoded DNA endonuclease aI4" EXACT []

[Term]
id: sgd:S000007265
name: Q0070
def: "Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI5_ALPHA" EXACT []
synonym: "intron-encoded DNA endonuclease aI5 alpha" EXACT []

[Term]
id: sgd:S000007266
name: Q0075
def: "Protein of unknown function; encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AI5_BETA" EXACT []
synonym: "intron-encoded DNA endonuclease aI5 beta" EXACT []

[Term]
id: sgd:S000007267
name: Q0080
def: "Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase; encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "AAP1" EXACT []
synonym: "ATP8" EXACT []
synonym: "F1F0 ATP synthase subunit 8" EXACT []

[Term]
id: sgd:S000007268
name: Q0085
def: "Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrially encoded; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP6" EXACT []
synonym: "F1F0 ATP synthase subunit a" EXACT []
synonym: "OLI2" EXACT []
synonym: "OLI4" EXACT []
synonym: "PHO1" EXACT []

[Term]
id: sgd:S000007269
name: Q0092
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF5" EXACT []

[Term]
id: sgd:S000007270
name: Q0105
def: "Cytochrome b; mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp\, Rip1p\, Cyt1p\, Cor1p\, Qcr2p\, Qcr6p\, Qcr7p\, Qcr8p\, Qcr9p\, and Qcr10p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COB" EXACT []
synonym: "COB1" EXACT []
synonym: "CYTB" EXACT []
synonym: "cytochrome b" EXACT []

[Term]
id: sgd:S000007271
name: Q0110
def: "Mitochondrial mRNA maturase with a role in splicing; encoded by both exon and intron sequences of partially processed COB mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BI2" EXACT []
synonym: "cytochrome b mRNA maturase bI2" EXACT []

[Term]
id: sgd:S000007272
name: Q0115
def: "Mitochondrial mRNA maturase; forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BI3" EXACT []
synonym: "cytochrome b mRNA maturase bI3" EXACT []

[Term]
id: sgd:S000007273
name: Q0120
def: "Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BI4" EXACT []
synonym: "intron-encoded RNA maturase bI4" EXACT []

[Term]
id: sgd:S000007274
name: Q0130
def: "F0-ATP synthase subunit c \(ATPase-associated proteolipid\); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP9" EXACT []
synonym: "F0 ATP synthase subunit c" EXACT []
synonym: "OLI1" EXACT []
synonym: "OLI3" EXACT []

[Term]
id: sgd:S000007275
name: Q0140
def: "Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT \(asparagine\) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "VAR1" EXACT []
synonym: "VARI" EXACT []
synonym: "mitochondrial 37S ribosomal protein VAR1" EXACT []

[Term]
id: sgd:S000007276
name: Q0142
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps dubious open reading frame Q0143" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF9" EXACT []

[Term]
id: sgd:S000007277
name: Q0143
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF10" EXACT []

[Term]
id: sgd:S000007278
name: Q0144
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007279
name: Q0160
def: "I-SceI DNA endonuclease; encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "I-SceIV" EXACT []
synonym: "OMEGA" EXACT []
synonym: "SCEI" EXACT []
synonym: "intron-encoded endonuclease I-SceI" EXACT []

[Term]
id: sgd:S000007280
name: Q0182
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF11" EXACT []

[Term]
id: sgd:S000007281
name: Q0250
def: "Subunit II of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX2" EXACT []
synonym: "OXI1" EXACT []
synonym: "OXII" EXACT []
synonym: "cytochrome c oxidase subunit 2" EXACT []

[Term]
id: sgd:S000007282
name: Q0255
def: "Maturase-like protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF1" EXACT []
synonym: "RF1" EXACT []
synonym: "maturase-like protein" EXACT []

[Term]
id: sgd:S000007283
name: Q0275
def: "Subunit III of cytochrome c oxidase \(Complex IV\); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX3" EXACT []
synonym: "OXI2" EXACT []
synonym: "cytochrome c oxidase subunit 3" EXACT []

[Term]
id: sgd:S000007284
name: Q0297
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene RPM1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ORF12" EXACT []

[Term]
id: sgd:S000007339
name: YOL077W-A
def: "Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large\, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ATP19" EXACT []
synonym: "F1F0 ATP synthase subunit k" EXACT []

[Term]
id: sgd:S000007348
name: YJR135W-A
def: "Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A\, implicated in Mohr-Tranebjaerg syndrome" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TIM8" EXACT []
synonym: "protein transporter TIM8" EXACT []

[Term]
id: sgd:S000007455
name: YHR072W-A
def: "Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NOP10" EXACT []

[Term]
id: sgd:S000007472
name: YML058W-A
def: "Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HUG1" EXACT []

[Term]
id: sgd:S000007488
name: YBL059C-A
def: "Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMC2" EXACT []

[Term]
id: sgd:S000007496
name: YHR132W-A
def: "Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog\, IGO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "IGO2" EXACT []

[Term]
id: sgd:S000007521
name: YBR058C-A
def: "Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TSC3" EXACT []

[Term]
id: sgd:S000007522
name: YBR085C-A
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007523
name: YER053C-A
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007524
name: YMR122W-A
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and endoplasmic reticulum" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007525
name: YNR034W-A
def: "Putative protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog\, YCR075W-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007526
name: YOR396W
def: "One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 \(Y'-HELicase Protein 1\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "Y' element ATP-dependent helicase protein 1 copy 8" EXACT []
synonym: "YRF1-8" EXACT []

[Term]
id: sgd:S000007547
name: YCL057C-A
def: "Conserved component of the MICOS complex; MICOS \(formerly MINOS or MitOS\) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions\, inner membrane architecture\, and formation of contact sites to the outer membrane; ortholog of human MINOS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCS10" EXACT []
synonym: "MIC10" EXACT []
synonym: "MIO10" EXACT []
synonym: "MOS1" EXACT []

[Term]
id: sgd:S000007548
name: YCL026C-B
def: "Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HBN1" EXACT []
synonym: "YCL027C-A" EXACT []

[Term]
id: sgd:S000007549
name: YCL021W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007586
name: YAL044W-A
def: "Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007587
name: YBL071W-A
def: "Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p\, Elp2p\, and Elp3p; involved in modification of wobble nucleosides in tRNAs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DPH3" EXACT []
synonym: "KTI11" EXACT []

[Term]
id: sgd:S000007588
name: YDL085C-A
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm and nucleus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007590
name: YER014C-A
def: "Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "BUD25" EXACT []

[Term]
id: sgd:S000007591
name: YBL029C-A
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007592
name: YBL108C-A
def: "Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PAU9" EXACT []
synonym: "seripauperin PAU9" EXACT []

[Term]
id: sgd:S000007593
name: YBR103C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by homology to related yeast" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007594
name: YBR191W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007595
name: YBR233W-A
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAD3" EXACT []

[Term]
id: sgd:S000007596
name: YCL001W-B
def: "Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog\, DOM34\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007597
name: YCR038W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007598
name: YDL114W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007599
name: YDL159W-A
def: "Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDL159W-B" EXACT []

[Term]
id: sgd:S000007600
name: YDL185C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007601
name: YDL240C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007602
name: YDL247W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007603
name: YDR079C-A
def: "Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TFB5" EXACT []
synonym: "TFIIH complex subunit TFB5" EXACT []

[Term]
id: sgd:S000007604
name: YDR320C-A
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DAD4" EXACT []
synonym: "HSK2" EXACT []

[Term]
id: sgd:S000007605
name: YDR379C-A
def: "Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SDH6" EXACT []

[Term]
id: sgd:S000007606
name: YFR012W-A
def: "Putative protein of unknown function; identified by homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007607
name: YGL258W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007608
name: YGR271C-A
def: "Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleolus" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "EFG1" EXACT []
synonym: "YGR272C" EXACT []

[Term]
id: sgd:S000007610
name: YJL052C-A
def: "Putative protein of unknown function; identified based on comparison to related yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007611
name: YJL062W-A
def: "Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COA3" EXACT []
synonym: "COX25" EXACT []
synonym: "RRG10" EXACT []

[Term]
id: sgd:S000007612
name: YJL127W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YJL127W-B" EXACT []

[Term]
id: sgd:S000007613
name: YJL156W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007615
name: YKL018C-A
def: "Putative protein of unknown function; identified by homology; green fluorescent protein \(GFP\)-fusion protein localizes to the cytoplasm" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007616
name: YKL106C-A
def: "Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007617
name: YKL165C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007618
name: YLR099W-A
def: "Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments\, including Ugo1p\, Tom20p\, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p; not essential in W303 strain background" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MIM2" EXACT []

[Term]
id: sgd:S000007619
name: YLR149C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007620
name: YLR363W-A
def: "Protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007621
name: YML007C-A
def: "Putative protein of unknown function; green fluorescent protein \(GFP\)-fusion protein localizes to mitochondria" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007622
name: YMR013W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007623
name: YNL067W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YNL067W-B" EXACT []

[Term]
id: sgd:S000007624
name: YNL162W-A
def: "Putative protein of unknown function; identified by homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007625
name: YNR001W-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007626
name: YOL086W-A
def: "Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM\, a Fanconi anemia complementation group protein\, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network \(CCAN\) subunit CENP-S\, also known as MHF1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHF1" EXACT []

[Term]
id: sgd:S000007627
name: YOL159C-A
def: "Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007628
name: YOR008W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007629
name: YOR314W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007630
name: YPR016W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007631
name: YPR074W-A
def: "Hypothetical protein identified by homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007632
name: YCR097W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007649
name: YBR255C-A
def: "Putative protein of unknown function; may interact with respiratory chain complexes III \(ubiquinol-cytochrome c reductase\) or IV \(cytochrome c oxidase\); identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007650
name: YDR381C-A
def: "Protein of unknown function; localized to the mitochondrial outer membrane" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000007651
name: YER074W-A
def: "Integral membrane protein required for ER to Golgi transport; localized to the Golgi\, the ER\, and COPII vesicles; interacts with Yip1p and Yif1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOS1" EXACT []

[Term]
id: sgd:S000028421
name: YKL138C-A
def: "Essential subunit of the Dam1 complex \(aka DASH complex\); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HSK3" EXACT []

[Term]
id: sgd:S000028422
name: YLR154W-C
def: "Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "TAR1" EXACT []
synonym: "YLR154W-A" EXACT []

[Term]
id: sgd:S000028423
name: YPL096C-A
def: "Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum \(ER\); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ERI1" EXACT []
synonym: "RIN1" EXACT []

[Term]
id: sgd:S000028425
name: YPR036W-A
def: "Small \(67 amino acids\) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer\, 5'-extended mRNA is also transcribed beginning in mid-meiosis\, regulated by two MSEs \(middle sporulation elements\)\, and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SPO24" EXACT []

[Term]
id: sgd:S000028437
name: YER180C-A
def: "Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SLO1" EXACT []

[Term]
id: sgd:S000028508
name: YCL005W-A
def: "Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CWH36" EXACT []
synonym: "H(+)-transporting V0 sector ATPase subunit e" EXACT []
synonym: "LDB10" EXACT []
synonym: "VMA9" EXACT []

[Term]
id: sgd:S000028509
name: YNL138W-A
def: "Component of the SF3b subcomplex of the U2 snRNP; essential protein required for for splicing and for assembly of SF3b" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RCP10" EXACT []
synonym: "YSF3" EXACT []

[Term]
id: sgd:S000028510
name: YBR111W-A
def: "Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "SUS1" EXACT []

[Term]
id: sgd:S000028511
name: YIL156W-B
def: "Putative protein of unknown function; originally identified based on homology to Ashbya gossypii and other related yeasts" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028512
name: YKR095W-A
def: "Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p\, Gon7p\, Bud32p\, and Cgi121p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "PCC1" EXACT []

[Term]
id: sgd:S000028513
name: YJR112W-A
def: "Putative protein of unknown function; identified based on homology to Ashbya gossypii" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028514
name: YMR194C-B
def: "Protein that localizes to the mitochondrial intermembrane space; localizes via the Mia40p-Erv1p system; contains twin cysteine-x\(9\)-cysteine motifs" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "CMC4" EXACT []

[Term]
id: sgd:S000028515
name: YPR170W-B
def: "Putative protein of unknown function; conserved in fungi; partially overlaps the dubious genes YPR169W-A\, YPR170W-A and YRP170C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028516
name: YOR072W-B
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028517
name: YBL039W-B
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YBL039W-A" EXACT []

[Term]
id: sgd:S000028518
name: YCL058W-A
def: "Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "ADF1" EXACT []

[Term]
id: sgd:S000028519
name: YCR075W-A
def: "Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog\, YNR034W-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028520
name: YDL160C-A
def: "Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-X\, also known as MHF2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MHF2" EXACT []

[Term]
id: sgd:S000028521
name: YGR169C-A
def: "Putative protein of unknown function; LSO2 has a paralog\, LSO1\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSO2" EXACT []
synonym: "YGR169C-C" EXACT []

[Term]
id: sgd:S000028522
name: YJL127C-B
def: "Putative protein of unknown function; identified based on homology to the filamentous fungus\, Ashbya gossypii" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YJL127C-A" EXACT []

[Term]
id: sgd:S000028523
name: YJR005C-A
def: "Putative protein of unknown function; transcription increases during treatment with 2-\(6-benzyl-2-pyridyl\)quinazoline \(BPQ\) and copper\, and may be regulated by Aft1p; originally identified as a syntenic homolog of an Ashbya gossypii gene; LSO1 has a paralog\, LSO2\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "LSO1" EXACT []

[Term]
id: sgd:S000028524
name: YKL068W-A
def: "Putative protein of unknown function; identified by homology to Ashbya gossypii" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028525
name: YLR307C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028526
name: YOR020W-A
def: "Putative protein of unknown function; conserved in A. gossypii; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028527
name: YPL189C-A
def: "Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COA2" EXACT []

[Term]
id: sgd:S000028528
name: YAL016C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028529
name: YBL008W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028530
name: YBL068W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028532
name: YBR072C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028533
name: YBR076C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028534
name: YBR196C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028535
name: YBR200W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028536
name: YCR108C
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028537
name: YDL022C-A
def: "Protein of unknown function; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028538
name: YDR169C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028539
name: YDR182W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028540
name: YDR183C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028541
name: YDR194W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028542
name: YDR246W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028543
name: YDR406W-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDR406C-A" EXACT []

[Term]
id: sgd:S000028544
name: YEL020C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028545
name: YEL050W-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028546
name: YER078W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028547
name: YFL041W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028548
name: YGL041C-B
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028550
name: YGR121W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028551
name: YGR240C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028552
name: YHR086W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028553
name: YHR175W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028554
name: YHR180C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028555
name: YHR180W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028556
name: YIL134C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028557
name: YJR151W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational \"guilt by association\" analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028558
name: YKL183C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028560
name: YLL006W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028561
name: YLR154C-G
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028562
name: YLR154C-H
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog\, YLR157C-C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028563
name: YLR154W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028564
name: YLR156C-A
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog\, YLR159C-A\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028565
name: YLR157C-C
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog\, YLR154C-H\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028566
name: YLR159C-A
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog\, YLR156C-A\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028567
name: YLR162W-A
def: "Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RRT15" EXACT []

[Term]
id: sgd:S000028568
name: YLR222C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028569
name: YLR285C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028571
name: YLR342W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028572
name: YLR412C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028573
name: YML054C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028574
name: YMR030W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028575
name: YMR141W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028576
name: YMR230W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028578
name: YMR307C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene GAS1/YMR307W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028579
name: YNL130C-A
def: "Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "DGR1" EXACT []

[Term]
id: sgd:S000028580
name: YOL164W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028581
name: YOR011W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028582
name: YOR072W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028583
name: YOR073W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028584
name: YOR316C-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028585
name: YOR329W-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028586
name: YOR376W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028587
name: YOR381W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028588
name: YPL038W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028589
name: YPL250W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028590
name: YPR108W-A
def: "Putative protein of unknown function; identified by fungal homology and RT-PCR" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028591
name: YPR169W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs\: YPR170C and YPR170W-B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028592
name: YAL037C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028593
name: YAL067W-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028594
name: YAL068W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028595
name: YAR035C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; predicted to have a role in cell budding based on computational \"guilt by association\" analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028596
name: YBL006W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028597
name: YBL071C-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028598
name: YBL100W-C
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YBL101W-C" EXACT []

[Term]
id: sgd:S000028599
name: YBL113W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028600
name: YBR126W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray analysis\, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR126W-B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028601
name: YBR131C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W; identified by gene-trapping\, microarray analysis\, and genome-wide homology searches" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028602
name: YBR141W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping\, microarray analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028603
name: YBR182C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028604
name: YBR223W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028605
name: YBR296C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028606
name: YBR298C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028607
name: YCR045W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028608
name: YCR047W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028609
name: YCR081C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028610
name: YDL025W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028611
name: YDL086C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028612
name: YDL159C-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDL159C-A" EXACT []

[Term]
id: sgd:S000028613
name: YDR354C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028614
name: YDR464C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028615
name: YDR510C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028616
name: YDR524C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDR524C-C" EXACT []

[Term]
id: sgd:S000028617
name: YDR545C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028618
name: YEL008C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028619
name: YEL030C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028620
name: YEL032C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028621
name: YEL077W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028622
name: YER023C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028623
name: YER088W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping\, expression analysis\, and homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028624
name: YER158W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028625
name: YER175W-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028626
name: YER190C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping\, expression analysis\, and homology" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028627
name: YER190C-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028628
name: YFL013W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028629
name: YFL031C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YFL030C-A" EXACT []

[Term]
id: sgd:S000028630
name: YFR032C-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028631
name: YFR034W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping\, microarray expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028632
name: YGL007C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028633
name: YGL063C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028634
name: YGL123C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028635
name: YGL188C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028636
name: YGR031C-A
def: "Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "NAG1" EXACT []

[Term]
id: sgd:S000028637
name: YGR068W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028638
name: YGR146C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028639
name: YGR174W-A
def: "Putative protein of unknown function; predicted to have a role in cell budding based on computational \"guilt by association\" analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028640
name: YGR204C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028641
name: YGR270C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028642
name: YGR296C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps TEL07R" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028643
name: YGR296C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; contained completely within TEL07R" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028644
name: YHL050W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028645
name: YHR022C-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028646
name: YHR032C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028647
name: YHR052W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps CUP1-1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028648
name: YHR054W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps CUP1-2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028649
name: YHR137C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping\, expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028650
name: YHR212W-A
def: "Pseudogenic fragment with similarity to flocculins; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; YHR212W-A has a paralog\, YAR061W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028651
name: YHR213W-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028652
name: YHR213W-B
def: "Pseudogenic fragment with similarity to flocculins; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; YHR213W-B has a paralog\, YAR064W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028653
name: YHR214C-D
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; YHR214C-D has a paralog\, YAR069C\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028654
name: YHR214C-E
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028655
name: YHR219C-A
def: "Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028656
name: YIL021C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping\, expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028657
name: YIL105W-A
def: "Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028658
name: YIL177W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028659
name: YJL020W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028660
name: YJL026C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028661
name: YJL077W-A
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028662
name: YJL077W-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028663
name: YJL222W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028664
name: YJL222W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028665
name: YJL225W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028666
name: YJR140W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene HIR3; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028667
name: YKL096C-B
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028668
name: YKL156C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene RPS27A; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028669
name: YKR075W-A
def: "Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028670
name: YLL019W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene KNS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028671
name: YLL066W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028672
name: YLL066W-B
def: "Putative protein of unknown function; overexpression causes a cell cycle delay or arrest" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028673
name: YLL067W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps YLL067C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028674
name: YLR120W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR121C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028675
name: YLR154W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YLR154W-C" EXACT []

[Term]
id: sgd:S000028676
name: YLR154W-E
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028677
name: YLR157W-D
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching; YLR157W-D has a paralog\, YLR161W\, that arose from a segmental duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YLR157W-A" EXACT []

[Term]
id: sgd:S000028678
name: YLR157W-E
def: "Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis\, and genome-wide homology searching; partially overlaps a Ty1 element" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YLR157W-B" EXACT []
synonym: "YLR157W-C" EXACT []

[Term]
id: sgd:S000028679
name: YLR286W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene CTS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028680
name: YLR299C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene ECM38" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028681
name: YLR347W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028682
name: YLR399W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028683
name: YLR406C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028684
name: YLR437C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028685
name: YLR466C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028686
name: YLR466C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028687
name: YLR467C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028688
name: YML100W-A
def: "Putative protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028689
name: YML133W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028690
name: YML133W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028691
name: YMR001C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028692
name: YMR105W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028693
name: YMR182W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028694
name: YMR242W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028695
name: YMR272W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028696
name: YMR272W-B
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028697
name: YMR315W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028698
name: YNL024C-A
def: "Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "KSH1" EXACT []

[Term]
id: sgd:S000028699
name: YNL097C-B
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YNL097C-A" EXACT []

[Term]
id: sgd:S000028700
name: YNL097W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028701
name: YNL103W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028702
name: YNL144W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028703
name: YNL339W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028704
name: YNL339W-B
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028705
name: YNR003W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028706
name: YNR075C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028707
name: YOL019W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028708
name: YOL085W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028709
name: YOL166W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028710
name: YOR032W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028711
name: YOR108C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028712
name: YOR161C-C
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028713
name: YOR161W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028714
name: YOR161W-B
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028715
name: YOR186C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028716
name: YOR231C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028717
name: YOR335W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028718
name: YOR394C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028719
name: YOR396C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028720
name: YPL135C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028721
name: YPL152W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028722
name: YPL222C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028723
name: YPL283W-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028724
name: YPL283W-B
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028725
name: YPR159C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028726
name: YPR160C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028727
name: YPR204C-A
def: "Protein of unknown function; identified by gene-trapping\, microarray-based expression analysis\, and genome-wide homology searching" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028728
name: YAL016C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF TPD3/YAL016W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028729
name: YAL019W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF ATS1/YAL020C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028730
name: YAL026C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028731
name: YAL031W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF GIP4/YAL031C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028732
name: YAL037C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028733
name: YAL047W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF GEM1/YAL048C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028734
name: YAL059C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028735
name: YAR019W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF CDC15/YAR019C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028736
name: YBR056W-A
def: "Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog\, YDR034W-B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028737
name: YBR109W-A
def: "Putative protein of unknown function; questionable ORF from MIPS" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028738
name: YBR126W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028739
name: YDR524C-B
def: "Putative protein of unknown function; YDR524C-B has a paralog\, YCL048W-A\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028740
name: YDR524W-C
def: "Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YDR524W-A" EXACT []

[Term]
id: sgd:S000028741
name: YEL009C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF YEL010W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028742
name: YEL018C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF EAF5/YEL018W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028743
name: YEL034C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps HYP2/YEL034W\, a verified gene that encodes eiF-5A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028744
name: YEL053W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified gene RPL12A/YEL054C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028745
name: YER006C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2/YER007W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028746
name: YER038W-A
def: "Mitochondrial protein of unknown function; almost completely overlaps ORF HVG1/YER039C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028747
name: YER046W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028748
name: YER067C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF RGI1/YER067W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028749
name: YER068C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF ARG5\,6/YER069W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028750
name: YER076W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028751
name: YER079C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF AIM9/YER080W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028752
name: YER084W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps uncharacterized ORF YER085C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028753
name: YER087C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF AIM10/YER087W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028754
name: YER088C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORFs PTC2/YER089C and YER088W-B" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028755
name: YER107W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF GLE2/YER107C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028756
name: YER133W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF YER134C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028757
name: YER137W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF YER137C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028758
name: YER145C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps verified ORF LSM5/YER146W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028759
name: YER147C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF SPT15/YER148W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028760
name: YER148W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF PEA2/YER149C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028761
name: YER152W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF YER152C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028762
name: YER165C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028763
name: YER172C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF RAD24/YER173W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028764
name: YER188C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028765
name: YFL015W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF YFL015C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028766
name: YFL021C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF GAT1/YFL021W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028767
name: YFR036W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps verified ORF RSC8/YFR037C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028768
name: YFR052C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF HXK1/YFR053C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028769
name: YGL006W-A
def: "Putative protein of unknown function; identified by SAGE" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028770
name: YHL002C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF HSE1/YHL002W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028771
name: YHL006W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF STE20/YHL007C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028772
name: YHL019W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028773
name: YHL030W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028774
name: YHL034W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028775
name: YHL046W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028776
name: YHR028W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028777
name: YHR056W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028778
name: YHR063W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028779
name: YHR069C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028780
name: YHR070C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028781
name: YHR071C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028782
name: YHR131W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YHR131C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028783
name: YHR165W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps ORF PRP8/YHR165C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028784
name: YHR182C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF GND1/YHR183W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028785
name: YHR193C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028786
name: YHR218W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely within telomere TEL08L" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028787
name: YIL020C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918\, partially overlaps ORF RPB3/YIL021W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028788
name: YIL029W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF SSM4/YIL030C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028789
name: YIL030W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps ORF ULP2/YIL031W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028790
name: YIL047C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF SYG1/YIL047C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028791
name: YIL066W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF YIL067C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028792
name: YIL068W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF SEC6/YIL068C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028793
name: YIL071W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF PCI8/YIL071C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028794
name: YIL100C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028795
name: YIL115W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028796
name: YIL142C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF CCT2/YIL142W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028797
name: YIL156W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF COA1/YIL157C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028798
name: YIL171W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF IMA3/YIL172C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028799
name: YIR017W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028800
name: YIR020C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028801
name: YIR023C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps ORF DAL81/YIR023W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028802
name: YIR030W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF DAL7/YIR031C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028803
name: YIR036W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps ORF IRC24/YIR036C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028804
name: YJL047C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028805
name: YJL133C-A
def: "Putative protein of unknown function; the authentic\, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028806
name: YJL136W-A
def: "Putative protein of unknown function; identified by SAGE" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028808
name: YLR264C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028809
name: YML031C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF NDC1/YML031W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YML032C-A" EXACT []

[Term]
id: sgd:S000028810
name: YNL067W-B
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YNL067W-A" EXACT []

[Term]
id: sgd:S000028811
name: YOL013W-A
def: "Putative protein of unknown function; identified by SAGE" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YOL013W-B" EXACT []

[Term]
id: sgd:S000028812
name: YOL038C-A
def: "Putative protein of unknown function; identified by SAGE analysis" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028813
name: YAL063C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028814
name: YBL039C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028815
name: YBR121C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely contained within the verified gene GRS1; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028816
name: YBR196C-B
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028817
name: YBR221W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028818
name: YCR024C-B
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028819
name: YDR003W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028820
name: YDR118W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified using a combination of expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028821
name: YDR320W-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028822
name: YDR371C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028823
name: YFR009W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028824
name: YFR010W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028825
name: YGL014C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028826
name: YGL041W-A
def: "Putative protein of unknown function; conserved in fungi; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028827
name: YGR035W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028828
name: YHL015W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028829
name: YHL048C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028830
name: YHR007C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028831
name: YHR032W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028832
name: YHR050W-A
def: "Protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028833
name: YHR073C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028834
name: YHR073W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028835
name: YIL002W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028836
name: YIL046W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028837
name: YIR018C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028838
name: YIR021W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028839
name: YJL197C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028840
name: YKL100W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028841
name: YKL145W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028843
name: YLR154W-F
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028844
name: YLR163W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028845
name: YLR361C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028846
name: YLR364C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028847
name: YMR013C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028848
name: YMR175W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028849
name: YMR247W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028850
name: YNL042W-B
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028851
name: YNL146C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028852
name: YNL277W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028853
name: YOL083C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028854
name: YOL097W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028855
name: YOL155W-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028856
name: YOR034C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028857
name: YOR192C-C
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028858
name: YOR293C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028859
name: YPL119C-A
def: "Putative protein of unknown function; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028860
name: YPR160W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000028861
name: YPR170W-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000029704
name: YHR199C-A
def: "Subunit of the conserved chromosomal passenger complex \(CPC\); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p\, Sli15p\, and Bir1p" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "MCL1" EXACT []
synonym: "NBL1" EXACT []

[Term]
id: sgd:S000029705
name: YCL012C
def: "Putative protein of unknown function; orthologs are present in S. bayanus\, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "YCL011C-A" EXACT []

[Term]
id: sgd:S000029722
name: YBR230W-A
def: "Putative protein of unknown function; YBR230W-A has a paralog\, COQ8\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000029724
name: YCR095W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000029725
name: YER090C-A
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000029726
name: YGR161W-C
def: "Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000087085
name: YBR201C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000087087
name: YBR056C-B
def: "Dubious open reading frame; unlikely to encode a functional protein\, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000087160
name: YGL194C-A
def: "Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000087203
name: YCL048W-A
def: "Putative protein of unknown function; YCL048W-A has a paralog\, YDR524C-B\, that arose from the whole genome duplication" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000087209
name: YDR461C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113553
name: YDR374W-A
def: "Kinetochore localized protein of unknown function; interacts with Cnn1p \(CENP-T\); orthologous to human centromere constitutive-associated network \(CCAN\) subunit CENP-W and fission yeast new1" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "WIP1" EXACT []

[Term]
id: sgd:S000113555
name: YDR119W-A
def: "Putative protein of unknown function; copurifies with respiratory chain supercomplexes composed of Complex III \(ubiquinol-cytochrome c reductase\) and Complex IV \(cytochrome c oxidase\)" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "COX26" EXACT []

[Term]
id: sgd:S000113557
name: YDL007C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113559
name: YKL023C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113563
name: YKL065W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113566
name: YLR146W-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113587
name: YIL102C-A
def: "Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113589
name: YPR145C-A
def: "Putative protein of unknown function" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000113613
name: YDR014W-A
def: "Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene\, transcribed specifically during meiotic prophase" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "HED1" EXACT []

[Term]
id: sgd:S000122558
name: YPR010C-A
def: "Putative protein of unknown function; conserved among Saccharomyces sensu stricto species" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae

[Term]
id: sgd:S000178054
name: YCL054W-A
def: "Short open reading frame\, shows evidence of translation; may be new protein-coding gene that originated de novo from noncoding sequence; same allele found in at least 33 other S. cerevisiae strains; at least 3 strains have a second allele with three nucleotide substitutions leading to two amino acid differences" []
relationship: RO:0002162 NCBITaxon:4932 ! in taxon Saccharomyces cerevisiae
synonym: "RDT1" EXACT []