@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix gufo: <http://purl.org/nemo/gufo#> .
@prefix hrio: <https://w3id.org/health-ri/ontology#> .
@prefix mod: <https://w3id.org/mod#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix vann: <http://purl.org/vocab/vann/> .
@prefix vs: <http://www.w3.org/2003/06/sw-vocab-status/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://w3id.org/health-ri/ontology> a owl:Ontology ;
    dct:abstract "Developed by Health‑RI and collaborators, this ontology—grounded in UFO and implemented in gUFO/OWL—enables semantic interoperability across healthcare and life sciences, extending beyond systems to include institutions, research infrastructures, and services. It establishes a common reference model that harmonizes data from diverse sources by formally defining domain concepts and allowing mappings from heterogeneous sources."@en ;
    dct:conformsTo <https://w3id.org/health-ri/ontology/v2.1.0/json>,
        <https://w3id.org/health-ri/ontology/v2.1.0/vpp> ;
    dct:contributor <https://orcid.org/0000-0001-8802-7002>,
        <https://orcid.org/0000-0002-7944-2594>,
        <https://orcid.org/0000-0003-0771-3516>,
        <https://orcid.org/0000-0003-1451-4240>,
        <https://orcid.org/0000-0003-4715-9070>,
        <https://orcid.org/0009-0000-0967-7294>,
        <https://orcid.org/0009-0002-3089-9558>,
        <https://orcid.org/0009-0006-1783-9082> ;
    dct:creator <https://orcid.org/0000-0003-2736-7817> ;
    dct:description "This ontology is part of Health-RI’s semantic interoperability initiative, which provides a shared ontological framework for harmonizing healthcare and life sciences data across institutions. It includes a conceptual reference model defined in OntoUML and a machine-processable OWL ontology implemented using gUFO. These artifacts are used to enable explicit mappings from heterogeneous data schemas, ensuring consistent semantics in data exchange and integration. The approach supports both human understanding and computational tractability. All components are openly published and designed for reuse across systems and services."@en ;
    dct:identifier "https://w3id.org/health-ri/ontology" ;
    dct:issued "2025-05-20"^^xsd:date ;
    dct:language "en"^^xsd:language ;
    dct:license <https://creativecommons.org/licenses/by/4.0/> ;
    dct:modified "2026-03-11"^^xsd:date ;
    dct:publisher <https://w3id.org/health-ri> ;
    dct:title "Health-RI Ontology"@en ;
    vann:preferredNamespacePrefix "hrio" ;
    vann:preferredNamespaceUri "https://w3id.org/health-ri/ontology#"^^xsd:anyURI ;
    owl:imports gufo: ;
    owl:versionIRI <https://w3id.org/health-ri/ontology/v2.1.0> ;
    owl:versionInfo "2.1.0" ;
    dcat:hasVersion <https://w3id.org/health-ri/ontology/v0.10.1>,
        <https://w3id.org/health-ri/ontology/v0.11.9>,
        <https://w3id.org/health-ri/ontology/v0.4.0>,
        <https://w3id.org/health-ri/ontology/v0.5.2>,
        <https://w3id.org/health-ri/ontology/v0.6.0>,
        <https://w3id.org/health-ri/ontology/v0.9.2>,
        <https://w3id.org/health-ri/ontology/v1.1.1>,
        <https://w3id.org/health-ri/ontology/v1.2.1>,
        <https://w3id.org/health-ri/ontology/v1.3.0>,
        <https://w3id.org/health-ri/ontology/v1.4.0>,
        <https://w3id.org/health-ri/ontology/v1.5.0>,
        <https://w3id.org/health-ri/ontology/v1.6.2>,
        <https://w3id.org/health-ri/ontology/v2.0.0> ;
    dcat:keyword "biomedicine"@en,
        "clinical data"@en,
        "health information systems"@en,
        "healthcare"@en,
        "life sciences"@en,
        "medical terminology"@en ;
    dcat:landingPage <https://w3id.org/health-ri/semantic-interoperability> ;
    foaf:homepage <https://w3id.org/health-ri/semantic-interoperability> ;
    foaf:logo <https://raw.githubusercontent.com/Health-RI/semantic-interoperability/refs/heads/main/docs/assets/images/health-ri-logo-blue.png> ;
    mod:repository <https://w3id.org/health-ri/semantic-interoperability/git> .

<https://w3id.org/health-ri/ontology/v2.1.0> owl:priorVersion <https://w3id.org/health-ri/ontology/v2.0.0> .

hrio:CisgenderPerson_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person .

hrio:DiagnosticMethodType a owl:NamedIndividual ;
    rdfs:label "Diagnostic Method Type"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    gufo:categorizes hrio:DiagnosticMethod ;
    rdfs:comment "A type that classifies diagnostic methods according to the kind of procedure they instantiate. It provides the categorial basis by which individual diagnostic methods are instantiated and compared."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Diagnostic Method Type"@en .

hrio:Disease a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Disease"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Disease is represented as a specialization of Pathological Health Condition. In the model it captures a subset of pathological conditions that are formally identified as diseases, ensuring that such cases are explicitly represented within the broader pathological category."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition,
        hrio:NonTraumaticHealthCondition,
        hrio:PathologicalHealthCondition ;
    skos:prefLabel "Disease"@en .

hrio:ExternalDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "External Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "External Diagnosis is a Diagnosis established by a diagnosing agent who is not identical to the diagnosed entity. It is contrasted with Self-diagnosis, where a single individual plays both Diagnosing Agent and Diagnosed Entity roles; the distinction is based on agent-role separation, independent of method, source, or intended use."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Diagnosis ;
    skos:prefLabel "External Diagnosis"@en .

hrio:Gamete a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gamete"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Gamete is represented as a specific subkind of Haploid Cell. In the model it inherits the single chromosome set characteristic of haploid cells and is positioned as the mature form used in reproductive processes. The diagram shows it as a specialization, clarifying its placement in the ontology as the reproductive entity derived from haploid cellular structures."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HaploidCell ;
    skos:prefLabel "Gamete"@en .

hrio:GenderContext a owl:NamedIndividual ;
    rdfs:label "Gender Context"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender> ;
    gufo:categorizes hrio:Gender ;
    rdfs:comment """Gender Context captures the context in which a gender outcome is established, recorded, or attributed.

It supports distinguishing contexts such as self-identified gender, externally-attributed gender, administrative gender, legal gender, and gender expression, while keeping the context separate from the resulting gender outcome category."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Gender Context"@en .

hrio:GenderModalityType a owl:NamedIndividual ;
    rdfs:label "Gender Modality Type"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    gufo:categorizes hrio:GenderModality ;
    rdfs:comment """Gender Modality Type provides a classifier for gender modality characterizations.

It supports identifying which modality category a given gender modality instance represents, such as cisgender or transgender, to enable consistent use and interpretation across contexts."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Gender Modality Type"@en .

hrio:GenderOutcome a owl:NamedIndividual ;
    rdfs:label "Gender Outcome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender> ;
    gufo:categorizes hrio:Gender ;
    rdfs:comment """Gender Outcome captures the outcome category of a gender characterization.

It supports outcome groupings such as female gender, male gender, and non-binary gender, as well as outcome categories tied to gender expression, while keeping the outcome distinct from the context in which it is established."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Gender Outcome"@en .

hrio:HealthConditionType a owl:NamedIndividual ;
    rdfs:label "Health Condition Type"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    gufo:categorizes hrio:HealthCondition ;
    rdfs:comment "A Health Condition Type is modeled as a type instantiated by individual health conditions. It captures the general categories under which health conditions can be classified, supporting a systematic way of grouping and distinguishing conditions across different contexts. This class ensures that health conditions are not only individual occurrences but are also connected to a broader typology."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Health Condition Type"@en .

hrio:PersonsDeathCauseType a owl:NamedIndividual ;
    rdfs:label "Person's Death Cause Type"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    gufo:categorizes hrio:PersonsDeathCause ;
    rdfs:comment "Person's Death Cause Type classifies kinds of death causes. Each instance serves as the type that a Person's Death Cause instantiates, allowing multiple concrete death causes to share the same type."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Person's Death Cause Type"@en .

hrio:SelfDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosis made by an individual about themself, where the same individual plays the Diagnosing Agent and the Diagnosed Entity roles. It contrasts with External Diagnosis, which presupposes different individuals in those roles."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Diagnosis ;
    skos:prefLabel "Self-diagnosis"@en .

hrio:SelfIdentifiedAgenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Agender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """A Self-identified Agender Person is a self-identified non-binary-gender person whose self-classification is not characterized by any self-identified gender.

This description clarifies that the defining feature of the class is the absence of self-identified gender. It supports a precise understanding of agender self-classification as a distinct form of non-binary self-classification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SelfIdentifiedNonBinaryGenderPerson ;
    skos:prefLabel "Self-identified Agender Person"@en .

hrio:SelfIdentifiedTwoGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Two-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """A Self-identified Two-gender Person is a person whose self-identification is characterized by one self-identified male gender and one self-identified female gender, rather than by a self-identified non-binary gender.

This description clarifies that the class concerns a specific form of non-binary self-classification grounded in the joint presence of male and female self-identification. It helps distinguish this case from other non-binary self-classifications that are not characterized in this way."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SelfIdentifiedMaleGender ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:onClass hrio:SelfIdentifiedFemaleGender ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:SelfIdentifiedNonBinaryGenderPerson ;
    skos:altLabel "Self-identified Two Spirit Person"@en ;
    skos:prefLabel "Self-identified Two-gender Person"@en .

hrio:SexAxis a owl:NamedIndividual ;
    rdfs:label "Sex Axis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    gufo:categorizes hrio:Sex ;
    rdfs:comment """Sex Axis identifies the basis on which a sex characterization is established.

It supports distinguishing sex characterizations grounded in different bases, such as phenotypic sex, karyotypic sex, and sex at birth, while keeping that basis separate from the resulting sex outcome category."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Sex Axis"@en .

hrio:SexGenderOutcome a owl:NamedIndividual ;
    rdfs:label "Sex-Gender Outcome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender> ;
    gufo:categorizes hrio:SexGender ;
    rdfs:comment "Sex-Gender Outcome is a powertype whose instances correspond to the Sex-Gender outcome types (e.g., Female, Male, Non-binary Sex-Gender) used to classify Sex-Gender. It enables treating these outcomes as types in the model and supports consistent classification of Sex-Gender instances."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Sex-Gender Outcome"@en .

hrio:SexGenderType a owl:NamedIndividual ;
    rdfs:label "Sex-Gender Type"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender> ;
    gufo:categorizes hrio:SexGender ;
    rdfs:comment """Sex-Gender Type provides a classifier for sex-gender characterizations of persons.

It supports distinguishing which kind of sex-gender characterization is being applied, including characterizations treated as sex, treated as gender, or treated as a dedicated sex-gender outcome category."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Sex-Gender Type"@en .

hrio:SexOutcome a owl:NamedIndividual ;
    rdfs:label "Sex Outcome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    gufo:categorizes hrio:Sex ;
    rdfs:comment """Sex Outcome captures the outcome category of a sex characterization.

It supports outcome groupings such as female sex, male sex, and indeterminate sex, and it enables using these outcome categories to characterize persons without conflating them with the basis on which sex was established."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ConcreteIndividualType ;
    skos:prefLabel "Sex Outcome"@en .

hrio:TransgenderPerson_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person .

hrio:animalInheresInHealthCondition rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:conditionInheresInSubstantial .

hrio:birthCityOrLocation a owl:DatatypeProperty ;
    rdfs:label "birth city or location"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "birth city or location"@en .

hrio:birthCountry a owl:DatatypeProperty ;
    rdfs:label "birth country"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "birth country"@en .

hrio:birthDate a owl:ObjectProperty ;
    rdfs:label "birth date"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Date ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "birth date"@en .

hrio:birthDateTime a owl:ObjectProperty ;
    rdfs:label "birth date-time"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:OffsetDateTime ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "birth date-time"@en .

hrio:birthPlaceAddress a owl:ObjectProperty ;
    rdfs:label "birth place address"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Address ;
    skos:prefLabel "birth place address"@en .

hrio:birthPosition a owl:DatatypeProperty ;
    rdfs:label "birth position"@en ;
    rdfs:domain hrio:MultipleBirthComponent ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "birth position"@en .

hrio:birthYear a owl:DatatypeProperty ;
    rdfs:label "birth year"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "birth year"@en .

hrio:buildingName a owl:DatatypeProperty ;
    rdfs:label "building name"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "building name"@en .

hrio:careOf a owl:DatatypeProperty ;
    rdfs:label "care of"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "care of"@en .

hrio:cityOrLocation a owl:DatatypeProperty ;
    rdfs:label "city or location"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "city or location"@en .

hrio:country a owl:DatatypeProperty ;
    rdfs:label "country"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "country"@en .

hrio:countryCode a owl:DatatypeProperty ;
    rdfs:label "country code"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "country code"@en .

hrio:createsOnBehalfOf a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "creates on behalf of"@en ;
    rdfs:domain hrio:AdministrativeGenderRecognitionAgent ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:AdministrativeGenderRecognizingOrganization ;
    skos:prefLabel "creates on behalf of"@en .

hrio:currentAge a owl:DatatypeProperty ;
    rdfs:label "current age"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "current age"@en .

hrio:date a owl:ObjectProperty ;
    rdfs:label "date"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Date ;
    skos:prefLabel "date"@en .

hrio:day a owl:DatatypeProperty ;
    rdfs:label "day"@en ;
    rdfs:domain hrio:Date ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "day"@en .

hrio:districtOrNeighborhood a owl:DatatypeProperty ;
    rdfs:label "district or neighborhood"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "district or neighborhood"@en .

hrio:end a owl:ObjectProperty ;
    rdfs:label "end"@en ;
    rdfs:domain hrio:MultipleBirth ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:OffsetDateTime ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "end"@en .

hrio:end_1 a owl:ObjectProperty ;
    rdfs:label "end"@en ;
    rdfs:domain hrio:SingleBirth ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:OffsetDateTime ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "end"@en .

hrio:femaleTypicalDimorphicCharacteristicIsComponentOfFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexualDimorphicCharacteristicIsComponentOfPerson .

hrio:femaleTypicalVisualSexCharacteristicIsComponentOfPhenotypicFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:personIsComponentOfVisualSexCharacteristic .

hrio:femininePresentingPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:femaleGenderInheresInFemaleGenderPerson .

hrio:floor a owl:DatatypeProperty ;
    rdfs:label "floor"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "floor"@en .

hrio:hasAllosome a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "has allosome"@en ;
    rdfs:domain hrio:Person ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Allosome ;
    skos:prefLabel "has allosome"@en .

hrio:hasCause a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "has cause"@en ;
    rdfs:domain hrio:GenderModality ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Sex ;
    skos:prefLabel "has cause"@en .

hrio:hasCause_1 a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "has cause"@en ;
    rdfs:domain hrio:GenderModality ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Gender ;
    skos:prefLabel "has cause"@en .

hrio:hour a owl:DatatypeProperty ;
    rdfs:label "hour"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "hour"@en .

hrio:houseNumber a owl:DatatypeProperty ;
    rdfs:label "house number"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "house number"@en .

hrio:houseNumberExtension a owl:DatatypeProperty ;
    rdfs:label "house number extension"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "house number extension"@en .

hrio:indeterminateDimorphicCharacteristicIsComponentOfIndeterminateSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexualDimorphicCharacteristicIsComponentOfPerson .

hrio:indeterminateVisualSexCharacteristicIsComponentOfPhenotypicAmbiguousSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:personIsComponentOfVisualSexCharacteristic .

hrio:isBornIn_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:isBornIn .

hrio:isGeneticFatherOf a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "is genetic father of"@en ;
    rdfs:domain hrio:GeneticFather ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Person ;
    skos:prefLabel "is genetic father of"@en .

hrio:isGeneticMotherOf a gufo:MaterialRelationshipType,
        owl:ObjectProperty ;
    rdfs:label "is genetic mother of"@en ;
    rdfs:domain hrio:GeneticMother ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Person ;
    skos:prefLabel "is genetic mother of"@en .

hrio:karyotypicFemaleSexInheresInKaryotypicFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:femaleSexInheresInFemaleSexPerson,
        hrio:personInheresInKaryotypicSex .

hrio:karyotypicMaleSexInheresInKaryotypicMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:maleSexInheresInMaleSexPerson,
        hrio:personInheresInKaryotypicSex .

hrio:legalFemaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:administrativeFemaleGenderPerson .

hrio:legalMaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:administrativeMaleGenderPerson .

hrio:legalNonBinaryGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:administrativeNonBinaryGenderPerson .

hrio:legallyRecognizedGenderPersonInheresInLegalGender rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:administrativeGenderInheresInAdministrativelyRecognizedGenderPerson .

hrio:maleTypicalDimorphicCharacteristicIsComponentOfMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexualDimorphicCharacteristicIsComponentOfPerson .

hrio:maleTypicalVisualSexCharacteristicIsComponentOfPhenotypicMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:personIsComponentOfVisualSexCharacteristic .

hrio:masculinePresentingPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:maleGenderInheresInMaleGenderPerson .

hrio:minute a owl:DatatypeProperty ;
    rdfs:label "minute"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "minute"@en .

hrio:month a owl:ObjectProperty ;
    rdfs:label "month"@en ;
    rdfs:domain hrio:Date ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:Month ;
    skos:prefLabel "month"@en .

hrio:nanosecond a owl:DatatypeProperty ;
    rdfs:label "nanosecond"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "nanosecond"@en .

hrio:nonBinaryPresentingPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:nonBinaryGenderInheresInNonBinaryGenderPerson .

hrio:postOfficeBox a owl:DatatypeProperty ;
    rdfs:label "post office box"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "post office box"@en .

hrio:postalCode a owl:DatatypeProperty ;
    rdfs:label "postal code"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "postal code"@en .

hrio:recognitionBy rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:recognizedBy .

hrio:recognizes rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:recognizes_1 .

hrio:recognizesGender_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:recognizesGender .

hrio:regionOrState a owl:DatatypeProperty ;
    rdfs:label "region or state"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "region or state"@en .

hrio:second a owl:DatatypeProperty ;
    rdfs:label "second"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "second"@en .

hrio:selfAwarePerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_1 .

hrio:selfIdentifiedFemaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:femaleGenderInheresInFemaleGenderPerson,
        hrio:selfIdentifiedGenderInheresInSelfAwarePerson .

hrio:selfIdentifiedMaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:maleGenderInheresInMaleGenderPerson,
        hrio:selfIdentifiedGenderInheresInSelfAwarePerson .

hrio:selfIdentifiedNonBinaryGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:nonBinaryGenderInheresInNonBinaryGenderPerson,
        hrio:selfIdentifiedGenderInheresInSelfAwarePerson .

hrio:selfIdentifiedTwoGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:selfIdentifiedGenderInheresInSelfAwarePerson .

hrio:selfIdentifiedTwoGenderPerson_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:selfIdentifiedGenderInheresInSelfAwarePerson .

hrio:sexAtBirthFemaleSexInheresInSexAtBirthFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:phenotypicFemaleSexInheresInPhenotypicFemaleSexPerson,
        hrio:sexAtBirthInheresInSexAtBirthAssignedPerson .

hrio:sexAtBirthIndeterminateSexInheresInSexAtBirthIndeterminateSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:phenotypicAmbiguousSexInheresInPhenotypicAmbiguousSexPerson,
        hrio:sexAtBirthInheresInSexAtBirthAssignedPerson .

hrio:sexAtBirthMaleSexInheresInSexAtBirthMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:phenotypicMaleSexInheresInPhenotypicMaleSexPerson,
        hrio:sexAtBirthInheresInSexAtBirthAssignedPerson .

hrio:start a owl:ObjectProperty ;
    rdfs:label "start"@en ;
    rdfs:domain hrio:MultipleBirth ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:OffsetDateTime ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "start"@en .

hrio:start_1 a owl:ObjectProperty ;
    rdfs:label "start"@en ;
    rdfs:domain hrio:SingleBirth ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range hrio:OffsetDateTime ;
    rdfs:subPropertyOf gufo:hasReifiedQualityValue ;
    skos:prefLabel "start"@en .

hrio:streetName a owl:DatatypeProperty ;
    rdfs:label "street name"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "street name"@en .

hrio:unitDesignator a owl:DatatypeProperty ;
    rdfs:label "unit designator"@en ;
    rdfs:domain hrio:Address ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "unit designator"@en .

hrio:utcOffsetMinutes a owl:DatatypeProperty ;
    rdfs:label "utcOffsetMinutes"@en ;
    rdfs:domain hrio:OffsetDateTime ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "utcOffsetMinutes"@en .

hrio:value a owl:DatatypeProperty ;
    rdfs:label "value"@en ;
    rdfs:domain hrio:PreferredPronoun ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:string ;
    rdfs:subPropertyOf gufo:hasQualityValue ;
    skos:prefLabel "value"@en .

hrio:year a owl:DatatypeProperty ;
    rdfs:label "year"@en ;
    rdfs:domain hrio:Date ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:range xsd:int ;
    rdfs:subPropertyOf gufo:hasValueComponent ;
    skos:prefLabel "year"@en .

hrio:Adolescent a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Adolescent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Adolescent denotes the life stage of a living person between childhood and adulthood. It is one of the mutually exclusive life-stage categories Child, Adolescent, and Adult shown as a complete set. In the progression constraints indicated, no person can be an adolescent without first being a child."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:LivingPerson ;
    skos:prefLabel "Adolescent"@en .

hrio:Adult a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Adult"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Adult denotes the life stage of a living person after adolescence. It is one of the mutually exclusive life-stage categories Child, Adolescent, and Adult shown as a complete set. In the progression constraints indicated, no person can be an adult without first being an adolescent."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:LivingPerson ;
    skos:prefLabel "Adult"@en .

hrio:April a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:August a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:BirthNotification a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Birth Notification"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment """Represents the official document or record that includes the assigned sex at birth along with other birth details. Often required by legal or administrative systems as the initial source of personal data for registration.

Also called a "birth record" or "attending physician's report"."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirthAssignment ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        gufo:FunctionalComplex ;
    skos:prefLabel "Birth Notification"@en .

hrio:BirthPlace a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Birth Place"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Birth Place is a historical role played by an Addressable Place when it is the location of a Birth event. It classifies a place according to its participation as the site where a Birth occurs.

In this model, each Birth is characterized by exactly one Birth Place, while an Addressable Place may play the Birth Place role for one or more Births (potentially across different times)."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Birth ],
        hrio:AddressablePlace ;
    skos:altLabel "Birth Location"@en,
        "Birthplace"@en,
        "Place of Birth"@en ;
    skos:prefLabel "Birth Place"@en .

hrio:BirthRelatedLegislationRule a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Birth-related Legislation Rule"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Describes the set of legal or regulatory requirements that govern how sex at birth must be assessed, assigned, and recorded. This concept ensures that the model accounts for variation in laws and administrative practices across jurisdictions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    skos:prefLabel "Birth-related Legislation Rule"@en .

hrio:CareOrientedDiagnosis a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Care-oriented Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A healthcare diagnosis whose use is oriented to direct care. Its purpose is to inform decisions for an identified patient or group in a care context, as opposed to surveillance or research uses."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Care-oriented Diagnosis"@en .

hrio:Child a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Child"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Child denotes the life stage of a living person prior to adolescence. It identifies persons who are not yet adolescents or adults and may bear roles that depend on being a child."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:LivingPerson ;
    skos:prefLabel "Child"@en .

hrio:Chromosome a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Chromosome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment """Chromosome is a kind that denotes the thread-like structures composed of nucleic acids and proteins that carry genetic information within human cells. They are the structural units in which genes are organized and transmitted across cell divisions, ensuring the preservation of hereditary information.

In human diploid cells, chromosomes occur in pairs and collectively encode the instructions necessary for development, biological functioning, and reproduction. Chromosomes are further distinguished into categories such as allosomes, which determine chromosomal sex, and autosomes, which are not directly involved in sex determination."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    skos:prefLabel "Chromosome"@en .

hrio:ConcludedDiagnosticRelation a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Concluded Diagnostic Relation"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A temporally subsequent state of a Diagnostic Relation after the diagnostic process has been completed. It is a historical role taken by the relation once it has been determined through Diagnostic Assessment events, and is therefore manifested by such assessments."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty gufo:manifestedIn ;
            owl:someValuesFrom hrio:DiagnosticAssessment ],
        hrio:DiagnosticRelation ;
    skos:prefLabel "Concluded Diagnostic Relation"@en .

hrio:Condition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Condition is a category used to represent a state that inheres in an individual animal as its bearer. In the model, Health Condition specializes Condition, and Condition can be characterized by Condition Indicators that describe or evidence the state in diagnostic contexts."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Substantial ;
            owl:onProperty gufo:inheresIn ],
        [ a owl:Class ;
            owl:unionOf ( gufo:IntrinsicMode gufo:ExtrinsicMode ) ],
        gufo:Aspect ;
    skos:prefLabel "Condition"@en .

hrio:ConditionIndicator a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Condition Indicator"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "An information-bearing item that serves as an indicator about a Condition and characterizes a diagnosed entity. It captures observable or reported features used as evidence during diagnosis, without committing to any particular diagnostic result."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Class ;
            owl:unionOf ( gufo:IntrinsicMode gufo:ExtrinsicMode ) ],
        gufo:Aspect ;
    skos:prefLabel "Condition Indicator"@en .

hrio:DeadCellularEntity a gufo:PhaseMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Dead Cellular Entity"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Dead Cellular Entity is represented as a phase of a cellular entity in which biological activity is no longer present. In the model it complements the living state as part of a complete and disjoint partition, ensuring that both conditions of cellular existence are accounted for. This class makes explicit that cellular entities remain identifiable even after death within the ontology."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CellularEntity ;
    skos:prefLabel "Dead Cellular Entity"@en .

hrio:December a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:DiagnosedBiologicalPart a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosed Biological Part"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosed entity that is a biological part of an organism. The role applies when the diagnostic focus is a component such as an organ, tissue, or other anatomical part rather than the whole organism."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:DiagnosedEntity ;
    skos:prefLabel "Diagnosed Biological Part"@en .

hrio:DiagnosedCellularEntity a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosed Cellular Entity"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosed entity that is a cellular entity. The role applies when the diagnostic focus is at cell level or below, covering cells and their subcellular structures."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CellularEntity,
        hrio:DiagnosedEntity ;
    skos:prefLabel "Diagnosed Cellular Entity"@en .

hrio:DiagnosedGroup a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosed Group"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosed entity that is a group considered as the diagnostic focus. The role applies when the assessment concerns a set of individuals as a group rather than each member separately."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:DiagnosedEntity ;
    skos:prefLabel "Diagnosed Group"@en .

hrio:DiagnosedSpecimen a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosed Specimen"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosed entity that is a specimen used for diagnostic purposes. The role applies to collected biological material that serves as the focus of assessment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:DiagnosedEntity ;
    skos:prefLabel "Diagnosed Specimen"@en .

hrio:DiagnosingArtificialAgent a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosing Artificial Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "An artificial agent that bears the diagnosing role in a diagnostic process. It participates as a diagnosing agent when a system or device performs diagnostic activities within a Diagnostic Relation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ArtificialAgent,
        hrio:DiagnosingAgent ;
    skos:prefLabel "Diagnosing Artificial Agent"@en .

hrio:DiagnosisSuspicion a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosis Suspicion"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A belief held by a diagnosing agent that characterizes that agent regarding the possibility of a Condition in a diagnosed entity. It reflects a preliminary cognitive stance prior to or during assessment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:DiagnosingAgent ;
            owl:onProperty gufo:inheresIn ],
        hrio:Belief ;
    skos:prefLabel "Diagnosis Suspicion"@en .

hrio:DiagnosticOutcomeIssuer a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnostic Outcome Issuer"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "An agent that bears the role of issuing a diagnostic assessment outcome. It is responsible for producing or communicating the outcome that characterizes the result of a diagnostic assessment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:DiagnosticAssessmentOutcome ],
        hrio:DiagnosingAgent ;
    skos:prefLabel "Diagnostic Outcome Issuer"@en .

hrio:DiploidCell a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diploid Cell"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Diploid Cell is a human cell characterized by the presence of two chromosome sets. It is modeled as a subkind of Human Cell that includes chromosomes as components, with the number of chromosomes distinguishing it from other cell types in the model. In this representation, the diploid structure is complete and disjoint relative to the haploid alternative, reflecting its role in forming the ordinary chromosomal basis of human somatic cells."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HumanCell ;
    skos:prefLabel "Diploid Cell"@en .

hrio:Endurant a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Endurant"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/UFO> ;
    rdfs:comment "Endurant is an individual that is wholly present whenever it exists and can persist through time while undergoing change. It provides the upper-level basis from which more specific substantial categories are specialized."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Particular ;
    skos:prefLabel "Endurant"@en .

hrio:ExternallyAttributedCisgenderFemalePerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Cisgender Female Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """An Externally-attributed Cisgender Female Person is a person for whom another individual attributes a cisgender status together with a female gender attribution.

This class applies when the attributed female gender is consistent with the person's female sex at birth, and the cisgender status is grounded in that external attribution rather than in the person's self-identification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyAttributedCisgenderPerson,
        hrio:ExternallyAttributedFemaleGenderPerson,
        hrio:SexAtBirthFemaleSexPerson ;
    skos:prefLabel "Externally-attributed Cisgender Female Person"@en .

hrio:ExternallyAttributedCisgenderMalePerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Cisgender Male Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """An Externally-attributed Cisgender Male Person is a person for whom another individual attributes a cisgender status together with a male gender attribution.

This class applies when the attributed male gender is consistent with the person's male sex at birth, and the cisgender status is grounded in that external attribution rather than in the person's self-identification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyAttributedCisgenderPerson,
        hrio:ExternallyAttributedMaleGenderPerson,
        hrio:SexAtBirthMaleSexPerson ;
    skos:prefLabel "Externally-attributed Cisgender Male Person"@en .

hrio:February a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:FemaleCisgenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female Cisgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """Female Cisgender Person is a cisgender person whose recorded sex at birth is female and whose gender classification is female. It captures a form of cisgender modality grounded in alignment between these classifications.

This category is compatible with cases where the gender classification is based on self-identification or external attribution, provided that the resulting classification aligns with the person's female sex-at-birth record."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CisgenderPerson,
        hrio:FemaleGenderPerson,
        hrio:SexAtBirthFemaleSexPerson ;
    skos:prefLabel "Female Cisgender Person"@en .

hrio:FunctionalHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Functional Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Functional Health Condition is a category of Non-injury Health Condition used to group conditions characterized by an alteration in the functional performance of psychological, physiological, or bodily processes. Its placement under the non-structural axis highlights that the classification is based on how a health condition affects operation or activity, rather than on structural damage or the presence of an injury."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:NonStructuralHealthCondition ;
    skos:prefLabel "Functional Health Condition"@en .

hrio:Government a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Government"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment "A formal organization with authority to create, implement, and enforce laws and policies within a defined territory. Governments typically manage public services, maintain order, and regulate social and economic activities. They exercise unique legal powers, including issuing official documents, defining legal statuses, and recognizing individual rights."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Organization ;
    skos:prefLabel "Government"@en .

hrio:January a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:July a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:June a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:LaypersonDiagnosingAgent a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Layperson Diagnosing Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosing person whose professional status is layperson. The role applies when a person acts as a diagnosing agent without holding a professional status in the relevant domain."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:DiagnosingPerson ;
    skos:prefLabel "Layperson Diagnosing Agent"@en .

hrio:LegalFemaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Female-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose female gender classification is established through legal recognition, rather than through self-identification, gender expression, or external attribution.

A Legal Female-gender Person is a person whose legal gender is female. Such a person is characterized by one or more instances of Legal Female Gender, reflecting the legal designation of female gender that applies to the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:LegalFemaleGender ],
        hrio:AdministrativeFemaleGenderPerson ;
    skos:prefLabel "Legal Female-gender Person"@en .

hrio:LegalGenderRecognitionDocument a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Gender Recognition Document"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Legal Gender Recognition Document denotes an official document that records and formalizes one or more legal gender recognition acts. It provides the documentary basis associated with those recognitions, supporting the registration of the recognized legal gender for the relevant person in formal records."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:LegalGenderRecognition ],
        gufo:FunctionalComplex,
        hrio:AdministrativeGenderRecognitionDocument ;
    skos:prefLabel "Legal Gender Recognition Document"@en .

hrio:LegalGenderRecognizer a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Gender Recognizer"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition identifies the authorized recognizing party involved in legal gender recognition.

Legal Gender Recognizer denotes an authorized entity that performs legal gender recognition for persons. It is the recognizing party that participates in a recognition act and thereby acknowledges a legal gender for a person within the scope of formal legal recognition."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:LegalGenderRecognition ],
        hrio:AdministrativeGenderRecognizingOrganization,
        hrio:Government ;
    skos:prefLabel "Legal Gender Recognizer"@en .

hrio:LegalMaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Male-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose male gender classification is established through legal recognition, rather than through self-identification, gender expression, or external attribution.

A Legal Male-gender Person is a person whose legal gender is male. Such a person is characterized by one or more instances of Legal Male Gender, reflecting the legal designation of male gender that applies to the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:LegalMaleGender ],
        hrio:AdministrativeMaleGenderPerson ;
    skos:prefLabel "Legal Male-gender Person"@en .

hrio:LegalNonBinaryGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Non-binary-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose non-binary gender classification is established through legal recognition, rather than through self-identification, gender expression, or external attribution.

A Legal Non-binary-gender Person is a person whose legal gender is non-binary. Such a person is characterized by one or more instances of Legal Non-binary Gender, reflecting the legal designation of non-binary gender that applies to the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:LegalNonBinaryGender ],
        hrio:AdministrativeNonBinaryGenderPerson ;
    skos:prefLabel "Legal Non-binary-gender Person"@en .

hrio:LegallyUnassignedGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legally Unassigned Gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition characterizes the absence of a recognized legal gender assignment for a person within formal records.

Legally Unassigned Gender Person denotes a person for whom no legal gender is recorded as recognized in the relevant legal record or context. This role distinguishes persons lacking a recognized legal gender assignment from those whose legal gender has been formally recognized."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    skos:altLabel "Person with Unassigned Legal Gender"@en ;
    skos:prefLabel "Legally Unassigned Gender Person"@en .

hrio:LivingCellularEntity a gufo:PhaseMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Living Cellular Entity"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Living Cellular Entity is represented as a phase of a cellular entity characterized by the presence of biological activity. In the model it appears as part of a complete and disjoint partition of cellular entity states, capturing the condition in which cells, embryos, or organisms are biologically active. This class clarifies that the living state is explicitly represented in contrast to its dead counterpart."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CellularEntity ;
    skos:prefLabel "Living Cellular Entity"@en .

hrio:MaleCisgenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male Cisgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """Male Cisgender Person is a cisgender person whose recorded sex at birth is male and whose gender classification is male. It captures a form of cisgender modality grounded in alignment between these classifications.

This category is compatible with cases where the gender classification is based on self-identification or external attribution, provided that the resulting classification aligns with the person's male sex-at-birth record."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CisgenderPerson,
        hrio:MaleGenderPerson,
        hrio:SexAtBirthMaleSexPerson ;
    skos:prefLabel "Male Cisgender Person"@en .

hrio:March a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:May a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:NonSelfAwarePerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-self-aware Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Represents a phase of a Person lacking developed self-awareness. A Non-self-aware Person does not possess the cognitive capacity to recognize themselves as an individual or to reflect on their own mental states. This phase includes early developmental stages (such as infancy) or certain conditions that prevent the emergence of self-awareness."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:LivingPerson ;
    skos:prefLabel "Non-self-aware Person"@en .

hrio:November a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:October a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:Particular a gufo:Mixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Particular"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/UFO> ;
    rdfs:comment "Particular is the most general notion of an individual entity. It refers to any concrete, single entity that can be the bearer of properties and participate in relations."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:Endurant ;
    skos:prefLabel "Particular"@en .

hrio:PersonsDeath a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Person's Death"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Person's Death is a temporally bounded event in which an individual person's life ends. It marks the transition of that person from living to dead and stands in a termination relation to exactly one person."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:DeadPerson ;
            owl:onProperty [ owl:inverseOf gufo:wasTerminatedIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        gufo:Event ;
    skos:prefLabel "Person's Death"@en .

hrio:PhenotypicSexAssessor a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Sex Assessor"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Refers to the role of the healthcare professional responsible for evaluating a person's phenotypic sex. This role involves clinical judgment and interpretation of anatomical features."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty gufo:mediates ;
            owl:someValuesFrom hrio:PhenotypicSexAssessment ],
        hrio:HealthcareProfessional ;
    skos:prefLabel "Phenotypic Sex Assessor"@en .

hrio:Polyploid a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Polyploid"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HumanCell ;
    skos:prefLabel "Polyploid"@en .

hrio:PreferredPronoun a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Preferred Pronoun"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Preferred Pronoun is a quality with a string value used to record a pronoun a person prefers to be addressed with. Values are not restricted to a predefined list, and a person may be associated with zero or more preferred pronoun values."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:Quality ;
    skos:prefLabel "Preferred Pronoun"@en .

hrio:ProfessionalDiagnosingAgent a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Professional Diagnosing Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosing person whose professional status is professional. The role applies when a person acts as a diagnosing agent with a recognized professional status in the relevant domain."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:DiagnosingPerson ;
    skos:prefLabel "Professional Diagnosing Agent"@en .

hrio:PsychologicalHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Psychological Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment """Psychological Health Condition is a category of Non-injury Health Condition used to classify conditions by their primary psychological manifestation within the model's non-structural axis. It groups health conditions whose salient features concern mental, affective, cognitive, or behavioral aspects rather than structural tissue damage or an injury event.

Placement in this hierarchy does not determine etiology, dependence, or origin. A Psychological Health Condition may also be specialized along those other axes where applicable in the diagrams, since the generalization sets there can be complete and overlapping. The category therefore provides a focused, non-injury, non-structural reading of a condition while remaining compatible with the other classifications present in the model."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:NonInjuryHealthCondition,
        hrio:NonStructuralHealthCondition ;
    skos:prefLabel "Psychological Health Condition"@en .

hrio:ResearchDiagnosis a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Research Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A healthcare diagnosis whose use is oriented to research. It serves as a diagnostic assertion used to support study design, data analysis, or methodological evaluation, rather than to guide direct care for a specific patient."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Research Diagnosis"@en .

hrio:SelfIdentifiedCisgenderFemalePerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Cisgender Female Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """A Self-identified Cisgender Female Person is a person who self-identifies as cisgender and as female.

This class applies when the person's self-identified female gender is consistent with the person's female sex at birth, so the cisgender status is grounded in self-identification rather than in external attribution."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SelfIdentifiedCisgenderPerson,
        hrio:SelfIdentifiedFemaleGenderPerson,
        hrio:SexAtBirthFemaleSexPerson ;
    skos:prefLabel "Self-identified Cisgender Female Person"@en .

hrio:SelfIdentifiedCisgenderMalePerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Cisgender Male Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """A Self-identified Cisgender Male Person is a person who self-identifies as cisgender and as male.

This class applies when the person's self-identified male gender is consistent with the person's male sex at birth, so the cisgender status is grounded in self-identification rather than in external attribution."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SelfIdentifiedCisgenderPerson,
        hrio:SelfIdentifiedMaleGenderPerson,
        hrio:SexAtBirthMaleSexPerson ;
    skos:prefLabel "Self-identified Cisgender Male Person"@en .

hrio:September a hrio:Month ;
    rdf:label "[object Object]" ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:SexAtBirthAssigner a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex at Birth Assigner"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Represents the role of professionals authorized to make and record the sex assignment at birth, typically including clinicians such as doctors or midwives who perform the observation and formal documentation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:SexAtBirthAssignment ],
        hrio:HealthcareProfessional ;
    skos:prefLabel "Sex at Birth Assigner"@en .

hrio:SexAtBirthUnassignedPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth-unassigned Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Represents individuals who, at the point of registration, do not have a formally recorded sex assignment. This acknowledges the possibility of cases where no clear classification is made, recognizing flexibility in administrative processes."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    skos:prefLabel "Sex-at-birth-unassigned Person"@en .

hrio:SurveillanceDiagnosis a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Surveillance Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A healthcare diagnosis whose use is oriented to surveillance. It functions as a diagnostic assertion used for monitoring, reporting, or population-level oversight, rather than for immediate care decisions about a specific patient."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Surveillance Diagnosis"@en .

hrio:administrativeFemaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:externallyAttributedFemaleGenderPerson .

hrio:administrativeGenderInheresInAdministrativelyRecognizedGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:externallyGenderAttributedPersonInheresInExternallyAttributedGender .

hrio:administrativeMaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:externallyAttributedMaleGenderPerson .

hrio:administrativeNonBinaryGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:externallyAttributedNonBinaryGenderPerson .

hrio:attributedTo rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:attributesGender rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:conditionInheresInSubstantial rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:externallyAttributedFemaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:femaleGenderInheresInFemaleGenderPerson .

hrio:externallyAttributedMaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:maleGenderInheresInMaleGenderPerson .

hrio:externallyAttributedNonBinaryGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:nonBinaryGenderInheresInNonBinaryGenderPerson .

hrio:externallyGenderAttributedPersonInheresInExternallyAttributedGender rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_1 .

hrio:hasAttributor rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:indeterminateSexInheresInIndeterminateSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:nonBinaryPerson,
        hrio:sexInheresInPerson .

hrio:isBornIn rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:phenotypicAmbiguousSexInheresInPhenotypicAmbiguousSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:indeterminateSexInheresInIndeterminateSexPerson,
        hrio:phenotypicSexInheresInPhenotypicSexAssessedPerson .

hrio:phenotypicFemaleSexInheresInPhenotypicFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:femaleSexInheresInFemaleSexPerson,
        hrio:phenotypicSexInheresInPhenotypicSexAssessedPerson .

hrio:phenotypicMaleSexInheresInPhenotypicMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:maleSexInheresInMaleSexPerson,
        hrio:phenotypicSexInheresInPhenotypicSexAssessedPerson .

hrio:recognizedBy rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:hasAttributor .

hrio:recognizesGender rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:attributesGender .

hrio:recognizes_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:attributedTo .

hrio:AcquiredHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Acquired Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Acquired Health Condition is a category used to denote health conditions that develop after birth. In the model, it is treated as a subtype of known-origin conditions, emphasizing that their identifiable cause emerges during the individual's life course. This classification complements congenital conditions by capturing the contrast between pre-birth and post-birth origins of known health conditions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyCausedHealthCondition,
        hrio:KnownOriginHealthCondition ;
    skos:prefLabel "Acquired Health Condition"@en .

hrio:AddressablePlace a gufo:Mixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Addressable Place"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """Addressable Place is a place considered specifically under the aspect of being addressable, that is, being the target of an Address used to refer to it in a stable and communicable way.

Each Addressable Place is characterized by one or more Addresses, and an Address may characterize one or more Addressable Places, reflecting that the same address information can be applied to multiple places when they are treated as addressable within the same addressing context."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Address ],
        gufo:FunctionalComplex ;
    skos:altLabel "Addressable Location"@en,
        "Place With Address"@en ;
    skos:prefLabel "Addressable Place"@en .

hrio:AdministrativeCodingDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Coding Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "Administrative Coding Diagnosis is a Healthcare Diagnosis defined by having an administrative coding record as its source. The diagnostic statement is taken from the administrative code representation rather than from clinical examination, laboratory measurement, or imaging as sources."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Administrative Coding Diagnosis"@en .

hrio:AdministrativeFemaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Female-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Administrative Female-gender Person is a person whose administrative gender assignment is female. This classification concerns an administrative recognition of a female gender for the person, as established by an organization acting as an administrative gender recognizer and recorded through an administrative gender recognition.

The class is intended to capture the administrative status of a female gender assignment, independently of how the person identifies or expresses gender or how others may attribute gender in non-administrative contexts."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:AdministrativeFemaleGender ],
        hrio:ExternallyAttributedFemaleGenderPerson ;
    skos:prefLabel "Administrative Female-gender Person"@en .

hrio:AdministrativeGenderRecognitionAgent a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Gender Recognition Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Gender Recognition Agent is an individual who acts on behalf of an Administrative Gender Recognizing Organization in the context of an Administrative Gender Recognition. The agent is mediated by one or more Administrative Gender Recognitions and is created by a recognizing organization to operate on its behalf."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty gufo:mediates ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognition ],
        hrio:IndividualAgent ;
    skos:prefLabel "Administrative Gender Recognition Agent"@en .

hrio:AdministrativeGenderRecognitionDocument a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Gender Recognition Document"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """Administrative Gender Recognition Document is a documentary artifact that records an administrative gender recognition and the administrative gender designation recognized for a person. It is created by an administrative gender recognition agent and participates in the recognition or recognitions it records.

The document provides the administrative record that ties a recognition act to its recorded administrative gender outcome."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognition ],
        hrio:Document ;
    skos:prefLabel "Administrative Gender Recognition Document"@en .

hrio:AdministrativeMaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Male-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Administrative Male-gender Person is a person whose administrative gender assignment is male. This classification concerns an administrative recognition of a male gender for the person, as established by an organization acting as an administrative gender recognizer and recorded through an administrative gender recognition.

The class is intended to capture the administrative status of a male gender assignment, independently of how the person identifies or expresses gender or how others may attribute gender in non-administrative contexts."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:AdministrativeMaleGender ],
        hrio:ExternallyAttributedMaleGenderPerson ;
    skos:prefLabel "Administrative Male-gender Person"@en .

hrio:AdministrativeNonBinaryGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Non-binary-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Administrative Non-binary-gender Person is a person whose administrative gender assignment is non-binary. This classification concerns an administrative recognition of a non-binary gender for the person, as established by an organization acting as an administrative gender recognizer and recorded through an administrative gender recognition.

The class is intended to capture the administrative status of a non-binary gender assignment, independently of how the person identifies or expresses gender or how others may attribute gender in non-administrative contexts."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:AdministrativeNonBinaryGender ],
        hrio:ExternallyAttributedNonBinaryGenderPerson ;
    skos:prefLabel "Administrative Non-binary-gender Person"@en .

hrio:AllosomeX a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Allosome X"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Allosome X is a subkind of Allosome representing the X chromosome. It contains a large number of genes, many of which are not directly related to sex determination but are essential for general biological functions. The X chromosome is present in both males and females, typically as XX in females and as XY in males."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Allosome ;
    skos:prefLabel "Allosome X"@en .

hrio:AllosomeY a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Allosome Y"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Allosome Y is a subkind of Allosome representing the Y chromosome. It carries genes critical for initiating male sex differentiation and development but contains fewer genes than the X chromosome. In viable human cells, the Y chromosome never occurs alone and must be paired with at least one X chromosome."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Allosome ;
    skos:prefLabel "Allosome Y"@en .

hrio:AntemortemDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Antemortem Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "Antemortem Diagnosis is a Cellular Entity Diagnosis concerning material obtained from a living organism before death. The temporal qualifier applies to the organism's life status at specimen collection or observation time, regardless of when the diagnostic conclusion is formulated, and contrasts with Postmortem Diagnosis in the same set."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CellularEntityDiagnosis ;
    skos:prefLabel "Antemortem Diagnosis"@en .

hrio:Belief a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Belief"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A general type of mental state that can characterize an agent and guide reasoning about a situation. In the diagnostic context it serves as the common category for the beliefs that arise during or from diagnostic activities.

Belief subsumes Diagnosis Suspicion and Diagnostic Assessment Outcome as specialized kinds of belief used in the model. The class captures the agent's cognitive stance without itself committing to whether that stance is correct or incorrect."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:IntrinsicMode ;
    skos:prefLabel "Belief"@en .

hrio:CellularEntityDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Cellular Entity Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosis whose focus is a cellular entity as the diagnosed entity, rather than an organism-level subject. It organizes diagnosis types that concern cellular-level objects and is separate from organism-focused healthcare diagnosis types."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PostmortemDiagnosis hrio:AntemortemDiagnosis ) ] ;
    skos:prefLabel "Cellular Entity Diagnosis"@en .

hrio:ClinicalDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Clinical Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "Clinical Diagnosis is a Healthcare Diagnosis whose source is clinical evaluation of the individual, grounded primarily in history, signs, and examination, possibly considering test results. Its scope is distinguished from diagnoses whose source is exclusively laboratory, imaging, or administrative coding."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Clinical Diagnosis"@en .

hrio:CongenitalHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Congenital Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Congenital Health Condition is a category used to denote health conditions that are present at birth. In the model, it is treated as a subtype of known-origin conditions, emphasizing that their identifiable cause lies in factors affecting development before or during birth. This classification situates congenital conditions within the broader framework of etiological distinctions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:KnownOriginHealthCondition,
        hrio:NonTraumaticHealthCondition ;
    skos:prefLabel "Congenital Health Condition"@en .

hrio:DiagnosticMethod a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnostic Method"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A mode that characterizes a diagnostic relation by specifying the concrete procedure or approach applied in that relation. Each diagnostic method instantiates a diagnostic method type that classifies the kind of procedure used."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:DiagnosticRelation ;
            owl:onProperty gufo:inheresIn ],
        gufo:ExtrinsicMode ;
    skos:prefLabel "Diagnostic Method"@en .

hrio:DigitalDocument a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Digital Document"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A document whose embodiment is digital. Its content is represented in an electronic information structure that can be stored, processed, or transmitted by computing systems. The definition is independent of any specific file format or storage technology.

Digital Document specializes Document and is disjoint from Physical Document."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:Document ;
    skos:prefLabel "Digital Document"@en .

hrio:EpidemiologicalDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Epidemiological Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "Epidemiological Diagnosis is a Healthcare Diagnosis defined by reliance on an epidemiological case definition as its source. The diagnostic assertion is derived from population-oriented criteria specified in the case definition, rather than from individual laboratory, imaging, or administrative coding sources."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Epidemiological Diagnosis"@en .

hrio:ExternallyAttributedTransgenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Transgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Externally-attributed Transgender Person is a person assigned a transgender modality through external attribution. It captures transgender classification as assigned by an external party, distinct from transgender classification grounded in self-identification."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyGenderAttributedPerson,
        hrio:TransgenderPerson ;
    skos:prefLabel "Externally-attributed Transgender Person"@en .

hrio:FemaleTypicalDimorphicCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female-typical Dimorphic Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    rdfs:comment "Includes anatomical or physiological traits more typical of females, such as wider pelvic structure or distribution of body fat. These traits inform classification into the female category."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SexualDimorphicCharacteristic ;
    skos:prefLabel "Female-typical Dimorphic Characteristic"@en .

hrio:FemaleTypicalVisualSexCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female-typical Visual Sex Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Encompasses anatomical features typically associated with females, such as breast development, pelvic shape, or distribution of body fat."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:VisualSexCharacteristic ;
    skos:prefLabel "Female-typical Visual Sex Characteristic"@en .

hrio:FemininePresentingPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Feminine-presenting Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """Feminine-presenting Person is a Female-gender Person whose gender expression is characterized as feminine. It captures cases where a person is characterized within the female gender outcome while presenting in ways commonly interpreted as feminine.

This category concerns presentation or expression and does not, by itself, imply any particular sex-at-birth classification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:FeminineGenderExpression ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:FemaleGenderPerson ;
    skos:prefLabel "Feminine-presenting Person"@en .

hrio:GenderAttributor a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gender Attributor"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "A gender attributor is an individual agent who participates as the attributor in one or more gender attributions directed at an externally gender-attributed person. The attributor is the source participant of the attribution and, in each attribution, is distinct from the person to whom the attribution is directed."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:GenderAttribution ;
            owl:onProperty gufo:mediates ],
        gufo:FunctionalComplex,
        hrio:Agent ;
    skos:prefLabel "Gender Attributor"@en .

hrio:GeneticFather a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Genetic Father"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Genetic Father is a role played by a Person who is the genetic (paternal) parent of another Person (the offspring). In this model, each Person is related to exactly one Genetic Father, while the same Genetic Father may be related to one or more Persons, typically via Birth Biological Provenance.

Genetic Fatherhood captures biological/genetic parentage (not legal or social parentage). Modeling constraint: Genetic Father is specialized from Karyotypic Male-sex Person, reflecting an explicit restriction adopted in this model."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:BirthBiologicalProvenance ;
            owl:onProperty gufo:mediates ],
        hrio:KaryotypicMaleSexPerson ;
    skos:altLabel "Genetic Paternal Parent"@en,
        "Paternal Genetic Parent"@en ;
    skos:prefLabel "Genetic Father"@en .

hrio:GeneticMother a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Genetic Mother"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Genetic Mother is a role played by a Person who is the genetic (maternal) parent of another Person (the offspring). In this model, each Person is related to exactly one Genetic Mother, while the same Genetic Mother may be related to one or more Persons, typically via Birth Biological Provenance.

Genetic Motherhood captures biological/genetic parentage (not legal or social parentage) and is distinct from the Gestational Carrier role, which concerns gestation. Modeling constraint: Genetic Mother is specialized from Karyotypic Female-sex Person, reflecting an explicit restriction adopted in this model."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:BirthBiologicalProvenance ;
            owl:onProperty gufo:mediates ],
        hrio:KaryotypicFemaleSexPerson ;
    skos:altLabel "Genetic Maternal Parent"@en,
        "Maternal Genetic Parent"@en ;
    skos:prefLabel "Genetic Mother"@en .

hrio:GestationalCarrier a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gestational Carrier"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Gestational Carrier (historical role) is the role played by a Person who carried the pregnancy/gestation that culminated in a Birth.

In this model, each Birth is associated with exactly one Gestational Carrier, and each Gestational Carrier is associated with one or more Births. Gestational Carrier is linked to Birth Biological Provenance via participation in that relator (each provenance is associated with exactly one Gestational Carrier, and each Gestational Carrier is linked to one or more provenances).

Model assumption: only karyotypic female-sex persons can instantiate Gestational Carrier."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:BirthBiologicalProvenance ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:onProperty gufo:participatedIn ;
            owl:someValuesFrom hrio:Birth ],
        hrio:KaryotypicFemaleSexPerson ;
    skos:altLabel "Gestation Carrier"@en,
        "Gestational Mother"@en,
        "Pregnancy Carrier"@en ;
    skos:prefLabel "Gestational Carrier"@en .

hrio:HaploidCell a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Haploid Cell"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Haploid Cell is a human cell that contains a single set of chromosomes. It is modeled as a subkind of Human Cell, disjoint and complete with the diploid alternative, and participates in the componentOf relation with chromosomes. Its reduced chromosomal count is essential for distinguishing it from diploid cells, and in the model it also serves as the basis from which gametes are defined."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HumanCell ;
    skos:prefLabel "Haploid Cell"@en .

hrio:HealthcareProfessional a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Healthcare Professional"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Represents any trained and authorized individual who provides medical or health-related services. This includes doctors, nurses, midwives, and other clinicians involved in patient care. In the context of this model, healthcare professionals carry out assessments, make observations, and record classifications such as phenotypic sex at birth, but their role more broadly encompasses diagnosis, treatment, counseling, and support for overall health and well-being."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    skos:prefLabel "Healthcare Professional"@en .

hrio:HumanHealthcareDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Human Healthcare Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosis concerning a human patient in a healthcare context. Its scope is human health rather than veterinary care."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Human Healthcare Diagnosis"@en .

hrio:IdiopathicHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Idiopathic Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Idiopathic Health Condition is a category used to represent health conditions for which no specific cause can be identified. In the model, it is contrasted with conditions of known origin, highlighting the absence of a clear etiological explanation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition,
        hrio:NonTraumaticHealthCondition ;
    skos:prefLabel "Idiopathic Health Condition"@en .

hrio:InconclusiveDiagnosticAssessment a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Inconclusive Diagnostic Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnostic assessment that does not reach a definitive determination. It completes without yielding a conclusive diagnostic assessment outcome."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:DiagnosticAssessment ;
    skos:prefLabel "Inconclusive Diagnostic Assessment"@en .

hrio:IndeterminateDimorphicCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Indeterminate Dimorphic Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    rdfs:comment "Captures traits that do not clearly align with typical male or female patterns. It supports the recognition of biological diversity and variation beyond the binary model."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SexualDimorphicCharacteristic ;
    skos:prefLabel "Indeterminate Dimorphic Characteristic"@en .

hrio:IndeterminateVisualSexCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Indeterminate Visual Sex Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Captures anatomical features that do not clearly align with male-typical or female-typical categories. This classification supports recognizing and documenting variations beyond the binary model."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:VisualSexCharacteristic ;
    skos:prefLabel "Indeterminate Visual Sex Characteristic"@en .

hrio:Injury a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Injury"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Injury is a category used to represent health conditions that result from traumatic events or exposures. In the model, it is treated as a subtype of externally-caused health conditions, with trauma or harmful exposure identified as the relevant basis for its occurrence."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyCausedHealthCondition ;
    skos:prefLabel "Injury"@en .

hrio:KaryotypicalIndeterminatePerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypical Indeterminate Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Captures cases where the chromosomal composition does not allow clear classification as male or female. This category acknowledges the existence of complex or ambiguous chromosomal patterns that do not fit binary definitions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:PersonWithVariantSexChromosome ;
    skos:prefLabel "Karyotypical Indeterminate Person"@en .

hrio:LaboratoryDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Laboratory Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A healthcare diagnosis established primarily from laboratory analyses of specimens such as blood or tissue."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Laboratory Diagnosis"@en .

hrio:LegalFemaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Female Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Legal Female Gender is a legal gender characterization in which a person is legally recognized as female. It captures the legal gender status assigned through legal gender recognition and recorded in the corresponding legal gender recognition documentation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalFemaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeFemaleGender,
        hrio:FemaleGender,
        hrio:LegalGender ;
    skos:prefLabel "Legal Female Gender"@en .

hrio:LegalMaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Male Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Legal Male Gender is a legal gender characterization in which a person is legally recognized as male. It captures the legal gender status assigned through legal gender recognition and recorded in the corresponding legal gender recognition documentation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalMaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeMaleGender,
        hrio:LegalGender,
        hrio:MaleGender ;
    skos:prefLabel "Legal Male Gender"@en .

hrio:LegalNonBinaryGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Non-binary Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Legal Non-binary Gender is a legal gender characterization in which a person is legally recognized as non-binary. It captures the legal gender status assigned through legal gender recognition and recorded in the corresponding legal gender recognition documentation."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalNonBinaryGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeNonBinaryGender,
        hrio:LegalGender,
        hrio:NonBinaryGender ;
    skos:prefLabel "Legal Non-binary Gender"@en .

hrio:MaleTypicalDimorphicCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male-typical Dimorphic Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    rdfs:comment "Represents specific anatomical or physiological traits that are statistically more common or pronounced in males. Examples might include broader shoulders or denser facial hair."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SexualDimorphicCharacteristic ;
    skos:prefLabel "Male-typical Dimorphic Characteristic"@en .

hrio:MaleTypicalVisualSexCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male-typical Visual Sex Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Includes anatomical features statistically more common or pronounced in males, such as external genitalia shape, body hair distribution, or certain skeletal structures."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:VisualSexCharacteristic ;
    skos:prefLabel "Male-typical Visual Sex Characteristic"@en .

hrio:MasculinePresentingPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Masculine-presenting Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """Masculine-presenting Person is a Male-gender Person whose gender expression is characterized as masculine. It captures cases where a person is characterized within the male gender outcome while presenting in ways commonly interpreted as masculine.

This category concerns presentation or expression and does not, by itself, imply any particular sex-at-birth classification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:MasculineGenderExpression ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:MaleGenderPerson ;
    skos:prefLabel "Masculine-presenting Person"@en .

hrio:NonBinaryPresentingPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary-presenting Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """Non-binary-presenting Person is a Non-binary-gender Person whose gender expression is characterized as non-binary. It captures cases where a person is characterized within the non-binary gender outcome while presenting in ways commonly interpreted as non-binary.

This category concerns presentation or expression and does not, by itself, imply any particular sex-at-birth classification."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:NonBinaryGenderExpression ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:NonBinaryGenderPerson ;
    skos:prefLabel "Non-binary-presenting Person"@en .

hrio:NonHumanAnimal a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-Human Animal"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment """The class /Non-Human Animal represents every animal that is not a Person. It is modeled as the complement of the class Person with respect to the more general class Animal. This includes all biological animals outside the human species, independent of their specific taxonomy or characteristics.

The class abstracts from distinctions among different animal groups, serving instead to delimit the scope of Person within the Animal category. It ensures that the ontology can clearly separate human individuals from all other animals, while still maintaining their common status as animals under the broader hierarchy."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Animal ;
    skos:prefLabel "Non-Human Animal"@en .

hrio:NonPathologicalHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-Pathological Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Non-Pathological Health Condition is represented as a condition that does not fall under the pathological category. It complements pathological health conditions as part of a complete and disjoint partition, ensuring that the ontology accounts for conditions that may affect health without being classified as pathological."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthCondition ;
    skos:prefLabel "Non-Pathological Health Condition"@en .

hrio:Object a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Object"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/UFO> ;
    rdfs:comment "Object is a substantial that lacks agency. It is the non-agentive counterpart to Agent and captures material or conceptual individuals that do not act as agents."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:Substantial ;
    skos:prefLabel "Object"@en .

hrio:PersonsDeathCause a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Person's Death Cause"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Person's Death Cause is the specific cause attributed to a dead person. It characterizes exactly one dead person and is an instance of exactly one Person's Death Cause Type; a type may correspond to many concrete death causes."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:DeadPerson ;
            owl:onProperty gufo:inheresIn ],
        gufo:IntrinsicMode ;
    skos:prefLabel "Person's Death Cause"@en .

hrio:PhenotypicSexAssessment a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Sex Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Represents the structured process through which a person's phenotypic sex is evaluated and categorized. It involves the interaction between the healthcare professional (assessor) and the individual being assessed."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:PhenotypicSexAssessor ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PhenotypicSexAssessedPerson ;
            owl:onProperty gufo:mediates ],
        gufo:Relator ;
    skos:prefLabel "Phenotypic Sex Assessment"@en .

hrio:PhysicalDocument a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Physical Document"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A document whose embodiment is a tangible artifact. Its content is carried by a physical medium that is created, stored, and exchanged through physical handling. The definition is independent of the particular material used.

Physical Document specializes Document and is disjoint from Digital Document."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:Document ;
    skos:prefLabel "Physical Document"@en .

hrio:PostmortemDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Postmortem Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosis established after the death of the organism to which it refers. It contrasts with Antemortem Diagnosis by being determined in a post-death context."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CellularEntityDiagnosis ;
    skos:prefLabel "Postmortem Diagnosis"@en .

hrio:RadiologicalDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Radiological Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A healthcare diagnosis for which the determining evidence originates from diagnostic imaging performed by radiology. Typical sources include X-ray, CT, and MRI images."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Radiological Diagnosis"@en .

hrio:RiskBasedHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Risk-based Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Risk-based Health Condition is represented as a condition that captures the probability or predisposition of future illness rather than an existing disorder. In the model it complements established health conditions, ensuring that the ontology incorporates preventive and epidemiological perspectives alongside diagnostic ones."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:IntrinsicMode,
        hrio:HealthCondition ;
    skos:prefLabel "Risk-based Health Condition"@en .

hrio:SelfDesignatedGender a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-designated Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Self-designated Gender is a general category for gender characteristics designated by the person. It includes self-identified gender and gender expression as distinct forms of self-designation used to represent how a person identifies and how a person expresses gender."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:IntrinsicMode,
        hrio:Gender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:GenderExpression hrio:SelfIdentifiedGender ) ] ;
    skos:prefLabel "Self-designated Gender"@en .

hrio:SelfIdentifiedTransgenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Transgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Self-identified Transgender Person is a self-aware person who self-identifies as transgender. It is mutually exclusive with Self-identified Cisgender Person and together they classify self-aware persons by self-identified gender modality, while allowing externally attributed transgender classifications to also apply to the same person."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SelfAwarePerson,
        hrio:TransgenderPerson ;
    skos:prefLabel "Self-identified Transgender Person"@en .

hrio:SexAtBirthIndeterminateSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Indeterminate-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Includes individuals whose sex at birth is formally recorded as indeterminate. This category supports administrative recognition of cases where observed features do not clearly fit male or female classifications."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirthIndeterminateSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:PhenotypicAmbiguousSexPerson,
        hrio:SexAtBirthAssignedPerson ;
    skos:prefLabel "Sex-at-birth Indeterminate-sex Person"@en .

hrio:SingletonBirth a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Singleton Birth"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Scope: definition of Singleton Birth and its distinction from Multiple Birth Component.

Singleton Birth is a Single Birth that is not a component of any Multiple Birth (i.e., a standalone delivery of exactly one offspring). Singleton Birth and Multiple Birth Component form a Disjoint and Covering partition of Single Birth (�single birth type�), so every Single Birth is exactly one of these two specializations."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SingleBirth ;
    skos:altLabel "Non-component Single Birth"@en,
        "Non-multiple Single Birth"@en ;
    skos:prefLabel "Singleton Birth"@en .

hrio:StructuralHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Structural Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Structural Health Condition is a category of Non-injury Health Condition used to group conditions identified by structural manifestations in tissues, organs, or other physical components of the body. Its role in the model is to emphasize that a health condition may be classified by its material or anatomical expression, independent of its etiology or dependence relations. This structural axis provides a complementary view to the functional classification, allowing conditions to be interpreted within multiple overlapping categories as specified in the diagrams."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition ;
    skos:prefLabel "Structural Health Condition"@en .

hrio:TraumaticHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Traumatic Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Traumatic Health Condition is a category used to describe health conditions that result from traumatic events, such as physical injuries or exposure to harmful forces. In the model, it serves to contrast with non-traumatic cases by emphasizing the causal role of trauma in the condition's origin."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition,
        hrio:Injury ;
    skos:prefLabel "Traumatic Health Condition"@en .

hrio:VeterinaryDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Veterinary Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnosis concerning non-human animals within veterinary care. Its scope is animal health and care rather than human healthcare."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthcareDiagnosis ;
    skos:prefLabel "Veterinary Diagnosis"@en .

hrio:femaleSexInheresInFemaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexInheresInPerson,
        hrio:woman .

hrio:maleSexInheresInMaleSexPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:man,
        hrio:sexInheresInPerson .

hrio:man rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_2 .

hrio:nonBinaryPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_2 .

<https://w3id.org/health-ri/ontology#package/SexAndGender> a skos:Collection ;
    rdfs:label "Sex and Gender"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "erv" ;
    skos:prefLabel "Sex and Gender"@en .

hrio:person rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_1 .

hrio:personInheresInKaryotypicSex rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexInheresInPerson .

hrio:woman rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_2 .

hrio:AdministrativeFemaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Female Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Female Gender is a female gender designation recognized through an administrative process. It represents an officially recorded female gender classification for a person, as established by an organization acting as an administrative gender recognizer. The administrative designation may or may not coincide with the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativeFemaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeGender,
        hrio:ExternallyAttributedFemaleGender,
        hrio:FemaleGender ;
    skos:altLabel "Civil Registry Female Gender Marker"@en,
        "F Designation"@en,
        "F Gender Marker"@en,
        "Female Gender Marker"@en,
        "Population Register Female Gender Marker"@en,
        "Recorded As Female"@en,
        "Registered As Female"@en,
        "Registry Female Gender Marker"@en ;
    skos:prefLabel "Administrative Female Gender"@en .

hrio:AdministrativeGenderRecognizingOrganization a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Gender Recognizing Organization"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Gender Recognizing Organization is the organizational role of the authority that recognizes a person's administrative gender. It participates in an Administrative Gender Recognition as the recognizing organization and may delegate operational activities to an Administrative Gender Recognition Agent that acts on its behalf, including creating the associated recognition document."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognition ],
        hrio:GenderAttributor,
        hrio:Organization ;
    skos:prefLabel "Administrative Gender Recognizing Organization"@en .

hrio:AdministrativeMaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Male Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Male Gender is a male gender designation recognized through an administrative process. It represents an officially recorded male gender classification for a person, as established by an organization acting as an administrative gender recognizer. The administrative designation may or may not coincide with the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativeMaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeGender,
        hrio:ExternallyAttributedMaleGender,
        hrio:MaleGender ;
    skos:altLabel "Civil Registry Male Gender Marker"@en,
        "M Designation"@en,
        "M Gender Marker"@en,
        "Male Gender Marker"@en,
        "Population Register Male Gender Marker"@en,
        "Recorded As Male"@en,
        "Registered As Male"@en,
        "Registry Male Gender Marker"@en ;
    skos:prefLabel "Administrative Male Gender"@en .

hrio:AdministrativeNonBinaryGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Non-binary Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Non-binary Gender is a non-binary gender designation recognized through an administrative process. It represents an officially recorded non-binary gender classification for a person, as established by an organization acting as an administrative gender recognizer. The administrative designation may or may not coincide with the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativeNonBinaryGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativeGender,
        hrio:ExternallyAttributedNonBinaryGender,
        hrio:NonBinaryGender ;
    skos:altLabel "Civil Registry Non-binary Gender Marker"@en,
        "Non-binary Gender Marker"@en,
        "Population Register Non-binary Gender Marker"@en,
        "Recorded As Non-binary"@en,
        "Registered As Non-binary"@en,
        "Registry Non-binary Gender Marker"@en,
        "X Designation"@en,
        "X Gender Marker"@en ;
    skos:prefLabel "Administrative Non-binary Gender"@en .

hrio:AdministrativelyRecognizedGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administratively Recognized Gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "This definition describes the person role tied to an administratively recognized gender assignment. Administratively Recognized Gender Person denotes a person who is the target of an administrative gender recognition act and thereby has an administrative gender acknowledged for administrative purposes. This role captures that the relevant administrative gender is established through an attribution or recognition act rather than solely through self-identification or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognition ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:AdministrativeGender ],
        hrio:ExternallyGenderAttributedPerson,
        hrio:Person ;
    skos:altLabel "Person with Recognized Administrative Gender"@en ;
    skos:prefLabel "Administratively Recognized Gender Person"@en .

hrio:Allosome a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Allosome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Allosome is a subkind of Chromosome that denotes the sex chromosomes present in human cells. Allosomes are responsible for determining chromosomal sex and also contribute to sexual development and related biological traits. In humans, diploid cells typically contain two allosomes, which may occur in the combinations XX or XY."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Chromosome ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:AllosomeX hrio:AllosomeY ) ] ;
    skos:prefLabel "Allosome"@en .

hrio:Animal a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Animal"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "An Animal is represented as a general category that specializes Cellular Entity and provides the basis for distinguishing humans from other living beings. In the model it subsumes both persons and non-human animals, forming a complete and disjoint partition of animal types. As a biological entity, it is also connected to the representation of health conditions, ensuring that conditions are grounded in organisms with a cellular structure. In addition, Animal is modeled as a type of agent, allowing it to participate in actions and interactions alongside other agents such as organizations and artificial agents. This position highlights its dual role as both a biological and an agentive category within the ontology."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:HealthCondition ;
            owl:onProperty gufo:inheresIn ],
        hrio:Agent,
        hrio:CellularEntity,
        hrio:Substantial ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Person hrio:NonHumanAnimal ) ] ;
    skos:prefLabel "Animal"@en .

hrio:ArtificialAgent a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Artificial Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """An individual agent realized by an artifact-based system rather than by a human person. It falls under the broader class Agent and under Individual Agent, and is disjoint from Person in the individual-agent partition. The class serves as a common type for machines or software-controlled systems that can act, perceive, or decide in ways that count as agency for the purposes of this model.

Artificial Agent provides the basis for role-specific specializations in particular contexts. For example, when participating in diagnostic activities an instance can instantiate the Diagnosing Artificial Agent role."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:IndividualAgent ;
    skos:prefLabel "Artificial Agent"@en .

hrio:Cisgender a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Cisgender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """Cisgender is a gender modality that characterizes a person as cisgender in a given modality context.

It captures alignment between the person's sex at birth assignment and the person's gender outcome as established in that context, including contexts grounded in self-identification and external attribution."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:CisgenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:GenderModality ;
    skos:prefLabel "Cisgender"@en .

hrio:DeadPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Dead Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Dead Person denotes the life-status phase of a person whose life has ended. This phase begins at exactly one Person's Death event and is mutually exclusive with being a Living Person. Each dead person is characterized by exactly one Person's Death Cause."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:PersonsDeathCause ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:onClass hrio:PersonsDeath ;
            owl:onProperty gufo:wasTerminatedIn ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:Person ;
    skos:prefLabel "Dead Person"@en .

hrio:DiagnosingPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosing Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A person that bears the diagnosing role in a diagnostic process. This role may be taken by individuals with different professional statuses, which are further specialized as layperson or professional diagnosing agents."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:DiagnosingAgent,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ProfessionalDiagnosingAgent hrio:LaypersonDiagnosingAgent ) ] ;
    skos:prefLabel "Diagnosing Person"@en .

hrio:DiagnosticAssessment a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnostic Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "An event in which a diagnostic process is carried out to determine an assessment result type. It manifests a concluded diagnostic relation and may yield a diagnostic assessment outcome that characterizes the result."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ConcludedDiagnosticRelation ;
            owl:onProperty [ owl:inverseOf gufo:manifestedIn ] ],
        gufo:Event ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ConclusiveDiagnosticAssessment hrio:InconclusiveDiagnosticAssessment ) ] ;
    skos:prefLabel "Diagnostic Assessment"@en .

hrio:DiagnosticAssessmentOutcome a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnostic Assessment Outcome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A mode that records the result of a diagnostic assessment. It is the issued outcome of the assessment and can be of different kinds, such as a Diagnosis or a No-Diagnosis Outcome, reflecting the conclusive determination reached by the diagnosing process. Each outcome is issued by an agent acting as a Diagnostic Outcome Issuer."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:DiagnosticOutcomeIssuer ;
            owl:onProperty gufo:inheresIn ],
        hrio:Belief ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Diagnosis hrio:NoDiagnosisOutcome ) ] ;
    skos:prefLabel "Diagnostic Assessment Outcome"@en .

hrio:Document a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Document"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment "A recorded piece of information that can be stored, shared, and referenced, regardless of medium. Documents serve as authoritative records of facts, decisions, or transactions and can exist in physical or digital form. They are used to communicate, formalize, and preserve information across contexts such as administration, law, business, and personal records."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:Object ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:DigitalDocument hrio:PhysicalDocument ) ] ;
    skos:prefLabel "Document"@en .

hrio:ExposureBasedHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Exposure-based Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Exposure-based Health Condition is a category used to represent health conditions that arise from contact with or presence of external agents or environments. In the model, it is shown as a subtype of externally-caused health conditions, distinguished from injury by its basis in exposure rather than direct traumatic events."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:ExternallyCausedHealthCondition,
        hrio:NonInjuryHealthCondition ;
    skos:prefLabel "Exposure-based Health Condition"@en .

hrio:ExternallyAttributedNonBinaryGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Non-binary-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Externally-attributed Non-binary-gender Person is a person to whom a non-binary gender is attributed by a gender attributor through a gender attribution. The gender attributor is a different person from the one receiving the attribution.

The class focuses on gender as assigned by another person, and it is not defined by the person's own gender identity or gender expression, or by administrative or legal recognition."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:ExternallyAttributedNonBinaryGender ],
        hrio:NonBinaryGenderPerson ;
    skos:prefLabel "Externally-attributed Non-binary-gender Person"@en .

hrio:FeminineGenderExpression a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Feminine Gender Expression"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Feminine Gender Expression is a gender expression that is characterized as feminine. It represents a feminine form of gender expression and does not, by itself, determine a person's self-identified gender."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:FemininePresentingPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:FemaleGender,
        hrio:GenderExpression ;
    skos:prefLabel "Feminine Gender Expression"@en .

hrio:HumanCell a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Human Cell"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "The fundamental structural and functional unit of the human body. A Human Cell is modeled as a kind that provides the basis for distinguishing between diploid and haploid cell types in the ontology. It is represented as the container of chromosomes, with its structural variation expressed through the number of chromosomes it includes."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Polyploid hrio:DiploidCell hrio:HaploidCell ) ] ;
    skos:prefLabel "Human Cell"@en .

hrio:LegallyRecognizedGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legally Recognized Gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition describes the person role associated with having a legally recognized gender.

Legally Recognized Gender Person denotes a person for whom a legal gender has been acknowledged through a legal gender recognition act. In this role, the person is characterized by one or more instances of legal gender that have been recognized and recorded via the associated recognition process and documentation."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:LegalGenderRecognition ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalGender ;
            owl:onProperty gufo:inheresIn ],
        hrio:AdministrativelyRecognizedGenderPerson,
        hrio:Person ;
    skos:altLabel "Person with Recognized Legal Gender"@en ;
    skos:prefLabel "Legally Recognized Gender Person"@en .

hrio:MasculineGenderExpression a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Masculine Gender Expression"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Masculine Gender Expression is a gender expression that is characterized as masculine. It represents a masculine form of gender expression and does not, by itself, determine a person's self-identified gender."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MasculinePresentingPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:GenderExpression,
        hrio:MaleGender ;
    skos:prefLabel "Masculine Gender Expression"@en .

hrio:NegativeDiagnosisAssessment a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Negative Diagnosis Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A conclusive diagnostic assessment whose result determines the absence of a diagnosis for the case at hand. It yields a No-Diagnosis Outcome."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:NoDiagnosisOutcome ;
            owl:onProperty gufo:manifestedIn ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:ConclusiveDiagnosticAssessment ;
    skos:prefLabel "Negative Diagnosis Assessment"@en .

hrio:NoDiagnosisOutcome a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "No-Diagnosis Outcome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A diagnostic assessment outcome indicating that the assessment concluded without establishing a diagnosis. It records the negative result of a conclusive assessment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:NegativeDiagnosisAssessment ;
            owl:onProperty [ owl:inverseOf gufo:manifestedIn ] ],
        hrio:DiagnosticAssessmentOutcome ;
    skos:prefLabel "No-Diagnosis Outcome"@en .

hrio:NonBinaryGenderExpression a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary Gender Expression"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Non-binary Gender Expression is a gender expression that is characterized as non-binary. It represents a non-binary form of gender expression and does not, by itself, determine a person's self-identified gender."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:NonBinaryPresentingPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:GenderExpression,
        hrio:NonBinaryGender ;
    skos:prefLabel "Non-binary Gender Expression"@en .

hrio:NonInjuryHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-injury Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Non-injury Health Condition is an abstract category that serves as a top-level grouping for conditions not defined by injury events. It functions as a root point in the model from which further classifications, such as non-structural, functional, structural, or etiology-based categories, are derived. This abstraction clarifies the distinction between conditions arising without injury and those grouped under Injury, ensuring that subsequent classifications remain consistent across the different axes represented in the diagrams."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Class ;
            owl:unionOf ( gufo:IntrinsicMode gufo:ExtrinsicMode ) ],
        gufo:Aspect ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExposureBasedHealthCondition hrio:InherentHealthCondition ) ] ;
    skos:prefLabel "Non-injury Health Condition"@en .

hrio:PathologicalHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Pathological Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Pathological Health Condition is represented as a condition that qualifies as pathological in nature. It forms one side of the complete and disjoint partition of health conditions, capturing disorders or diseases that are clinically recognized as pathological. This class serves as the basis for further specialization into categories such as disease or non-traumatic health condition."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthCondition ;
    skos:prefLabel "Pathological Health Condition"@en .

hrio:PhenotypicAmbiguousSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Ambiguous-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Includes individuals whose anatomical traits do not clearly align with either male-typical or female-typical categories. This classification acknowledges the existence of anatomical diversity and variations outside binary expectations."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:PhenotypicAmbiguousSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:IndeterminateSexPerson,
        hrio:PhenotypicSexAssessedPerson ;
    skos:prefLabel "Phenotypic Ambiguous-sex Person"@en .

hrio:PositiveDiagnosisAssessment a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Positive Diagnosis Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A conclusive diagnostic assessment whose result determines a diagnosis for the case at hand. It yields a Diagnosis."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:Diagnosis ;
            owl:onProperty gufo:manifestedIn ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:ConclusiveDiagnosticAssessment ;
    skos:prefLabel "Positive Diagnosis Assessment"@en .

hrio:SelfIdentifiedFemaleGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Female-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose female gender classification is based on self-identification, emphasizing the person as the source of the gender designation.

A Self-identified Female-gender Person is a person whose self-identified gender is female. Such a person is characterized by exactly one instance of Self-identified Female Gender, reflecting the self-identified designation of female gender associated with the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SelfIdentifiedFemaleGender ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:FemaleGenderPerson,
        hrio:SelfAwarePerson ;
    skos:prefLabel "Self-identified Female-gender Person"@en .

hrio:SelfIdentifiedMaleGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Male-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose male gender classification is based on self-identification, emphasizing the person as the source of the gender designation.

A Self-identified Male-gender Person is a person whose self-identified gender is male. Such a person is characterized by exactly one instance of Self-identified Male Gender, reflecting the self-identified designation of male gender associated with the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SelfIdentifiedMaleGender ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:MaleGenderPerson,
        hrio:SelfAwarePerson ;
    skos:prefLabel "Self-identified Male-gender Person"@en .

hrio:SelfIdentifiedNonBinaryGender a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Non-binary Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Self-identified Non-binary Gender is a non-binary gender held by a self-aware person through self-identification. It characterizes the person as non-binary from the person's own perspective and may coexist with non-binary gender attributions made by external parties or through administrative or legal assignment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SelfIdentifiedNonBinaryGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:NonBinaryGender,
        hrio:SelfIdentifiedGender ;
    skos:prefLabel "Self-identified Non-binary Gender"@en .

hrio:SexAtBirthAssignment a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex at Birth Assignment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Captures the formal process through which a newborn's sex is assigned and recorded. This mediation process connects the assigner with the person being assigned, documenting the outcome in official records."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthAssigner ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthAssignedPerson ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:BirthNotification ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:onProperty gufo:mediates ;
            owl:someValuesFrom hrio:BirthRelatedLegislationRule ],
        gufo:Relator ;
    skos:prefLabel "Sex at Birth Assignment"@en .

hrio:SexAtBirthDeterminateSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Determinate-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment """Sex-at-birth Determinate-sex Person is a Sex-at-birth-assigned Person whose recorded sex-at-birth classification is determinate, namely Sex-at-birth Male Sex or Sex-at-birth Female Sex. It excludes individuals whose sex at birth is recorded as Sex-at-birth Indeterminate Sex.

This role is defined by the recorded classification in the birth record and should be interpreted as a statement about formal assignment at birth."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SexAtBirthAssignedPerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SexAtBirthMaleSexPerson hrio:SexAtBirthFemaleSexPerson ) ] ;
    skos:prefLabel "Sex-at-birth Determinate-sex Person"@en .

hrio:SexAtBirthFemaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Female Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment """Female Sex at Birth is a sex-at-birth classification that is recorded as female during birth registration. It represents an officially documented category used in administrative and legal records.

This classification concerns what is formally recorded at birth, rather than making a claim about a person's later gender classification or gender expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthFemaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:FemaleSex,
        hrio:PhenotypicFemaleSex,
        hrio:SexAtBirth ;
    skos:prefLabel "Sex-at-birth Female Sex"@en .

hrio:SexAtBirthIndeterminateSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Indeterminate Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment """Indeterminate Sex at Birth is a Sex at Birth classification that is formally recorded as indeterminate at the time of birth. It covers cases where the birth record does not assign a male or female sex-at-birth category.

This classification reflects the outcome of formal documentation at birth and does not, by itself, determine later gender classification or gender expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthIndeterminateSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:IndeterminateSex,
        hrio:PhenotypicAmbiguousSex,
        hrio:SexAtBirth ;
    skos:prefLabel "Sex-at-birth Indeterminate Sex"@en .

hrio:SexAtBirthMaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Male Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment """Male Sex at Birth is a sex-at-birth classification that is recorded as male during birth registration. It represents an officially documented category used in administrative and legal records.

This classification concerns what is formally recorded at birth, rather than making a claim about a person's later gender classification or gender expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthMaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:MaleSex,
        hrio:PhenotypicMaleSex,
        hrio:SexAtBirth ;
    skos:prefLabel "Sex-at-birth Male Sex"@en .

hrio:SexualDimorphicCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sexual Dimorphic Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    rdfs:comment "An umbrella category for traits that show differences between sexes. These characteristics are used to classify biological sex by examining their type and distribution in an individual. Examples include body hair patterns, skeletal structure, and other anatomical features."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MaleTypicalDimorphicCharacteristic hrio:FemaleTypicalDimorphicCharacteristic hrio:IndeterminateDimorphicCharacteristic ) ] ;
    skos:prefLabel "Sexual Dimorphic Characteristic"@en .

hrio:SocialAgent a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Social Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A Social Agent is an Agent that can participate in social interactions in which socially meaningful values are attributed to persons and other agents. It provides a general notion for agents that can act in social contexts where such attributions are relevant.

Social Agent includes individual agents and organizations, covering persons and artificial agents as individual agents as well as organizational entities. It supports a uniform treatment of these participants in social contexts where socially meaningful values are attributed."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex,
        hrio:Agent ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:IndividualAgent hrio:Organization ) ] ;
    skos:prefLabel "Social Agent"@en .

hrio:Transgender a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Transgender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """Transgender is a gender modality that characterizes a person as transgender in a given modality context.

It captures non-alignment between the person's sex at birth assignment and the person's gender outcome as established in that context, including contexts grounded in self-identification and external attribution."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:TransgenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:GenderModality ;
    skos:prefLabel "Transgender"@en .

hrio:VisualSexCharacteristic a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Visual Sex Characteristic"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "An umbrella category for anatomical features used to assess phenotypic sex. These characteristics serve as the basis for classifying individuals and include observable traits that vary in typicality across sexes."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:FemaleTypicalVisualSexCharacteristic hrio:IndeterminateVisualSexCharacteristic hrio:MaleTypicalVisualSexCharacteristic ) ] ;
    skos:prefLabel "Visual Sex Characteristic"@en .

hrio:femaleGenderInheresInFemaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_1,
        hrio:woman .

hrio:maleGenderInheresInMaleGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:man,
        hrio:person_1 .

hrio:nonBinaryGenderInheresInNonBinaryGenderPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:nonBinaryPerson,
        hrio:person_1 .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Gender> a skos:Collection ;
    rdfs:label "Gender"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "erv" ;
    skos:prefLabel "Gender"@en .

hrio:personIsComponentOfVisualSexCharacteristic rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:person_2 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:sexAtBirthInheresInSexAtBirthAssignedPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:phenotypicSexInheresInPhenotypicSexAssessedPerson .

hrio:sexualDimorphicCharacteristicIsComponentOfPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:BirthBiologicalProvenance a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Birth Biological Provenance"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Birth Biological Provenance is a relator that reifies a Person�s biological origin by mediating the Person to the biological and gestational participants relevant to that origin. In this model, it links the Person to exactly one Genetic Mother, exactly one Genetic Father, and exactly one Gestational Carrier, and it is in 1�1 correspondence with the Person it describes.

The same Genetic Mother, Genetic Father, or Gestational Carrier may be related to multiple Persons via distinct Birth Biological Provenance instances. This construct concerns biological/gestational provenance and is distinct from legal or social parentage."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:GeneticMother ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:GeneticFather ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:GestationalCarrier ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:mediates ],
        gufo:Relator ;
    skos:altLabel "Biological Parentage and Gestation Provenance"@en,
        "Birth Biological Parentage Provenance"@en ;
    skos:prefLabel "Birth Biological Provenance"@en .

hrio:CellularEntity a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Cellular Entity"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Cellular Entity is represented as a general category that encompasses entities defined by a cellular structure. In the model it subsumes both living and dead cellular entities through a complete and disjoint partition, ensuring that all possible cellular states are covered. The class provides the foundation for including not only organisms but also embryos, fetuses, and cells as part of the ontology."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:FunctionalComplex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:DeadCellularEntity hrio:LivingCellularEntity ) ] ;
    skos:prefLabel "Cellular Entity"@en .

hrio:ConclusiveDiagnosticAssessment a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Conclusive Diagnostic Assessment"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment "A Diagnostic Assessment event that reaches a definitive result. It determines the diagnostic outcome without remaining uncertainty, distinguishing it from Inconclusive Diagnostic Assessment and providing the basis for the corresponding outcome type."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:DiagnosticAssessment ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NegativeDiagnosisAssessment hrio:PositiveDiagnosisAssessment ) ] ;
    skos:prefLabel "Conclusive Diagnostic Assessment"@en .

hrio:DiagnosticRelation a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnostic Relation"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment """A relator that mediates the participation of a diagnosing agent and a diagnosed entity in a diagnostic process. It is characterized by a diagnostic method that specifies how the relation is conducted.

When the process is finished, the relation can be in a concluded state, and such a concluded diagnostic relation is manifested by diagnostic assessment events that determine the assessment result type."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty gufo:mediates ;
            owl:someValuesFrom hrio:DiagnosingAgent ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:DiagnosedEntity ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:onClass hrio:DiagnosticMethod ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        gufo:Relator ;
    skos:prefLabel "Diagnostic Relation"@en .

hrio:ExternallyAttributedCisgenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Cisgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Externally-attributed Cisgender Person is a person classified as cisgender through external attribution. It captures cases where an externally attributed female or male gender classification is treated as aligned with the corresponding female or male sex-at-birth classification."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CisgenderPerson,
        hrio:ExternallyGenderAttributedPerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyAttributedCisgenderMalePerson hrio:ExternallyAttributedCisgenderFemalePerson ) ] ;
    skos:prefLabel "Externally-attributed Cisgender Person"@en .

hrio:ExternallyAttributedFemaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Female Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Externally-attributed Female Gender is a female gender designation attributed to a person by an external party. It captures female gender attributions made by someone other than the person, without assuming that the attribution matches the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyAttributedFemaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:ExternallyAttributedGender,
        hrio:FemaleGender ;
    skos:prefLabel "Externally-attributed Female Gender"@en .

hrio:ExternallyAttributedFemaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Female-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Externally-attributed Female-gender Person is a person to whom a female gender is attributed by a gender attributor through a gender attribution. The gender attributor is a different person from the one receiving the attribution.

The class focuses on gender as assigned by another person, and it is not defined by the person's own gender identity or gender expression, or by administrative or legal recognition."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:ExternallyAttributedFemaleGender ],
        hrio:FemaleGenderPerson ;
    skos:prefLabel "Externally-attributed Female-gender Person"@en .

hrio:ExternallyAttributedMaleGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Male Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Externally-attributed Male Gender is a male gender designation attributed to a person by an external party. It captures male gender attributions made by someone other than the person, without assuming that the attribution matches the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyAttributedMaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:ExternallyAttributedGender,
        hrio:MaleGender ;
    skos:prefLabel "Externally-attributed Male Gender"@en .

hrio:ExternallyAttributedMaleGenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Male-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """An Externally-attributed Male-gender Person is a person to whom a male gender is attributed by a gender attributor through a gender attribution. The gender attributor is a different person from the one receiving the attribution.

The class focuses on gender as assigned by another person, and it is not defined by the person's own gender identity or gender expression, or by administrative or legal recognition."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:ExternallyAttributedMaleGender ],
        hrio:MaleGenderPerson ;
    skos:prefLabel "Externally-attributed Male-gender Person"@en .

hrio:ExternallyAttributedNonBinaryGender a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Non-binary Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Externally-attributed Non-binary Gender is a non-binary gender designation attributed to a person by an external party. It captures non-binary gender attributions made by someone other than the person, without assuming that the attribution matches the person's self-identified gender or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyAttributedNonBinaryGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:ExternallyAttributedGender,
        hrio:NonBinaryGender ;
    skos:prefLabel "Externally-attributed Non-binary Gender"@en .

hrio:Female a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Female denotes the general outcome category for classifying a person as female without committing to whether the classification is based on sex or gender. It captures a consolidated female classification that can be used when the basis of the female determination is not stated or is intentionally left unspecified.

It provides a common female classification that can be specified as a sex-based female classification or a gender-based female classification, depending on the intended basis of determination."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Woman ;
            owl:onProperty gufo:inheresIn ],
        hrio:SexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:FemaleGender hrio:FemaleSex ) ] ;
    skos:prefLabel "Female"@en .

hrio:GenderAttribution a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gender Attribution"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """A gender attribution is an attribution relation that connects one gender attributor to one externally gender-attributed person. It represents a specific instance of externally attributing gender to a person, with the attributor as the source participant and the person as the target participant.

Each gender attribution has exactly one attributor and is directed to exactly one person, while a person can be the target of one or more gender attributions and a gender attributor can participate in one or more gender attributions. In each gender attribution, the attributor and the attributed person are not the same individual."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:GenderAttributor ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyGenderAttributedPerson ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyAttributedGender ;
            owl:onProperty gufo:mediates ],
        gufo:Relator ;
    skos:prefLabel "Gender Attribution"@en .

hrio:InherentHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Inherent Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Inherent Health Condition is a category used to represent health conditions that arise independently of external causal factors. In the model, it is placed as a subtype of known-origin health conditions, contrasted with externally-caused cases, and reflects conditions understood as intrinsic to the individual."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:IntrinsicMode,
        hrio:KnownOriginHealthCondition,
        hrio:NonInjuryHealthCondition ;
    skos:prefLabel "Inherent Health Condition"@en .

hrio:KaryotypicSex a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypic Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Refers to the classification of a person's sex based on their chromosomal composition, specifically the configuration of sex chromosomes (allosomes). It provides a genetic basis for categorizing individuals as male, female, or variants, supporting a biological understanding of sex that is typically stable across a person's life. In the model, it specializes Sex and may be further specified (e.g., karyotypic female sex, karyotypic male sex)."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:Person ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        gufo:IntrinsicMode,
        hrio:Sex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:KaryotypicMaleSex hrio:KaryotypicFemaleSex ) ] ;
    skos:prefLabel "Karyotypic Sex"@en .

hrio:LegalGenderRecognition a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Gender Recognition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition outlines the recognition act that establishes the connection between a person and a legal gender.

Legal Gender Recognition denotes a formal recognition act carried out by an authorized legal recognizer that acknowledges a specific legal gender for a person. It is the recognizing situation that links the recognizer, the person in the role of having a recognized legal gender, and the legal gender that is acknowledged, and it is formalized through an official recognition document."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegallyRecognizedGenderPerson ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalGenderRecognizer ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalGenderRecognitionDocument ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:LegalGender ;
            owl:onProperty gufo:mediates ],
        hrio:AdministrativeGenderRecognition ;
    skos:prefLabel "Legal Gender Recognition"@en .

hrio:Male a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Male denotes the general outcome category for classifying a person as male without committing to whether the classification is based on sex or gender. It captures a consolidated male classification that can be used when the basis of the male determination is not stated or is intentionally left unspecified.

It provides a common male classification that can be specified as a sex-based male classification or a gender-based male classification, depending on the intended basis of determination."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Man ;
            owl:onProperty gufo:inheresIn ],
        hrio:SexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MaleSex hrio:MaleGender ) ] ;
    skos:prefLabel "Male"@en .

hrio:Man a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Man"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Man is a person classified in the male category. It serves as a general category that covers persons classified by sex as male and persons classified by gender as male.

Sex-based male classification includes variants based on sex at birth, phenotypic sex, and karyotypic sex. Gender-based male classification includes variants based on self-identification, external attribution, legal recognition, administrative recognition, and masculine presentation. This category can be used when one or both kinds of information are available, without requiring their agreement."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Male ],
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MaleGenderPerson hrio:MaleSexPerson ) ] ;
    skos:prefLabel "Man"@en .

hrio:MultipleBirth a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Multiple Birth"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Scope: definition of Multiple Birth, its component structure, and temporal bounds.

Multiple Birth is a Birth event that comprises two or more Single Birth component events (Multiple Birth Components), each corresponding to the delivery of one offspring within the overall multiple-birth event. Each Multiple Birth has two or more components (2..*), and each Multiple Birth Component belongs to exactly one Multiple Birth (1).

Multiple Birth.start and Multiple Birth.end are derived temporal bounds (e.g., start = earliest component start; end = latest component end)."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Birth ;
    skos:altLabel "Multiple-Infant Birth Event"@en,
        "Multiple-infant Birth"@en ;
    skos:prefLabel "Multiple Birth"@en .

hrio:MultipleBirthComponent a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Multiple Birth Component"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Scope: definition of Multiple Birth Component, its relation to Multiple Birth, and ordering.

Multiple Birth Component is a Single Birth event that represents the delivery of one offspring as part of a Multiple Birth. Each Multiple Birth has two or more components (2..*), and each component belongs to exactly one Multiple Birth (1).

birth position (int, derived, multiplicity 1) records the ordinal delivery position of the component within its Multiple Birth (e.g., 1 = first delivered, 2 = second, ...), derived from the ordering of components (or from recorded clinical sequence)."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SingleBirth ;
            owl:onProperty gufo:isEventProperPartOf ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:SingleBirth ;
    skos:altLabel "Individual Birth in a Multiple Birth"@en ;
    skos:prefLabel "Multiple Birth Component"@en .

hrio:NonBinaryPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Non-binary Person is a person classified outside the male/female binary. It serves as a general category that covers persons classified by sex as indeterminate and persons classified by gender as non-binary.

Sex-based indeterminate classification includes variants based on sex at birth and phenotypic ambiguity. Gender-based non-binary classification includes variants based on self-identification, external attribution, legal recognition, administrative recognition, and non-binary presentation. This category can be used when one or both kinds of information are available."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:NonBinarySexGender ],
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NonBinaryGenderPerson hrio:IndeterminateSexPerson ) ] ;
    skos:prefLabel "Non-binary Person"@en .

hrio:NonBinarySexGender a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary Sex-Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Non-binary Sex-Gender denotes the general outcome category for classifying a person outside the male/female binary without committing to whether the classification is based on sex or gender. It captures a consolidated non-binary classification that can be used when the basis of the non-binary determination is not stated or is intentionally left unspecified.

It provides a common non-binary classification that can be specified as an indeterminate sex classification or a non-binary gender classification, depending on the intended basis of determination."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:NonBinaryPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:SexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NonBinaryGender hrio:IndeterminateSex ) ] ;
    skos:prefLabel "Non-binary Sex-Gender"@en .

hrio:NonStructuralHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-structural Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "Non-structural Health Condition is an abstract, derived category under Established Health Condition used on the aspect axis to classify conditions not identified by structural manifestation. It stands as the complement of Structural Health Condition within a complete, disjoint generalization and is further specialized by Psychological Health Condition and Functional Health Condition in a complete, overlapping set. This classification is organizational only and does not determine origin, etiology, dependence, or trauma status, which are handled on other axes."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PsychologicalHealthCondition hrio:FunctionalHealthCondition ) ] ;
    skos:prefLabel "Non-structural Health Condition"@en .

hrio:Organization a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Organization"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment "A structured group of people with a common purpose, such as a business, government agency, nonprofit, or other formal entity. Organizations can have defined roles, responsibilities, and authority to make decisions, deliver services, and interact with individuals or other organizations in systematic ways."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SocialAgent ;
    skos:prefLabel "Organization"@en .

hrio:PersonWithRegularSexChromosome a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Person with Regular Sex Chromosome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Person with Regular Sex Chromosome is represented as an individual whose sex chromosomes conform to the most frequent configurations in the population. In the model this class specializes Person and is disjoint and complete with its variant counterpart, capturing the regular chromosomal patterns used to define standard karyotypical categories. Its role is to provide the structural basis for distinguishing the commonly occurring XX and XY arrangements (reflected in Regular Karyotypical Female Person and Regular Karyotypical Male Person) from other possibilities."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:RegularKaryotypicalMalePerson hrio:RegularKaryotypicalFemalePerson ) ] ;
    skos:prefLabel "Person with Regular Sex Chromosome"@en .

hrio:PhenotypicAmbiguousSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Ambiguous Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Phenotypic Ambiguous Sex denotes the classification of a person's phenotypic sex as ambiguous when observable sex characteristics do not clearly align with male-typical or female-typical patterns in an assessment context. It provides an explicit representation of ambiguity at the level of phenotypic observation, distinct from chromosome-based classification and from administrative recording at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PhenotypicAmbiguousSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:IndeterminateSex,
        hrio:PhenotypicSex ;
    skos:prefLabel "Phenotypic Ambiguous Sex"@en .

hrio:PhenotypicFemaleSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Female-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Describes an individual assessed as having predominantly female-typical anatomical features. The classification reflects traits typically associated with female development."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:PhenotypicFemaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:FemaleSexPerson,
        hrio:PhenotypicSexAssessedPerson ;
    skos:prefLabel "Phenotypic Female-sex Person"@en .

hrio:PhenotypicMaleSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Male-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Refers to an individual assessed as having predominantly male-typical anatomical features. This classification is based on observed traits aligned with typical male development."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:PhenotypicMaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:MaleSexPerson,
        hrio:PhenotypicSexAssessedPerson ;
    skos:prefLabel "Phenotypic Male-sex Person"@en .

hrio:RegularKaryotypicalFemalePerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Regular Karyotypical Female Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Refers to individuals with the standard female chromosomal configuration, typically XX. This category aligns with the most common understanding of female karyotypical sex in biology."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:KaryotypicFemaleSexPerson,
        hrio:PersonWithRegularSexChromosome ;
    skos:prefLabel "Regular Karyotypical Female Person"@en .

hrio:RegularKaryotypicalMalePerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Regular Karyotypical Male Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Represents individuals with a typical male chromosomal configuration, usually XY. It reflects the standard genetic basis used to define male karyotypical sex in medical and genetic contexts."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:KaryotypicMaleSexPerson,
        hrio:PersonWithRegularSexChromosome ;
    skos:prefLabel "Regular Karyotypical Male Person"@en .

hrio:SelfIdentifiedCisgenderPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Cisgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Self-identified Cisgender Person is a self-aware person whose self-identified gender is aligned with the person's sex at birth. In this model, it is specialized into cisgender female and cisgender male cases by combining self-identified female or male gender with female or male sex at birth, and it is mutually exclusive with Self-identified Transgender Person."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:CisgenderPerson,
        hrio:SelfAwarePerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedCisgenderMalePerson hrio:SelfIdentifiedCisgenderFemalePerson ) ] ;
    skos:prefLabel "Self-identified Cisgender Person"@en .

hrio:SelfIdentifiedFemaleGender a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Female Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Self-identified Female Gender is a female gender held by a self-aware person through self-identification. It characterizes the person as female from the person's own perspective and may coexist with female gender attributions made by external parties or through administrative or legal assignment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:FemaleGender,
        hrio:SelfIdentifiedGender ;
    skos:prefLabel "Self-identified Female Gender"@en .

hrio:SelfIdentifiedMaleGender a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Male Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Self-identified Male Gender is a male gender held by a self-aware person through self-identification. It characterizes the person as male from the person's own perspective and may coexist with male gender attributions made by external parties or through administrative or legal assignment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:MaleGender,
        hrio:SelfIdentifiedGender ;
    skos:prefLabel "Self-identified Male Gender"@en .

hrio:SexAtBirth a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex at Birth"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Represents the formal classification of a person's sex that is recorded at the time of birth. This category acknowledges that sex at birth is not simply observed but is officially documented, often forming the basis for legal and administrative records throughout life."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SexAtBirthAssignedPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:PhenotypicSex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SexAtBirthFemaleSex hrio:SexAtBirthIndeterminateSex hrio:SexAtBirthMaleSex ) ] ;
    skos:prefLabel "Sex at Birth"@en .

hrio:TransgenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Transgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Transgender Person is a person classified as transgender in at least one gender modality context, including self-identification, external attribution, or both. This classification does not exclude concurrent cisgender classification in other gender modality contexts, supporting representation of differing attributions that may coexist for the same person."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Transgender ],
        hrio:Person,
        hrio:SexAtBirthAssignedPerson,
        hrio:SexAtBirthDeterminateSexPerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedTransgenderPerson hrio:ExternallyAttributedTransgenderPerson ) ] ;
    skos:prefLabel "Transgender Person"@en .

hrio:VariantKaryotypicalFemalePerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Variant Karyotypical Female Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Describes individuals with variations from the standard XX female configuration while still aligning with a female classification. Such variations may include atypical chromosomal arrangements that result in female phenotypes or identities."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:KaryotypicFemaleSexPerson,
        hrio:PersonWithVariantSexChromosome ;
    skos:prefLabel "Variant Karyotypical Female Person"@en .

hrio:VariantKaryotypicalMalePerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Variant Karyotypical Male Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "Includes individuals whose chromosomal patterns are considered male but differ from the standard XY configuration. For example, XXY or other variations that still lead to a male classification but with genetic differences."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:KaryotypicMaleSexPerson,
        hrio:PersonWithVariantSexChromosome ;
    skos:prefLabel "Variant Karyotypical Male Person"@en .

hrio:Woman a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Woman"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Woman is a person classified in the female category. It serves as a general category that covers persons classified by sex as female and persons classified by gender as female.

Sex-based female classification includes variants based on sex at birth, phenotypic sex, and karyotypic sex. Gender-based female classification includes variants based on self-identification, external attribution, legal recognition, administrative recognition, and feminine presentation. This category can be used when one or both kinds of information are available, without requiring their agreement."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Female ],
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:FemaleGenderPerson hrio:FemaleSexPerson ) ] ;
    skos:prefLabel "Woman"@en .

hrio:phenotypicSexInheresInPhenotypicSexAssessedPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:sexInheresInPerson .

hrio:Birth a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Birth"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Birth is an event in which one or more Persons come into existence (i.e., are created by the birth occurrence). It is specialized into Single Birth and Multiple Birth while preserving the same modeling patterns for participants and location. Each Birth occurs at exactly one Birth Place and involves exactly one Gestational Carrier, while a Birth Place or Gestational Carrier may be related to one or more Births.

A Multiple Birth aggregates at least two Multiple Birth Components. Each Multiple Birth Component belongs to exactly one Multiple Birth and is modeled as a kind of Single Birth, recording a required birth position and supporting start/end timestamps for the component occurrence."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:wasCreatedIn ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:GestationalCarrier ;
            owl:onProperty [ owl:inverseOf gufo:participatedIn ] ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:BirthPlace ;
            owl:onProperty gufo:inheresIn ],
        gufo:Event ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MultipleBirth hrio:SingleBirth ) ] ;
    skos:altLabel "Birth Event"@en,
        "Birth Occurrence"@en,
        "Birth of a Human"@en,
        "Birth of a Person"@en,
        "Human Birth"@en ;
    skos:prefLabel "Birth"@en .

hrio:Date a gufo:AbstractIndividualType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Date"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A calendar date composed of year, month, and day in the proleptic Gregorian calendar. The year is an integer that may be negative or positive. The month is a Month value. The day is an integer constrained by the month and the leap-year rule. No time-of-day or time-zone semantics are included.

Day ranges follow the usual calendar limits: April, June, September, and November have 30 days; February has 28 days, or 29 only in a leap year; the other months have 31 days. A year is a leap year iff either year mod 400 equals 0, or year mod 4 equals 0 and year mod 100 does not equal 0."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:QualityValue ;
    skos:prefLabel "Date"@en .

hrio:DiagnosedEntity a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosed Entity"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment """A substantial that plays the diagnosed role within a Diagnostic Relation. It is the thing about which a diagnosis is formed and is connected to the relation that mediates the diagnostic process.

A diagnosed entity may be characterized by conditions and by condition indicators, and it can be instantiated by varied bearers such as an organism, a biological part, a cellular entity, a specimen, or a group."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:DiagnosticRelation ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ConditionIndicator ;
            owl:onProperty gufo:inheresIn ],
        hrio:Substantial ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:DiagnosedCellularEntity hrio:DiagnosedSpecimen hrio:DiagnosedGroup hrio:DiagnosedBiologicalPart ) ] ;
    skos:prefLabel "Diagnosed Entity"@en .

hrio:DiagnosingAgent a gufo:RoleMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosing Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment """An agent that bears the diagnosing role in a diagnostic process. It participates by being mediated by a Diagnostic Relation and may be a person or an artificial agent, as indicated by the specialized types.

A diagnosing agent can be characterized by diagnosis suspicions it holds, and may also serve as an outcome issuer that issues a Diagnostic Assessment Outcome."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:DiagnosticRelation ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:DiagnosisSuspicion ],
        gufo:FunctionalComplex,
        hrio:Agent ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:DiagnosingPerson hrio:DiagnosingArtificialAgent ) ] ;
    skos:prefLabel "Diagnosing Agent"@en .

hrio:ExternallyCausedHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-caused Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Externally-caused Health Condition is a category used to represent health conditions that depend on external factors for their occurrence. In the model, it appears as a subtype of known-origin health conditions, contrasted with inherent ones, and includes cases where exposure or injury is the determining cause."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:ExtrinsicMode,
        hrio:KnownOriginHealthCondition ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Injury hrio:ExposureBasedHealthCondition ) ] ;
    skos:prefLabel "Externally-caused Health Condition"@en .

hrio:ExternallyGenderAttributedPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally Gender-attributed Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "An externally gender-attributed person is a person who is the target of one or more gender attributions made by an individual agent acting as a gender attributor. Such a person is characterized by one or more externally-attributed genders, which represent the externally held gender characterization(s) applicable to that person. This class captures cases where a person's gender is held or assigned from an external perspective rather than asserted as the person's own self-identification or gender expression."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:GenderAttribution ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:ExternallyAttributedGender ;
            owl:onProperty gufo:inheresIn ],
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyAttributedTransgenderPerson hrio:ExternallyAttributedCisgenderPerson ) ] ;
    skos:prefLabel "Externally Gender-attributed Person"@en .

hrio:GenderModality a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gender Modality"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment """Gender Modality characterizes how sex and gender information jointly determine a modality for a person.

It captures modality categories such as cisgender and transgender, grounding the modality in both sex and gender information while keeping the modality distinct from the underlying sex outcomes and gender outcomes it depends on."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:inheresIn ],
        hrio:Gender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Cisgender hrio:Transgender ) ] ;
    skos:prefLabel "Gender Modality"@en .

hrio:IndeterminateSexPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Indeterminate-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment "Describes individuals whose combination of sexual dimorphic characteristics does not clearly align with either male-typical or female-typical classifications. This category acknowledges biological variation that does not fit conventional binary classifications."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:IndeterminateSex ],
        hrio:NonBinaryPerson,
        hrio:Person ;
    skos:altLabel "Biological Indeterminate"@en,
        "Biological Indeterminate Person"@en ;
    skos:prefLabel "Indeterminate-sex Person"@en .

hrio:IndividualAgent a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Individual Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment "A single bearer of agency that can act as one countable unit. It is a subtype of Agent and excludes collective entities such as organizations. Individual Agent is specialized by Person and Artificial Agent, which partition the space of individual agents. It serves as the general type from which individual participants in recognition or other agentive relations are taken."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:SocialAgent ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ArtificialAgent hrio:Person ) ] ;
    skos:prefLabel "Individual Agent"@en .

hrio:KaryotypicFemaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypic Female Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Karyotypic Female Sex denotes the classification of a person's sex as female based on chromosomal composition, specifically the configuration of sex chromosomes used in karyotypic determination. It captures a chromosome-based basis for the female category, supporting sex classification that is grounded in karyotype rather than in phenotypic assessment or administrative recording at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:KaryotypicFemaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:FemaleSex,
        hrio:KaryotypicSex ;
    skos:prefLabel "Karyotypic Female Sex"@en .

hrio:KaryotypicMaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypic Male Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Karyotypic Male Sex denotes the classification of a person's sex as male based on chromosomal composition, specifically the configuration of sex chromosomes used in karyotypic determination. It captures a chromosome-based basis for the male category, supporting sex classification that is grounded in karyotype rather than in phenotypic assessment or administrative recording at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:KaryotypicMaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:KaryotypicSex,
        hrio:MaleSex ;
    skos:prefLabel "Karyotypic Male Sex"@en .

hrio:LegalGender a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Legal Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition clarifies what counts as legal gender and how it is grounded in formal recognition.

Legal Gender denotes a gender classification that is recognized through an official legal recognition act and is treated as the legally valid gender for a person within formal records. It is the gender used when a person is in the role of having a recognized legal gender, and it is the gender outcome that a legal recognizer acknowledges through the recognition process and its associated documentation. In the model, Legal Gender is a specialization of Administrative Gender."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:LegallyRecognizedGenderPerson ],
        [ a owl:Restriction ;
            owl:onClass hrio:LegalGenderRecognition ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:AdministrativeGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:LegalMaleGender hrio:LegalNonBinaryGender hrio:LegalFemaleGender ) ] ;
    skos:prefLabel "Legal Gender"@en .

hrio:NonTraumaticHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-traumatic Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Non-traumatic Health Condition is a category used to characterize health conditions that arise without a direct causal link to trauma. In the model, it groups together conditions that may have idiopathic or known origins, including congenital or acquired forms, thereby distinguishing them from conditions that are explicitly the result of injury or traumatic events."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition ;
    skos:prefLabel "Non-traumatic Health Condition"@en .

hrio:PersonWithVariantSexChromosome a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Person with Variant Sex Chromosome"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment "A Person with Variant Sex Chromosome is represented as an individual whose chromosomal composition departs from the most common XX or XY configurations. In the model this class complements the regular category, ensuring that cases of chromosomal variation are consistently represented. It specializes Person and accounts for less frequent patterns, maintaining completeness and disjointness with the regular classification to capture chromosomal diversity in a systematic way (reflected in Variant Karyotypical Female Person and Variant Karyotypical Male Person)."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:VariantKaryotypicalFemalePerson hrio:KaryotypicalIndeterminatePerson hrio:VariantKaryotypicalMalePerson ) ] ;
    skos:prefLabel "Person with Variant Sex Chromosome"@en .

hrio:SelfIdentifiedNonBinaryGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Non-binary-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment """This class focuses on persons whose non-binary gender classification is based on self-identification, emphasizing the person as the source of the gender designation.

A Self-identified Non-binary-gender Person is a person whose self-identified gender is non-binary. Such a person is characterized by exactly one instance of Self-identified Non-binary Gender, reflecting the self-identified designation of non-binary gender associated with the person."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:maxQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SelfIdentifiedNonBinaryGender ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ],
        hrio:NonBinaryGenderPerson,
        hrio:SelfAwarePerson ;
    skos:prefLabel "Self-identified Non-binary-gender Person"@en .

hrio:Substantial a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Substantial"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/UFO> ;
    rdfs:comment "Particular is the most general notion of an individual entity. It refers to any single concrete entity that can bear properties and participate in relations, covering endurant entities such as Substantial and its non-agentive and agentive forms (Object and Agent)."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:Object,
        hrio:Endurant ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Agent hrio:Object ) ] ;
    skos:prefLabel "Substantial"@en .

<https://w3id.org/health-ri/ontology#package/UFO> a skos:Collection ;
    rdfs:label "UFO"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "UFO"@en .

hrio:selfIdentifiedGenderInheresInSelfAwarePerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subPropertyOf hrio:person_1 .

hrio:sexInheresInPerson rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:AdministrativeGender a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Administrative Gender is a gender designation that is externally attributed and recorded for administrative purposes by an organization or system. It captures the gender outcome used in administrative records and other administrative contexts, rather than a person's self-identified gender. An administrative gender characterizes a person as the outcome of an administrative gender recognition. It is a specialization of externally-attributed gender and may be further specialized (e.g., legal gender) when grounded in formal legal authority."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativelyRecognizedGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        [ a owl:Restriction ;
            owl:onClass hrio:AdministrativeGenderRecognition ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:ExternallyAttributedGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:AdministrativeNonBinaryGender hrio:AdministrativeFemaleGender hrio:AdministrativeMaleGender ) ] ;
    skos:altLabel "Administrative Gender Marker"@en,
        "Civil Registry Gender"@en,
        "Civil Registry Gender Marker"@en,
        "Official Gender Marker"@en,
        "Population Register Gender"@en,
        "Population Register Gender Marker"@en,
        "Recorded Gender"@en,
        "Registered Gender"@en,
        "Registry Gender Marker"@en ;
    skos:prefLabel "Administrative Gender"@en .

hrio:AdministrativeGenderRecognition a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Administrative Gender Recognition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """Administrative Gender Recognition is the formal recognition act through which an organization assigns or recognizes a person's administrative gender. It links the recognizing organization, the recognition agent, the person whose gender is being recognized, and the resulting administrative gender designation.

Each administrative gender recognition is carried out by a recognition agent and is recorded in an administrative gender recognition document created by that agent."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativeGenderRecognizingOrganization ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativelyRecognizedGenderPerson ;
            owl:onProperty gufo:mediates ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognitionAgent ],
        [ a owl:Restriction ;
            owl:onProperty gufo:mediates ;
            owl:someValuesFrom hrio:AdministrativeGenderRecognitionDocument ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:AdministrativeGender ;
            owl:onProperty gufo:mediates ],
        hrio:GenderAttribution ;
    skos:prefLabel "Administrative Gender Recognition"@en .

hrio:Agent a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Agent"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/UFO> ;
    rdfs:comment "Agent is a substantial capable of acting and participating in goal-directed interactions. It subsumes organizations and individual agents, the latter including persons and artificial agents. Agents may bear agentive roles such as Diagnosing Agent when engaged in domain-specific activities."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:Object,
        hrio:Substantial ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SocialAgent hrio:Animal ) ] ;
    skos:prefLabel "Agent"@en .

hrio:CisgenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Cisgender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> ;
    rdfs:comment "Cisgender Person is a person assigned a cisgender modality, indicating alignment between a gender classification for the person and the person's sex-at-birth classification. The alignment may be established using self-identified gender or using externally-attributed gender, depending on the specific cisgender classification that applies to the person."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Cisgender ],
        hrio:Person,
        hrio:SexAtBirthAssignedPerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyAttributedCisgenderPerson hrio:SelfIdentifiedCisgenderPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:FemaleCisgenderPerson hrio:MaleCisgenderPerson ) ] ;
    skos:prefLabel "Cisgender Person"@en .

hrio:Diagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment """A diagnostic assessment outcome that asserts the presence of a condition for a diagnosed entity. It results from a positive diagnosis assessment and serves as the recorded outcome of the diagnostic process for the case at hand.

As an outcome, it stands in contrast to a No-Diagnosis Outcome and provides the basis for classifying specific kinds of diagnoses used in practice."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PositiveDiagnosisAssessment ;
            owl:onProperty [ owl:inverseOf gufo:manifestedIn ] ],
        hrio:DiagnosticAssessmentOutcome ;
    skos:altLabel "Diagnosis Outcome"@en,
        "Diagnosis Result"@en ;
    skos:prefLabel "Diagnosis"@en .

hrio:FemaleSexPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment "Refers to a person whose sexual dimorphic characteristics align more strongly with those typically classified as female. The classification is based on the predominance of female-typical features in the overall assessment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:FemaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality "3"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:FemaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ],
        hrio:Person,
        hrio:Woman ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PhenotypicFemaleSexPerson hrio:KaryotypicFemaleSexPerson ) ] ;
    skos:altLabel "Biological Female"@en,
        "Biological Female Person"@en ;
    skos:prefLabel "Female-sex Person"@en .

hrio:HealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Health Condition is represented as a specialization of Condition associated with an animal entity. In the model it serves as the general category from which more specific health-related distinctions are derived. It provides the structural basis for differentiating pathological, non-pathological, risk-based, and established conditions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Condition ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:RiskBasedHealthCondition hrio:EstablishedHealthCondition ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:PathologicalHealthCondition hrio:NonPathologicalHealthCondition ) ] ;
    skos:altLabel "health condition"@en ;
    skos:prefLabel "Health Condition"@en .

hrio:IndeterminateSex a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Indeterminate Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment """Indeterminate Sex denotes the general category for classifying a person's sex as indeterminate when available biological traits do not support a clear male or female classification. It supports representing biological variation that does not fit binary sex categories, while allowing more specific determinations based on assessment, chromosomal composition, or the sex recorded at birth.

This classification concerns biological sex categorization and is distinct from Gender and Gender Expression, which address social characterization and expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:IndeterminateSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:NonBinarySexGender,
        hrio:Sex ;
    skos:prefLabel "Indeterminate Sex"@en .

hrio:KnownOriginHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Known-Origin Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "A Known-Origin Health Condition is a category used to represent health conditions for which a specific cause can be identified. In the model, it is contrasted with idiopathic cases, emphasizing the distinction between conditions explained by their etiology and those without a clear causal account."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:EstablishedHealthCondition ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:CongenitalHealthCondition hrio:AcquiredHealthCondition ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyCausedHealthCondition hrio:InherentHealthCondition ) ] ;
    skos:prefLabel "Known-Origin Health Condition"@en .

hrio:LivingPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Living Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Living Person denotes the life-status phase of a person whose life is ongoing. Together with Dead Person it forms a complete and disjoint partition of persons by living status. Within this phase, the life-stage subclasses Child, Adolescent, and Adult form a complete and disjoint specialization, and the self-awareness subclasses Self-aware Person and Non-self-aware Person form a complete and disjoint specialization."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NonSelfAwarePerson hrio:SelfAwarePerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:Adult hrio:Child hrio:Adolescent ) ] ;
    skos:prefLabel "Living Person"@en .

hrio:MaleSexPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment "Describes a person whose overall set of sexual dimorphic characteristics aligns more strongly with those typically classified as male. This classification relies on counting or weighting traits that are conventionally considered male-typical."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ],
        [ a owl:Restriction ;
            owl:maxQualifiedCardinality "3"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ],
        hrio:Man,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PhenotypicMaleSexPerson hrio:KaryotypicMaleSexPerson ) ] ;
    skos:altLabel "Biological Male"@en,
        "Biological Male Person"@en ;
    skos:prefLabel "Male-sex Person"@en .

hrio:NonBinaryGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Non-binary-gender Person is a person who is characterized by at least one instance of Non-binary Gender. It captures membership in the non-binary gender outcome regardless of whether that characterization comes from self-identification or gender expression, or from external attribution, including administrative or legal assignment. It does not imply any particular sex at birth and does not exclude additional gender characterizations."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:NonBinaryGender ],
        hrio:NonBinaryPerson,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyAttributedNonBinaryGenderPerson hrio:SelfIdentifiedNonBinaryGenderPerson hrio:NonBinaryPresentingPerson ) ] ;
    skos:prefLabel "Non-binary-gender Person"@en .

hrio:PhenotypicFemaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Female Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Phenotypic Female Sex denotes the classification of a person's phenotypic sex as female based on observable anatomical and morphological features, as established through clinical or visual assessment. It provides a female classification tied to phenotypic observation, supporting a clear distinction from chromosome-based classification and from administrative recording at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PhenotypicFemaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:FemaleSex,
        hrio:PhenotypicSex ;
    skos:prefLabel "Phenotypic Female Sex"@en .

hrio:PhenotypicMaleSex a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Male Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Phenotypic Male Sex denotes the classification of a person's phenotypic sex as male based on observable anatomical and morphological features, as established through clinical or visual assessment. It provides a male classification tied to phenotypic observation, supporting a clear distinction from chromosome-based classification and from administrative recording at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PhenotypicMaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:MaleSex,
        hrio:PhenotypicSex ;
    skos:prefLabel "Phenotypic Male Sex"@en .

hrio:PhenotypicSex a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Represents the observable anatomical and morphological features that inform sex classification, such as genitalia, secondary sexual traits, and body structure. It is determined through clinical or visual assessment and can vary across individuals."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:PhenotypicSexAssessedPerson ;
            owl:onProperty gufo:inheresIn ],
        gufo:ExtrinsicMode,
        hrio:Sex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PhenotypicMaleSex hrio:PhenotypicFemaleSex hrio:PhenotypicAmbiguousSex ) ] ;
    skos:altLabel "Received Phenotypic Sex"@en ;
    skos:prefLabel "Phenotypic Sex"@en .

hrio:PhenotypicSexAssessedPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Phenotypic-sex-assessed Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Describes an individual whose phenotypic sex has been evaluated and categorized, typically by a healthcare professional. This classification recognizes that phenotypic sex is not simply \"given\" but results from an assessment process."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:someValuesFrom hrio:PhenotypicSexAssessment ],
        [ a owl:Restriction ;
            owl:onClass hrio:PhenotypicSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:PhenotypicMaleSexPerson hrio:PhenotypicAmbiguousSexPerson hrio:PhenotypicFemaleSexPerson ) ] ;
    skos:prefLabel "Phenotypic-sex-assessed Person"@en .

hrio:SexAtBirthFemaleSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Female-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Denotes individuals officially assigned as female in their birth record, based on clinical observation of anatomical features immediately after birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirthFemaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:PhenotypicFemaleSexPerson,
        hrio:SexAtBirthAssignedPerson,
        hrio:SexAtBirthDeterminateSexPerson ;
    skos:prefLabel "Sex-at-birth Female-sex Person"@en .

hrio:SexAtBirthMaleSexPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth Male-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Denotes individuals officially assigned as male in their birth record, typically based on observed anatomical features at the time of delivery."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirthMaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:PhenotypicMaleSexPerson,
        hrio:SexAtBirthAssignedPerson,
        hrio:SexAtBirthDeterminateSexPerson ;
    skos:prefLabel "Sex-at-birth Male-sex Person"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> a skos:Collection ;
    rdfs:label "Sex Outcome"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Sex Outcome"@en .

hrio:FemaleGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Female-gender Person is a person who is characterized by at least one instance of Female Gender. It captures membership in the female gender outcome regardless of whether that characterization comes from self-identification or gender expression, or from external attribution, including administrative or legal assignment. It does not imply any particular sex at birth and does not exclude additional gender characterizations."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:FemaleGender ],
        hrio:Person,
        hrio:Woman ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedFemaleGenderPerson hrio:ExternallyAttributedFemaleGenderPerson hrio:FemininePresentingPerson ) ] ;
    skos:prefLabel "Female-gender Person"@en .

hrio:KaryotypicMaleSexPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypic Male-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment """A person whose karyotypical sex is male, determined by the sex chromosome complement. This class classifies persons by karyotype only and does not depend on phenotypic traits or on any sex assigned or assessed at birth or later.

Karyotypic Male-sex Person subsumes both Regular Karyotypical Male Person and Variant Karyotypical Male Person, which are categorized as male in the model. It is exclusive with Karyotypic Female-sex Person within the karyotypical-sex classification of persons."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:KaryotypicMaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:MaleSexPerson,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:VariantKaryotypicalMalePerson hrio:RegularKaryotypicalMalePerson ) ] ;
    skos:prefLabel "Karyotypic Male-sex Person"@en .

hrio:MaleGenderPerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male-gender Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Male-gender Person is a person who is characterized by at least one instance of Male Gender. It captures membership in the male gender outcome regardless of whether that characterization comes from self-identification or gender expression, or from external attribution, including administrative or legal assignment. It does not imply any particular sex at birth and does not exclude additional gender characterizations."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:MaleGender ],
        hrio:Man,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedMaleGenderPerson hrio:ExternallyAttributedMaleGenderPerson hrio:MasculinePresentingPerson ) ] ;
    skos:prefLabel "Male-gender Person"@en .

hrio:SelfIdentifiedGender a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-identified Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition clarifies the self-ascribed gender that characterizes a self-aware person.

Self-identified Gender denotes the gender with which a self-aware person identifies, as expressed through self-identification rather than third-party attribution. It captures the person's own identification as the basis for the gender characterization used in self-identification contexts."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SelfAwarePerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Gender,
        hrio:SelfDesignatedGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedFemaleGender hrio:SelfIdentifiedMaleGender hrio:SelfIdentifiedNonBinaryGender ) ] ;
    skos:altLabel "Gender Identity"@en,
        "Self-assigned Gender"@en,
        "Self-attributed Gender"@en ;
    skos:prefLabel "Self-identified Gender"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> a skos:Collection ;
    rdfs:label "Sex"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "erv" ;
    skos:prefLabel "Sex"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> a skos:Collection ;
    rdfs:label "Sex-Gender Outcome"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "erv" ;
    skos:prefLabel "Sex-Gender Outcome"@en .

hrio:person_1 rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> .

hrio:ExternallyAttributedGender a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Externally-attributed Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment """This definition covers what an externally-attributed gender represents and how it functions as a gender characterization of a person.

An externally-attributed gender is a gender characterization that applies to a person as a result of someone else's attribution. It represents the gender outcome(s) assigned to, recorded for, or otherwise held about a person from an external viewpoint, and it is used to distinguish external attribution from gender expressed through self-identification or gender expression. In the model, administrative gender and legal gender are more specific forms of externally-attributed gender."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:ExternallyGenderAttributedPerson ],
        [ a owl:Restriction ;
            owl:onClass hrio:GenderAttribution ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        gufo:ExtrinsicMode,
        hrio:Gender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:ExternallyAttributedFemaleGender hrio:ExternallyAttributedNonBinaryGender hrio:ExternallyAttributedMaleGender ) ] ;
    skos:prefLabel "Externally-attributed Gender"@en .

hrio:FemaleGender a gufo:PhaseMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Female Gender is a gender that characterizes a person as female. It supports representing a person's female gender across different contexts, including self-identification, gender expression, external attribution, and administrative or legal assignment, without implying any particular sex at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:FemaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Female,
        hrio:Gender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedFemaleGender hrio:ExternallyAttributedFemaleGender hrio:FeminineGenderExpression ) ] ;
    skos:prefLabel "Female Gender"@en .

hrio:FemaleSex a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Female Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment """Female Sex denotes the general category for classifying a person's sex as female based on biological traits related to reproductive anatomy, chromosomes, and other physical characteristics. It provides a common female classification that can be further specified by more concrete bases of determination, including karyotypic sex, phenotypic sex, and the sex recorded at birth.

This classification concerns biological sex categorization and is distinct from Gender and Gender Expression, which address social characterization and expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:FemaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Female,
        hrio:Sex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:KaryotypicFemaleSex hrio:PhenotypicFemaleSex ) ] ;
    skos:prefLabel "Female Sex"@en .

hrio:GenderExpression a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gender Expression"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> ;
    rdfs:comment "Gender Expression is a self-designated gender characteristic that represents how a person expresses gender. It is distinct from self-identified gender and characterizes a person independently of any particular self-identification."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:SelfAwarePerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Gender,
        hrio:SelfDesignatedGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MasculineGenderExpression hrio:FeminineGenderExpression hrio:NonBinaryGenderExpression ) ] ;
    skos:prefLabel "Gender Expression"@en .

hrio:KaryotypicFemaleSexPerson a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Karyotypic Female-sex Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology> ;
    rdfs:comment """A person whose karyotypical sex is female, determined by the sex chromosome complement. This class classifies persons by karyotype only and does not depend on phenotypic traits or on any sex assigned or assessed at birth or later.

Karyotypic Female-sex Person subsumes both Regular Karyotypical Female Person and Variant Karyotypical Female Person, which are categorized as female in the model. It is exclusive with Karyotypic Male-sex Person within the karyotypical-sex classification of persons."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:KaryotypicFemaleSex ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:FemaleSexPerson,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:VariantKaryotypicalFemalePerson hrio:RegularKaryotypicalFemalePerson ) ] ;
    skos:prefLabel "Karyotypic Female-sex Person"@en .

hrio:MaleGender a gufo:PhaseMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Male Gender is a gender that characterizes a person as male. It supports representing a person's male gender across different contexts, including self-identification, gender expression, external attribution, and administrative or legal assignment, without implying any particular sex at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MaleGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Gender,
        hrio:Male ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedMaleGender hrio:ExternallyAttributedMaleGender hrio:MasculineGenderExpression ) ] ;
    skos:prefLabel "Male Gender"@en .

hrio:MaleSex a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Male Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexOutcome> ;
    rdfs:comment """Male Sex denotes the general category for classifying a person's sex as male based on biological traits related to reproductive anatomy, chromosomes, and other physical characteristics. It provides a common male classification that can be further specified by more concrete bases of determination, including karyotypic sex, phenotypic sex, and the sex recorded at birth.

This classification concerns biological sex categorization and is distinct from Gender and Gender Expression, which address social characterization and expression."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MaleSexPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Male,
        hrio:Sex ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:KaryotypicMaleSex hrio:PhenotypicMaleSex ) ] ;
    skos:altLabel "Biological Male Sex"@en ;
    skos:prefLabel "Male Sex"@en .

hrio:NonBinaryGender a gufo:PhaseMixin,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Non-binary Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> ;
    rdfs:comment "Non-binary Gender is a gender that characterizes a person as non-binary, meaning not exclusively male or female. It supports representing a person's non-binary gender across different contexts, including self-identification, gender expression, external attribution, and administrative or legal assignment, without implying any particular sex at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:NonBinaryGenderPerson ;
            owl:onProperty gufo:inheresIn ],
        hrio:Gender,
        hrio:NonBinarySexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NonBinaryGenderExpression hrio:ExternallyAttributedNonBinaryGender hrio:SelfIdentifiedNonBinaryGender ) ] ;
    skos:prefLabel "Non-binary Gender"@en .

hrio:SelfAwarePerson a gufo:Phase,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Self-aware Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment "Represents a phase of a Person characterized by the capacity for self-awareness. A Self-aware Person can recognize themselves as a distinct individual, reflect on their own thoughts and experiences, and potentially form concepts such as personal identity and gender identity. This phase typically develops over time and enables participation in complex social roles."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:GenderExpression ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:LivingPerson,
        hrio:Person ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedFemaleGenderPerson hrio:SelfIdentifiedNonBinaryGenderPerson hrio:SelfIdentifiedMaleGenderPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedTransgenderPerson hrio:SelfIdentifiedCisgenderPerson ) ] ;
    skos:prefLabel "Self-aware Person"@en .

hrio:SexGender a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/SexGenderOutcome> ;
    rdfs:comment """Sex-Gender denotes the general outcome category for classifying a person using sex and/or gender information when the representation does not require distinguishing sex classification from gender characterization. It captures the consolidated sex-gender classification at the highest level of abstraction used for these outcomes.

It provides a common space for male, female, and non-binary classifications at this consolidated level, while allowing a more specific basis of determination to be made explicit when needed."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Class ;
            owl:unionOf ( gufo:IntrinsicMode gufo:ExtrinsicMode ) ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:inheresIn ],
        gufo:Aspect ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:Female hrio:NonBinarySexGender hrio:Male ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:Sex hrio:Gender ) ] ;
    skos:prefLabel "Sex-Gender"@en .

hrio:SingleBirth a gufo:EventType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Single Birth"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/PersonBirth> ;
    rdfs:comment """Scope: definition of Single Birth, temporal attributes, and offspring linkage.

Single Birth is a Birth event that results in the delivery of exactly one offspring (Person). It has start and end attributes typed as OffsetDateTime (multiplicity 1 each).

A Single Birth is associated with exactly one Person via offspring (1), and each Person is linked to exactly one Single Birth (1). Single Birth is partitioned into:
- Singleton Birth (standalone single birth), and
- Multiple Birth Component (single birth occurring as part of a Multiple Birth)."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:Person ;
            owl:onProperty [ owl:inverseOf gufo:wasCreatedIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "2"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:MultipleBirthComponent ;
            owl:onProperty [ owl:inverseOf gufo:isEventProperPartOf ] ],
        hrio:Birth ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SingletonBirth hrio:MultipleBirthComponent ) ] ;
    skos:altLabel "Birth Event of One Infant"@en,
        "Per-infant Birth Event"@en,
        "Single-outcome Birth"@en ;
    skos:prefLabel "Single Birth"@en .

hrio:EstablishedHealthCondition a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Established Health Condition"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> ;
    rdfs:comment "An Established Health Condition is represented as a condition that is already present and identifiable, as opposed to a risk or predisposition. In the model it stands in contrast to risk-based health conditions, forming part of a complete and disjoint partition of health condition nature types. It provides the structural basis for organizing conditions that have been diagnosed or are otherwise clinically recognized, supporting their classification according to structural, functional, psychological, or etiological aspects."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:HealthCondition ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:NonTraumaticHealthCondition hrio:TraumaticHealthCondition ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:StructuralHealthCondition hrio:NonStructuralHealthCondition ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:KnownOriginHealthCondition hrio:IdiopathicHealthCondition ) ] ;
    skos:prefLabel "Established Health Condition"@en .

hrio:SexAtBirthAssignedPerson a gufo:Role,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex-at-birth-assigned Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> ;
    rdfs:comment "Describes an individual who has received a recorded sex classification during the birth registration process. This role reflects the outcome of a formal assignment that categorizes the person as male, female, or indeterminate at birth."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirthAssignment ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:onClass hrio:SexAtBirth ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:Person,
        hrio:PhenotypicSexAssessedPerson ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:SexAtBirthMaleSexPerson hrio:SexAtBirthFemaleSexPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:TransgenderPerson hrio:CisgenderPerson hrio:SexAtBirthIndeterminateSexPerson ) ] ;
    skos:prefLabel "Sex-at-birth-assigned Person"@en .

<https://w3id.org/health-ri/ontology#package/PersonBirth> a skos:Collection ;
    rdfs:label "Person Birth"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "irv" ;
    skos:prefLabel "Person Birth"@en .

hrio:HealthcareDiagnosis a gufo:SubKind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Healthcare Diagnosis"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Diagnosis> ;
    rdfs:comment """A diagnosis formulated within healthcare practice about an organism-level case. It concerns a patient or animal as a whole, rather than cellular-level objects.

In the model it is organized by focus (human or veterinary), by source of evidence (for example clinical, laboratory, radiological, epidemiological, or administrative coding origins), and by use (care-oriented, surveillance, or research)."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf hrio:Diagnosis ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:EpidemiologicalDiagnosis hrio:ClinicalDiagnosis hrio:RadiologicalDiagnosis hrio:AdministrativeCodingDiagnosis hrio:LaboratoryDiagnosis ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:VeterinaryDiagnosis hrio:HumanHealthcareDiagnosis ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:ResearchDiagnosis hrio:CareOrientedDiagnosis hrio:SurveillanceDiagnosis ) ] ;
    skos:prefLabel "Healthcare Diagnosis"@en .

hrio:OffsetDateTime a gufo:AbstractIndividualType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "OffsetDateTime"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """A civil date-time with explicit UTC offset and nanosecond precision. It consists of a Date plus hour, minute, second, optional nanosecond, and utcOffsetMinutes. Hour is 0..23. Minute is 0..59. Second is 0..59; leap seconds (value 60) are out of scope and inputs with second equal to 60 must be rejected. Nanosecond, when present, is an integer in 0..999999999. The value 24:00:00 is not permitted.

The UTC offset is expressed as an integer number of minutes east of UTC in the closed range -840..+840. Any whole-minute offset is allowed, including zones that use 30 or 45 minute increments. The offset qualifies the local date-time but does not imply time-zone rules such as daylight-saving transitions."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:QualityValue ;
    skos:altLabel "Date-time with Offset"@en,
        "DateTime with UTC Offset"@en,
        "Offset Date-time"@en ;
    skos:prefLabel "OffsetDateTime"@en .

hrio:Sex a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Sex"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Sex> ;
    rdfs:comment "Denotes the overall category for classifying a person's biological traits related to reproductive anatomy, chromosomes, and other physical characteristics. It includes different dimensions such as karyotypical sex (chromosomal composition), phenotypic sex (observable anatomical features), and sex at birth (the classification assigned during birth registration). This category emphasizes that sex, while grounded in biology, can involve observation, interpretation, and formal assignment."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:inheresIn ],
        hrio:SexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:MaleSex hrio:FemaleSex hrio:IndeterminateSex ) ] ;
    skos:altLabel "Biological Sex"@en ;
    skos:prefLabel "Sex"@en .

<https://w3id.org/health-ri/ontology#package/Person> a skos:Collection ;
    rdfs:label "Person"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Person"@en .

hrio:Month a gufo:AbstractIndividualType,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Month"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment "An enumeration with exactly twelve values: January, February, March, April, May, June, July, August, September, October, November, and December. These values are used to designate the month component of a calendar date."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf gufo:QualityValue ;
    owl:equivalentClass [ a owl:Class ;
            owl:oneOf ( hrio:January hrio:February hrio:March hrio:April hrio:May hrio:June hrio:July hrio:August hrio:September hrio:October hrio:November hrio:December ) ] ;
    skos:prefLabel "Month"@en .

hrio:Gender a gufo:Category,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Gender"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/SexAndGender/Gender> ;
    rdfs:comment "Gender is the broad category of gender characterizations that can be attributed to a person, either by the person themselves or by others. It covers gender designated by the person, including self-identified gender and gender expression, as well as externally attributed gender, including administrative and legal forms used for recognition by organizations or legal institutions."@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:Person ;
            owl:onProperty gufo:inheresIn ],
        hrio:SexGender ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:FemaleGender hrio:MaleGender hrio:NonBinaryGender ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:SelfIdentifiedGender hrio:ExternallyAttributedGender hrio:GenderExpression ) ] ;
    skos:altLabel "Social Gender"@en ;
    skos:prefLabel "Gender"@en .

<https://w3id.org/health-ri/ontology#package/General> a skos:Collection ;
    rdfs:label "General"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "General"@en .

hrio:Address a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Address"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/General> ;
    rdfs:comment """Address is the quality that specifies a conventional locator for an Addressable Place. It captures the information used to refer to a place for identification and locating purposes in human and system communication.

Each Address is associated with one or more Addressable Places, and each Addressable Place is associated with one or more Addresses, supporting both shared and multiple address assignments where this is required for unambiguous reference."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty gufo:inheresIn ;
            owl:someValuesFrom hrio:AddressablePlace ],
        gufo:Quality ;
    skos:prefLabel "Address"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderModality> a skos:Collection ;
    rdfs:label "Gender Modality"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Gender Modality"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderOutcome> a skos:Collection ;
    rdfs:label "Gender Outcome"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Gender Outcome"@en .

<https://w3id.org/health-ri/ontology#package/Biology> a skos:Collection ;
    rdfs:label "Biology"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Biology"@en .

<https://w3id.org/health-ri/ontology#package/Biology/HealthCondition> a skos:Collection ;
    rdfs:label "Health Condition"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Health Condition"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Sex/SexAxis> a skos:Collection ;
    rdfs:label "Sex Axis"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Sex Axis"@en .

<https://w3id.org/health-ri/ontology#package/SexAndGender/Gender/GenderContext> a skos:Collection ;
    rdfs:label "Gender Context"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Gender Context"@en .

<https://w3id.org/health-ri/ontology#package/Diagnosis> a skos:Collection ;
    rdfs:label "Diagnosis"@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    vs:term_status "int" ;
    skos:prefLabel "Diagnosis"@en .

hrio:Person a gufo:Kind,
        owl:Class,
        owl:NamedIndividual ;
    rdfs:label "Person"@en ;
    dct:isPartOf <https://w3id.org/health-ri/ontology#package/Person> ;
    rdfs:comment """Person is a kind that denotes a single human individual as an agentive biological individual. Within the Agent hierarchy it is treated as an Individual Agent and a biological animal. The class provides the enduring identity of the human across time and contexts and abstracts from specific classifications or statuses.

A Person may bear intrinsic modes such as Sex and Gender, which can be assessed, assigned, or institutionally recognized and give rise to roles including Phenotypic-sex-assessed Person, Sex-at-birth-assigned Person, Legally Recognized Gender Person, and Administratively Recognized Gender Person. A Person may also instantiate phases such as Living Person and Dead Person, and may play social or professional roles such as Offspring, Diagnosing Person, or Healthcare Professional."""@en ;
    rdfs:isDefinedBy <https://w3id.org/health-ri/ontology> ;
    rdfs:subClassOf [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Sex ],
        [ a owl:Restriction ;
            owl:minQualifiedCardinality "1"^^xsd:nonNegativeInteger ;
            owl:onClass hrio:KaryotypicSex ;
            owl:onProperty gufo:inheresIn ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:Gender ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:inheresIn ] ;
            owl:someValuesFrom hrio:SexGender ],
        [ a owl:Restriction ;
            owl:onClass hrio:SingleBirth ;
            owl:onProperty gufo:wasCreatedIn ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        [ a owl:Restriction ;
            owl:onProperty [ owl:inverseOf gufo:wasCreatedIn ] ;
            owl:someValuesFrom hrio:Birth ],
        [ a owl:Restriction ;
            owl:onClass hrio:BirthBiologicalProvenance ;
            owl:onProperty [ owl:inverseOf gufo:mediates ] ;
            owl:qualifiedCardinality "1"^^xsd:nonNegativeInteger ],
        hrio:Animal,
        hrio:IndividualAgent ;
    owl:equivalentClass [ a owl:Class ;
            owl:unionOf ( hrio:LegallyRecognizedGenderPerson hrio:LegallyUnassignedGenderPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:MaleGenderPerson hrio:FemaleGenderPerson hrio:NonBinaryGenderPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:PersonWithRegularSexChromosome hrio:PersonWithVariantSexChromosome ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:KaryotypicMaleSexPerson hrio:KaryotypicFemaleSexPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:NonBinaryPerson hrio:Man hrio:Woman ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:LivingPerson hrio:DeadPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:SexAtBirthAssignedPerson hrio:SexAtBirthUnassignedPerson ) ],
        [ a owl:Class ;
            owl:unionOf ( hrio:IndeterminateSexPerson hrio:MaleSexPerson hrio:FemaleSexPerson ) ] ;
    skos:altLabel "Human"@en,
        "Human Being"@en ;
    skos:prefLabel "Person"@en .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:KaryotypicFemaleSex hrio:PhenotypicFemaleSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:KaryotypicMaleSex hrio:PhenotypicMaleSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:FemaleTypicalVisualSexCharacteristic hrio:IndeterminateVisualSexCharacteristic hrio:MaleTypicalVisualSexCharacteristic ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:KaryotypicMaleSex hrio:KaryotypicFemaleSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:PhenotypicMaleSex hrio:PhenotypicFemaleSex hrio:PhenotypicAmbiguousSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:GenderExpression hrio:SelfIdentifiedGender ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:Cisgender hrio:Transgender ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:AllosomeX hrio:AllosomeY ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:RegularKaryotypicalMalePerson hrio:RegularKaryotypicalFemalePerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:SelfIdentifiedGender hrio:ExternallyAttributedGender hrio:GenderExpression ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:PersonWithRegularSexChromosome hrio:PersonWithVariantSexChromosome ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:VariantKaryotypicalFemalePerson hrio:KaryotypicalIndeterminatePerson hrio:VariantKaryotypicalMalePerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:KaryotypicMaleSexPerson hrio:KaryotypicFemaleSexPerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:VariantKaryotypicalFemalePerson hrio:RegularKaryotypicalFemalePerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:VariantKaryotypicalMalePerson hrio:RegularKaryotypicalMalePerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:Person hrio:NonHumanAnimal ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:NonTraumaticHealthCondition hrio:TraumaticHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:CongenitalHealthCondition hrio:AcquiredHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:StructuralHealthCondition hrio:NonStructuralHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:RiskBasedHealthCondition hrio:EstablishedHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:ExternallyCausedHealthCondition hrio:InherentHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:PhenotypicSex hrio:KaryotypicSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:ExposureBasedHealthCondition hrio:InherentHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:KnownOriginHealthCondition hrio:IdiopathicHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:PathologicalHealthCondition hrio:NonPathologicalHealthCondition ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:ArtificialAgent hrio:Person ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:DigitalDocument hrio:PhysicalDocument ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:IndividualAgent hrio:Organization ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:Diagnosis hrio:NoDiagnosisOutcome ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:ConclusiveDiagnosticAssessment hrio:InconclusiveDiagnosticAssessment ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:NegativeDiagnosisAssessment hrio:PositiveDiagnosisAssessment ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:PostmortemDiagnosis hrio:AntemortemDiagnosis ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:EpidemiologicalDiagnosis hrio:ClinicalDiagnosis hrio:RadiologicalDiagnosis hrio:AdministrativeCodingDiagnosis hrio:LaboratoryDiagnosis ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:VeterinaryDiagnosis hrio:HumanHealthcareDiagnosis ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:Agent hrio:Object ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:MultipleBirth hrio:SingleBirth ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:SingletonBirth hrio:MultipleBirthComponent ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:Sex hrio:Gender ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:MaleTypicalDimorphicCharacteristic hrio:FemaleTypicalDimorphicCharacteristic hrio:IndeterminateDimorphicCharacteristic ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:IndeterminateSexPerson hrio:MaleSexPerson hrio:FemaleSexPerson ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:SexAtBirthFemaleSex hrio:SexAtBirthIndeterminateSex hrio:SexAtBirthMaleSex ) .

[] a owl:AllDisjointClasses ;
    owl:members ( hrio:MaleSex hrio:FemaleSex hrio:IndeterminateSex ) .